EXHIBIT 10.19

                                 EXECUTION COPY










                              AMENDED AND RESTATED

                         SECURITIES PURCHASE AGREEMENT

                                  by and among

                            OLYMPUS SECURITIES, LTD.
                                      and
                                NELSON PARTNERS
                               (the "Purchasers")

                                      and

                           UNIGENE LABORATORIES, INC.
                                  ("Unigene")




                           Dated as of March 6, 1996

                                

                              AMENDED AND RESTATED
                          SECURITIES PURCHASE AGREEMENT

                  AMENDED AND RESTATED SECURITIES PURCHASE AGREEMENT dated as of
March 6, 1996  (the  "Agreement"),  by and among  OLYMPUS  SECURITIES,  LTD.,  a
Bermuda  international  business company  ("Olympus"),  and NELSON  PARTNERS,  a
Bermuda general partnership  ("Nelson")  (collectively,  the "Purchasers"),  and
UNIGENE  LABORATORIES,  INC., a Delaware  corporation  with a principal place of
business at 110 Little Falls Road, Fairfield, New Jersey 07004 ("Unigene").


                                 R E C I T A L:
                                 - - - - - - -

         A. Unigene is engaged  principally  in research and  development in the
field of biotechnology and plans to commence manufacturing peptide hormones. Its
common stock is currently traded on the NASDAQ market.

         B. Purchasers are private investment companies.

         C.  Pursuant  to  a  certain  Assignment   Agreement  (the  "Assignment
Agreement")  dated  November 17,  1995,  among the  Purchasers,  Unigene and The
Microcap Fund,  Inc. (the "Fund"),  the Purchasers  have acquired from the Fund:
(i) all rights of the Fund in the Note dated May 8, 1995 (the  "Original  Note")
with an original principal amount of $2,000,000 (the "Initial Principal Amount")
plus  accrued  and  unpaid  interest  through  such date in an  amount  equal to
$221,330  (the  "Initial  Accrued  Interest");  (ii) all  rights  of the Fund in
225,000 warrants (the "Purchased Warrants"),  expiring July 7, 2000, to purchase
Unigene's  Common  Stock  (the  "Common  Stock")  at a price of $1.375 per share
(subject  to  certain  anti-dilution  provisions);  (iii) all rights of the Fund
under that certain Securities  Purchase Agreement dated as of May 8, 1995 by and
between the Fund and Unigene (the "Original Agreement"),  including the Original
Note and the Documents as defined therein (the "Original  Documents");  and (iv)
all security interests,  liens and collateral  assignment  interests of the Fund
arising under and with respect to the Original  Documents and securing Unigene's
obligations  evidenced by or arising  under or in  connection  with the Original
Agreement and Original Note (such obligations  being hereinafter  referred to as
the "Original Obligations").

         D.  The  Purchasers  entered  into  the  transaction  described  in the
foregoing  recital  solely as an  accommodation  to  Unigene  (and with the full
knowledge and consent of Unigene),  and as an interim step toward receiving from
Unigene  certain  Senior  Secured  Convertible  Debentures  and an amendment and
restatement of the Original Agreement in its entirety.

         E. The  Purchasers  and  Unigene  entered  into a  Securities  Issuance
Commitment  Agreement  dated  November  17, 1995 (the  "Commitment"),  which (i)
provided for the  Purchasers to lend  $778,670 to Unigene (the "Initial  Interim
Loan") and (ii) set forth the parties'  mutual  intention  that Unigene issue to
the  Purchasers  the  aforesaid  Senior  Secured  Convertible  Debentures in the
aggregate  principal  amount of $3,000,000  to  substitute,  amend,  restate and
re-evidence  (but not as a novation or refinancing of) the Original  Obligations
(including the Initial  Principal  Amount and the Initial  Accrued  Interest) as
well as to evidence the Initial Interim Loan.

         F. On or about December 21, 1995,  the Purchasers  loaned an additional
$300,000 to Unigene (the "Second  Interim  Loan"),  and the parties  desire that
Unigene issue and the Purchasers receive  additional Senior Secured  Convertible
Debentures,  of the same tenor as, but of  different  date than,  the  aforesaid
Senior Secured  Convertible  Debentures,  in said $300,000  principal  amount to
re-evidence and restate the Second Interim Loan.

         G.  Unigene  has hereby  agreed to enter into an Amended  and  Restated
Security  Agreement,  an Amended and Restated Trademark Security  Agreement,  an
Amended and Restated Patent Security Agreement, a Leasehold Mortgage, an Amended
and Restated  Collateral  Assignment of License  Rights, an Amended and Restated
Mortgage  and  Security  Agreement,  and an  Amended  and  Restated  Lender  and
Mortgagee's  Consent and Waiver,  in each case among  Unigene and various  other
parties and certain other security documents.

         H.  Unigene  now  proposes  to issue  and sell to  Purchasers,  and the
Purchasers desire to purchase, two 9.5% Senior Secured Convertible Debentures in
the principal  amounts of $3,000,000  (Debenture A) and $300,000  (Debenture B),
respectively,  and on the terms and  conditions  hereinafter  set forth -- which
modify the terms of the Commitment in certain respects -- the Debentures to bear
interest from November 17, 1995  ($3,000,000)  and December 21, 1995 ($300,000),
respectively, but to otherwise be of like and similar tenor.

         I.  Unigene and the  Purchasers  agree that,  effective  as of the date
hereof,  (i) the  Original  Agreement,  Original  Note  and  any  and all  other
agreements and understandings  governing the terms of repayment of or evidencing
the Original  Obligations,  the Initial Interim Loan and the Second Interim Loan
shall be hereby  amended and restated in their entirety by this Agreement and by
the issuance of "Debenture A" and  "Debenture B" referred to and defined  below.
It is the  intention of the parties  hereto that the  execution  and delivery of
this Agreement and the issuance of such Debentures hereby not effect a novation,
payment,  discharge or  extinguishment of any of the Original  Obligations,  the
Initial  Interim  Loan or the  Second  Interim  Loan,  but merely  constitute  a
restatement and substitution of the terms of their repayment and security.

         J. The Purchasers  hereby  acknowledge and agree that as of the date of
hereof  Unigene is not, and has not been,  in default  under the Original  Note,
Debenture A or Debenture B, as  applicable,  by reason of the  occurrence of the
existing Maturity Date (as defined in the Original Note).

                  NOW, THEREFORE, the parties hereto agree as follows:

                  1.       Definitions

                           1.1 Definitions.  For purposes hereof,  the following
terms have the following meanings:

                               1.1.1 "Affiliate" shall have the meaning ascribed
to such term in Rule 405 promulgated under the Securities Act.

                               1.1.2  "Assignees'   Rights"  means  all  of  the
rights,  title and interest of the Fund under the Original Documents (other than
the  warrants  retained  by the  Fund)  subsequently  sold and  assigned  to the
Purchasers under the terms of the Assignment Agreement.

                               1.1.3 "Associate" shall have the meaning ascribed
to such term in Rule 405 promulgated under the Securities Act.

                               1.1.4 "cGMP" means that  Unigene's  Boonton,  New
Jersey  facility has achieved a status  sufficient  to allow  Unigene to conduct
Phase III (clinical) pivotal trials with the calcitonin produced therein.

                               1.1.5  "Claim"  refers  to any and  all  actions,
causes of action, suits, liabilities, dues, sums of money, accounts, reckonings,
bonds,  bills,  covenants,  contracts,   controversies,   agreements,  promises,
variances,  trespasses, damages, judgments,  executions, and demands whatsoever,
in law or equity.

                               1.1.6   "DEA"   means  the  United   States  Drug
Enforcement Administration.

                               1.1.7   "Encumbrance"  means  any  title  defect,
conflicting  claim  of  ownership,   order,   decree,   judgment,   stipulation,
settlement,  attachment,  restriction,  lien,  pledge,  right of first  refusal,
option,  security  interest,  mortgage,  covenant,  or any other  encumbrance on
Unigene's  right to  transfer  the  "Collateral"  (as defined in the Amended and
Restated  Security  Agreement  (the  "Security  Agreement")  to be executed  and
delivered  by  Unigene in  connection  with this  Agreement  or any of its other
property  other than (i) liens for  taxes,  assessments  and other  governmental
charges or levies not due and payable or which are currently  being contested in
good faith by appropriate proceedings,  and have been adequately reserved for in
the   Financial   Statements,   (ii)   mechanics',    workmen's,    repairmen's,
materialmen's, warehousemen's, vendors', and carriers', liens, and other similar
liens  arising in the  ordinary  course of business  for  charges  which are not
delinquent,   or  which  are  being  contested  in  good  faith  by  appropriate
proceedings  and have not  proceeded  to  judgment,  and  have  been  adequately
reserved  for, and (iii) liens in respect of judgments or awards with respect to
which  there  shall  be a  good  faith  current  prosecution  of  an  appeal  or
proceedings  for review  which is secured  by an  appropriate  bond or a stay of
execution  pending  such  appeal or  proceedings  for review and which have been
adequately reserved for.

                               1.1.8 "FDA" means the United States Food and Drug
Administration.

                               1.1.9  "Financial   Statements"   means  the  (i)
financial  statements  of Unigene as  contained  in its Form 10-K for its fiscal
year ended December 31, 1994, (ii) financial  statements of Unigene as contained
in its Form  10-Q  for its  fiscal  quarter  ended  September  30,  1995,  (iii)
unaudited  balance sheet of Unigene as of November 30, 1995 and, (iv)  unaudited
statements of  operations,  cash flows and  shareholders'  equity for the months
ended October 31 and November 30, 1995.

                               1.1.10   "Funding   Event"  means  (i)  Strategic
Partner or other corporate partner financing (only that portion received in cash
upfront or to be received in substantially  equal  installments over a period of
no more than 12 months),  (ii) the  issuance of Common  Stock,  (iii)  Preferred
Stock  with an  average  life of no less than two  years,  (iv) debt  securities
(including  term bank loans)  with a maturity of no less than two years,  or (v)
any  other  non-refundable  investments  made  by  third  parties.  For  greater
certainty  and not by way of  limitation,  the sale of the  Unigene  convertible
debentures  pursuant to the Regulation S offering managed by Swartz  Investments
LLC shall constitute a "Funding Event."

                               1.1.11 "GAAP" means Generally Accepted Accounting
Principles as in effect from time to time in the United States.

                               1.1.12 "Intellectual  Property" means Copyrights,
Patent Rights, Trademarks and Trade Secrets. For purposes of this Agreement, (i)
"Copyrights" means United States and foreign  copyrights,  whether registered or
unregistered,  and pending  applications  to  register  the same;  (ii)  "Patent
Rights"  means  United  States  and  foreign   patents,   patent   applications,
continuations, continuations-in-part, divisions, reissues, patent disclosures or
improvements thereto;  (iii) "Trademarks" means United States, state and foreign
trademarks,   service  marks,  logos,  trade  dress  and  trade  names,  whether
registered or unregistered,  and pending applications to register the foregoing;
and (iv) "Trade  Secrets"  shall have the meaning of the term "trade  secret" as
such term is defined in the Illinois  Trade  Secrets Act, 765 ILCS 1605 et seq.,
any amendments thereto and any successor statute thereto.

                               1.1.13  "Market  Value" of the Common  Stock on a
given day shall mean the average bid price on the Common  Stock on the NASDAQ or
a  national  securities  exchange,  as  applicable,  for  the ten  trading  days
immediately preceding the date for which the Market Value is being calculated.

                               1.1.14 "Net  Proceeds"  means the gross  proceeds
received by Unigene from any Funding  Events minus any banker's,  underwriter's,
finder's, accountant's, printer's, filing, legal and other transaction expenses.

