EXHIBIT 10.3

                             CONSULTING AGREEMENT


      THIS IS A CONSULTING  AGREEMENT  ("Agreement") made and entered into as of
the 1st day of May,  1999,  by and  between  DIANON  Systems,  Inc.,  a Delaware
corporation ("DIANON"), and A. Bruce Shapiro ("Shapiro").

                                  RECITALS:

      WHEREAS,  DIANON has acquired substantially all of the assets and business
of Kyto  Meridien  Diagnostics,  L.L.C.,  a New York limited  liability  company
("Kyto Meridien"), pursuant to the terms of an Asset Purchase Agreement dated as
of April 7, 1999, by and among DIANON,  Kyto Meridien,  Kyto Diagnostics,  L.P.,
Meridien Diagnostics Labs, Inc., Shapiro and Ralph M.
Richart, M.D. (the "Asset Purchase Agreement"); and

      WHEREAS,  DIANON desires to retain  Shapiro for a period  commencing as of
the Closing Date  ("Closing  Date") of the Asset  Purchase  Agreement and ending
three years from that date and  Shapiro  desires to be so retained by DIANON for
such period on the terms and conditions hereinafter provided; and

      WHEREAS, Shapiro's position with Kyto Meridien has given him access to and
familiarity  with the  confidential  information  and business of Kyto  Meridien
acquired by DIANON and his consultation  with DIANON will give him access to and
familiarity with the confidential information and business of DIANON; and

      WHEREAS, DIANON would be irreparably harmed if Shapiro should disclose any
of the confidential  information  which Shapiro has acquired and will acquire or
by entering  into any  activity  competing  with DIANON or the  business of Kyto
Meridien acquired by DIANON.

      NOW,  THEREFORE,  in  consideration  of the  mutual  covenants,  terms and
conditions of this Agreement, Shapiro and DIANON agree as follows:

      1.    CONSULTATION.  DIANON hereby  retains the services of Shapiro to aid
in the transition (including, without limitation, assuring the timely payment of
accounts  payable and current  liabilities  retained by Sellers under Subsection
2(e) of the Asset  Purchase  Agreement)  and  stabilization  and to  advise  and
consult with respect to the growth of the business  acquired by DIANON  pursuant
to the Asset  Purchase  Agreement  and to advise and consult in such other areas
within his experience, knowledge and expertise. Such services shall be performed
by Shapiro in person at DIANON's  facility in  Woodbury  New York,  or, with his
consent,  at  its  headquarters  in  Connecticut.  Shapiro  shall  make  himself
available to DIANON for the  performance  of such services no more than two days
per week  forty-eight  weeks per year as  requested  by DIANON  during  the term
hereof.  In providing  such  consulting  services,  Shapiro  shall in good faith
render advice and provide  information to DIANON,  fully reflecting the range of
his knowledge,  information and experience in the areas of consultation.  During
the term of this  Agreement,  Shapiro  shall at all times  conduct  himself  and
perform his services in a proficient and professional manner, in accordance with
the applicable standards of care and the highest standards of ethics.




      2.   COMPENSATION.   As full  consideration  for the services  rendered by
Shapiro  pursuant  to  this  Agreement,  together  with  Shapiro's  undertakings
pertaining to the  preservation of confidential  information and the restrictive
covenant  set forth,  respectively,  in  Sections 4 and 5 below,  DIANON  shall,
during the term of this Agreement, compensate Shapiro as follows:

            (a)  _DIANON shall render  monthly  payments of nineteen  thousand
three hundred and nineteen ($19,319) dollars to Shapiro.;

            (b)   DIANON  shall  reimburse the reasonable  business  expenses of
Shapiro in  performing  his duties  hereunder in  accordance  with such policies
regarding expenses as DIANON may have in effect from time to time;

            (c)   At no cost to Shapiro,  DIANON shall, for a period of at least
six  months  from and after the  Closing  Date,  make  available  for the use of
Shapiro his current office  located at 40 Crossways Park Drive in Woodbury,  New
York; provided that DIANON may terminate such rights effective at any time after
such six month period by the provision of three month's prior written notice.

