<ARTICLE>                     5
<LEGEND>
THIS  SCHEDULE  CONTAINS  SUMMARY  FINANCIAL   INFORMATION  EXTRACTED  FROM  THE
FINANCIAL STATEMENTS OF CRYOLIFE, INC. FOR THE YEAR ENDED DECEMBER 31, 1999, AND
IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<CIK>                         0000784199
<NAME>                        CRYOLIFE, INC.

                                        

<PERIOD-TYPE>                              12-MOS
<FISCAL-YEAR-END>                              DEC-31-1999
<PERIOD-START>                                 JAN-01-1999
<PERIOD-END>                                   DEC-31-1999

<CASH>                                          6,128,000
<SECURITIES>                                   24,403,000
<RECEIVABLES>                                  11,694,000
<ALLOWANCES>                                      528,000
<INVENTORY>                                     4,597,000
<CURRENT-ASSETS>                               67,550,000
<PP&E>                                         30,517,000
<DEPRECIATION>                                 11,843,000
<TOTAL-ASSETS>                                 94,025,000
<CURRENT-LIABILITIES>                           7,622,000
<BONDS>                                         6,644,000
<PREFERRED-MANDATORY>                                   0
<PREFERRED>                                             0
<COMMON>                                          134,000
<OTHER-SE>                                     80,092,000
<TOTAL-LIABILITY-AND-EQUITY>                   94,025,000
<SALES>                                         6,329,000
<TOTAL-REVENUES>                               66,722,000
<CGS>                                           5,754,000
<TOTAL-COSTS>                                  30,170,000
<OTHER-EXPENSES>                               30,051,000
<LOSS-PROVISION>                                  121,000
<INTEREST-EXPENSE>                                387,000
<INCOME-PRETAX>                                 6,501,000
<INCOME-TAX>                                    2,050,000
<INCOME-CONTINUING>                             4,451,000
<DISCONTINUED>                                          0
<EXTRAORDINARY>                                         0
<CHANGES>                                               0
<NET-INCOME>                                    4,451,000
<EPS-BASIC>                                         .36
<EPS-DILUTED>                                         .36