March 31, 1998



VIA EDGAR
- ---------

Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549


          Re:  OXiGENE, Inc. - Form 12b-25,  Notification of Late Filing of Form
               10-K for the period ended December 31, 1997
               -----------------------------------------------------------------

Ladies and Gentlemen:

     On behalf of OXiGENE,  Inc. (the "Company"),  we hereby file Form 12b-25 in
order to extend the time for filing of the Company's  Annual Report on Form 10-K
for the period ended December 31, 1997.

     Simultaneously  with this  filing,  we also are sending a copy of this Form
12b-25 to The Nasdaq Stock Market, Inc.

     Please  telephone  the  undersigned  at  (212)  504-6804  if you  have  any
questions or comments.

                                                      Very truly yours,


                                                        /s/ M. Andica Kunst
                                                      --------------------------
                                                      M. Andica Kunst


cc:      OXiGENE, Inc.
         The Nasdaq Stock Market, Inc.