      3.    TERM.   Unless sooner terminated in accordance with Section 9 below,
the term of this  Agreement  shall  commence  on the  Closing  Date of the Asset
Purchase Agreement and end on the third anniversary thereof.

      4.    CONFIDENTIAL  INFORMATION.  From and after the date hereof,  Shapiro
will not,  directly  or  indirectly,  use for his own  benefit or  purposes,  or
disclose  to, or use for the  benefit or  purpose of any person or entity  other
than DIANON,  any  confidential  information,  knowledge or data relating to the
business or operations of DIANON or those acquired by DIANON from Kyto Meridien.
Such information,  knowledge or data includes,  but is not limited to, secret or
confidential  matters not published or generally known in the industry,  such as
information regarding pricing, costs, purchasing,  profits, financing,  markets,
sales  or  customer  lists,   future   developments,   audits,   investigations,
enforcement actions, regulatory compliance,  laboratory procedures and marketing
and expansion  plans.  Any and all materials which may be produced or created by
Shapiro or others,  or which may come into his  possession  in the course of his
employment,  or which  relate  in any  manner  to the  business  or  prospective
business of DIANON are and shall be the exclusive property of DIANON and Shapiro
shall  not have  any  right,  title or  interest  in any  such  materials.  Upon
termination  of his  employment,  Shapiro shall not have the right to remove any
such materials  from the offices of DIANON and shall  promptly  return to DIANON
all things of whatever nature that belong to DIANON, including all materials and
records in any form,  format or medium containing or related to the confidential
information  of DIANON,  and he shall  neither  make nor retain any part or copy
thereof for his personal use or the use of third parties.

            Notwithstanding  the foregoing,  confidential  information shall not
include any information  that is: (i)  demonstrably  developed  independently by
Shapiro;  (ii)  publicly  disclosed by DIANON or otherwise in the public  domain
without violation of this Agreement by Shapiro;  or (iii) rightfully received by
Shapiro from a third party, which, by disclosing to Shapiro, does not breach any
obligation or duty to DIANON.  Notwithstanding  this Section 4, Shapiro may make
such  disclosures  of  confidential  information  as are duly compelled by court
order or as required by law.


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      5.    RESTRICTIVE  COVENANT.  In  consideration  of this Agreement and the
purchase of the assets and business of Kyto Meridien by DIANON,  for a period of
three  years  from and  after the  Closing  Date and for any  renewal  period or
extension of the term hereof,  and  notwithstanding  any earlier  termination of
this Agreement, except upon the express written consent of DIANON (which consent
may be unreasonably withheld), Shapiro shall not, for his own account, on behalf
of, or jointly with,  any other person,  directly or  indirectly,  own,  manage,
operate,  join,  control,  finance,  invest in, perform services for, advise (or
advise  others with respect to), or  otherwise  participate  in, or be connected
with,  or  become  or act as a  partner,  manager,  member,  director,  officer,
employee,  consultant,  representative  or agent  of any  business  (other  than
DIANON), individual,  partnership, firm, proprietorship,  professional practice,
corporation,  limited  liability  company or other entity that provides clinical
laboratory or anatomic or surgical  pathology  services within a one hundred and
fifty mile radius of New York City; provided however,  that Shapiro may purchase
or own,  solely as an inactive  investor,  the  securities of any entity that is
publicly  traded on a national  securities  exchange where  Shapiro's  aggregate
holdings of such  securities do not exceed two percent of the voting power or of
any class of stock of such entity.

      In addition to the foregoing,  during the same  three-year  period and for
any renewal  period or extension of the term hereof,  Shapiro  shall not, on his
own  behalf,  or on behalf  of any  other  person or  entity:  (i)  solicit  the
customers,  suppliers  or  employees of DIANON or any  affiliated  entity;  (ii)
solicit or seek to hire any  employee  of DIANON or any  affiliated  entity;  or
(iii) attempt in any manner,  directly or  indirectly,  to influence,  induce or
encourage any such employee to leave the  employment of DIANON or any affiliated
entity.  Shapiro shall not take any action intended,  or which may reasonably be
expected,  directly or  indirectly,  to impair the goodwill,  reputation or good
name of DIANON or Kyto Meridien, or otherwise to be detrimental to the interests
of DIANON,  including any action intended,  or which may reasonably be expected,
directly or indirectly, to benefit a competitor of DIANON.

