Exhibit 2.1

                      AGREEMENT AND PLAN OF REORGANIZATION

                                  BY AND AMONG

                          NEUROCRINE BIOSCIENCES, INC.,

                              NBI ACQUISITION CORP.

                                       AND

                           NORTHWEST NEUROLOGIC, INC.

                             Dated as of May 1, 1998


TABLE OF CONTENTS                                                                                                    Page

                                                                                                                  
ARTICLE I  THE MERGER.................................................................................................1
         1.1      The Merger..........................................................................................1
         1.2      Effective Time......................................................................................2
         1.3      Effect of the Merger................................................................................2
         1.4      Articles of Incorporation; Bylaws...................................................................2
         1.5      Directors and Officers..............................................................................2
         1.6      Maximum Shares to Be Issued; Effect on Capital Stock................................................3
         1.7      Dissenting Shares...................................................................................5
         1.8      Surrender of Certificates...........................................................................6
         1.9      Forfeiture and Repurchase of Parent Common Stock....................................................8
         1.10     Lockup Period and Restrictions on Future Transfers..................................................9
         1.11     No Further Ownership Rights in Company Capital Stock................................................9
         1.12     Lost, Stolen or Destroyed Certificates.............................................................10
         1.13     Tax Consequences...................................................................................10
         1.14     Taking of Necessary Action; Further Action.........................................................10
         1.15     Restrictive Legends and Stop-Transfer Orders.......................................................10

ARTICLE II  REPRESENTATIONS AND WARRANTIES OF THE COMPANY ...........................................................11
         2.1      Organization of the Company........................................................................11
         2.2      Company Capital Structure..........................................................................12
         2.3      Subsidiaries.......................................................................................12
         2.4      Authority..........................................................................................13
         2.5      Company Financial Statements.......................................................................13
         2.6      No Undisclosed Liabilities.........................................................................14
         2.7      No Changes.........................................................................................14
         2.8      Tax and Other Returns and Reports..................................................................15
         2.9      Restrictions on Business Activities................................................................17
         2.10     Title to Properties; Absence of Liens and Encumbrances.............................................17
         2.11     Intellectual Property..............................................................................18
         2.12     Agreements, Contracts and Commitments..............................................................19
         2.13     Interested Party Transactions......................................................................21
         2.14     Compliance with Laws...............................................................................21
         2.15     Litigation.........................................................................................21
         2.16     Insurance..........................................................................................21
         2.17     Minute Books.......................................................................................22
         2.18     Environmental Matters..............................................................................22
         2.19     Brokers' and Finders' Fees; Third Party Expenses...................................................23
         2.20     Employee Matters and Benefit Plans.................................................................23
         2.21     Tax Treatment......................................................................................26
         2.22     No Existing Discussions............................................................................26
         2.23     Vote Required......................................................................................26
         2.24     Representations Complete...........................................................................27

ARTICLE III  REPRESENTATIONS AND WARRANTIES OF PARENT AND MERGER SUB.................................................27
         3.1      Organization, Standing and Power...................................................................27
         3.2      Authority..........................................................................................27
         3.3      Capital Structure..................................................................................27
         3.4      SEC Documents; Parent Financial Statements.........................................................28
         3.5      Litigation.........................................................................................28

ARTICLE IV  CONDUCT PRIOR TO THE EFFECTIVE TIME......................................................................28
         4.1      Conduct of Business of the Company.................................................................28
         4.2      No Solicitation....................................................................................31

ARTICLE V  ADDITIONAL AGREEMENTS.....................................................................................32
         5.1      Company Stockholder Approval.......................................................................32
         5.2      Access to Information..............................................................................32
         5.3      Confidentiality....................................................................................32
         5.4      Expenses...........................................................................................33
         5.5      Public Disclosure..................................................................................33
         5.6      Consents...........................................................................................33
         5.7      FIRPTA Compliance..................................................................................33
         5.8      Reasonable Efforts.................................................................................33
         5.9      Notification of Certain Matters....................................................................34
         5.10     Affiliate Agreements...............................................................................34
         5.11     Additional Documents and Further Assurances........................................................34
         5.12     Nasdaq National Market Listing.....................................................................34
         5.13     Company's Financial Statements.....................................................................34
         5.14     Milestone Warrants.................................................................................34
         5.15     Oregon Health Sciences University Laboratory Funding...............................................35
         5.16     Name and Physical Location of the Surviving Corporation............................................36
         5.17     [***]..............................................................................................36
         5.18     Employment and Consulting Arrangements.............................................................36
         5.19     Appointment to Parent Scientific Advisory Board....................................................37
         5.20     [***]..............................................................................................37
         5.21     Registration on Form S-8...........................................................................37

ARTICLE VI  CONDITIONS TO THE MERGER.................................................................................37
         6.1      Conditions to Obligations of Each Party to Effect the Merger.......................................37
         6.2      Additional Conditions to Obligations of the Company................................................38
         6.3      Additional Conditions to the Obligations of Parent and Merger Sub..................................38

ARTICLE VII  SURVIVAL OF REPRESENTATIONS AND WARRANTIES; ESCROW......................................................40
         7.1      Survival of Representations and Warranties.........................................................40
         7.2      Escrow Arrangements................................................................................40

ARTICLE VIII  TERMINATION, AMENDMENT AND WAIVER......................................................................40
         8.1      Termination........................................................................................40
         8.2      Effect of Termination..............................................................................41
         8.3      Termination Fee....................................................................................41
         8.4      Amendment..........................................................................................41
         8.5      Extension; Waiver..................................................................................42

ARTICLE IX  GENERAL PROVISIONS.......................................................................................42
         9.1      Notices............................................................................................42
         9.2      Interpretation.....................................................................................43
         9.3      Counterparts.......................................................................................43
         9.4      Entire Agreement; Assignment.......................................................................43
         9.5      Severability.......................................................................................43
         9.6      Other Remedies.....................................................................................44
         9.7      Governing Law......................................................................................44
         9.8      Rules of Construction..............................................................................44
         9.9      Specific Performance...............................................................................44









                      AGREEMENT AND PLAN OF REORGANIZATION


         This AGREEMENT AND PLAN OF  REORGANIZATION  (this  "Agreement") is made
and  entered  into as of May 1,  1998  among  Neurocrine  Biosciences,  Inc.,  a
Delaware corporation  ("Parent"),  NBI Acquisition Corp., a Delaware corporation
and  a  wholly  owned   subsidiary  of  Parent  ("Merger  Sub"),  and  Northwest
NeuroLogic, an Oregon corporation (the "Company").

                                    RECITALS

         A. The Boards of Directors  of each of the  Company,  Parent and Merger
Sub believe it is in the best  interests  of each  Company and their  respective
stockholders  that Parent  acquire the Company  through the statutory  merger of
Merger Sub with and into the Company (the "Merger") and, in furtherance thereof,
have adopted this Agreement and approved the Merger.

         B. Pursuant to the Merger, among other things, and subject to the terms
and conditions of this Agreement,  (i) all of the issued and outstanding  shares
of capital  stock of the Company  ("Company  Capital  Stock") shall be converted
into the  right to  receive  shares of voting  Common  Stock of Parent  ("Parent
Common Stock") and (ii) all outstanding  options ("Company  Options") to acquire
or receive shares of Company  Capital Stock shall be converted into the right to
receive options ("Parent Options") to acquire Common Stock of Parent.

         C. A portion of the shares of Parent  Common  Stock and Parent  Options
otherwise  issuable by Parent in  connection  with the Merger shall be placed in
escrow by Parent,  the release of which amount shall be contingent  upon certain
events and conditions,  all as set forth in the Escrow Agreement  referred to in
Article VII hereof.

         D.  The  Company,   Parent  and  Merger  Sub  desire  to  make  certain
representations  and  warranties  and other  agreements in  connection  with the
Merger.

         E.  Certain  stockholders  of the  Company  have  executed  Voting  and
Non-Disposition Agreements.

         NOW,  THEREFORE,  in  consideration  of  the  covenants,  promises  and
representations set forth herein, and for other good and valuable consideration,
intending to be legally bound hereby the parties agree as follows:


                                    ARTICLE I

                                   THE MERGER




         I.1 The Merger.  At the Effective  Time (as defined in Section 1.2) and
subject  to and  upon  the  terms  and  conditions  of  this  Agreement  and the
applicable  provisions of the Delaware General  Corporation Law ("Delaware Law")
and the Oregon  Business  Corporation  Act ("Oregon  Law"),  Merger Sub shall be
merged with and into the Company, the separate corporate existence of Merger Sub
shall cease, and the Company shall continue as the surviving  corporation and as
a wholly owned  subsidiary of Parent.  The Company as the surviving  corporation
after  the  Merger  is  hereinafter  sometimes  referred  to as  the  "Surviving
Corporation."  At the election of Parent,  any direct wholly owned subsidiary of
Parent may be  substituted  for Merger Sub as a constituent  corporation  in the
Merger.  In such event,  the  parties  hereto  agree to execute the  appropriate
amendment of this Agreement to reflect such substitution.

