SCHEDULE 14A INFORMATION
                  Proxy Statement Pursuant to Section 14(a) of
                       the Securities Exchange Act of 1934
                                (Amendment No. )

Filed by the Registrant [X]

Filed by a Party other than the Registrant [_]

Check the appropriate box:

[_] Preliminary Proxy Statement             [ ] Confidential, for Use of the
[X] Definitive Proxy Statement                  Commission Only (as permitted by
[_] Definitive Additional Materials             Rule 14a-6(e)(2))
[_] Soliciting Material Pursuant to
    (ss.)240.14a-11(c) or (ss.)240.14a-12

                                 CRYOLIFE, INC.
                (Name of Registrant as Specified In Its Charter)

                                       N/A
                   ------------------------------------ ----
     (Name of Person(s) Filing Proxy Statement if other than the Registrant)


Payment of Filing Fee (Check the appropriate box):

[X] No fee required.

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    paid  previously.  Identify the  previous filing by  registration  statement
    number, or the Form or Schedule and the date of its filing.

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                      [Logo of CryoLife, Inc. Appears Here]
[LOGO]                     1655 ROBERTS BOULEVARD, N.W.
                             KENNESAW, GEORGIA 30144


                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS

TO THE SHAREHOLDERS OF CRYOLIFE, INC.:

      NOTICE  IS  HEREBY  GIVEN  that the  Annual  Meeting  of  Shareholders  of
CRYOLIFE, INC. will be held at the Sheraton Suites  Galleria-Atlanta,  2844 Cobb
Parkway,  SE,  Atlanta,  Georgia 30339,  on May 17, 2001 at 10:00 a.m.,  Atlanta
time, for the following purposes:

      1.   To elect seven  directors  to serve until the next Annual  Meeting of
           Shareholders  or until  their  successors  are  elected and have been
           qualified.

      2.   To transact such other business  as  may  properly  come  before  the
           meeting or any adjournments  thereof.

      The proxy statement dated April 4, 2001 is attached.

      Only record holders of CryoLife's common stock at the close of business on
March 16, 2001 will be eligible to vote at the meeting.

      Your  attendance at the annual meeting is very much desired.  However,  if
there is any chance you may not be able to attend the meeting,  please  execute,
complete,  date and return the proxy in the enclosed envelope. If you attend the
meeting, you may revoke the proxy and vote in person.

                                             By Order of the Board of Directors:

                                             /s/ Steven G. Anderson

                                             STEVEN G. ANDERSON,
                                             Chairman of the Board and President


Date: April 4, 2001

      A copy of the Annual  Report of  CryoLife,  Inc. for the fiscal year ended
December 31, 2000 containing financial statements is enclosed.






                      [Logo of CryoLife, Inc. Appears Here]
[LOGO]                    1655 ROBERTS BOULEVARD, N.W.
                             KENNESAW, GEORGIA 30144

                                 PROXY STATEMENT
                       FOR ANNUAL MEETING OF SHAREHOLDERS

      This proxy  statement is furnished  for the  solicitation  by the Board of
Directors of proxies for the Annual Meeting of Shareholders of CryoLife, Inc. to
be held on May 17, 2001, at 10:00 a.m.,  Atlanta  time,  at the Sheraton  Suites
Galleria-Atlanta,  2844 Cobb Parkway, SE, Atlanta, Georgia 30339. The sending in
of a signed  proxy will not affect a  shareholder's  right to attend the meeting
and vote in person. A signed proxy may be revoked by the sending in of a timely,
but later dated, signed proxy. Any shareholder giving a proxy may also revoke it
at any time before it is exercised by giving oral or written notice to Ronald D.
McCall,  Secretary of CryoLife, or Ms. Suzanne Gabbert,  Assistant Secretary, at
the offices of CryoLife.  Oral notice may be delivered by telephone  call to Ms.
Gabbert, at the offices of CryoLife, at (770) 419-3355.

      Holders of record of  CryoLife's  common stock at the close of business on
March  16,  2001  will be  eligible  to vote at the  meeting.  CryoLife's  stock
transfer  books will not be closed.  At the close of business on March 16, 2001,
CryoLife had outstanding a total of 18,750,704 shares of common stock, excluding
a total of 1,340,530  shares of treasury  stock held by CryoLife,  which are not
entitled to vote. Each such share will be entitled to one vote,  non-cumulative,
at the meeting.

      Other than the matters set forth  herein,  management  is not aware of any
other  matters that may come before the meeting.  If any other  business  should
properly come before the meeting,  the persons named in the enclosed  proxy will
have  discretionary  authority to vote the shares  represented  by the effective
proxies and intend to vote them in accordance with their best judgment.

      This proxy  statement and the attached proxy were first mailed to security
holders  on behalf of  CryoLife  on or about  April 4, 2001.  Properly  executed
proxies,  timely  returned,  will be  voted  and,  where  the  person  solicited
specifies  by means of a ballot a choice with  respect to any matter to be acted
upon at the meeting,  the shares will be voted as indicated by the  shareholder.
If the person  solicited  does not specify a choice with  respect to election of
directors,  the shares will be voted for  management's  nominees for election as
directors.  In addition to the  solicitation of proxies by the use of the mails,
directors  and officers of CryoLife may solicit  proxies on behalf of management
by  telephone,  telegram  and personal  interview.  Such persons will receive no
additional  compensation  for  their  solicitation   activities,   and  will  be
reimbursed  only for their actual  expenses  incurred.  The costs of  soliciting
proxies will be borne by CryoLife.

VOTING PROCEDURES AND VOTE REQUIRED

      The Secretary of CryoLife,  in  consultation  with the judges of election,
who  will be  employees  of  CryoLife's  transfer  agent,  shall  determine  the
eligibility of persons present at the Annual Meeting to vote and shall determine
whether  the  name  signed  on each  proxy  card  corresponds  to the  name of a
shareholder of CryoLife. The Secretary,  based on such consultation,  shall also
determine  whether or not a quorum of the shares of  CryoLife,  consisting  of a
majority of the votes entitled to be cast at the Annual  Meeting,  exists at the
Annual  Meeting.  Both  abstentions  from  voting and broker  non-votes  will be
counted for the purpose of  determining  the presence or absence of a quorum for
the transaction of business.

      Nominees for  election as directors  will be elected by a plurality of the
votes cast by the  holders of shares  entitled  to vote in the  election.  Since
there  are  seven  directorships  to  be  filled,  this  means  that  the  seven
individuals  receiving  the most votes will be elected.  Abstentions  and broker
non-votes will therefore not be relevant to the outcome.

      There  are no rights of  appraisal  or  similar  dissenters'  rights  with
respect to any matter to be acted upon pursuant to this proxy statement.

                                       1



RECOMMENDATION OF THE BOARD OF DIRECTORS

      The Board of Directors of CryoLife recommends a vote "FOR" the election of
each of the nominees named below for election as director.

ELECTION OF DIRECTORS

      The proxy  holders  intend to vote "FOR"  election of the  nominees  named
below, who are currently members of the Board, as directors of CryoLife,  unless
otherwise  specified in the proxy.  Directors of CryoLife  elected at the Annual
Meeting  to be held on May 17,  2001 will  hold  office  until  the next  Annual
Meeting or until their successors are elected and qualified.

      Each of the nominees has consented to serve on the Board of Directors,  if
elected.  Should any nominee for the office of director  become unable to accept
nomination  or election,  which is not  anticipated,  it is the intention of the
persons  named in the proxy,  unless  otherwise  specifically  instructed in the
proxy, to vote for the election of such other person as the Board may recommend.

      The  individuals  listed below as nominees for the Board of Directors were
directors of CryoLife during all of 2000. The name and age of each nominee,  and
the period during which such person has served as a director,  together with the
number of shares of  CryoLife's  common stock  beneficially  owned,  directly or
indirectly,  by  such  person  and  the  percentage  of  outstanding  shares  of
CryoLife's  common stock such ownership  represented at the close of business on
March 16, 2001,  according  to  information  received by CryoLife,  is set forth
below:




                                                                                

                                                                     Shares of
                                                                   CryoLife Stock
                                                                 Beneficially Owned           Percentage of
                                      Service as                         at                 Outstanding Shares
        Name of Nominee                Director        Age        March 16, 2000(1)         of CryoLife Stock
- ---------------------------------    --------------   ------    ---------------------      ---------------------
Steven G. Anderson                    Since 1984        62              1,757,167(2)              9.36%
John M. Cook (4)                      Since 1999        58                 60,750(3)                *
Ronald C. Elkins, M.D.(4)(5)          Since 1994        64                159,619(6)                *
Virginia C. Lacy(4)(5)                Since 1997        59                672,079(7)              3.56%
Ronald D. McCall, Esq.(5)             Since 1984        63                242,763(8)              1.29%
Alexander C. Schwartz, Jr.(4)         Since 1999        68                 41,250(9)                *
Bruce J. Van Dyne, M.D.(5)            Since 1999        59                 41,550(9)                *
- ---------------


* Ownership  represents  less than 1% of outstanding  shares of CryoLife  common
  stock.


