EXHIBIT 10.22




                                                                   EXHIBIT 10.22


                                 PROMISSORY NOTE


$700,000.00                                                 Dated: June 29, 1995


         FOR VALUE RECEIVED, UNIGENE LABORATORIES, INC., a Delaware
corporation  authorized  to  do  business  in  the  State  of  New  Jersey  (the
"Undersigned")  promises to pay the order of JAY LEVY, WARREN P. LEVY and RONALD
S. LEVY  jointly  (the  "Lender"),  at their  offices at 110 Little  Falls Road,
Fairfield,   New  Jersey,   the  sum  of  SEVEN  HUNDRED   THOUSAND  and  00/100
($700,000.00)  DOLLARS or so much thereof as may be advanced hereunder from time
to time but not in excess of Seven  Hundred  Thousand  and 00/100  ($700,000.00)
Dollars in the  aggregate at any point in time  (hereinafter  referred to as the
"Principal")  in lawful  money of the United  States of America  with  interest,
calculated  on the  basis  of a 360 day  year,  for the  actual  number  of days
involved,  on the unpaid balance from the date of this  Promissory Note ("Note")
at the rate set forth hereafter until paid.
         The  rate  of  interest  on  the  SEVEN  HUNDRED  THOUSAND  and  00/100
($700,000.00)  DOLLARS  shall  be at the  Merrill  Lynch  Margin  Loan  Rate  as
announced from time to time.
annum.
         Payment  of  Principal  shall be made upon  demand but in any event not
later than February 10, 1997.  Interest only will be payable  monthly in arrears
on the first day of each month commencing October 1, 1995.
         1. As security for the payments of monies owing hereon, the undersigned
has  delivered  to  Lender  a  Security  Agreement  (the  "Security  Agreement")
respecting its assets and equipment  located at its leased business  premises at
83 Fulton Street, Boonton, New Jersey (the "Secured Assets").
         2.       The Undersigned agrees with the Lender hereof:          
                  (a) to claim no  deduction  upon  the  assessed  value of such
Secured Assets on account of the monies owing hereon;
                  (b) to pay  all  taxes,  assessments,  or  other  governmental
charges  levied or assessed  against the Secured Assets as the same shall become
due and payable  unless same are being  contested  in good faith in which event,
the same shall, if requested, be paid to Lender;
                  (c) to keep the Secured  Assets insured for the benefit of the
Lender  hereof  against  damage or loss by fire and such  other  hazards  as the
Lender hereof shall specify,  by insurers and in amounts reasonable  approved by
the Lender  hereof,  and to deliver  such policy or policies of insurance to the
Lender hereof; and
                  (d) to  keep  the  Secured  Assets  in  good  repair  and in a
condition satisfactory to the Lender hereof.
                  The  Undersigned  further agrees that,  should default be made
with regard to the above  agreements,  the Lender,  at its option,  may pay such
amount or amounts  and the  amount so paid  shall be added to the  amount  owing
hereunder and shall be due and payable on demand,  with interest at the rate set
forth above.

         3.  This  Note,  at the  option  of the  Lender  hereof,  shall  become
immediately due and payable in full in the event of any of the following:
                  (a) ten (10) days'  default in any payment of interest  due on
this Note;
                  (b)      default in the payment of principal due on this Note;
                  (c) the  Undersigned  shall (i) apply  for or  consent  to the
appointment of a receiver, trustee or liquidator of the Undersigned for all or a
substantial  part of its  properties  or  assets,  (ii)  admit  in  writing  its
inability to pay its debts as they mature,  (iii) make a general  assignment for
the benefit of creditors,  (iv) be  adjudicated a bankrupt or insolvent,  or (v)
file  a  voluntary   petition   in   bankruptcy,   reorganization,   insolvency,
readjustment of debt,  dissolution or liquidation  law or statute,  or an answer
admitting  the  material  allegations  of a  petition  filed  against  it in any
proceeding  under any such law or if  corporation  action  shall be taken by the
Undersigned for the purpose of effecting any of the foregoing; or
                  (d) an order, judgment or decree shall be entered, without the
application,  approval or consent of the  Undersigned  by any Court of competent
jurisdiction,  approving or seeking  reorganization of the Undersigned or of all
of a  substantial  part of the  properties  or  assets  of the  Undersigned,  or
appointing a receiver,  trustee or liquidator of the Undersigned and such order,
judgment  or decree  shall  continue  unstayed  and in effect  for any period of
forty-five (45) days or more;
                  (e)  failure of the  Undersigned  to comply with the terms and
conditions  of the  Security  Agreement  of  even  date  herewith  given  by the
Undersigned  as  Borrower  to the  Lender as  Secured  Party,  or failure by the
Undersigned  to comply with the terms and conditions of the Loan Agreement or of
any document collateral to this transaction;

