Schedule 10.20
                                 --------------


Exhibit  10.20 is the form of  Regulation  S Securities  Subscription  Agreement
entered into by the Company and each of 22 subscribers for the sale and purchase
of an  aggregate  principal  amount  of  $9.08  million  of  the  Company's  10%
Convertible  Debentures  due March 4, 1999.  All such  executed  agreements  are
identical  except for the identity of the subscriber and the principal amount of
debentures purchased.






                                  EXHIBIT 10.20





                           UNIGENE LABORATORIES, INC.

                 REGULATION S SECURITIES SUBSCRIPTION AGREEMENT

         THE  DEBENTURES  BEING  SUBSCRIBED  FOR  HEREIN  AND THE  COMMON  STOCK
ISSUABLE UPON  CONVERSION OF THE DEBENTURES  HAVE NOT BEEN  REGISTERED  WITH THE
UNITED STATES SECURITIES AND EXCHANGE  COMMISSION ("THE  COMMISSION")  UNDER THE
U.S.  SECURITIES  ACT OF  1933,  AS  AMENDED,  (THE  "ACT")  OR  THE  SECURITIES
COMMISSION OF ANY STATE UNDER ANY STATE  SECURITIES  LAW. THEY ARE BEING OFFERED
PURSUANT TO A SAFE HARBOR FROM REGISTRATION  UNDER REGULATION S ("REGULATION S")
PROMULGATED UNDER THE ACT . THE SECURITIES MAY NOT BE OFFERED, SOLD OR OTHERWISE
TRANSFERRED IN THE UNITED STATES OR TO A U.S. PERSON (AS SUCH TERM IS DEFINED IN
REGULATION S) UNLESS THE SECURITIES ARE REGISTERED  UNDER THE ACT AND APPLICABLE
STATE SECURITIES LAWS, OR SUCH OFFERS,  SALES AND TRANSFERS ARE MADE PURSUANT TO
AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THOSE LAWS.

         THIS SUBSCRIPTION  AGREEMENT DOES NOT CONSTITUTE AN OFFER TO SELL, OR A
SOLICITATION  OF AN OFFER TO BUY, ANY OF THE  SECURITIES  OFFERED  HEREBY TO ANY
PERSON  IN ANY  JURISDICTION  IN  WHICH  SUCH  OFFER  OR  SOLICITATION  WOULD BE
UNLAWFUL.  INVESTMENT  IN SUCH  SECURITIES  INVOLVES A HIGH  DEGREE OF RISK.  IN
MAKING AN INVESTMENT  DECISION,  INVESTORS MUST RELY ON THEIR OWN EXAMINATION OF
THE COMPANY AND THE TERMS OF THE  OFFERING,  INCLUDING  THE MERITS AND THE RISKS
INVOLVED. THESE SECURITIES HAVE NOT BEEN RECOMMENDED, APPROVED OR DISAPPROVED BY
ANY U.S.  FEDERAL  OR  STATE  SECURITIES  COMMISSION  OR  REGULATORY  AUTHORITY.
FURTHERMORE, THE FOREGOING AUTHORITIES HAVE NOT REVIEWED, PASSED UPON, CONFIRMED
OR  DETERMINED  THE  ACCURACY OR ADEQUACY  OF THIS  DOCUMENT OR ANY  INFORMATION
PROVIDED  BY THE  COMPANY TO  POTENTIAL  INVESTORS.  ANY  REPRESENTATION  TO THE
CONTRARY IS A CRIMINAL OFFENSE.

         This Securities Subscription Agreement (the "Agreement") is executed by
the  undersigned  (the  "Subscriber")  in  connection  with  the  offering  (the
"Offering") and  subscription by the undersigned for 10% Convertible  Debentures
(the "Debentures") of Unigene Laboratories,  Inc. (the "Company"),  due on March
4, 1999, and offered in denominations of at least $50,000 and integral multiples
of  $10,000  in excess  thereof up to a maximum  aggregate  principal  amount of
$9,080,000.  The  terms of the  Debentures,  including  the  terms on which  the
Debentures  may be converted into common stock,  $.01 par value,  of the Company
(the  "Common  Stock"),  are set forth in the  Debenture,  in the form  attached
hereto as Exhibit A. The solicitation of this  subscription  and, if accepted by
the Company, sale of Debentures,  are being made in reliance upon the provisions
of  Regulation  S. The  Company may be subject to NASD  regulatory  restrictions
regarding  the  number  of  shares  that may be issued  upon  conversion  of the
Debentures  (see Section 6.13 below and the Risk Factors  referred to in Section
2.3). The  Debentures,  and the shares of Common Stock issuable upon  conversion
thereof (the  "Shares"),  are sometimes  referred to herein  collectively as the
"Securities."  The  Subscriber  wishes to subscribe for Debentures in the amount
set forth in Section 19 in accordance  with the terms and conditions of the form
of Debenture and this Agreement. It is agreed as follows:


1.       Offer to Subscribe; Purchase Price; Closing; Placement Fees; and
Conditions to
          Subscriber's Obligations.

         1.1 Offer to Subscriber; Purchase Price. Subject to satisfaction of the
         conditions to closing set forth below, the Subscriber hereby subscribes
         for and agrees to purchase the aggregate principal amount of Debentures
         for a purchase price set out in Section 19 of this Agreement.

         1.2  Closing.  The closing of the sale and  purchase of the  Debentures
         ("Closing")  will occur  upon (i) the  satisfaction  of all  conditions
         described  in this  Agreement,  (ii) sale in this  Offering of at least
         $6,000,000 of aggregate  principal  amount of Debentures  (the "Minimum
         Amount"),  and no more than $9,080,000 of aggregate principal amount of
         Debentures (the "Maximum  Amount"),  and (iii) the  satisfaction of all
         conditions  required  by  the  Escrow  Agreement  ("Escrow  Agreement",
         defined as the agreement between the Company,  Swartz Investments,  LLC
         ("Placement  Agent ") and First Union  National Bank  ("Escrow  Agent")
         regarding this Offering). As soon as the subscriptions for at least the
         Minimum  Amount have been  accepted by the  Company,  according  to the
         terms of this Agreement, the Company shall close on the Minimum Amount.
         Thereafter,  the Company may  conduct one or more  additional  Closings
         until the Maximum Amount has been reached.

         1.3 Placement Fees. The parties hereto  acknowledge  that the Placement
         Agent for this Offering will be  compensated by the Company in cash and
         warrants to purchase  Common Stock of the Company.  The Placement Agent
         has acted solely as placement  agent in connection with the Offering by
         the  Company  of  the  Debentures  pursuant  to  this  Agreement.   The
         information and data contained in the Disclosure  Documents (as defined
         in Section  2.2  below) and Risk  Factors  (as  defined in Section  2.3
         below) have not been subjected to independent verification by Placement
         Agent, and no  representation or warranty is made by Placement Agent as
         to the accuracy or  completeness  of the  information  contained in the
         Disclosure Documents and Risk Factors.

         1.4  Conditions to Subscriber's Obligations.  The Subscriber's
         obligations hereunder are further conditioned upon the following:

                  (i) the Common Stock is listed on the National  Association of
                  Securities  Dealers,  Inc.'s NASDAQ  National Market System or
                  Small Cap Market ("Nasdaq");

                  (ii) the  representations  and  warranties  of the Company are
                  true and correct in all material  respects on the Closing Date
                  as if made on such  date,  and the  Company  shall  deliver  a
                  certificate, signed by an officer of a Company, to such effect
                  to the Escrow Agent;

                  (iii)  there  have been no  material  adverse  changes  in the
                  Company's business prospects or financial  condition since the
                  date of the Company's  balance sheet dated September 30, 1995;
                  and

                  (iv) the following  documents  shall have been  deposited with
                  the Escrow  Agent:  the  Registration  Rights  Agreement,  the
                  Opinion of Counsel and the Debenture;

2.       Representations and Covenants; Access to Information; Independent
         Information; Independent Investigation