         I.2 Effective  Time.  Unless this Agreement  is earlier  terminated  
pursuant to Section  8.1,  the closing of the Merger (the  "Closing")  will take
place as  promptly as  practicable,  but no later than five (5)  business  days,
following  satisfaction  or waiver of the conditions set forth in Article VI, at
the offices of Wilson Sonsini Goodrich & Rosati,  650 Page Mill Road, Palo Alto,
California, unless another place or time is agreed to by Parent and the Company.
The date upon which the  Closing  actually  occurs is herein  referred to as the
"Closing  Date." On the Closing Date,  the parties hereto shall cause the Merger
to be consummated by filing an Agreement of Merger (or like instrument) with the
Secretaries of State of the States of Delaware and Oregon (the  "Certificate  of
Merger"), in accordance with the relevant provisions of applicable law (the time
of  acceptance  by the  Secretary  of State of  Delaware  of such  filing  being
referred to herein as the "Effective Time").

         I.3  Effect  of the  Merger.  At the Effective Time, the effect of the
Merger  shall be as provided in the  applicable  provisions  of Delaware Law and
Oregon Law.  Without  limiting  the  generality  of the  foregoing,  and subject
thereto, at the Effective Time, all the property, rights, privileges, powers and
franchises   of  the  Company  and  Merger  Sub  shall  vest  in  the  Surviving
Corporation, and all debts, liabilities and duties of the Company and Merger Sub
shall become the debts, liabilities and duties of the Surviving Corporation.

         I.4      Articles of Incorporation; Bylaws

                  (a)  Unless  otherwise  determined  by  Parent  prior  to  the
Effective  Time, at the Effective  Time,  the Articles of  Incorporation  of the
Company  shall be the Articles of  Incorporation  of the  Surviving  Corporation
until thereafter amended as provided by law and such Articles of Incorporation.

                  (b) Unless otherwise  determined by Parent,  the Bylaws of the
Company,  as in effect  immediately  prior to the Effective  Time,  shall be the
Bylaws of the Surviving Corporation until thereafter amended.

         I.5 Directors and OfficersI.5  Directors and OfficersI.5  Directors and
Officers.  The director(s) of Merger Sub immediately prior to the Effective Time
shall be the initial  director(s)  of the  Surviving  Corporation,  each to hold
office in  accordance  with the  Articles  of  Incorporation  and  Bylaws of the
Surviving  Corporation.  The  officers  of Merger Sub  immediately  prior to the
Effective Time shall be the initial officers of the Surviving Corporation,  each
to hold office in accordance with the Bylaws of the Surviving Corporation.






         I.6 Maximum Shares to Be Issued; Effect on CapitalI.6 Maximum Shares to
Be Issued;  Effect on Capital  StockI.6  Maximum Shares to Be Issued;  Effect on
Capital Stock.  The maximum number of shares of Parent Common Stock to be issued
(including  Parent Common Stock to be reserved for issuance upon exercise of any
of the Company  Options to be assumed by Parent) in exchange for the acquisition
by Parent of all outstanding  Company Capital Stock and Company Options shall be
the Aggregate  Share Number (as defined in Section  1.6(g)(iii)).  No adjustment
shall be made in the  number  of shares of  Parent  Common  Stock  issued in the
Merger as a result of any cash  proceeds  received by the Company  from the date
hereof to the Effective  Time  pursuant to the exercise of options,  warrants or
other  rights  to  acquire  Company  Capital  Stock.  Subject  to the  terms and
conditions of this Agreement,  as of the Effective Time, by virtue of the Merger
and without  any action on the part of Merger Sub,  the Company or the holder of
any shares of the Company Capital Stock, the following shall occur:

                  (a) Conversion of Company Capital Stock. Each share of Company
Capital Stock issued and  outstanding  immediately  prior to the Effective  Time
(other  than any  shares of Company  Stock to be  canceled  pursuant  to Section
1.6(b) and any  Dissenting  Shares as  defined  and to the  extent  provided  in
Section 1.7(a)) will be canceled and extinguished and be converted automatically
into the right to  receive  (subject  to Section  1.8 with  regard to the Escrow
Amount) that number of shares of Parent Common Stock equal to the Exchange Ratio
(as defined in Section  1.6(g)(v)  below),  upon  surrender  of the  certificate
representing  such share of Company  Capital  Stock in the  manner  provided  in
Section 1.8.

                  (b) Cancellation of Parent-Owned and Company-Owned Stock. Each
share of Company Capital Stock owned by Merger Sub,  Parent,  the Company or any
direct or indirect wholly owned subsidiary of Parent or the Company  immediately
prior to the  Effective  Time shall be  canceled  and  extinguished  without any
conversion thereof.

                  (c) Stock  Options.  At the  Effective  Time,  all  options to
purchase Company Capital Stock then  outstanding  under the Company's 1997 Stock
Incentive  Plan (the "Option  Plan") or otherwise  shall be assumed by Parent in
accordance with provisions described below.






                           (i)      At the Effective Time, each outstanding 
Company  Option under the Option Plan or otherwise,  whether vested or unvested,
shall be, in connection with the Merger,  assumed by Parent. Each Company Option
so assumed by Parent under this Agreement shall continue to have, and be subject
to,  the same  terms and  conditions  set  forth in the  Option  Plan  and/or as
provided in the  respective  option  agreements  governing  such Company  Option
immediately  prior to the Effective  Time,  except that: (A) such Company Option
shall be  exercisable  for that number of whole  shares of Parent  Common  Stock
equal to the product of the number of shares of Company  Capital Stock that were
issuable upon exercise of such Company Option immediately prior to the Effective
Time  multiplied  by the  Exchange  Ratio,  rounded down (in the case of Company
Options  granted under the Option Plan) to the nearest whole number of shares of
Parent Common Stock  (subject to Section 1.8 with regard to the Escrow  Amount),
(B) the per share  exercise price for the shares of Parent Common Stock issuable
upon  exercise of such  assumed  Company  Option  shall be equal to the quotient
determined by dividing the exercise price per share of Company  Capital Stock at
which such Company  Option was  exercisable  immediately  prior to the Effective
Time by the  Exchange  Ratio,  rounded up to the nearest  whole  cent,  (C) with
regard to Company  Options held by persons  listed on Schedule  1.9(a)  attached
hereto,  such Company  Option shall be subject to forfeiture in accordance  with
the vesting  schedules  set forth in Section 1.9  hereof,  and (D) such  Company
Option shall be exercisable  for a term equal to the lesser of (i) the remaining
term of the Company Option and (ii) five (5) years from the Effective Time.

                           (ii) It is the  intention  of the  parties  that  the
Company  Options  assumed by Parent  qualify  following  the  Effective  Time as
incentive  stock options as defined in Section 422 of the Code to the extent the
Company Options  qualified as incentive stock options  immediately  prior to the
Effective Time.
                  (d) Capital Stock of Merger Sub. Each share of Common Stock of
Merger Sub issued and outstanding  immediately prior to the Effective Time shall
be  converted  into  and  exchanged  for one  validly  issued,  fully  paid  and
nonassessable  share of Common  Stock of the  Surviving  Corporation.  After the
Effective Time, each stock certificate of Merger Sub evidencing ownership of any
such shares  shall  evidence  ownership  of such shares of capital  stock of the
Surviving Corporation.

                  (e) Adjustments to Exchange Ratio. The Exchange Ratio shall be
adjusted to reflect fully the effect of any stock split,  reverse  split,  stock
dividend (including any dividend or distribution of securities  convertible into
Parent Common Stock or Company Capital Stock), reorganization,  recapitalization
or other like  change with  respect to Parent  Common  Stock or Company  Capital
Stock occurring after the date hereof and prior to the Effective Time.

                  (f) Fractional Shares. No fraction of a share of Parent Common
Stock  will be issued,  but in lieu  thereof,  each  holder of shares of Company
Capital Stock who would otherwise be entitled to a fraction of a share of Parent
Common Stock (after  aggregating all fractional shares of Parent Common Stock to
be received by such  holder)  shall be entitled to receive from Parent an amount
of cash  (rounded  to the  nearest  whole cent) equal to the product of (i) such
fraction,  multiplied  by (ii)  $8.43333  (calculated  as set  forth in  Section
1.6(g)(vi).

                  (g)      Definitions.

                           (i)      Aggregate Common Number.  The "Aggregate 
Common Number" shall mean 591,250 (or the aggregate  number of shares of Company
Capital Stock outstanding immediately prior to the Effective Time).

                           (ii)     Aggregate Option Number.  The "Aggregate 
Option Number" shall mean 158,750 (or the aggregate  number of shares of Company
Capital Stock  issuable upon the exercise of all  outstanding  Company  Options,
warrants and other rights to acquire shares of Company Capital Stock immediately
prior to the Effective Time).





                           (iii)    Aggregate Share Number.  The "Aggregate 
Share Number" shall be 498,022  shares of Common Stock of Parent (which is equal
to $4,200,000 divided by the Market Price), as appropriately adjusted to reflect
the effect of any stock split, stock dividend, reorganization,  recapitalization
or the like with  respect to the Parent  Common Stock  occurring  after the date
hereof and prior to the Effective Time (a "Recapitalization of the Parent Common
Stock").

                           (iv)     Escrow Amount.  The "Escrow Amount" shall be
[***] shares of Parent  Common Stock (which is equal to the product  obtained by
multiplying (x) the sum of the Aggregate  Common Number and the Aggregate Option
Number by (y) the  Exchange  Ratio by (z)  [***].  The  Escrow  Amount  shall be
composed of [***] Vested  Securities  and [***].  Unvested  Securities as of the
Effective Time, as set forth on Schedule 1.6 attached hereto.

