March 31, 1998 VIA EDGAR - --------- Securities and Exchange Commission 450 Fifth Street, N.W. Washington, D.C. 20549 Re: OXiGENE, Inc. - Form 12b-25, Notification of Late Filing of Form 10-K for the period ended December 31, 1997 ----------------------------------------------------------------- Ladies and Gentlemen: On behalf of OXiGENE, Inc. (the "Company"), we hereby file Form 12b-25 in order to extend the time for filing of the Company's Annual Report on Form 10-K for the period ended December 31, 1997. Simultaneously with this filing, we also are sending a copy of this Form 12b-25 to The Nasdaq Stock Market, Inc. Please telephone the undersigned at (212) 504-6804 if you have any questions or comments. Very truly yours, /s/ M. Andica Kunst -------------------------- M. Andica Kunst cc: OXiGENE, Inc. The Nasdaq Stock Market, Inc.