         2.1      Offshore Transaction.

                  The Subscriber represents and warrants to the Company that (i)
                  the  Subscriber is not a U.S.  person ("U.S.  person") as that
                  term is  defined  in Rule  902(o) of  Regulation  S (a copy of
                  which   definition   is  attached  as  Exhibit  B)  and  which
                  definition  includes,  without  limitation,  a corporation  or
                  partnership that is organized under the laws of a jurisdiction
                  other than the United States if it is formed by a U.S.  person
                  principally  for the purpose of  investing in  securities  not
                  registered   under  the  Act,   unless  it  was  organized  or
                  incorporated,  and  is  owned,  by  accredited  investors  (as
                  defined in Rule 501(a) of  Regulation D under the Act) who are
                  not natural  persons,  estates or trusts;  (ii) the Securities
                  were not offered to the Subscriber in the United States and at
                  the time of execution of this  Subscription  Agreement and the
                  time of any offer to the Subscriber to purchase the Securities
                  hereunder,  the Subscriber  was physically  outside the United
                  States;  (iii) the Subscriber is purchasing the Securities for
                  its own account and not on behalf of or for the benefit of any
                  U.S. person and the sale and resale of the Securities have not
                  been  prearranged  with any U.S. person or buyer in the United
                  States;  (iv) the Subscriber  agrees,  and to the knowledge of
                  the Subscriber,  without any independent  investigation,  each
                  distributor,  if any,  participating  in the  offering  of the
                  Securities,  has  agreed,  that all  offers  and  sales of the
                  Securities  prior to the expiration of a period  commencing on
                  the  date  of the  last  Closing  of a sale  and  purchase  of
                  Debentures  pursuant to the Offering (the "Last  Closing") and
                  ending forty days thereafter (the  "Restricted  Period") shall
                  not be made to U.S.  persons or for the  account or benefit of
                  U.S.  persons and shall  otherwise be made in compliance  with
                  the  provisions of Regulation S; and (v)  Subscriber is not an
                  underwriter,  dealer,  distributor  or  other  person  who  is
                  participating,  pursuant to a contractual arrangement,  in the
                  distribution of the Securities  offered or sold in reliance on
                  Regulation S.

         2.2      Subscriber's  Independent  Investigation.  The Subscriber,  in
                  offering to subscribe for the Securities hereunder, has relied
                  solely upon (i) an  independent  investigation  made by it and
                  its  representatives,  if any,  and (ii)  the  representation,
                  warranties and disclosures of the Company set forth herein and
                  in the  Disclosure  Documents (as defined  below).  Subscriber
                  has, prior to the date hereof,  been given the  opportunity to
                  examine all material  contracts  and  documents of the Company
                  which have been filed as  exhibits  to the  Company's  filings
                  made under the Act and the Securities Exchange Act of 1934, as
                  amended  (the  "Exchange   Act").  In  making  its  investment
                  decision to purchase the  Debentures,  the  Subscriber  is not
                  relying on any oral or written  representations  or assurances
                  from the Company or any other  person  other than as set forth
                  in this  Agreement,  or on any  information  other  than  that
                  contained or  incorporated  by reference in this Agreement and

                  in written  information,  if any,  prepared by the Company and
                  supplied  to the  Subscriber  by  the  Company  in  connection
                  herewith or in the  Company's (i) Annual Report on Form 10-KSB
                  for the year ended December 31, 1994 and (ii) Quarterly Report
                  on Form  10-QSB  for the  quarter  ended  September  30,  1995
                  (collectively, the "Disclosure Documents"). The Subscriber has
                  such  experience in business and financial  matters that it is
                  capable  of  evaluating   the  risk  of  its   investment  and
                  determining the suitability of its investment.  The Subscriber
                  is an accredited investor as defined in Rule 501 of Regulation
                  D, a copy of which definition is attached hereto as Exhibit C.
                  
         2.3      Subscriber's  Economic Risk. The  Subscriber  understands  and
                  acknowledges  that an investment in the Securities  involves a
                  high degree of risk.  Subscriber  acknowledges  that there are
                  limitations on the liquidity of the Securities. The Subscriber
                  represents  that the  Subscriber  is able to bear the economic
                  risk of an investment in the Securities,  including a possible
                  total  loss  of  investment.  In  making  this  statement  the
                  Subscriber  hereby represents and warrants to the Company that
                  the  Subscriber  has  adequate  means  of  providing  for  the
                  Subscriber's current needs and contingencies;  that Subscriber
                  is able to afford  to hold the  Securities  for an  indefinite
                  period;  and that Subscriber has such knowledge and experience
                  in financial  and  business  matters  that the  Subscriber  is
                  capable of evaluating  the merits and risks of the  investment
                  in the Securities.  Further, the Subscriber represents,  as of
                  the date of signing this Agreement, that the Subscriber has no
                  present  need  for  liquidity  in  the   Securities   and  the
                  Subscriber  is  willing  to  accept  such  investment   risks.
                  Subscriber  has reviewed the Disclosure  Documents,  including
                  without  limitation  the Risk  Factors set forth at Exhibit D,
                  prior to subscribing for any Debentures.

         2.4      No  Government  Recommendation  or  Approval.  The  Subscriber
                  understands that no United States federal or state agency,  or
                  similar agency of any other country,  has reviewed,  approved,
                  passed upon or made any  recommendation  or endorsement of the
                  Company, the Offering or the subscription for the Securities.

         2.5      No Directed Selling Efforts in Regard to this Transaction.  To
                  the  knowledge  of the  Subscriber,  without  any  independent
                  investigation,  neither the Company,  Placement  Agent nor any
                  other distributor (if any) participating in the Offering,  nor
                  any person acting for the Company, Placement Agent or any such
                  distributor,  has conducted any "directed  selling efforts" in
                  the United States as the term  "directed  selling  efforts" is
                  defined in Rule  902(b) of  Regulation  S,  which in  general,
                  means any  activity  undertaken  for the  purpose  of, or that
                  could   reasonably   be   expected  to  have  the  effect  of,
                  conditioning  the market in the  United  States for any of the
                  Securities  being  offered in reliance on  Regulation  S. Such
                  activity includes,  without limitation, the mailing of printed
                  material  to  investors  residing  in the United  States,  the
                  holding of promotional  seminars in the United States, and the
                  placement of advertisements  with radio or television stations
                  broadcasting  in the United States or in  publications  with a
                  general  circulation in the United States,  that refers to the
                  offering of the Securities in reliance on Regulation S.

         2.6      Company's  Reliance on  Representations  of Subscribers.  This
                  Agreement  is made by the  Company  with  each  Subscriber  in
                  reliance upon such Subscriber's  representations and covenants
                  made in this  Section 2,  which  reliance  by his,  her or its
                  execution of this Agreement the Subscriber hereby confirms.

         2.7      Securities  Not  Registered  Under the Act or Any  State  Act.
                  Subscriber  understands  that the  Debentures  and the  Common
                  Stock issuable upon conversion of the Debentures have not been
                  registered  under the Act or any state securities laws ("State
                  Acts") and are being offered and sold pursuant to Regulation S
                  based in part upon the representations of Subscriber contained
                  herein.  The  Common  Stock  does,   however,   carry  certain
                  registration  rights as set forth in the  Registration  Rights
                  Agreement,  in the form of Exhibit Q (see  Section  7.4 below)
                  executed by the parties hereto.

         2.8      No  Public   Solicitation.   Subscriber  knows  of  no  public
                  solicitation or  advertisement  of an offer in connection with
                  the proposed issuance and sale of the Securities.

         2.9      Investment  Intent.  Subscriber is acquiring the Debentures to
                  be issued and sold  hereunder  (and the Shares  issuable  upon
                  conversion of the  Debentures) for his, her or its own account
                  (or a trust  account  if such  Subscriber  is a  trustee)  for
                  investment  and not as a  nominee  and not  with a view to the
                  distribution thereof.  Subscriber  understands that Subscriber
                  must bear the economic  risk of this  investment  indefinitely
                  unless such Debentures or such Shares are registered  pursuant
                  to the Act and any applicable State Acts, or an exemption from
                  such  registration  is available,  and that the Company has no
                  present   intention  of  registering  any  such  sale  of  the
                  Debentures  or  Shares  other  than  as  contemplated  by  the
                  Registration  Rights  Agreement.   Subscriber  represents  and
                  warrants  to the  Company,  as of the date of this  Agreement,
                  that  Subscriber  has no present plan or intention to sell the
                  Debentures   or  the  Shares  in  the  United  States  at  any
                  predetermined time, and has made no predetermined arrangements
                  to sell the  Debentures  or the Shares.  Subscriber  covenants
                  that  neither  Subscriber  nor its  affiliates  nor any person
                  acting  on its or  their  behalf  has  entered  into,  has the
                  intention of entering into, or will enter into any put option,
                  short   position  or  other  similar   instrument,   contract,
                  arrangement  or position  with  respect to the  Debentures  or
                  Common Stock of the Company  anytime  after the earlier of (i)
                  the time  Subscriber  first received the term sheet (the "Term
                  Sheet")  concerning  this  Offering  and (ii)  the  time  that
                  Subscriber  was  first  notified  by  Placement  Agent  of the
                  existence of the Offering (the earlier of which is referred to
                  as the "Time of Notification  of the Offering")  until the end
                  of the  Restricted  Period,  or at any time  for the  intended
                  purpose  of  lowering  the price at which the  Debentures  are
                  convertible into Shares; and neither Subscriber nor any of its
                  affiliates  nor any person  acting on its or their behalf will
                  at  any  time  use  Shares  acquired  upon  conversion  of the
                  Debentures to settle/cover  any put option,  short position or
                  other similar  instrument,  contract,  arrangement or position
                  entered into prior to the end of the Restricted Period.

