EXHIBIT 10.1

                                                                  Execution Copy


                            NINTH AMENDMENT AGREEMENT


     NINTH  AMENDMENT  AGREEMENT,  dated as of June 30,  2005  (this  "Amendment
Agreement"),  to the Amended and Restated Credit Agreement,  dated as of May 14,
2001, as amended to date (and as the same may be further  amended,  supplemented
or  modified  from  time to time in  accordance  with  its  terms,  the  "Credit
Agreement"),  among Microtek Medical Holdings,  Inc. (formerly known as Isolyser
Company,  Inc.), a Georgia  corporation  ("MMH") and Microtek  Medical,  Inc., a
Delaware  corporation  ("Microtek",  together with MMH,  each a "Borrower"  and,
jointly  and  severally,  the  "Borrowers"),  the  lenders  named  therein  (the
"Lenders"),  the guarantors named therein (the  "Guarantors") and JPMorgan Chase
Bank, N. A. (formerly known as The Chase Manhattan Bank), as agent (the "Agent")
for the Lenders.  Terms used herein and not otherwise  defined herein shall have
the meanings attributed thereto in the Credit Agreement.

     WHEREAS,  the Borrowers  have informed the Agent that they desire to extend
the Revolving Credit Termination Date, modify the pricing of Loans in connection
therewith and modify certain of the applicable financial covenants; and

     WHEREAS,  the Agent and the  Lenders  are  willing  to so modify the Credit
Agreement subject to the terms and conditions of this Amendment Agreement.

     NOW, THEREFORE, for valuable consideration,  the receipt and sufficiency of
which is hereby  acknowledged,  and subject to the fulfillment of the conditions
set forth below, the parties hereto agree as follows:

     SECTION 1. AMENDMENT TO CREDIT AGREEMENT

     1.1 Article I of the Credit  Agreement is hereby  amended in the  following
respects:

     (a) The definition of "Funds from Operations" is hereby deleted.

     (b) The definition of "Eligible Receivables" is hereby amended by adding at
the end thereof the following sentence:

     "Notwithstanding  the foregoing,  all  Receivables  of any single  Customer
     which, in the aggregate,  exceed 15 (or 20, in the case of Cardinal Health)
     % of the Total Eligible  Receivables at the time of any such  determination
     may, in the Administrative Agent's discretion, be deemed not to be Eligible
     Receivables to the extent of such excess."

     (c) The  definition  of  "Final  Maturity  Date" is hereby  amended  in its
entirety to read as follows:

     "'Final Maturity Date' shall mean June 30, 2008."



     (d) The  definition of "Interest  Margin" is hereby amended in its entirety
to read as follows:

          "'Interest  Margin' shall mean, with respect to any Loan or Commitment
     Fee,  the  amount or  percentage,  as  applicable,  as set  forth  below as
     corresponds to the Leverage Ratio set forth below. The Interest Margin will
     be  adjusted,  if  applicable,  following  the  delivery  of the  financial
     statements  to the Agent  required  pursuant to Section  6.05(a) or (b), as
     applicable,   together  with  the  corresponding   compliance  certificates
     required pursuant to Section 6.05(e) and, if the Borrowers believe they are
     entitled  to a lower  Interest  Margin,  a written  request for an Interest
     Margin   adjustment,   commencing   with  the  financial   statements   and
     certificates for the period ending June 30, 2005, or if the Borrowers shall
     fail to  timely  deliver  such  statements  and  certificates  for any such
     period,  then at the highest  Interest  Margin  provided  for herein,  such
     adjustments to be made (i) to a higher Interest  Margin,  at the discretion
     of the Agent, or (ii) to a lower Interest Margin,  within five (5) Business
     Days  after  receipt  of the  Borrowers'  request  for an  Interest  Margin
     adjustment;  provided,  however,  that any adjustment shall not be effected
     with respect to any Eurodollar  Loan until the  continuation  or conversion
     thereof at its expiration:



                                                                                        
                                        Interest Margin for          Interest Margin for         Commitment Fee
           Leverage Ratio                 Eurodollar Loans          Alternate Base Loans            Percentage
           --------------               --------------------        --------------------         ---------------

Less than 1.75:.00                              1.50                        0.25                      0.30%

Equal to or greater than 1.75:1.00              1.75                        0.50                      0.30%
but less than 2.50:1.00