                               1.1.15 "Permits" means permits, licenses, orders,
authorizations,  certification  or  approvals of any  federal,  state,  local or
foreign governmental or regulatory body, including,  without limitation, the DEA
and the FDA.

                               1.1.16. "Permitted Liens" means:

                           (a) the liens  arising  under this  Agreement  or the
         Documents in favor of the Purchasers;

                           (b) with  respect to any Person,  liens for taxes not
         yet due and  payable  or which are  being  contested  in good  faith by
         appropriate  proceedings  diligently  pursued;  provided  that  (i) any
         proceedings commenced for the enforcement of such liens shall have been
         duly  suspended  and (ii) full  provision  for the  payment of all such
         taxes known to such Person has been made on the books of such Person if
         and to the extent required by GAAP; and provided  further that no liens
         arising under the Employee  Retirement  Income Security Act, as amended
         ("ERISA"),  or relating to  environmental  obligations  or  liabilities
         shall be deemed "Permitted Liens";

                           (c)  with   respect   to  any   Person,   mechanics',
         materialmen's,  carriers',  warehousemen's and similar liens arising by
         operation  of law and in the  ordinary  course of business and securing
         obligations  of such  Person that are not yet  delinquent  or are being
         contested in good faith by appropriate  proceedings diligently pursued,
         provided  that in the  case of any  such  contest  (i) any  proceedings
         commenced  for the  enforcement  of such  liens  shall  have  been duly
         suspended and (ii) full provision of the payment of such liens has been
         made on the books of such Person if and to the extent required by GAAP;

                           (d) with  respect  to any  Person,  liens  arising in
         connection with worker's compensation,  unemployment insurance, old age
         pensions and social  security  benefits and deposits in connection with
         self-insurance  arrangements,  in each case that are not overdue or are
         being  contested in good faith by  appropriate  proceedings  diligently
         pursued,  provided  that  in the  case  of any  such  contest  (i)  any
         proceeding  commenced for the enforcement of such liens shall have been
         duly  suspended,  and (ii) full provision for the payment of such liens
         has been made on the books of such Person if and to the extent required
         by GAAP;

                           (e) with  respect to any  Person,  liens  incurred or
         deposits  made  in the  ordinary  course  of  business  to  secure  the
         performance of bids, tenders,  statutory  obligations,  trade contracts
         (exclusive of obligations  incurred in connection with the borrowing of
         money or the  payment  of the  deferred  purchase  price of  property),
         surety,  indemnity,  performance,  appeal and  release  bonds and other
         obligations  of a like  nature  incurred  in  the  ordinary  course  of
         business,  provided  that full  provision  for the  payment of all such
         obligations  has been  made on the  books of such  Person if and to the
         extent required by GAAP;

                           (f) imperfections of title, covenants,  restrictions,
         easements and other encumbrances on real property that (i) do not arise
         out of the incurrence of any  indebtedness  for money borrowed and (ii)
         do not  interfere  with or impair in any material  respect the utility,
         operation,  value or  marketability  of the real property on which such
         lien is imposed;

                           (g) liens securing indebtedness in respect of capital
         leases,  provided  that no such  lien  shall  extend  to or  cover  any
         property of such Person other than the respective  property financed by
         such  indebtedness  and the principal  amount of  indebtedness  secured
         thereby is not increased; and

                           (h)  liens  which  are in  existence  as of the  date
         hereof,  including  extensions and renewals  thereof,  provided that no
         such lien covers any  additional  property and the principal  amount of
         indebtedness secured thereby is not increased.

                               1.1.17 "Person" means an individual, partnership,
corporation, trust, unincorporated organization, government or any department or
agency thereof and any other entity.

                               1.1.18  "Securities Act" means the Securities Act
of 1933, as amended.

                               1.1.19 "Strategic Partner" means any Person which
has entered into an agreement  with Unigene which  provides (a) that such Person
will  arrange for  marketing,  manufacturing  and/or  distribution  services for
Unigene's  amidated peptide products  developed  and/or  manufactured  utilizing
Unigene's  proprietary  technology  and (b) that such Person or entity will,  at
Unigene's option, either (1) make an aggregate payment of at least $2,000,000 to
Unigene in up-front fees and/or scheduled, already known fixed payments over the
term of the agreement or (2) if the marketing territory covered by the agreement
includes the United States, Japan, or European countries, pay Unigene at least a
5% royalty over the term of the agreement.

                           1.2 Accounting  Terms.  Any accounting  terms used in
this Agreement shall, unless otherwise specifically provided,  have the meanings
customarily given them in accordance with GAAP.

                  2. Issuance of Debentures and Warrants.

                           2.1      Closing.

                           (a) On the date hereof,  the  Purchasers  and Unigene
         having as of such time and date executed and delivered this  Agreement,
         Unigene shall deliver to the Purchasers the Senior Secured  Convertible
         Debentures  in  the  aggregate  principal  amount  of  $3,300,000  duly
         executed by Unigene, in the forms of Exhibit A and Exhibit B hereto.

                           (b) This Agreement is being executed and delivered on
         March 6, 1996. On or before the end of the fifth business day after the
         date  hereof,  Unigene  will  deliver  or  cause  to  be  delivered  to
         Purchaser:

                           (i)  an Amended and Restated Security Agreement;

                           (ii)  certain  amended  and  restated   Subordination
                           Agreements;

                           (iii) an  amended  and  restated  first  mortgage  on
                           Unigene's  real property  located at 110 Little Falls
                           Road, Fairfield, New Jersey 07004 (the "Mortgage");

                           (iv)  certain  UCC  financing  statements  and  UCC-3
                           statements of assignment executed by Unigene;

                           (v) Amended and Restated  Patent  Security  Agreement
                           and  Trademark   Security   Agreements   and  related
                           documents; and

                           (vi) Amended and Restated  Collateral  Assignment  of
                           License Agreements.

                           Failure  timely to deliver the foregoing  shall cause
         Unigene  forthwith  to be in default  under this  Agreement  as well as
         under the Debentures.

                           Unigene  shall use best  efforts to cause  Mrs.  Jean
         Levy to execute and deliver certain amended and restated  Subordination
         Agreements  on or before the fifth  business day after the date hereof,
         but shall only be deemed in default (as  contemplated  by the preceding
         paragraph) if the  agreements  referred to in (ii) are not delivered by
         March 31, 1996.

                           Unigene  shall also use best efforts to (i) cause the
         Fund to execute  and  deliver the UCC  financing  statements  and UCC-3
         statements of assignment  set forth in clause (iv) above,  (ii) deliver
         to the Purchaser a Leasehold  Mortgage with respect to Unigene's rights
         under its lease of the premises  located at 83 Fulton Street,  Boonton,
         New  Jersey,  together  with  an  Amended  and  Restated  Landlord  and
         Mortgage's   Consent  and  Waiver,   (iii)  certain  UCC-3  termination
         statements and subordination agreements,  and such other instruments of
         similar  effect,  duly  executed  by any party  (other than the parties
         hereto,  and including  specifically  and without  limitation  the Levy
         Family)  that  has a lien  or  security  interest  in any of  Unigene's
         assets, (iv) title insurance regarding the real property located at 110
         Little Falls Road,  Fairfield,  New Jersey 07004, and (v) a lien search
         report  regarding  the  real  property  located  at 83  Fulton  Street,
         Boonton,  New Jersey.  Failure to deliver the  documents  identified in
         clauses (i) through (v) in the  immediately  preceding  sentence  shall
         not,  however,  in the  absence  of bad  faith,  constitute  a  default
         hereunder or under the Debentures.

                           (b) As of  the  date  hereof,  the  Purchasers  shall
         transfer  to Unigene  the  Original  Note,  after  first  affixing  the
         following legend thereto:

                           "The  indebtedness  evidenced by this promissory note
                           (as well as  certain  other  indebtedness  for  money
                           borrowed) has been  re-evidenced  and  substituted by
                           that  certain  Debenture  A dated  November  17, 1995
                           executed by Unigene  Laboratories,  Inc.,  a Delaware
                           corporation   ("Unigene"),   and  made   payable   to
                           Purchasers  pursuant  to  that  certain  Amended  and
                           Restated  Securities  Purchase  Agreement dated as of
                           March 6, 1996 among Unigene and such Purchasers. Such
                           substitution   did  not  constitute  a  repayment  or
                           novation  of  the  indebtedness   evidenced  by  this
                           promissory note."

                           (c)  Unigene  shall use best  efforts  to  deliver to
         Purchasers  the favorable  opinions of counsel to Unigene,  in form and
         substance  satisfactory to the Purchasers and substantially  similar to
         those  opinions  delivered in connection  with the Original  Documents.
         Failure to deliver such opinions shall not, however,  in the absence of
         bad  faith,  constitute  a default  under this  Agreement  or under the
         Debentures.

                           2.2  Terms of Debentures.  Unigene shall issue to the
Purchasers two Senior Secured Convertible  Debentures having the terms described
in this  Agreement.  Debenture  A shall be  issued  in the  principal  amount of
$3,000,000 -- relating to the amounts due to Purchasers  based upon the November
17, 1995  transactions  described above  ("Debenture  A").  Debenture B shall be
issued in the  principal  amount of  $300,000  -- relating to the amounts due to
Purchasers  based  upon  the  December  21,  1995  transaction  described  above
("Debenture B"). Collectively,  Debenture A and Debenture B shall be referred to
herein as the "Debentures".

                               2.2.1 Maturity  Date.  The  Debentures  shall all
mature on  November  15,  1998 (the  "Maturity  Date").  Debenture  A shall bear
interest  from  November  17,  1995 and  Debenture  B from  December  21,  1995.
Debenture  A shall be dated  November  17,  1995 and  Debenture B shall be dated
December 21, 1995.

                               2.2.2  Principal  and  Interest.  Interest  shall
accrue on each  Debenture  at the rate of nine and one-half  percent  (9.5%) per
annum, from the date of each Debenture (not the date hereof) until all principal
and interest due on such Debenture are paid in full.  Interest on the Debentures
shall be paid in cash  semi-annually,  on May 15 and  November  15 of each  year
(each an "Interest  Payment Date")  commencing  May 15, 1996.  Interest shall be
calculated on the basis of a 360-day year of 12 30-day months.

                               Payment of the  principal  of and interest on the
Debentures  shall be made by  Unigene  to the  Purchasers  by wire  transfer  of
immediately available funds.

                               2.2.3 Conversion.

                           (a) The Debentures are convertible into Common Stock,
         at any time and from  time to time,  through  the  Maturity  Date.  The
         Debentures  are  initially  convertible  at a price per share  equal to
         $1.15, subject to the following adjustments (the "Conversion Price").


                           (b) On April 1, 1996,  July 1, 1996,  and  thereafter
         annually on July 1 of each subsequent  year (each a "Reset Date"),  the
         Conversion  Price  shall be reset  to the  lower of (i) the  Conversion
         Price  then in effect,  or (ii) 85% of the  Market  Value of the Common
         Stock.

                           (c) In the event that during the Registration  Period
         (as hereinafter defined) an effective  registration  statement covering
         the public resale of the Common Stock  issuable upon  conversion of the
         Debentures  is not in effect  for more than  five  (non-consecutive  or
         consecutive)  months,  the  Conversion  Price  then  in  effect  on the
         Debentures shall be reduced by 5% each.  Subsequent 5% Conversion Price
         reductions shall occur if such registration  statement is not in effect
         as  of  more  than  ten,  fifteen,  twenty,  etc.  (non-consecutive  or
         consecutive)  month-ends during the Registration  Period.  Once reduced
         under  the  preceding  sentence,  the  Conversion  Price  shall  not be
         adjusted  back,   regardless  of  any  future  effective   registration
         statements.