         2.10     Subscriber Not to Sell or Transfer  Securities in Violation of
                  the Securities Laws.  Subscriber  covenants that he, she or it
                  will  not   knowingly   make  any  sale,   transfer  or  other
                  disposition  of the  Debentures  or the Shares in violation of
                  the Act  (including  Regulation  S),  the  Exchange  Act,  any
                  applicable  State  Acts or the  rules and  regulations  of the
                  Commission or of any state  securities  commissions or similar
                  state authorities promulgated under any of the foregoing.

         2.11     Subscriber's  Power  and  Authority.  Subscriber  has the full
                  power and  authority  to execute,  deliver  and  perform  this
                  Agreement.  This  Agreement,  when  executed and  delivered by
                  Subscriber,  will  constitute  a  valid  and  legally  binding
                  obligation of Subscriber,  enforceable in accordance  with its
                  terms.

         2.12     Signatory's Representation.  The signatory to this Agreement
                  hereby represents and warrants that he, she or it is either:

                  (a) not a U.S. person (as defined in Regulation S), and is not
                  located in the U.S. at the time of signing this Agreement, or

                  (b) a professional fiduciary of Subscriber (as described in
                  Section (o)(2) through
                   (o)(4) of Rule 902 of  Regulation  S),  acting  solely in his
                  capacity as holder of such account, as a fiduciary,  executor,
                  administrator,  or trustee,  and has  completed and signed the
                  accompanying  Certificate  (Exhibit  E)  and  forwarded  it to
                  Placement Agent.

         2.13     No Tax Advice From Company or Its Agents.  Subscriber  has had
                  an opportunity to review with his, her or its own tax advisors
                  the foreign, U.S. federal, state and local tax consequences of
                  this  investment,  and the  transactions  contemplated by this
                  Agreement.  Subscriber is relying  solely on such advisors and
                  not on any statements or representations of the Company or any
                  of its agents and  understands  that  Subscriber  (and not the
                  Company) shall be  responsible  for the  Subscriber's  own tax
                  liability that may arise as a result of this investment or the
                  transactions contemplated by this Agreement.

         2.14     No  Legal  Advice  from  Company  or  Its  Agents.  Subscriber
                  acknowledges  that he, she, or it has had the  opportunity  to
                  review this  Agreement and the  transactions  contemplated  by
                  this  Agreement  with his,  or her or its own  legal  counsel.
                  Subscriber  is relying  solely on such  counsel and not on any
                  statements  or  representations  of the  Company or any of its
                  agents for legal advice with respect to this investment or the
                  transactions  contemplated by this  Agreement,  except for the
                  representations, warranties and covenants set forth herein and
                  on the opinion provided for in paragraph 7.3 herein.

         2.15     Offering Material Statements. Subscriber acknowledges that all
                  offering  materials and documents received by it in connection
                  with  the  offers  and  sales  of  the   Securities   included
                  statements  to the  effect  of those  contained  in the  first
                  legend set forth on the first page of this Agreement

         2.16     No Scheme to Evade Registration.  Subscriber's  acquisition of
                  the  Debentures  is not a  transaction  (or any  element  of a
                  series  of  transactions)  that is part of a plan or scheme to
                  evade the registration provisions of the Act.

3.  Resales of Securities by Subscriber

                  Subscriber   acknowledges,   covenants  and  agrees  that  the
Securities may and will only be resold by it (a) in compliance with Regulation S
and  applicable  State  Acts,  if any;  or (b)  pursuant  to an  exemption  from
registration  under the Act and  applicable  State  Acts  after  the  Restricted
Period; or (c) pursuant to an effective and current Registration Statement under
the Act.  In  addition,  in  connection  with any  resale of the  Debentures  in
accordance  with clause (a) or (b),  above,  the Subscriber  will deliver to the
Company and will cause the  purchaser  to deliver to the  Company the  documents
described in Section 3.1 and 3.2 below, respectively:

         3.1.     Documents to be Delivered  for Offshore  Regulation S Resales.
                  If any  Debenture is being resold to an offshore  purchaser in
                  compliance with Regulation S:

                           1. Sales  Agreement,  executed by Subscriber  and the
                  purchaser (in the form of Exhibit F);
                           2.  Seller  Representation  Letter  (in  the  form of
                  Exhibit G);
                           3. Assignment  Separate from Certificate (in the form
                  of Exhibit H)(or endorsed Certificates);
                           4.  Seller's  Instruction  Letter  (in  the  form  of
                  Exhibit  I); and 
                           5.  Purchaser  Representation  Letter (in the form of
                  Exhibit J).

         3.2      Documents to be Delivered for Resales into the United  States.
                  If any  Debenture  is being  resold to a purchaser in the U.S.
                  after the Restricted Period:

                           1. Sales  Agreement,  executed by both Subscriber and
                  the purchaser (in the form of Exhibit F);

                           2.  Seller  Representation  Letter  (in  the  form of
                  Exhibit K);

                           3. Assignment  Separate from Certificate (in the form
                  of Exhibit H)(or endorsed Certificates);

                           5.  Seller's  Instruction  Letter  (in  the  form  of
                  Exhibit I); and

                           6.  Purchaser  Representation  Letter (in the form of
                  Exhibit J).

         Upon receipt of the executed  documents  listed above, the Company will
effect the transfer of the Debentures on the Company's  books and will issue and
deliver new  Debentures  in the  purchaser's  name (and, in the case of a resale
pursuant to Section 3.2 after the  Restricted  Period,  free of any  restrictive
legend  restricting  transfer  under the Act) within three (3) business  days of
such  receipt.  The  provisions  of this Section 3 shall not apply to subsequent
resales of Debentures that have previously been sold by Subscriber in compliance
with this Section 3.

4.  Legends; Subsequent Sale of Securities

         4.1      Debenture   Legend.   The   Debenture   shall  bear  a  legend
                  substantially in the form of the first legend set forth on the
                  first page of this  Agreement  (the  "Regulation S Restrictive
                  Legend")  and  any  other  legend  or  legends  as  reasonably
                  required to comply with U.S. federal, state or foreign law.

         4.2      The  Shares  Obtained  Upon   Conversion   Shall  Not  Bear  a
                  Restrictive Legend.  Assuming that there are no changes in the
                  material  facts set forth in  Section 2 of this  Agreement  or
                  applicable  law  from  the  date  hereof  until  the  Date  of
                  Conversion (as that term is defined in the  Debentures) of the
                  Debentures  by   Subscriber,   the  Shares   obtained  upon  a
                  conversion  after  the  Restricted  Period  shall not bear any
                  restrictive  legend  restricting  transfer  under the Act, nor
                  shall any stop  order be  placed on the books of the  Transfer
                  Agent,  provided that the Subscriber delivers to the Company a
                  Certificate in the form of Exhibit L.

         4.3      Removal of Debenture  Legend for Pledge With a Margin Account.
                  Upon the  submission,  at any time after the expiration of the
                  Restricted  Period,  by  Subscriber  of a written  request for
                  removal of the Regulation S Restrictive Legend for the purpose
                  of a bona fide pledge or deposit of  Debentures  with a margin
                  account, together with the Debentures for which legend removal
                  is being requested and a Certificate in the form of Exhibit M,
                  the Company shall immediately  re-issue the Debentures without
                  any restrictive legend restricting  transfer under the Act, or
                  the Company shall irrevocably instruct its designated transfer
                  agent ("Transfer  Agent") to do so, assuming that there are no
                  changes in the  material  facts set forth in Section 2 of this
                  Agreement  or  applicable  law from the date hereof  until the
                  date of such submission. Except for the requirements otherwise
                  set forth in this Agreement, and assuming there are no changes
                  after  the date  hereof  in the  material  facts  set forth in
                  Section 2 of the Agreement or applicable  law, no action other
                  than as set forth in this Section 4.3 shall be required of the
                  Subscriber  to remove  the  Regulation  S  Restrictive  Legend
                  (unless such pledge or deposit would constitute a violation of
                  securities law).