                           (v)      Exchange Ratio.  The "Exchange Ratio" shall 
be  0.66403  (which  is equal  to the  quotient  obtained  by  dividing  (x) the
Aggregate  Share Number by (y) the sum of (A) the  Aggregate  Common Number plus
(B) the Aggregate Option Number).

                           (vi)     Market Price.  The Market Price of the 
Parent  Common Stock shall mean $8.43333 per share of Parent Common Stock (which
is equal to the average  closing  price of a share of Parent  Common  Stock,  as
reported  on the Nasdaq  National  Market,  over the  fifteen  (15)  consecutive
trading days ending on the date  preceding the date of public  disclosure of the
Letter  Agreement  between Parent and the Company dated February 27, 1998, which
disclosure date was March 3, 1998).

                           (vii)    Vested Securities.  "Vested Securities"
means shares of Parent Common Stock,  Parent Options or Milestone Warrants which
are vested  pursuant to the vesting  schedule set forth in Section 1.9 as of the
relevant time.

                           (viii)   Unvested Securities.   "Unvested Securities"
means shares of Parent Common Stock,  Parent Options or Milestone Warrants which
are unvested pursuant to the vesting schedule set forth in Section 1.9 as of the
relevant time.

         I.7      Dissenting Shares

                  (a)  Notwithstanding  any  provision of this  Agreement to the
contrary,  any shares of Company Capital Stock held by a holder who has demanded
and perfected appraisal or dissenters' rights for such shares in accordance with
Oregon Law and who, as of the Effective Time, has not  effectively  withdrawn or
lost such appraisal or  dissenters'  rights  ("Dissenting  Shares") shall not be
converted  into or represent a right to receive  Parent Common Stock pursuant to
Section 1.6, but the holder thereof shall only be entitled to such rights as are
granted by applicable law.






                  (b)  Notwithstanding  the provisions of subsection (a), if any
holder of shares of Company  Capital Stock who demands  appraisal of such shares
under Oregon Law shall effectively  withdraw or lose (through failure to perfect
or  otherwise)  the right to  appraisal,  then, as of the later of the Effective
Time and the occurrence of such event, such holder's shares shall  automatically
be converted  into and represent  only the right to receive  Parent Common Stock
and cash in lieu of  fractional  shares as  provided  in  Section  1.6,  without
interest thereon, upon surrender of the certificate representing such shares.

                  (c) The  Company  shall give  Parent (i) prompt  notice of any
written   demands  for  appraisal  of  any  shares  of  Company  Capital  Stock,
withdrawals of such demands, and any other instruments served pursuant to Oregon
Law and received by the Company and (ii) the  opportunity  to participate in all
negotiations  and proceedings with respect to demands for appraisal under Oregon
Law. The Company  shall not,  except with the prior  written  consent of Parent,
voluntarily  make any  payment  with  respect to any demands  for  appraisal  of
capital stock of the Company or offer to settle or settle any such demands.

         I.8      Surrender of Certificates

                  (a)      Exchange Agent.  American Stock Transfer & Trust
Company shall act as exchange agent (the "Exchange Agent") in the Merger.

                  (b)  Parent  to  Provide  Common  Stock.  Promptly  after  the
Effective  Time,  Parent shall make available to the Exchange Agent for exchange
in  accordance  with  this  Article  I and as set  forth on  Schedule  1.6,  the
aggregate  number of shares of Parent  Common  Stock  issuable in  exchange  for
outstanding  shares of Company Capital Stock or upon exercise of Parent Options;
provided,  however,  that on behalf of the holders of Company  Capital Stock and
Company Options,  Parent shall deposit into an escrow account a number of shares
of Parent Common Stock equal to the Escrow Amount out of the aggregate number of
shares of Parent Common Stock otherwise issuable pursuant to sections 1.6(a) and
1.6(c),  provided,  further,  that shares of Parent  Common Stock  issuable upon
exercise of the Parent  Options  shall not be  deposited  in the escrow  account
until  exercise of the relevant  Parent  Option.  Parent shall  deposit into the
escrow account  shares of Parent Common Stock issued  pursuant to Section 1.6(a)
promptly  after the  Effective  Time and shares of Parent  Common  Stock  issued
pursuant to the exercise of Parent Options promptly after exercise thereof.  The
portion of the Escrow  Amount  contributed  on behalf of each  holder of Company
Capital Stock and Company Options shall be in proportion to the aggregate number
of shares of Parent  Common  Stock and Parent  Options  which such holder  would
otherwise be entitled to receive under  sections  1.6(a) and 1.6(c) by virtue of
ownership of outstanding shares of Company Capital Stock and Company Options.






                  (c) Exchange  Procedures.  Promptly after the Effective  Time,
the Surviving Corporation shall cause to be mailed to each holder of record of a
certificate or certificates (the "Certificates")  which immediately prior to the
Effective Time represented outstanding shares of Company Capital Stock and which
shares were  converted  into the right to receive  shares of Parent Common Stock
pursuant to Section 1.6, (i) a letter of  transmittal  (which shall specify that
delivery shall be effected, and risk of loss and title to the Certificates shall
pass, only upon delivery of the  Certificates to the Exchange Agent and shall be
in such form and have such other  provisions as Parent may  reasonably  specify)
and (ii)  instructions for use in effecting the surrender of the Certificates in
exchange for  certificates  representing  shares of Parent  Common  Stock.  Upon
surrender of a Certificate  for  cancellation  to the Exchange  Agent or to such
other agent or agents as may be appointed by Parent,  together  with such letter
of  transmittal,  duly  completed and validly  executed in  accordance  with the
instructions  thereto,  the  holder of such  Certificate  shall be  entitled  to
receive in  exchange  therefor a  certificate  representing  the number of whole
shares of Parent Common Stock (less the number of shares of Parent Common Stock,
if any, (a) to be deposited in the Escrow Fund on such holder's  behalf pursuant
to the Escrow  Agreement  referred to in Article VII hereof,  and (b) subject to
transfer  restrictions  in connection  with the Company's  right to repurchase),
plus cash in lieu of fractional  shares in accordance with Section 1.6, to which
such  holder is  entitled  pursuant  to  Section  1.6,  and the  Certificate  so
surrendered  shall  forthwith  be  canceled.  As soon as  practicable  after the
Effective  Time,  and subject to and in  accordance  with the  provisions of the
Escrow  Agreement  referred to in Article VII hereof,  Parent  shall cause to be
distributed to the Escrow Agent (as defined in the Escrow Agreement  referred to
in Article VII) a certificate or certificates representing that number of shares
of Parent  Common Stock and Parent  Options  equal to the Escrow  Amount,  which
certificate  shall be registered in the names of the  stockholders  to whom such
shares would otherwise be issued. Such shares shall be beneficially owned by the
holders on whose behalf such shares were  deposited in the Escrow Fund and shall
be available to compensate  Parent as provided in the Escrow Agreement  referred
to in Article VII. Until so  surrendered,  each  outstanding  Certificate  that,
prior to the Effective Time, represented shares of Company Capital Stock will be
deemed from and after the Effective Time, for all corporate purposes, other than
the payment of dividends, to evidence the ownership of the number of full shares
of Parent  Common  Stock into which such shares of Company  Capital  Stock shall
have been so converted and the right to receive an amount in cash in lieu of the
issuance of any fractional shares in accordance with Section 1.6.

                  (d)  Distributions  With  Respect to  Unexchanged  Shares.  No
dividends or other distributions with respect to Parent Common Stock declared or
made after the Effective  Time and with a record date after the  Effective  Time
will be paid to the holder of any unsurrendered  Certificate with respect to the
shares of Parent Common Stock represented  thereby until the holder of record of
such Certificate  shall surrender such  Certificate.  Subject to applicable law,
following  surrender of any such Certificate,  there shall be paid to the record
holder of the  certificates  representing  whole  shares of Parent  Common Stock
issued in exchange  therefor,  without interest,  at the time of such surrender,
the amount of  dividends  or other  distributions  with a record  date after the
Effective Time  theretofore  payable with respect to such whole shares of Parent
Common Stock.






                  (e) Transfers of Ownership.  If any  certificate for shares of
Parent  Common  Stock is to be  issued  in a name  other  than that in which the
Certificate  surrendered  in  exchange  therefor  is  registered,  it  will be a
condition of the issuance  thereof that the  Certificate so surrendered  will be
properly  endorsed and otherwise in proper form for transfer and that the person
requesting such exchange will have paid to Parent or any agent  designated by it
any transfer or other taxes  required by reason of the issuance of a certificate
for shares of Parent Common Stock in any name other than that of the  registered
holder of the  Certificate  surrendered,  or established to the  satisfaction of
Parent  or any  agent  designated  by it that  such tax has been  paid or is not
payable.

                  (f) No Liability.  Notwithstanding anything to the contrary in
this Section 1.8, none of the Exchange Agent,  the Surviving  Corporation or any
party  hereto  shall be liable to a holder of shares of Parent  Common  Stock or
Company Capital Stock for any amount properly paid to a public official pursuant
to any applicable abandoned property, escheat or similar law.

         I.9 Forfeiture and Repurchase of Parent Common StockI.9  Forfeiture and
Repurchase of Parent Common StockI.9  Forfeiture and Repurchase of Parent Common
Stock.

