EXHIBIT 99.1


                                                                  [COMPANY LOGO]

FOR IMMEDIATE RELEASE


             MICROTEK MEDICAL HOLDINGS ANNOUNCES FOURTH QUARTER AND
                                FULL YEAR RESULTS

       FY 2004 NET REVENUES INCREASE 28% OVER PRIOR YEAR TO $126.6 MILLION
      FY 2004 EARNINGS APPROXIMATE $9.9 MILLION, OR $0.22 PER DILUTED SHARE

               RELEASES REVENUE AND EARNINGS FORECASTS FOR FY 2005

ALPHARETTA,  GA, February 25, 2005 - Microtek Medical  Holdings,  Inc.  (Nasdaq:
MTMD), a leading manufacturer and marketer of infection control products,  fluid
control  products  and  safety  products  to  healthcare  professionals,   today
announced results for the fourth quarter and year ended December 31, 2004.

"We are increasingly proud of our performance this year, particularly the growth
in our organic healthcare revenues, our improved operating profitability and the
contributions  from our  recently  acquired  businesses,"  said Dan R. Lee,  the
Company's President and CEO. "Our sales and marketing infrastructure is in place
and is delivering results. Our net revenues increased 28 percent year over year.
Our income from  operations,  excluding the effect of disposition  gains in each
year,  increased 25 percent year over year.  Our cash flow from  operations  for
2004 was  approximately  $12  million,  and we  ended  the  year  with  cash and
equivalents  of $9 million  and  reduced  debt by more than $3  million,  net of
financing our recent acquisitions."

Highlights from the fourth quarter and full year of 2004 include:

     o    Fourth  quarter net revenues  increased 25.2 percent to $33.1 million,
          compared to the fourth quarter of 2003;
     o    Full year 2004 net revenues increased 28.3 percent over 2003 to $126.6
          million;
     o    Organic healthcare revenues grew 5.8 percent in fourth quarter of 2004
          over the prior year quarter and 10.7 percent for the full year;
     o    Net income  for the  fourth  quarter  was $4.3  million,  or $0.10 per
          diluted  share,  including  foreign  currency  exchange  gains of $557
          thousand,  net of income taxes of $293 thousand, and non-cash deferred
          income tax benefits of $1.7 million;
     o    Net  income  for the full  year  2004 was $9.9  million,  or $0.22 per
          diluted share,  including the previously  mentioned  foreign  currency
          exchange gains and non-cash  deferred income tax benefits and gains on
          the sale of certain  property and  equipment  in the third  quarter of
          2004 of $215 thousand.

FOURTH QUARTER AND FULL YEAR RESULTS

Fourth quarter 2004 net revenues were $33.1 million, an increase of $6.7 million
or 25.2  percent  over the fourth  quarter  of 2003.  The  Company's  healthcare
revenues, including revenues attributable to recent acquisitions,  totaled $31.5
million for the fourth  quarter of 2004,  an increase of 24.4  percent  over the
2003  quarter.  For the full year 2004,  net revenues,  including  acquisitions,
increased  by 28.3  percent over 2003 to $126.6  million.  Healthcare  revenues,
including  acquisitions,  increased  27.9 percent  over 2003 to $119.2  million,
compared to $93.1 million in 2003.



Mr. Lee explained, "During the 2004 quarter as compared to the 2003 quarter, the
Company's  domestic  healthcare  revenues  grew 8 percent to $24.1  million as a
result of a 7 percent increase in our domestic branded hospital revenues and a 9
percent increase in our domestic OEM revenues. The Plasco acquisition, continued
growth  in our  CleanOp  product  sales and  increased  sales to  private  label
customers were the primary  contributing  factors to this growth.  The Company's
international  revenues  for the  2004  quarter,  including  revenues  from  the
acquisition of IMP earlier in the year,  demonstrated  an impressive 146 percent
increase to $7.4 million. Excluding IMP revenues, international revenues for the
fourth quarter of 2004 increased by 25 percent."

Mr. Lee continued, "For the full year, domestic healthcare revenues increased by
$16.0 million,  or 20 percent,  as a result of 20 percent  increases in both our
domestic branded and OEM revenues.  Excluding the impact of recent acquisitions,
domestic  healthcare  revenues  increased  by 10 percent.  On the  international
front, full year 2004 revenues increased over 2003 by $10 million or 75 percent,
including $7.9 million in IMP revenues.  Excluding IMP,  international  revenues
posted a 16 percent increase to $15.5 million."

Gross profit for the fourth quarter of 2004 was $13.3  million,  or 40.0 percent
of net revenues,  versus $10.8 million, or 40.9 percent of net revenues, for the
fourth  quarter of 2003. For the full year,  gross profit was $49.6 million,  or
39.2 percent of net  revenues,  compared to $39.2 million or 39.7 percent of net
revenues in 2003.

Selling,  general and administrative ("SG&A") expenses for the fourth quarter of
2004 were $10.5  million,  or 31.7 percent of net revenues,  as compared to $8.7
million,  or 32.8 percent of net revenues in the fourth quarter of 2003. For the
full year  2004,  SG&A  expenses  were  $39.5  million,  or 31.2  percent of net
revenues, versus $31.3 million, or 31.7 percent, of net revenues in 2003.