         4.4      The Company's Instructions to Transfer Agent. The Company will
                  issue to its Transfer Agent an irrevocable  instruction letter
                  (the "Irrevocable  Instructions to Transfer Agent") to convert
                  the  Subscriber's  Debentures  to Common Stock (in  accordance
                  with the  Debenture  and,  so long as Section  4.2 is complied
                  with,  free of any  restrictive  legend  restricting  transfer
                  under the Act) upon  receipt of a valid  Notice of  Conversion
                  from a Subscriber and the original Debentures,  and such other
                  documents as are required by this Agreement or the Debenture.

5.       Issuance of Securities in the Near Future; Notice Requirements

         The Company shall not issue any debt or equity  securities  for cash in
         private capital raising transactions  ("Future Offerings") for a period
         of seventy five (75) days after the Last Closing without  obtaining the

         prior  written  approval  of  Subscribers  holding  a  majority  of the
         principal  amount of  Debentures  then  outstanding,  provided that the
         preceding  shall  not  limit the  Company's  right to  conduct a public
         secondary  offering.  The Company will not conduct any Future Offerings
         for a period of two hundred and forty (240) days after the Last Closing
         without delivering to the Subscriber prior written notice of its intent
         to conduct a Future Offering (a "Future Offering Notice") setting forth
         the material terms of the proposed Future Offering. For a period of ten
         (10) days,  commencing  on the date of receipt of such Future  Offering
         Notice  (the  "Offer  Period"),  the  Subscriber  shall  have the right
         irrevocably  to commit to purchase  the  Subscriber's  Portion (as that
         term is defined  below) of the  securities  being offered in the Future
         Offering on the terms  contained  in the Future  Offering  Notice.  If,
         during the Offer Period,  the Subscriber fails irrevocably to commit to
         purchase  the  Subscriber's  Portion  of the  securities  that  are the
         subject of the Future Offering  Notice,  the Company shall be permitted
         to  offer  and sell any such  securities,  on terms  generally  no less
         favorable  to the  Company  than are set forth in the  Future  Offering
         Notice,  to any  third  party  during  a period  of  ninety  (90)  days
         following the termination of the Offer Period after which 90 day period
         the terms of this Section 5 shall again apply (the limitations referred
         to in the  preceding  sentences  of  this  Section  5 are  collectively
         referred to as the "Capital Raising  Limitation").  The Capital Raising
         Limitation  shall not apply to any transaction  involving the Company's
         commercial   banking   arrangements   or  issuances  of  securities  in
         connection  with a  merger,  consolidation  or  sale of  assets,  or in
         connection  with or as part of the same  transaction as a joint venture
         or other  acquisition  or  disposition  of a  business,  a product or a
         license  by  the  Company,   or  exercise  of  options  by   employees,
         consultants or directors or any transaction with a strategic  corporate
         partner or to loan  securitization  or sales of loans to master trusts.
         The Capital Raising  Limitation also shall not apply to the issuance of
         securities  upon  exercise  or  conversion  of the  Company's  options,
         warrants or other  convertible  securities  outstanding  as of March 5,
         1996,  or to the  grant  of  additional  options  or  warrants,  or the
         issuance of  additional  securities,  under any Company stock option or
         restricted  stock plan. The amount of securities  which a Subscriber is
         entitled  to  purchase  in such a Future  Offering  (the  "Subscriber's
         Portion")  shall be a number  obtained  by  multiplying  the  aggregate
         amount  of  securities  being  offered  in  the  Future  Offering  by a
         fraction,  the numerator of which is the aggregate  principal amount of
         Debentures  purchased by the Subscriber  pursuant to this Agreement and
         the  denominator  of  which  is  the  aggregate   principal  amount  of
         Debentures placed in the Offering.  If the Company fails to obtain from
         purchasers  of Debentures in the Offering  irrevocable  commitments  to
         purchase  90% of the proposed  Future  Offering,  the Company  shall be
         released from any  obligation  under this Section 5 to the  Subscribers
         with respect to such Future Offering.

6.       Representations and Warranties of Company

         Company represents and warrants to Subscriber as follows:

         6.1      Organization, Good Standing, and Qualification. The Company is
                  a corporation  duly  organized,  validly  existing and in good
                  standing  under  the  laws of state  of  Delaware  and has all
                  requisite  corporate  power  and  authority  to  carry  on its
                  business as now conducted and as proposed to be conducted. The
                  Company is duly qualified to transact  business and is in good
                  standing  in each  jurisdiction  in which  the  failure  to so
                  qualify would have a material  adverse  effect on the business
                  or properties of the Company and its  subsidiaries  taken as a
                  whole.  The Company,  is not the subject of any pending or, to
                  its knowledge,  threatened  investigation or administrative or
                  legal proceeding by the Internal  Revenue Service,  the taxing
                  authorities  of  any  state  or  local  jurisdiction,  or  the
                  Securities and Exchange Commission which could have a material
                  adverse  effect  and  which  have  not been  disclosed  in the
                  reports referred to in Section 2.2 above.

         6.2      Corporate  Condition.  The  Company's  condition  was,  in all
                  material respects, as described in the Disclosure Documents at
                  the  respective  dates  thereof.  There  has been no  material
                  adverse change in the Company's business  financial  condition
                  or  prospects   since   September  30,  1995.  The  Disclosure
                  Documents are true and correct, in all material respects,  and
                  the financial statements contained in the Disclosure Documents
                  have been  prepared  in  accordance  with  generally  accepted
                  accounting   principles,   consistently  applied,  and  fairly
                  present the  financial  position and results of operation  and
                  cash flows of the  Company on a  consolidated  basis,  for the
                  periods then ended. Without limiting the foregoing,  there are
                  no material  liabilities,  contingent or actual,  that are not
                  disclosed in the  Disclosure  Documents.  The Company has paid
                  all  material  taxes which are due,  except for taxes which it
                  reasonably disputes.  There is no material claim,  litigation,
                  or administrative  proceeding  pending,  or to the best of the
                  Company's knowledge, threatened against the Company, except as
                  disclosed in the Disclosure Documents.  This Agreement and the
                  Disclosure  Documents do not contain any untrue statement of a
                  material  fact  and do not  omit to state  any  material  fact
                  required to be stated  therein or herein or  necessary to make
                  statements  contained  therein or herein not misleading in the
                  light of the circumstances under which they were made.

         6.3      Authorization. All corporate action on the part of the Company
                  by its officers,  directors and shareholders necessary for the
                  authorization,  execution and delivery of this Agreement,  the
                  performance of all  obligations  of the Company  hereunder and
                  the  authorization,  issuance and  delivery of the  Debentures
                  being  sold  hereunder  and  issuance  (and   reservation  for
                  issuance) of the Common Stock  obtainable on conversion of the
                  Debentures  have  been  taken,  and  this  Agreement  and  the
                  Registration  Rights  Agreement  constitute  valid and legally
                  binding obligations of the Company,  enforceable in accordance
                  with their  terms.  The Company has  obtained all consents and
                  approvals  required  for it to execute,  deliver,  and perform
                  this Agreement.  The Company is not in violation or default of
                  any provisions of its Articles of Incorporation or By-laws, as

                  amended and in effect on and as of the date of this Agreement,
                  or of any material  provision of any instrument or contract to
                  which it is a party or by which it is bound or of any material
                  provision  of any  federal or state  judgment,  writ,  decree,
                  order, statute, rule or governmental  regulation applicable to
                  the Company except where such  violation,  default or conflict
                  would  have  no  material  adverse  affect  on  the  Company's
                  business   prospects  or  financial   condition,   or  on  the
                  transaction  contemplated herein. The execution,  delivery and
                  performance  of this  Agreement  and the  consummation  of the
                  transactions  contemplated  hereby will not result in any such
                  violation  or be in  conflict  with  or  constitute,  with  or
                  without  the  passage of time and  giving of notice,  either a
                  default under any such provision, instrument or contract or an
                  event which  results in the  creation  of any lien,  charge or
                  encumbrance upon any assets of the Company.

         6.4      Valid Issuance of  Securities.  The  Debentures,  when issued,
                  sold and delivered in accordance with the terms hereof for the
                  consideration  expressed  herein,  will be validly  issued and
                  binding obligations of the Company,  enforceable in accordance
                  with their terms, and, based in part upon the  representations
                  of the  Subscriber  in  this  Agreement,  will  be  issued  in
                  compliance  with  all  applicable   U.S.   federal  and  state
                  securities  laws. The Common Stock issuable upon conversion of
                  the  Debentures,  when issued in accordance  with the terms of
                  the   Debentures,   shall  be  duly  and  validly  issued  and
                  outstanding,  fully paid and nonassessable,  and based in part
                  on the  representations  and  warranties  of Subscriber of the
                  Debentures,  will be issued in compliance  with all applicable
                  U.S.  federal  securities laws and State Acts. The Shares will
                  be issued free of any preemptive  right. The Company currently
                  has at least 4.8 million  shares  reserved for  issuance  upon
                  conversion of the Debentures.