                  (a) Vesting Schedule. The shares of Parent Common Stock issued
pursuant to Section  1.6(a)  and/or  issuable  upon  exercise  of the  Milestone
Warrants shall be subject to the right of Parent to  repurchase,  and the Parent
Options  held by those  employees  and  consultants  of the  Company  listed  on
Schedule  1.9(a)  attached  hereto  shall be subject to the risk of  forfeiture,
according to the  following  schedule:  [***] of such shares and Parent  Options
shall  vest at the  Effective  Time;  the  remainder  of such  shares and Parent
Options shall be subject to forfeiture or repurchase,  as applicable,  by Parent
as set forth below,  with such risk of forfeiture or repurchase right lapsing as
to an additional  [***] of each such person's  shares and Parent Options on each
anniversary of the Effective Time, provided that:

                           (i)      Dr. Roger Cone and Dr. Susan Amara.  With
respect to Dr.  Roger Cone and Dr.  Susan  Amara,  all of such  person's  Parent
Common Stock issued  pursuant to Section 1.6(a) above or shares of Parent Common
Stock  issued upon  exercise of Milestone  Warrants not vested  pursuant to this
section as of the date of  termination  shall be subject to repurchase by Parent
at a price per share equal to: (x) the quotient  obtained by dividing [***] paid
by such person for the [***] by the Exchange Ratio, in the case of Parent Common
Stock obtained pursuant to [***], or (y) the [***] by such person in the case of
[***],  in the event of: (A) the holder's  voluntary  termination  of employment
with or services to Parent,  or (B) the involuntary  termination of the holder's
employment  with or services  to Parent for Cause (as  defined  below and not as
defined in their Consulting Agreements). Parent Options owned by Dr. Susan Amara
after the Effective  Time not vested  pursuant to this Section as of the date of
termination shall be subject to forfeiture and shall not be exercisable in event
of: (i) Dr.  Amara's  voluntary  termination  of employment  with or services to
Parent, or (ii) the involuntary  termination of the Dr. Amara's  employment with
or  services  to Parent  for Cause (as  defined  below and not as defined in her
Consulting  Agreement).  In the event of the holder's  termination  by reason of
[***],  the  Unvested  Securities  shall  continue to vest and not be subject to
repurchase  on the  schedule  specified  in Section  1.9(a).  With regard to Dr.
Amara, the vesting schedule set forth in Section 1.9(a) above shall be deemed to
apply first to shares of Parent Common Stock and second to Parent Options,  such
that the  Vested  Securities  held by Dr.  Amara on the  relevant  date shall be
composed of the maximum possible number of shares of Parent Common Stock and the
minimum  possible  number of shares of Parent  Common  Stock  subject  to Parent
Options.





                           (ii)  Other   Current   Employees/Consultants.   With
respect to each other  employee and consultant of the Company listed on Schedule
1.9(a),  all of such person's Parent Common Stock issued upon exercise Milestone
Warrants not vested pursuant to this section as of the date of termination shall
be subject to  repurchase  by Parent at a price per share equal to the  purchase
price paid by such person upon exercise of such Milestone Warrants, in the event
of: (A) the holder's voluntary termination of employment with or services to the
Surviving  Corporation,  or (B)  the  involuntary  termination  of the  holder's
employment  with or services to the Surviving  Corporation for Cause (but not in
the event that he or she is required by Parent to relocate outside the Portland,
Oregon area).  In addition,  for each such person,  all of such person's  Parent
Options,  to the extent not vested  pursuant  to this  Section as of the date of
termination,  shall be subject to forfeiture and shall not be exercisable in the
event of: (i) the holder's voluntary  termination of employment with or services
to the  Surviving  Corporation,  or  (ii)  the  involuntary  termination  of the
holder's employment with or services to Surviving Corporation for Cause (but not
in the  event  that he or she is  required  by Parent to  relocate  outside  the
Portland,  Oregon area).  In the event of the holder's  termination by reason of
death or permanent disability, the Unvested Securities shall continue to vest on
the schedule specified in Section 1.9(a).

                  (b)  Definition of "Cause".  For purposes of this Section 1.9,
"Cause" shall mean the discharge of the employee or consultant  resulting from a
determination  by the  Board  of  Directors  of  Parent  that  the  employee  or
consultant:  (i) has been  convicted  of any felony or a  misdemeanor  involving
dishonesty,  fraud,  theft or embezzlement,  or has committed any other crime or
offense  involving money or property of the Company;  (ii) has failed or refused
in any material respect, to follow reasonable policies or directives established
by the Board of Directors of Parent; (iii) has inadequately performed the duties
and  responsibilities  of his or her position;  or (iv) has failed or refused to
attend  to  duties  or  obligations  of his or her  position.  With  respect  to
subsections 1.9(b)(ii),  (iii) and (iv), "Cause" shall require that the employee
or consultant  shall be given notice of the defect and shall have failed to cure
the defect within a thirty (30) day period  thereafter,  unless the defect is by
nature  incapable of being cured within a  reasonable  period of time,  in which
case no notice and cure period shall apply.

         I.10 Lockup  Period and  Restrictions  on Future  TransfersI.10  Lockup
Period and Restrictions on Future  TransfersI.10  Lockup Period and Restrictions
on Future  Transfers.  All shares of Parent  Common  Stock issued to the persons
listed on Schedule 1.9(a) shall be subject to a [***] lockup  provision from the
Effective  Time as set  forth  substantially  in the  form of  Lockup  Agreement
attached  hereto as  Exhibit  C-2.  [***] of the shares of Parent  Common  Stock
issued to persons other than those listed on Schedule 1.9(a) shall be subject to
a [***] lockup provision from the Effective Time and all of the shares of Parent
Common Stock issuable to such persons other than those listed on Schedule 1.9(a)
shall be subject to the stock  restrictions set forth in substantially  the form
of Lockup  Agreement  attached  hereto as Exhibit C-1.  All future  transfers of
Parent Common Stock shall be made in accordance  with Parent's  Insider  Trading
Policy attached hereto as Exhibit H.






         I.11 No  Further  Ownership  Rights in  Company  Capital  Stock
No Further  Ownership  Rights in  Company  Capital  Stock.  All shares of Parent
Common Stock issued upon the surrender for exchange of shares of Company Capital
Stock in accordance  with the terms hereof  (including  any cash paid in respect
thereof) shall be deemed to have been issued in full  satisfaction of all rights
pertaining  to such  shares of  Company  Capital  Stock,  and there  shall be no
further registration of transfers on the records of the Surviving Corporation of
shares of Company Capital Stock which were outstanding  immediately prior to the
Effective Time. If, after the Effective Time,  Certificates are presented to the
Surviving  Corporation  for any reason,  they shall be canceled and exchanged as
provided in this Article I.

         I.12  Lost,  Stolen  or  Destroyed  Certificates.  In the event
any  Certificates  evidencing  shares of Company  Capital  Stock shall have been
lost,  stolen or destroyed,  the Exchange Agent shall issue in exchange for such
lost, stolen or destroyed Certificates,  upon the making of an affidavit of that
fact by the holder  thereof,  such  shares of Parent  Common  Stock and cash for
fractional shares, if any, as may be required pursuant to Section 1.6; provided,
however,  that Parent may, in its discretion and as a condition precedent to the
issuance  thereof,   require  the  owner  of  such  lost,  stolen  or  destroyed
Certificates  to  deliver  a bond in such  sum as it may  reasonably  direct  as
indemnity  against  any claim that may be made  against  Parent or the  Exchange
Agent with  respect  to the  Certificates  alleged to have been lost,  stolen or
destroyed.

         I.13 Tax Consequences.  It is intended  by the  parties  hereto that 
the Merger  shall  constitute  a tax-free  reorganization  within the meaning of
Section 368 of the Internal Revenue Code of 1986, as amended (the "Code").

         I.14 Taking of Necessary Action; Further Action. If, at any
time after the Effective Time, any such further action is necessary or desirable
to  carry  out  the  purposes  of  this  Agreement  and to  vest  the  Surviving
Corporation  with full right,  title and  possession  to all  assets,  property,
rights,  privileges,  powers and  franchises  of the Company and Merger Sub, the
officers and directors of the Company and Merger Sub are fully authorized in the
name of their  respective  corporations or otherwise to take, and will take, all
such lawful and necessary action.

         I.15     Restrictive Legends and Stop-Transfer Orders

                  (a) Legends.  Parent shall cause the legend set forth below or
legends  substantially  equivalent thereto, to be placed upon any certificate(s)
evidencing  ownership  of the Parent  Common  Stock  issued  pursuant to Section
1.6(a) above to the persons  listed on Schedule  5.10,  together  with any other
legends that may be required by state or federal securities laws:

                  THE SHARES  REPRESENTED BY THIS  CERTIFICATE  WERE ISSUED IN A
                  TRANSACTION  TO  WHICH  RULE  145  APPLIES  AND  MAY  ONLY  BE
                  TRANSFERRED  IN  CONFORMITY  WITH RULE 145(D) OR IN ACCORDANCE
                  WITH A WRITTEN  OPINION OF COUNSEL,  REASONABLY  ACCEPTABLE TO
                  THE ISSUER IN FORM AND SUBSTANCE, THAT SUCH TRANSFER IS EXEMPT
                  FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933.





