Exhibit 2.1



                           PURCHASE AND SALE AGREEMENT


                            dated as of June 22, 1998

                                  by and among

                               GENZYME CORPORATION

                      RESEARCH AND DIAGNOSTIC SYSTEMS, INC.

                                       and

                               TECHNE CORPORATION





                                                      
                                TABLE OF CONTENTS

                           PURCHASE AND SALE AGREEMENT
                                                                          Page

1.    THE ACQUISITION.......................................................1
   1.1   Director Approval..................................................1
   1.2   Transfer of Assets.................................................2
   1.3   Consideration for Transfer.........................................4
   1.4   The Closing........................................................4
   1.5   Assumption of Liabilities..........................................5
   1.6   Allocation of Purchase Price.......................................5
   1.7   Sales, Transfer and Use Taxes......................................5
   1.8   Instruments of Conveyance and Transfer.............................6
   1.9   Physical Transfer of the Assets....................................6
   1.10  Schedules..........................................................6
   1.11  Definitions........................................................6
2.    REPRESENTATIONS AND WARRANTIES OF GENZYME.............................6
   2.1   Organization, Authority, Approval and Enforceability...............7
   2.2   Title to Assets....................................................7
   2.3   Schedules Complete.................................................8
   2.4   Condition of Assets................................................8
   2.5   Equipment and Inventory............................................8
   2.6   No Product Liability Claims........................................8
   2.7   Customers..........................................................8
   2.8   Products...........................................................8
   2.9   Warranty Policies..................................................8
   2.10  No Violation of Agreements.........................................8
   2.11  Taxes..............................................................9
   2.12  Insurance..........................................................9
   2.13  Compliance with Applicable Law.....................................9
   2.14  Financial Information..............................................9
   2.15  No Material Adverse Change.........................................9
   2.16  Product Recalls....................................................9
   2.17  Litigation........................................................10
   2.18  No Brokers........................................................10
   2.19  Warranty..........................................................10
   2.20  Disclosure........................................................10
3.    REPRESENTATIONS AND WARRANTIES OF R&D AND TECHNE.....................10
   3.1   Organization and Standing.........................................10
   3.2   Authority, Approval and Enforceability............................11
   3.3   Capitalization....................................................12
   3.4   No Violation of Agreements........................................12
   3.5   Techne Commission Filings; Financial Statements...................12
   3.6   Conduct of Business in the Ordinary Course; Absence of 
         Certain Changes and Events........................................13



   3.7   Litigation........................................................14
   3.8   Governmental and Other Consents...................................14
   3.9   Offering..........................................................14
   3.11  Subsidiaries......................................................15
   3.12  Tax Matters.......................................................15
   3.13  Insurance.........................................................15
   3.14  Environmental and Safety Laws.....................................15
   3.15  No Brokers........................................................15
4.    COVENANTS OF GENZYME PRIOR TO CLOSING DATE...........................15
   4.1   Access and Investigation..........................................15
   4.2   Operation of the Business.........................................16
   4.3   Negative Covenant.................................................16
   4.4   Required Approvals................................................16
   4.5   Notification......................................................16
   4.6   No Negotiation....................................................17
   4.7   Best Efforts......................................................17
5.    COVENANTS OF TECHNE AND R&D..........................................17
   5.1   Approvals of Governmental Bodies..................................17
   5.2   Access and Investigation..........................................17
   5.3   Notification......................................................17
   5.4   No Negotiation....................................................18
   5.5   Best Efforts......................................................18
6.    CONDITIONS PRECEDENT TO OBLIGATIONS OF TECHNE AND R&D................18
   6.1   Conveyance and Assignment.........................................18
   6.2   Consents..........................................................18
   6.3   Accuracy of Representations and Warranties........................18
   6.4   Performance of Agreements.........................................19
   6.5   Actions or Proceedings............................................19
   6.6   Stockholder's Rights Agreement....................................19
   6.7   No Adverse Change.................................................19
   6.8   Court Orders......................................................19
   6.9   Opinion of Counsel for Genzyme....................................19
   6.10  Additional Documents..............................................19
   6.11  HSR Act...........................................................19
   6.12  Minimum Average Market Price......................................19
7.    CONDITIONS PRECEDENT TO OBLIGATIONS OF GENZYME.......................20
   7.1   Purchase Price....................................................20
   7.2   Accuracy of Representations and Warranties........................20
   7.3   Performance of Agreements.........................................20
   7.4   Actions or Proceedings............................................20
   7.5   Opinion of Counsel for R&D and Techne.............................20
   7.6   Stockholder's Rights Agreement....................................20
   7.7   No Adverse Change.................................................20
   7.8   Court Orders......................................................21
   7.9   HSR Act...........................................................21



8.    ROYALTIES............................................................21
   8.1   Royalty Payment...................................................21
   8.2   Manner of Payment.................................................21
   8.3   Audit and Inspection Rights.......................................21
9.    MANUFACTURING TECHNICAL ASSISTANCE BY GENZYME........................22
10.   TRANSITION SALES AND MANUFACTURING OBLIGATION........................22
   10.1  Sales of Inventory................................................22
   10.2  Products and Pricing..............................................22
   10.3  Sales Support.....................................................23
   10.4  Warranty..........................................................23
   10.5  Force Majeure.....................................................23
11.   NONUSE AND NONDISCLOSURE.............................................24
   11.1  Protection of Confidential Information............................24
   11.2  Nonuse............................................................24
   11.3  Exceptions........................................................25
   11.4  Partial Disclosures...............................................25
   11.5  Disclosure to R&D and Techne Employees............................25
   11.6  Disclosure to Genzyme Employees...................................26
12.   INTELLECTUAL PROPERTY INDEMNITY, LIABILITIES AND LIMITATIONS.........26
   12.1  Genzyme Intellectual Property Disclaimer..........................26
   12.2  Infringement Indemnity by R&D.....................................26
   12.3  Infringement Indemnity by Genzyme.................................26
   12.4  Discovering and Reporting Infringements...........................26
   12.5  No Trademark Rights...............................................26
13.   TRADEMARK LICENSE....................................................27
   13.1  Grant of License..................................................27
   13.2  Quality Control...................................................27
   13.3  Term of License...................................................27
   13.4  Termination of License............................................28
   13.5  Additional Trademark..............................................28
14.   INDEMNIFICATION......................................................28
   14.1  Indemnification by Genzyme........................................28
   14.2  Indemnification by R&D and Techne.................................29
15.   ADDITIONAL AGREEMENTS................................................30
   15.1  Incorporation of Schedules and Exhibits...........................30
   15.2  Governmental Documents and Financial Information..................30
   15.3  Cooperation.......................................................31
   15.4  Contract Assignment...............................................31
   15.5  Assistance with Audits............................................31
   15.6  Maintenance of Records............................................31
   15.7  Product Claims and Returns........................................31
   15.8  Adjustments.......................................................32
   15.9  Taxes.............................................................32
   15.10 Cooperation in Litigation.........................................32
   15.11 Discount on Sales of R&D Products to Genzyme......................32



16.   MISCELLANEOUS........................................................33
   16.1  Expenses..........................................................33
   16.2  Public Announcements..............................................33
   16.3  Term and Termination..............................................33
   16.4  Entire Agreement; Modifications; Waiver...........................34
   16.5  Survival of Representations and Warranties........................35
   16.6  Further Assurances................................................35
   16.7  Captions..........................................................35
   16.8  Counterparts......................................................35
   16.9  Successors and Assigns............................................35
   16.10 Parties in Interest...............................................35
   16.11 Notices...........................................................36
   16.12 Law Governing.....................................................37






                             EXHIBITS AND SCHEDULES


Schedule 1.2(b)        Inventory

Schedule 1.2(c)(A)     Technology

Schedule 1.2(c)(B)     Technology Rights Retained

Schedule 1.2(d)        Customer, Supplier and Other Mailing Lists

Schedule 1.2(e)        Trademarks and Trademark Applications

Schedule 1.2(f)        Dealer and Distributor Agreements

Schedule 1.2(g)        800 Phone Numbers

Schedule 1.2(i)        Agreements with Vendors

Schedule 1.2(j)        Standard Cost of Genzyme Products

Schedule 1.2(k)        Licenses

Schedule 1.2(l)        Marketing Studies and Plans

Schedule 1.2(o)        Products in Development

Schedule 1.2(p)        Equipment

Schedule 1.2(q)        Open Purchase Orders

Schedule 1.2(r)        Websites

Schedule 1.4           Closing Agenda

Schedule 1.5A          Assumed Liabilities

Schedule 1.5B          Additional Assumed Liabilities

Schedule 1.9           Schedule for Transfer

Schedule 1.11          Definitions

Schedule 2.2A          Liens



Schedule 2.2B          Continuing Liens

Schedule 2.6           Product Liability Claims and Threats

Schedule 2.8           Product List

Schedule 2.9           Warranty Policies

Schedule 2.14          Financial Information

Schedule 2.15          Material Adverse Changes

Schedule 2.16          Product Recalls

Schedule 2.19          Product Specifications

Schedule 3.3           Techne Capitalization

Schedule 3.7           Techne Litigation

Exhibit 6.6            Stockholder's Rights Agreement

Exhibit 6.9            Opinion of Counsel for Genzyme

Exhibit 7.5            Opinion of Counsel for Techne and R&D

Section 8.1            Royalty

Exhibit 11.5           R&D's Confidentiality Agreement

Exhibit 11.6           Genzyme's Confidentiality Agreement

Schedule 13.1          Licensed Trademarks

Schedule 13.5          Territory for Extended Trademark License








                           PURCHASE AND SALE AGREEMENT


     PURCHASE  AND SALE  AGREEMENT  ("Agreement")  dated  this 22nd day of June,
1998, by and among Genzyme Corporation,  a Massachusetts  corporation having its
principal  place of  business at One Kendall  Square,  Cambridge,  Massachusetts
02139  ("Genzyme"),   Research  and  Diagnostic   Systems,   Inc.,  a  Minnesota
corporation  having its  principal  place of  business  at 614  McKinley  Place,
Minneapolis,  Minnesota  55413-2610 ("R&D") and Techne Corporation,  a Minnesota
corporation  and the sole  stockholder  of R&D  having  its  principal  place of
business at 614 McKinley Place, Minneapolis, Minnesota 55413-2610 ("Techne").

                                    RECITALS

     WHEREAS,  Genzyme, through its Diagnostics business unit, is engaged in the
business of developing,  manufacturing  and selling a line of cytokines,  growth
factors,  antibodies,  proteins, cytokine and apoptosis ELISA systems, and other
research  products  used  in  the  areas  of  immunology  and  cellular  biology
(collectively, the "Business");

     WHEREAS,  the  parties  intend  that R&D shall  purchase  from  Genzyme and
Genzyme shall sell to R&D, certain  specified  tangible and intangible assets of
that portion of the business of Genzyme that principally relates to the Business
on the  terms  and  subject  to the  conditions  more  fully  set  forth in this
Agreement (the "Acquisition");

     WHEREAS,  Genzyme  desires to grant to R&D certain  rights with  respect to
certain intellectual  property and proprietary materials related to the Business
(the "Technology Rights"; the Acquisition and the grant of the Technology Rights
are sometimes referred to collectively herein as the "Transaction");

     WHEREAS, a portion of the consideration for the Acquisition will consist of
shares of Common Stock of Techne and Techne is  covenanting to register the sale
of such shares to the public; and

     WHEREAS,  Genzyme,  Techne and R&D desire to make certain  representations,
warranties and agreements in connection  with the Acquisition and also desire to
prescribe various conditions precedent to the Acquisition.

     NOW, THEREFORE,  in consideration of the promises and the mutual agreements
contained herein,  the parties hereto,  intending to be legally bound, do hereby
agree as follows:

1.   THE ACQUISITION

     1.1 Director  Approval.  The respective  Boards of Directors of R&D, Techne
and Genzyme have duly approved the  execution and delivery of this  Agreement in
accordance  with  the  applicable  provisions  of  the  Massachusetts   Business
Corporation Law ("MBCL") and the Minnesota Business Corporation Act ("MBCA"), as
applicable, and their respective charter documents.



