EXHIBIT 10.16


                            SECOND AMENDMENT TO LEASE

     THIS AGREEMENT,  made as of and entered as of this 6th day of June 1998, by
and between  Newmarket  Partners I, Ltd., a Georgia Limited  Partnership,  whose
general  partners  are  Laing  Properties,  Inc.  and Laing  Management  Company
(hereinafter  called  "Landlord")  and  Cryolife,  Inc.,  a Florida  corporation
(hereinafter called "Tenant").

                                WITNESSETH THAT:

     WHEREAS,  Landlord and Tenant entered into a certain Lease  Agreement dated
July 23, 1993, as amended June 9, 1994 (collectively,  hereinafter  "Lease") for
Suite 124,  Building 5,  (hereinafter  "Premises")  at 2121  Newmarket  Parkway,
Marietta, Cobb County, Georgia 30067.

     WHEREAS,  Landlord and Tenant  desire to amend the Lease in order to modify
some of the terms and conditions of the Lease; and

     WHEREAS, Tenant desires to extend the Term of the Lease an additional three
(3)  years for the  period of  November  16,  1998  through  November  15,  2001
(hereinafter "Renewal Term").

     NOW, THEREFORE in consideration of the mutual agreements of the undersigned
and  other  good and  valuable  consideration,  this  Lease is  hereby  amended,
effective November 16, 1998, as follows:

47.  BROKER DISCLOSURE

     Pursuant  to Georgia  Real Estate  Commission  Regulation  520-1-08,  Laing
Marketing  Company  makes  the  following  disclosures   concerning  this  Lease
transaction:

     a)   In this transaction,  Laing Marketing Company represents  Landlord and
          not Tenant.

     b)   In this  transaction,  Richard Bowers & Company  represents Tenant and
          not Landlord.

     c)   In this transaction, both Laing Marketing Company and Richard Bowers &
          Company shall receive their compensation from Landlord exclusively.

     Both  Tenant  and  Landlord  acknowledge,  agree  with and  consent  to the
representation and compensation disclosed above.

48.  ENVIRONMENTAL MATTERS

     Tenant will be subject to the provisions contained in Exhibit "E" entitled,
"Environmental  Matters',  attached  hereto  and by this  reference  made a part
hereof.

49.  TERM

     Paragraph 2, Term, of the Lease shall be amended to read:

     To have and to hold the same  for the  term to  commence  on the  sixteenth
     (16th)  day of  November  1998 and  ending on the  fifteenth  (15th) day of
     November  2001,  at  midnight,  unless  sooner  terminated  as  hereinafter
     provided.

50.  RENTAL

     Paragraph 3, Rental, of the Lease shall be amended to read:

     The Tenant agrees to pay to the Landlord  promptly on the first day of each
     month in advance, during the term of this Lease, a monthly rental of:

       November 16, 1998 through November 15, 1999 @ $7,952.46 per month
       November 16, 1999 through November 15, 2000 @ $8,270.56 per month
       November 16, 2000 through November 15, 2001 @ $8,601.38 per month




Page 2 of Second Amendment to Lease by and between Newmarket  Partners I Ltd., a
Georgia Limited Partnership,  whose general partners are Laing Properties,  Inc.
and Laing  Management  Company and Cryolife Inc., a Florida  corporation,  dated
June 6, 1998.

          Payments  received after the tenth day of the month may be assessed an
          additional five percent (5%) charge as agreed  liquidated  damages due
          Landlord. Acceptance by Landlord of a rental payment in an amount less
          than that which is  currently  due shall in no way  affect  Landlord's
          rights under this Lease and in no way be an accord and satisfaction.

51.  TENANT IMPROVEMENTS

     The Premises will be leased "as-is" during the Renewal Term and any and all
     improvements shall be at Tenant's sole cost and expense.

     Except as herein  amended,  all terms  and  conditions  of the Lease  shall
remain in full force and effect.

     IN  WITNESS  WHEREOF,  the  parties  hereunto  have  executed  this  Second
Amendment to Lease as of the day and year first above written.