Income  from  operations  for the  fourth  quarter  and full  year 2004 was $2.2
million and $8.4  million,  respectively,  as  compared  to $1.8  million in the
fourth quarter of 2003 and $7.6 million for the full year 2003.  Excluding gains
on  dispositions of property and equipment in 2004 and 2003 of $215 thousand and
$982 thousand,  respectively,  the Company's income from operations for the full
year 2004 increased by $1.6 million or 25.1 percent over the full year 2003.

Net income for the 2004 fourth  quarter was $4.3  million,  or $0.10 per diluted
share,  including  deferred  income tax  benefits  of $1.7  million  and foreign
currency exchange gains of $557 thousand,  net of income taxes of $293 thousand.
In the fourth  quarter of 2003,  net income,  including $3.9 million in deferred
income tax benefits,  was $5.7 million,  or $0.13 per diluted  share.  Excluding
non-cash deferred income tax benefits and foreign currency exchange gains in the
respective  quarters,  the Company's  net income for the fourth  quarter of 2004
increased by 18.7 percent over the 2003 quarter.

For the full year 2004,  the Company  earned $9.9 million,  or $0.22 per diluted
share,  including  non-cash  deferred  income  tax  benefits  of  $1.7  million,
disposition  gains  of $215  thousand,  and  the  previously  mentioned  foreign
currency  exchange gains. By comparison,  net income for 2003 was $16.0 million,
or $0.37 per diluted  share,  and  included  $8.8  million in non-cash  deferred
income tax benefits and disposition gains of $982 thousand.  Excluding  non-cash
deferred income tax benefits,  disposition  gains and foreign currency  exchange
gains in the respective  years,  net income for 2004 increased 19.7 percent over
2003.

At December 31, 2004,  the  Company's  cash and  investments  approximated  $9.0
million and its  borrowings  under its credit  facility  were $4.5  million,  as
compared to cash and investments of $9.5 million and credit facility  borrowings
of $7.2 million at December 31, 2003.  The Company's  cash flows from  operating
activities in 2004 of approximately $12 million enabled the financing of the IMP
acquisition  and the Company's other capital needs while improving the Company's
net cash position (which is defined as cash and  investments  less the Company's
credit facility borrowings) by $2.2 million.

Mr. Lee concluded,  "Based on our  initiatives for 2005 and excluding the effect
of any possible future acquisitions,  we believe that our revenues for 2005 will
be in the range of $137  million to $142  million,  and we believe our  earnings



will be in the range of $0.23 to $0.25 per diluted  share,  excluding the impact
of any future deferred income tax benefits.  Our forecasted earnings for 2005 of
$0.23 to $0.25 per diluted  share  compares  favorably  to earnings of $0.185 in
2004,  excluding the $1.7 million in deferred income tax benefits.  During 2005,
we are looking for gross margin and operating  income  improvements by improving
our  leverage  through  increasing  our net  revenues,  all of which  equates to
stronger  earnings.  As we  have  mentioned  previously,  we  continue  to  seek
attractive  acquisition  candidates  which  complement  our core  manufacturing,
distribution  and sales and  marketing  competencies.  During  2005,  we hope to
strengthen  Microtek's  position as a leading supplier of high quality infection
control  products to hospitals and outpatient  facilities both  domestically and
abroad."

CONFERENCE  CALL:  The Company  invites its  shareholders  and other  interested
parties  to join its  conference  call which  will be  conducted  by Dan R. Lee,
President  and Chief  Executive  Officer,  and  Jerry  Wilson,  Chief  Financial
Officer,  at  10:00  a.m.  Eastern  Time on  Friday,  February  25,  2005.  This
conference  call will be  accessible  to the  public by  calling  1-877-407-9210
(U.S.), Reference: Microtek Medical.  International callers dial 1-201-689-8049.
Callers  should dial in  approximately  10 minutes  before the call  begins.  To
access  the  live  broadcast  of the  call  over the  Internet,  go to  Investor
Relations page at www.MicrotekMed.com.

A conference  call replay will be available  through 11:59 p.m.  Eastern Time on
March  4,  2005  and  can  be  accessed  by  calling  1-877-660-6853  (U.S.)  or
1-201-612-7415  (international);  for both  reference  conference  call  account
#1628, Conference ID #135956.