                               2.2.4 Anti-Dilution.

                           (a)  Effectiveness.   The  anti-dilution   provisions
         described in this Section 2.2.4 shall be effective with respect to each
         Debenture  from  such  Debenture's  date of  issuance  until  each such
         Debenture is paid in full,  including  all  principal  and interest due
         thereon, in accordance with the terms thereof.

                           (b)  Computation of Adjusted  Conversion  Price.  The
         Conversion  Price of the Debentures  shall be adjusted  proportionately
         downward  as  provided  in this  Section  2.2.4(b),  in the event  that
         Unigene issues,  other than pursuant to the exercise or conversion of a
         Convertible Security (as hereinafter  defined),  or sells any shares of
         its Common Stock  (including  shares held in Unigene's  treasury) for a
         price  below the  higher of the  then-current  Conversion  Price or the
         then-current Market Value of the Common Stock.  Forthwith upon any such
         issuance or sale,  the  Conversion  Price shall be reduced to the price
         calculated  by  multiplying  the  Conversion  Price by a fraction,  the

         numerator  of which  shall be the sum of (a) the  number  of  shares of
         Common  Stock  outstanding  prior to the  issuance  on a  fully-diluted
         basis,  plus (b) the  number  of  shares  of  Common  Stock  which  the
         aggregate cash consideration  received by the Company for such issuance
         would have purchased at the higher of the then-current  Market Value or
         the then-current  Conversion  Price, and the denominator of which shall
         be the  number  of  shares  of  Common  Stock  outstanding  immediately
         following such issuance on a fully-diluted basis.

                           (c) Options,  Rights,  Warrants and  Convertible  and
         Exchangeable  Securities.  Except with  respect to rights  described in
         Section  2.2.4(i),  if  Unigene  issues  or sells  options,  rights  or
         warrants  to  subscribe  for  shares of  Common  Stock,  or issues  any
         securities or instruments  convertible  into or exchangeable for shares
         of Common Stock  (collectively,  the "Convertible  Securities"),  which
         Convertible  Securities have an exercise,  conversion or exchange price
         (in the case of  warrants  or  options,  when added to the amount  paid
         therefor) below the higher of the then-current  Conversion Price or the
         then-current  Market Value of the Common Stock, the Conversion Price in
         effect immediately prior to the issuance of such Convertible Securities
         shall be  reduced  to a price  determined  by making a  computation  in
         accordance  with  the  provisions  of  Section   2.2.4(b)  above.   The
         Conversion  Price shall be further  adjusted in the manner provided for
         herein, and only downwards, in the event that the conversion,  exercise
         or exchange price of Convertible  Securities is reset subsequent to the
         issuance thereof. For such purposes, all cash consideration received by
         Unigene upon  issuance  thereof and which  Unigene would be entitled to
         receive  upon  exercise,  conversion  or exchange  of such  Convertible
         Securities, shall be deemed to have been received upon issuance of such
         Convertible  Securities,  and the  maximum  number of  shares  (without
         giving  effect to the  anti-dilution  provisions  of such  instruments)
         issuable upon full exercise thereof shall be deemed  outstanding  after
         the issuance of such  Convertible  Securities for which  adjustment has
         been made hereunder for purposes of the Section  2.2.4(b)  calculation.
         No  adjustment  shall  be made  for the  issuance  of  shares  upon the
         exercise,  conversion  or exchange of any  Convertible  Security if any
         adjustment  was made with respect to the  issuance of such  Convertible
         Security.

                           (d) Subdivisions and Combinations.  In the event that
         Unigene  authorizes  a  stock  split  of or  otherwise  subdivides  the
         outstanding   shares  of  Common  Stock,  the  Conversion  Price  shall
         forthwith be proportionately decreased by multiplying it by a fraction,
         the numerator of which shall be one and the  denominator of which shall
         be the number of shares of Common Stock into which each share  existing
         before the subdivision was subdivided. Reverse stock splits and similar
         combinations of the outstanding  shares of Common Stock shall result in
         an adjustment reciprocal to that which is described above.

                           (e) Reclassifications,  Consolidations, Mergers, etc.
         In case of any  reclassification or change of the outstanding shares of
         Common  Stock  (other than a change from par value to no par value,  or
         from no par  value to par  value,  or as a result of a  subdivision  or
         combination),  or in the case of any  consolidation of Unigene with, or
         merger of Unigene into, another corporation (other than a consolidation
         or merger in which Unigene is the surviving  corporation and which does
         not result in any  reclassification or change of the outstanding shares

         of  Common  Stock,  except a change  as a result  of a  subdivision  or
         combination of such shares or a change in par value, as aforesaid),  or
         in the  case of a sale or  conveyance  to  another  corporation  of the
         property of Unigene as an entirety or substantially as an entirety, the
         Purchasers  shall have the right to convert the  Debentures,  as of the
         date of such reclassification,  change, consolidation,  merger, sale or
         conveyance  so as to  acquire  the kind and  number of shares of Common
         Stock  and  other   securities  and  property   receivable   upon  such
         reclassification, change, consolidation, merger, sale or conveyance due
         to the  Purchasers  or  the  owners  of  the  shares  of  Common  Stock
         underlying  the Debentures  acquired at the conversion  price in effect
         immediately prior to the record date for such reclassification, change,
         consolidation,  merger, sale or conveyance;  provided that in the event
         of a sale or  conveyance  to another  corporation  of the  property  of
         Unigene as an entirety or  substantially  as an entirety or in the case
         of a consolidation  of Unigene with or a merger of Unigene into another
         corporation  (hereinafter  a "Sale  Transaction"),  Purchasers  may, at
         their option,  require that the Debentures be paid off,  within 45 days
         of  the  closing  of  the  Sale  Transaction,  as  follows:  (i) if the
         consideration to be paid to the holders of Common Stock under the terms
         of the Sale  Transaction  is either  cash or readily  marketable  stock
         (i.e.,  stock that is traded on the NASDAQ or on a national  securities
         exchange issued by an issuer with a market  capitalization in excess of
         $100 million and with an average daily trading  volume in excess of the
         number of shares issued in the Sale  Transaction),  then the Purchasers
         shall receive such cash or readily  marketable  stock on the same basis
         as all other holders of the Common Stock;  however, (ii) if, and to the
         extent  that,  the  consideration  to be paid to the holders of Unigene
         Common Stock under the terms of the Sale  Transaction is anything other
         than as stated in (i), the  Purchasers  may require that the Debentures
         not be  converted  but  rather  be paid off in cash at $1.25  for every
         $1.00 then owing on the  Debentures  (in respect of both  principal and
         accrued  interest),  such  payment  to be  made  within  10 days of the
         consummation of such Sale Transaction.

                           (f) Dividends and Other Distributions with Respect to
         Outstanding Securities.  In the event that Unigene shall, except as set
         forth in Section 2.2.4(g) and with  Purchasers'  consent as required by
         Section  6.5,  at  any  time  prior  to  the  conversion  of all of the
         Debentures declare a dividend (other than a dividend  consisting solely
         of shares  of Common  Stock or  rights  to  purchase  Common  Stock) or
         otherwise  distribute without market value  consideration  paid, to its
         shareholders  any  monies,  assets,  property,   rights,  evidences  of
         indebtedness,  securities  (other than shares of Common Stock or rights
         to  purchase  Common  Stock),  whether  issued by Unigene or by another
         Person, or any other thing of value, the Purchasers shall thereafter be
         entitled, in addition to the shares of Common Stock or other securities
         receivable upon the conversion  thereof,  to receive,  upon conversion,
         the same monies,  property,  assets, rights, evidences of indebtedness,
         securities  or any  other  thing of value  that  they  would  have been
         entitled to receive at the time of such  dividend or  distribution.  At
         the time of any such  dividend  or  distribution,  Unigene  shall  make
         appropriate reserves to ensure the timely performance of the provisions
         of this Section 2.2.4(f).

                           (g) Subscription Rights for Shares of Common Stock or
         Other Securities.  In the case Unigene or an Affiliate of Unigene shall
         at any time, without market value consideration paid, distribute to its
         shareholders  any rights to subscribe for shares of Common Stock or any
         other securities of Unigene or of such Affiliate,  the Purchasers shall
         be  entitled,  in  addition  to the  shares  of  Common  Stock or other
         securities  receivable upon  conversion,  to receive such rights at the
         time such rights are distributed to the other  shareholders of Unigene,
         on the same basis as the Purchasers would have received such rights had
         the Debentures been converted  immediately prior to the record date for
         such distribution.

                           (h)  Consideration;  Expenses,  etc. For the purposes
         hereof, the consideration  received by Unigene in any transaction shall
         be deemed to be the gross amount  received  therefor  before  deducting
         underwriters'  discounts,  legal fees, finders fees and other costs and
         expenses  incurred in connection  with such issuance or sale determined
         as of the date not  later  than 45 days  after the date of the close of
         the offering with respect to such issuance or sale.

                           (i)   Exceptions  to   Adjustments.   Notwithstanding
         anything  to the  contrary  herein set forth,  no  adjustment  shall be
         required to be made:

                           (i)  upon the issue or exercise of any conversion or
                           exercise option associated with the Debentures or the
                           Purchased Warrants; or

                           (ii) upon the  exercise of any option  heretofore  or
                           hereafter granted to employees,  outside directors or
                           consultants  to Unigene  pursuant to any benefit plan
                           of Unigene; or

                           (iii) upon the  issuance  or sale of Common  Stock or
                           other securities upon the exercise or exchange of any
                           Convertible  Securities  to subscribe for or purchase
                           Common  Stock  which  were  outstanding  on the  date
                           hereof.

                               2.2.5  Preemptive  Rights.  The Purchasers  shall
have preemptive  rights to acquire,  on the same terms as any other purchaser in
any  public or private  financing  transaction  by  Unigene  of Common  Stock or
securities (other than upon the exercise,  conversion or exchange of outstanding
securities) exercisable to purchase or convertible into Unigene Common Stock (or
any  security  with the economic  terms of the Common Stock or such  securities,
whether a "synthetic  equity," a "swap" or whatever),  up to such amount of such
Common Stock or  securities as would result in the  Purchasers  holding the same
percentage of the  outstanding  Common Stock,  on a fully diluted basis, as such
Purchasers held prior to such issuance,  disregarding  securities whose exercise
or conversion  price is $3.75 or more in excess of the average closing bid price
for the Common  Stock for the thirty  trading  days  prior to such  issuance  of
additional  securities by Unigene. Such preemptive rights shall not apply to (i)
the  contemplated  offering  by Unigene of its  convertible  debentures  through
Swartz Investments, LLC and (ii) other offerings of securities prior to December
31, 1996 which offerings are  individually  for 50,000 shares of Common Stock or
less, and which in the aggregate total 250,000 shares of Common Stock or less.

                               2.2.6 Registration Rights. Unigene shall file and
use  commercially  reasonable  efforts  to keep a shelf  registration  statement
effective  covering  resales of the Common Stock issuable upon conversion of the
Debentures  for a period (the  "Registration  Period")  commencing no later than
June 30, 1996 and ending no later than the earlier of (i) February 28, 1999, and
(ii) the date upon  which the  Purchasers  are able to resell  all of the Common
Stock into which the Debentures are convertible without registration.

                               2.2.7 Redemption.

                           (a) The  Debentures  are subject to redemption at the
         election of Unigene as of the 15th day of each month beginning December
         15,  1996,  upon not less than thirty (30) days'  notice,  in a maximum
         principal amount of up to $495,000 per month, provided that the average
         closing  bid price of the  Common  Stock on the  NASDAQ  or a  national
         securities  exchange exceeds 200% (the "Redemption Target  Percentage")
         of the  Conversion  Price for 20 of the 30 trading days  preceding  the
         date of notice.  Such required  Redemption  Target  Percentage shall be
         adjusted   downward  each  month  by  2.083%  such  that  the  required
         Redemption Target Percentage will be 175% of the Conversion Price after
         December 15, 1997,  as  contemplated  by the following  paragraph.  The
         redemption  price  shall  be  equal  to  100% of the  principal  amount
         redeemed,  plus any accrued but unpaid interest to the redemption date.
         Notwithstanding  the foregoing  sentence,  interest  installments whose
         stated  maturity  is on or prior to any such  redemption  date  will be
         payable to the holders of such Debentures as of such redemption date.