In  addition,  Parent  shall  cause  the  legend  set  forth  below  or  legends
substantially   equivalent   thereto,  to  be  placed  upon  any  certificate(s)
evidencing  ownership of the Parent Common Stock issued to those persons  listed
on Schedule 1.9(a):

                  THE SHARES  REPRESENTED  BY THIS  CERTIFICATE  ARE  SUBJECT TO
                  CERTAIN  RIGHTS  OF  REPURCHASE  HELD  BY  THE  ISSUER  OR ITS
                  ASSIGNEE(S),  AS  SET  FORTH  IN THE  AGREEMENT  AND  PLAN  OF
                  REORGANIZATION  (THE  "AGREEMENT")   BETWEEN  THE  ISSUER  AND
                  NORTHWEST NEUROLOGIC, INC., A COPY OF WHICH MAY BE OBTAINED AT
                  THE PRINCIPAL OFFICE OF THE ISSUER.  THE SHARES REPRESENTED BY
                  THIS  CERTIFICATE  SHALL NOT BE  TRANSFERRED,  SOLD,  PLEDGED,
                  HYPOTHECATED OR OTHERWISE EXCHANGED PRIOR TO THE EXPIRATION OF
                  THE ISSUER'S  RIGHT OF REPURCHASE  SET FORTH IN SECTION 1.9 OF
                  THE AGREEMENT.

                  (b) Stop-Transfer  Notices. In order to ensure compliance with
the  restrictions  referred  to  herein,  Parent  may  issue  appropriate  "stop
transfer" instructions to its transfer agent.

                  (c) Refusal to Transfer.  Parent and its transfer  agent shall
not be required  (i) to transfer on its books any shares of Parent  Common Stock
that  have  been  sold  or  otherwise  transferred  in  violation  of any of the
provisions of this  Agreement or (ii) to treat as owner of such shares of Parent
Common Stock or to accord the right to vote or pay dividends to any purchaser or
other transferee to whom such shares shall have been so transferred.


                                   ARTICLE II

                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY
         The Company  hereby  represents  and warrants to Parent and Merger Sub,
subject to such  exceptions  as are  specifically  disclosed  in the  disclosure
letter  (referencing the appropriate  section number) supplied by the Company to
Parent prior to execution of this Agreement (the "Company  Schedules") and dated
as of the date hereof, as follows:






         II.1  Organization of the  Company.  The Company is a corporation  duly
organized  and  validly  existing  under  the laws of the State of  Oregon.  The
Company  has the  corporate  power  to own its  properties  and to  carry on its
business as now being  conducted.  The Company is duly  qualified to do business
and in good standing as a foreign  corporation in each jurisdiction in which the
failure to be so qualified would have a material adverse effect on the business,
assets  (including  intangible  assets),   financial  condition  or  results  of
operations  of the  Company  (hereinafter  referred  to as a  "Material  Adverse
Effect").  The Company has  delivered a true and correct copy of its Articles of
Incorporation and Bylaws, each as amended to date, to Parent.

         II.2     Company Capital Structure

                  (a) As of the Closing Date,  the  authorized  capital stock of
the Company shall consist of 10,000,000  shares of authorized  Common Stock,  of
which 591,250 shares are issued and outstanding, 10,000,000 shares of authorized
Preferred  Stock,  of which no shares are issued and  outstanding,  and no other
shares of Capital Stock. As of the Closing Date, the Company Capital Stock shall
be held of record  by the  persons,  with the  addresses  of  record  and in the
amounts set forth on Schedule 2.2(a).  All outstanding shares of Company Capital
Stock are duly authorized, validly issued, fully paid and non assessable and not
subject to preemptive  rights created by statute,  the Articles of Incorporation
or Bylaws of the Company or any  agreement to which the Company is a party or by
which it is bound.

                  (b) The Company has  reserved  158,750  shares of Common Stock
for issuance to employees and consultants pursuant to the Option Plan, of which,
as of the date  hereof and the  Closing  Date,  158,750  shares  are  subject to
outstanding,  unexercised  options  and no shares  remain  available  for future
grant. The Company has reserved 158,750 shares of Common Stock for issuance upon
exercise  of  outstanding  Company  Options  granted  outside  the Option  Plan.
Schedule 2.2(b) sets forth for each  outstanding  Company Option the name of the
holder of such option, the domicile address of such holder, the number of shares
of Common Stock  subject to such option,  the exercise  price of such option and
the vesting  schedule for such option,  including  the extent vested to date and
whether  the  exercisability  of such  option  will be  accelerated  and  become
exercisable by reason of the transactions contemplated by this Agreement. Except
as  described  in  Schedule  2.2(b),  all Company  Options  have been issued and
granted in all material  respects in compliance  with all applicable  securities
laws and all  other  applicable  legal  requirements.  Except  as  described  in
Schedules 2.2(a) and 2.2(b),  there are no outstanding shares of Company Capital
Stock or options,  warrants,  calls,  rights,  commitments  or agreements of any
character,  written or oral,  to which the  Company is a party or by which it is
bound obligating the Company to issue,  deliver,  sell, repurchase or redeem, or
cause to be issued, delivered,  sold, repurchased or redeemed, any shares of the
capital  stock of the  Company  or  obligating  the  Company  to grant,  extend,
accelerate  the vesting of, change the price of,  otherwise  amend or enter into
any such option, warrant, call, right,  commitment or agreement.  The holders of
Company Options have been or will be given, or shall have properly  waived,  any
required notice prior to the Merger.  As a result of the Merger,  Parent will be
the record  and sole  beneficial  owner of all  capital  stock of the  Surviving
Corporation and rights to acquire or receive such capital stock.

         II.3 Subsidiaries. The Company does not have and has never had any 
subsidiaries  or  affiliated  companies and does not otherwise own and has never
otherwise  owned any shares of capital  stock or any  interest  in, or  control,
directly or indirectly, any other corporation,  partnership,  association, joint
venture or other business entity.






         II.4  Authority.   Subject  only  to  the requisite   approval  of  the
Merger and this  Agreement by the  Company's  stockholders,  the Company has all
requisite  corporate  power and  authority to enter into this  Agreement  and to
consummate  the  transactions  contemplated  hereby.  The vote  required  of the
Company's  stockholders  to duly  approve  the  Merger and this  Agreement  is a
majority of all shares of Company  Capital Stock  entitled to vote thereon.  The
execution  and  delivery  of  this  Agreement  and  the   consummation   of  the
transactions  contemplated  hereby have been duly  authorized  by all  necessary
corporate action on the part of the Company, subject only to the approval of the
Merger by the  Company's  stockholders.  The  Company's  Board of Directors  has
unanimously approved the Merger and this Agreement. This Agreement has been duly
executed  and  delivered  by the Company and  constitutes  the valid and binding
obligation of the Company,  enforceable in accordance with its terms.  Except as
set forth on Schedule  2.4,  subject only to the approval of the Merger and this
Agreement by the  Company's  stockholders,  the  execution  and delivery of this
Agreement  by  the  Company  does  not,  and,  as of  the  Effective  Time,  the
consummation of the transactions contemplated hereby will not, conflict with, or
result in any violation of, or default under (with or without notice or lapse of
time,  or  both),  or give  rise  to a right  of  termination,  cancellation  or
acceleration  of any  obligation or loss of any benefit under (any such event, a
"Conflict") (i) any provision of the Articles of  Incorporation or Bylaws of the
Company or (ii) any mortgage,  indenture,  lease, contract or other agreement or
instrument,  permit,  concession,  franchise,  license, judgment, order, decree,
statute,  law,  ordinance,  rule or regulation  applicable to the Company or its
properties or assets. No consent,  waiver,  approval, order or authorization of,
or registration, declaration or filing with, any court, administrative agency or
commission  or other  federal,  state,  county,  local or  foreign  governmental
authority, instrumentality,  agency or commission ("Governmental Entity") or any
third party (so as not to trigger any  Conflict)  is required by or with respect
to the Company in connection  with the execution and delivery of this  Agreement
or the consummation of the transactions  contemplated hereby, except for (i) the
filing of the  Agreement of Merger with the Delaware and Oregon  Secretaries  of
State,  (ii)  such  consents,   waivers,  approvals,   orders,   authorizations,
registrations,  declarations  and  filings as may be required  under  applicable
federal  and state  securities  laws and (iii)  such  other  consents,  waivers,
authorizations,  filings,  approvals  and  registrations  which are set forth on
Schedule 2.4.

         II.5     Company Financial Statements

                  (a) Schedule 2.5 sets forth the  Company's  unaudited  balance
sheets as of December 31, 1997 (the "Balance  Sheet") and the related  unaudited
statement of operations for the 12-month  period then ended  (collectively,  the
"Company  Financials").  Except  as  disclosed  in  Schedule  2.5,  the  Company
Financials  are  correct in all  material  respects  and have been  prepared  in
accordance with generally accepted  accounting  principles ("GAAP") applied on a
basis  consistent  throughout  the periods  indicated and  consistent  with each
other, except that the Company Financials do not include footnotes.  As adjusted
by the  disclosures in Schedule 2.5, the Company  Financials  present fairly the
financial  condition  and  operating  results of the Company as of the dates and
during the periods indicated therein.






