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December 4, 2001

                                                            FILE NO. 025202-0011

Neurocrine Biosciences, Inc.
10555 Science Center Drive
San Diego, California 92121

Re:  Registration  Statement on Form S-3;  287,500  Shares of Common Stock,  Par
     Value $.001 Per Share

Ladies and Gentlemen:

     In connection  with the  registration  by Neurocrine  Biosciences,  Inc., a
Delaware  corporation (the "Company"),  of 287,500  additional  shares of common
stock of the  Company,  par  value  $.001 per share  (the  "Shares"),  under the
Securities  Act of 1933,  as amended (the "Act"),  pursuant to the  registration
statement on Form S-3 under the  Securities Act of 1933, as amended (the "Act"),
filed with the Securities and Exchange Commission  (the"Commission") on November
13, 2001 (File No.  333-73216)  and  declared  effective  by the  Commission  on
November 20, 2001 (the "Registration Statement"), you have requested our opinion
with respect to the matters set forth below.

     In our capacity as your counsel in connection  with such  registration,  we
are familiar with the proceedings  taken and proposed to be taken by the Company
in connection with the  authorization,  issuance and sale of the Shares, and for
the  purposes of this  opinion,  have assumed  such  proceedings  will be timely
completed in the manner presently proposed. In addition, we have made such legal
and factual examinations and inquiries, including an examination of originals or
copies certified or otherwise  identified to our satisfaction of such documents,
corporate  records and  instruments,  as we have deemed necessary or appropriate
for purposes of this opinion.

     In our examination,  we have assumed the genuineness of all signatures, the
authenticity of all documents  submitted to us as originals,  and the conformity
to authentic original documents of all documents submitted to us as copies.

     We are opining herein as to the effect on the subject  transaction  only of
the General  Corporation Law of the State of Delaware,  including  statutory and
reported  decisional law  thereunder,  and we express no opinion with respect to
the  applicability  thereto,  or the  effect  thereon,  of the laws of any other
jurisdiction  or, in the case of Delaware,  any other laws, or as to any matters
of municipal law or the laws of any local agencies within any state.

     Subject to the  foregoing,  it is our  opinion  that as of the date of this
opinion, the Shares have been duly authorized, validly issued and are fully paid
and nonassessable.

     We consent to your  filing this  opinion as an exhibit to the  Registration
Statement and to the reference to our firm  contained  under the heading  "Legal
Matters."

                                                          Very truly yours,

                                                          /s/ LATHAM & WATKINS