         6.5      Current  Public   Information.   The  Company  represents  and
                  warrants to the  Subscriber  that the Company is a  "reporting
                  issuer" as defined in Rule 902(1) of Regulation S and it has a
                  class of securities registered under Section 12(b) or 12(g) of
                  the Exchange  Act or is required to file  reports  pursuant to
                  Section 13 or 15(d) of the Exchange Act, and has filed all the
                  materials  required  to be filed as  reports  pursuant  to the
                  Exchange Act for a period of at least twelve months  preceding
                  the date hereof (or for such shorter period as the Company was
                  required by law to file such  material),  and all such filings
                  have been made on a timely  basis.  The Company  undertakes to
                  furnish the Subscriber with copies of such  information as may
                  be   reasonably   requested   by  the   Subscriber   prior  to
                  consummation of this Offering.

         6.6      No  Securities  Offered  in U.S.  or to any U.S.  Person.  The
                  Company  represents  that it has not offered the Debentures to
                  the  Subscriber  in the U.S.  or to any  person in the  United
                  States or any U.S.  person (as defined in Regulation S) unless
                  such U.S.  person is a  professional  fiduciary  of a non-U.S.
                  person (as  defined in Section (o) (2) through (o) (4) of Rule
                  902 of Regulation S).

         6.7      No  Directed  Selling  Efforts in Regard to this  Transaction.
                  Neither the Company,  nor to the knowledge of the Company, the
                  Placement  Agent, any other  distributor  participating in the
                  Offering (if any), or any person  acting for the Company,  the
                  Placement  Agent or any such  distributor,  has  conducted any
                  "directed  selling efforts" in the United States,  as the term
                  "directed  selling  efforts"  is  defined  in Rule  902(b)  of
                  Regulation S with respect to the  Offering,  which in general,
                  means any  activity  undertaken  for the  purpose  of, or that
                  could   reasonably   be   expected  to  have  the  effect  of,
                  conditioning  the market in the  United  States for any of the
                  Securities  being offered in reliance upon  Regulation S. Such
                  activity includes,  without limitation, the mailing of printed
                  material  to  investors  residing  in the United  States,  the
                  holding of promotional  seminars in the United States, and the
                  placement of advertisements  with radio or television stations
                  broadcasting  in the United States or in  publications  with a
                  general  circulation in the United States,  that refers to the
                  offering of the Securities.

         6.8      Capitalization Structure of the Company. The capitalization of
                  Company, as of the date of the Closing, after giving effect to
                  the issuances of the  Securities in this  Offering,  is as set
                  forth in Exhibit N.

         6.9      Termination  Date of  Offering.  In no  event  shall  the Last
                  Closing  of a sale  of a  Debenture  in  connection  with  the
                  Offering,  occur later than March 15, 1996,  which date can be
                  extended by up to 10 days upon written approval by the Company
                  and the Placement Agent.

         6.10     Use of Proceeds. As of the date hereof, the Company expects to
                  use the proceeds from this  Offering  (less fees and expenses)
                  for the purposes and in the  approximate  amounts set forth in
                  Exhibit O hereto. These purposes and amounts are estimates and
                  are subject to change.

         6.11     Intellectual  Property.  The Company has a valid unrestricted,
                  enforceable and exclusive  license for the use of all patents,
                  trademarks, trademark registrations,  trade names, copyrights,
                  trade secrets,  know-how,  technology  and other  intellectual
                  property  necessary to the conduct of its business,  except to
                  the  extent  such  rights  have  been  licensed,  assigned  or
                  otherwise  transferred  to others,  as  indicated  on Schedule
                  IP-1. To the best of the Company's  knowledge,  the Company is
                  not  infringing  on the  intellectual  property  rights of any
                  third  party,  nor  is  any  third  party  infringing  on  the
                  Company's   intellectual   property   rights.   There  are  no
                  restrictions in any agreements, licenses, franchises, or other
                  instruments   that  are  necessary  for  the  conduct  of  the
                  Company's business as presently  conducted or as planned to be
                  conducted  in the future that  materially  interfere  with the
                  conduct of such  business..  The Company has granted valid and
                  enforceable licenses to others as listed on Schedule IP-1.

         6.12     Levy Family Loan Repayment.  The outstanding Levy family loans
                  may be repaid out of the proceeds of the Offering according to
                  the following schedule of repayment preconditions and in the
                  following limited monthly amounts:

                                                  Repayment        Maximum
        Repayment Precondition                     Tranche     Monthly Repayment

        1.  GMP Status Achieved                    $250,000        $125,000
        2.  Filing of Injectable Calcitonin IND    $250,000        $125,000
        3.  Filing of Oral Calcitonin IND          $250,000        $125,000
        4.  Contract with a "Strategic Marketing
         Partner" (as defined below)               $500,000        $250,000

                  Repayments shall become permissible as of the beginning of the
                  calendar  month  immediately  following the month in which the
                  specified  precondition  is  satisfied.  During any one month,
                  repayment  may only be made  towards one  eligible  "Repayment
                  Tranche".  If an additional Repayment Tranche becomes eligible
                  during a month an initial  Repayment  Tranche is already being
                  repaid, repayment under the additional Repayment Tranche shall
                  be delayed  until the  calendar  month  immediately  following
                  repayment in full of the initial Repayment Tranche.

                  Strategic Marketing Partner: Strategic Marketing Partner shall
                  mean any person or entity  which has entered into an agreement
                  with the Company which provides (a) that such person or entity
                  will   arrange  for  the   marketing,   manufacturing   and/or
                  distribution  services  for  the  Company's  amidated  peptide
                  products developed and/or manufactured utilizing the Company's
                  proprietary  technology  and (b) that  such  person  or entity
                  will,  at the  Company's  discretion,  (1)  make an  aggregate
                  payment of at least $2,000,000 to the Company in up-front fees
                  and/or scheduled already known fixed payments over the term of
                  the agreement or (2) if the marketing territory covered by the
                  agreement includes one or more of the United States, Japan, or
                  any  European  country,  pay the Company at least a 5% royalty
                  over the term of the agreement.


         6.13     Shareholder  Approval.  The Company covenants to submit to its
                  shareholders at its next annual shareholder meeting a proposal
                  for  ratification  of the issuance of the  Debentures  and the
                  Common Stock  issuable upon  conversion  thereof.  The Company
                  further covenants to use it best efforts to have such proposal
                  approved by the necessary shareholder vote, if and as required
                  by  the  rules  of  the  National  Association  of  Securities
                  Dealers,  Inc.  (the "NASD")  applicable  to the  transaction.
                  Neither the  failure to obtain  stockholder  approval  nor the
                  Company's lack of financial  ability to redeem Debentures will
                  release the Company from its contractual  obligations to issue
                  unrestricted  and  unlegended   shares  of  Common  Stock,  in
                  accordance   with  the  terms  of  the   Debentures  and  this
                  Agreement, upon the conversion of the Debentures.

7.       Covenants of Company

         7.1      Independent  Auditors.  The  Company  shall,  until  at  least
                  February 28,  1999,  maintain as its  independent  auditors an
                  accounting firm authorized to practice before the Commission.

         7.2      Corporate  Existence and Taxes.  The Company  shall,  until at
                  least the  earlier of March 5,  1999,  and the  conversion  or
                  redemption of all the  Debentures  purchased  pursuant to this
                  Agreement  maintain its  corporate  existence in good standing
                  (provided,  however,  that the  foregoing  covenant  shall not
                  prevent the Company from entering into any merger or corporate
                  reorganization  as  long  as  the  surviving  entity  in  such
                  transaction,   if  not  the  Company,  assumes  the  Company's
                  obligations  with respect to the Debentures) and shall pay all
                  its material taxes when due except for taxes which the Company
                  reasonably disputes.

