EXHIBIT 99.1

                                                                  [COMPANY LOGO]

FOR IMMEDIATE RELEASE

MICROTEK MEDICAL HOLDINGS REPORTS FIRST QUARTER 2003 RESULTS

COLUMBUS, MS, May 6, 2003 - Microtek Medical Holdings, Inc. (Nasdaq: MTMD) today
announced its results for the first quarter of 2003.  Highlights  from the first
quarter of 2003 as compared to the first quarter of 2002 are as follows:

     o    Net  revenues  increased  by $1.8  million  or 8.5  percent  to  $23.0
          million.  Net sales (net revenues excluding licensing revenues) in the
          first quarter of 2003 increased by $2.2 million or 10.4 percent.

     o    Net sales by the Company's  OREX  Technologies  International  ("OTI")
          division  increased  by $1.2  million  to $1.4  million  in the  first
          quarter of 2003,  aided  significantly  by nuclear  business  revenues
          which  increased by $1.1 million to $1.2 million in the first  quarter
          of 2003.

     o    Net income for the first quarter of 2003 increased by $869,000 or 65.4
          percent from the first  quarter of 2002.  This  increase in net income
          includes  approximately  $929,000  from the decrease in the  Company's
          valuation allowance for its deferred tax assets.

     o    EPS on a diluted  basis was $0.05 per share,  as compared to $0.03 per
          diluted  share for the first  quarter of 2002.  Included  in the first
          quarter 2003 EPS is $0.02 from the decrease in the Company's valuation
          allowance for its deferred tax assets.

Net income and earnings per basic and diluted  share for the 2003 first  quarter
were $2.2  million  and $0.05,  respectively,  as compared to net income of $1.3
million and earnings per basic and diluted  share of $0.03 in the first  quarter
of 2002.  Included in earnings  for the first  quarter of 2003 is  approximately
$929,000,  or $0.02 per basic and diluted share,  related to the decrease in the
Company's  valuation  allowance  for its  deferred  tax assets,  primarily as it
relates to its net operating  loss  carryforwards.  There was no decrease in the
Company's  valuation  allowance for its deferred tax assets  recorded during the
first quarter of 2002. The income tax benefit recorded for the full year of 2002
with  respect to the  Company's  deferred  tax assets  and the  decrease  in the
valuation  allowance in 2002 approximated  $3.5 million,  or $0.08 per basic and
diluted share, all of which was recorded during the fourth quarter of 2002.

Net  revenues  of $23.0  million  in the  first  quarter  of 2003  increased  by
approximately  $1.8 million from $21.2 million in the first quarter of 2002. The
Company's  net revenue  growth in the 2003  quarter is  attributable  in part to
Microtek's  CleanOp  product  line  which  demonstrated  growth  in excess of 60
percent  in the  first  quarter  of 2003 and an  increase  in OTI's net sales of
approximately  $1.2  million  in the first  quarter  of 2003.  Nuclear  industry
revenues in the first quarter of 2003  approximated  $1.2 million as compared to
$89,000  in the  first  quarter  of 2002 and  contributed  significantly  to the
increase  in  OTI's  net  sales in the  first  quarter  of  2003.  Additionally,



Microtek's  domestic core hospital branded  revenues  increased by approximately
nine  percent  in the first  quarter  of 2003,  and its  international  revenues
continued to demonstrate  impressive growth in excess of 20 percent.  Offsetting
these  increases  were a decline in safety  product  revenues  of  approximately
$381,000 which is attributable  to pricing and other  competitive  pressures,  a
decrease in OEM revenues of approximately  $573,000,  or seven percent,  and the
termination  of deferred  licensing  revenues in December 2002. Net revenues for
the first quarter of 2002  included  $357,000 for the  amortization  of deferred
licensing revenues.

The Company's  gross margin in the first  quarter of 2003 was 38.6  percent,  as
compared  to 40.6  percent  in the  first  quarter  of 2002.  Approximately  one
percentage  point of this  gross  margin  decline  is due to the  absence of the
amortization  of  deferred  licensing  revenues  in the first  quarter  of 2003.
Because  there  was no cost of  sales  associated  with the  deferred  licensing
revenues  recorded  in the first  quarter of 2002,  these  revenues  contributed
directly to the Company's gross margin.  The balance of the gross margin decline
in the first quarter of 2003 stems from the  Company's  changing mix of products
and the slightly dilutive nature of Microtek's CleanOp product line,  Microtek's
international business and OTI's nuclear revenues.

Operating  expenses as a  percentage  of net  revenues  were 32.7 percent in the
first quarter of 2003 versus 33.1 percent in the first quarter of 2002. Selling,
general and  administrative  expenses  were $7.2  million or 31.2 percent of net
revenues in the first  quarter of 2003,  versus $6.7  million or 31.8 percent of
net  revenues  for the  corresponding  prior year  period.  The  increase in the
absolute dollar amount of selling,  general and  administrative  expenses in the
first quarter of 2003 is  attributable  to increases in the  Company's  variable
selling costs,  an increase in marketing  expenses  resulting from the Company's
expanded  marketing  campaign for its branded  products,  and an increase in the
Company's  allowance for doubtful accounts of approximately  $190,000  following
Maxxim Medical, Inc.'s bankruptcy filing in February 2003. The Company increased
its  allowance  for  doubtful  accounts  during  the first  quarter  of 2003 for
potentially  uncollectible Maxxim Medical receivables,  which increased selling,
general  and  administrative  expenses  as  a  percentage  of  net  revenues  by
approximately 1.0 percent.  Absent such charge, the Company's  selling,  general
and  administrative  expenses  as  a  percentage  of  net  revenues  would  have
demonstrated improvement of approximately 1.4 percentage points.