                           (b) The  Debentures  are subject to redemption at the
         election of Unigene as of the 15th day of each month beginning December
         15,  1997 upon not less than  thirty  (30) days'  notice,  in a maximum
         principal amount of up to $1,100,000, provided that the average closing
         bid price for the Common  Stock on the NASDAQ or a national  securities
         exchange  exceeds 175% of the Conversion Price for 20 of the 30 trading
         days preceding the date of notice.  The redemption price shall be equal
         to 100% of the  principal  amount  redeemed plus any accrued but unpaid
         interest  to  the  redemption  date.   Notwithstanding   the  foregoing
         sentence, interest installments whose stated maturity is on or prior to
         such  redemption date will be payable to the holders of such Debentures
         as of such redemption date.

                           (c) In the event that either (i) the Common  Stock is
         not listed on NASDAQ or any  national  securities  exchange or (ii) the
         Common Stock  issuable  upon  conversion  of the  Debentures is not the
         subject of an effective registration statement permitting the immediate
         resale of such Common Stock,  Unigene  cannot  exercise its  redemption
         option.  In the event  that  Unigene is  eligible  to and does elect to
         redeem any portion of the Debentures,  the Debenture holders shall have
         the right to convert all or part of the  Debentures  to Common Stock at
         any time  through the close of business on the  redemption  date of the
         Debentures.  Upon  any  conversion  of the  Debentures,  the  Debenture
         holders  shall be  entitled  to receive  any  interest  accrued on such
         Debentures through the close of business on the conversion date.

                           (d) In the event of redemption  of the  Debentures in
         part only, a new Debenture or  Debentures  for the  unredeemed  portion
         will  be  issued  in the  name  of the  holder  of the  Debenture  upon
         cancellation of the redeemed Debenture.

                               2.2.8   Security.   The  amounts  due  under  the
Debentures,  including  all  accrued  but unpaid  interest,  shall be secured by
certain Collateral as provided in the Security Agreement.

                               2.2.9 Transfer.

                           (a) Unigene  shall cause to be kept at its  corporate
         offices a register (the  register  maintained in such office and in any
         other office or agency of Unigene being herein sometimes referred to as
         the  "Security   Register")  in  which,   subject  to  such  reasonable
         regulations  as  it  may  prescribe,  Unigene  shall  provide  for  the
         registration of the Debentures and of the  registration of transfers of
         the Debentures. Unigene shall act as Security Registrar for the purpose
         of  registering  Debentures  and  transfers  of  Debentures  as  herein
         provided.

                           (b) Upon  surrender for  registration  of transfer of
         any Debenture at the office of Unigene,  Unigene shall execute and make
         available for  delivery,  in the name of the  designated  transferee or
         transferees,  one or more new  Debentures  of the same  series,  of any
         authorized  denominations and of a like aggregate  principal amount and
         maturity  or  expiration   date.   All   Debentures   issued  upon  any
         registration  of transfer or exchange of Debentures  shall be the valid
         obligations of Unigene, evidencing the same obligation, and entitled to
         the same benefits under this Agreement,  as the Debentures  surrendered
         upon such registration of transfer or exchange.

                           (c) Every  Debenture  presented  or  surrendered  for
         registration  of  transfer  or for  exchange  shall (if so  required by
         Unigene) be duly endorsed or be accompanied by a written  instrument of
         transfer  in  a  form  satisfactory  to  the  Security  Registrar  duly
         executed,  by the holder  thereof or his attorney  duly  authorized  in
         writing.

                           (d) Unless otherwise provided in the Debentures to be
         transferred  or  exchanged,  no  service  charge  shall be made for any
         registration of transfer or exchange of Debentures.

                           (e) Unigene  shall not be  required  to register  the
         transfer of or exchange any Debenture  selected for redemption in whole
         or in part,  except  the  unredeemed  portion  of any  Debenture  being
         redeemed in part.

               2.2.10 Legend. Each Debenture and each certificate
for shares of Common Stock issued upon the  conversion of the  Debentures  shall
bear a restrictive legend as contemplated by Section 4.3 of this Agreement.

                               2.2.11  Authentication.  The Debentures  shall be
executed on behalf of Unigene by its Chairman of the Board, its President or one
of its Vice Presidents,  under its corporate seal reproduced thereon attested by
its Secretary or one of its Assistant Secretaries.

The  Debentures  together  with any other  document  executed  pursuant  to this
Agreement are hereinafter referred to collectively as the "Documents."

                               2.2.12 Limit on Purchasers'  Equity Ownership and
Number of Shares Issuable upon Conversion of the Debentures.  Purchasers may not
acquire,  pursuant to  anti-dilution  adjustments  or otherwise,  in excess of a
19.5% "fully-diluted"  equity interest in Unigene's Common Stock,  calculated on
the basis prescribed by Securities  Exchange Act Rel. No. 8325, i.e.,  including
all shares of Common Stock into which the Debentures and the Purchased  Warrants
are convertible or exercisable  (regardless of conversion or exercise price), as
the case may be, as outstanding but excluding all shares of Common Stock subject
to acquisition upon conversion or exercise of any derivative  securities held by
any other  investors  (again,  regardless  of  conversion  or  exercise  price).
Consequently,   at  each  time  that  the  number  of  shares  of  Common  Stock
beneficially  owned by the Purchasers  (i.e.,  into which the Debentures and the
Purchased  Warrants are  convertible or  exercisable) is adjusted upward through
the reset of the Conversion Price or the Purchased  Warrants'  exercise price or
otherwise,   a  sufficient   principal   amount  of  the  Debentures   shall  be
automatically  converted into such principal  amount of  Non-Convertible  Senior
Secured  Debentures,  in each case due on November 15, 1998 (and  otherwise upon
events of default as specified in the  Debentures)  and bearing  interest at 17%
per annum, so that Purchasers'  "fully-diluted"  equity interest,  calculated as
set forth above,  does not exceed  19.5%.  The  Non-Convertible  Senior  Secured
Debentures shall be secured pari passu with the Debentures.

                               In  addition  to  the  foregoing   limitation  on
Purchasers' aggregate equity interest in Unigene, and,  notwithstanding any term
or provision of this  Agreement or the  Debentures to the contrary,  in no event
may the total  number of shares  issuable  upon  conversion  of the  Debentures,
irrespective  of which  party or  parties  holds the  Debentures  at the time of
conversion,  exceed 19.5% of Unigene's  outstanding  Common Stock as of the date
hereof.

                  3.  Representations and Warranties of Unigene.  Unigene hereby
represents and warrants to the Purchasers that:

                           3.1   Standing  and   Qualification.   Unigene  is  a
corporation duly organized, validly existing and in good standing under the laws
of the State of Delaware. Unigene is not, nor is it required to be, qualified or
licensed to transact  business  as a foreign  corporation  under the laws of any
State  other  than the  State of its  incorporation  and New  Jersey in order to
enable it to conduct its business as it is  presently  being  conducted,  except
where the failure to be so qualified or licensed is not  reasonably  expected to
have a material adverse effect on its financial condition,  assets,  business or
results  or  operation  or its  ability to perform  its  obligations  hereunder.
Unigene is duly qualified as a foreign corporation and is in good standing under
the laws of the  State of New  Jersey.  Unigene  has full  corporate  power  and
authority  to own or lease its  properties  and other  assets and to conduct its
business as it is now being conducted.

                           3.2  Subsidiaries.  Except as set  forth in  Schedule
3.2,  Unigene does not own any capital  stock or other voting  securities of any
corporation,  partnership or other  organization.  Unigene is not a party to any
joint venture or partnership.  Unigene is the sole vehicle through which Unigene
and its Affiliates conducts its and their business.

                           3.3  Capitalization.  The authorized capital stock of
Unigene consists of 48,000,000  shares of Common Stock, of which, as of December
31, 1995, 23,813,171 shares are issued and outstanding.  There are no dividends,
whether  current or  accumulated,  due or payable on any of the capital stock of
Unigene.

                           3.4  Interests  in  Unigene  Securities.   Except  as
disclosed in Unigene's  Form 10-Q for the  quarter-end  September  30, 1995 (the
"1995 Form 10-Q") or Schedule 3.4, there are no outstanding options, convertible
securities,  warrants or other rights to subscribe for or purchase from Unigene,
nor any plans,  contracts or  commitments  providing for the issuance by Unigene
of, or for the granting by Unigene of rights to acquire:  (i) any capital  stock
in Unigene;  or (ii) any securities  convertible  into or  exchangeable  for any
capital stock or other ownership interest in Unigene.

                           3.5  Authority.  Unigene  (i) has the full  corporate
right,  power and authority to execute and deliver this Agreement and to perform
its  obligations  hereunder and to execute,  deliver and perform its obligations
under the  Documents  (as  defined  in Section  2.2.11),  and (ii) has taken all
necessary  corporate  actions  to  approve  and adopt  this  Agreement  and such
Documents and to authorize the performance of this Agreement and such Documents.
Upon  execution and delivery,  this Agreement and each of the Documents to which
Unigene  is a party is the duly  authorized,  valid and  binding  obligation  of
Unigene,  enforceable  against it, in accordance with its terms,  except as such
enforceability may be limited by applicable bankruptcy,  insolvency, moratorium,
reorganization,  or similar  laws from time to time in effect  which  affect the
enforcement  of  creditors'   rights   generally  and  by  legal  and  equitable
limitations on the  availability  of specific  performance  and other  equitable
remedies  against  it,  public  policy,  and with  respect  to the  priority  of
Purchasers, security interest, subject to applicable filing requirements.

                           3.6  Absence of Conflicts and Consents.  Neither the
execution and delivery of this Agreement and the Documents nor the  consummation
of the  transactions  contemplated  hereby or thereby will (i) breach or violate
any of the terms and  conditions of the Articles of  Incorporation  or Bylaws of
Unigene, or (ii) breach or violate any judgment,  order,  injunction,  decree or
ruling of any court,  arbitrator  or any  governmental  authority,  domestic  or
foreign,  or  any  material  contract,  material  agreement  or  other  material
instrument  to which  Unigene  is a party or any of its  respective  properties,
rights or  assets  is  subject  or which it is bound or with any  statute,  law,
ordinance,   rule  or  regulation  of  any  federal,  state,  local  or  foreign
governmental  authority or regulatory body, the breach or violation of which (A)
would have a material adverse effect on Unigene's properties,  assets, business,
operations,  prospects or financial condition or (B) would impair the ability of
Unigene to execute,  deliver or perform its obligations  under this Agreement or
any Document,  (C) would terminate or result in the cancellation of any payments
under any such  agreement,  contract or  instrument  or (D) would  result in any
material  damages or result in or, except as  contemplated  by this Agreement or
the  Documents,  require the creation or  imposition of any  Encumbrance  of any
nature upon or with respect to any of its properties or assets.

                           3.7 Title to;  Condition  of Assets;  Real  Property.
Except as set forth in Schedule  3.7, all of  Unigene's  assets,  including  the
Premises (as defined in the Mortgage) and Collateral (as defined in the Security
Agreement),  are owned  free and clear of all  material  Encumbrances.  All such
personal  property is in good  operating  condition and in a state of reasonable
maintenance and repair, fit for the purpose for which it is intended. Unigene is
the lessee of property  located at 83 Fulton Street,  Boonton,  NJ pursuant to a
lease dated May 20,  1993,  as amended by First  Amendment to Lease on that same
day. Such lease is in full force and effect and has not been further modified or
amended,  and no event has  occurred  that,  with the passage of time or notice,
would constitute a default thereunder. All other leases that, individually or in
the  aggregate,  are material are valid and subsisting and are in full force and
effect in all material respects.