     1.2 Transfer of Assets.  Subject to the terms and  conditions  set forth in
this Agreement,  at the Closing  (defined below) Genzyme will, or will cause its
subsidiaries to, sell,  convey,  transfer,  assign,  and deliver to R&D, and R&D
will  purchase  from  Genzyme the  following  assets and  properties  of Genzyme
principally relating to the Business, wherever located (collectively referred to
in this Agreement as the "Assets"):

     (a)  the goodwill pertaining to the Business;

     (b)  all inventories  associated  with the  Business of the types listed on
Schedule  1.2(b) in the possession or control of Genzyme or its  subsidiaries at
the  time  of   Closing   including:   finished   goods,   raw   materials   and
work-in-progress;  packaging materials (vials,  caps, labels,  plates,  cartons,
boxes  and  inserts);   marketing  and  promotional  materials,   including  all
literature, catalogs, posters, and videotapes (including all copyright therein);
promotional gifts; and exhibit booths (the "Inventory");

     (c)  technology owned or licensed by Genzyme  associated  with the Business
listed on Schedule 1.2(c)(A)  (collectively,  the "Technology"),  which Schedule
includes:

          (i)  to  the  extent  transferable,  clones  (including  nucleic  acid
     constructs); cell lines (including bacterial, eukaryotic, hybridoma, yeast,
     and nucleic acid host cell lines and expression hosts);  vectors (including
     vector  systems and vector  constructs);  cDNA  libraries and other nucleic
     acid  libraries;  nucleic  acid  primers,  probes and  markers;  expression
     systems; nucleic acid sequence information; gene mapping information; serum
     pools;  genetically engineered or antibody-producing  animals; and title to
     any such materials which are deposited with any third party,  including any
     deposits made with the ATCC or other internationally recognized depository;

          (ii)  Good   Manufacturing   Practice,   manufacturing   and   Quality
     Assurance/Quality  Control  protocols and  procedures,  including  Standard
     Operating  Procedures and test results,  including the  specifications  for
     each product included in the Inventory (the  "Specifications  for Products"
     or "Specifications");

          (iii)  product  development  histories  including   documentation  and
     validation data; and

          (iv) all know-how,  proprietary  techniques and any other confidential
     information  reasonably  necessary to enable a reasonably skilled scientist
     to carry on the current  commercial  activities  of the Business or to make
     meaningful  use of the technology  referred to in section  1.2(c)(i)-(iii),



     including  copies  of  laboratory  notebooks,   computer  files  and  other
     documents or portions thereof reflecting such information;

provided  that Genzyme  shall retain  rights in a portion of the  Technology  as
described in Schedule 1.2(c)(B);

     (d)  customer, supplier and other mailing lists listed on Schedule 1.2(d);

     (e)  registered  and  unregistered  trademarks  and  trademark applications
listed on Schedule 1.2(e);

     (f)  to  the  extent  transferable,  Genzyme's  rights under the dealer and
distributor agreements listed on Schedule 1.2(g);

     (g)  800  phone  number(s) for Order  Entry, Customer Service and Technical
Services listed on Schedule 1.2(g);

     (h)  copies of sales  history  data  by customer, by product and by country
for  past  3 years,  including product standard cost (manufactured) and purchase
price (bought in) information  for each  product,  and  sales  volume  histories
by customer; provided, however, if any of such  data is  unavailable,  then  the
parties shall reasonably agree to the provision of alternative data;

     (i)  to  the extent  transferable,  Genzyme's  rights under the  agreements
with   vendors  listed  on  Schedule  1.2(i)  and  information  on  purchases of
bought-in product;

     (j)  copies of  accounting information  on  products  to be acquired by R&D
including:  product  costing/standard costs, purchase price variances,  bills of
material,  etc.;  provided,  however, if any of such information is unavailable,
then  the  parties  shall  reasonably  agree  to the  provision  of  alternative
information;

     (k)  to  the  extent  transferable or sublicensable, Genzyme's rights under
the license and sublicense agreements listed on Schedule 1.2(k),  which includes
licenses to all software  currently  used by Genzyme in conducting the Business,
other than licenses to third-party, non-custom software;

     (l)  copies of marketing studies and/or plans listed on Schedule 1.2(l);

     (m)  copies of current fiscal year sales projections;

     (n)  copies of   commission/compensation   data  on  such Genzyme sales and
marketing  personnel  who  would  be potentially  employed by R&D, as reasonably
requested by R&D;



     (o)  research  products  in  development  listed on Schedule 1.2(o) and all
pre-release validation data relating to such products;

     (p)  equipment  listed  on  Schedule  1.2(p)  and, to the extent reasonably
available,  information  on  its  location,  date  acquired,  acquisition costs,
depreciation and current book value;

     (q)  Genzyme's rights under  the  open  purchase  orders and/or commitments
to purchase  materials,  components,  inventories, packaging materials listed on
Schedule 1.2(q); and

     (r)  to the extent transferable or  sublicensable, information  relating to
the  Business  contained  in  the  web site(s)/links  listed on Schedule 1.2(r),
including all copyright therein.

     Notwithstanding  the foregoing,  Genzyme will not sell,  convey,  transfer,
assign or deliver to R&D any Assets of Genzyme  S.R.L.,  which business  Genzyme
will continue to operate following the Closing.

     1.3 Consideration for Transfer. Subject to the terms and conditions of this
Agreement,  at the  Closing,  R&D and Techne,  as the case may be, shall pay the
consideration  ("Purchase  Price") to Genzyme for the transfer of the Assets and
the grant of the Technology Rights, consisting of:

     (a)  $24,760,000  in cash by wire transfer in same day funds at the time of
Closing pursuant to instructions of Genzyme;

     (b)  such number of shares of Common  Stock of Techne as is  determined  by
dividing  the Average  Market  Price into  $17,000,000,  subject to the right of
Techne to limit the number of shares which it issues to one million and, in lieu
of issuing any shares in excess of one million,  to pay an additional  amount by
wire transfer equal to the difference between the aggregate Average Market Price
of one million  shares and  $17,000,000  (the  shares so issued are  referred to
herein as the "Shares"); and

     (c)  a royalty payable by R&D to Genzyme in  accordance  with  Section 8 of
this Agreement.

     1.4  The Closing.

     (a)  The Closing shall be held at the principal  offices of Techne at 10:00
a.m. CDT on July 1, 1998, or such other place,  time and date as R&D and Genzyme
may mutually select (the "Closing").

     (b) At the Closing, in addition to any and all other documents specifically
required by this Agreement to be delivered, the parties shall have delivered the
documents specified on the Closing Agenda contained in Schedule 1.4.



     1.5 Assumption of Liabilities. Subject to and upon the terms and conditions
herein set forth,  R&D shall  assume and become  liable for,  from and after the
Closing,   the   following   liabilities   of  Genzyme   and  its   subsidiaries
(collectively, the "Assumed Liabilities") and no other liabilities:

     (a)  the liabilities of Genzyme or its subsidiaries  incurred in connection
with the  Business  specifically  listed in  Schedule  1.5A,  to the extent such
liabilities have not been paid or discharged before the Closing;

     (b)  all liabilities and obligations of Genzyme and its subsidiaries  under
the contracts, agreements, commitments, undertakings and promises of Genzyme and
its subsidiaries specifically transferred or assigned to R&D pursuant to Section
1.2 and/or set forth in Schedule 1.5B to the extent accruing (or, in the case of
obligations,  required by the  applicable  contract to be  performed)  after the
Closing;  provided  however,  that R&D shall not assume or become liable for any
such  liabilities  or  obligations  to the  extent  arising  from any  breach of
contract,  breach of warranty,  tort, infringement or violation of law occurring
before the  Closing  or to the  extent  arising  out of any  charge,  complaint,
action, suit,  proceeding,  hearing,  investigation,  claim or demand based upon
acts, sales of product, events or conduct occurring before the Closing; and

     (c)  all  liabilities and  obligations of Genzyme and its subsidiaries  not
incurred in the Ordinary Course of Business  during the period  beginning on the
date hereof and ending upon the  Closing,  as mutually  agreed in writing by the
parties.

Other than R&D's liability for the Assumed  Liabilities,  neither R&D nor Techne
shall have liability or responsibility for any liability of Genzyme.

     1.6 Allocation of Purchase Price. The consideration  paid by R&D to Genzyme
for the transfer of the Assets, as determined  pursuant to Section 1.3, shall be
allocated by R&D and Genzyme to the Assets in accordance  with the provisions of
Section  1060  of the  Internal  Revenue  Code  of  1986,  as  amended,  and the
regulations thereunder.  R&D and Genzyme agree that the fair market value of the
Assets for federal, state and other tax purposes will be the value of the Assets
as determined by the following procedure: (a) within 90 days of the Closing, R&D
shall deliver to Genzyme two copies of an agreement in the form attached  hereto
as Exhibit 1.6 executed by R&D setting forth the fair market value of the Assets
with a completed  Internal Revenue Service Form 8594 entitled "Asset Acquisition
Statement under Section 1060" attached; and (b) Genzyme shall consent in writing
to such fair market  values of the Assets,  such consent not to be  unreasonably
withheld,  by executing a copy of such  agreement and returning it to R&D within
ten business days.  Notwithstanding  the foregoing,  Techne agrees that the fair
market value of the foreign  Assets  transferred  shall be equal to the net book
value  of  such  Assets.  The  value  of  intangibles  will be  determined  by a
post-Closing appraisal.

     1.7 Sales,  Transfer and Use Taxes.  R&D shall pay all sales,  transfer and
use taxes  arising out of the  transfer of the Assets and shall  assume all cost
and expense for  import/export  licenses  and  customs  duties  pursuant to such
transfer of Assets.



     1.8  Instruments  of Conveyance  and Transfer.  On the date of the Closing,
subject to the terms and conditions of this Agreement, (a) Genzyme hereby agrees
that it  shall  deliver  or  cause to be  delivered  to R&D or R&D's  authorized
designee all of the following (the "Conveyance Documents"):  such bills of sale,
assignments,   consents  or  requests  for  consents,   endorsements  and  other
recordable  instruments  of  assignment,  transfer and  conveyance,  in form and
substance reasonably  satisfactory to R&D and its counsel, as shall be effective
to vest in R&D all of the  right,  title and  interest  of Genzyme in and to the
Assets, free and clear of all liens,  charges,  easements,  mortgages,  pledges,
claims of ownership,  security interests, levies, attachments,  restrictions and
other encumbrances in favor of any third party (collectively referred to in this
Agreement as a "Lien")  other than the Assumed  Liabilities,  and (b) R&D hereby
agrees that it shall  execute and deliver such  agreements  assuming the Assumed
Liabilities  in form and substance  reasonably  satisfactory  to Genzyme and its
counsel.

     1.9 Physical Transfer of the Assets. R&D and Techne agree that the physical
transfer  of the Assets  shall occur in  accordance  with  Schedule  1.9 hereto.
Within 5  business  days of both the date of  Closing  and the date of  physical
transfer of the Inventory to R&D in accordance  with Schedule 1.9,  Genzyme will
provide R&D a report containing costed,  detailed  perpetual  Inventory listings
for raw materials,  work-in-process and finished goods as of the date of Closing
and the date of physical transfer of the Inventory, as the case may be.

     1.10  Schedules.  Schedules  attached to this  Agreement  at the time it is
executed shall be complete with the exception of Schedule  1.2(d),  which at the
time of execution  will be summary in nature and will not identify  customers or
persons on mailing lists by name,  and Schedules  1.2(b) and 1.2(q),  which will
reflect the Inventory and open purchase  orders and/or other  commitments  as of
the date  hereof.  At the  Closing,  the  initial  version  of  Schedule  1.2(d)
containing  summary  information  will be replaced by a revised  Schedule 1.2(d)
containing specific,  complete,  detailed information,  and Schedules 1.2(b) and
1.2(q) will be updated as of the date of Closing.  The final  Schedules  will be
initialed by Genzyme and R&D.

     1.11 Definitions.  Certain capitalized terms used in this Agreement and not
otherwise  defined herein shall have the  definitions  specified in the attached
Schedule 1.11.

2.   REPRESENTATIONS AND WARRANTIES OF GENZYME

     Subject to the  qualification  that  representations  and  warranties as to
particular  Schedules are limited at the time of execution of this  Agreement by
the summary nature of required information  permitted by Section 1.10 until such
Schedules are replaced prior to the Closing,  Genzyme represents and warrants to
Techne and R&D that:

     2.1 Organization, Authority, Approval and Enforceability.

     (a) Genzyme is a corporation  duly organized,  validly existing and in good
standing under the laws of the Commonwealth of Massachusetts,  has all requisite
corporate power and authority to own, operate and lease its properties and carry



on its business as now conducted, and is duly qualified to do business and is in
good standing as a foreign corporation in each jurisdiction in which the failure
to so qualify could have a Material Adverse Effect.

     (b) Genzyme has full corporate power and authority to execute,  deliver and
perform its obligations under this Agreement, the Stockholder's Rights Agreement
and all documents to be executed by Genzyme in connection with the  transactions
contemplated  hereby and thereby and all corporate  action of Genzyme  necessary
for such execution, delivery and performance has been duly taken.

     (c) No approval of this Agreement,  the  Stockholder's  Rights Agreement or
the transactions  contemplated hereby or thereby is required by the stockholders
of Genzyme under the Articles of Organization or Bylaws of Genzyme, the MBCL, or
otherwise.

     (d) This Agreement, the Stockholder's Rights Agreement and all documents to
be executed by Genzyme in connection with the transactions  contemplated  hereby
and thereby each is, and upon due execution and delivery by the parties  thereto
will be, a legal, valid and binding obligation of Genzyme,  enforceable  against
Genzyme in accordance with its respective terms, subject, as to enforcement,  to
bankruptcy,  insolvency,  reorganization and other laws of general applicability
relating to or affecting creditors rights and to general equity principles.

     (e) The  execution  and  delivery  by  Genzyme  of this  Agreement  and the
Stockholder's Rights Agreement,  and the execution and delivery of all documents
to be  executed  by Genzyme in  connection  with the  transactions  contemplated
hereby and thereby do not, and the  performance  and  consummation by Genzyme of
the  transactions  contemplated by this Agreement and the  Stockholder's  Rights
Agreement  will not,  result in any  conflict  with,  breach or  violation of or
default,  termination,  forfeiture  or lien  under (or upon the  failure to give
notice or the lapse of time,  or both,  result in any conflict  with,  breach or
violation  of or default,  termination,  forfeiture  or lien under) any terms or
provisions of the Articles of Organization or Bylaws of Genzyme,  as amended, or
any  statute,  rule,  regulation,  judicial  or  governmental  decree,  order or
judgment  to which  Genzyme is a party or to which it or its assets are  subject
that has or is likely to have a Material Adverse Effect.