         II.6 No Undisclosed  Liabilities.  Except as set forth in Schedule 2.6,
the Company  does not have any  liability,  indebtedness,  obligation,  expense,
claim,  deficiency,  guaranty  or  endorsement  of any  type,  whether  accrued,
absolute, contingent, matured, unmatured or other (whether or not required to be
reflected in financial  statements in accordance with GAAP),  which individually
or in the aggregate,  (i) has not been  reflected in the Balance Sheet,  or (ii)
has not arisen in the ordinary  course of the Company's  business since the date
of the Balance Sheet, consistent with past practices, and is not material.

         II.7 No Changes.  Except as set forth in Schedule 2.7, since the date 
of the Balance Sheet, there has not been,  occurred or arisen any:

                  (a)  transaction by the Company except in the ordinary  course
of business as conducted on the date of the Balance  Sheet and  consistent  with
past practices;

                  (b)      amendments or changes to the Articles of 
Incorporation or Bylaws of the Company;

                  (c) capital  expenditure or commitment by the Company,  either
individually or in the aggregate, exceeding $10,000;

                  (d) destruction of, damage to or loss of any material  assets,
business or customer of the Company (whether or not covered by insurance);

                  (e)      labor trouble or claim of wrongful discharge or other
unlawful labor practice or action;

                  (f) change in accounting  methods or practices  (including any
change in depreciation or amortization policies or rates) by the Company;

                  (g)      revaluation by the Company of any of its assets;

                  (h)  declaration,  setting  aside or payment of a dividend  or
other  distribution  with respect to the capital  stock of the  Company,  or any
direct or indirect  redemption,  purchase or other acquisition by the Company of
any of its capital stock;

                  (i) increase in the salary or other compensation payable or to
become  payable to any of its officers,  directors,  employees,  consultants  or
advisors,  or the  declaration,  payment or commitment or obligation of any kind
for the payment of a bonus or other  additional  salary or  compensation  to any
such person except as otherwise contemplated by this Agreement;

                  (j) sale,  lease,  license or other  disposition of any of the
assets or properties of the Company,  except in the ordinary  course of business
as conducted on that date and consistent with past practices;





                  (k)  amendment  or  termination  of  any  material   contract,
agreement or license to which the Company is a party or by which it is bound;

                  (l) loan by the Company to any person or entity,  incurring by
the  Company  of  any   indebtedness,   guaranteeing   by  the  Company  of  any
indebtedness,  issuance  or  sale  of any  debt  securities  of the  Company  or
guaranteeing of any debt securities of others,  except for advances to employees
for travel and business expenses in the ordinary course of business,  consistent
with past practices;

                  (m) waiver or  release  of any right or claim of the  Company,
including  any write-off or other  compromise  of any account  receivable of the
Company;

                  (n)  commencement  or notice or threat of  commencement of any
lawsuit or proceeding against or investigation of the Company or its affairs;

                  (o) notice of any claim of  ownership  by a third party of the
Company's  Intellectual  Property  (as  defined  in  Section  2.11  below) or of
infringement by the Company of any third party's Intellectual Property rights;

                  (p)  issuance  or sale by the  Company of any of its shares of
capital stock, or securities exchangeable,  convertible or exercisable therefor,
or of any other of its securities;

                  (q) change in pricing, royalties or reimbursement rates set or
charged by the Company to its customers or licensees or in pricing, royalties or
reimbursement  rates set or charged by persons  who have  licensed  Intellectual
Property to the Company;

                  (r) event or condition of any  character  that has or could be
reasonably expected to have a Material Adverse Effect on the Company; or

                  (s)  negotiation or agreement by the Company or any officer or
employees thereof to do any of the things described in the preceding clauses (a)
through  (r)  (other  than  negotiations  with  Parent  and its  representatives
regarding the transactions contemplated by this Agreement).

         II.8     Tax and Other Returns and Reports

                  (a) Definition of Taxes.  For the purposes of this  Agreement,
"Tax" or,  collectively,  "Taxes",  means any and all federal,  state, local and
foreign taxes, assessments and other governmental charges,  duties,  impositions
and  liabilities,  including  taxes based upon or  measured  by gross  receipts,
income,  profits,  sales,  use and  occupation,  and value  added,  ad  valorem,
transfer,  franchise,  withholding,  payroll, recapture,  employment, excise and
property taxes, together with all interest, penalties and additions imposed with
respect to such amounts and any obligations under any agreements or arrangements
with any other person with respect to such amounts and  including  any liability
for taxes of a predecessor entity.






                  (b)      Tax Returns and Audits.  Except as set forth in 
Schedule 2.8:

                           (i)      The Company as of the Effective Time will
have prepared and filed all required federal,  state, local and foreign returns,
estimates,  information  statements and reports ("Returns")  relating to any and
all Taxes  concerning or  attributable to the Company or its operations and such
Returns  are true and  correct  and  have  been  completed  in  accordance  with
applicable law.

                           (ii) The Company as of the Effective  Time:  (A) will
have paid or accrued all Taxes
it is required to pay or accrue and (B) will have  withheld  with respect to its
employees  all  federal  and state  income  taxes,  FICA,  FUTA and other  Taxes
required to be withheld.

                           (iii)  The  Company  has not been  delinquent  in the
payment of any Tax nor is there any
Tax deficiency  outstanding,  proposed or assessed against the Company,  nor has
the Company  executed any waiver of any statute of  limitations  on or extending
the period for the assessment or collection of any Tax.

                           (iv)     No audit or other examination of any Return 
     of the Company is currently in progress,  nor has the Company been notified
of any request for such an audit or other examination.

                           (v) The  Company  does not have any  liabilities  for
unpaid  federal,  state,  local and foreign Taxes which have not been accrued or
reserved against in accordance with GAAP on the Balance Sheet,  whether asserted
or unasserted,  contingent or otherwise, and the Company has no knowledge of any
basis for the assertion of any such liability  attributable to the Company,  its
assets or operations.

                           (vi) The Company has provided to Parent copies of all
federal and state income and all state sales and use Tax Returns for all periods
since the date of Company's incorporation.

                           (vii) There are (and as of immediately  following the
Effective  Time  there will be) no liens,  pledges,  charges,  claims,  security
interests  or other  encumbrances  of any sort  ("Liens")  on the  assets of the
Company relating to or attributable to Taxes.

                           (viii) The Company has no  knowledge of any basis for
the assertion of any claim relating or attributable to Taxes which, if adversely
determined, would result in any Lien on the assets of the Company.

                           (ix)     None of the Company's assets are treated as
"tax-exempt use property" within the meaning of Section 168(h) of the Code.






                           (x)      As of the Effective Time, there will not be
any contract,  agreement, plan or arrangement,  including but not limited to the
provisions of this  Agreement,  covering any employee or former  employee of the
Company that,  individually or  collectively,  could give rise to the payment of
any amount that would not be  deductible  pursuant to Section 280G or 162 of the
Code.
                           (xi)     The Company has not filed any consent 
agreement  under Section 341(f) of the Code or agreed to have Section  341(f)(2)
of the Code apply to any  disposition  of a subsection  (f) asset (as defined in
Section 341(f)(4) of the Code) owned by the Company.

                           (xii) The  Company is not a party to a tax sharing or
allocation  agreement  nor  does  the  Company  owe any  amount  under  any such
agreement.

                           (xiii) The  Company  is not,  and has not been at any
time, a "United States real property holding  corporation" within the meaning of
Section 897(c)(2) of the Code.

                           (xiv)  The  Company's  tax  basis in its  assets  for
purposes of determining its future amortization,  depreciation and other federal
income tax  deductions  is  accurately  reflected on the Company's tax books and
records.

         II.9 Restrictions on Business  ActivitiesII.9  Restrictions on Business
ActivitiesII.9  Restrictions  on  Business  Activities.  There  is no  agreement
(noncompete or otherwise),  commitment, judgment, injunction, order or decree to
which the Company is a party or otherwise  binding upon the Company which has or
reasonably  could be expected to have the effect of prohibiting or impairing any
business  practice of the  Company,  any  acquisition  of property  (tangible or
intangible)  by the Company or the conduct of business by the  Company.  Without
limiting the  foregoing,  the Company has not entered into any  agreement  under
which  the  Company  is  restricted   from   selling,   licensing  or  otherwise
distributing  any of its products to any class of customers,  in any  geographic
area, during any period of time or in any segment of the market.

         II.10    Title to  Properties;  Absence of Liens and  EncumbrancesII.10
                  Title to  Properties;  Absence of Liens and  EncumbrancesII.10
                  Title to Properties; Absence of Liens and Encumbrances.

                  (a) The Company owns no real  property,  nor has it ever owned
any real  property.  Schedule  2.10(a)  sets  forth a list of all real  property
currently,  or at any time in the past,  leased by the Company,  the name of the
lessor,  the date of the lease and each  amendment  thereto and, with respect to
any current lease,  the aggregate  annual rental and/or other fees payable under
any such lease. All such current leases are in full force and effect,  are valid
and effective in accordance with their respective terms, and there is not, under
any of such  leases,  any  existing  default or event of default (or event which
with notice or lapse of time, or both, would constitute a default).