         7.3      Opinion of Counsel.  Subscriber  shall,  upon  purchase of the
                  Debentures,  receive an opinion letter from outside counsel to
                  the Company,  in the form attached hereto as Exhibit P, to the
                  effect that (i) the Company is duly  incorporated  and validly
                  existing  under  the laws the  state of  Delaware;  (ii)  this
                  Agreement,  the Registration Rights Agreement, the Irrevocable
                  Instructions   to  Transfer   Agent,   the   issuance  of  the
                  Debentures,   and  the  issuance  of  the  Common  Stock  upon
                  conversion of the Debentures  have been duly authorized by all
                  required  corporate action, and that all such Shares of Common
                  Stock, upon delivery,  shall be validly issued, fully paid and
                  nonassessable;  (iii) this Agreement,  the Registration Rights
                  Agreement,  and the Irrevocable Instructions to Transfer Agent
                  constitute  valid  and  binding  obligations  of the  Company,
                  enforceable  in  accordance   with  their  terms,   except  as
                  enforceability  of  any  indemnification   provisions  may  be
                  limited by principles of public policy, and subject to laws of
                  general application relating to bankruptcy, insolvency and the
                  relief  of  debtors  and  rules  of  laws  governing  specific
                  performance and other equitable remedies;  (iv) based upon the
                  representations and warranties of the Subscribers contained in
                  the  Regulation  S  Subscription  Agreements  entered  into in
                  connection  with  the  Offering  and the  representations  and
                  warranties of the  Placement  Agent set forth in the Manner of
                  Offering Certificate of the Placement Agent, and assuming that
                  no  Subscriber  is  engaged  in a plan or  scheme to evade the
                  registration  requirements  of the Act,  the  issuance  of the
                  Debentures has been effected in compliance  with Regulation S,
                  and  the  issuance  of  the  Shares  upon  conversion  of  the
                  Debentures  in accordance  with their terms by the  Subscriber
                  (assuming that no commission or other  remuneration is paid or
                  given, directly or indirectly, for soliciting such conversion)
                  will not be subject to the registration provisions of the Act;
                  and  (v)  the  execution,  delivery  and  performance  of this
                  Agreement and the other agreements  entered into in connection
                  herewith,  does not conflict with or result in a breach of the
                  Company's   Articles  of   Incorporation,   By-laws,   or  any
                  agreement,   relating  to  the  issuance  of  securities,  the
                  incurrence of funded  indebtedness or registration  rights, to
                  which the Company is a party or by which its property is bound
                  or any  judgment,  or decree to which it is  subject,  that is
                  identified to such counsel by the Company.

         7.4      Registration  Rights.  The Company will grant  Subscriber  the
                  registration  rights  covering  the Common  Stock  issuable on
                  conversion of the Debentures on the terms of the  Registration
                  Rights Agreement attached hereto as Exhibit Q.

         7.5      Notification  of Final  Closing  Date &  Restricted  Period by
                  Company. Within five (5) business days after the Last Closing,
                  the Company  shall notify the  Subscriber  in writing that the
                  Last Closing has occurred,  the date of the Last Closing,  the
                  date upon which the  Restricted  Period  will  terminate  with
                  respect to the Securities,  the dates that the Subscribers are
                  entitled   to  convert  the   respective   portions  of  their
                  Debentures  and the Fixed  Conversion  Price,  as that term is
                  defined in the Debenture.

         7.6      Payments for Late Conversion or Failure to Reserve  Authorized
                  but Unissued Common.

                  (a)  Payments  for  Late  Conversion.  As  set  forth  in  the
                  Debentures,  the Transfer Agent or the Company (as applicable)
                  shall,  no later  than 6:00 P.M.  (New York City  time) on the
                  third  business  day (the  "Deadline")  after  receipt  by the
                  Company or its Transfer  Agent of a notice of  conversion  and
                  all necessary  documentation  duly executed and in proper form
                  required  for  conversion,  including  receipt by the Transfer
                  Agent  of the  original  Debentures  to be  converted,  all in
                  accordance   with  the  terms  of  the   Debentures  and  this
                  Agreement,  issue a  certificate  for the  number of shares of
                  Common Stock to which the holder  ("Holder") of the Debentures
                  shall be entitled as aforesaid  and  surrender  such  original
                  Common  Stock  certificates  to a common  courier  for  either
                  overnight or (if delivery is outside the United  States) 2-day
                  delivery  to the  Holder at the  address  of the Holder on the
                  books of the Company.  The Company understands that a delay in
                  the issuance and delivery of the Shares of Common Stock beyond
                  the Deadline  could result in economic loss to the Holder.  As
                  compensation  to the Holder for such loss,  the Company agrees
                  to pay late payments to the Holder for late issuance of Shares
                  upon  conversion  in accordance  with the  following  schedule
                  (where  "No.  Business  Days Late" is defined as the number of
                  business days beyond the Deadline):

                                                 Late Payment For Each
                                                 $10,000 Of Debenture Principal
                  No. Business Days Late             Amount Being Converted
                  ----------------------             ----------------------

                           1                              $100
                           2                              $200
                           3                              $300
                           4                              $400
                           5                              $500
                           6                              $600
                           7                              $700
                           8                              $800
                           9                              $900
                           10                             $1,000
                           greater than 10                $1,000 + $200 for each
                                                               Business Day Late
                                                               beyond 10 days

                  In the event  that the  number of shares of Common  Stock that
                  the  Company  reasonably  calculates  to be  due a  particular
                  Subscriber  upon  conversion  is different  from the number of
                  shares claimed by the Subscriber, by virtue of the calculation
                  of the conversion  rate or other  information set forth in its
                  Notice of  Conversion,  the Company  shall direct the Transfer
                  Agent to issue,  in accordance  with the  procedures set forth
                  above and in the  Debentures,  to the Subscriber  certificates
                  for a number of shares  equal to the lesser of the two numbers
                  and, as to the issuability of the remaining disputed number of
                  shares of Common Stock,  shall submit the dispute within three
                  business  days after the  receipt of such  Holder's  Notice of
                  Conversion to the  Company's  usual  outside  accounting  firm
                  ("Accountant")  for  determination  of the number of shares of
                  Common Stock to be issued. In the event of such a dispute, the
                  Company  agrees to instruct its  Accountant,  at the Company's
                  expense, to resolve any such dispute and notify the parties of
                  the result within three  business days after the  Accountant's
                  receipt of notice of such dispute. Within two business days of
                  its receipt of the  Accountant's  results,  the Company  shall
                  direct  the  Transfer   Agent  to  issue  to  the   Subscriber
                  certificates for any additional shares (the "Disputed Shares")
                  to which the Subscriber is entitled. The Disputed Shares shall
                  not be subject to the late payment  provisions of this Section
                  7.6(a).

                  To the extent  that the  failure  of the  Company to issue the
                  Common  Stock  pursuant  to  this  Section  7.6  is due to the
                  unavailability  of  authorized  but unissued  shares of Common
                  Stock,  the  provisions of this Section 7.6(a) shall not apply
                  but instead the provisions of Section 7.6(b) shall apply.

                  The Company shall pay any payments incurred under this Section
                  7.6(a)  in  immediately   available  funds  within  three  (3)
                  business  days  from the date of  issuance  of the  applicable
                  Common Stock.  Nothing  herein shall limit a Holder's right to
                  pursue actual  damages for the Company's  failure to issue and
                  deliver  Common  Stock to the Holder  pursuant to the terms of
                  the Debenture.

                  (b)  Payments for Failure to Reserve  Authorized  but Unissued
                  Common . If,  at any time a Holder  of  Debentures  submits  a
                  Notice  of  Conversion  (as  defined  in the  Debenture),  the
                  Company  does  not have  sufficient  authorized  but  unissued
                  shares  of  Common  Stock  available  to  effect,  in full,  a
                  conversion of the Debentures under Section 4 of the Debenture,
                  subject to the  Company's  right to redeem such  Debentures in
                  accordance with the terms thereof (a "Conversion Default", the
                  date  of  such  default  being   referred  to  herein  as  the
                  "Conversion  Default  Date"),  the Company  shall issue to the
                  Holder all of the shares of Common Stock which are  available,
                  and the Notice of Conversion as to any Debentures requested to
                  be converted but not converted (the "Unconverted  Debentures")
                  shall become null and void.  The Company shall provide  notice
                  of such Conversion Default ("Notice of Conversion Default") to

                  each Holder of outstanding  Debentures,  by facsimile,  within
                  three (3)  business  days of such  default  (with the original
                  delivered by overnight  or two (2) day  courier).  Holders may
                  not submit a Notice of Conversion after receipt of a Notice of
                  Conversion  Default until the date additional shares of Common
                  Stock are authorized by the Company.