OTI's research and development expenses,  substantially all of which are related
to the nuclear  industry,  decreased by $75,000 in the first  quarter of 2003 as
compared to the first quarter of 2002.  Offsetting this decrease was an increase
in  Microtek's  research  and  development  expenses of  $131,000  related to an
expanded  product  development  program  launched in early 2003 which includes a
number of product enhancements and new product  introductions  planned for 2003.
Amortization of intangibles in first quarter of 2003  approximated  $117,000 and
was consistent with amortization expense recorded in the first quarter of 2002.

Income from operations for the 2003 first quarter was $1.4 million,  versus $1.6
million in the first quarter of 2002. Net cash provided by operating  activities
during the first  quarter of 2003 was $266,000 as compared to net cash  provided
by operating  activities of $884,000 for the first quarter of 2002. The decrease
in operating cash flow is attributable to working capital  investment during the
first quarter of 2003,  due  primarily to the  successful  commercialization  of
OTI's nuclear  business and the resulting  increase in inventories  and accounts
receivable attributable to these operations.

The Company's  balance sheet remains strong with a current ratio (current assets
divided by current  liabilities) of 5.7 to 1 and approximately  $10.3 million in
cash on March 31, 2003. At March 31, 2003,  the Company's  borrowings  under its
revolving  credit  facility  were  $7.3  million  and its  additional  borrowing
availability was approximately $7.0 million.

The Company reiterated its intention to participate in the previously  announced
stock repurchase program, subject to market conditions and restrictions.  During
the  first  quarter  of  2003,  the  Company  spent  approximately  $241,000  to
repurchase  a total of 100,000  shares  under this  program,  bringing the total
number of shares repurchased since the inception of the program to approximately
1.2 million.  The Company's  current  share  repurchase  program,  as amended in
August 2002,  provides for the repurchase of approximately an additional 830,000
shares and extends through December 31, 2003.




Dan R. Lee, the Company's President and Chief Executive Officer,  commented, "We
have added the first quarter of 2003 to our growing list of profitable quarters,
a list that now extends to nine consecutive  quarters. We are proud of our first
quarter  results and the foundation that these results provide for the full year
of 2003.  Of  particular  importance  to us is the first  quarter 2003 growth of
OTI's nuclear  business,  which has exceeded our expectations in terms of timing
and magnitude."

Mr. Lee  continued,  "We are on track to meet our revenue and earnings per share
goals for 2003.  Our  results  for the first  quarter  are  consistent  with our
expectations,   with  the  exception  of  our  recording  earlier  than  we  had
anticipated  the first quarter income tax benefit related to the decrease in the
valuation  allowance  for our deferred  tax assets.  We  determined  that it was
appropriate to record our anticipated income tax benefit for 2003 on a quarterly
basis in  proportion  to our  before-tax  net  earnings,  based on our estimated
effective  tax rate for the  year,  which may  change  subject  to our  expected
performance.  The  benefit  recorded  in the first  quarter of 2003  amounted to
approximately  $0.02 per diluted  share.  In 2002, the entire income tax benefit
for 2002 of approximately $0.08 per share was recorded in the fourth quarter."

Mr. Lee added, "To provide  clarification of our previously  announced  earnings
per share forecast for 2003 in light of the change in timing of the recording of
this income tax benefit,  we currently  forecast our earnings per share to be in
the range of $0.30 to $0.32 per diluted  share,  including  future tax  benefits
which we forecast will be recorded in 2003.  Specifically,  this range  includes
our forecasted income tax benefit for 2003 of $0.13 per diluted share related to
the  forecasted  decrease in our  valuation  allowance  for  deferred tax assets
during  2003.  Except for this  forecasted  income  tax  benefit,  our  earnings
forecast for 2003 is consistent with the forecast that was previously announced.
We continue to expect our 2003 revenues to be approximately $95 million."

Mr. Lee concluded,  "The  management  team of this Company is fully committed to
enhancing  the value of this  Company  to our  shareholders  and to  creating  a
valuable asset that represents the sound,  well-run  profitable company that you
see today."

CONFERENCE  CALL: A conference  call will be conducted by Dan R. Lee,  President
and Chief Executive Officer, and Jerry Wilson, Chief Financial Officer, at 11:00
a.m.  Eastern  Time on May 6,  2003,  and will be  accessible  to the  public by
calling   1-877-792-5693  (U.S.  and  Canada),   Reference:   Microtek  Medical.
International callers dial 1-706-679-4663.  Callers should dial in approximately
10 minutes before the call begins.

To access  the live  broadcast  of the call over the  Internet,  go to  Investor
Relations page at www.MicrotekMed.com.

A conference  call replay will be available at 5:00 p.m.  Eastern Time on May 6,
2003 through 5:00 p.m.  Eastern Time May 12, 2003 and can be accessed by calling
(U.S. and Canada)  1-800-642-1687 or  (international)  1-706-645-9291;  for both
reference conference call ID number: 97126606.

ACTUAL RESULTS COULD DIFFER FROM FORWARD-LOOKING  STATEMENTS: This Press Release
contains forward-looking  statements made pursuant to the safe harbor provisions
of the  Private  Securities  Litigation  Reform  Act of  1995.  Such  statements
include,  but are not  limited  to,  future  repurchases  of  shares  under  the
Company's stock repurchase  program,  the Company's  ability to meet its revenue
and earnings per share goals for 2003,  forecasted  earnings per share for 2003,
the  forecasted  income tax benefit to be recorded  during 2003  relative to the
reduction  in the  Company's  valuation  allowance  for its deferred tax assets,
forecasted  revenues for 2003, and the Company's  ability  enhance the long-term
value of the  Company  for its  shareholders.  Such  statements  are  subject to
certain factors,  risks and uncertainties that may cause actual results,  events
and performance to differ from those referred to in such statements. These risks
include,  without limitation,  those identified in Risk Factors in the Company's
Annual  Report on Form 10-K for the year ended  December  31,  2002,  including,
without  limitation,  the risks  described  in Risk  Factors  under the captions



"-History of Net Losses", "-Reliance upon Microtek",  "-Competition",  "-Product
Liability",   "-Stock  Price   Volatility",   "-Dependence  on  Key  Personnel",
"-Anti-takeover Provisions",  "-Low Barriers to Entry for Competitive Products",
"-Potential  Erosion of Profit  Margins",  "-Risks of Completing  Acquisitions",
"-Small Sales and Marketing Force",  "-Reliance upon  Distributors",  "-Microtek
Regulatory Risks", "-Risks of Obsolescence", "-Reduced OREX Market Potential", "
OREX  Commercialization  Risks", "-OREX Manufacturing and Supply Risks", "-Risks
Affecting Protection of Technology",  "-Risks of Technological Obsolescence" and
"-OTI  Regulatory  Risks".  We do not  undertake  to update our  forward-looking
statements to reflect future events or circumstances.

ABOUT  MICROTEK:  The  Company,  a market  leader  in the  healthcare  industry,
develops,  manufactures  and sells  infection  control  products,  fluid control
products and safety products to healthcare professionals for use in environments
such as operating rooms and outpatient surgical centers.

FOR MORE INFORMATION, PLEASE CALL (800) 476-5973
Dan R. Lee, President & CEO
Jerry Wilson, CFO
Victor P. Thompson, Investor Relations
InvestorRelations@MicrotekMed.com

                                 -TABLES FOLLOW-







                                                 MICROTEK MEDICAL HOLDINGS, INC.
                                                  Unaudited Financial Highlights
                                            (in thousands, except for per share data)

                                                                                  
                                                                            THREE MONTHS ENDED
                                                                                 MARCH 31,
                                                                 ------------------------------------------
                                                                        2003                   2002
                                                                 --------------------   -------------------
Net sales                                                          $          22,986      $         20,824
Licensing revenues                                                                 -                   357
                                                                 --------------------   -------------------
       Net revenues                                                           22,986                21,181
       Gross profit                                                            8,864                 8,596

Operating expenses:
    Selling, general and administrative                                        7,172                 6,744
    Research and development                                                     219                   163
    Amortization of intangibles                                                  117                   114
                                                                 --------------------   -------------------
       Total operating expenses                                                7,508                 7,021
                                                                 --------------------   -------------------

Income from operations                                                         1,356                 1,575

Interest expense, net                                                            (38)                 (158)
Other income, net                                                                 21                     -
Income tax benefit (expense)                                                     858                   (89)
                                                                 --------------------   -------------------
Net income                                                         $           2,197      $          1,328
                                                                 ====================   ===================
Net income per share - basic and diluted                           $            0.05      $           0.03
                                                                 ====================   ===================

Weighted average shares outstanding - basic                                   42,115                42,074
Weighted average shares outstanding - diluted                                 42,775                42,938

BALANCE SHEET DATA:                                                   MARCH 31,            DECEMBER 31,
                                                                        2003                   2002
                                                                 --------------------   -------------------
Cash and cash equivalents                                          $          10,344      $          9,823
Other current assets                                                          43,374                41,757
       Total current assets                                                   53,718                51,580
       Total assets                                                           99,779                96,696
                                                                 ====================   ===================

Current liabilities                                                $           9,400      $          8,630
Long term debt                                                                 7,286                 7,136
Other liabilities                                                              2,039                 2,044
                                                                 --------------------   -------------------
       Total liabilities                                                      18,725                17,810
Shareholders' equity                                                          81,054                78,886
                                                                 --------------------   -------------------
       Total liabilities and shareholders' equity                  $          99,779      $         96,696
                                                                 ====================   ===================