(1)  Except as otherwise noted,  the nature of the beneficial  ownership for all
     shares is sole voting and investment power.
(2)  Includes  157,999  shares  held  of  record  by Ms.  Ann B.  Anderson,  Mr.
     Anderson's spouse. Also includes options to acquire 27,000 shares of common
     stock which are presently  exercisable or will become exercisable within 60
     days after the date of this proxy statement.
(3)  Includes 19,500 shares which are held by CT  Investments,  LLC of which Mr.
     Cook owns 90% of the  membership  interests.  Includes  options  to acquire
     41,250  shares of common  stock  which are  presently  exercisable  or will
     become exercisable within 60 days after the date of this proxy statement.
(4)  Member of the Audit Committee.
(5)  Member of the Compensation Advisory Committee.
(6)  Includes  options  to  acquire  125,250  shares of common  stock  which are
     presently  exercisable or will become  exercisable within 60 days after the
     date of this proxy statement.
(7)  Includes  358,450 shares held as  beneficiary of three trusts,  and 165,879
     shares  held as  beneficiary  of an IRA,  of Ms.  Lacy's  deceased  spouse.
     Includes 22,500 shares held as  administrator  of a pension plan.  Includes
     125,250 shares  subject to options which are presently  exercisable or will
     become exercisable within 60 days after the date of this proxy statement.

                                       2


(8)  Includes  16,000 shares of common stock owned of record by Ms. Marilyn B.
     McCall,  Mr. McCall's spouse.  Includes options to acquire 114,750 shares
     of  common  stock  which  are  presently   exercisable   or  will  become
     exercisable within 60 days after the date of this proxy statement.
(9)  Includes  options  to acquire  41,250  shares of common  stock  which are
     presently exercisable or will become exercisable within 60 days after the
     date of this proxy statement.

     Steven G.  Anderson,  a  founder  of  CryoLife,  has  served as  CryoLife's
President,  Chief Executive Officer and Chairman of the Board of Directors since
its  inception.  Mr.  Anderson  has  more  than 30 years  of  experience  in the
implantable  medical device industry.  Prior to founding CryoLife,  Mr. Anderson
was Senior  Executive Vice President and Vice  President,  Marketing,  from 1976
until  1983 of  Intermedics,  Inc.  (now  Guidant  Corp.),  a  manufacturer  and
distributor of pacemakers and other medical devices.  Mr. Anderson is a graduate
of the University of Minnesota.

     John M. Cook has served as a Director of CryoLife  since August  1999.  Mr.
Cook is  Chairman  and Chief  Executive  Officer  of The Profit  Recovery  Group
International,  Inc.,  an  international,  publicly  held  audit  recovery  firm
operating in 36 countries,  with 2000 revenues exceeding $297 million.  Mr. Cook
has served as Chief  Executive  Officer of The Profit  Recovery  Group since its
founding in January 1991.  Prior to The Profit  Recovery  Group,  he served in a
number  of top  financial  and  management  positions  in the  retail  industry,
including Senior Vice President and Chief Financial Officer of Caldor Stores and
Senior Vice President of Finance and Controller of Kaufmann's Department Stores,
both May Department Stores affiliates. He holds a B.S. degree in accounting from
Saint Louis University, where he serves as a member of the Board of Trustees and
holds a seat on the  Executive  Advisory  Board of the  University's  School  of
Business and Administration.

     Ronald C. Elkins,  M.D., has served as a Director of CryoLife since January
1994. Dr. Elkins is Professor and Chief,  Section of Thoracic and Cardiovascular
Surgery,  University of Oklahoma  Health Science  Center.  Dr. Elkins has been a
physician  at the Health  Science  Center  since 1971,  and has held his present
position  since 1975. Dr. Elkins is a graduate of the University of Oklahoma and
Johns Hopkins Medical School.

     Virginia C. Lacy has served as a Director of CryoLife  since  August  1997.
Ms. Lacy received her BA degree from  Northwestern  University in 1963. Ms. Lacy
is the  Administrator  of The Jeannette & John Cruikshank  Memorial  Foundation,
which  provides  housing  assistance  to those in need  throughout  the  greater
Chicago area. Since 1974, Ms. Lacy has served as  Secretary-Treasurer  and Chief
Financial  Officer of Precision  Devices  Corporation,  a distributor of medical
devices.  She was one of the  founders of the company and serves as the Chairman
of the Board of Directors. She has also served as the Chief Financial Officer of
A.I.  Industries,  a manufacturer  of  identification  cards for the health care
industry.  As an elected member of the Board of Education of District 203 of the
State of Illinois, she served on its budget committee, which was responsible for
planning and reviewing the spending of $100,000,000 in public funds each year in
a school district having 2,500 employees.  Ms. Lacy also provided  leadership in
State  Education  by serving on  committees  that  analyzed  state  funding  for
education.  She  continues to keep abreast of new financial  strategies  through
participation in American Management Association classes.

     Ronald D.  McCall,  Esq.  has served as a Director of  CryoLife  and as the
Secretary  and  Treasurer  of  CryoLife  since  January  1984.  From 1985 to the
present, Mr. McCall has been the proprietor of the law firm of Ronald D. McCall,
Attorney  at Law,  based in Tampa,  Florida.  Mr.  McCall  was  admitted  to the
practice of law in Florida in 1961.  Mr.  McCall  received his BA and JD degrees
from the University of Florida.

     Alexander  C.  Schwartz,  Jr. has served as a Director  of  CryoLife  since
September 1999. Mr. Schwartz retired from Prudential Securities in 1996 after 33
years of service.  While at  Prudential  Securities  he held various  positions,
including co-head of the Investment  Banking Division,  Managing Director of the
firm's International Division and Managing Director of the Health Care Group. As
co-head of the  Investment  Banking  Division he was in charge of due  diligence
teams reviewing and analyzing corporate  finances.  Mr. Schwartz was responsible
for the review of  financial  and  accounting  records of  corporations  and the
presentation  of the  corporations'  financial  performance  in connection  with
initial  public  offerings,  debt  offerings,  leveraged  buyouts,  mergers  and
acquisitions.  Mr.  Schwartz  is a graduate  of  Columbia  University,  where he
received a B.S.  Degree in Economics.  Mr.  Schwartz has served on the Boards of
Directors of several  public and  privately  held  companies  and is currently a
private investor.

                                       3


     Bruce J. Van Dyne,  M.D. has served as a Director of CryoLife  since August
1999.  Dr.  Van Dyne is a  board-certified  neurologist  and has been in private
practice  in  Minneapolis,  Minnesota  since  1975.  He has  served in  numerous
advisory positions, including as an Examiner in Neurology for the American Board
of  Psychiatry  and  Neurology  and as previous  Chairman of the  Department  of
Neurology for Park Nicollet  Medical Center in Minneapolis.  He is a graduate of
Northwestern  University  Medical  School and is the author of numerous  medical
publications in the field of neurology.

                    INFORMATION ABOUT THE BOARD OF DIRECTORS
                           AND COMMITTEES OF THE BOARD

     Meetings of the Board of  Directors--During  2000, there were five meetings
of the Board of Directors.

     Director Compensation--All non-employee directors of the Board of Directors
of  CryoLife  are paid  $1,500 for each Board  meeting  attended.  In  addition,
directors are reimbursed for expenses incurred in connection with their services
as a director. In December 1997, CryoLife adopted the CryoLife, Inc. Amended and
Restated  Non-Employee  Directors Stock Option Plan,  which replaced  CryoLife's
1995  Non-Employee  Directors Plan.  Pursuant to this plan,  options to purchase
7,500 shares of common  stock were granted to each of Drs.  Elkins and Van Dyne,
Messrs.  Cook,  McCall and Schwartz and Ms. Lacy immediately  following the 2000
Annual Meeting of Shareholders.  The Amended and Restated Non-Employee Directors
Stock  Option  Plan  provides  that an  annual  grant  will be  made  each  year
immediately  following CryoLife's Annual Meeting of Shareholders of an option to
purchase 7,500 shares of common stock to each individual  elected,  reelected or
continuing as a non-employee director of CryoLife.  All options granted pursuant
to this plan are granted at a purchase  price equal to the last closing price of
CryoLife's  common stock on the New York Stock  Exchange on the day  immediately
prior to the grant of the option and vest and become exercisable on the option's
grant date. No option granted  pursuant to this plan may be exercised later than
five years  following  the date of grant.  Also,  on May 26, 2000,  each of Drs.
Elkins and Van Dyne,  Messrs.  Cook, McCall and Schwartz and Ms. Lacy received a
special grant of options to purchase 15,000 shares of common stock.