     2.2 Title to Assets.  Genzyme has good and marketable  title to the Assets,
free and clear of any and all Liens except as set forth in Schedule  2.2A.  Upon
delivery by Genzyme to R&D of the Assets at Closing and pursuant to the terms of
this Agreement,  R&D will acquire good and marketable title to the Assets,  free
and clear of any and all Liens except as set forth on Schedule 2.2.B.

     2.3 Schedules  Complete.  The assets and  properties  listed in the various
Schedules to Section 1.2 of this Agreement  constitute  all material  assets and
properties used by Genzyme in its conduct of the Business as of the date of this
Agreement.

     2.4  Condition  of  Assets.  All  Assets  are and shall be in  satisfactory
operating  condition and free from any material defects,  except for normal wear
and tear.



     2.5 Equipment and Inventory.

     (a) All  items of  tangible  personal  property,  including  equipment  and
supplies  included in the Assets and  currently  used by Genzyme in the Business
are in good operating condition, normal wear and tear excepted, and are adequate
and suitable for the purposes for which they are presently being used;

     (b) Schedule 1.2(b) is a substantially  correct and complete list as of the
date  of  this   Agreement  of  all  material   inventories  of  raw  materials,
work-in-process,  parts,  supplies and finished products included in the Assets,
identified by category and location; and

     (c) Except as specifically  requested by R&D in writing pursuant to Section
10 of this  Agreement,  the  Inventory  has been and will be through the date of
Closing  maintained at levels  consistent with the practices of Genzyme prior to
April 1,  1998 and at  levels  sufficient  to meet  the  reasonably  anticipated
purchase orders of its customers  subject to normal  scheduling of manufacturing
of items produced by Genzyme and of purchasing items manufactured by others.

     2.6 No Product Liability  Claims.  Except as identified in Schedule 2.6, no
product  liability claims or claims of intellectual  property  infringement have
been asserted or, to Genzyme's  knowledge,  overtly  threatened  against Genzyme
with respect to the Business.

     2.7 Customers.  Schedule 1.2(d) includes a complete and current schedule of
all the Business' customers.

     2.8 Products.  A list of all of the products  currently  sold and available
from Genzyme in connection with the Business is set forth in Schedule 2.8.

     2.9 Warranty Policies. Schedule 2.9 sets forth all of the product warranty,
repair and replacement policies and obligations of the Business.

     2.10 No Violation of Agreements. Neither the execution and delivery of this
Agreement nor the  consummation of the  transactions  contemplated  hereunder by
Genzyme  will  violate or conflict  with any  agreement,  contract,  note,  debt
instrument, security agreement or mortgage, or any other commitment binding upon
Genzyme that has or is likely to have a Material Adverse Effect.

     2.11 Taxes. Genzyme has accurately prepared and timely filed all income tax
returns  and other tax  returns  required  to be  filed,  and has paid,  or made
provision  for the  payment  of,  all taxes  which  have or may have  become due
pursuant to said returns or pursuant to any  assessment  which has been received
by it,  and with  respect  to which the  failure  to  prepare,  file pay or make
provision for would result in a lien on any of the Assets.

     2.12 Insurance.  The policies of product liability insurance in effect with
respect  to the  Business  are,  through  the  date  of this  Agreement,  valid,
outstanding  and  enforceable   policies.   Genzyme  has  consistently   carried
$1,000,000 or more of product liability  insurance coverage without lapse, which
coverage shall apply to all products sold through the Business  through the date
of Closing.



     2.13 Compliance with Applicable Law. With respect to the Business,  Genzyme
has duly  complied in respect of products,  operations,  machinery and equipment
and all other property,  practices and aspects of the Business, and the Business
and the Assets  transferred  hereunder to R&D comply with all  applicable  Laws,
orders,  ordinances,  judgments  and  decrees  of all  governmental  authorities
(foreign,  federal, state, local or otherwise) where the failure to comply would
have a Material Adverse Effect.

     2.14  Financial  Information.  Attached as Schedule 2.14 are: (a) unaudited
statements of revenues,  cost of sales,  gross profit and direct expenses of the
Business for the years ended December 31, 1995, 1996 and 1997; and (b) unaudited
statements of revenues,  cost of sales,  gross profit and direct expenses of the
Business  for the six months  ended June 30, 1996 and 1997 and the three  months
ended March 31, 1998 (such financial  information being collectively referred to
as the "Financial Information").  Since December 31, 1997, Genzyme has conducted
the Business and kept  records for the Business in a consistent  manner  without
material change of policy or procedure.

     2.15 No Material  Adverse  Change.  Except as set forth in  Schedule  2.15,
since  June 30,  1997,  there has not been any  Material  Adverse  Change in the
business,  operations,   properties,  prospects,  assets  or  condition  of  the
Business,  and no event has occurred or circumstance  exists that can reasonably
be foreseen to result in such a Material Adverse Change.

     2.16 Product Recalls. Except as set forth in Schedule 2.16, Genzyme has not
experienced any seizure, recall or market withdrawal of any product with respect
to the  Business  nor has it been  requested  to  conduct  a  recall  or  market
withdrawal  with respect to the Business by any  governmental  agency within the
last five (5) years.  There is no action or proceeding,  pending or, to the best
of Genzyme's knowledge,  threatened,  by any governmental agency against Genzyme
of which  Genzyme is aware  relating to the safety of any of Genzyme's  products
related to the Business.

     2.17  Litigation.  Except as disclosed in Schedule  2.17, no action,  suit,
proceeding  or  investigation  is pending or, to the best  knowledge of Genzyme,
threatened  against Genzyme nor, to the best knowledge of Genzyme,  is there any
basis therefor,  which action, suit, proceeding and investigation  questions the
validity of this  Agreement  or the right of Genzyme to enter into it or to take
any action in connection with it, or which can reasonably be foreseen to result,
either individually or in the aggregate, in a Material Adverse Effect.

     2.18 No Brokers. Genzyme has not entered into any agreement that could give
rise to any  liability on the part of Techne or R&D for  brokerage,  finder's or
agent's fees or commissions in connection with this Agreement or any transaction
contemplated hereby.

     2.19 Warranty. Genzyme warrants that the inventory of finished goods listed
on Schedule 1.2(b) will be in accordance with the Specifications for Products as



set forth in Schedule 2.19 attached hereto.  In the event that an inventory item
does not conform with its Specifications for Products,  upon written notice from
R&D specifying such non-conformity,  and as confirmed by Genzyme,  Genzyme shall
at its  own  cost  without  unreasonable  delay  deliver  new  product  for  the
replacement of the defective  quantity or R&D shall be credited against the next
Royalty payment due pursuant to Section 8 the cost of the defective item,  based
on the standard cost  therefor  identified in Schedule  1.2(j).  Upon  Genzyme's
direction,  R&D shall either return such defective quantity at Genzyme's cost or
destroy it. Genzyme's  obligations  under the second and third sentences of this
Section 2.19 shall terminate, in the case of finished goods, upon the expiration
date  of  such  goods  on  a  product-by-product  basis,  and  in  the  case  of
work-in-process and raw materials, six months from the date of Closing.

     2.20 Disclosure. No representation or warranty of Genzyme contained in this
Agreement  contains any untrue statement of a material fact and, when taken as a
whole,  such  statements do not omit to state a material fact necessary in order
to make the statements therein not misleading.

3.  REPRESENTATIONS AND WARRANTIES OF R&D AND TECHNE

     R&D and Techne jointly and severally represent and warrant to Genzyme that:

     3.1 Organization and Standing.

     (a)  Each  of R&D and  Techne  is a  corporation  duly  organized,  validly
existing and in good standing under the laws of the State of Minnesota,  has all
requisite corporate power and authority to own, operate and lease its properties
and carry on its business as now conducted, and is duly qualified to do business
and is in good standing as a foreign  corporation in each  jurisdiction in which
the failure to so qualify could have a Material Adverse Effect.

     (b) Each of R&D and Techne has  delivered to Genzyme  complete and accurate
copies of its Articles of Incorporation and Bylaws, each as amended to date.

     3.2 Authority, Approval and Enforceability.

     (a) Each of R&D and  Techne  has full  corporate  power  and  authority  to
execute,   deliver  and  perform  its  obligations  under  this  Agreement,  the
Stockholder's  Rights  Agreement  and  all  documents  to be  executed  by it in
connection with the transactions  contemplated hereby and thereby,  and to issue
the  Shares,  and all  corporate  action of R&D and  Techne  necessary  for such
execution, delivery, performance and issuance has been duly taken.

     (b) No approval of this Agreement or the Stockholder's  Rights Agreement or
the transactions  contemplated hereby or thereby is required by the stockholders
of R&D or Techne,  under their  respective  Articles of Incorporation or Bylaws,
the MBCA or otherwise.

     (c) The execution  and delivery by R&D and Techne of this  Agreement and by
Techne of the Stockholder's Rights Agreement,  and the issuance by Techne of the



Shares and the  execution  and  delivery of all  documents to be executed by R&D
and/or  Techne in  connection  with the  transactions  contemplated  hereby  and
thereby do not, and the  performance  and  consummation by R&D and Techne of the
transactions  contemplated  by  this  Agreement  and  the  Stockholder's  Rights
Agreement  will not,  result in any  conflict  with,  breach or  violation of or
default,  termination,  forfeiture  or lien  under (or upon the  failure to give
notice or the lapse of time,  or both,  result in any conflict  with,  breach or
violation  of or default,  termination,  forfeiture  or lien under) any terms or
provisions of the Articles of  Incorporation  or Bylaws of either R&D or Techne,
or any statute,  rule,  regulation,  judicial or governmental  decree,  order or
judgment,  agreement, lease or other instrument to which either R&D or Techne is
a party or to which it or its assets are subject that has or is likely to have a
Material Adverse Effect.

     (d) This Agreement, the Stockholder's Rights Agreement and all documents to
be  executed  by  R&D  and/or  Techne  in  connection   with  the   transactions
contemplated  hereby and thereby each is, and upon due execution and delivery by
the  parties  thereto  will be, a legal,  valid and  binding  obligation  of the
executing  party,  whether  R&D or  Techne  or  both,  enforceable  against  the
executing  party,  whether  R&D or  Techne or both,  in  accordance  with  their
respective  terms,  subject,  as  to  enforcement,  to  bankruptcy,  insolvency,
reorganization and other laws of general applicability  relating to or affecting
creditors rights and to general equity principles.

     (e)  All  corporate  action  on the  part  of  Techne,  its  directors  and
stockholders  necessary  for the issuance of the Shares and the  performance  of
Techne's obligations under this Agreement and under any other agreement referred
to herein  has been  taken.  The  Shares,  when  issued in  compliance  with the
provisions of this Agreement,  will be validly issued and will be fully paid and
nonassessable and will be free of any liens or encumbrances;  provided, however,
that the Shares are  subject to  restrictions  on transfer  under  state  and/or
federal  securities  laws. The issuances by Techne of the Shares are not subject
to any  preemptive  rights or rights of first refusal which have not been waived
or terminated prior to the Closing.

     3.3 Capitalization.

     (a) The authorized capital stock of Techne consists of 50,000,000 shares of
Common Stock (the "Common Stock") and 5,000,000  shares of undesignated  capital
stock,  none of which are issued and  outstanding.  Schedule  3.3 sets forth the
number of shares of Common Stock of Techne issued and outstanding as of the date
of this  Agreement.  All such  issued  and  outstanding  shares  have  been duly
authorized and validly issued and are fully paid and nonassessable.

     (b) Options  representing in the aggregate the right to purchase  1,245,058
shares of Common Stock  pursuant to Techne's 1987  Incentive  Stock Option Plan,
1997  Incentive  Stock Option Plan and 1988  Nonqualified  Stock Option Plan are
outstanding as of the date hereof.

     (c) Except as set forth in paragraphs (a) and (b) of this Section 3.3 or as
a result of the exercise of outstanding  options,  there are not, as of the date
hereof,  any other shares of Techne  capital stock  authorized or outstanding or



any subscriptions,  options, conversion or exchange rights, warrants, repurchase
or redemption agreements, or other agreements or commitments,  obligating Techne
to issue,  transfer,  sell, repurchase or redeem any shares of its capital stock
or other  securities  of Techne.  There are no written  stockholder  agreements,
voting trusts,  proxies or other agreements,  instruments or understandings with
respect to the voting of the capital stock of Techne.

     3.4 No Violation of Agreements.  Neither the execution and delivery of this
Agreement nor the consummation of the transactions contemplated hereunder by R&D
or  Techne  will  violate  or  conflict  with  any  law,  contract,  note,  debt
instrument, security agreement or mortgage, or any other commitment binding upon
R&D or Techne that has or is likely to have a Material Adverse Effect.