                  (b) The  Company  has good and valid title to, or, in the case
of leased  properties  and  assets,  valid  leasehold  interests  in, all of its
tangible  properties and assets,  real, personal and mixed, used or held for use
in  its  business,   free  and  clear  of  any  Liens  (as  defined  in  Section
2.8(b)(vii)),  except as  reflected  in the  Company  Financials  or in Schedule
2.10(b)  and  except  for  liens  for  taxes  not yet due and  payable  and such
imperfections  of title and  encumbrances,  if any,  which are not  material  in
character, amount or extent, and which do not materially detract from the value,
or materially interfere with the present use, of the property subject thereto or
affected thereby.

         II.11 Intellectual Property

                  (a) The Company  owns,  or is licensed or otherwise  possesses
legally enforceable rights to use, all patents, trademarks, trade names, service
marks,  copyrights,  and  any  applications  therefor,   maskworks,  net  lists,
schematics, technology, know-how, computer software programs or applications (in
both source code and object code form),  and tangible or intangible  proprietary
information  or  material  that  are  used in the  business  of the  Company  as
currently  conducted or as proposed to be conducted by the Company (the "Company
Intellectual Property Rights").

                  (b)  Schedule  2.11(a)  sets  forth  a  complete  list  of all
patents, registered and material unregistered trademarks, registered copyrights,
trade names and service marks,  and any applications  therefor,  included in the
Company  Intellectual  Property Rights,  and specifies,  where  applicable,  the
jurisdictions  in which each such Company  Intellectual  Property Right has been
issued  or  registered  or  in  which  an  application  for  such  issuance  and
registration   has  been  filed,   including  the  respective   registration  or
application  numbers and the names of all registered  owners.  Schedule  2.11(b)
sets forth a complete list of all licenses,  sublicenses and other agreements as
to which the  Company is a party and  pursuant to which the Company or any other
person is authorized  to use any Company  Intellectual  Property  Right or trade
secret of the  Company,  and includes  the  identity of all parties  thereto,  a
description of the nature and subject matter thereof,  the applicable royalty or
other fees and the term thereof. The execution and delivery of this Agreement by
the Company, and the consummation of the transactions  contemplated hereby, will
neither  cause the Company to be in violation or default under any such license,
sublicense  or  agreement,  nor  entitle  any other  party to any such  license,
sublicense  or  agreement to terminate  or modify such  license,  sublicense  or
agreement.  Except as set forth in Schedules 2.11(a) or 2.11(b),  the Company is
the sole and exclusive owner or licensee of, with all right,  title and interest
in  and  to  (free  and  clear  of  any  liens  or  encumbrances),  the  Company
Intellectual  Property  Rights,  and has sole and  exclusive  rights (and is not
contractually  obligated to pay any  compensation  to any third party in respect
thereof) to the use thereof or the material  covered  thereby in connection with
the services or products in respect of which the Company  Intellectual  Property
Rights are being used.






                  (c)  No  claims  with  respect  to  the  Company  Intellectual
Property  Rights  have  been  asserted  or  are,  to  the  Company's  knowledge,
threatened  by any person,  nor are there any valid grounds for any such claims,
(i) to the effect that the  manufacture,  sale,  licensing  or use of any of the
products of the Company infringes on any copyright,  patent, trade mark, service
mark,  trade  secret or other  proprietary  right,  (ii)  against the use by the
Company  of  any  trademarks,   service  marks,   trade  names,  trade  secrets,
copyrights,  maskworks,  patents,  technology,  know-how  or  computer  software
programs and applications used in the Company's business as currently  conducted
or as  proposed  to be  conducted  by the  Company,  or  (iii)  challenging  the
ownership  by the  Company,  validity  or  effectiveness  of any of the  Company
Intellectual  Property  Rights.  All  registered  trademarks,  service marks and
copyrights  held by the  Company are valid and  subsisting.  The Company has not
infringed, and the business of the Company as currently conducted or as proposed
to be conducted does not infringe,  any copyright,  patent,  trademark,  service
mark, trade secret or other  proprietary  right of any third party.  There is no
material  unauthorized  use,  infringement  or  misappropriation  of  any of the
Company Intellectual Property Rights by any third party,  including any employee
or former  employee of the Company.  No Company  Intellectual  Property Right or
product of the Company or any of its  subsidiaries is subject to any outstanding
decree, order, judgment, or stipulation  restricting in any manner the licensing
thereof by the  Company.  The  Company  has taken all  reasonable  measures  and
precautions  to protect and maintain the  confidentiality,  secrecy and value of
the  Company  Intellectual  Property  Rights.  Except as set  forth on  Schedule
2.11(c),  each current and former  employee,  consultant  or  contractor  of the
Company has executed a proprietary  information  and  confidentiality  agreement
substantially in the Company's  standard forms and in any event  restricting the
use and  disclosure of the Company  Intellectual  Property and providing for the
assignment  to the Company of Company  Intellectual  Property  developed by such
employees,  consultants and  contractors.  All software  included in the Company
Intellectual  Property  Rights is original  with the Company and has been either
created by employees of the Company on a  work-for-hire  basis or by consultants
or contractors  who have created such software  themselves and have assigned all
rights they may have had in such software to the Company.

         II.12 Agreements,  Contracts and CommitmentsII.12 Agreements, Contracts
and CommitmentsII.12 Agreements,  Contracts and Commitments. Except as set forth
on  Schedule  2.12(a),  the Company  does not have,  is not a party to nor is it
bound by:

                           (i)      any collective bargaining agreements,

                           (ii)     any agreements or arrangements that contain 
any severance pay or post-employment liabilities or obligations,

                           (iii)  any  bonus,  deferred  compensation,  pension,
profit  sharing or  retirement  plans,  or any other  employee  benefit plans or
arrangements,

                           (iv)     any employment or consulting agreement, 
contract or commitment with an employee or individual  consultant or salesperson
or any  consulting or sales  agreement,  contract or commitment  under which any
firm or other organization provides services to the Company,

(v) any agreement or plan, including, without limitation, any stock option plan,
stock  appreciation  rights plan or stock  purchase plan, any of the benefits of
which  will  be  increased,  or  the  vesting  of  benefits  of  which  will  be
accelerated,  by the occurrence of any of the transactions  contemplated by this
Agreement or the value of any of the benefits of which will be calculated on the
basis of any of the transactions contemplated by this Agreement,

                           (vi)     any fidelity or surety bond or completion 
bond,






                           (vii) any lease of personal  property  having a value
individually in excess of $10,000,

                           (viii)   any agreement of indemnification or 
guaranty,

                           (ix)     any agreement, contract or commitment 
containing  any  covenant  limiting  the freedom of the Company to engage in any
line of business or to compete with any person,

                           (x)      any agreement, contract or commitment 
relating to capital  expenditures  and  involving  future  payments in excess of
$10,000,

                           (xi)     any agreement, contract or commitment
relating to the  disposition  or  acquisition  of assets or any  interest in any
business enterprise outside the ordinary course of the Company's business,

                           (xii)  any  mortgages,  indentures,  loans or  credit
agreements,  security agreements or other agreements or instruments  relating to
the borrowing of money or extension of credit,  including guaranties referred to
in clause (viii) hereof,
                           (xiii)  any  purchase   order  or  contract  for  the
purchase of raw materials involving $10,000 or more,

                           (xiv)    any construction contracts,

                           (xv)     any distribution, joint marketing or 
development agreement,

                           (xvi) any  contract  requiring  that the Company give
any notice,  obtain any consent,  or provide any information to any person prior
to consummating the Merger,

                           (xvii) any contract involving a governmental body, to
which any governmental  body is a party,  under which any governmental  body has
any  rights  or   obligations,   or  indirectly  or  directly   benefitting  any
governmental body,

                           (xviii) any  agreement  pursuant to which the Company
has  granted or may grant in the  future,  to any party,  a license or option or
other right to use or acquire any  technology or Company  Intellectual  Property
Right, or

                           (xix) any other  agreement,  contract  or  commitment
that involves $10,000 or more or is not cancelable without penalty within thirty
(30) days,  or that could  reasonably  be  expected  to have a material  adverse
effect on the business condition,  assets,  liabilities or financial performance
of the Company or any of the transactions contemplated by this Agreement.






Except for such alleged breaches, violations and defaults, and events that would
constitute  a breach,  violation  or default  with the lapse of time,  giving of
notice,  or both,  as are all noted in  Schedule  2.12(b),  the  Company has not
breached,  violated or defaulted under, or received notice that it has breached,
violated or defaulted  under,  any of the terms or conditions of any  agreement,
contract or commitment  required to be set forth on Schedule 2.12(a) or Schedule
2.11(b)  (any such  agreement,  contract  or  commitment,  a  "Contract").  Each
Contract is in full force and effect and is enforceable  in accordance  with its
terms and, except as otherwise  disclosed in Schedule 2.12(b), is not subject to
any default thereunder of which the Company has knowledge by any party obligated
to the Company pursuant thereto.  The Contracts  collectively  constitute all of
the  contracts  necessary  to enable the Company to conduct its  business in the
manner in which it is currently being conducted and in the manner in which it is
proposed to be conducted.