                  (f) any default by the Undersigned in any payment of principal
or interest due on any other note or obligation of the Undersigned to Lender; or
                  (g) a  default  is  made  in the  repayment  of  any  mortgage
indebtedness with regard to the premises which the undersigned owns and in which
the Secured Assets are located.
         4.  Any  notice  provisions  contained  in the  Loan  Agreement  or the
Security Agreement shall also apply hereunder.
         5. Presentment, dishonor and notice of dishonor are hereby waived.
         6. Upon nonpayment of this Note at its stated or accelerated  maturity,
the Lender  may,  in  addition  to such other and  further  rights and  remedies
provided by law, or by the Security Agreement referred to above:
                  (a)  collect  interest  from the date of such  maturity on the
principal balance owing hereon at the interest rate(s) set forth herein;
                  (b) hold as security for the payment hereof any other property
heretofore or hereafter  delivered by the Undersigned into the custody,  control
or possession of the Lender for any reason or purpose whatsoever.
         7. If the  Lender  of the Note has not  received  the  full  amount  of
payment of interest due by the end of the ten (10)  calendar days after the date
it is due and payable, a late charge of five (5%) percent of the overdue payment
shall be immediately  due and payable,  which charge shall be for the purpose of
defraying  expenses incident to handling such delinquent  payments.  This charge
shall be in addition  to, and not in lieu of, any other  remedy  Lender may have
and is in addition to Lender's right to collect  reasonable  fees and charges of
any agents or attorneys  which Lender employs in connection with any non-payment
or other event of default.  Acceptance by the Lender of payment of a late charge
shall in no way be  considered  to be an  election  of remedies or waiver by the
Lender of rights at law or under this Note, or the Security Agreement. Such late
charges if not previously paid shall become part of the  indebtedness  evidenced
hereby,  and shall,  at the option of the  Lender,  be added t o any  succeeding
monthly payment due under this Note.  Failure to pay such late charges with such
succeeding  monthly  payment shall  constitute an event of default and such late
charges shall bear  interest at the default rate as hereafter  provided from the
date due.

         8.  Upon the  occurrence  of an event of  default  (including,  without
limitation,  the failure of Borrower to pay any sum herein  specified when due),
the unpaid  principal  sum  evidenced by this Note together with all accrued and
unpaid interest thereon, and all other sums evidenced and/or secured by the Note
and the Security  Agreement,  Loan Agreement and other loan  documents  given in
connection  herewith  shall bear interest at a rate per annum referred to as the
Default  Rate,  which  shall be equal to a lesser  of: (x) the  highest  rate of
interest  permitted to be contracted for under the laws of the State, or (y) the
interest rate first set forth plus five (5%) percent per annum. The Default Rate
shall be in lieu of any  other  interest  rate  otherwise  applicable  and shall
commence,  without notice,  immediately upon and from the occurrence of any such
event of default  effective  as of the due date of the  payment  in default  and
shall  continue  until all  defaults are cured and all sums then due and payable
under the Note and other loan documents are paid in full.
         9. Borrower shall have the right to prepay this Note in full or in part
at any time.
         10.  If this  Note is  referred  to an  attorney  for  collection,  the
Undersigned agrees that reasonable attorney's fees shall be added to such amount
and shall be payable thereon.
         11.  This  Note is  binding  on the  Undersigned,  its  successors  and
assigns.
         12. If there are any inconsistencies  between the Note and the Security
Agreement, the terms of the Security Agreement shall prevail.

         IN WITNESS WHEREOF,  the Undersigned has executed this Note on the date
first above written.

Attest:                                               Unigene Laboratories, Inc.


________________________________                     By ________________________

Ronald S. Levy, Secretary                              Warren P. Levy, President