      6.    SCOPE  OF  RESTRICTIONS.  Shapiro agrees that the  restrictions  set
forth in Section 5 are  reasonable.  If,  however,  a court  determines that any
provision of Section 5 is unreasonable,  either in geographic  scope,  length of
time or  otherwise,  then  Section 5 shall be  interpreted  and  enforced to the
maximum extent  permitted by law and Shapiro consents and agrees that such scope
may be judicially modified accordingly in any proceeding brought to enforce such
restriction.

      7.    INJUNCTIVE  RELIEF. Shapiro acknowledges that irreparable harm would
be suffered by DIANON in the event that any of the provisions of Sections 4 or 5
were not performed fully in accordance with the terms specified therein and that
monetary  damages are an  inadequate  remedy for breach  thereof  because of the
difficulty of  ascertaining  and  quantifying  the amount of damage that will be
suffered  by DIANON in the event  that such  undertakings  and  provisions  were
breached or violated. Accordingly,  Shapiro agrees that DIANON shall be entitled
to an  injunction or  injunctions  to restrain,  enjoin and prevent  breaches or
threatened  breaches of the  covenants,  undertakings  and  provisions  of those
sections and to enforce  specifically the provisions therein in any court of the
United  States  or any  state  having  jurisdiction  over the  matter,  it being
understood  that any such remedies  shall be in addition to, and not in lieu of,
any other  rights and  remedies  available  at law or in equity and shall not be
deemed  exclusive of any common law or other rights of DIANON in connection with
the matters covered hereby.


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      8.    INTELLECTUAL  PROPERTY RIGHTS.  Shapiro agrees to assign, and hereby
does  assign to  DIANON,  all of his  right,  title and  interest  in and to all
inventions, improvements, discoveries and technical developments, whether or not
patentable,  which he solely or jointly with others,  may  conceive,  develop or
reduce to practice  during the term of this  Agreement,  which are  related,  in
whole or in part,  directly or  indirectly,  to the  business of, or services or
products of the type, provided by DIANON, or which may reasonably be provided or
used by  DIANON,  or which  are  otherwise  developed,  in whole or in part,  at
DIANON's expense.

      Shapiro shall disclose promptly to DIANON's Chief Executive  Officer,  all
such  ideas,   discoveries  and  improvements  conceived  by  him  alone  or  in
collaboration with others, and shall cooperate fully with DIANON both during and
after the term of this Agreement, with respect to the procurement of patents for
the  establishment  and  maintenance  of DIANON's  rights and  interests in said
inventions, improvements, discoveries or developments, and shall sign all papers
which DIANON may  reasonably  deem  necessary  or  desirable  for the purpose of
vesting it with such rights.

      9.    TERMINATION.      (a)  This  Agreement   shall  terminate  on  the
occurrence of any of the following events:

            (i)   Upon the death of Shapiro;

            (ii)  Upon  the sending of written notice from DIANON describing the
activities  constituting an act of default falling within any one or more of the
following categories:

                  (A) Shapiro's  breach of any material promise or agreement set
                  forth herein, including,  without limitation,  those set forth
                  in  Sections  4, 5 and 8  above,  or his  failure  to  provide
                  substantially  all  of the  services  reasonably  required  by
                  Section 1; or

                  (B)  Shapiro's  commission  of an act of gross  negligence  or
                  willful  misconduct,  or acts showing a pattern of negligence,
                  in the performance of his services or obligations hereunder or
                  otherwise injurious to DIANON;

Provided  that no such  termination  under  this  subsection  9(a)(ii)  shall be
effective  unless  Shapiro has first been afforded an opportunity to correct the
alleged  default,  but such default  continues,  recurs or can not  otherwise be
corrected,  in the good faith  judgment  of  DIANON,  within  thirty  days after
delivery of such written notice of default to Shapiro;

            (iii) Upon  the  occurrence of an event or the  commission of an act
under  which  Shapiro  is or may  become  subject  to  mandatory  or  permissive
exclusion  from  Medicare and State health care  programs,  including  those set
forth  in  sections  1128,  1156  and 1892 of the  Social  security  Act and any
regulations promulgated thereunder; and

            (iv)  Upon  the passage of thirty (30) days after written  notice of
termination without cause from DIANON to Shapiro.