                           The   Company   agrees  to  pay  to  all  Holders  of
                  outstanding  Debentures  payments  for  a  Conversion  Default
                  ("Conversion  Default  Payments")  in the  amount of (N/365) x
                  (.24)  x  the  initial   issuance  price  of  the  outstanding
                  Debentures  held by each  Holder  where N = the number of days
                  from  the   Conversion   Default   Date  to  the   date   (the
                  "Authorization Date") that the Company authorizes a sufficient
                  number of shares of Common Stock to effect  conversion  of all
                  remaining   Debentures.   The   Company   shall  send   notice
                  ("Authorization   Notice")  to  each  Holder  of   outstanding
                  Debentures, by facsimile, within three (3) business days after
                  the  Authorization   Date  (with  the  original  delivered  by
                  overnight or two (2) day courier)  that  additional  shares of
                  Common Stock have been authorized,  the Authorization Date and
                  the amount of Holder's accrued  Conversion  Default  Payments.
                  The accrued  Conversion Default shall be paid in cash or shall
                  be convertible  into Common Stock at the  Conversion  Rate (as
                  that  term is  defined  in the  Debenture),  at the  Company's
                  option,  and shall be  payable to each  Holder of  outstanding
                  Debentures by the fifth day of the following calendar month.

                  Nothing  herein shall limit the  Subscriber's  right to pursue
                  actual  damages  for  the  Company's  failure  to  maintain  a
                  sufficient number of authorized shares of Common Stock.

                           7.7 Listing.  The Company  shall  effect,  as soon as
                  practicable following the Closing,  subject to Company's right
                  to redeem such Debentures, the listing of the shares of Common
                  Stock issuable upon the conversion of the Debentures on Nasdaq
                  or another national securities exchange or quotation system.

         8. Events of Defaults.  If any of the following events of default (each
an "Event of Default") shall occur:

                           8.1 Conversion.  The Company fails to issue shares of
                  Common Stock to the Holder upon  exercise by the Holder of the
                  conversion  rights of the Holder in accordance  with the terms
                  of the  Debenture  and this  Agreement  fails to transfer  any
                  certificate  for shares of Common  Stock  issued to the Holder
                  upon  conversion  of the  Debenture  and when  required by the
                  Debenture  or fails to remove  any  restrictive  legend on any
                  certificate or any shares of Common Stock issued to the Holder
                  upon  conversion  of the Debenture as and when required by the
                  Debenture  or  this  Agreement  and  any  such  failure  shall
                  continue uncured for 10 trading days;

                           8.2 Breach of  Covenant.  The  Company  breaches  any
                  material  covenant or other  material term or condition of the
                  Debenture (other than as specifically  provided in Section 8.1
                  hereof),  or this Agreement and the breach of which would have
                  a material  adverse  effect on the Company or the prospects of
                  the Company or a material  adverse effect on the Holder or the
                  rights of the Holder  with  respect to the  Debentures  or the
                  shares  of  Common  Stock  issuable  upon  conversion  of  the
                  Debentures and such breach  continues for a period of ten (10)
                  business days after written notice thereof to the Company from
                  the Holder;

                           8.3 Breach of  Representations  and  Warranties.  Any
                  representation  or warranty  of the Company  made herein or in
                  any  agreement,  statement  or  certificate  given in  writing
                  pursuant  hereto or in connection  herewith  shall be false or
                  misleading in any material respect when made and the breach of
                  which would have a material  adverse  effect on the Company or
                  the prospects of the Company or a material  adverse  effect on
                  the  Holder or the rights of the  Holder  with  respect to the
                  Debentures  or  the  shares  of  Common  Stock  issuable  upon
                  conversion of the Debentures;

                           8.4   Receiver  or   Trustee.   The  Company  or  any
                  subsidiary  of the Company  shall make an  assignment  for the
                  benefit  of  creditors,   or  apply  for  or  consent  to  the
                  appointment  of  a  receiver  or  trustee  for  it  or  for  a
                  substantial  part  of its  property  or  business;  or  such a
                  receiver or trustee shall otherwise be appointed;

                           8.5 Judgments.  Any money  judgment,  writ or similar
                  process  shall be entered or filed  against the Company or any
                  subsidiary  of the  Company  or any of its  property  or other
                  assets for more than  $500,000,  and shall  remain  unvacated,
                  unbonded or  unstayed  for a period of thirty (30) days unless
                  otherwise  consented to by the Holder,  which consent will not
                  be unreasonably withheld; or

                           8.6     Bankruptcy.      Bankruptcy,      insolvency,
                 reorganization  or liquidation  proceedings or other proceeding
                 for relief under any  bankruptcy  law or any law for the relief
                 of debtors shall be instituted by or against the Company or any
                 subsidiary  of the Company and any such  proceeding  instituted
                 against the Company or any  subsidiary is not dismissed  within
                 thirty (30) days.

                  Then upon the occurrences  and during the  continuation of any
Event of Default  specified in Section 8.1,  8.2,  8.3, 8.4, 8.5 or 8.6 upon the
written notice of the Holders of 75% of the outstanding  principal amount of the
Debentures,  the Company shall, and upon the occurrences of any event of default
specified in Section 8.4 or 8.6,  the Company  shall pay to the Holder an amount
equal to (a) the sum of (1) the unpaid  principal amount of the Debentures owned
by such  Holder plus (2)  accrued  and unpaid  interest on the unpaid  principal
amount of the Debentures owned by such Holder to the date of payment; multiplied
by (b) the percentage (the "Default Percentage") set forth below with respect to
the date on which such Event of Default occurs:

Date of Event of Default                                  Default Percentage
- ------------------------                                  ------------------

Date of Last Closing to 18 months                                 130%
following Last Closing

18 months and 1 day to 24 months                                  125%
following Last Closing

24 months and 1 day to 30 months                                  120%
following Last Closing

After 30 months following Last Closing                            115%

                  In  addition,   all  other  amounts  payable  hereunder  shall
immediately become due and payable, all without demand,  presentment, or notice,
all of which hereby are expressly  waived,  together with all costs,  including,
without limitation,  legal fees and expenses,  of collection to which the Holder
is lawfully  entitled,  and the Holder  shall be entitled to exercise  all other
rights and remedies available at law or in equity.

                  If the Company  fails to pay any amounts due  pursuant to this
Article 8 within 5 business days of such amounts being due and payable, then the
Holder  shall  have the right at any time,  so long as the  Company  remains  in
default,  to require the Company,  upon written notice, to immediately issue, in
lieu of such amounts,  the number of shares of Common Stock of the Company equal
to the  amounts  owed by the Company to the  Holder,  divided by the  Conversion
Price then in effect.

9.       Governing Law

         This  Agreement  shall be governed by and construed in accordance  with
the laws of the state of Delaware,  U.S.A.  applicable to agreements made in and
wholly to be performed in that  jurisdiction,  except for matters  arising under
the Act or the Exchange Act which matters shall be construed and  interpreted in
accordance with such laws. Any action brought to enforce,  or otherwise  arising
out of, this Agreement shall be heard and determined only in either a federal or
state court sitting in the County of New Castle in the State of Delaware, U.S.A.

10.      Entire Agreement; Written Amendments Required

         This Agreement, the Debentures,  the Registration Rights Agreement, the
Irrevocable  Instructions to Transfer Agent (except as set forth  therein),  the
Escrow  Agreement and the other documents  delivered  pursuant hereto or thereto
constitute the full and entire  understanding  and agreement between the parties
with regard to the subjects hereof and thereof,  and no party shall be liable or
bound to any other  party in any manner by any  warranties,  representations  or
covenants  except as  specifically  set forth  herein or therein.  Neither  this
Agreement nor any term hereof may be amended,  waived,  discharged or terminated
other than by a written  instrument signed by the party against whom enforcement
of any such amendment, waiver, discharge or termination is sought.

11.      Written Notices, Etc.

         Any  notice,  demand or request  required or  permitted  to be given by
either the Company or the  Subscriber  pursuant  to the terms of this  Agreement
shall be in writing and shall be deemed given when delivered  personally,  or by
facsimile  (with a hard  copy  to  follow  by  either  overnight  or two (2) day
courier),  addressed to the Subscriber at the address and/or facsimile telephone
number set forth at the end of this Agreement and to Unigene Laboratories,  Inc.
at 110 Little Falls Road, Fairfield,  New Jersey 07004 (or such other address as
a party may request by notifying the other in writing).


12.      Execution in Counterparts Permitted

         This Agreement may be executed in any number of  counterparts,  each of
which  shall  be  enforceable   against  the  parties  actually  executing  such
counterparts, and all of which together shall constitute one instrument.

13.       Representations and Warranties Survive the Closing;
          Agreement is Severable

         The Subscriber's and the Company's representations and warranties shall
survive  the  closing  of the  transaction  notwithstanding  any  due  diligence
investigation made by or on behalf of the party seeking to rely thereon.  In the
event that any provision of this Agreement  becomes or is declared by a court of
competent  jurisdiction  to be illegal,  unenforceable  or void,  this Agreement
shall to the extent  permitted by law continue in full force and effect  without
said  provision;  provided  that no such  severability  shall be effective if it
materially changes the economic benefit of this Agreement to any party.