     3.5 Techne Commission Filings; Financial Statements.  Techne has previously
delivered to Genzyme its (a) Annual  Report on Form 10-K for the year ended June
30,  1997 as filed with the  Commission;  (b) all proxy  statements  relating to
meetings of Techne  stockholders  held or  currently  scheduled to be held since
June 30, 1997;  and (c) all other  reports  filed by Techne with the  Commission
under the Exchange Act since June 30, 1997. As of the respective  dates of their
filing with the Commission, all reports, statements, registration statements and
other filings (including all notes, exhibits and schedules thereto and documents
incorporated  by reference  therein) filed by Techne with the  Commission  since
June 30,  1997 (such  reports,  statements,  registration  statements  and other
filings,  together with any amendments  thereto,  being  sometimes  collectively
referred  to as the  "Techne  Commission  Filings")  complied  in  all  material
respects  with  the  requirements  of the  Securities  Exchange  Act and did not
contain,  at the time of the filing thereof,  any untrue statement of a material
fact or omit to state a material fact required to be stated therein or necessary
to make the statements made therein,  in light of the circumstances  under which
they were made, not misleading.  Each of Techne's audited consolidated financial
statements dated June 30, 1997 and unaudited  consolidated  financial statements
dated  September 30, 1997,  December 31, 1997 and March 31, 1998  (including any
related  notes or  schedules)  included  in the Techne  Commission  Filings  was
prepared in accordance with generally accepted accounting  principles applied on
a  consistent  basis  (except  as may be  indicated  therein  or in the notes or
schedules  thereto) and fairly presents the financial position of Techne and its
consolidated  Subsidiaries  (as defined  below) as at the dates  thereof and the
results of their  operations  and changes in financial  position for the periods
then ended, subject, in the case of unaudited interim financial  statements,  to
normal year end adjustments which are not materially adverse.  Techne has timely
filed with the Commission all reports  required to be filed under Section 13, 14
or 15 of the Exchange Act since June 30, 1997.

     3.6 Conduct of Business in the Ordinary Course;  Absence of Certain Changes
and Events.  Except as disclosed in Techne  Commission  Filings  filed as of the
date hereof, Techne's unaudited consolidated financial statements for the fiscal
period ended March 31, 1998  previously  delivered to Genzyme,  or Schedule 3.6,
since June 30, 1997, there has not been,  occurred or arisen,  whether or not in
the ordinary course of business:



          (i) any  damage  or  destruction  in the  nature  of a  casualty  loss
     (including,  without  limitation,  any  occurrence  affecting  the  soil or
     groundwater  condition of any real  property  presently or formerly  owned,
     operated  or  leased by Techne or its  Subsidiaries),  whether  covered  by
     insurance or not, having a Material Adverse Effect; or

          (ii) any declaration,  setting aside or payment of a dividend (whether
     in cash, stock, or property) in respect of, or repurchase or redemption of,
     the capital stock of Techne or any of its Subsidiaries (other than a wholly
     owned Subsidiary); or

          (iii) any actual or, to the  knowledge  of Techne,  threatened  strike
     (whether  asserted  or  unasserted)  or  other  labor  trouble  or  dispute
     involving  employees of Techne or any of its Subsidiaries  which has had or
     is having a Material Adverse Effect; or

          (iv) any borrowing or lending of money or guarantee of any  obligation
     by Techne nor any of its  Subsidiaries,  except in the  ordinary  course of
     business; or

          (v) any application,  amendment,  termination,  renewal based on false
     and  misleading  disclosures  or  failure  to renew  with  respect  to, any
     agreement or insurance policy which has a Material Adverse Effect; or

          (vi) any disposition of any material  properties or assets used in the
     business of Techne or its Subsidiaries  except sales from inventory made in
     the ordinary course of business; or

          (vii) any violation of or conflict with any applicable laws, statutes,
     orders,  rules and  regulations  promulgated  or  judgment  entered  by any
     federal,  state, county,  local or foreign court or governmental  authority
     which,  individually  or in the aggregate,  has had or is having a Material
     Adverse  Effect (or insofar as Techne knows,  can reasonably be foreseen to
     have a Material Adverse Effect); or

          (viii)  any  notice  or  any   violation  or   investigation   by  any
     governmental  authority that has had or is having a Material Adverse Effect
     (or, insofar as Techne knows, can reasonably be foreseen to have a Material
     Adverse Effect);

          (ix) any other Material Adverse Change.

     3.7  Litigation.  Except as disclosed in the Techne  Commission  Filings or
Schedule 3.7, no action, suit, proceeding or investigation is pending or, to the
best  knowledge  of the  officers of R&D and Techne,  threatened  against R&D or
Techne nor, to the best  knowledge of the  officers of R&D and Techne,  is there
any basis  therefor;  provided,  however,  that the foregoing  includes only any
actions,  suits,  proceedings and investigations,  pending or threatened,  which
questions the validity of this  Agreement or the right of R&D or Techne to enter
into it or to take any action in connection  with it, or which can reasonably be
foreseen  to result,  either  individually  or in the  aggregate,  in a Material
Adverse Effect.



     3.8 Governmental and Other Consents. No consent,  approval or authorization
of, or designation,  declaration or filing with, any  governmental  authority or
any  securities  exchange  or market on the part of R&D or Techne is required in
connection  with the valid  execution  and  delivery of this  Agreement,  or the
offer, sale, or issuance of the Shares,  except the qualification,  if required,
of the Shares under applicable state  securities laws, which  qualification  has
been affected,  and other routine  post-closing  filings under  applicable state
securities laws, which filings will be completed on a timely basis.

     3.9 Offering.  Relying in part on the accuracy of the representations  made
by Genzyme in the Stockholder's  Rights Agreement,  the offer, sale and issuance
of the  Shares  in  conformity  with  the  terms  of this  Agreement  constitute
transactions  exempt  from the  registration  requirements  of  Section 5 of the
Securities Act of 1933, as amended.

     3.10  No  Conflicting  Agreements.  To  the  best  of  R&D's  and  Techne's
knowledge,  no employee of R&D or Techne is, or will be in  connection  with the
operations or proposed operations of R&D and Techne, in violation of any term of
any employment contract,  proprietary  information and inventions agreement,  or
any  other  contract  or  agreement  relating  to the  relationship  of any such
employee with R&D or Techne or any previous employer.

     3.11  Subsidiaries.  Except as set forth on Schedule 3.11 (the entities set
forth therein being referred to as the  "Subsidiaries"),  neither R&D nor Techne
presently owns or controls,  directly or  indirectly,  or has any stock or other
material   interest  as  owner  or  principal  in,  any  other   corporation  or
partnership, joint venture, association or other business venture or entity.

     3.12 Tax  Matters.  Each of R&D and Techne  have  accurately  prepared  and
timely  filed all income tax returns and other tax returns  required to be filed
by them and has paid, or made provision for the payment of, all taxes which have
or may have become due  pursuant to said  returns or pursuant to any  assessment
which has been received by either of them, and with respect to which the failure
to prepare, file, pay or make provision for would have a Material Adverse Effect
on either R&D or Techne.

     3.13 Insurance. The policies of fire, liability, workmen's compensation and
other forms of  insurance  in effect  with  respect to R&D and Techne are valid,
outstanding  and  enforceable  policies  and,  except  with  respect  to product
liability,  provide continuous and adequate insurance coverage for the property,
assets and operations of R&D,  without lapse,  on an occurrence  basis.  R&D and
Techne have not been refused any  insurance nor has its coverage been limited by
any  insurance  carrier to which it has  applied for  insurance  during the last
three (3) years. With respect to product liability insurance, R&D and Techne are
self-insured.

     3.14  Environmental  and Safety Laws. To the best of their  knowledge,  (a)
neither  R&D  nor  Techne  is in  violation  of an  applicable  statute,  law or
regulation  relating to the environment or occupational  health and safety,  and
(b) no material  expenditures  which would have a Material Adverse Effect are or
will be  required  in order to comply  with any such  existing  statute,  law or
regulation.



     3.15 No Brokers.  Neither R&D nor Techne has  incurred  any  liability  for
brokerage,  finder's or agent's  fees or  commissions  in  connection  with this
Agreement or any transaction contemplated hereunder.

4.   COVENANTS OF GENZYME PRIOR TO CLOSING DATE

     4.1 Access and  Investigation.  Between the date of this  Agreement and the
Closing Date, Genzyme will:

     (a) afford R&D reasonable access to the personnel,  properties,  contracts,
books and records,  and other documents and data of Genzyme  associated with the
Business;

     (b) furnish R&D with copies of all such contracts,  books and records,  and
other existing documents and data as R&D may reasonably request; and

     (c) furnish R&D with such additional financial,  operating,  and other data
and information as R&D may reasonably request.

     Notwithstanding  the  foregoing,  R&D will not be  entitled  access  to the
customer and mailing lists referenced in Schedule 1.2(d) until the Closing.

     4.2 Operation of the Business.  Between the date of this  Agreement and the
Closing Date, Genzyme will:

     (a) conduct the Business only in the Ordinary Course of Business;

     (b)  use  its  Best  Efforts  to  preserve  intact  the  current   business
organization  of the Business,  keep available the services of current sales and
service  employees,  and maintain the  relations  and good will with  suppliers,
customers,  employees, agents, and others having business relationships with the
Business;

     (c) confer with R&D concerning  operational  matters of a material  nature;
and

     (d)  otherwise  report  periodically  to R&D  concerning  the status of the
business and operations of the Business.

     4.3  Negative  Covenant.  Except as otherwise  expressly  permitted by this
Agreement, between the date of this Agreement and the Closing Date, Genzyme will
not, without the prior consent of R&D, take any affirmative  action,  or fail to
take any reasonable  action within its control,  as a result of which a Material
Adverse Change is likely to occur.

     4.4  Required  Approvals.  To the  extent  it has not  already  done so, as
promptly as practicable after the date of this Agreement,  Genzyme will make all




filings  required by Legal  Requirements to be made by it in order to consummate
the Transaction  (including all filings under the HSR Act).  Between the date of
this Agreement and the Closing Date, Genzyme will:

     (a)  reasonably  cooperate with R&D with respect to all filings that R&D or
Techne elects to make or is required by Legal Requirements to make in connection
with the Transaction; and

     (b) reasonably  cooperate with R&D in obtaining all consents  identified in
Section 6.2.

     4.5 Notification.  Between the date of this Agreement and the Closing Date,
Genzyme will promptly  notify Techne and R&D in writing if Genzyme becomes aware
of any fact or condition that causes or constitutes a Breach of any of Genzyme's
representations  and warranties as of the date of this Agreement,  or if Genzyme
becomes aware of the occurrence  after the date of this Agreement of any fact or
condition that would (except as expressly  contemplated by this Agreement) cause
or  constitute  a  Breach  of any  such  representation  or  warranty  had  such
representation  or warranty  been made as of the time of occurrence or discovery
of such fact or condition.

     4.6 No  Negotiation.  Until  such  time,  if  any,  as  this  Agreement  is
terminated  pursuant to Section  16.3,  Genzyme will not directly or  indirectly
solicit,  initiate,  or encourage  any inquiries or proposals  from,  discuss or
negotiate with, provide any non-public information to, or consider the merits of
any  unsolicited  inquiries or proposals from, any person (other than Techne and
R&D)  relating to any  transaction  involving the sale of the Business or assets
(other than in the Ordinary Course of Business) of the Business,  or any merger,
consolidation,  business  combination,  or  similar  transaction  involving  the
Business.

     4.7 Best  Efforts.  Between  the date of this  Agreement  and the  Closing,
Genzyme will use its Best Efforts to cause the conditions in Sections 6 and 7 to
be satisfied.

5.   COVENANTS OF TECHNE AND R&D

     5.1 Approvals of Governmental Bodies. To the extent it has not already done
so, as promptly as practicable after the date of this Agreement,  Techne and R&D
will  make all  filings  required  by Legal  Requirements  to be made by them to
consummate the  Transaction  (including all filings under the HSR Act).  Between
the date of this  Agreement  and the  Closing,  Techne  and R&D will  reasonably
cooperate  with  Genzyme with respect to all filings that Genzyme is required by
Legal  Requirements to make in connection with the  Transaction,  and reasonably
cooperate  with Genzyme in obtaining  all  consents  identified  in Section 6.2;
provided  that this  Agreement  will not require  Techne or R&D to dispose of or
make any change in any portion of their business or to incur any other burden to
obtain a Governmental Authorization.

     5.2 Access and  Investigation.  Between the date of this  Agreement and the
Closing,  R&D  and  Techne  will  allow  Genzyme,   through  its  employees  and
representatives,  to have access to the contracts,  books,  records,  documents,



personnel, assets, properties, business, operations and other information of R&D
and Techne as Genzyme may reasonably  request in connection with its examination
of R&D and Techne with respect to the Transaction.

     5.3 Notification.  Between the date of this Agreement and the Closing Date,
R&D  and/or  Techne  will  promptly  notify  Genzyme in writing if R&D or Techne
becomes  aware of any fact or condition  that causes or  constitutes a Breach of
any of R&D's or Techne's  representations  and warranties as of the date of this
Agreement, or if R&D or Techne becomes aware of the occurrence after the date of
this  Agreement  of any  fact or  condition  that  would  (except  as  expressly
contemplated  by this  Agreement)  cause  or  constitute  a  Breach  of any such
representation  or warranty had such  representation or warranty been made as of
the time or occurrence or discovery of such fact or condition.

     5.4 No  Negotiation.  Until  such  time as  this  Agreement  is  terminated
pursuant  to  Section  16.3,  R&D and Techne  will not  directly  or  indirectly
solicit,  initiate or encourage  any  inquiries or  proposals  from,  discuss or
negotiate with, provide any non-public information to, or consider the merits of
any  unsolicited  inquiries or proposals  from,  any person (other than Genzyme)
relating  to any  transaction  involving  the  purchase  of a business or assets
substantially  similar to the Business  and Assets to be  purchased  pursuant to
this Agreement  (other than in the ordinary course of business),  or any merger,
consolidation,  business combination or similar transaction involving a business
or assets  substantially  similar to the  Business  and  Assets to be  purchased
pursuant to this Agreement.

     5.5 Best  Efforts.  Between  the date of this  Agreement  and the  Closing,
Techne and R&D will use their Best Efforts to cause the conditions in Sections 6
and 7 to be satisfied.

6.   CONDITIONS PRECEDENT TO OBLIGATIONS OF TECHNE AND R&D

     The   obligations  of  Techne  and  R&D  to  consummate  the   transactions
contemplated  by this  Agreement  shall  be  subject,  at their  option,  to the
fulfillment at or prior to Closing of each of the following conditions:

     6.1  Conveyance  and  Assignment.  Genzyme  shall  have duly  executed  and
delivered  to  R&D  each  of  the  Conveyance   Documents,   to  the  reasonable
satisfaction of R&D and its counsel,  required by Section 1.8 hereof,  above, to
sell, convey,  assign,  grant and otherwise transfer to R&D all right, title and
interest in and to the Assets.

     6.2  Consents.  R&D shall have  received  evidence,  in form and  substance
reasonably  satisfactory  to R&D and its counsel,  that such licenses,  permits,
consents,  approvals,  waivers,  authorizations,  qualifications  and  orders of
governmental  authorities and parties to contracts with Genzyme as are necessary
for the  consummation  of the  transaction  have been  diligently  requested  or
obtained.

     6.3 Accuracy of Representations  and Warranties.  The  representations  and
warranties of Genzyme contained in this Agreement shall be accurate and complete
in all  material  respects on and as of the date of Closing with the same effect
as though such  representations  and  warranties had been made on and as of such
date and  Genzyme  shall have  delivered  to R&D a  certificate  to that  effect
executed by Genzyme and dated as of the date of Closing.



     6.4 Performance of Agreements. Each and all of the conditions precedent and
agreements of Genzyme  subject to  satisfaction on or before the date of Closing
pursuant to the terms of this  Agreement  shall have been performed or satisfied
in all material  respects and Genzyme shall have  delivered to R&D a certificate
to such effect executed by Genzyme and dated as of the date of Closing.

     6.5 Actions or Proceedings.  No action,  suit or other proceeding  before a
court,  tribunal  or other  governmental  agency  or body not  disclosed  on the
Schedules  hereto  shall have been  instituted  or  threatened  to  restrain  or
prohibit the consummation of the transactions contemplated by this Agreement, or
seeking to obtain substantial  damages in respect thereof,  or involving a claim
that  consummation  thereof would result in the violation of any law,  decree or
regulation of any governmental  authority having  appropriate  jurisdiction that
would otherwise have a Material Adverse Effect.

     6.6  Stockholder's  Rights  Agreement.  Genzyme  shall  have  executed  the
Stockholder's  Rights  Agreement in the form attached hereto as Exhibit 6.6 (the
"Stockholder's Rights Agreement").

     6.7 No Adverse Change. There shall have been no event since the date hereof
which has occurred or which has been  disclosed to R&D which has had or could be
reasonably expected to have a Material Adverse Effect.

     6.8 Court Orders.  No preliminary  or permanent  injunction or other order,
decree or ruling issued by a court of competent jurisdiction or by a government,
regulatory  or  administrative  agency  or  commission  nor any  statute,  rule,
regulation  or  executive  order  promulgated  or  enacted  by any  governmental
authority  shall be in effect which would make the acquisition or holding by R&D
of the Assets illegal or impose material  limitations on its ability to exercise
full rights of ownership with respect to such Assets.

     6.9 Opinion of Counsel for Genzyme.  On the date of the Closing counsel for
Genzyme shall have delivered to R&D and Techne an opinion,  dated as of the date
of Closing, in substantially the form of Exhibit 6.9.

     6.10  Additional  Documents.  Genzyme  shall  have  delivered  to R&D  such
documents and instruments as R&D may reasonably  request in connection with this
Agreement  and  the  consummation  of  the  transactions   contemplated  hereby,
including  the  documents and  certificates  listed on the Closing  Agenda to be
furnished by Genzyme to R&D.

     6.11 HSR Act. As of the date of Closing,  all waiting periods applicable to
the consummation of the Acquisition under the HSR Act shall have expired or been
terminated.



     6.12 Minimum  Average  Market Price.  The Average Market Price shall be not
less than $16.00 per share.

7.   CONDITIONS PRECEDENT TO OBLIGATIONS OF GENZYME

     The obligations of Genzyme to consummate the  transactions  contemplated by
this Agreement shall be subject,  at Genzyme's  option, to the fulfillment at or
prior to Closing of each of the following conditions:

     7.1 Purchase  Price.  Techne shall have delivered the Purchase Price at the
Closing as provided in Section 1.3.

     7.2 Accuracy of Representations  and Warranties.  The  representations  and
warranties of R&D and Techne  contained in this Agreement  shall be accurate and
complete on and as of the date of Closing  with the same effect as through  such
representations  and  warranties had been made on or as of such date and R&D and
Techne shall have delivered to Genzyme a certificate to that effect signed by an
officer of R&D and an officer of Techne, and dated as of the date of Closing.

     7.3 Performance of Agreements. Each and all of the conditions precedent and
agreements of R&D and of Techne subject to satisfaction on or before the date of
Closing  pursuant to the terms of this  Agreement  shall have been  performed or
satisfied and R&D and Techne shall have  delivered to Genzyme a  certificate  to
that effect  signed by an officer of R&D and an officer of Techne,  and dated as
of the date of Closing.

     7.4 Actions or Proceedings.  No action,  suit or other proceeding  before a
court,  tribunal or other governmental agency or body shall have been instituted
or  threatened  to restrain or prohibit  the  consummation  of the  transactions
contemplated  by this  Agreement,  or seeking to obtain  substantial  damages in
respect thereof, or involving a claim that consummation  thereof would result in
the violation of any law,  decree or regulation  of any  governmental  authority
having  appropriate  jurisdiction,  or in  connection  with any  material  claim
against R&D not disclosed on the Schedules hereto.

     7.5  Opinion  of Counsel  for R&D and  Techne.  On the date of the  Closing
counsel for R&D and Techne shall have delivered to Genzyme an opinion,  dated as
of the date of Closing, in the form of Exhibit 7.5.

     7.6  Stockholder's  Rights  Agreement.   Techne  shall  have  executed  and
delivered the  Stockholder's  Rights  Agreement in the form  attached  hereto as
Exhibit 6.6.

     7.7 No Adverse Change. There shall have been no event since the date hereof
which has occurred or which has been disclosed to Genzyme which has had or could
be reasonably expected to have a Material Adverse Effect.



     7.8 Court Orders.  No preliminary  or permanent  injunction or other order,
decree or ruling issued by a court of competent jurisdiction or by a government,
regulatory  or  administrative  agency  or  commission  nor any  statute,  rule,
regulation  or  executive  order  promulgated  or  enacted  by any  governmental
authority  shall be in effect which would make the acquisition or holding by R&D
of the Assets illegal or impose material  limitations on its ability to exercise
full rights of ownership with respect to such Assets.

     7.9 HSR Act. As of the date of Closing,  all waiting periods  applicable to
the consummation of the Acquisition under the HSR Act shall have expired or been
terminated.

8.   ROYALTIES

     8.1 Royalty  Payment.  In  consideration  of the  transfer of the Assets by
Genzyme to R&D, R&D shall pay to Genzyme the "Royalty," as described in Schedule
8.1 in the manner indicated in Section 8.2.

     8.2 Manner of Payment.

     (a) The Royalty shall be paid in U.S.  dollars by R&D to Genzyme  quarterly
by the forty-fifth  (45th) day following the end of each calendar quarter (i.e.,
on May 15,  August 14,  November 15 and February 14) of each year.  In the event
that any sum of money owed to Genzyme as Royalties  hereunder is not paid either
(i) with respect to any basic Royalty amount,  when due, or (ii) with respect to
any corrected  Royalty amount,  within twenty (20) days after  correction to the
statement  accompanying  each Royalty payment based on a correction  found to be
necessary by Genzyme,  R&D or an audit under Section 8.3, then the unpaid amount
shall bear interest from the date  originally  due,  compounded  monthly,  at an
annual  rate of two (2)  percentage  points  above the  published  prime rate of
BankBoston,  N.A. on the day such payment was due, or at the highest annual rate
permitted by law, whichever is lower, until paid.

     (b) Royalty payments shall be accompanied by a written statement showing in
reasonable  detail  royalty  bearing  sales  occurring  during  the period and a
computation  of  the  relevant  Royalty  payment.  This  written  statement  and
attachments   thereto  shall  be  treated  by  Genzyme  as  Techne  Confidential
Information pursuant to Section 11.

     (c) R&D shall provide to Genzyme upon reasonable  request an annual report,
not later than the sixtieth  (60th) day following the end of the fiscal year, on
all royalty-bearing sales occurring during such fiscal year.

     8.3 Audit and  Inspection  Rights.  R&D shall  keep  books and  records  in
sufficient  detail to enable the Royalty to be determined  and shall retain such
records for each  calendar  quarter for a minimum of three years from the end of
such calendar quarter. Upon reasonable notice and during regular business hours,
R&D shall make available such records for audit by an independent agent selected
by  Genzyme,  subject  to the  independent  agent's  execution  of a  reasonable
confidentiality  agreement,  to verify the  accuracy of the reports  provided to
Genzyme. Any such audit shall be performed at Genzyme's expense,  except if such
audit reveals  underpayments by R&D of more than the lesser of five percent (5%)
of the correct amount of Royalties due hereunder or $25,000,  whichever is less,
during any quarter then such audit shall be at the sole expense of R&D.



9.   MANUFACTURING AND TECHNICAL ASSISTANCE BY GENZYME

     Promptly  after the Closing,  Genzyme  shall provide R&D with the originals
and all but one copy  (retained  solely for  archival  purposes) of the tangible
manifestations  of the  Technology,  including but not limited to all documents,
pictures,  writings and cell cultures  embodying any of the  Technology,  to the
extent that Genzyme owns or can transfer such tangible  manifestations.  Genzyme
also  agrees to provide to R&D such  further  Technology  which is not  tangibly
manifested,  including its expertise and know-how, as is reasonably necessary or
useful  to  enable  R&D to carry on the  current  commercial  activities  of the
Business or to make  meaningful use of the  Technology.  In connection  with the
transfer of such  Technology,  Genzyme shall make  available to R&D at Genzyme's
Cambridge, Massachusetts facility, for up to 30 hours per week not to exceed 300
hours in the  aggregate  during the three  months  following  the  Closing,  the
services of competent and knowledgeable manufacturing and technical personnel to
confer with R&D personnel  concerning the Technology.  Any services  provided by
Genzyme  personnel  pursuant  to this  Section 9 in excess of 300 hours or after
three months  following  the Closing  shall be reimbursed by Techne at Genzyme's
fully-burdened cost.

10.  TRANSITION SALES AND MANUFACTURING OBLIGATION

     10.1 Sales of  Inventory.  For not more than 31 days after the  Closing but
prior to physical  transfer of the  Inventory in  accordance  with Schedule 1.9,
Genzyme  shall  continue to accept  purchase  orders for the  Genzyme  Products,
including  purchase  orders  placed by R&D for  shipment  to third  parties  and
purchase orders placed directly with Genzyme by third parties,  and to fill such
purchase  orders from the Inventory  ("Inventory  Sales").  Genzyme shall not be
obligated  to accept  or fill any  orders  that  cannot  be  satisfied  from the
Inventory  or from  production  manufactured  at the request of R&D  pursuant to
Section 10.2.  Genzyme shall issue invoices for such  Inventory  sales and shall
collect  payment of such  invoices.  The amounts of all such  invoices  shall be
credited  against the next Royalty payment due under Section 8.1. Within 10 days
of the end of such  period,  Genzyme  shall  provide to R&D a written  statement
showing in  reasonable  detail the amount of such  invoices.  Genzyme shall keep
books and records in  sufficient  detail to enable R&D to verify the accuracy of
the report it provided to R&D and shall retain such records for three years from
the end of such  period.  Upon  reasonable  notice and during  regular  business
hours,  Genzyme shall make  available  such records for audit by an  independent
agent  selected by R&D to verify the  accuracy  of the report  provided by it to
R&D.

     10.2  Products  and  Pricing.  For  three  months  from  the  Closing  (the
"Transition Period"),  Genzyme agrees to sell to R&D and R&D agrees to buy those
Genzyme  Products  of the type that  Genzyme  manufactured  prior to Closing (as
opposed  to those  Genzyme  Products  purchased  by Genzyme  from a third  party
manufacturer  for resale) in the quantities  indicated in a purchase order to be



provided by R&D to Genzyme within one (1) week following the Closing. Such sales
of Genzyme  Products  shall be at Genzyme's  Actual Cost of Production  therefor
plus 25%, but not to exceed two times the standard cost identified under Section
1.2(j).  For the purposes of conducting such  manufacture  during the Transition
Period,  R&D  grants  to  Genzyme  a  license  to make or have made for R&D such
products consistent with the Technology rights of the Business held by R&D.

     10.3  Sales  Support.  Prior  to  physical  transfer  of the  Inventory  in
accordance  with Schedule 1.9 and transfer of the 800 phone number  contained in
Schedule  1.2(g),  Genzyme  shall  provide  technical  support and sales support
("Support Services") to third party purchasers of Genzyme Products, whether such
Genzyme  Products  were sold by Genzyme prior to the Closing or are sold for the
account of R&D after the Closing. Following the transfer of Inventory, R&D shall
provide the Support  Services (a) to all third party  purchasers of such Genzyme
Products and (b) to all  purchasers of products  sold by R&D in connection  with
any use of the "Genzyme" name or trademark or tradename acquired hereunder. Each
party shall provide such Support Services at a level of quality characterized by
the Support Services currently provided by Genzyme to its customers.

     10.4  Warranty.  Genzyme  warrants that the products  purchased by R&D from
Genzyme  under Section 10.2 will be in accordance  with the  Specifications  for
Products  as set forth in Schedule  2.9  attached  hereto.  In the event that an
inventory  item does not conform  with its  Specifications  for  Products,  upon
written notice from R&D specifying such non-conformity, Genzyme shall at its own
cost without  unreasonable  delay deliver new product for the replacement of the
defective quantity or R&D shall be credited against the next Royalty payment due
pursuant  to  Section  8.1  the  cost  of the  defective  item.  Upon  Genzyme's
direction,  R&D shall either return such defective quantity at Genzyme's cost or
destroy it. Genzyme's  obligations  under the second and third sentences of this
Section 10.4 shall terminate, in the case of finished goods, upon the expiration
date  of  such  goods  on  a  product-by-product  basis,  and  in  the  case  of
work-in-process and raw materials, six months from the date of Closing.

     10.5 Force Majeure. With respect to this Section 10, neither of the parties
shall be liable in any manner for failure or delay in the  fulfillment of all or
any  part  of  this  Agreement  directly  or  indirectly  owing  to Acts of God,
governmental  orders or restrictions,  war, threat of war, war-like  conditions,
hostilities, sanctions, mobilization,  blockade, embargo, detention, revolution,
riot, looting,  strike,  lockout,  plague, fire, flood,  earthquake or any other
cause or other  circumstances  beyond the affected party's control.  Each of the
parties shall take all reasonable  steps to minimize the effect of force majeure
upon it and performance  under this Agreement shall continue  promptly after any
such  effect of force  majeure  has abated.  Notice of any  occurrence  of force
majeure  affecting  either  party  shall be given to the other  party as soon as
possible  together with evidence thereof and the expected duration of the period
for which performance hereunder shall be delayed.



11.  NONUSE AND NONDISCLOSURE

     11.1 Protection of Confidential Information.

     (a) R&D and Techne understand and agree that  confidentiality  with respect
to  the  subject  matter  and  performance  of  this  Agreement  is  of  extreme
importance,  and any breach or violation  of an  obligation  of  confidentiality
hereunder  by R&D or Techne  may  result in  material  and  irreparable  harm to
Genzyme.  R&D and Techne will hold in  confidence  and use their Best Efforts to
have all of their respective employees,  agents,  representatives and affiliated
companies  hold in  confidence  all Genzyme  Confidential  Information  which is
disclosed  by  Genzyme  or its  agents to R&D or Techne in  connection  with the
transactions  contemplated  by this  Agreement  (including,  but not limited to,
customer lists and intellectual property rights), and not disclose, publish, use
or permit others to use the same. R&D and Techne  acknowledge that Genzyme shall
be entitled,  in addition to all other  available  remedies,  to injunctive  and
other equitable  relief to prevent or remedy any breach of this Agreement and to
secure performance under this Agreement.

     (b) Genzyme understands and agrees that confidentiality with respect to the
subject matter and performance of this Agreement is of extreme  importance,  and
any breach or violation of an obligation of confidentiality hereunder by Genzyme
may result in material and irreparable harm to R&D or Techne.  Genzyme will hold
in confidence and use its Best Efforts to have all of its respective  employees,
agents,  representatives and affiliated  companies hold in confidence all Techne
Confidential  Information which is disclosed by R&D or Techne or their agents to
Genzyme in  connection  with the  transactions  contemplated  by this  Agreement
(including,  but not  limited  to,  customer  lists  and  intellectual  property
rights),  and not  disclose,  publish,  use or  permit  others  to use the same.
Genzyme  acknowledges that R&D and Techne shall be entitled,  in addition to all
other available remedies, to injunctive and other equitable relief to prevent or
remedy  any  breach of this  Agreement  and to  secure  performance  under  this
Agreement.

     (c) Prior to the Closing,  Genzyme will hold in confidence and use its Best
Efforts to have all of its respective  employees,  agents,  representatives  and
affiliated  companies hold in confidence  all  Transferred  Information  and not
disclose,  publish, use or permit others to use the same.  Immediately following
the Closing,  Genzyme will notify its  employees,  agents,  representatives  and
affiliated  companies  that  it  has  transferred  all  rights  in  and  to  the
Transferred  Information  and shall  notify  them of the  obligation  under this
Section 11 to maintain such Transferred Information in confidence.

      11.2     Nonuse.

     (a) R&D and  Techne  will  use  Genzyme  Confidential  Information  only in
connection  with  their  evaluation  of the  transaction  contemplated  by  this
Agreement  and the  performance  of  their  obligations  hereunder.  Such use of
Genzyme Confidential Information shall be made only until this Agreement expires
or  otherwise  terminates.  Other  than as is  contemplated  by this  Agreement,
neither R&D nor Techne will in any way use any Genzyme Confidential  Information
for its own benefit or the benefit of any third party.



     (b) Genzyme will use Techne  Confidential  Information  only in  connection
with its evaluation of the  transaction  contemplated  by this Agreement and the
performance  of its  obligations  hereunder.  Such  use of  Techne  Confidential
Information  shall be made  only  until  this  Agreement  expires  or  otherwise
terminates. Other than as is contemplated by this Agreement, Genzyme will not in
any way use any  Techne  Confidential  Information  for its own  benefit  or the
benefit of any third party.

     11.3 Exceptions.  The provisions  contained in Section 11.1, 11.2, 11.5 and
11.6 will not apply to any specific Confidential Information which:

     (a) at the time of disclosure to the receiving party is part of, or without
violation of this Agreement or fault of the receiving  party has become part of,
the public  knowledge or  literature  and readily  accessible  to a third party,
provided  that any  combination  of  features  shall not be deemed  within  this
exception merely because individual features are part of the public knowledge or
literature  and  readily  accessible  to  such  third  party,  but  only  if the
combination  itself  and its  principle  of  operation  are  part of the  public
knowledge or literature and readily accessible to such third party;

     (b) is lawfully  obtained by the receiving party from a third party without
breach of an obligation of confidence;

     (c) the  receiving  party  can show by  reliable  documentation  was in its
possession, free of any obligation of confidentiality, at the time of disclosure
to it by the other party; or

     (d) is required by law or court order to be disclosed.

     11.4 Partial  Disclosures.  In the event that any Confidential  Information
shall be in any way disclosed to any party other than as is contemplated by this
Agreement,  or is any way  released  into the public  domain,  all  Confidential
Information  that is not so  disclosed  or released  shall  nevertheless  remain
subject to the provisions of this Section 11.

     11.5  Disclosure  to R&D and Techne  Employees.  All of R&D's and  Techne's
employees to whom any of the Genzyme Confidential Information has been disclosed
or is to be disclosed  (and any third party who is to have access to the Genzyme
Confidential   Information)   shall  have  executed   R&D's   standard  form  of
confidentiality  agreement,  attached  hereto as Exhibit 11.5. At the request of
Genzyme, or upon any termination of this Agreement,  R&D will promptly return to
Genzyme all items of Genzyme Confidential Information,  except that one copy may
be retained for archival purposes.



     11.6 Disclosure to Genzyme  Employees.  All of Genzyme's  employees to whom
any of the  Techne  Confidential  Information  has  been  disclosed  or is to be
disclosed (and any third party who is to have access to the Techne  Confidential
Information)  shall have executed  Genzyme's  standard  form of  confidentiality
agreement,  attached  hereto as Exhibit 11.6. At the request of Techne,  or upon
any  termination of this  Agreement,  Genzyme will promptly return to Techne all
items of Techne Confidential  Information,  except that one copy may be retained
for archival purposes.

12.  INTELLECTUAL PROPERTY INDEMNITY, LIABILITIES AND LIMITATIONS

     12.1 Genzyme Intellectual Property Disclaimer. Genzyme does not warrant (i)
the  validity  or scope of any  patent  right  which is an  Asset,  or (ii) that
anything  derived  or  substantially  derived  from the  Technology  or  Genzyme
Products  provided  hereunder is or will be free from infringement of patents or
intellectual  property of third  persons.  However,  Genzyme does  represent and
warrant  that,  except as  disclosed  to R&D and Techne in writing  prior to the
Closing,  to the best of its knowledge after reasonable  inquiry that no Genzyme
Product  infringes  any  patents or  intellectual  property  rights of any third
person.

     12.2  Infringement  Indemnity by R&D. R&D will defend  Genzyme  against and
indemnify Genzyme for any damages finally awarded or settlement  amounts paid in
respect of a claim made against Genzyme that R&D's use of the Technology or sale
of Genzyme Products after the Closing  infringes any third party's  intellectual
property  rights,  provided that Genzyme  notifies R&D in writing  within twenty
(20) days of any such claim.  R&D shall have full  control  over the defense and
settlement of any such claim.

     12.3 Infringement Indemnity by Genzyme. Genzyme will defend R&D against and
indemnify  R&D for any damages  finally  awarded or  settlement  amounts paid in
respect of a claim made against R&D or its Affiliates  that Genzyme's use of the
Technology  or sale of  Genzyme  Products  after  the  Closing  and  during  the
Transition  Period  infringes any third party's  intellectual  property  rights,
provided  that R&D notifies  Genzyme in writing  within  twenty (20) days of any
such claim.  Genzyme shall have full control over the defense and  settlement of
any such claim.

     12.4  Discovering  and  Reporting  Infringements.  Subsequent  to  closing,
Genzyme  shall  promptly  report to R&D any third  party  infringement  of R&D's
rights in and any patents related to the Technology or the Genzyme Products.

     12.5 No  Trademark  Rights.  Except as provided in Sections  1.2 and 13, no
party is  hereby  acquiring  any  right in or to any  other  party's  name,  any
abbreviation  thereof,  name acronym,  its logotype,  or other trademarks or any
trade name of another party.

13.  TRADEMARK LICENSE

     13.1 Grant of License.  The Assets sold hereunder include all rights, title
and  interest  in and  to  those  trademarks,  trade  names  and  service  marks
identified in Schedule 1.2(e).  Genzyme uses other  trademarks,  trade names and
services marks in connection  with the Business,  all of which are identified in



Schedule 13.1 (collectively,  the "Licensed Trademarks").  Genzyme grants to R&D
and Techne and their Affiliates a nonexclusive,  worldwide, royalty-free license
(without right of sublicense) to use the Licensed  Trademarks in connection with
sales of Genzyme Products, including any substantial equivalents thereof and any
enhancements or other  modifications  thereof made in the ordinary course of the
business. R&D, Techne and their respective Affiliates admit the validity of, and
agree  not to  challenge,  the  Licensed  Trademarks.  All  use of the  Licensed
Trademarks  by Techne,  R&D and their  Affiliates  shall inure to the benefit of
Genzyme.

     13.2  Quality  Control.  R&D,  Techne  and their  Affiliates  shall use the
Licensed  Trademarks in conformance with Genzyme's  standards and such use shall
be under Genzyme's sole control.  However,  Genzyme acknowledges that use of the
Licensed  Trademarks shall be in compliance with Genzyme's  standards so long as
the products sold  thereunder are  manufactured in a facility which is certified
by the United States Food and Drug  Administration  as meeting its GMP standards
or which is certified as meeting  standards  for CE  certification  for sales in
Europe and the  services  sold  thereunder  are  provided  at a level of quality
appropriate for and  characterized by the services  currently offered by Genzyme
under the relevant mark. Upon request by Genzyme,  R&D shall supply Genzyme with
specimens demonstrating how the Licensed Trademarks are used hereunder, and such
other  information  as may be reasonably  requested,  and to permit  reasonable,
periodic  inspection  of  the  operations  of  R&D  and/or  its  Affiliates,  at
reasonable  times and with reasonable  notice in order to determine  control and
quality level of products sold under the Licensed Trademarks.

     13.3 Term of License.  Unless  terminated  earlier under the  provisions of
Section 13.4, the license granted in Section 13.1 shall terminate on the earlier
of the date two years from the date of Closing,  the latest  expiration  date of
the Genzyme  Products  included in the Inventory or the date on which R&D ceases
to sell Genzyme  Products  included in the Inventory or  manufactured by Genzyme
for R&D  pursuant  to Section  10.2;  written  notice of which shall be promptly
provided to Genzyme.  At  termination,  R&D shall cease all use of the  Licensed
Trademarks, rights to which shall revert to Genzyme.