Equal to or greater than 2.50:1.00              2.00                        0.75                      0.375%
but less than 3.25:1.00

Equal to or greater than 3.25:1.00              2.50                        1.25                     0.375%"


     (e) The definition of "Leverage Ratio" is hereby amended in its entirety to
read as follows:

          "'Leverage  Ratio' means,  for  determining  the  applicable  Interest
     Margin with respect to the Borrowers, the ratio of (i) total Funded Debt of
     the  Borrowers  as at each  date of  determination  to (ii)  EBITDA  of the
     Borrowers for the period of four fiscal  quarters most recently ended on or
     prior to each such date of determination."

     (f) A new definition of "EBITDA" is hereby added to read in its entirety as
follows:

          "'EBITDA'  means,  with respect to any person for any period,  (a) the
     sum of (i) Net Income,  (ii) interest expense determined in accordance with
     GAAP,  (iii)  Federal,  state,  local  and  foreign  income  taxes and (iv)


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     depreciation and amortization and other non-cash items properly deducted in
     determining  Net Income in accordance  with GAAP,  minus (b) non-cash items
     properly added in determining Net Income in accordance with GAAP."

     (g) A new  definition of "Fixed Charge  Coverage  Ratio" is hereby added to
read in its entirety as follows"

          "'Fixed Charge  Coverage  Ratio' means,  with respect to the Borrowers
     for  any  period,  the  ratio  of  (i)  EBITDA  less  capital  expenditures
     (including  Capitalized Lease Obligations and Indebtedness secured by Liens
     permitted  under Section  7.01(e) hereof) for such period to (ii) regularly
     scheduled  principal payments of Funded Debt made or to be made during such
     period  plus  dividends  and other  distributions  during  such period plus
     interest expense paid in cash during such period."

     1.2 Section 2.06 of the Credit  Agreement is hereby amended by deleting the
reference in  subsection  (a)(iii)  thereof to "of  three-eights  of one percent
(3/8%)" and  substituting  therefor a reference to "at the  applicable  Interest
Margin."

     1.3 Section 7.07 of the Credit  Agreement is hereby amended in its entirety
to read as follows:

          "Section 7.07.  Capital  Expenditures.  Permit the aggregate amount of
     payments  made  for  capital  expenditures,   including  Capitalized  Lease
     Obligations  and  Indebtedness  secured by Liens  permitted  under  Section
     7.01(e) hereof, to exceed $3,000,000 in any Fiscal Year."

     1.4 Sections 7.08 and 7.09 of the Credit  Agreement  are hereby  deleted in
their entirety.

     1.5 A new Section,  Section 7.18 (Fixed  Charge  Coverage  Ratio) is hereby
added to the Credit Agreement to read in its entirety as follows:

          "Section 7.18.  Fixed Charge Coverage  Ratio.  Permit the Fixed Charge
     Coverage Ratio for the Borrowers and their  Subsidiaries  on a Consolidated
     basis for any four consecutive  fiscal quarter period,  commencing June 30,
     2005, to be less than 1.75:1.00."



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     SECTION 2. CONDITIONS PRECEDENT

     This  Amendment  Agreement  shall become  effective  upon the execution and
delivery of counterparts  hereof by the parties listed below and the fulfillment
of the following conditions:

     (a)  All  representations  and  warranties   contained  in  this  Amendment
Agreement or otherwise made in writing to the Agent in connection herewith shall
be true and correct.

     (b) No unwaived event has occurred and is continuing  which  constitutes an
Event of Default under the Credit Agreement or would constitute such an Event of
Default but for the requirement that notice be given or time elapse or both.

     (c) The  Agent  shall  have  received  an  amendment  fee in the  amount of
$39,500.

     (d) The Agent shall have  received  such other  documents as the Lenders or
the Agent or the Agent's counsel shall reasonably deem necessary.

