FIRST MODIFICATION OF
                    THIRD AMENDED AND RESTATED LOAN AGREEMENT


     THIS  MODIFICATION  is made and  entered  into as of the 14th day of April,
1997, by and between CRYOLIFE,  INC., a Florida  corporation  ("Borrower"),  and
NATIONSBANK, N.A. (SOUTH), a national banking association which is the successor
by merger to Bank South, formerly known as Bank South, N.A. ("Lender").

                               STATEMENT OF FACTS

     Borrower  and  Lender are  parties to a Third  Amended  and  Restated  Loan
Agreement, dated as of August 30, 1996 (the "Loan Agreement").

     Borrower  and  Lender  desire to amend the Loan  Agreement  as  hereinafter
provided.

     NOW,  THEREFORE,  for and in  consideration  of the premises and the mutual
agreements,  warranties  and  representations  herein made, as well as $10.00 in
hand  paid by each  party  hereto to the  other,  and  other  good and  valuable
consideration,  the  receipt  and  sufficiency  which are  hereby  acknowledged,
Borrower  and Lender  agree that all  capitalized  terms  used  herein  (and not
otherwise  defined  herein)  shall  have  the  meanings  given  them in the Loan
Agreement as herein amended and Borrower and Lender further agree as follows:

                               STATEMENT OF TERMS

     1. The Loan  Agreement  is hereby  amended  by  adding  the  following  new
definitions to Section 101 thereof:

        "Subordinated  Debt" means any and all  Indebtedness of Borrower that is
     expressly  subordinated in right of payment to the Loans, including without
     limitation the Subordinated Debenture.

        "Subordinated Debenture" means the Subordinated Convertible Debenture of
     Borrower,  dated March 5, 1997, issued to J. Clayton Pruitt,  Sr., M.D., in
     the principal  face amount of  $4,999,999,  and any  extensions,  renewals,
     modifications or substitutions thereof or therefor.

     2. The Loan Agreement is hereby further amended by adding a new Section 509
thereto, immediately following Section 508 thereof:

        Section 509.  Subordinated  Debt.  None of the Credit Parties shall make
     any payment of any part or all of any Subordinated Debt







     in violation of the subordination  agreement  relating to such Subordinated
     Debt or voluntarily prepay any Subordinated Debt (provided that, so long as
     no Default or Event of Default shall then exist or would be caused thereby,
     Borrower  may prepay the  Subordinated  Debenture  in  accordance  with its
     terms);  or enter into any agreement  (oral or written)  which could in any
     way be  construed  to amend,  modify,  alter or  terminate  any one or more
     instruments or agreements, evidencing or relating to any Subordinated Debt.

     3. The Loan Agreement is hereby further  amended by deleting  Schedules 301
and 508  originally  attached to the Loan  Agreement  and  substituting  in lieu
thereof the Schedules 301 and 508 attached hereto.

     4. The effectiveness of this Modification is subject to:

        (a) the prior or concurrent receipt by Lender of this Modification, duly
            executed by Borrower;

        (b) the prior or  concurrent  receipt  by  Lender  of all  documentation
            required to be delivered  under Section 202(c) of the Loan Agreement
            in connection with the acquisition of Ideas for Medicine, Inc.;

        (c) any and all  guarantors  of the Loans  shall have  consented  to the
            execution,  delivery and performance of this Modification and all of
            the  transactions   contemplated  hereby  by  signing  one  or  more
            counterparts of this Modification in the appropriate space indicated
            below and returning same to Lender; and

        (d) the  truth and  accuracy  in all  material  respects  of  Borrower's
            representations and warranties in Section 6 below.

     5. Except as expressly  modified herein, the Loan Agreement shall remain in
full force and effect. Nothing contained herein shall be deemed to be or operate
as a novation  or an accord and  satisfaction  of the Loan  Agreement  or of any
indebtedness arising thereunder.

     6.  Borrower  hereby  represents  and  warrants  to  Lender  that  (a) this
Modification and the  supplemental  Financing  Documents  executed in connection
herewith  have been duly  authorized,  executed and  delivered by Borrower,  (b)
after  giving  effect to this  Modification,  no Default or Event of Default has
occurred and is  continuing  as of this date and (c) all of the  representations
and  warranties  made by Borrower in the Loan  Agreement are true and correct in
all material respects on and as of the date of this Modification  (except to the
extent  that any such  representations  or  warranties  expressly  referred to a
specific  prior  date).  Any  breach  by  Borrower  of its  representations  and
warranties  contained  in this  Section  shall be an Event  of  Default  for all
purposes of the Loan Agreement.








     7. This Modification shall be governed and construed in accordance with the
laws of the State of Georgia and this Modification shall inure to the benefit of
and shall be binding upon the parties hereto and their respective successors and
permitted assigns.

     8. This  Modification  may be executed in  multiple  counterparts,  each of
which  shall be deemed to be an  original  and all of which when taken  together
shall constitute one and the same instrument.

     IN WITNESS WHEREOF, Lender has executed this Modification, and Borrower has
executed  this  Modification  and placed its seal hereon,  all as of the day and
year first above set forth.

                                            LENDER:

                                            NATIONSBANK, N.A. (SOUTH)


                                            By:_________________________________
                                               Assistant Vice President


                                            BORROWER:

                                            CRYOLIFE, INC.


                                            By:_________________________________
                                               Title:___________________________

                                                    (CORPORATE SEAL)








                                  SCHEDULE 301
                                  ------------ 
                                  SUBSIDIARIES


CryoLife International, Inc.
Ideas for Medicine, Inc. (formerly known as CryoLife Acquisition Corporation)







                                  SCHEDULE 508
                                  ------------ 
                              PERMITTED FUNDED DEBT

1.   Indebtedness incurred by Borrower in connection with its acquisition of all
     or substantially all of the assets of United  Cryopreservation  Foundation,
     Inc., not to exceed $1,250,000.

2.   Indebtedness evidenced by the Subordinated Debenture.

3.   Indebtedness  arising  in  connection  with the  purchase  of  the bio-glue
     technology,  in the amount of  $445,816  (the  "Kowanko Note").








462873.1