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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                        --------------------------------

                                    FORM 8-K
                        --------------------------------


                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

        DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): OCTOBER 27, 2004

                             -----------------------

                         MICROTEK MEDICAL HOLDINGS, INC.
             (Exact name of registrant as specified in its charter)
                            -------------------------



                                                                     
                GEORGIA                            0-24866                      58-1746149
                -------                            -------                      ----------
     (State or Other Jurisdiction         (Commission File Number)             (IRS Employer
           of Incorporation)                                                 Identification No.)


                 512 LEHMBERG ROAD, COLUMBUS, MISSISSIPPI 39702
               (Address of principal executive office) (zip code)

       REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE: (662) 327-1863

          -------------------------------------------------------------
          (Former name or former address, if changed since last report)

                            -------------------------

     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_|  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

|_|  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

|_|  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))

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ITEM 1.01  EMPLOYMENT AGREEMENT.

     On October 27, 2004, the Company entered into an Employment  Agreement with
Barbara J. Osborne, Ms. Osborne was appointed to be the Company's Executive Vice
President-Sales   and  Marketing   effective  August  11,  2004.  Ms.  Osborne's
Employment  Agreement specifies a minimum salary and benefits payable during the
term of the Employment  Agreement,  and contains restrictive covenants including
covenants relating to the protection of confidential information and restricting
competition against the Company.  The Employment  Agreement is terminable by the
Company or the employee with or without cause.  In the event of a termination of
the Employment  Agreement by the Company without cause, the employee is entitled
to severance equal to the employee's base salary until the first  anniversary of
the date of such  termination  of  employment,  any  benefits  or  awards  which
pursuant  to the terms of any  compensation  plans  have  been  earned or become
payable (including,  without limitation,  any portion of any bonus for which any
performance  condition,  other than continued employment,  have been satisfied),
but which have not yet been paid, and continued welfare benefits (such as health
insurance)  until  the  first  anniversary  of the date of such  termination  of
employment.  In  the  event  of any  termination  of  Ms.  Osborne's  employment
following  a change  of  control  (as  defined)  of the  Company,  other  than a
termination  as a  result  of death or  disability  or  cause,  the  Company  is
obligated  to pay the  employee a lump sum payment in cash in an amount equal to
the employee's current base salary, any benefits or awards which pursuant to the
terms of any  compensation  plans have been earned or become payable  (including
any  portion  of any  award for which any  performance  conditions,  other  than
continued  employment,  have been  satisfied),  and the Company  shall  continue
welfare benefits (such as health  insurance) until the first  anniversary of the
date of such termination of employment.


ITEM 9.01  FINANCIAL STATEMENTS AND EXHIBITS.

     (a) Financial Statements. N/A

     (b) Pro Forma Financial Information. N/A

     (c) Exhibits.

     Exhibit Number    Description
     --------------    -----------

     10.1              Employment   Agreement  entered  into  on  October   27,
                       2004  by  and between  the Company and Barbara J. Osborne



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                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Company  has  duly  caused  this  report  to be  signed  on  its  behalf  by the
undersigned hereunto duly authorized.

                                        MICROTEK MEDICAL HOLDINGS, INC.



Date:  November 1, 2004                By:  /s/ Dan R. Lee
                                            ------------------------------------
                                            Dan R. Lee, Chairman, President and
                                            Chief Executive Officer


                                        By: /s/ Roger G. Wilson
                                            ------------------------------------
                                            Roger G. Wilson, Chief Financial
                                            Officer




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                                  EXHIBIT INDEX



Exhibit Number        Description
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10.1                  Employment  Agreement  entered  into on October  27, 2004
                      by and between the Company and Barbara J. Osborne




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