     In addition to the foregoing,  Dr. Elkins received approximately $75,000 in
consulting  fees and Dr. Van Dyne  received  approximately  $4,500 in consulting
fees from CryoLife in 2000.

     Audit  Committee--CryoLife's  Audit Committee consists of four non-employee
directors:  Dr. Elkins, Mr. Cook, Mr. Schwartz and Ms. Lacy. The Audit Committee
met seven  times in 2000.  The Audit  Committee  reviews  the  general  scope of
CryoLife's  annual audit and the nature of services to be performed for CryoLife
in connection  therewith,  acting as liaison  between the Board of Directors and
the  independent  auditors.  The Audit  Committee  also  formulates  and reviews
various company policies,  including those relating to accounting  practices and
internal  control  systems of  CryoLife.  In  addition,  the Audit  Committee is
responsible   for  reviewing  and  monitoring  the   performance  by  CryoLife's
independent  auditors  and for  recommending  the  engagement  or  discharge  of
CryoLife's independent auditors.

     Compensation Advisory Committee--CryoLife's Compensation Advisory Committee
consisted of four non-employee  directors during 2000: Mr. McCall, Ms. Lacy, Dr.
Elkins and Dr. Van Dyne. The Compensation  Advisory Committee met three times in
2000. The  Compensation  Advisory  Committee is  responsible  for evaluating the
performance  of officers and setting the annual  compensation  for all officers,
including  the salary and the  compensation  package of  executive  officers.  A
portion of the  compensation  package  includes a bonus award.  The Compensation
Advisory Committee also administers  CryoLife's  benefit plans,  except that the
Compensation  Advisory   Sub-Committee  approves  grants  of  stock  options  to
executive officers under CryoLife's benefit plans.  Currently,  the Compensation
Advisory Sub-Committee consists of two non-employee directors:  Ms. Lacy and Dr.
Van Dyne. The Compensation Advisory Sub-Committee met three times in 2000.

     Nominating   Committee--CryoLife   does  not  have  a  standing  nominating
committee of the Board of Directors.

     During 2000,  no director  attended  fewer than 75% of the aggregate of the
total  number of  meetings  of the Board of  Directors  and the total  number of

                                       4


meetings held by all committees of the Board on which he or she served.  Members
of the Board of Directors are  appointed to committees at the annual  meeting of
directors immediately following the annual meeting of shareholders.

     Notwithstanding  anything to the  contrary  set forth in any of  CryoLife's
filings under the Securities Act of 1933, as amended, or the Securities Exchange
Act of  1934,  as  amended,  that  might  incorporate  other  CryoLife  filings,
including this proxy statement,  in whole or in part, the following  Reports and
Performance Graph shall not be incorporated by reference into any such filings.

                          REPORT OF THE AUDIT COMMITTEE

     The Board of Directors  maintains an Audit  Committee  comprised of four of
the Company's outside directors.  The Board of Directors and the Audit Committee
believe that the Audit Committee's current member composition satisfies the rule
of  the  New  York  Stock  Exchange   ("NYSE")  that  governs  audit   committee
composition,  including  the  requirement  that audit  committee  members all be
"independent  directors"  as that term is defined by Section  303.01 of the NYSE
Listed Company Manual.

     The Audit Committee  oversees the Company's  financial process on behalf of
the  Board of  Directors.  Management  has the  primary  responsibility  for the
financial  statements  and the  reporting  process,  including  the  systems  of
internal  controls.  In  fulfilling  its oversight  responsibilities,  the Audit
Committee  reviewed the audited  financial  statements in the Annual Report with
management,  including a discussion of the quality,  not just the acceptability,
of the accounting  principles,  the reasonableness of significant  judgments and
the clarity of disclosures in the financial statements.  The Board has adopted a
written  Audit  Committee  Charter,  a copy of which is  attached  as Appendix A
hereto.

     The  Audit  Committee  reviewed  with  the  independent  auditors,  who are
responsible  for  expressing  an  opinion  on the  conformity  of those  audited
financial  statements  with  generally  accepted  accounting  principles,  their
judgments  as to the  quality,  not just  the  acceptability,  of the  Company's
accounting  principles  and such other  matters as are  required to be discussed
with the Audit Committee under generally accepted auditing standards,  including
statement on Auditing  Standards  No. 61. In addition,  the Audit  Committee has
discussed  with  the  independent  auditors  the  auditors'   independence  from
management and the Company, including the matters in the written disclosures and
the letter from the independent auditors required by the Independence  Standards
Board, Standard No. 1.

     The Audit Committee discussed with the Company's  independent  auditors the
overall  scope and plans for their  audit.  The Audit  Committee  meets with the
independent  auditors,  with and  without  management  present,  to discuss  the
results  of  their  examination,  their  evaluation  of the  Company's  internal
controls  and the overall  quality of the  Company's  financial  reporting.  The
Company  incurred the following fees for services  performed by Arthur  Andersen
LLP in 2000:

Audit Fees

     Fees for the year  2000  audit and the  review  of Forms  10-Q in 2000 were
$81,750,  of which an  aggregate  amount  of  $21,000  had been  billed  through
December 31, 2000.

Financial Information Systems Design and Implementation Fees

     Arthur  Andersen  LLP did not render  any  services  related  to  financial
information  systems design and  implementation  for the year ended December 31,
2000.

All Other Fees

     Aggregate  fees billed for all other services  rendered by Arthur  Andersen
LLP for the year ended December 31, 2000 were $93,125.

                                       5


     The Audit  Committee  has not  considered  whether the payments made to its
independent  accountants  for non-audit  services for 2000 are  compatible  with
maintaining such auditor's independence.

     In reliance on the reviews  and  discussions  referred to above,  the Audit
Committee  members  did not  become  aware of any  misstatement  in the  audited
financial  statements  and  recommended to the Board of Directors (and the Board
has approved) that the audited financial statements be included in the Company's
Annual Report on Form 10-K for the year ended  December 31, 2000 for filing with
the Securities and Exchange  Commission.  The Audit Committee and the Board have
also approved the selection of the Company's independent auditors.

                                                Audit Committee

                                                VIRGINIA C. LACY, CHAIRMAN
                                                JOHN M. COOK
                                                RONALD C. ELKINS, M.D.
                                                ALEXANDER C. SCHWARTZ, JR.

                                       6



                REPORT OF THE COMPENSATION ADVISORY COMMITTEE ON
                             EXECUTIVE COMPENSATION

OVERVIEW

     The Compensation  Advisory Committee of the Board of Directors of CryoLife,
Inc. is composed of  non-employee  directors  and approves the  compensation  of
CryoLife's  executive  officers at least  annually.  The Committee  believes the
actions  of  executive  officers  of  CryoLife  have a  profound  impact  on the
short-term and long-term  profitability  of CryoLife.  Therefore,  the Committee
gives significant attention to the design of CryoLife's compensation package.

     CryoLife's  compensation  package consists of three parts and is relatively
simple in design.  The three primary  parts are a base salary,  a cash bonus and
stock-based incentive  compensation.  No significant perquisites are provided to
executive officers.