     13.4 Termination of License. If R&D or Techne shall breach any of the terms
of Sections 13.1 or 13.2 with respect to any particular  Licensed  Trademark(s),
Genzyme shall have the right to terminate the license granted  thereunder to use
the particular Licensed Trademark(s) by giving R&D and Techne 30 days' notice in
writing,  particularly  specifying the breach.  Such notice of termination shall
not be effective if the specified  breach is cured within said 30-day period or,
in the case of breaches not reasonably  curable  within said 30-day  period,  if
cure thereof is commenced  within said 30-day period and  diligently  thereafter
prosecuted.  R&D and Techne may terminate the  trademark  license  granted under
Section 13.1 at any time upon written notice.

     13.5 Additional Trademark.  After the Closing, Genzyme shall cooperate with
Techne in the  application for  registration as a trademark of  "Genzyme/Techne"
and any  reasonable  variations  thereof as may be agreed  upon by the  parties.
Techne  shall  have  exclusive,  royalty-free  rights to use such  trademark  in



connection with sale of all Genzyme Products and  scientifically  equivalent R&D
products in the  territories  listed on Schedule 13.5,  from the date of Closing
until the date two years from the date the termination  pursuant to Section 13.3
of the license granted pursuant to Section 13.1, but in no event later than four
(4) years following the Closing. Further, solely in the territories of Japan and
Italy,   Techne   shall  have   exclusive,   royalty-free   rights  to  use  the
Genzyme/Techne trademark and any reasonable variation thereof agreed upon by the
parties,  on Qualified Products (as defined in Schedule 8.1) until the date four
(4) years  following  the Closing  subject to the  following:  (i) Techne grants
Genzyme S.R.L.  rights  co-exclusive  with Techne's current Italian  distributor
(which  rights  shall be  transferable)  to  market  any  products  bearing  the
Genzyme/Techne   trademark  and  (ii)  Techne  will  provide  Genzyme's  current
distributors  in Japan  reasonable  access to market any  products  bearing  the
Genzyme/Techne  trademark.  All Genzyme Products and  corresponding R&D products
sold under the  Genzyme/Techne  trademark shall be of the same quality standards
as set  forth  in  Section  13.2.  Upon  expiration  of  this  right  to use the
Genzyme/Techne trademark,  Techne shall promptly cease use of such trademark but
retain the right to prohibit  and  prevent  use  thereof by any other  person or
party.

14.  INDEMNIFICATION

     14.1 Indemnification by Genzyme.

     (a) Genzyme hereby  indemnifies  R&D and Techne and agrees to hold harmless
and, at R&D's or Techne's  request,  defend R&D, Techne and R&D's  subsidiaries,
and the  affiliates,  directors,  officers,  employees,  agents and  independent
contractors  of each,  against  and in respect of any and all  damages,  losses,
deficiencies,  liabilities,  orders, claims, fines,  judgments,  costs, fees and
expenses, including, without limitation,  reasonable legal, accounting and other
fees and  expenses  (collectively,  "Damages"),  incurred  or suffered by R&D or
Techne as a result  of:  (i) any  breach by  Genzyme  of any  representation  or
warranty  made  by it  contained  in this  Agreement  or in any  other  document
delivered pursuant hereto;  (ii) any other breach or violation by Genzyme of any
covenant,  agreement,  term or condition of this Agreement or the  Stockholder's
Rights Agreement or in any other document delivered  pursuant hereto;  (iii) any
employment-related  lawsuit,  action,  charge or complaint  overtly  threatened,
brought or filed against Genzyme prior to the date of Closing;  (iv) any grossly
negligent  act or  omission  or  willful  misconduct  of  Genzyme  or  Genzyme's
employees,  agents or independent contractors,  including but not limited to any
act or omission that contributes to (A) any personal injury,  sickness,  disease
or death, (B) any damage to or destruction of any property of R&D or any loss of
use  resulting  therefrom  or (C) any  violation  of any  statute,  ordinance or
regulation;  (v) any  sales or use of the  Genzyme  Products  or  Technology  by
Genzyme  prior to the Closing  (including  any claim of  infringement  for sales
prior to the Closing);  (vi) the  termination or transfer of any employee of the
Business  (other than  employees in the United  Kingdom,  France and Germany) in
connection with the  Transaction;  (vii) any claims arising from the termination
by  Genzyme  of  any of  its  suppliers,  independent  contractors,  dealers  or
distributors  of the  Business in  connection  with the  Transaction,  including
claims of tortious  interference  with  contractual  or business  relations or a
substantially   similar  cause  of  action;   or  (viii)  any  actions,   suits,
proceedings, demands, assessments or judgments incident to any of the foregoing.



     (b) Techne and R&D shall be paid or  reimbursed  the amount  which would be
required  to put them in the  position  that  they  would  have been in had such
representation or warranty been true and correct as of the date made or had such
covenant,  agreement,  term  or  condition  been  performed,  complied  with  or
fulfilled, or had such failure not occurred.

     14.2     Indemnification by R&D and Techne.

     (a) R&D and Techne hereby jointly and severally indemnify Genzyme and agree
to hold  harmless  and, at  Genzyme's  request,  defend  Genzyme  and  Genzyme's
subsidiaries,  and the affiliates,  directors,  officers,  employees, agents and
independent  contractors of each,  against and in respect of any and all Damages
incurred  or suffered by Genzyme as a result of: (i) any breach by R&D or Techne
of any  representation  or  warranty  made by either of them  contained  in this
Agreement  or  the  Stockholder's  Rights  Agreement  or in any  other  document
delivered  pursuant hereto;  (ii) any other breach or violation by R&D or Techne
of  any  covenant,   agreement,   term  or  condition  of  this  Agreement,  the
Stockholder's  Rights Agreement or any other document delivered pursuant hereto;
(iii) any act or  omission  occurring  after the  Closing  with  respect  to the
Business, including without limitation any sale or use of any of the products or
inventories related to the Business, including without limitation the obligation
to assume and discharge the Assumed Liabilities;  (iv) any grossly negligent act
or  omission  or  willful  misconduct  of  R&D  or  R&D,  employees,  agents  or
independent  contractors,  including but not limited to any act or omission that
contributes  to (A) any personal  injury,  sickness,  disease or death,  (B) any
damage to or destruction of any property of Genzyme or any loss of use resulting
therefrom or (C) any violation of any statute,  ordinance or regulation; (v) any
sales or use of the Genzyme  Products or  Technology  subsequent  to the Closing
(including  any claim of  infringement  for sales  subsequent  to the  Closing),
provided that this  subsection  (v) shall not be  interpreted  to prevent R&D or
Techne  from  asserting  a claim  relating  to a breach by  Genzyme of any other
provision  of this  Agreement;  (vi) the  termination  or  transfer of any U.K.,
French or German  employee of the Business in connection  with the  Transaction;
and (vii) any actions,  suits,  proceedings,  demands,  assessments or judgments
incident to any of the foregoing.

     (b) Genzyme shall be paid or reimbursed  the amount which would be required
to  put  Genzyme  in  the  position   that  it  would  have  been  in  had  such
representation or warranty been true and correct as of the date made or had such
covenant,  agreement,  term  or  condition  been  performed,  complied  with  or
fulfilled, or had such act or omission not occurred.




15.  ADDITIONAL AGREEMENTS

     15.1 Incorporation of Schedules and Exhibits.  All schedules,  exhibits and
other  documents and written  information  required to be delivered  pursuant to
this  Agreement are  incorporated  into this Agreement by this reference and are
warranted  by the party or parties  which  deliver the same to be  accurate  and
complete in all material respects.  In the event that any material changes shall
occur with respect to any  information  disclosed  in any schedule  furnished by
either party hereunder  following the date of the delivery  thereof and prior to
the date of Closing, such party shall promptly notify the other party thereof in
writing.

     15.2 Governmental Documents and Financial  Information.  If, after the date
of Closing,  in order properly to prepare its tax returns or other  documents or
reports  required to be filed with  governmental  authorities  or its  financial
statements,  it is necessary  that a party to this  Agreement be furnished  with
additional  information  relating  to the  Assets  and  the  Business  and  such
information  is in  possession  of the other party or any related  party and can
reasonably be furnished to the party in need of such information, then the other
party will, promptly upon request, furnish such information to the party in need
of such  information.  In  furtherance  of this Section 15.2,  Genzyme agrees to
provide to R&D, within forty-five (45) days of Closing: (a) an audited statement
of net assets  transferred  as of  December  31,  1996 and 1997;  (b)  unaudited
statements of net assets  transferred as of the most recent quarter end prior to
the  Closing if the  Closing  occurs on other than a quarter  end;  (c)  audited
statements of revenues,  cost of sales,  gross profit and direct expenses of the
Business for the years ended  December 31, 1995,  1996 and 1997;  (d)  unaudited
statement of revenues,  cost of sales,  gross profit and direct expenses for the
six months  ended June 30,  1998 and for the period from July 1, 1998 to the end
of the quarter (if any) preceding the date of Closing and the  comparable  prior
year period if the Closing occurs on or after June 30, 1998 but before  December
31, 1998; and (e) such other  financial  information  required by the Commission
for  Techne's  Current  Report  of Form 8-K to be filed in  connection  with the
transactions  contemplated  by  this  Agreement  (the  "8-K").  If  the  audited
statement  of  revenues of the  Business  for the year ended  December  31, 1997
reports   revenues  that  are  more  than  ten  percent  (10%)  lower  than  the
corresponding  figure  reported in the  unaudited  statement of revenues for the
year ended December 31, 1997 delivered to R&D pursuant to Section 2.14, then R&D
shall have the right to offset the next Royalty payment due to Genzyme  pursuant
to Section 8.1 by an amount  equal to the product  obtained by  multiplying  (i)
four dollars  ($4.00) and (ii) the difference  between the revenues  reported in
the unaudited  statement of revenues of the Business for the year ended December
31, 1997 and the  corresponding  figure  reported in the  audited  statement  of
revenues  for the year ended  December  31, 1997.  Genzyme  further  agrees that
Techne may use the financial  information  included in the 8-K in future filings
of  registration  statements  and other  reports  as  required  by the rules and
regulations  of the  Commission.  Genzyme  will  use its Best  Efforts  to cause
Coopers & Lybrand  L.L.P.  to provide any required  consents to such filings and
reports at a reasonable cost to Techne.

     15.3 Cooperation.  Each party will take all reasonable actions necessary to
comply  promptly  with all legal  requirements  which may be  imposed on it with
respect to the consummation of the  transactions  contemplated by this Agreement



and will promptly  cooperate with and furnish  information to the other party in
connection with any such requirements  imposed upon either of them in connection
with the consummation of the transactions  contemplated by this Agreement.  Each
party will take all reasonable  actions  necessary to obtain (and will cooperate
with the other party in obtaining) any consent, approval, order or authorization
of, or any  registration,  declaration or filing with, any governmental  entity,
domestic or foreign,  or other  person,  required to be obtained or made by such
party  (or by the other  party)  in  connection  with the  taking of any  action
contemplated by this Agreement.

     15.4 Contract Assignment. Genzyme agrees to use its Best Efforts to obtain,
prior to the date of  Closing,  all such  governmental  and other  consents  and
approvals as may be necessary and  appropriate  in order to enable it to perform
its  obligations  hereunder and to accomplish the transfers to R&D  contemplated
hereby so that R&D may enjoy after the date of  Closing,  (a) all the rights and
benefits,  including,  without  limitation,  the  economic  benefits,  presently
enjoyed by Genzyme in and to the Business and (b) all of Genzyme's right,  title
and  interest in and to each of the Assets.  Genzyme  shall keep R&D apprised of
the status of all  discussions  with third parties in connection  with obtaining
such  consents.  If any consent is not obtained,  or if an attempted  assignment
thereof would be ineffective or would affect the rights of Genzyme thereunder so
that R&D would not in fact receive all such rights,  Genzyme will cooperate with
R&D in any  arrangement  intended to provide for R&D the benefits under any such
contract,  license,  lease,  franchise,  sales order,  purchase  order, or other
agreement,  commitment or arrangement,  including enforcement for the benefit of
R&D of any and all rights of Genzyme under and in any of the foregoing against a
third  party  thereto  arising out of the breach or  cancellation  by such third
party or otherwise. Nothing in this Agreement shall be construed to limit Techne
and R&D's right not to close this transaction as set forth in Section 6.2.

     15.5 Assistance with Audits.  Each party agrees,  if requested by the other
party  at any  time  after  Closing,  to  give  the  requesting  party  and  its
independent  accountants reasonable access to (and to cause reasonable access to
be given by its independent  public  accountants) the workpapers of the party of
whom the  request  was made  pertaining  to the Assets  and/or the  Business  in
connection with the preparation of any financial statements, internal reports or
audits of the  requesting  party,  and to use its Best  Efforts  to  assist  the
requesting  party  and  its  independent   accountants  in  understanding   such
workpapers.

     15.6  Maintenance of Records.  The parties each agree to cooperate fully in
order to allow the maintenance of records  necessary to conduct their respective
businesses  and agree to provide such reports and  information to one another as
are  reasonably  requested  and  reasonably  related  to  the  business  of  the
requesting party or the performance of this Agreement.