                           3.8  Conduct of Business.

                           (a) Since September 30, 1995,  except as set forth in
         Schedule  3.8  or  in  its  1995  Form  10-Q,   Unigene  has  preserved
         substantially intact its business organization.

                           (b)  Except  as set forth in  Schedule  3.8 or in its
         September  30, 1995 Form 10-Q,  Unigene has conducted its business only
         in the  ordinary  and usual  course of  business  consistent  with past
         practice and there has not been:

                           (i) any  increase in its  indebtedness  for  borrowed
                           money  incurred  by or on  behalf of  Unigene  or any
                           incurrence  of  any  other  material   obligation  or
                           liability  (fixed or  contingent)  by or on behalf of
                           Unigene,   except  for  the  additional  indebtedness
                           incurred  by  Unigene  through  borrowings  from  the
                           Purchasers,  and except for  obligations  incurred in
                           the ordinary course of business  consistent with past
                           practice;

                           (ii) except for increased  indebtedness  and decrease
                           in stockholders  equity,  any material adverse change
                           in its  assets,  liabilities,  properties,  business,
                           financial  condition or results of  operations or any
                           development  of which its  management  has  knowledge
                           which is  reasonably  likely  to  result  in any such
                           change  other  than any such  change  resulting  from
                           changes in general economic conditions;

                           (iii) any  damage,  destruction,  loss or claim to or
                           against any of its property or other assets,  whether
                           or  not  covered  by  insurance,   which   materially
                           adversely affects its assets,  properties,  business,
                           profits or financial condition;

                           (iv) any sale,  lease,  transfer or other disposition
                           or  mortgage  or pledge of any of its  properties  or
                           other assets,  or an imposition of any Encumbrance on
                           any of its  properties  or other  assets,  other than
                           transactions  in  the  ordinary  course  of  business
                           consistent with past practice;

                           (v) any  cancellation  of any debts owed to or claims
                           held by or on behalf  of  Unigene,  or any  waiver or
                           release of any of its rights of material value;

                           (vi) any dividend or other distribution or payment in
                           respect of, any  subdivision,  consolidation or other
                           recapitalization   of  its   capital   stock  or  any
                           declaration or authorization of any of the foregoing;

                           (vii) any issuance of  additional  warrants or rights
                           to  acquire  any  equity  security  or  any  security
                           convertible  into any  equity  security  of  Unigene,
                           except as contemplated by this Agreement; or

                           (viii) other than as  contemplated by the Commitment,
                           Unigene  has not  agreed  or  consented  to  cause or
                           permit  in  the  future  (upon  the  happening  of  a
                           contingency  or otherwise)  any of its  properties or
                           assets  whether now owned or hereafter  acquired,  or
                           any  income  or  profits  therefrom,  to be or become
                           subject to a lien.

                           3.9 Financial Statements;  SEC Filings. The Financial
Statements (i) were prepared in accordance with the books of account and records
of Unigene,  which  accurately  reflects all assets and transactions of Unigene,
and (ii) present fairly  Unigene's  financial  condition as of the dates thereof
and its results of  operations  for the periods  then ended in  accordance  with
GAAP,  subject,  in the case of the interim  Financial  Statements,  to routine,
recurring year-end  adjustments.  As of the date hereof,  except as set forth in
the  Financial  Statements,  Unigene  has no  material  contingent  liabilities,
liabilities for taxes, unusual commitments or unrealized or unanticipated losses
which are  required to be reflected on a balance  sheet  prepared in  accordance
with GAAP. Unigene has delivered to the Purchasers its Forms 10-K for the fiscal
years  ended  December  31, 1993 and 1994 and its Forms 10-Q for the first three
fiscal quarters of 1995 as filed with the Securities Exchange  Commission.  Such
reports do not contain any untrue statement or omission of any material fact.

                           3.10  Tax and  Other  Returns  and  Reports.  (i) All
federal,  foreign,  state,  provincial and local tax returns and tax reports (or
extensions  relating thereto) required to be filed by or on behalf of Unigene or
any  affiliated,  combined or unitary  group of which Unigene is or was a member
have been filed on a timely basis with the appropriate  governmental agencies in
all jurisdictions in which such returns and reports are required to be filed and
all such returns and reports were true and correct in all material respects when
filed;  and (ii) all  federal,  foreign,  state,  provincial  and local  income,
profits,  franchise,  sales,  use,  occupancy,   property,   severance,  excise,
withholding,  value  added and other taxes as shown on such  returns  (including
interest  and  penalties)  due  from  Unigene  either  directly,  as part of the
consolidated tax return of another taxpayer,  or otherwise,  have been fully and
timely paid, or where payment is not required to have been made, Unigene has set
up an adequate  reserve or accrual for such  payment.  Unigene knows of no basis
for any other tax,  assessment or governmental  charge that,  individually or in
the aggregate, could reasonably be expected to have a material adverse effect on
Unigene, its operations or prospects.

                           3.11  Intellectual Property.

                           (a) Schedule 3.11(a)  accurately lists all registered
         United  States and  Foreign  Patents  and  Trademarks,  and all pending
         United  States  Patent  and  Trademark  applications  that are owned or
         controlled by Unigene.

                           (b)   Schedule    3.11(b)    accurately   lists   all
         Intellectual  Property owned or controlled by others  besides  Unigene,
         the use of which is licensed  to  Unigene.  Unigene is not aware of any
         other  Intellectual  Property  owned or  controlled  by others  besides
         Unigene  that is  material  to the  ability of  Unigene to operate  its
         business as it is currently conducted or as currently contemplated.

                           (c)   Schedule    3.11(c)    accurately   lists   all
         Intellectual  Property  rights  licensed or granted by Unigene to third
         parties.

                           Unigene is the sole and exclusive owner of the entire
         right,  title  and  interest  in  and  to  the  Intellectual   Property
         identified on Schedule  3.11(a) and except for such licenses and rights
         identified on Schedule 3.11(c),  Unigene has not granted nor does there
         exist by implication or operation of law, any license or other right in
         respect  thereof  which  does or  which  will,  subsequent  to the date
         hereof,  permit or enable  any  Person  other  than  Unigene to use the
         Intellectual  Property and,  moreover,  except as set forth in Schedule
         3.11(c),   none  of  said  Intellectual  Property  is  subject  to  any
         Encumbrance. As of the date hereof, there is no pending or, to the best
         knowledge of Unigene,  threatened  claim against Unigene  asserting (A)
         that Unigene's use of any of said  Intellectual  Property  infringes or
         violates  any  rights of third  parties,  (B) that the past or  present
         conduct of Unigene's business infringes or violates the rights of third
         parties,  (C) that any third parties have any rights to use any of said
         Intellectual Property or (D) except as set forth in Schedule 3.15, that
         any third  parties  have or will have any right which  could  adversely
         affect Unigene's ability to use any of the Intellectual  Property after
         the date  hereof;  and to the best  knowledge  of Unigene,  there is no
         basis for any claim of the foregoing  types.  Neither the  Intellectual
         Property  nor  Unigene's  past  or  present  conduct  of  its  business
         infringes or violates the rights of third parties. During the past five
         (5)  years,  Unigene  has not  given any  notice  to any third  parties
         asserting   infringement   by  such  third   parties  of  any  of  said
         Intellectual  Property.  To the best knowledge of Unigene,  there is no
         material  violation  by any person of any right of Unigene with respect
         to the Intellectual Property. Unigene is not aware of any bars or other
         restrictions  with  respect  to its  rights  to  utilize  any  of  said
         Intellectual  Property,  and no bars or other restrictions on Unigene's
         rights to utilize any of said Intellectual Property will be created by,
         or will,  by reason of any action or inaction  by  Unigene,  before the
         date  hereof,   exist  after  the   consummation  of  the  transactions
         contemplated hereby.

                           Nothing has come to the  attention  of Unigene  which
         has led  Unigene  to form the  opinion  that  any of said  Intellectual
         Property  is  invalid  or that its  rights in any of said  Intellectual
         Property are  unenforceable  in any way,  with the proviso that pending
         patent  applications are merely requests for patents,  and there can be
         no guarantee  that those  requests will be granted and that any patents
         will  necessarily be issued based upon said pending  applications,  and
         with the further proviso that applications for trademark  registrations
         are merely  requests for  registration  which may or may not ultimately
         result in registration with the U.S. Patent and Trademark  office.  The
         execution  and  delivery  of this  Agreement  will not affect or impair
         Unigene's  right to continue to use all of said  Intellectual  Property
         without the impairment or alteration thereof and without the payment of
         any license or other fees (other  than that the  license  fees  payable
         under the License Agreements identified in Schedule 3.11(b)).

                           All of the License Agreements  identified on Schedule
         3.11(b) are valid  agreements,  enforceable  in  accordance  with their
         terms,  except that such  enforceability  may be limited by  applicable
         bankruptcy,  insolvency,  moratorium,  reorganization,  bulk  sales  or
         similar laws from  time-to-time  in effect which affect the enforcement
         of creditors'  rights generally and by legal and equitable  limitations
         on  the  availability  of  specific  performance  and  other  equitable
         remedies.  There is no pending  or, to the best  knowledge  of Unigene,
         threatened  claim against  either  Unigene or, to the best knowledge of
         Unigene, the licensor of any Licensed  Intellectual  Property asserting
         that any of the Licensed  Intellectual  Property infringes or conflicts
         with the rights of third  parties,  or that the present or past conduct
         of  Unigene's  business  infringes  or  violates  the  rights  of third
         parties,  and to the best  knowledge of Unigene,  no basis for any such
         claim exists.

                           3.12  ERISA.  Unigene has  complied  in all  material
respects with the  requirements  of ERISA;  no  Reportable  Event (as defined in
ERISA) has  occurred and is  continuing  with respect to any Plan (as defined in
ERISA); and it has no unfunded vested liability under any Plan.

                           3.13  Permits and Licenses.

                           (a)  List  of  Governmental  Permits.  Set  forth  on
         Schedule  3.13(a) is a list and  description  of all Permits  which are
         issued to, held or used by Unigene,  or for which  Unigene has applied,
         and  which  are  material  to  the  operation  and  development  of its
         business.  There  are  no  other  Permits  which  are  material  to the
         operation of Unigene's  business as now conducted.  Except as otherwise
         indicated, all Permits listed in Schedule 3.13(a) are in good standing,
         valid and effective in accordance with their respective terms.  Unigene
         owns the Permits,  free and clear of all Encumbrances and subject to no
         Claims.

                           (b) Compliance  with Permits.  Except as set forth on
         Schedule  3.13(b),  Unigene is in material  compliance with all Permits
         listed  on  Schedule   3.13(a)  and  no  governmental   proceedings  or
         investigations  are  pending  or,  to the best  knowledge  of  Unigene,
         threatened against it relating to noncompliance with such Permits.

                           3.14   Governmental   Authorizations.   No   consent,
approval or authorization  of, or registration,  filing or declaration with, any
governmental authority is required in connection with the execution, delivery or
performance  by Unigene of this  Agreement  or any of the  Documents  other than
those required with respect to the  registration  contemplated  in Section 2.2.6
and  the  security  interest  filings  contemplated  in this  Agreement  and the
Documents.

                           3.15 Litigation and Proceedings.  Except as set forth
on  Schedule  3.15,  there  are no causes  of  action  or other  litigations  or
arbitrations  or  regulatory,   administrative,  zoning  or  other  governmental
proceedings  or  investigations  presently  pending or, to the best knowledge of
Unigene, threatened, before any court, arbitrator,  governmental agency or other
forum either against  Unigene or any of its properties or assets which relate in
any way to Unigene or any of its properties or assets.