14.      Titles and Subtitles; Gender

         The  titles  and  subtitles   used  in  this  Agreement  are  used  for
         convenience  only  and  are  not  to be  considered  in  construing  or
         interpreting this Agreement.  The use in this Agreement of a masculine,
         feminine or neuter  pronoun  shall be deemed to include a reference  to
         the others.

15.      Exact Registered Name of Security  Holder; Offshore Delivery
         Instructions

                  (a) Subscriber  agrees to provide  Company with the exact name
in which he, she or it wishes the  Securities to be registered by providing that
information on the accompanying signature page of this Agreement.  Additionally,
Subscriber also agrees to provide Company with detailed delivery instructions to
an offshore addressee and will also provide that information on the accompanying
signature page of this Agreement.

                  (b)  Subscriber  agrees to courier to Company  his, her or its
original inked signed Subscription Agreement within 2 days of faxing said signed
Agreement to the Placement Agent.

16.      Limitations on Assignment of this Agreement.

         Neither party to this Agreement may assign this  Agreement  without the
prior written consent of the other (which may be withheld for any reason).  This
provision  does not limit the  Subscriber's  right to  transfer  the  Securities
pursuant to the terms of the Debenture and this Agreement.

17.      Subscription and Wiring Instructions; Irrevocability

         (a) Subscriber shall send a copy of its signed  Subscription  Agreement
by  facsimile  to  Placement  Agent  at  (770)  640-7150,  and  shall  send  its
subscription funds by wire transfer, to the Escrow Agent as follows:

                  First Union National Bank of Georgia
                  Attn:  Rick Schaal
                  Corporate Trust Administration
                  999 Peachtree Street, N.E., Suite 1100
                  Atlanta, Georgia  30309
                  Fax:  404-827-7305

                  ABA Number: 053000219
                  Account Number:  465946
                  Attn:  Claire Moore
                  Ref:  UNIGENE LABORATORIES, INC./Swartz Investments, LLC
                  Ref:  Subscriber's Name
                  A/C 3072232630
                  Contact Nicole Stefanini

         (b) The  Subscriber  hereby  acknowledges  and  agrees,  subject to the
provisions  of any  applicable  laws  providing  for the refund of  subscription
amounts submitted by the Subscriber, that this Agreement is irrevocable and that
the  Subscriber is not entitled to cancel,  terminate or revoke this  Agreement;
provided, however, that if the conditions to Closing are not satisfied or if the
Disclosure Documents are discovered prior to Closing to contain statements which
are materially  inaccurate,  or omit statements of material fact, the Subscriber
may revoke or cancel this Agreement.

         (c) This Agreement  shall be accepted by the Company when the Agreement
is  countersigned  by the  Company  and  delivered  to  the  Escrow  Agent.  The
Subscriber  hereby  confirms  that  the  Company  has  full  right  in its  sole
discretion to accept or reject the  subscription of the Subscriber,  in whole or
in part, provided that, if the Company decides to reject such subscription,  the
Company  must do so  promptly  and in  writing.  In the case of  rejection,  the
Company will promptly return any rejected  payments  (together with any interest
earned on such rejected funds in the escrow  account) and (if rejected in whole)
copies of all executed subscription documents (including without limitation this
Agreement) to Subscriber.  The Company may terminate this Agreement prior to the
Closing  if  this  Agreement  is  discovered  to  contain  statements  that  are
materially inaccurate or to or omit statements of material fact.

18.      Indemnification.

         The Company shall indemnify and hold harmless the Subscriber, Placement
Agent  and each of  their  officers,  directors,  employees,  partners,  control
persons and agents (a "Subscriber  Indemnified  Party") who is or may be a party
to any threatened, pending, or completed action, suit or proceeding of any kind,
against any losses,  damages,  liabilities  and expenses  (including  reasonable
attorneys fees) suffered or incurred by a Subscriber  Indemnified  Party and not
otherwise  reimbursed,  arising  from  or  due  to  any  material  breach  of  a
representation  warranty or covenant of the Company contained in this Agreement.
The  Subscriber  shall  indemnify  and hold harmless the Company and each of its
officers, directors, employees, partners, control persons and agents (a "Company
Indemnified  Party")  who is or may be a party to any  threatened,  pending,  or
completed action, suit or proceeding of any kind, against any losses, damages,
liabilities  and expenses  (including  reasonable  attorneys  fees)  suffered or
incurred by a Company  Indemnified Party and not otherwise  reimbursed,  arising
from or due to any material breach of a representation,  warranty or covenant of
the Subscriber contained in this Agreement.

19. Amount

         The  undersigned   hereby   subscribes  for   _________________________
principal  amount  of  Debentures,  and pays  herewith  funds in the  amount  of
____________________________ U.S. Dollars ($______________U.S.) on the terms and
conditions of this Agreement.

         The undersigned  acknowledges  that this Agreement and the subscription
represented  hereby  shall not be  effective  unless  accepted by the Company as
indicated below and delivered to the Subscriber.

Dated this _____ day of ___________, 1996.


- ------------------------------------          ---------------------------------
         Your Signature                         EXACT NAME IN WHICH YOU WANT
                                               THE SECURITIES TO BE REGISTERED
                                            (Please Print Exact Registered Name)

                                             OFFSHORE DELIVERY INSTRUCTIONS:
- -------------------------------------       -----------------------------------
Name: Please Print
                                              Please type or print address where
                                               your security is to be delivered.

                                                     ATTN:
                                                          ----------------------

- ------------------------------------            --------------------------------
Title/Representative Capacity (if applicable)     Street Address

- ------------------------------------            --------------------------------
Name of Company You Represent (if applicable)     Street Address

- ------------------------------------            --------------------------------
Place of Execution of this Agreement            City, State or Province, Country


                                                   -----------------------------
                                                       Offshore Postal Code


                                                   -----------------------------
                                              Phone Number (For Federal Express)


                                                   -----------------------------
                                                   Facsimile Number (re: Notice)


THIS SUBSCRIPTION IS ACCEPTED BY THE COMPANY ON THE ____ DAY OF __________ 1996.

                                            UNIGENE LABORATORIES, INC.


                                    By:________________________________
                                                      (Signature)
                                    Print Name: _________________________
                                    Title: ______________________________

                                    EXHIBIT E
                         - UNIGENE LABORATORIES, INC. -
            FIDUCIARY, ADMINISTRATOR, EXECUTOR OR TRUSTEE CERTIFICATE

                  The signatory to this Agreement hereby represents and warrants
                  that he, she or it is a  professional  fiduciary of Subscriber
                  (as described in Section  (o)(2) through (o)(4) of Rule 902 of
                  Regulation  S),  acting  solely in his, her or its capacity as
                  such, and that:

                  (i)  the  Subscriber  is  not a U.S.  person  (as  defined  in
                  Regulation S); and

                  (ii)  either (sign either A, B or C, as applicable):

                           A. The  account  for which the  Debentures  are being
                           purchased by Subscriber is a discretionary account or
                           similar account (other than an estate or trust) which
                           the undersigned  manages and holds for the benefit or
                           account  of  Subscriber  and  the  Subscriber  is not
                           located  in the  U.S.  at the  time of  signing  this
                           Agreement;

                                                   ----------------- (signature)
                           OR

                           B. The  account  for which the  Debentures  are being
                           purchased by  Subscriber  is the account of an estate
                           of  which  the   undersigned   acts  as  executor  or
                           administrator,  an executor or  administrator  of the
                           estate  who is  not a  U.S.  person  (as  defined  in
                           Regulation   S)  has   sole  or   shared   investment
                           discretion  with respect to the assets of the estate,
                           the  estate  is  governed  by  foreign  law  and  the
                           Subscriber  is not located in the U.S. at the time of
                           signing this Agreement;

                                                   ----------------- (signature)
                           OR

                           C. The  account  for which the  Debentures  are being
                           purchased by  Subscriber is the account of a trust of
                           which the undersigned acts as trustee, a trustee, who
                           is not a U.S. person (as defined in Regulation S) has
                           sole or shared investment  discretion with respect to
                           the trust assets, no beneficiary of the trust (and no
                           settlor,  if the trust is revocable) is a U.S. person
                           (as defined in  Regulation  S) and the  Subscriber is
                           not located in the U.S.  at the time of signing  this
                           Agreement.

                                                   ----------------- (signature)

                ---------------------  -----------------------------------------
                   Print Your Name     Person or Entity for Whom You are Signing