BASE SALARY

     The Committee  believes it is important  for  executive  officers and other
employees  of  CryoLife to receive  acceptable  salaries  so that  CryoLife  can
recruit and retain the talent it needs.  For several  years,  the  Committee has
obtained a salary  survey  report.  This survey,  which is entitled the "Radford
Salary  Survey  for U.S.  Biotech  Companies,"  contains  information  regarding
salaries paid to various biotech  executives in the United States. The Committee
reviews this salary survey  primarily for  information  regarding  salaries,  as
opposed  to bonus and stock  incentive  information.  In setting  salaries,  the
Committee takes into consideration the individual employee's performance, length
of service to CryoLife,  and the information provided by the Radford Survey. The
Committee  seeks to set  compensation  at levels which are reasonable  under the
circumstances  and near the midrange for U.S. biotech  companies.  For 2000, the
Compensation  Advisory  Committee  considered  it advisable to make  significant
increases  in  salaries  in  order  to  provide  its  executive   officers  with
compensation in the same range as that of executives employed by other companies
in the industry.  Salaries for executive  officers were raised by 15.5%,  on the
average,  as compared  to 1999.  The range of  increases  was from 5.8% to 24.8%
including a salary increase for one officer when he was promoted from Controller
to Vice President and Chief Financial Officer in April 2000. The base salary for
each executive officer is set on a subjective basis,  bearing in mind an overall
impression of that executive's  relative skills,  experience and contribution to
CryoLife. The Committee does not attempt to address the relative weight assigned
to the various  factors,  which are  evaluated on a subjective  overall basis by
each individual member of the Committee.  Salaries of all executive officers are
reviewed  annually by the  Committee.  In accordance  with this  procedure,  the
Committee consults with Mr. Anderson,  the President and Chief Executive Officer
of CryoLife,  and an appropriate range of base salary,  bonus, and stock options
is subjectively considered, based upon the range of compensation received by the
other executive officers and the requirements of the particular  positions to be
filled.  The Chief Executive Officer  negotiates with candidates for employment,
subject to acceptance and  ratification  by the Committee,  and this  negotiated
base salary is reflected in each candidate's employment agreement.

CASH BONUSES

     Cash bonuses are the next component of executive officer  compensation.  In
determining  the  amount  to be paid  as  bonuses  to  executive  officers,  the
Compensation  Advisory  Committee  considers  the  performance  of  CryoLife  in
reaching  goals  for  increased  revenues  and  pre-tax  profit  as  well as the
performance  of each executive  officer.  For 2000,  the  Compensation  Advisory
Committee  based its  decision  that  bonuses  should be awarded  to  CryoLife's
executive  officers  upon its  subjective  determination  that  CryoLife's  2000
increases in total  revenues  together  with the  achievement  of certain  goals
justified the granting thereof.  During 2000, CryoLife reached significant goals
with regard to the  SynerGraft  valve and BioGlue  products  and the sale of the
remaining assets of Ideas for Medicine, Inc. to Horizon Medical, Inc. The amount
of the bonus paid to individual executive officers was determined based upon the
Committee's  subjective  analysis  of the  performance  of  each  such  officer.
Excluding the cash bonus paid to the Chief  Executive  Officer,  2000  executive
officer bonuses ranged from $30,000 to $70,000 and were paid in 2001.

                                       7



STOCK-BASED INCENTIVES

     Stock-based  incentives have been a supplemental  component of compensation
for  CryoLife's  executive  officers,  and certain  other  employees,  since the
formation of CryoLife.  CryoLife  adopted formal incentive stock option plans in
1984,  1989,  1993 and  1998.  CryoLife  has also made  grants of  non-qualified
options  under an informal  stock option  program.  The  Sub-Committee  approves
grants of stock options to executive officers under CryoLife's option plans.

     Historically,  grants made by CryoLife have  generally  vested at a rate of
20% per year and have had a term of five and one-half years.  These options also
usually expire upon termination of employment, except in the event of disability
or  death,  in which  case the term of the  option  may  continue  for some time
thereafter.

     The  Sub-Committee  believes that CryoLife's  stock option program has been
effective  in  focusing  attention  on  shareholder  value  since the gain to be
realized by executive officers upon exercise of options will change as the stock
price changes.  The Sub-Committee also believes that the long-term nature of the
options  encourages  CryoLife's  executive  officers  to remain  with  CryoLife.
Finally,  the  Sub-Committee  has found it appropriate to grant options to newly
employed  executive  officers in order to  encourage  such  officers to identify
promptly with  CryoLife's  goal of increased  shareholder  value.  The number of
shares to be granted is established  utilizing the procedure  described above at
"--Base Salary." The Sub-Committee  subjectively determines the number of shares
to be  granted  based on its  analysis  of the  number  which  would  provide an
adequate  incentive  to the new  executive  officer  to accept a  position  with
CryoLife.

     In general,  following  initial  employment,  the  granting of  stock-based
incentives  to  executive  officers is  considered  by the  Sub-Committee  to be
justified  when  CryoLife's  revenues and earnings,  coupled with the individual
executive's  performance,  warrant supplemental  compensation in addition to the
salary and bonus paid with  respect to a given  year.  Each of these  factors is
weighed  subjectively by Sub-Committee  members in determining  whether or not a
stock-based  incentive  should be granted,  and such  incentives are not granted
routinely.  Stock-based  incentives  were granted to six  executive  officers to
purchase in the aggregate,  127,500 shares during 2000. The Committee  thinks it
unlikely  that  any   participants  in  CryoLife's  stock  plans  will,  in  the
foreseeable  future,  receive in excess of $1 million in aggregate  compensation
(the  maximum  amount for which an employer may claim a  compensation  deduction
pursuant to Section  162(m) of the Internal  Revenue Code of 1986 unless certain
performance-related compensation exemptions are met) during any fiscal year, and
has therefore  determined that CryoLife will not take any affirmative  action at
this time to meet the requirements of such exemptions.

COMPENSATION OF THE CHIEF EXECUTIVE OFFICER

     The  Committee  fixed the 2000  salary of Mr.  Steven  G.  Anderson,  Chief
Executive Officer of CryoLife, at $520,000 and awarded Mr. Anderson a cash bonus
of $300,000 for his  performance  and  significant  service to CryoLife in 2000.
This bonus  reflected an increase of $75,000 over the 1999 bonus.  This exhibits
the  philosophy  of the  Committee  as set forth at "--Base  Salary" and "--Cash
Bonuses"  above.  In 2000,  Mr.  Anderson was granted  stock options to purchase
30,000 shares of common  stock.  The  Committee  and  Sub-Committee  believe the
compensation of Mr. Anderson,  a founder of CryoLife,  reflects their subjective
opinions that Mr. Anderson has provided superlative leadership and fulfilled the
functions of an executive officer of CryoLife at the highest level.


                                       8



CONCLUSION

     The Committee and  Sub-Committee  believe that the mix of a cash salary and
bonuses  and a long-term  stock  incentive  compensation  program  represents  a
balance that has motivated and will continue to motivate  CryoLife's  management
team to produce the best results possible given overall economic  conditions and
the difficulty of predicting CryoLife's performance in the short term.

                                       COMPENSATION ADVISORY
                                            COMMITTEE:

                                       RONALD D. McCALL, CHAIRMAN
                                       VIRGINIA C. LACY
                                       RONALD C. ELKINS, M.D.
                                       BRUCE J. VAN DYNE, M.D.

                                       COMPENSATION ADVISORY
                                            SUB-COMMITTEE:

                                       VIRGINIA C. LACY
                                       BRUCE J. VAN DYNE, M.D.


                                       9



                                PERFORMANCE GRAPH

     Set forth  below is a  line-graph  presentation  comparing  the  cumulative
shareholder  return on CryoLife's  common stock,  on an indexed  basis,  against
cumulative  total returns of the Russell 2000 Index, and a "peer group" selected
by management of CryoLife.  The peer group  selected for inclusion in this proxy
statement  includes Advanced Tissue Sciences,  Inc.,  Osteotech,  Inc.,  Closure
Medical Corp. and LifeCell  Corporation.  Each of these companies has securities
traded on the Nasdaq Stock Market.  Advanced  Tissue and Osteotech were selected
because  they had been  utilized  as a basis for  comparison  with  CryoLife  in
reports by analysts for each of the two co-managers of CryoLife's initial public
offering. Management selected LifeCell to be included in the peer group based on
the fact that LifeCell,  a developer of tissue  engineered  products,  is also a
biomedical company,  and selected Closure Medical based on the fact that Closure
Medical  markets tissue  adhesive  products.  The returns for the peer group are
weighted according to each issuer's market capitalization. The performance graph
shows total return on investment for the period beginning  December 31, 1995 and
ending December 31, 2000.





                                 [GRAPH OMITTED]








                     ASSUMES $100 INVESTED ON JAN. 01, 1996
                          ASSUMES DIVIDENDS REINVESTED
                           FISCAL YEARS ENDING DEC. 31


                 VALUE OF $100 INVESTED ON DECEMBER 31, 1995 AT:


                                                                              

                             12/31/95      12/31/96      12/31/97       12/31/98      12/31/99     12/31/00
                            ------------  ------------  ------------   ------------  -----------  ------------
CRYOLIFE                  $      100.00 $      161.29 $      175.81  $      153.22 $     151.61 $      585.19
PEER GROUP                $      100.00 $       95.97 $      160.72  $      136.00 $      69.02 $      101.21
RUSSELL 2000 INDEX        $      100.00 $      116.61 $      142.66  $      138.66 $     165.82 $      158.66



                 Total return assumes reinvestment of dividends.

EXECUTIVE COMPENSATION

     The following table sets forth the compensation paid or accrued by CryoLife
to  CryoLife's  Chief  Executive  Officer  and the four other most  highly  paid
executive officers of CryoLife in 2000 (the "Named Executives"). The information
presented is for the years ended  December 31,  2000,  1999 and 1998.  All share
amounts  have been  adjusted  to  reflect  the  Company's  3-for-2  stock  split
effective on December 27, 2000.


                                       10


                           SUMMARY COMPENSATION TABLE



                                                                                      

                                                                                    Long -Term
                                                        Annual Compensation        Compensation
                                                      -------------------------    --------------
                                                                                    Securities
                                                                                    Underlying         All Other
              Name and                                  Salary       Bonus         Options/SARs       Compensation
         Principal Position               Year         ($) (1)        ($)             (#) (2)           ($) (3)
- --------------------------------------    --------                                 --------------    ---------------
                                                      -------------------------
Steven G. Anderson                        2000      $    520,000    $  300,000            30,000     $       27,638
    Chairman of the Board of              1999           442,750       225,000                 0             27,388
    Directors, President and Chief        1998           385,000       175,000            58,500             27,361
    Executive Officer

Kirby S. Black, Ph.D.                     2000           176,165        70,000            22,500             10,912
    Vice President, Research and          1999           151,325        50,000                 0             11,919
    Development                           1998           122,850        40,000                 0              9,011

Albert E. Heacox, Ph.D.                   2000           184,800        60,000            15,000             14,985
    Vice President, Laboratory            1999           168,000        50,000                 0              7,235
    Operations                            1998           152,250        42,000                 0              7,894

Gerald B. Seery (4)                       2000           155,547        30,000            15,000              3,521
    Vice President, Marketing             1999           146,975        30,000                 0              3,674
                                          1998           131,250        30,000                 0              3,268

James C. Vander Wyk, Ph.D.                2000           174,625        60,000            15,000             13,429
    Vice President, Regulatory            1999           149,961        48,000            10,000              2,752
    Affairs and Quality Assurance         1998           131,250        40,000                 0              2,503




- -----------------

(1)    Includes  base  salary  earned by the Named  Executives  for the  periods
       presented and includes  compensation  deferred  under  CryoLife's  401(k)
       plan,   and  amounts  such  officers   elected  to  apply  to  CryoLife's
       supplemental  life insurance  program.  Amounts for perquisites and other
       personal  benefits  extended  to the Named  Executives  are less than the
       lesser of $50,000 or 10% of the total of annual  salary and bonus of such
       Named Executive.
(2)    During the periods  presented,  the only form of  long-term  compensation
       utilized by CryoLife  has been the grant of stock  options.  CryoLife has
       not awarded  restricted stock or stock  appreciation  rights, or made any
       long-term  incentive  payouts.  Accordingly,  the columns for "Restricted
       Stock Award(s)" and "Long Term Incentive Payouts" have been omitted.
(3)    Since the inception of CryoLife's 401(k) plan, CryoLife has been matching
       contributions  to the plan  subject to certain  limitations  and  vesting
       requirements.  In 1992,  CryoLife adopted its supplemental life insurance
       program for certain executive officers.
(4)    Effective  March 16, 2001, Mr. Seery ceased  serving  as Vice  President,
       Marketing of CryoLife by transferring to  the  position  of  President of
       AuraZyme Pharmaceuticals, Inc., a wholly-owned subsidiary of CryoLife.


                                       11




       The following  table sets forth,  for each of the Named  Executives,  the
amount of CryoLife's  contributions to the 401(k) plan and the supplemental life
insurance program:



                                                                                            


                                    2000                                  1999                                 1998
                     ------------------------------------  ----------------------------------- -------------------------------------
                                            SUPPLEMENTAL   TOTAL                SUPPLEMENTAL   TOTAL                   SUPPLEMENTAL
                                 401(K)         LIFE                401(K)          LIFE                   401(K)          LIFE
                       TOTAL   CONTRIBUTION  INSURANCE            CONTRIBUTION   INSURANCE              CONTRIBUTION    INSURANCE
                                              PROGRAM                             PROGRAM                                PROGRAM
                      -------- ------------ -------------  ------ ------------ --------------- -------  ------------- --------------
Steven G. Anderson   $ 27,638      $ 5,250     $  22,388 $ 27,388  $ 5,000       $ 22,388    $ 27,361    $ 4,973        $ 22,388
   Ph.D.
Kirby S. Black, Ph.D.  10,912        1,741         9,171   11,919    2,748          9,171       9,011      2,547           6,464
Albert E. Heacox,      14,985        4,235        10,750    7,235    3,504          3,731       7,894      3,743           4,151
   Ph.D.
Gerald B. Seery         3,521        3,521             0    3,674    3,674             0        3,268      3,268                0
James C. Vander        13,429        4,299         9,130    2,752    2,752             0        2,503      2,503                0
   Wyk, Ph.D.



     Grant of Options.  During 2000, options were granted to Steven G. Anderson,
Kirby S. Black,  Ph.D.,  Albert E. Heacox,  Ph.D.,  Gerald B. Seery and James C.
Vander Wyk,  Ph.D.  No stock  appreciation  rights  (SARs) have been  granted by
CryoLife.  The following  table sets forth  information  regarding the grants of
options in 2000:

                  OPTION/SAR GRANTS IN LAST FISCAL YEAR (2000)


                                                                                      


                                   Number of
                                   Securities
                                   Underlying    % of Total
                                   Options/     Options/SARs
                                     SARs        Granted to     Exercise                Potential Realizable Value
                                   Granted      Employees in     Price     Expiration   at Assumed Annual Rates of
              Name                    (#)       Fiscal Year    ($/Sh)(1)    Date(2)    Appreciation for Option Term
                                                                                       -----------------------------
                                                                                          5%($)           10%($)
 --------------------------------  ----------  --------------- ----------- ----------  -----------------------------
 Steven G. Anderson................14,085(3)        3.5          $29.15      12/7/10    $258,210.14     $654,355.19
                                      915(3)        0.2          $29.15      12/7/10     $16,774.03      $42,508.70
                                   15,000(4)        3.7          $11.50      5/26/10    $106,534.32     $272,970.57
 Kirby S. Black, Ph.D. ............22,500(5)        5.6          $11.63     11/26/05     $76,785.96     $175,555.28
 Albert E. Heacox, Ph.D. ..........15,000(5)        3.7          $11.63     11/26/05     $51,190.64     $117,036.86
 Gerald B. Seery...................15,000(6)        3.7          $29.15       6/7/06    $134,547.08     $301,220.05
 James C. Vander Wyk, Ph.D. .......15,000(7)        3.7          $29.15       6/7/07    $163,136.94     $375,067.05



- -------------

(1)     The  exercise  price was  fixed as the mean of  the high and low  market
        price on the date of grant.
(2)     Options are subject  to  earlier  termination  in  the  event of  death,
        disability, retirement, or termination of employment.
(3)     The options vest on January 1, 2010.
(4)     As to 8,695 shares,  the options vest and become  exercisable on January
        1, 2009 and as to 6,305 shares,  the options vest on January 1, 2010.
(5)     The  options  vest and become  exercisable  on each  anniversary  of the
        grant  date  in  the  amount of 20% of the total  shares granted on each
        vesting date.
(6)     The options  vest and  become  exercisable  on each  anniversary  of the
        grant date in the  following  amounts:  as to 2,503 shares, on the first
        anniversary, as to  2,504 shares, on the second anniversary, as to 3,450
        shares,  on the  third  anniversary,  as to 3,432 shares,  on the fourth
        anniversary and as to 3,132 shares, on the fifth anniversary.
(7)     The options  vest  and become  exercisable  on each  anniversary  of the
        grant date as follows:  as  to 805 shares, on the first anniversary,  as
        to 2,556 shares, on each  of the second, third and fourth anniversaries,
        as to 3,431 shares, on  the fifth anniversary and as to 3,096 shares, on
        the sixth anniversary.


                                       12


     Options Exercised. The following table sets forth information regarding the
exercise  of  options  in 2000  and the  number  of  options  held by the  Named
Executives as listed in the Summary  Compensation Table,  including the value of
unexercised  in-the-money options, as of December 31, 2000. The closing price of
CryoLife's  common stock on December 29, 2000 used to calculate  such values was
$30.25 per share.

           AGGREGATED OPTION/SAR EXERCISES IN LAST FISCAL YEAR (2000)
         AND FISCAL YEAR-END OPTION/SAR VALUES (AS OF DECEMBER 31, 2000)



                                                                                      
                                                             NUMBER OF SECURITIES            VALUE OF UNEXERCISED
                                                            UNDERLYING UNEXERCISED               IN-THE-MONEY
                                                                 OPTIONS/SARs                    OPTIONS/SARs
                                                                AT YEAR END (#)                 AT YEAR END ($)
                                                            ------------------------     ------------------------------
                                SHARES         VALUE
                              ACQUIRED ON
                               EXERCISE       REALIZED
           NAME                   (#)           ($)         EXERCISABLE  UNEXERCISABLE   EXERCISABLE      UNEXERCISABLE
- ---------------------------   ------------    ---------     ----------   -----------     ----------       -------------
Steven G. Anderson......           36,000  $    396,360        18,300       111,450    $   390,885      $    1,867,612
Kirby S. Black, Ph.D....           45,000       618,750             0        22,500    $         0      $      418,950
Albert E. Heacox, Ph.D.            45,000     1,262,970             0        15,000    $         0      $      279,300
Gerald B. Seery.........           55,000       583,485         3,000        21,000    $    63,750      $      144,000
James C. Vander Wyk, Ph.D.            ---           ---        39,000        36,000    $   950,130      $      498,720
 ........



     Long-Term  Incentive  Plan.  On December 19,  1997,  the Board of Directors
adopted,  subject to approval  of  shareholders,  the  CryoLife  1998  Long-Term
Incentive  Plan. As amended in 2000, the 1998 Long-Term  Incentive Plan provides
for the grant of options,  stock appreciation rights and other awards to acquire
up  to a  maximum  of  900,000  shares  of  common  stock,  subject  to  certain
adjustments.  As of March 16, 2001,  options for 710,250 shares were outstanding
and options for 5,250 shares had been  exercised.  Options may be granted  under
the 1998  Long-Term  Incentive  Plan to employees,  officers or directors of and
consultants and advisors to CryoLife and its  subsidiaries.  CryoLife  estimates
that, as of March 21, 2001, approximately 320 employees (including officers) and
five non-officer  directors of CryoLife were eligible to participate in the 1998
Long-Term  Incentive  Plan.  Unless  sooner  terminated  by the Board,  the 1998
Long-Term Incentive Plan terminates in May 2008. Stock options granted under the
Plan also usually expire upon  termination of employment or shortly  thereafter.
In the  event of a  "change  of  control  transaction"  as  defined  in the 1998
Long-Term  Incentive Plan,  limitations on exercisability of stock options owned
by executive  officers shall be waived, and the limitations on exercisability of
stock  options  owned  by  others  may  be  waived  in  the  discretion  of  the
Compensation Advisory Committee.

     CryoLife Amended and Restated Non-Employee Directors Stock Option Plan. The
CryoLife Amended and Restated Non-Employee  Directors Stock Option Plan provides
for the grant of  options  to  non-employee  directors  of  CryoLife.  This plan
provides  for the grant of options to acquire up to a maximum of 262,500  shares
of common  stock.  At each Annual  Meeting of  Shareholders,  each  non-employee
director  elected,  re-elected  or  continuing  as a  non-employee  director  of
CryoLife  receives an annual  grant of options to purchase  7,500  shares on the
first  business  day after such Annual  Meeting,  which  options  shall vest and
become  exercisable  on the date of grant.  Except as set forth  below,  options
granted under this plan are not  transferable  other than by will or the laws of
descent and  distribution.  Notwithstanding  the  foregoing,  the  optionee  may
transfer  the option for no  consideration  to or for the benefit of a member of
the optionee's  immediate family (including,  without limitation,  to a trust or
IRA) subject to such limits as the Board may establish, and the transferee shall
remain  subject to all the terms and  conditions  that were  applicable  to such
option prior to the transfer. Upon the death of a non-employee director, options
which were  exercisable on the date of death are exercisable by his or her legal
representatives  or heirs, but in no event may the option be exercised after the
last day on which it could have been exercised by the non-employee  director. As
of December 31,  2000,  options for 105,000  shares had been granted  under this
plan.

     Employment Agreements. CryoLife has entered into employment agreements with
each of the Named  Executives.  Except for Mr. Anderson's  agreement,  and other
than with respect to position  specific terms,  such as duties of employment and
compensation,  these  employment  agreements  are  substantially  identical  and
provide that  employment may be terminated by either party with or without cause
upon  30  days'  written  notice  to the  other.  The  agreements  automatically
terminate upon death. Each employee is required to devote his full and exclusive
time and attention to his employment  duties, and CryoLife reserves the right to
change the nature and scope of those duties. The agreement conditions employment
and continued employment upon the employee's signing CryoLife's standard Secrecy
and Noncompete Agreement.
                                       13


     A new  employment  agreement  with Mr.  Anderson was negotiated in February
1999 for a term of five years,  which replaces a similar contract  negotiated in
1995. The Compensation  Advisory Committee approved the inclusion of a provision
in the  agreement  pursuant  to which Ms.  Ann B.  Anderson,  the  spouse of Mr.
Anderson,  would be provided with health care coverage  throughout her life. The
agreement provides that either party may terminate Mr. Anderson's  employment by
giving 180 days' written  notice to the other.  The  termination  may be with or
without cause. In the event CryoLife  terminates  employment  without cause, Mr.
Anderson  will be entitled to be paid for the  remainder  of his term or for two
years,  whichever is greater.  If the  termination is with cause,  after the 180
days' notice period no additional compensation is due.

     Compensation Advisory Committee Interlocks and Insider  Participation.  The
following  four  directors  serve  on the  Compensation  Advisory  Committee  of
CryoLife's  Board of Directors:  Mr.  McCall,  Ms. Lacy,  Dr. Elkins and Dr. Van
Dyne.  Mr.  McCall has been  Secretary  and  Treasurer  of CryoLife  since 1984.
CryoLife has engaged  Ronald D. McCall,  P.A., a law firm of which Mr. McCall is
the sole shareholder to perform legal services on an ongoing basis. For the year
ended  December 31, 2000,  CryoLife  paid Ronald D. McCall,  P.A.  approximately
$76,275 for such legal services,  including expense  reimbursements.  Management
believes  that  these  services  were  provided  on terms no less  favorable  to
CryoLife than terms  available from unrelated  parties for comparable  services.
See  "Information  about the Board of Directors  and  Committees  of the Board -
Director Compensation"  regarding consulting fees paid by CryoLife to Dr. Elkins
and Dr. Van Dyne during fiscal 2000.

SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     Section 16(a) of the  Securities  Exchange Act of 1934 requires  CryoLife's
executive  officers and directors and persons who beneficially own more than 10%
of CryoLife's  stock to file initial reports of ownership and reports of changes
in ownership with the Securities and Exchange  Commission.  Executive  officers,
directors and greater than 10% beneficial owners are required by SEC regulations
to furnish CryoLife with copies of all Section 16(a) forms they file.

     Based  solely on its review of copies of forms  received  by it pursuant to
Section 16(a) of the Securities Exchange Act of 1934 or written  representations
from reporting persons, CryoLife believes that with respect to 2000, all Section
16(a) filing requirements  applicable to its executive  officers,  directors and
greater than 10% beneficial owners were complied with except as follows: John M.
Cook, one of CryoLife's  directors,  filed a delinquent  Form 4 in March 2001 to
report four  purchases  of  CryoLife's  Common  Stock made in March  2000.  Such
purchases  were made by CT  Investments,  LLC of which Mr.  Cook owns 90% of the
membership interests.


                                       14




             OWNERSHIP OF PRINCIPAL SHAREHOLDERS, NAMED EXECUTIVES,
                 AND EXECUTIVE OFFICERS AND DIRECTORS AS A GROUP


       The name and address of each person or entity who owned  beneficially  5%
or more of the outstanding shares of common stock of CryoLife on March 16, 2001,
together  with the  number of shares  owned and the  percentage  of  outstanding
shares that ownership  represents is set forth in the following table. The table
also shows  information  concerning  beneficial  ownership  by each of the Named
Executives and by all directors and executive officers as a group. The number of
shares  beneficially  owned is  determined  under the rules of the SEC,  and the
information is not necessarily  indicative of beneficial ownership for any other
purpose. Under such rules,  beneficial ownership includes any shares as to which
the individual has sole or shared voting power or investment  power and also any
shares which the  individual  has the right to acquire  within 60 days after the
date hereof  through the  exercise of any stock  option or other  right.  Unless
otherwise  indicated,  each person has sole  investment  and voting  powers,  or
shares such powers with his or her spouse,  with respect to the shares set forth
in the following table:



                                                                             


                                                                                   Percentage of
                                                         Number of Shares of        Outstanding
                                                           CryoLife Stock            Shares of
                         Beneficial Owner                Beneficially Owned        CryoLife Stock
- ---------------------------------------------------     ----------------------    -----------------
Steven G. Anderson.................................              1,757,167(1)          9.36%
Kirby S. Black, Ph.D...............................                 51,388(2)            *
Albert E. Heacox, Ph.D.............................                120,396(3)            *
Gerald B. Seery....................................                 37,800(4)            *
James C. Vander Wyk, Ph.D. ........................                 48,000(5)            *
Scudder Kemper Investments, Inc....................              1,970,100(6)          10.51%
All current Directors and Executive Officers
     as a group (14 persons).......................              3,281,594(7)          16.97%
- ------------------


* Ownership represents less than 1% of outstanding CryoLife common stock.

(1)  Includes  157,999  shares  held  of  record  by Ms.  Ann B.  Anderson,  Mr.
     Anderson's spouse. Also includes 27,000 shares subject to options which are
     presently  exercisable or will become  exercisable within 60 days after the
     date of this proxy statement. The business address for Mr. Anderson is: c/o
     CryoLife, Inc., 1655 Roberts Blvd., N.W., Kennesaw, Georgia 30144.
(2)  Includes  4,500  shares  subject  to  options  which are  either  presently
     exercisable  or will  become  exercisable  within 60 days after the date of
     this proxy  statement.  Also includes 225 shares held by Dr.  Black's minor
     children.
(3)  Includes  3,000  shares  subject  to  options  which are  either  presently
     exercisable  or will  become  exercisable  within 60 days after the date of
     this proxy  statement.  Also includes  45,000 shares owned by Dr.  Heacox's
     spouse as trustee of a living trust and 72,396  shares owned by Dr.  Heacox
     as trustee of a living trust.
(4)  Includes  3,000  shares  subject  to  options  which are  either  presently
     exercisable  or will  become  exercisable  within 60 days after the date of
     this proxy statement.
(5)  Includes  39,200  shares  subject  to options  which are  either  presently
     exercisable  or will  become  exercisable  within 60 days after the date of
     this proxy statement.
(6)  The  business  address of Scudder  Kemper  Investments,  Inc.  is: 345 Park
     Avenue,  New York,  New York 10154.  Based on  Schedule  13G filed with the
     Securities and Exchange Commission on February 14, 2001.
(7)  See "Election of Directors" for information as to the beneficial  ownership
     of  shares  attributed  to  directors  who are not also  Named  Executives.
     Includes 591,199 shares subject to options which are presently  exercisable
     or will  become  exercisable  within 60 days  after the date of this  proxy
     statement. Includes 117,396 shares held as trustees by an executive officer
     and his  spouse.  Includes  358,450  shares  held as  beneficiary  of three
     trusts,  and 165,879  shares held as  beneficiary  of an IRA, of Ms. Lacy's
     deceased spouse.  Includes 22,500 shares held as administrator of a pension
     plan.  Includes  173,999  shares held of record by the spouses of executive
     officers and directors.

                                       15


                         INDEPENDENT PUBLIC ACCOUNTANTS

     The  accounting  firm of  Arthur  Andersen  LLP has  been  the  independent
certified public accountants of CryoLife since May, 1999.  Approval or selection
of the independent  certified public accountants of CryoLife is not submitted to
the  shareholders at the Annual Meeting.  The Board of Directors of CryoLife has
historically  selected the independent  certified public accountants of CryoLife
with the advice of the Audit Committee,  and the Board believes that it would be
to  the  detriment  of  CryoLife  and  its  shareholders  for  there  to be  any
impediment,  such as  selection  or  ratification  by the  shareholders,  to its
exercising  its  judgment  to select  CryoLife's  independent  certified  public
accountants  or to remove them if, in its  opinion,  such removal is in the best
interest of CryoLife and its shareholders.

     It is anticipated that a representative  from the accounting firm of Arthur
Andersen  LLP will be present at the annual  meeting of  shareholders  to answer
questions and make a statement if the representative desires to do so.

     On May 27, 1999, at the recommendation of the Audit Committee, the Board of
Directors  of CryoLife  engaged the  accounting  firm of Arthur  Andersen LLP as
independent  auditors  for  CryoLife.  Arthur  Andersen LLP replaces the firm of
Ernst & Young LLP,  whose  engagement  expired and was not renewed by CryoLife's
Board of Directors,  also based on the  recommendation  of the Audit  Committee,
effective  as of May 27,  1999.  Ernst  & Young  LLP  was  notified  that  their
engagement would not be renewed on June 1, 1999.

     Neither CryoLife nor anyone engaged on its behalf has consulted with Arthur
Andersen LLP since the  beginning of CryoLife's  fiscal year ended  December 31,
1997 with regard to (i) either:  the  application of accounting  principles to a
specified  transaction,  either  completed  or  proposed;  or the  type of audit
opinion that might be rendered on CryoLife's  financial  statements which Arthur
Andersen LLP has  concluded  was an important  factor  considered by CryoLife in
reaching a decision  as to the  accounting,  auditing,  or  financial  reporting
issue;  or (ii) any matter  that was either the  subject of a  disagreement  (as
defined in Item  304(a)(1)(iv)  of  Regulation  S-K) or a  reportable  event (as
described in Item 304(a)(1)(v) of Regulation S-K).

     There  were no  disagreements  between  CryoLife  and  Ernst & Young LLP in
connection  with the audits of the two most recent  fiscal years ended  December
31,  2000 and  1999,  on any  matter  of  accounting  principles  or  practices,
financial  statement  disclosure,   or  auditing  scope  or  procedures,   which
disagreements  if not  resolved to their  satisfaction  would have caused  Ernst
&Young LLP to make  reference in  connection  with their  reports to the subject
matter of the  disagreement.  In addition,  no events of the type  referenced in
paragraphs  (a) (1) (v) (A) through (D) of Item 304 of  Regulation  S-K occurred
within CryoLife's two most recent fiscal years or within the subsequent  interim
period through May 27, 1999.

     The  audit  reports  of  Ernst & Young  LLP on the  consolidated  financial
statements of CryoLife as of and for the years ended  December 31, 2000 and 1999
did not contain  any adverse  opinion or  disclaimer  of opinion,  nor were they
qualified or modified as to uncertainty, audit scope, or accounting principles.

     On June 8, 1999, CryoLife received a letter of Ernst & Young LLP dated June
7, 1999.  This letter was filed with the Securities  and Exchange  Commission as
Exhibit 16 to CryoLife's Current Report on Form 8-K/A dated May 22, 1999.

                              SHAREHOLDER PROPOSALS

     Appropriate   proposals  of  shareholders   intended  to  be  presented  at
CryoLife's  2002  Annual  Meeting  of   Shareholders   pursuant  to  Rule  14a-8
promulgated  under  the  Securities  Exchange  Act of 1934 must be  received  by
CryoLife by December 5, 2001 for  inclusion in its proxy  statement  and form of
proxy relating to that meeting. In addition, all shareholder proposals submitted
outside of the  shareholder  proposal rules  promulgated  pursuant to Rule 14a-8
under the Exchange  Act must be received by CryoLife by February  18,  2002,  in
order to be  considered  timely.  If such  shareholder  proposals are not timely
received,  proxy holders will have discretionary voting authority with regard to
any such shareholder proposals which may come before the 2002 Annual Meeting. If
the date of the next  annual  meeting  is  advanced  or  delayed by more than 30
calendar days from the date of the annual meeting to which this proxy  statement
relates,  CryoLife  shall,  in a timely manner,  inform its  shareholders of the
change, and the date by which proposals of shareholders must be received.

                                       16


     Upon The Written Request Of Any Record Or Beneficial  Owner Of Common Stock
Of CryoLife Whose Proxy Was Solicited In Connection With The 2001 Annual Meeting
Of Shareholders, CryoLife Will Furnish Such Owner, Without Charge, A Copy Of Its
Annual Report On Form 10-K Without  Exhibits For Its Fiscal Year Ended  December
31,  2000.  Request  For A Copy Of Such  Annual  Report On Form  10-K  Should Be
Addressed To Suzanne Gabbert, Assistant Secretary,  CryoLife, Inc., 1655 Roberts
Boulevard, N.W., Kennesaw, Georgia 30144.