ACTUAL RESULTS COULD DIFFER FROM FORWARD-LOOKING  STATEMENTS: This Press Release
contains forward-looking  statements made pursuant to the safe harbor provisions
of the  Private  Securities  Litigation  Reform  Act of  1995.  Such  statements
include,  but  are  not  limited  to,  the  Company's  forecasted  revenues  and
forecasted  earnings for 2005,  the Company's  statement  that it is looking for
gross margin and operating margin improvements by improving its leverage through
increasing its net revenues,  the Company's  ability to consummate  acquisitions
which  complement  the Company's  core  competencies,  and the Company's plan to
strengthen its position as a leading supplier of high quality  infection control
products to hospitals and out-patient  facilities both  domestically and abroad.
Such statements are subject to certain factors, risks and uncertainties that may
cause actual results, events and performance to differ from those referred to in
such statements.  These risks include,  without limitation,  those identified in
Risk  Factors  in the  Company's  Annual  Report on Form 10-K for the year ended
December 31, 2003,  including,  without limitation,  the risks described in Risk
Factors under the captions "-Reliance upon Microtek",  "-History of Net Losses",
"-Competition", "-Product Liability", "-Stock Price Volatility", "-Dependence on
Key  Personnel",  "-Anti-takeover  Provisions",  "-Low  Barriers  to  Entry  for
Competitive  Products",  "-Potential  Erosion  of Profit  Margins",  "-Risks  of
Completing  Acquisitions",  "-Risks of Successfully  Integrating  Acquisitions",
"-Small Sales and Marketing Force",  "-Reliance upon  Distributors",  "-Reliance
Upon Large Customers",  "-Microtek Regulatory Risks",  "-Risks of Obsolescence",
"-Reduced  OREX  Market  Potential",  " OREX  Commercialization  Risks",  "-OREX
Manufacturing and Supply Risks",  "-Risks  Affecting  Protection of Technology",
"-Risks of Technological  Obsolescence"  and "-OTI Regulatory  Risks". We do not
undertake to update our  forward-looking  statements to reflect future events or
circumstances.

ABOUT  MICROTEK:  The  Company,  a market  leader  in the  healthcare  industry,
develops,  manufactures  and sells  infection  control  products,  fluid control
products and safety products to healthcare professionals for use in environments
such as operating rooms and outpatient surgical centers.

FOR MORE INFORMATION, PLEASE CALL (800) 476-5973
Dan R. Lee, President & CEO
Jerry Wilson, CFO
John Mills, Investor Relations
InvestorRelations@MicrotekMed.com
                                -TABLES FOLLOW -








                         MICROTEK MEDICAL HOLDINGS, INC.
                         UNAUDITED FINANCIAL HIGHLIGHTS
                                                                                                    
(In thousands, except for per share data)                 THREE MONTHS ENDED                             YEAR ENDED
                                                              DECEMBER 31                               DECEMBER 31
                                               ------------------------------------------    -----------------------------------
                                                      2004                   2003                 2004               2003
                                               --------------------    ------------------    ---------------    ----------------
Net revenues                                      $         33,143        $       26,462       $    126,581       $      98,664
Gross profit                                                13,260                10,828             49,564              39,216
Operating expenses:
      Selling, general and administrative                   10,505                 8,670             39,483              31,261
      Research and development                                 236                   227              1,048                 940
      Amortization of intangibles                              344                   113                809                 440
                                               --------------------    ------------------    ---------------    ----------------
         Total operating expenses                           11,085                 9,010             41,340              32,641
                                               --------------------    ------------------    ---------------    ----------------
Gain on dispositions                                             -                     -                215                 982
                                               --------------------    ------------------    ---------------    ----------------

Income from operations                                       2,175                 1,818              8,439               7,557
Interest expense, net                                          (71)                  (45)              (265)               (179)
Foreign currency exchange gain                                 850                     -                850                   -
Other income, net                                               25                    56                133                 135
                                               --------------------    ------------------    ---------------    ----------------
      Income before income taxes                             2,979                 1,829              9,157               7,513

Income taxes:
    Current tax expense                                       (348)                  (81)              (926)               (300)
    Deferred tax benefit                                     1,690                 3,930              1,690               8,810
                                               --------------------    ------------------    ---------------    ----------------
           Total income tax benefit (expense)                1,342                 3,849                764               8,510
                                               --------------------    ------------------    ---------------    ----------------

      Net income                                  $          4,321        $        5,678       $      9,921       $      16,023
                                               ====================    ==================    ===============    ================
Net income per share - basic                      $           0.10        $         0.13       $       0.23       $        0.38
                                               ====================    ==================    ===============    ================
Net income per share - diluted                    $           0.10        $         0.13       $       0.22       $        0.37
                                               ====================    ==================    ===============    ================

Weighted average shares outstanding - basic                 43,165                42,490             43,005              42,206
                                               ====================    ==================    ===============    ================
Weighted average shares outstanding - diluted               44,459                44,016             44,500              43,251
                                               ====================    ==================    ===============    ================

BALANCE SHEET DATA:                             DECEMBER 31, 2004      DECEMBER 31, 2003
                                               --------------------    ------------------
Cash and cash equivalents                         $          8,964        $        9,462
Other current assets                                        55,366                54,749
                                               --------------------    ------------------
         Total current assets                               64,330                64,211
         Total assets                                      131,069               118,299
                                               ====================    ==================
Current liabilities                               $         15,511        $       11,691

Long term debt, net of current portion                       4,984                 8,056

Other liabilities                                            1,931                 2,008
                                               --------------------    ------------------
         Total liabilities                                  22,426                21,755
Shareholders' equity                                       108,643                96,544
                                               --------------------    ------------------
         Total liabilities and shareholders'
           equity                                 $        131,069        $      118,299
                                               ====================    ==================