     15.7 Product Claims and Returns.  Genzyme shall, for a period of six months
following the Closing,  continue to be responsible  for customer claims relating
to services  rendered  by Genzyme  prior to the date of  Closing,  and  customer
claims  relating  to, or returns  of,  products  of Genzyme  sold and shipped by
Genzyme  prior to the date of  Closing.  If a customer  makes a claim or seeks a
return  after such six month period and, in the  reasonable  judgment of R&D the
claim or return is proper,  R&D may  replace or repair,  as the case may be, the
services  rendered or product  purchased  at R&D, at then  generally  prevailing
prices and labor rates.  Provided  that R&D has  obtained  the prior  consent of
Genzyme,  which  consent  shall  not be  unreasonably  withheld,  Genzyme  shall
reimburse R&D for the cost of such repairs or returns.



     15.8  Adjustments.  To the extent not otherwise  adjusted  pursuant to this
Agreement,  all items and all payments received by Genzyme or by R&D which cover
a period both prior and  subsequent  to the date of Closing  shall be  equitably
prorated as of such date.

     15.9 Taxes.  The  Royalties  do not  include  amounts for taxes that may be
based upon the Technology.  If Genzyme is required to pay sales, use,  property,
transfer,  value-added,  or other  federal,  state or local  taxes  based on the
rights  granted  pursuant to this  Agreement,  the services  provided under this
Agreement,  or on R&D's use of the  Technology  or the Core  Products  then such
taxes  shall be  billed  to and  paid  (or  promptly  reimbursed)  by R&D.  This
provision shall not apply to taxes based on Genzyme's income.

     15.10  Cooperation in  Litigation.  From and after the date of the Closing,
each party shall fully cooperate with the other in the defense or prosecution of
any  litigation  or  proceeding  already  instituted  or which may be instituted
hereafter  against  or by such other  party  relating  to or arising  out of the
conduct  of the  Business  prior  to or  after  the  Closing  Date  (other  than
litigation arising out of the transactions contemplated by this Agreement).  The
party  requesting  such  cooperation  shall  pay  the  reasonable  out-of-pocket
expenses  incurred  in  providing  such  cooperation  (including  legal fees and
disbursements if the requesting party has given prior written consent to the use
by the  other  party of  separate  legal  counsel,  which  consent  shall not be
unreasonably  withheld)  by the  party  providing  such  cooperation  and by its
officers,  directors,  employees and agents,  but shall not be  responsible  for
reimbursing  such party or its  officers,  directors,  employees  and agents for
their time spent in such cooperation.

     15.11  Discount on Sales of R&D  Products  to Genzyme.  For a period of one
year  following  the date of  Closing,  R&D  shall  provide  to  Genzyme  all of
Genzyme's  requirements of Qualified  Products (as defined in Schedule 8.1) at a
twenty-five  percent  (25%)  discount  to the  then-current  list price for such
products.

     15.12  Belgian  Employees. Genzyme will promptly  reimburse  Techne and its
Affiliates  for any costs  incurred by any of them relating to or arising out of
the termination or transfer of any Belgian  employee of the Business  (including
but not  limited to any  payments in lieu of notice of the  Transaction  and any
severance,   termination  or  non-competition  obligations  arising  under  such
employee's  employment  contract or applicable law) following receipt by Genzyme
of a  detailed,  written  report  setting  forth the  costs for which  Techne is
seeking reimbursement.

16.  MISCELLANEOUS

     16.1 Expenses.  Each party shall bear and pay its own expenses  incurred in
connection  with the  transactions  referred  to in this  Agreement.  The  party
responsible  under applicable law shall bear and pay in their entirety all other
registration  and  transfer  fees,  if any,  payable  by  reason of the sale and
conveyance of the Assets. Each party will cooperate to the extent practicable in
minimizing  all taxes and fees levied by reason of the sale or assignment of the
Assets.



     16.2 Public Announcements.  Each party will be responsible for the issuance
of press  releases  or trade  releases,  and the  making  of such  other  public
statements  with respect to this  Agreement  and the  transactions  contemplated
hereby as may, in such party's reasonable judgment, be necessary or appropriate;
provided, however, that any such release or statement which contains the name of
the other party shall be subject to the reasonable approval of such other party.
In carrying out this  responsibility,  a party proposing to issue such a release
or make such a statement shall provide the other party with at least forty-eight
(48) hours notice by telefax of any proposed  press  release,  trade  release or
public  statement.  Notwithstanding  the  foregoing,  the  parties  agree to the
issuance of a joint press release  announcing  the execution of this  Agreement,
such press release to be in such form and issued at such time as the parties may
mutually agree.

     16.3 Term and Termination.

     (a) This Agreement may be terminated before the Closing as follows:

          (i) at the election of Genzyme  upon written  notice to Techne and R&D
     if, on or after August 31, 1998,  any one or more of the  conditions to the
     obligation of Genzyme to close has not been fulfilled;

          (ii) at the election of Techne and R&D upon written  notice to Genzyme
     if, on or after August 31, 1998,  any one or more of the  conditions to the
     obligation of Techne and R&D to close has not been fulfilled;

          (iii) at the election of Genzyme upon written notice to Techne and R&D
     if Techne or R&D has breached  any  representation,  warranty,  covenant or
     agreement contained in this Agreement and has not, within ten (10) business
     days after receipt by Techne or R&D, as the case may be, of written  notice
     of such breach of representation,  warranty,  covenant or agreement,  cured
     such breach;

          (iv) at the election of Techne and R&D upon written  notice to Genzyme
     if Genzyme has breached any representation, warranty, covenant or agreement
     contained in this  Agreement  and has not,  within ten (10)  business  days
     after   receipt  by  Genzyme   of   written   notice  of  such   breach  of
     representation, warranty, covenant or agreement, cured such breach; or

          (v) by mutual written agreement of Genzyme, Techne and R&D.

     (b) This Agreement is subject to termination after the Closing as follows:

          (i) Either Genzyme or R&D shall have the right to terminate Article 10
     of this Agreement, without prejudice to any other right or available remedy
     


     or relief,  immediately upon written notice to the other at any time if the
     other party: (i) becomes insolvent;  (ii) fails to pay its debts or perform
     its  obligations in the ordinary  course of business as they mature;  (iii)
     admits in writing its  insolvency  or inability to pay its debts or perform
     its  obligations as they mature;  (iv) makes and assignment for the benefit
     of creditors;  or (v) commences or has commenced against it a bankruptcy or
     similar proceeding; or

          (ii) This  Agreement  shall  terminate  if and as  specified by mutual
     written agreement of the Parties.

     (c) If this Agreement is terminated:

          (i)  before  the  Closing  pursuant  to  Section   16.3(a),   and  the
     transactions  contemplated  hereby are not  consummated as provided  above,
     each and every  representation  and warranty contained in this Agreement or
     any  Schedule  hereto,  or any  certificate,  document or other  instrument
     delivered by the parties in connection therewith,  shall expire and none of
     the parties hereto shall be under any liability  whatsoever with respect to
     any   such   representation   or   warranty;    provided,   however,   that
     notwithstanding the foregoing, each party shall be and remain liable to the
     other in the event that the  failure to close  hereunder  shall  occur as a
     consequence  of the failure of a party to fully  perform its  covenants and
     agreements   hereunder   or  the   material   breach  by  a  party  of  its
     representations or warranties contained herein;

          (ii)  after  the  Closing  pursuant  to  Section  16.3(b),  except  as
     otherwise  agreed,  all  provisions,  terms and  conditions  shall  survive
     termination other than the provisions of Articles 9 and 10; and

          (iii) in either case,  the  provisions of Article 11 shall continue to
     apply for a period of three (3) years from the date of termination.

     16.4 Entire Agreement; Modifications; Waiver. This Agreement, together with
the  related  agreements,  Schedules  referenced  herein  and  Exhibits  hereto,
constitutes the final,  exclusive and complete understanding of the parties with
respect  to  the  subject  matter  hereof  and  supersedes  any  and  all  prior
agreements, understandings and discussions with respect thereto. No variation or
modification  of this  Agreement  and no waiver of any  provision  or  condition
hereof, or granting of any consent contemplated hereby, shall be valid unless in
writing and signed by the party against whom  enforcement of any such variation,
modification, waiver or consent is sought.

     16.5 Survival of Representations  and Warranties.  All  representations and
warranties  made by any party to this Agreement or pursuant hereto shall survive
the closing of the transactions hereunder;  provided,  however, that except with
respect to warranties  of title to the Assets or to the absence of  encumbrances
on the  Assets,  notice of any claim  based on a breach of a  representation  or



warranty  must be given  within one (1) year from the date of Closing or, in the
case of representations  or warranties dealing with tax matters,  within one (1)
year plus sixty (60) days after the  expiration of the applicable tax statute of
limitations.  The representations and warranties hereunder shall not be affected
or diminished by any  investigation at any time by or on behalf of the party for
whose benefit such  representations  and  warranties  were made.  All statements
contained  herein  or in any  schedule,  exhibit,  certificate,  list  or  other
document  delivered  pursuant  hereto  or in  connection  with the  transactions
contemplated hereby shall be deemed to be representations and warranties.

     16.6 Further  Assurances.  The parties hereto shall use their best efforts,
and  shall  cooperate  with one  another,  to  secure  all  necessary  consents,
approvals, authorizations, exemptions and waivers from third parties as shall be
required in order to consummate the transactions  contemplated hereby, and shall
otherwise use their best efforts to cause such transactions to be consummated in
accordance  with the terms and  conditions  hereof.  At any time or from time to
time after the  Closing,  each party hereto  shall,  at the request of the other
party,  execute and deliver any further  instruments  or documents  and take all
such further action as the requesting  party may reasonably  request in order to
consummate and document the transactions contemplated hereby.

     16.7 Captions.  The captions in this Agreement are for convenience only and
shall not be considered a part of or affect the  constructing or  interpretation
of any provision of this Agreement.

     16.8  Counterparts.  This  Agreement  may  be  executed  in any  number  of
counterparts,  each of which when so executed shall  constitute an original copy
hereof, but all of which together shall constitute one agreement.

     16.9 Successors and Assigns. This Agreement shall be binding upon and inure
to the  benefit  of the  parties  to this  Agreement  and their  successors  and
assigns,  provided that,  except as otherwise  provided  herein,  the rights and
obligations  of any party to this  Agreement  may not be  assigned  without  the
written  consent of the other  party,  which  consent  will not be  unreasonably
withheld. Any party, however, may assign its rights and obligations to an entity
succeeding to substantially all of its assets and business.

     16.10 Parties in Interest.  Nothing in this  Agreement,  whether express or
implied, is intended to confer any rights or remedies under or by reason of this
Agreement  on any  persons  other than the  parties  to it and their  respective
successors and assigns, nor is anything in this Agreement intended to relieve or
discharge the  obligation or liability of any third persons to any party to this
Agreement,  nor  shall  any  provision  give  any  third  persons  any  right of
subrogation or action over against any party to this Agreement.

     16.11  Notices.  All notices,  requests,  demands and other  communications
hereunder  ("Notices") shall be in writing and shall be deemed to have been duly
given if delivered by hand or by registered or certified mail,  postage prepaid,
return  receipt  requested,  but only upon  receipt of such return  receipt,  as
follows:



         if to Genzyme,

                           Genzyme Corporation
                           One Kendall Square
                           Cambridge, Massachusetts 02139
                           Attn:    Chief Legal Officer
                           Tel:     617-252-7500
                           Fax:     617-252-7600

         with a copy to,

                           Maureen P. Manning
                           Palmer & Dodge LLP
                           One Beacon Street
                           Boston, Massachusetts 02108
                           Tel:   (617) 573-0100
                           Fax:   (617) 227-4420

         if to R&D,

                           Research and Diagnostic Systems, Inc.
                           614 McKinley Place
                           Minneapolis, Minnesota 55413
                           Attn:    Thomas E. Oland
                           Tel:     (612) 379-2956
                           Fax:     (612) 379-6580

         with a copy to,

                           Fredrikson & Byron, P.A.
                           1100 International Centre
                           900 Second Avenue South
                           Minneapolis, MN 55402
                           Attn:    Timothy M. Heaney
                           Tel:     (612) 347-7019
                           Fax:     (612) 347-7077

         if to Techne,

                           Techne Corporation
                           614 McKinley Place
                           Minneapolis, Minnesota 55413
                           Attn:    President
                           Tel:     (612) 379-2956
                           Fax:     (612) 379-6580



         with a copy to,

                           Fredrikson & Byron
                           1100 International Centre
                           900 Second Avenue South
                           Minneapolis, MN 55402
                           Attn:    Timothy M. Heaney
                           Tel:     (612) 347-7019
                           Fax:     (612) 347-7077

or to such  other  address  as any party  may have  furnished  to the  others in
writing in accordance  herewith,  except that notices of change of address shall
only be effective upon receipt. All Notices shall be deemed received on the date
of delivery or, if mailed, on the date appearing on the return receipt therefor.

     16.12 Law Governing. This Agreement shall be governed by, and construed and
enforced in accordance  with the laws of the State of Minnesota,  without regard
to its choice-of-laws or conflicts-of-law rules.





IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be duly
executed, all as of the day and year first above written.

GENZYME:                       GENZYME CORPORATION


                               By: /s/ David D. Fleming
                                   David D. Fleming, Group Senior Vice President


R&D:                           RESEARCH AND DIAGNOSTIC SYSTEMS, INC.


                               By:  /s/ Thomas E. Oland
                                    Thomas E. Oland, President


TECHNE:                        TECHNE CORPORATION


                               By:  /s/ Thomas E. Oland
                                    Thomas E. Oland, President