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      (b)   In  the  event  of a  termination  of  this  Agreement  pursuant  to
subsections  9(a)(i)  or  9(a)(iv)  above,  DIANON  shall  continue  to pay  the
compensation set forth in Section 2(a) above until the third  anniversary of the
Closing Date of the Asset Purchase Agreement.

      (c)   Sections  4, 5, 6, 7, 12 and 14 of this Agreement shall survive,  in
accordance with their terms,  any  termination of this  Agreement,  whether such
termination  be with or without cause.  No  termination of this Agreement  shall
relieve  Shapiro of his  obligations  to DIANON with respect to the  restrictive
covenant in Section 5 and the  preservation  of confidential  information  under
Section 4. Should Shapiro violate any of the  requirements of Sections 4 or 5 of
this Agreement, DIANON may, in addition to any other remedies provided to DIANON
under this  Agreement,  at law or in equity,  immediately  terminate any further
post-termination  payments to Shapiro  hereunder  that  otherwise  may have been
required.

      10.   INDEPENDENT  CONTRACTOR.   Shapiro's  services  hereunder  shall  be
rendered in the capacity of an independent  contractor of DIANON, and Shapiro is
not in any respect or circumstances  an employee of DIANON.  Neither Shapiro nor
DIANON has the authority to enter into contracts or assume any  obligations  for
or on behalf of the other or to make any warranties or representations for or on
behalf of the other.  Shapiro shall be solely  responsible for any taxes imposed
on the  performance  of  his  consulting  services  or  the  payment  therefore,
including  withholding  of state and federal  income or estimated  tax payments,
sales or ad valorem taxes,  unemployment  compensation,  worker's  compensation,
obligations under the Federal Insurance  Contributions Act, Federal Unemployment
Tax Act and other taxes,  costs and expenses  incurred in the performance of his
engagement  hereunder,   except  as  expressly  assumed  by  DIANON  under  this
Agreement. Shapiro expressly indemnifies and holds DIANON harmless from any such
liabilities.

      11.   WAIVER.  The  failure  of  either  party  at  any  time  to  require
performance  by the other party of any provision  hereof shall not affect in any
way the full right to require such performance at any time thereafter, nor shall
a waiver by either party of a breach of any provision hereof be taken or held to
be a waiver of the provision itself.

      12.   NOTICES.  All notices,  requests,  demands and other  communications
hereunder  shall be in  writing  and shall be deemed to have been duly  given if
delivered by hand, by  nationally  recognized  overnight  delivery  service,  or
mailed by  certified or  registered  mail,  postage  prepaid,  and  addressed as
follows:

            If to Shapiro:    A. Bruce Shapiro
                              40 Juneau Boulevard
                              Woodbury, New York 11797


            If to DIANON:     DIANON Systems, Inc.
                              200 Watson Boulevard
                              Stratford, Connecticut  06497
                              Attn: President

      13.   ENTIRE  AGREEMENT.  This Agreement and the Asset Purchase  Agreement
set forth the entire agreement and  understanding of the parties  concerning the
subject  matter  hereof.  


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This  Agreement  may be  amended  only by a  written  instrument  signed by both
parties, which instrument must make specific reference to this Agreement and the
intention to modify it.

      14.   GOVERNING  LAW. This Agreement shall be governed by and construed in
accordance  with the laws of the  State of New  York  without  reference  to the
conflicts of laws provisions of that state.


      IN WITNESS WHEREOF, the parties have executed this Agreement as of the day
first above written.


                                          /s/ A. Bruce Shapiro
                                          --------------------
                                          A. Bruce Shapiro


                                          DIANON SYSTEMS, INC.

                                          /s/ Kevin C. Johnson
                                          --------------------
                                          By: Kevin C. Johnson
                                          Its:  President & CEO




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