                           3.16 FDA Status. The Unigene manufacturing process is
undergoing  formal  validation  in  order  to  obtain  GMP  (Good  Manufacturing
Practice) status.  Unigene has completed testing of the manufacturing  equipment
and  is  now  performing  the  various  manufacturing  process  operations.  The
validation process is essentially  complete when three consecutive  "conformance
batches"  (batches  in  which  all of the  in-process  and  final  product  test
specifications have been met and which are performed in compliance with all cGMP
requirements) of product have been prepared. Unigene has received no notice, and
is not aware of any  state of facts  that  would  lead it to  believe,  that its
Boonton, New Jersey facility will not receive FDA validation to allow Unigene to
produce its Calcitonin for human use in the United States. Finally,  Unigene has
been advised verbally by the FDA that only brief clinical  programs  designed to
test safety and bioequivalence  should be required for the approval of Unigene's
injectable Calcitonin product. Following validation,  Unigene intends to file an
IND  (investigational  new drug  application) and initiate  clinical programs to
support such product approval in 1996.

                           3.17  Environmental  Laws.  Unigene  has  received no
notice, and is not aware of any state of fact that would lead it to believe that
there exists,  or has existed at any real property occupied by it, any hazardous
material in violation of any environmental law, rule or regulation.

                           3.18 Judgments,  Orders and Consent Decrees.  Unigene
is not  subject to any  judgment,  order or decree of, or  agreement  with,  any
court,  arbitrator or regulatory  authority  limiting,  restricting or adversely
affecting  its conduct,  financial  condition or operating  result,  and no such
judgment, order, decree or agreement is pending.

                           3.19  No  Omissions.  No  representation,   warranty,
covenant or  agreement  of Unigene in this  Agreement,  any  schedule or exhibit
attached hereto, or any Document contains nor shall contain any untrue statement
of material fact nor omits nor shall omit to state any material  fact  necessary
to make the statements contained herein and therein not misleading.

                  4.  Representations and Warranties of the Purchasers.

                           4.1  Standing and Capacity.

                           (a) Olympus  represents  and warrants to Unigene that
         it has all requisite  legal and corporate  power to execute and deliver
         this  Agreement  and the  other  Documents  to which it is a party,  to
         purchase  the  Debentures,  and to perform its  obligations  under this
         Agreement and the other  Documents to which it is a party.  Olympus has
         the  capacity  to  enter  into  the  transactions  contemplated  by the
         Documents;  neither the  execution,  delivery nor  performance  of this
         Agreement or the Documents violates any law, rule or regulation, of any
         jurisdiction,  court or administrative judgment, order or decree or any
         agreement applicable to or binding upon Olympus.

                           (b) Nelson represents and warrants to Unigene that it
         has all requisite  legal and  partnership  power to execute and deliver
         this  Agreement  and the  other  Documents  to which it is a party,  to
         purchase  the  Debentures,  and to perform its  obligations  under this
         Agreement  and the other  Documents to which it is a party.  Nelson has
         the  capacity  to  enter  into  the  transactions  contemplated  by the
         Documents;  neither the  execution,  delivery nor  performance  of this
         Agreement or the Documents violates any law, rule or regulation, of any
         jurisdiction,  court or administrative judgment, order or decree or any
         agreement applicable to or binding upon Nelson.

                           4.2 Authority. Each Purchaser represents and warrants
to Unigene that all action  necessary for the purchase of the Debentures and the
performance of its  obligations  under this Agreement and the other Documents to
which it is a party has been duly taken. The Agreement is valid and binding upon
it and  enforceable in accordance  with its terms except as such  enforceability
may be limited by applicable bankruptcy, insolvency, moratorium, reorganization,
bulk  sales,  or  similar  laws  from time to time in effect  which  affect  the
enforcement  of  creditors'   rights   generally  and  by  legal  and  equitable
limitations on the  availability  of specific  performance  and other  equitable
remedies against it, public policy.

                           4.3   Investment   Representation.   Each   Purchaser
represents  and warrants to Unigene that (i) it is acquiring the  Debentures for
investment,  for its own account as  principal  and not with the current view to
distribution or trade thereof, (ii) it is an "accredited investor" as defined in
Rule 501(a) and (iii) the questionnaire  executed and delivered by it to Unigene
in connection with the transactions  contemplated hereby is true and accurate in
all material respects and does not omit any material  information required to be
stated therein or necessary to make the Statements  made therein not misleading.
The  Debentures and shares issued upon  conversion of the Debentures  shall bear
restrictive  legends that are customary for  securities  that are issued without
registration  under the  Securities  Act in  reliance  on a  "private  placement
exemption."

                  5. Affirmative  Covenants of Unigene.  Unigene covenants that,
until the principal of, and interest on, the  Debentures  and all other monetary
obligations  to the Purchasers  under the Debentures  have been paid in full, it
will:

                           5.1  Corporate Existence.  Do all things necessary to
preserve and keep in full force and effect its  existence  (corporate  or other)
and existing name, rights and franchises, and qualify and remain qualified to do
business in each  jurisdiction  in which the failure so to qualify  would have a
material adverse effect on its business,  operating results, assets or condition
(financial or otherwise) or prospects.

                           5.2 Insurance.  Schedule 5.2 lists insurance coverage
currently  maintained by Unigene.  No change in such insurance  coverage will be
made without the Purchasers' consent, which will not be unreasonably withheld or
delayed.

                           5.3  Keeping of Records  and Books of  Account.  Keep
adequate  records and books of account,  in which complete  entries will be made
reflecting all of Unigene's financial transactions.

                           5.4 Inspection  Rights.  At any reasonable  time, and
from time to time,  permit  representatives  of the Purchasers,  upon reasonable
notice to Unigene,  to examine and make copies of and abstracts from its records
and books of account of, and visit its properties  during normal  business hours
and to discuss its affairs,  finances and accounts  with any of its officers and
its independent  certified public  accountants.  The Purchasers agree to keep in
confidence and not to utilize or disclose any confidential  information provided
to them,  including,  without limitation,  financial  statements or information,
business plans, proposed financing or acquisition plans,  information concerning
Unigene's  products,   patents,  patent  applications,   trade  secrets,  secret
processes or other  proprietary  information  unless and until such confidential
information is publicly disseminated by Unigene. This confidentiality  provision
shall  survive the  execution  and  delivery of this  Agreement,  but if Unigene
defaults  on  its   obligations  and  the  Purchasers  take  possession  of  the

Collateral,  such  confidentiality  obligation  shall  terminate  to the  extent
reasonably necessary to enable the Purchasers to sell any of the Collateral.  In
such event, the Purchasers may disclose or use any confidential information in a
manner as it deems  necessary  (in its sole  judgment) to obtain  payment of all
Obligations.

                           5.5 Compliance with Laws.  Comply with the applicable
requirements  of  all  laws  and  all  rules,  regulations  and  orders  of  any
governmental  authority,  the violation of which might be reasonably expected to
have a material  adverse effect on its business,  operating  results,  assets or
condition (financial or other).

                           5.6 Reporting Requirements. Furnish to the Purchasers

                           (a) (i) Commencing with the month of March,  1996, as
                           soon as  practicable  and in any event within 40 days
                           after the close of each  monthly  accounting  period,
                           unaudited  financial  statements,   consisting  of  a
                           balance  sheet as at the end of such  monthly  period
                           and  statements  of  operations,  and  cash  flows of
                           Unigene  for such  monthly  period and for the period
                           from the  beginning  of the fiscal year to the end of
                           such monthly period;

                           (ii)  Commencing  with the  quarterly  period  ending
                           March 31, 1996,  as soon as possible and in any event
                           within  50 days  after the close of each of the first
                           three  quarterly  accounting  periods of each  fiscal
                           year, unaudited financial statements, consisting of a
                           balance sheet as at the end of such quarterly  period
                           and   statements   of    operations,    cash   flows,
                           shareholders'  equity for such  quarterly  period and
                           for the period from the  beginning of the fiscal year
                           to the end of such quarterly period; and

                           (iii) Annually, as soon as available but in any event
                           within 95 days after the close of each fiscal year of
                           Unigene,  a balance sheet of Unigene as at the end of
                           such  year and  statements  of  income  and  retained
                           earnings and of cash flow of Unigene  reflecting  the
                           results of its  operations  during  such year,  which
                           financial  statements  shall  be  used  by  Unigene's
                           independent  public accountants in the preparation of
                           Unigene's audited financial  statements for such year
                           end,  certified by the President and Treasurer of the
                           Unigene to fairly present its financial  condition at
                           such year end and the results of its  operations  for
                           such period in accordance with GAAP.

                           The  financial  statements  required to be  delivered
                           under this  Subsection  (a) shall contain  reasonable
                           detail and shall be certified by the Chief  Executive
                           Officer of Unigene and, in the case of the  financial
                           statements required to be delivered under clause (ii)
                           above, as (x) having been prepared in accordance with
                           GAAP,  subject to normal  year-end audit  adjustments
                           (except  that  footnotes  shall  not be  required  on
                           monthly  and  quarterly  financial  statements),  (y)
                           being complete and correct, and (z) presenting fairly
                           the  financial  condition,   results  of  operations,
                           shareholders'   equity  and  cash  flows  which  they
                           purport to present.

                           (b) Together with the quarterly financial  statements
         furnished  pursuant to Section 5.6(a),  there shall be delivered to the
         Purchasers  a  certificate  signed by the Chief  Executive  Officer  of
         Unigene  stating  that they  have  caused a review  of the  affairs  of
         Unigene to be made and that  based  thereon  nothing  has come to their
         attention  which  would lead them to believe  that any event of default
         ("Event  of  Default")  under the terms of the  Debenture  or any event
         which,  with the lapse of time or the  giving  of notice or both  could
         become an Event of Default has occurred or exists hereunder or, if such
         is not the case, specifying the nature thereof and what action has been
         taken  or is being  taken  or is  proposed  to be  taken  with  respect
         thereto.

                           (c) Promptly  after Unigene  discovers the occurrence
         of any Event of Default or any event  which,  with the lapse of time or
         the  giving of  notice or both,  could  become an Event of  Default,  a
         statement of Unigene's  President or Chief  Financial  Officer  setting
         forth  details of such  Event of Default or other  event and the action
         taken, or proposed to be taken, with respect thereto.

                           (d) Promptly  after  Unigene has  knowledge  thereof,
         notice of any action,  suit or proceeding  known to it before any court
         or governmental authority,  domestic or foreign, which might reasonably
         be  expected  to  have a  material  adverse  effect  on  its  business,
         earnings, assets or condition (financial or other).

                           (e)  Promptly  after the  sending or filing  thereof,
         copies of all proxy statements,  financial statements and reports which
         Unigene sends to its shareholders,  and copies of all reports,  and all
         registration  statements it files with the U.S. Securities and Exchange
         Commission  (the  "SEC")  or the  National  Association  of  Securities
         Dealers, Inc.

                           (f) Such other  information  respecting the business,
         operating results,  assets or condition (financial or other) of Unigene
         as the Purchasers may reasonably request from time to time.

                           (g)  Promptly,  but in any event not later than three
         business days after the receipt of a reasonable written demand from the
         Purchasers,  a certificate of its Chief Executive  Officer or the Chief
         Financial Officer, in form satisfactory to the Purchasers,  stating and
         acknowledging  (a)  the  then  outstanding  principal  balance  of  the
         Debentures,  (b),  the fact that  there  are no  defenses,  offsets  or
         counterclaims   thereto  (or   stating   such   defenses,   offsets  or
         counterclaims,  if any);  (c) that no  Event  of  Default  and no event
         which,  with the  giving of notice or the lapse of time or both,  would
         constitute such an Event of Default exists, or if such is not the fact,
         the facts and circumstances  relating to such Event of Default or other
         event; and (d) that no litigation or administrative proceeding has been
         instituted by or against Unigene if determined adverse to Unigene would
         have a material  adverse  effect on its  business,  operating  results,
         assets or condition  (financial  or other) or, if such is not the fact,
         the facts and circumstances relating to such litigation or proceeding.

