EXHIBIT 10.12

                            EIGHTH AMENDMENT TO LEASE

     THIS AGREEMENT,  made and entered into this 18th day of November,  1998, by
and between  Newmarket  Partners III,  Limited,  a Georgia Limited  Partnership,
whose general partners are Laing Properties,  Inc. and Laing Management  Company
(hereinafter  called  "Landlord")  and  Cryolife,  Inc.,  a Florida  corporation
(hereinafter called "Tenant").

                                WITNESSETH THAT:

     WHEREAS,  Landlord and Tenant entered into a certain Lease  Agreement dated
February 13, 1986, as amended April 7, 1986, May 15, 1987, June 22, 1988,  April
4,  1989,  October  15,  1990,  March 14,  1995 and May 15,  1996  (collectively
hereinafter "Lease") for Suites 122 through 150 (hereinafter "Premises") at 2211
Newmarket Parkway, Building 8, Marietta, Georgia 30067.

     WHEREAS, Tenant desires to extend the Term of the Lease; and

     WHEREAS,  Landlord and Tenant  desire to amend the Lease in order to modify
some of the other terms and conditions of the Lease;

     NOW,   THEREFORE,   in  consideration  of  the  mutual  agreements  of  the
undersigned and other good valuable consideration, this Lease is hereby amended,
effective December 1, 1999 as follows:

48. BROKER DISCLOSURE

     Pursuant  to Georgia  Real Estate  Commission  Regulation  520-1-08,  Laing
     Marketing  Company makes the following  disclosures  concerning  this Lease
     transaction:

     a)   In this transaction,  Laing Marketing Company represents  Landlord and
          not Tenant.

     b)   In this transaction,  Richard Bowers and Company represents Tenant and
          not Landlord.

     c)   In this  transaction,  both Laing Marketing Company and Richard Bowers
          and  Company   shall   receive   their   compensation   from  Landlord
          exclusively.

     Both  Tenant  and  Landlord  acknowledge,  agree  with and  consent  to the
     representation and compensation disclosed above.

49. Paragraph 2, Term, of the Lease shall be amended to read:

     To have and to hold the same for the term to  commence  on December 1, 1999
     and ending on the 30th day of November,  2001,  at midnight  unless  sooner
     terminated as hereinafter provided.

50. Paragraph 3, Rental, of the Lease shall be amended to read:

     The Tenant agrees to pay to the Landlord  promptly on the first day of each
     month in  advance,  during  the term of this  Lease,  a  monthly  rental as
     follows:

          December 1, 1999  through  November  30, 2000 @  $14,849.84  per month
          December 1, 2000 through November 30, 2001 @ $15,295.33 per month

     Payments  received  after the tenth  day of the  month may be  assessed  an
     additional  five  percent  (5%)  charge as agreed  liquidated  damages  due
     Landlord. Acceptance by Landlord of a rental payment in an amount less than
     that which is currently due shall in no way affect  Landlord's rights under
     this Lease and in no way be an accord and satisfaction.




Page 2 of Eighth  Amendment  to Lease by and  between  Newmarket  Partners  III,
Limited,  a  Georgia  Limited  Partnership,  whose  general  partners  are Laing
Properties,  Inc. and Laing  Management  Company and  Cryolife,  Inc., a Florida
corporation, dated November 18, 1996.

51. RENEWAL OPTION

     A.   Tenant shall have the right to renew this Lease for one (1) additional
          term of one (1) year  commencing  on December 1, 2001 (such term being
          hereinafter  referred to as the "Renewal  Lease Term").  Said right of
          renewal  shall  be  subject,  however,  to  the  following  conditions
          precedent:

          1.   Tenant shall give Landlord written notice of its exercise of such
               renewal option at least six (6) months, but no more than nine (9)
               months, prior to the expiration of the Term;

          2.   Tenant shall not have been in default in  performance  of or with
               respect to any of the terms,  covenants,  and  conditions  of the
               Lease with  respect  to any matter as to which  notice of default
               has,  if  required,  been  given and which has not been  remedied
               within the time provided by the Lease; and

          3.   In  no  event  shall  such  renewal  rights  be  granted  to  any
               subtenant(s) or assignee(s) of Tenant.

     B.   All of the  terms,  covenants  and  conditions  of  this  Lease  shall
          continue  in full force and  effect  during the  Renewal  Lease  Term,
          except that the monthly rental shall be as follows:

               December  1, 2001  through  November  30, 2002 @  $15,754.19  per
               month.

          Except as herein amended,  all terms and conditions of the Lease shall
          remain in full force and effect.

     IN  WITNESS  WHEREOF,  the  parties  hereunto  have  executed  this  Eighth
Amendment to Lease as of the day and year first above written.


Signed, sealed and delivered     LANDLORD:  NEWMARKET  PARTNERS III, LIMITED,
in the presence of:              a  Georgia Limited  Partnership, whose  general
                                 partners  are Laing Properties, Inc. and
                                 Laing Management Company


                                 BY:  LAING PROPERTIES, INC.
                                      MANAGING GENERAL PARTNER


/s/ Felicia E. Trott             BY:/s/ Albert E. Heacox
- ---------------------------         ----------------------------------------
Witness

                                 TITLE:V.P. Laboratory Operations
                                       -------------------------------------

s/ Suzanne K. Gabbert            ATTEST:/s/ Ed B. Cordell
- ---------------------------             ------------------------------------
Notary Public

                                 TITLE:VP Finance
                                       -------------------------------------
Notary Public, Cobb County,                   (CORPORATE SEAL)
Georgia

My Commission Expires
Sept. 13, 2000




Page 3 of Eighth  Amendment  to Lease by and  between  Newmarket  Partners  III,
Limited,  a  Georgia  Limited  Partnership,  whose  general  partners  are Laing
Properties,  Inc. and Laing  Management  Company and  Cryolife,  Inc., a Florida
corporation, dated November 18, 1996.

Signed, sealed and delivered     TENANT:  CRYOLIFE, INC., a Florida
in the presence of:                       corporation


/s/ Felicia E. Trott             BY:/s/ Albert E. Heacox
- ---------------------------         ---------------------------------------
Witness

                                 TITLE:V.P. Laboratory Operations
                                       ------------------------------------

/s/ Suzanne K. Gabbert           ATTEST:/s/ Ed B. Cordell
- ---------------------------             -----------------------------------
Notary Public

                                 TITLE:VP Finance
                                       ------------------------------------
Notary Public, Cobb County,                  (CORPORATE SEAL)
Georgia

My Commission Expires
Sept. 13, 2000


Signed, sealed and delivered     LANDLORD:  NEWMARKET PARTNERS III,
in the presence of:              LIMITED, a Georgia Limited Partnership
                                 whose general partners are Laing Properties,
                                 Inc. and Laing Management Company


                                 BY:  Laing Properties, Inc.
                                      Managing General Partner


                                 BY:/s/James A. Gillespie
- ---------------------------         --------------------------------------
Witness

                                 TITLE:      V.P.
                                       -----------------------------------
/s/ Julie J. Waller
- ---------------------------
Notary Public
                                 ATTEST:     /s/ Robert R. Stubbs
                                        ----------------------------------

                                 TITLE:      Vice President & Secretary
                                       -----------------------------------

                                           (CORPORATE SEAL)
1545699v1