     It Is Important That Proxies Be Returned Promptly.  Shareholders Who Do Not
Expect To Attend The  Meeting In Person  Are Urged To Sign,  Complete,  Date And
Return  The Proxy Card In The  Enclosed  Envelope,  To Which No Postage  Need Be
Affixed.

                                      By Order of the Board of Directors

                                      /s/ Steven G. Anderson

                                      STEVEN G. ANDERSON, Chairman
                                      of the Board, President and Chief
Dated:  April 4, 2001                 Executive Officer

                                       17



                                                                      APPENDIX A


                                     CHARTER
                                 AUDIT COMMITTEE
                                 CRYOLIFE, INC.


ORGANIZATION

     There shall be a  committee  of the board of  directors  to be known as the
Audit  Committee.  The  Audit  Committee  shall be  composed  of at least  three
directors who are free of any relationship  that, in the opinion of the board of
directors,  would interfere with their exercise of independence  from management
and the Company as a committee member. In addition,  each Audit Committee member
shall be  financially  literate,  as such  qualification  is  interpreted by the
Company's Board of Directors in its business judgment or must become financially
literate within a reasonable  period of time after his or her appointment to the
Audit Committee. At least one member of the Audit Committee must have accounting
or related financial management expertise,  as the Board of Directors interprets
such qualification in its business judgment.

STATEMENT OF POLICY

     The Audit Committee shall provide assistance to the corporate  directors in
fulfilling their responsibility to the shareholders, potential shareholders, and
investment  community relating to corporate  accounting,  reporting practices of
the corporation,  and the quality and integrity of the financial  reports of the
corporation.  In so doing,  it is the  responsibility  of the Audit Committee to
maintain  free and open  means  of  communication  between  the  directors,  the
independent auditors and the financial management of the corporation.

RESPONSIBILITIES

     In carrying  out its  responsibilities,  the Audit  Committee  believes its
policies  and  procedures  should  remain  flexible,  in order to best  react to
changing  conditions  and to ensure to the directors and  shareholders  that the
corporate   accounting  and  reporting  practices  of  the  corporation  are  in
accordance with all requirements and are of the highest quality.

     In carrying out these responsibilities, the Audit Committee will:

     1.   Review and recommend to the directors the  independent  auditors to be
          selected to audit the financial  statements of the corporation and its
          divisions and  subsidiaries.  The  accountability  of the  independent
          auditor  is to the Audit  Committee  and the Board of  Directors.  The
          Audit  Committee  has  the  responsibility  to  select,  evaluate  and
          recommend  to the Board of Directors  the  independent  auditors.  The
          Audit Committee is responsible for ensuring auditor independence.

     2.   Meet with the  independent  auditors and  financial  management of the
          corporation  to review the scope of the proposed audit for the current
          year and the audit  procedures to be utilized,  and at the  conclusion
          thereof review such audit,  including any comments or  recommendations
          of the independent auditors.

     3.   Review with the independent auditors, and the financial and accounting
          personnel  of the  Company,  the  quality and  adequacy  of  financial
          statements  and  financial   disclosures  and   effectiveness  of  the
          accounting and financial  controls of the corporation,  and elicit any
          recommendations   for  the   improvement  of  such  internal   control
          procedures or particular areas where new or more detailed  controls or
          procedures are desirable.  Particular  emphasis should be given to the
          adequacy  of  such   internal   controls   to  expose  any   payments,
          transactions,  or procedures that might be deemed illegal or otherwise
          improper.  Further,  the committee  periodically should review Company
          policy statements to determine their adherence to the code of conduct.




     4.   Obtain  and  review on a  periodic  basis  statements  of the  outside
          auditor  delineating  all  relationships  between  the auditor and the
          Company and  actively  engage the outside  auditor in a dialogue  with
          respect  to any  relationships  or  services  that may  impact  on the
          objectivity and independence of the outside auditor and recommend that
          the Board of  Directors  take  appropriate  action in  response to the
          outside  auditors  report to satisfy  itself of the  outside  auditors
          independence.

     5.   Review the  financial  statements  contained  in the annual  report to
          shareholders with management and the independent auditors to determine
          that the  independent  auditors are satisfied  with the disclosure and
          content  of  the   financial   statements   to  be  presented  to  the
          shareholders. Any changes in accounting principles should be reviewed.
          The  Audit   Committee  will  notify   shareholders  in  annual  proxy
          statements   that  financial   statements   have  been  reviewed  with
          management  and the  independent  auditors and that the  Committee has
          assessed  the  auditors  independence  and  recommended  the filing of
          financial  statements with the Form 10K. The Audit Committee will have
          discussions  with  independent  auditors  concerning  the  quality  of
          financial  reporting and the fairness of the presentation of financial
          statements prior to filing of Form 10K.

     6.   Provide  sufficient  opportunity for the independent  auditors to meet
          with the members of the Audit Committee  without members of management
          present.  Among the items to be  discussed  in these  meetings are the
          independent  auditors'  evaluation  of  the  corporation's  financial,
          accounting,  and  auditing  personnel,  and the  cooperation  that the
          independent auditors received during the course of the audit.

     7.   Submit  the  minutes of all  meetings  of the Audit  Committee  to, or
          discuss the matters  discussed at each  committee  meeting  with,  the
          board of directors.

     8.   Investigate  any matter  brought to its attention  within the scope of
          its duties,  with the power to retain  counsel for this purpose if, in
          its judgment, that is appropriate.


     ADOPTED MAY 26, 2000






                                 CRYOLIFE, INC.
               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                  FOR USE AT THE ANNUAL MEETING ON MAY 17, 2001

     The undersigned  shareholder  hereby appoints STEVEN G. ANDERSON and RONALD
D. McCALL, or any of them, with full power of substitution, to act as proxy for,
and to vote the stock of, the  undersigned at the Annual Meeting of Shareholders
of CRYOLIFE, INC. to be held on May 17, 2001, and any adjournments thereof.

     The  undersigned  acknowledges  receipt of Notice of the Annual Meeting and
Proxy Statement, each dated April 4, 2001, and grants authority to said proxies,
or their  substitutes,  and  ratifies  and  confirms  all that said  proxies may
lawfully  do in  the  undersigned's  name,  place  and  stead.  The  undersigned
instructs said proxies to vote as indicated below and on the reverse hereof.

                    FOR election of    REFRAIN FROM
                    the individuals     VOTING FOR
                      set forth at      election of
                     right (except     the nominees
                      as marked to     set forth at
                     the contrary)         right


                                                                               
1.  ELECTION OF                                        Nominees:                     2.  Upon  such  other  matters as
     DIRECTORS            -----             -----                                        may  properly come before the
                                                       Steven G. Anderson                meeting.

                                                       John M. Cook                      THE  PROXIES   SHALL  VOTE  AS
                                                                                         SPECIFIED   ABOVE,  OR  IF  NO
(INSTRUCTIONS):      To     withhold                   Ronald C. Elkins, M.D.            DIRECTION IS  MADE, THIS PROXY
authority    to    vote    for   any                                                     WILL BE VOTED  FOR EACH OF THE
individual  nominee(s),  write  that                   Virginia C. Lacy                  LISTED NOMINEES
person's name on the space  provided
below                                                  Ronald D. McCall, Esq.
- ---------------------------------------
                                                       Alexander C. Schwartz, Jr.        PLEASE  VOTE,  SIGN,  DATE AND
                                                                                         RETURN    THIS    PROXY   CARD
                                                       Bruce J. Van Dyne, M.D.           PROMPTLY  USING  THE  ENCLOSED
                                                                                         ENVELOPE.





Signature      _________________________      Date__________________
Signature      _________________________      Date__________________


NOTE:(Shareholders  should sign exactly as name appears on stock.  When there is
     more than one owner each should sign. Executors,  Administrators,  Trustees
     and others signing in a representative capacity should so indicate.)



                         (continued on the reverse side)

                 Please Detach and Mail in the Envelope Provided

                         Please date, sign and mail your
                      proxy card back as soon as possible!


                        Annual Meeting of Shareholders of
                                 CRYOLIFE, INC.
                                  May 17, 2001
                                       at
                        Sheraton Suites Galleria-Atlanta
                              2844 Cobb Parkway, SE
                             Atlanta, Georgia 30339
                                   10:00 a.m.





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