                           5.7  Further  Assurances.   Unigene  shall,   without
further consideration,  take all such other action and shall procure or execute,
acknowledge, and deliver all such further certificates,  conveyance instruments,
consents,  and other  documents the  Purchasers or their counsel may  reasonably
request  to perfect  and  protect  Purchasers'  rights as  contemplated  by this
Agreement,  including, without limitation, their security interest in and to the
Collateral.

                  6.  Negative  Covenants.  Unigene  covenants  that  until  all
amounts  due under  the  Debentures  have  been  fully  paid,  unless  otherwise
expressly consented to in writing by the Purchasers, it will not:

                           6.1   Investments.   Make  or  permit  to  exist  any
investment in securities or other  financial  instruments  (including  loans and
advances), except:

                           (a)  Accounts  receivables  arising  in the  ordinary
         course of business;

                           (b) Notes or other  securities in connection with any
         bona fide  settlement  of  account  receivables  owing in the  ordinary
         course of business;

                           (c)  Direct  obligations  of  the  United  States  of
         America or any agency thereof, solely for investment purposes, provided
         the same shall mature within twelve months;

                           (d) Certificates of deposit, time deposits,  bankers'
         acceptances,  commercial  paper and similar short term bank deposits or
         instruments  having a  maturity  of not more  than  twelve  months of a
         commercial bank; and

                           (e)  Money market funds with a AAA rating.

                           6.2 Impair Value.  Take any action which would result
in a material  impairment  of the  overall  value of any  property  on which the
Purchasers shall have a lien.

                           6.3 Change of  Business.  Conduct any  business,  the
nature  of which  would  differ in any  material  respect  from  that  presently
conducted  by it or  contemplated  as set forth in its 1994  Annual  Report  and
September 30, 1995 Form 10-Q or which does not complement such business.

                           6.4 No New Entities.  Except as set forth in Schedule
3.2, form or acquire any corporation,  partnership,  joint venture or other kind
of entity for the  purpose of  transferring  to such person or entity any of its
assets or business of the type  presently  conducted by it, unless the assets so
transferred  remain subject to the  Purchasers'  lien and Unigene's  interest in
such entity is pledged to the Purchasers.

                           6.5  Merger;  Sale of Assets;  Reclassification.  (a)
Enter into any merger or consolidation in which it is not the surviving  entity,
(b)  liquidate,  wind up its affairs or  dissolve,  (c) sell,  lease,  transfer,
convey or otherwise dispose of all or substantially all of its assets or capital
stock or (d) reclassify or change the outstanding  shares of Common Stock (other
than a change  from par  value to no par value or from no par value to par value
or as a result of a subdivision or combination).

                           6.6 Dividends; Distributions. Directly or indirectly,
declare  or pay  dividends  or  otherwise  make any  distribution  or  assets or
anything of value in respect of its Common Stock or capital shares, or redeem or
repurchase any shares of the Common Stock or capital shares.

                           6.7  Increase  in  Compensation.  Until  such time as
Unigene's  Boonton facility  achieves cGMP status and Unigene has entered into a
definitive   agreement  with  one  or  more  Strategic  Partners,   directly  or
indirectly,  increase  compensation paid to any person who is or was an officer,
director  or  Affiliate  of  Unigene.  At such  point as the  conditions  in the
foregoing  sentence  have been met,  then  Unigene's  directors may increase the
compensation  of each officer,  director or Affiliate by 10%, and thereafter may
provide  additional  reasonable and customary  increases in compensation to such
persons, as the directors may, in their discretion, determine.

                           6.8  No  Amendment.   Make  any  material  amendment,
modification  or change to any agreement or instrument  respecting  indebtedness
for money borrowed, or waive any of its rights or privileges thereunder, without
the Purchasers' prior written consent which will not be unreasonably withheld or
delayed.

                           6.9  Transactions with Affiliates and/or Associates.

                           (a) Enter into any transactions  with an Affiliate or
         Associate  of Unigene,  except as  contemplated  in this  Agreement  or
         except  in  the  ordinary   course  and  pursuant  to  the   reasonable
         requirements  of its  business,  and in good faith and upon  commercial
         reasonable  terms  or  conditions  that are no less  favorable  to such
         person or entity than would be  obtainable  at the time in a comparable
         arm's  length  transaction  with a  person  or  entity  other  than  an
         Affiliate and/or an Associate.

                           (b)  Except  as  expressly  permitted  by  any  other
         provision  of this Section 6, make any loan of money or property to any
         Affiliate,   or  become   contingently  liable  (through  guarantee  or
         otherwise)  to  any  person  with  respect  to any  indebtedness  of an
         Affiliate and/or Associate.

                           6.10   Disposition  of  Collateral.   Sell,   assign,
exchange or otherwise dispose of any Collateral except in the ordinary course of
business.

                           6.11 Loans. Make any loans or advances to any Person,
including without limitation Unigene's directors, officers and employees, except
(i) advances to officers or employees with respect to expenses  incurred by them
in the  ordinary  course of their  duties  which are  properly  reimbursable  by
Unigene;  and (ii) loans to employees  not  exceeding  $20,000 in the  aggregate
during  any  fiscal  year of  Unigene;  and  (iii)  advances  to  collaborators,
suppliers,  material men and with respect to research and  development  projects
made in the ordinary course of Unigene's business, but not to exceed $100,000 to
any one Person.

                           6.12  Negative Pledge.  Create or suffer to exist any
mortgage, pledge, liens, permits,  interest,  assignment or transfer upon any of
the  Collateral  which  purports  to be senior to or pari  passu with any of the
security for the Debentures, other than Permitted Liens.

                           6.13  Guarantees.   Assume,   guaranty,   endorse  or
otherwise  become  directly  or  contingently  liable in respect  to  (including
without  limitation by way of agreement,  contingent or otherwise,  to purchase,
provide  funds to or  otherwise  invest  in a debtor  or  otherwise  to assure a
creditor against loss), any Indebtedness of any other Person (except  guarantees
by endorsement of instruments  for deposit or collection in the ordinary  course
of business.

                           6.14 Removal of Hazardous Substances.  Should Unigene
cause or permit any intentional or  unintentional  act or omission  resulting in
the discharging of hazardous substances or wastes into the atmosphere or waters,
or onto lands,  resulting  in damage to the  natural  resources  without  having
obtained a permit issued by the appropriate  governmental  authorities,  Unigene
shall promptly clean up same in accordance  with all applicable  federal,  state
and local orders, statutes, laws, ordinances, rules and regulations.

                           6.15  Intent  and  Purpose.  It is the  intent of the
parties  that,  subject to this  Article  6,  until an Event of Default  and the
principal sum under the Debentures has become due and payable by acceleration or
otherwise,  Unigene may conduct its business in the ordinary course, may use its
cash, cash equivalents,  royalties, licensing fees, milestone payments, research
sponsorship payments,  interest, dividend income, proceeds of loans and sales of
securities,  sales of  inventory  and joint  venture  distributions  for general
corporate purposes.

                           6.16 Levy  Family  Repayment.  The  outstanding  Levy
family loans may be repaid in the  following  (or any less) amounts and pursuant
to the following schedule:

Precondition                          Repayment Tranche   Maximum Repayment Rate
- ------------                          -----------------   ----------------------

1.  cGMP status achieved                    $250,000          50% per month
2.  filing of injectable calcitonin IND     $250,000          50% per month
3.  filing of oral calcitonin IND           $250,000          50% per month
4.  contract with a Strategic Partner       $500,000          50% per month


                           The  repayment  of each of the  foregoing  "repayment
tranches" may not overlap. Should one such tranche become eligible for repayment
during a month  while  another  tranche  is being  repaid,  or has been  repaid,
payment of the former  shall be delayed  until the month  immediately  following
repayment in full of the latter tranche.

                           Repayment   shall  become   permissible   as  of  the
beginning of the calendar  month  immediately  following  the month in which the
specified precondition is satisfied.

                  7.       Events of Default.

                           7.1  Event of Default.  Each of the following shall
constitute an Event of Default under this Agreement, the Debentures and
Security Agreement:

                           (a) Unigene shall default in the payment of principal
         of, or any  interest  on,  the  Debentures,  when and as the same shall
         become due and payable; or

                           (b)  Unigene  shall  incur an event of default in the
         performance  of its payment  obligations  for borrowed  money under any
         note or other obligation for borrowed money in excess of $500,000 which
         has become due and payable by acceleration or otherwise; or

                           (c) any representation or warranty made by Unigene in
         this  Agreement,  the Debentures,  or the Security  Agreement or in any
         other  Document  shall prove to be false or  inaccurate in any material
         respect; or

                           (d)  Unigene  shall  default  in the  performance  or
         compliance with any covenant, condition or agreement to be performed or
         complied with by it under this Agreement or any Documents  delivered in
         connection  herewith,  and such default shall continue unremedied for a
         period of 14 consecutive  days after Unigene  receives  notice from the
         Purchasers  or  becomes  aware,  or with  the  exercise  of  reasonable
         diligence  should have been aware,  of the event of default,  provided,
         however,  if Unigene shall have commenced to remedy such default during
         such 14 day period and is diligently  seeking to remedy such default at
         the  expiration of such period,  then if the  Purchasers  are satisfied
         that, with the exercise of due diligence in the circumstances,  Unigene
         could not have  remedied  such  default in such 14 day period and that,
         with the  exercise of due  diligence,  such default is capable of being
         remedied by Unigene within a further period of 10 consecutive  days, no
         Event of Default  shall be deemed to have  occurred  under this Section
         7.1(d),   unless  such  default  is  not  remedied  to  the  reasonable
         satisfaction  of the Purchasers by the expiration of such second 10 day
         period; or

                           (e) A final  judgment for the payment of money which,
         together with all other such  undischarged  judgments,  against Unigene
         exceeds an  aggregate  of  $200,000  (after  taking  into  account  any
         proceeds from third party indemnifications and insurance proceeds which
         are paid to Unigene  with  respect to such  liability)  shall have been
         entered  against  Unigene if,  within 14 days after the entry  thereof,
         such  judgment  shall not have been  discharged  or  execution  thereon
         stayed  pending  appeal,  or if, within 14 days after the expiration of
         any such stay, such judgment shall not have been discharged; or

                           (f) A proceeding  shall have been instituted or order
         for relief shall have been made in respect of Unigene in an involuntary
         case under any applicable  bankruptcy,  insolvency or other similar law
         now or  hereafter  in effect,  or for the  appointment  of a  receiver,
         liquidator,  assignee,  custodian,  trustee,  sequestrator  (or similar
         official) of Unigene or for any  substantial  part of its property,  or
         for the winding-up or liquidation of its affairs,  and such  proceeding
         shall remain  undismissed  or unstayed and in effect for a period of 60
         consecutive  days or such court shall enter a decree of order  granting
         the relief sought in such proceeding; or

                           (g) Unigene shall commence a voluntary case under any
         applicable bankruptcy, insolvency or other similar law now or hereafter
         in effect,  or shall  consent to the entry of an order for relief in an
         involuntary   case  under  any  such  law,  or  shall  consent  to  the
         appointment  of  or  taking  possession  by  a  receiver,   liquidator,
         assignee, trustee, custodian,  sequestrator (or other similar official)
         of Unigene or for any substantial part of its property, or shall make a
         general  assignment  for the  benefit of  creditors,  or shall take any
         action in furtherance of any of the foregoing; or

                           (h) Any material  provision  of any  Document  shall,
         after execution and delivery of such Document,  for any reason cease to
         be valid and binding on Unigene,  or Unigene  shall so state in writing
         or  shall  contest  the  validity  or  enforceability  thereof,  or any
         Document shall otherwise cease to be in full force and effect,  and, in
         such case,  the  Purchasers  shall be  adversely  affected  as a result
         thereof; or

                           (i) If  Warren  Levy  and  Ronald  Levy  cease  to be
         officers of Unigene.