     SECTION 3. MISCELLANEOUS

     3.1  Each   Borrower  and  each   Guarantor   reaffirms  and  restates  the
representations  and warranties set forth in Article IV of the Credit  Agreement
and all such  representations  and  warranties  shall be true and correct on the
date  hereof  with the same force and effect as if made on such date,  except as
they may specifically refer to an earlier date. Each Borrower and each Guarantor
represents and warrants (which  representations and warranties shall survive the
execution and delivery hereof) to the Agent that:

     (a) it has the corporate power and authority to execute,  deliver and carry
out the terms and  provisions of this Amendment  Agreement and the  transactions
contemplated  hereby and has taken or caused to be taken all necessary corporate
action to authorize the  execution,  delivery and  performance of this Amendment
Agreement and the transactions contemplated hereby;

     (b)  no  consent  of  any  other  person  (including,  without  limitation,
shareholders or creditors of any Borrower or any  Guarantor),  and no action of,
or filing  with any  governmental  or public  body or  authority  is required to
authorize,  or is otherwise required in connection with the execution,  delivery
and performance of this Amendment Agreement;

     (c) this Amendment Agreement has been duly executed and delivered on behalf
of  each  Borrower  and  each  Guarantor  by  a  duly  authorized  officer,  and
constitutes  a legal,  valid and binding  obligation  of each  Borrower and each
Guarantor  enforceable  in  accordance  with its terms,  subject to  bankruptcy,
reorganization,  insolvency,  moratorium  and other  similar laws  affecting the
enforcement  of  creditors'  rights  generally  and  the  exercise  of  judicial
discretion in accordance with general principles of equity;



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     (d) the execution,  delivery and  performance  of this Amendment  Agreement
will not violate any law,  statute or regulation,  or any order or decree of any
court or governmental instrumentality, or conflict with, or result in the breach
of, or constitute a default under any contractual  obligation of any Borrower or
any Guarantor; and

     (e) as of the date hereof (after giving effect to the  consummation  of the
transactions  contemplated  under  this  Amendment  Agreement)  there  exists no
Default or Event of Default.

     By its  signature  below,  each Borrower and each  Guarantor  agree that it
shall  constitute  an Event of Default if any  representation  or warranty  made
above should be false or misleading in any material respect.

     3.2 Each  Borrower  and each  Guarantor  confirms in favor of the Agent and
each Lender that it agrees that it has no defense,  offset, claim,  counterclaim
or recoupment  with respect to any of its  obligations or liabilities  under the
Credit  Agreement or any other Loan  Document  and that nothing  herein shall be
deemed to be a waiver of any  covenant  or  agreement  contained  in the  Credit
Agreement,  and except as herein  expressly  amended,  the Credit  Agreement and
other Loan  Documents  are each ratified and confirmed in all respects and shall
remain in full force and effect in accordance with their respective terms.

     3.3 Upon presentation of its invoice,  the Borrowers  covenant and agree to
pay in full all legal fees charged, and all costs and expenses incurred, by Kaye
Scholer  LLP,  counsel  to  the  Agent,  in  connection  with  the  transactions
contemplated  under this Agreement and the other Loan Documents and  instruments
in connection herewith and therewith.

     3.4 All references to the Credit  Agreement and the other Loan Documents in
the Credit Agreement, the Loan Documents and the other documents and instruments
delivered  pursuant to or in connection  therewith shall mean such agreements as
amended hereby and as each may in the future be amended, restated,  supplemented
or modified from time to time.

     3.5  This  Amendment  Agreement  may  be  executed  by the  parties  hereto
individually or in combination, in one or more counterparts, each of which shall
be an original  and all of which shall  constitute  one and the same  agreement.
Delivery of an executed  counterpart of a signature page by telecopier  shall be
effective as delivery of a manually executed counterpart.

     3.6 THIS  AMENDMENT  AGREEMENT  SHALL BE  GOVERNED  BY, AND  CONSTRUED  AND
INTERPRETED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF NEW YORK.



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     3.7 The parties  hereto shall,  at any time and from time to time following
the execution of this Amendment Agreement,  execute and deliver all such further
instruments  and take all such further action as may be reasonably  necessary or
appropriate in order to carry out the provisions of this Amendment Agreement.

                                   MICROTEK MEDICAL HOLDINGS, INC. (f/k/a
                                   ISOLYSER COMPANY, INC.)


                                   By:______________________________
                                            Name:
                                            Title:


                                   MICROTEK MEDICAL, INC.


                                   By:______________________________
                                            Name:
                                            Title:


                                   JPMORGAN CHASE BANK, N. A. (f/k/a THE
                                   CHASE MANHATTAN BANK), as Agent and as Lender


                                   By:______________________________
                                            Name:
                                            Title:






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