Exhibit 3.1.3

                           CERTIFICATE OF AMENDMENT OF
                         CERTIFICATE OF INCORPORATION OF
                           UNIGENE LABORATORIES, INC.


     UNIGENE LABORATORIES,  INC., a corporation organized and existing under and
by virtue of the General  Corporation Law of the State of Delaware,  DOES HEREBY
CERTIFY:

     FIRST:  That the Board of Directors  of Unigene  Laboratories,  Inc.,  at a
meeting duly held by unanimous  vote of its members,  recorded in the Minutes of
the Board, duly adopted  resolutions  setting forth a proposed  Amendment to the
Certificate of Incorporation of said Corporation, declaring said Amendment to be
advisable  and calling a meeting of the  stockholders  of said  Corporation  for
consideration thereof. The resolution setting forth the proposed Amendment is as
follows:

     RESOLVED,  that the Board of Directors hereby declares that it is advisable
     to increase the number of shares of Common Stock authorized for issuance by
     amending Article FOURTH of the  Corporation's  Certificate of Incorporation
     to read as follows:

          "FOURTH:  The total  number of shares of stock  which the  Corporation
          shall have  authority to issue is one hundred  million  (100,000,000),
          having a par value of $.01 per share. All such shares are of one class
          and are common stock."

     SECOND: That thereafter,  pursuant to resolution of its Board of Directors,
an annual meeting of the  stockholders  of said  Corporation was duly called and
held, upon notice in accordance with Section 222 of the General  Corporation Law
of the State of Delaware,  at which  meeting the  necessary  number of shares as
required by statute were voted in favor of the Amendment.

     THIRD:  That  said  Amendment  was  duly  adopted  in  accordance  with the
provisions  of  Section  242 of the  General  Corporation  Law of the  State  of
Delaware.

     IN WITNESS  WHEREOF,  said  Unigene  Laboratories,  Inc.  has  caused  this
Certificate  to be signed by Warren P. Levy,  its  President,  and  attested  by
Ronald S. Levy, its Secretary, this 18th day of July, 2001.


                                           UNIGENE LABORATORIES, INC.

                                           By  /s/ Warren P. Levy
                                             -------------------------
                                             Warren P. Levy, President



ATTEST:

/s/ Ronald S. Levy
- -------------------------
Ronald S. Levy, Secretary