Signed, sealed and delivered     LANDLORD: Newmarket Partners I, Ltd. a
in the presence of:                        Georgia Limited Partnership,
                                           whose general partners are Laing
                                           Properties, Inc. and Laing
                                           Management Company

                                  BY:      Laing Properties, Inc.
                                           Managing General Partner


/s/  Patricia L. Pendley          BY:      /s/  James A. Gillespie
- --------------------------                 -------------------------------------
Witness                                    James A. Gillespie

                                  TITLE:   Executive Vice President

/s/  Julie J. Waller              ATTEST:  /s/  Robert R. Stubbs
- --------------------------                 -------------------------------------
Notary Public                              Robert R. Stubbs

                                  TITLE:   Vice President & Secretary
                                           -------------------------------------
                                           (CORPORATE SEAL)

Signed, sealed and delivered      TENANT:  Cryolife, Inc., a Florida Corporation
in the presence of:

/s/  Felicia E. Trott             BY:      /s/  Albert E. Heacox
- --------------------------                 -------------------------------------
Witness
                                  TITLE:   V.P. Laboratory Operations
                                           -------------------------------------

/s/  Suzanne K. Gabbert           ATTEST:  /s/ Suzanne K. Gabbert
- --------------------------                 -------------------------------------
Notary Public
                                  TITLE:   Assistant Corporate Secretary
                                           -------------------------------------
Notary Public, Cobb County, Georgia                  (CORPORATE SEAL)
My Commission Expires:
September 13, 2000



                                       2




                                   EXHIBIT "E"
                              ENVIRONMENTAL MATTERS

A.   Tenant   covenants  that  it  will  not  cause  or  permit,   knowingly  or
     unknowingly,  any Hazardous  Wastes (as hereinafter  defined) to be brought
     upon, disposed on or stored in or on the Premises or any Hazardous Material
     (as  hereinafter  defined) to be released  in, on or about the Premises and
     that it will comply with any and all applicable  laws,  ordinances,  rules,
     regulations  and  requirements  respecting the presence,  use or release of
     Hazardous Materials in, on or about the Premises.

B.   Tenant covenants that it will immediately notify Landlord,  in writing,  of
     any existing,  pending or threatened (i) investigation,  inquiry,  claim or
     action by any governmental  authority in connection with any  Environmental
     Laws (as hereinafter  defined);  (ii) third party claims;  (iii) regulatory
     actions; and/or (iv) contamination of the Premises.

C.   Tenant shall, at Tenant's expense, investigate,  monitor, remediate, and/or
     clean up any Hazardous  Material,  Hazardous Waste, or other  environmental
     condition on, about, or under the Premises required as a result of Tenant's
     use or occupancy of the Premises.

D.   Tenant  covenants  that it shall keep the Premises free of any lien imposed
     pursuant to any Environmental Laws.

E.   Tenant shall indemnify,  defend and hold Landlord harmless from and against
     any and all claims, judgments,  damages, penalties, fines, costs (including
     without limitation, attorney's fees and court costs), liabilities or losses
     (collectively,  the "Tenant  Indemnified  Claims")  resulting  from (i) the
     presence  of  Hazardous  Wastes in or about the  Premises or the release of
     Hazardous  Materials  in, on or a bout the Premises on or after the date of
     this Lease, and (ii) any Hazardous Waste placed or any Hazardous  Materials
     released  elsewhere  in  Newmarket  Business  Park by Tenant,  its  agents,
     invitees, employees and contractors.

F.   The  provisions  of this  Exhibit  "E"  shall  survive  the  expiration  or
     termination of this Lease.

G.   For purposes of this Lease,  the term Hazardous  Waste has the same meaning
     as the term is defined in the Resource  Conservation  and Recovery  Act, as
     amended, 42 U.S.C.ss.6901 et. seq. ("RCRA").

H.   For the purposes of this Lease, the term Hazardous Material,  is defined to
     include  those  matters  described  in  the   Comprehensive   Environmental
     Response,  Compensation and Liability Act, as amended, 42 U.S.C.ss.9601 et.
     seq.  ("CERCLA").  As used herein the term Hazardous  Materials  shall also
     mean  (i)   asbestos,   or  any   substance   containing   asbestos;   (ii)
     polychlorinated  biphenyls;  (iii) lead; (iv) radon;  (v) pesticides;  (vi)
     petroleum  or  any  other  substance  containing  hydrocarbons;  (vii)  any
     substance which,  when on the Premises,  is prohibited by any Environmental
     Laws; and (viii) any other  substance,  material or waste which, (x) by any
     Environmental  Laws  requires  special  handling  or  notification  of  any
     governmental authority in its collection,  storage,  treatment, or disposal
     or (y) is defined or classified as hazardous,  dangerous or toxic  pursuant
     to any legal requirement.

I.   For  purposes of this  Lease,  Environmental  Laws shall mean:  any and all
     federal, state and local laws, statutes,  codes,  ordinances,  regulations,
     rules or other  requirements  relating to human  health or safety or to the
     environment including, but not limited to, those applicable to the storage,
     treatment,  disposal,  handling  and  release  of any  Hazardous  Waste  or
     Hazardous Materials, all as amended or modified from time to time.



                                       -i-


1545087