                           7.2  Consequences of an Event of Default.

                           (a) If an  Event  of  Default  specified  in  Section
7.1(a),  (g), or (h) shall occur,  the  outstanding  principal  of, and interest
accrued  on,  the  Debentures  and  all  other  obligations  of  Unigene  to the
Purchasers  hereunder  or  under  the  Documents  shall be  immediately  due and
payable, upon written notice from the Purchasers.

                           (b)  If an Event of Default, other than under Section
7.1(a), (g) or (h) shall occur and continue, the Purchasers, at their option, on
14 days prior written notice to Unigene,  may declare the outstanding  principal
of, and interest accrued on, the Debentures and all other obligations of Unigene
to the  Purchasers  hereunder  and under the  Documents to be forthwith  due and
payable, and the same shall thereupon become and be immediately due and payable,
without further notice of any kind.

                           (c)  Upon an  Event  of  Default  and at the time the
principal sum of the Debentures is due and payable,  the Purchasers may exercise
any one of its rights  provided to a secured party under the Uniform  Commercial
Code or other applicable law or under this Agreement,  the Security Agreement or
any one or more of the  Documents  delivered in  connection  with or pursuant to
this Agreement.

                  8. Success Fee. During the period  commencing on March 6, 1996
and ending on December  31,  1996,  Unigene  intends to raise  additional  funds
through "Funding Events" -- including, without limitation, the sale of Unigene's
convertible  debentures  pursuant to the Regulation S offering managed by Swartz
Investments LLC -- in an amount not less than $9,000,000 (the "Minimum Financing
Target").

                  As of December 31,  1998,  Unigene  shall become  obligated to
pay,  such payment to be made as provided in the last  paragraph of this Section
8, to the  Purchasers  an  amount  equal to the sum of (i) 2% of the  Enterprise
Value of Unigene as of such date plus (ii) (a) the  fraction  the  numerator  of
which is the  shortfall  between the Net Proceeds  from  Funding  Events and the
Minimum  Financing Target and the denominator of which is the Minimum  Financing
Target  multiplied by (b) 18% multiplied by (c) the Enterprise  Value of Unigene
as of such date.  Notwithstanding the foregoing,  the amounts payable by Unigene
under clause (i) of this Section 8 shall not exceed $3,000,000;  this limitation
does not apply to clause (ii) of this Section 8.

                  "Enterprise  Value" for  purposes of the  preceding  paragraph
shall equal the sum of (i) the aggregate Market Value of all outstanding  shares
of Common Stock, plus (ii) the principal amount of all outstanding long-term and
short-term  debt, less (iii) the cash held on deposit by Unigene and not subject
to pledge, lien or encumbrance.

                  Unigene  covenants  that it will  exercise  good  faith in not
attempting to manipulate  the December 31, 1998  Enterprise  Value of Unigene to
the detriment of the Purchasers.

                  The  Success  Fee shall be due as of December  31,  1998,  but
shall not be paid  until  completion  and  filing of  Unigene's  1998 Final 10-K
Annual Report with the SEC.  Final  computation of the amount of the Success Fee
shall be based on the audited financial statements included in such Final 10-K.

                  9.       Miscellaneous.

                           9.1  Notices.  All notices  and other  communications
given to or made upon any party hereto in connection with this Agreement  shall,
except  as  otherwise  expressly  herein  provided,  be  in  writing  (including
telecopied communications) and personally delivered,  mailed, telecopied or sent
by express courier to the respective parties as follows:

                                    if to Unigene, to:

                                    Unigene Laboratories, Inc.
                                    110 Little Falls Road
                                    Fairfield, NJ  07004
                                    Attn:  Warren Levy

                                    if to the Purchasers, to:

                                    Olympus Securities, Ltd.
                                    c/o Leeds Management Ltd.
                                    129 Front Street
                                    Hamilton HM 12 Bermuda
                                    Attention:  Nitin Aggarwal
                                    Telecopier No.:  441-292-2239

                                                   and

                                    Nelson Partners
                                    c/o Citadel Investment Management, L.P.
                                      Citadel Investment Management, Inc.
                                      Leeds Management Ltd.
                                    129 Front Street
                                    Hamilton HM 12 Bermuda
                                    Attention:  Nitin Aggarwal
                                    Telecopier No.:  441-292-2239

or in accordance with any subsequent  written direction from the recipient party
to the sending party. All such notices and other communications shall, except as
otherwise expressly herein provided, be effective upon delivery, if delivered by
hand;  two days after deposit in the mail, if sent by  registered  mail,  return
receipt  requested,  postage prepaid;  in the case of telecopy,  when the answer
back is received;  or if sent by express courier  providing  guaranteed next day
delivery, on the next succeeding Business Day.

                           9.2 Costs.  Unigene will pay (i) the reasonable  fees
and expenses of counsel for the Purchasers in connection with the preparation of
the Documents and any waiver,  consent or release by the Purchasers under any of
the Documents,  any amendment thereof, or any Event of Default,  and (ii) if the
Purchasers  shall incur  costs  and/or  expenses to collect,  enforce or protect
their rights under this Agreement or any of the Documents, Unigene shall pay all
of the  reasonable  costs  and  expenses  of such  collection,  enforcement  and
protection,  including reasonable  attorneys' fees, of the Purchasers.  Whenever
counsel fees are provided for in this Agreement or any of the  Documents,  it is
understood and agreed that the interests of the Purchasers  (and/or holders) are
substantially  similar and that there shall be no  allowance of counsel fees for
separate counsel of each of the Purchasers (and/or holders).

                           9.3  Representations to Survive.  All representations
and  warranties  contained  herein or in any other  Document  made or  delivered
pursuant  hereto  or  thereto  or to be  executed  and  delivered  hereunder  or
thereunder,  shall be deemed to survive (a) the  execution  and delivery of this
Agreement and the Documents  and (b) any  investigation  made by or on behalf of
the  Purchasers  at  any  time  while  any  amounts  under  the  Debentures  are
outstanding.

                           9.4  Purchased Warrants to Survive.  The terms of the
Purchased  Warrants  shall remain in full force and effect  irrespective  of the
transactions  contemplated  hereby  (except as provided  in  Sections  2.2.6 and
2.2.12).

                           9.5  Successors  and  Assigns.  All  representations,
warranties  and  covenants  in this  Agreement  by or on  behalf  of, or for the
benefit  of any of the  parties  hereto,  shall be  binding  on and inure to the
benefit  of  such   party,   its   successors   and   assigns.   The   foregoing
notwithstanding,  this  Agreement,  the  Debentures,  and the other  agreements,
documents  and  instruments  entered in or delivered in  connection  herewith or
therewith  may not be assigned,  in whole or in part and in fact or by operation
of law, by Unigene without the prior written approval of the Purchasers.

                           9.6 Stamp or Other Tax.  Should any stamp,  recording
tax or fee or other similar tax become  payable with respect to this  Agreement,
the  Debentures,  the Security  Agreement,  the Warrants or any other  document,
Unigene promptly following demand therefor will pay the same. This section shall
not apply to any income or  withholding  taxes or  transfers  by  Purchasers  or
holders.

                           9.7  Cumulative  Remedies.  No failure on the part of
any Purchaser to exercise, and no delay in exercising,  any remedy, right, power
or privilege  hereunder,  or under any other  agreement,  security or instrument
delivered  pursuant  hereto,  shall operate as a waiver  thereof;  nor shall any
single  or  partial  exercise  of any such  remedy,  right,  power or  privilege
preclude any other or further exercise of any other such remedy, right, power or
privilege,  and no waiver  whatsoever shall be valid unless in writing signed by
the  Purchasers  and then  only to the  extent  specifically  set  forth in such
writing.  All remedies,  rights,  powers and privileges  afforded the Purchasers
under this  Agreement,  the  Debentures and any other  agreements,  documents or
instruments  delivered in connection  herewith or therewith  shall be cumulative
and not be exclusive of any remedies, rights, powers and privileges available by
law and shall be available until the Debentures and all interest thereon and all
other  indebtedness  of Unigene to the  Purchasers  have been paid in full.  The
Purchasers may exercise any such remedies,  rights, powers and privileges in any
order or priority.

                           9.8  Severability.  In  case  any  one or more of the
provisions of this Agreement or the Documents shall be held invalid,  illegal or
unenforceable in any respect,  the validity,  legality and enforceability of the
remaining  provisions  hereof and  thereof  shall not be  affected  or  impaired
thereby.

                           9.9 Governing  Law. This Agreement and the rights and
obligations  of the  parties  hereto  shall  be  governed  by and  construed  in
accordance  with the laws of the State of New  York,  except  that the  Security
Agreement and Mortgage shall be governed by the laws of the state of New Jersey.

                           9.10 Sole Agreement;  Amendments. It is the intention
of the parties that this Agreement and the Documents  shall  supersede any prior
negotiations,  discussions, commitments,  representations or agreements, written
or oral,  other  than as  specified  herein,  including  but not  limited to any
correspondence,  conversations,  discussions,  representations or other means of
communication not specified or set forth herein.  No amendment,  modification or
waiver of any provision of this  Agreement,  nor consent to any departure by any
party  herefrom,  shall in any event be  effective  unless  the same shall be in
writing and signed by the party to be charged and then such amendment, waiver or
consent  shall be effective  only in the specific  instance and for the specific
purpose for which given.

                           9.11  Captions.  The headings of the Sections of this
Agreement have been inserted  solely for  convenience of reference and shall not
modify, define or limit the express provisions of this Agreement.

                           9.12 Waiver. The waiver by a party of a breach of any
provision of this Agreement or any Document shall not operate or be construed as
a waiver of any subsequent breach by any party.

                           9.13 Right of the Purchasers to Perform Covenants. If
Unigene  fails or refuses to perform or comply with any  covenant,  condition or
agreement  to be  performed  or  complied  by it  under  any  provision  of this
Agreement  or any other  Document to which it is a party,  Purchasers  may,  but
shall not be obligated to, perform or comply with such provision for the account
of and at the expense of such Person,  and Unigene will,  jointly and severally,
on demand,  reimburse  Purchasers for all costs and expenses paid or incurred by
them in  performing  or complying  with such  provision,  together  with accrued
interest  thereon  at the rate of 11.5%  per  annum  from the time  such cost or
expense was paid or incurred and payment  demanded  until the same is reimbursed
in full to Purchasers.

                           9.14  No  Brokerage  or  Finder's  Fees.  Each  party
represents and warrants that it has dealt with no broker or finder in connection
with the transactions  contemplated  hereby. Each party shall indemnify and save
the other  harmless  from any and all claims for  broker's or  finder's  fees or
commissions  which arise out of any agreement  made by such  indemnifying  party
with respect to the subject matter of this Agreement.

                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Agreement to be duly executed, as of the day and year first above written.

                                                     UNIGENE LABORATORIES, INC.



                                   By:________________________________
                                      Name:
                                     Title:


                            OLYMPUS SECURITIES, LTD.



                                   By:________________________________
                                      Name:
                                     Title:


                                 NELSON PARTNERS

                                   By: CITADEL INVESTMENT
                                       MANAGEMENT, L.P.,
                                       General Partner

                                   By:  CITADEL INVESTMENT MANAGEMENT,
                                        INC., General Partner


                                   By:________________________________
                                      Name:
                                     Title: