EXHIBIT 99.1

                                                          MICROTEK
                                                          MEDICAL HOLDINGS, INC.
FOR IMMEDIATE RELEASE

                 MICROTEK MEDICAL HOLDINGS ANTICIPATES REPORTING
           FIRST QUARTER 2004 REVENUES OF APPROXIMATELY $28.8 MILLION,
                   AN INCREASE OF 25% OVER PRIOR YEAR QUARTER

            SCHEDULES QUARTERLY EARNINGS RELEASE AND CONFERENCE CALL

COLUMBUS,  MS, April 5, 2004 - Microtek Medical Holdings,  Inc.  (Nasdaq:  MTMD)
announced  today that it expects to report net  revenues  for the quarter  ended
March 31, 2004 of approximately $28.8 million.  The anticipated net revenues for
the first quarter of 2004 represent  increases of approximately $5.8 million, or
25 percent, and approximately $2.3 million, or 9 percent, over the first quarter
of 2003 and the fourth quarter of 2003, respectively.  Included in the Company's
anticipated revenues for the first quarter of 2004 are revenues of approximately
$2.2 million from the Plasco division that was acquired in November 2003.

The Company  reiterated  its guidance  for the full year of 2004 which  includes
revenues  in the range of $115  million to $120  million,  an increase in income
from  operations in 2004 of more than 30 percent over 2003,  and earnings in the
range of $0.19 to $0.22 per diluted share.

The Company has not yet completed its  accounting for the first quarter of 2004.
The Company's  expectations about what it will report for revenues for the first
quarter of 2004 are tentative pending the completion of such accounting.

CONFERENCE CALL
The  Company's  results of  operations  for the quarter ended March 31, 2004 are
scheduled to be released on Monday,  May 10,  2004.  A  conference  call will be
conducted by Dan R. Lee, President and CEO, and Jerry Wilson,  CFO, at 4:30 p.m.
Eastern Time on May 10, 2004,  and will be  accessible  to the public by calling
1-877-407-9210,   Reference:   Microtek  Medical.   International  callers  dial
1-201-689-8049.  Callers should dial in approximately 10 minutes before the call
begins.

To  access  the  live  broadcast  of the  call  over  the  Internet,  log on to:
www.MicrotekMed.com

A conference  call replay will be available  through 11:59 p.m.  Eastern Time on
May 17, 2004 and can be accessed by calling  1-877-660-6853  or  (international)
1-201-612-7415;  for both reference conference call account #1628, Conference ID
#100770.

ACTUAL RESULTS COULD DIFFER FROM FORWARD-LOOKING  STATEMENTS: This Press Release
contains forward-looking  statements made pursuant to the safe harbor provisions
of the Private Securities Litigation Reform Act of 1995. Such statements include
the Company's forecasted revenues, forecasted increase in income from operations
and forecasted  earnings per diluted share for 2004. Such statements are subject
to certain  factors,  risks and  uncertainties  that may cause  actual  results,
events and  performance  to differ from those  referred  to in such  statements.
These risks include, without limitation, those identified in Risk Factors in the
Company's  Annual  Report on Form 10-K for the year  ended  December  31,  2003,
including,  without  limitation,  the risks  described in Risk Factors under the
captions  "-Reliance upon Microtek",  "-History of Net Losses",  "-Competition",
"-Product Liability", "-Stock Price Volatility", "-Dependence on Key Personnel",
"-Anti-takeover Provisions",  "-Low Barriers to Entry for Competitive Products",
"-Potential  Erosion of Profit  Margins",  "-Risks of Completing  Acquisitions",
"-Risks of Successfully Integrating  Acquisitions",  "-Small Sales and Marketing
Force",  "-Reliance  upon  Distributors",   "-Reliance  upon  Large  Customers",
"-Microtek  Regulatory Risks",  "-Risks of Obsolescence",  "-Reduced OREX Market



Potential",  "-OREX  Commercialization  Risks",  "-OREX Manufacturing and Supply
Risks",  "-Risks Affecting  Protection of Technology",  "-Risks of Technological
Obsolescence"  and "-OTI  Regulatory  Risks".  We do not undertake to update our
forward-looking statements to reflect future events or circumstances.

ABOUT  MICROTEK:  The  Company,  a market  leader  in the  healthcare  industry,
develops,  manufactures  and sells  infection  control  products,  fluid control
products and safety products to healthcare professionals for use in environments
such as operating rooms and outpatient surgical centers.

FOR MORE INFORMATION, PLEASE CALL (800) 476-5973
Dan R. Lee, President & CEO
Jerry Wilson, CFO
John Mills, Investor Relations
Investorrelations@microtekmed.com