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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

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                                    FORM 8-K
                        --------------------------------


                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

        DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): NOVEMBER 3, 2004

                             -----------------------

                         MICROTEK MEDICAL HOLDINGS, INC.
                         -------------------------------
             (Exact name of registrant as specified in its charter)
                            -------------------------



                                                                     
                GEORGIA                            0-24866                      58-1746149
                -------                            -------                      ----------
     (State or Other Jurisdiction         (Commission File Number)             (IRS Employer
           of Incorporation)                                                Identification No.)


                 512 LEHMBERG ROAD, COLUMBUS, MISSISSIPPI 39702
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               (Address of principal executive office) (zip code)

       REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE: (662) 327-1863

          -------------------------------------------------------------
          (Former name or former address, if changed since last report)

                            -------------------------

     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_|  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

|_|  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

|_|  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))

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ITEM 2.02  RESULTS OF OPERATIONS AND FINANCIAL CONDITION.

     On November 3, 2004, Microtek Medical Holdings, Inc. (the "Company") issued
     a press release  reporting its operating results for the quarter and period
     ended September 30, 2004. This press release is attached as Exhibit 99.1 to
     this report and is incorporated herein by reference.


ITEM 9.01  FINANCIAL STATEMENTS AND EXHIBITS.

     (a) Financial Statements.

         N/A

     (b) Pro Forma Financial Information.

         N/A

     (c) Exhibits.

         Exhibit Number    Description
         --------------    -----------

         99.1              Press release dated  November 3, 2004,  reporting the
                           Company's  operating  results  for  the  quarter  and
                           period ended  September 30, 2004



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                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Company  has  duly  caused  this  report  to be  signed  on  its  behalf  by the
undersigned hereunto duly authorized.

                                        MICROTEK MEDICAL HOLDINGS, INC.



Date:  November 3, 2004                 By:  /s/ Dan R. Lee
                                           -------------------------------------
                                           Dan R. Lee, Chairman, President and
                                           Chief Executive Officer


                                        By:  /s/ Roger G. Wilson
                                           -------------------------------------
                                           Roger G. Wilson, Chief Financial
                                           Officer




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                                  EXHIBIT INDEX



Exhibit Number       Description

99.1                 Press release dated  November 3, 2004,  reporting the
                     Company's  operating  results for the quarter and period
                     ended September 30, 2004





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