         II.13    Interested    Party    Transactions.  Except as set forth on 
Schedule  2.13,  no officer,  director or  stockholder  of the Company  (nor any
ancestor,  sibling,  descendant or spouse of any of such persons,  or any trust,
partnership  or  corporation  in  which  any of such  persons  has or has had an
interest),  has or has had, directly or indirectly,  (i) an economic interest in
any entity which furnished or sold, or furnishes or sells,  services or products
that the Company  furnishes  or sells,  or proposes to furnish or sell,  (ii) an
economic  interest in any entity that  purchases  from or sells or furnishes to,
the  Company,  any  goods or  services  or (iii) a  beneficial  interest  in any
contract  or  agreement  set forth in  Schedule  2.12(a)  or  Schedule  2.11(b);
provided,  that  ownership of no more than one percent  (1%) of the  outstanding
voting stock of a publicly traded  corporation  shall not be deemed an "economic
interest in any entity" for purposes of this Section 2.13.

         II.14  Compliance with Laws.  The Company has complied in all material
respects  with,  is not in  violation  of, and has not  received  any notices of
violation with respect to, any foreign,  federal, state or local statute, law or
regulation.

         II.15 Litigation.  Except as set forth in Schedule 2.15,  there is no
action,  suit or proceeding of any nature pending or to the Company's  knowledge
threatened  against  the  Company,  its  properties  or any of its  officers  or
directors,  in their  respective  capacities  as such.  Except  as set  forth in
Schedule 2.15, to the Company's knowledge,  there is no investigation pending or
threatened  against  the  Company,  its  properties  or any of its  officers  or
directors by or before any governmental  entity.  Schedule 2.15 sets forth, with
respect to any pending or threatened action, suit,  proceeding or investigation,
the forum,  the parties  thereto,  the subject  matter thereof and the amount of
damages claimed or other remedy  requested.  No  governmental  entity has at any
time  challenged  or questioned  the legal right of the Company to  manufacture,
offer or sell any of its products in the present manner or style thereof.






         II.16  Insurance.  With  respect to the insurance policies and fidelity
bonds  covering  the  assets,  business,  equipment,   properties,   operations,
employees,  officers  and  directors  of the  Company,  there is no claim by the
Company  pending  under any of such  policies or bonds as to which  coverage has
been  questioned,  denied or disputed by the  underwriters  of such  policies or
bonds.  All premiums due and payable under all such policies and bonds have been
paid and the Company is otherwise in material  compliance with the terms of such
policies and bonds (or other policies and bonds providing  substantially similar
insurance coverage).  The Company has no knowledge of any threatened termination
of, or material premium increase with respect to, any of such policies.

         II.17 Minute Books. The minute books of the Company made available to
counsel  for Parent  are the only  minute  books of the  Company  and  contain a
reasonably accurate summary of all meetings of directors (or committees thereof)
and  stockholders or actions by written consent since the time of  incorporation
of the Company.

         II.18     Environmental Matters

                  (a) "Environmental  Claim" means any notice, claim, act, cause
of action or investigation by any person alleging potential liability (including
potential  liability  for  investigatory  costs,  cleanup  costs,   governmental
response costs, natural resources damages,  property damages,  personal injuries
or penalties)  arising out of, based on or resulting  from (i) the presence,  or
release  into  the  environment,  of any  Hazardous  Materials  (as  hereinafter
defined) or (ii) any violation, or alleged violation, of any Environmental Laws.
"Environmental  Laws"  means all  federal,  state,  local and  foreign  laws and
regulations  relating to pollution or the  environment  (including  ambient air,
surface  water,  ground  water,  land  surface  or  subsurface  strata)  or  the
protection  of  human  health,   including  laws  and  regulations  relating  to
emissions,  discharges,  releases or threatened releases of Hazardous Materials,
or  otherwise  relating  to  the  manufacture,  processing,  distribution,  use,
treatment,  storage,  disposal,  transport or handling of  Hazardous  Materials.
"Hazardous Materials" means chemicals, pollutants,  contaminants,  wastes, toxic
substances, radioactive and biological materials,  asbestos-containing materials
(ACM),  hazardous  substances,  petroleum and petroleum products or any fraction
thereof.

                  (b)  The  Company  has  been  and  is  in  compliance   (which
compliance  includes,  but is not limited to, the  possession of all permits and
other governmental  authorizations required under applicable  Environmental Laws
and compliance with the terms and conditions  thereof) in all material  respects
with all  Environmental  Laws and the Company has not received any notice of any
alleged claim,  violation of or liability under any Environmental Laws which has
not heretofore been cured or for which there is any remaining liability;

                  (c) The Company has not received  notice of any  Environmental
Claim filed or  threatened  against  it, or against  any person or entity  whose
liability for any Environmental Claim the Company has retained or assumed either
contractually  or by operation of law and there are no past or present  actions,
activities,   circumstances,   conditions,   events  or  incidents,  that  could
reasonably be expected to form the basis of any Environmental  Claim against the
Company,  the business thereof,  or against any person or entity whose liability
for  any  Environmental  Claim  the  Company  has  retained  or  assumed  either
contractually or by operation of law;






                  (d) The  Company has not  disposed  of,  emitted,  discharged,
handled, stored, transported, used or released any Hazardous Materials, arranged
for the disposal,  discharge,  storage or release of any Hazardous Materials, or
exposed any employee or other individual to any Hazardous Materials or condition
so as to give rise to any liability or corrective or remedial  obligation  under
any Environmental Laws; and

                  (e) To the  actual  knowledge  of the  Company,  no  Hazardous
Materials  are present in or on any  premises  leased or used at any time by the
Company  or for its  business,  and no  reasonable  likelihood  exists  that any
Hazardous Materials will come to be present in or on any such premises leased or
used at any time by the  Company  for its  business,  so as to give  rise to any
material liability or corrective or remedial  obligation under any Environmental
Laws.

         II.19 Brokers' and Finders' Fees;  Third Party  ExpensesII.19  Brokers'
and Finders' Fees; Third Party  ExpensesII.19  Brokers' and Finders' Fees; Third
Party  Expenses.  Except as set forth on  Schedule  2.19,  the  Company  has not
incurred, nor will it incur, directly or indirectly, any liability for brokerage
or finders'  fees or agents'  commissions  or any similar  charges in connection
with this Agreement or any transaction  contemplated hereby.  Schedule 2.19 sets
forth the principal terms and conditions of any agreement, written or oral, with
respect  to such  fees.  Schedule  2.19 also sets  forth the  Company's  current
reasonable  estimate of all Third  Party  Expenses  (as defined in Section  5.4)
expected to be incurred by the Company in connection  with the  negotiation  and
effectuation of the terms and conditions of this Agreement and the  transactions
contemplated hereby.

         II.20    Employee Matters and Benefit Plans

                  (a)  Definitions.  With the  exception  of the  definition  of
"Affiliate" set forth in Section  2.20(a)(i) below (which definition shall apply
only to this Section 2.20), for purposes of this Agreement,  the following terms
shall have the meanings set forth below:

                           (i)      "Affiliate" shall mean any other person or 
entity  under  common  control  with the  Company  within the meaning of Section
414(b), (c), (m) or (o) of the Code and the regulations thereunder;

                           (ii)  "ERISA"  shall  mean  the  Employee  Retirement
Income Security Act of 1974, as amended;

                           (iii)  "Company  Employee  Plan"  shall  refer to any
plan,  program,  policy,  practice,  contract,  agreement  or other  arrangement
providing for  compensation,  severance,  termination pay,  performance  awards,
stock or  stock-related  awards,  fringe benefits or other employee  benefits or
remuneration  of any kind,  whether  formal or informal,  funded or unfunded and
whether or not legally binding,  including  without  limitation,  each "employee
benefit plan",  within the meaning of Section 3(3) of ERISA which is or has been
maintained,  contributed to, or required to be contributed to, by the Company or
any Affiliate for the benefit of any "Employee" (as defined below), and pursuant
to which the Company or any  Affiliate  has or may have any  material  liability
contingent or otherwise;





                           (iv) "Employee"  shall mean any current,  former,  or
retired employee, officer, or director of the Company or any Affiliate;

                           (v)      "Employee Agreement" shall refer to each 
management,   employment,  severance,  consulting,   relocation,   repatriation,
expatriation,  visas,  work permit or similar  agreement or contract between the
Company or any Affiliate and any Employee or consultant;

                           (vi)     "IRS" shall mean the Internal Revenue 
Service;

                           (vii)  "Multiemployer  Plan" shall mean any  "Pension
Plan" (as defined below) which is a "multiemployer  plan", as defined in Section
3(37) of ERISA; and

                           (viii)  "Pension  Plan" shall  refer to each  Company
Employee Plan which is an "employee pension benefit plan", within the meaning of
Section 3(2) of ERISA.

                  (b)  Schedule.  Schedule  2.20(b)  contains  an  accurate  and
complete  list of each  Company  Employee  Plan  and  each  Employee  Agreement,
together with a schedule of all liabilities,  whether or not accrued, under each
such Company Employee Plan or Employee Agreement.  The Company does not have any
plan or commitment, whether legally binding or not, to establish any new Company
Employee  Plan or Employee  Agreement,  to modify any Company  Employee  Plan or
Employee  Agreement (except to the extent required by law or to conform any such
Company  Employee  Plan  or  Employee  Agreement  to  the  requirements  of  any
applicable law, in each case as previously disclosed to Parent in writing, or as
required  by this  Agreement),  or to enter into any  Company  Employee  Plan or
Employee  Agreement,  nor does it have any  intention or commitment to do any of
the foregoing.

                  (c) Documents.  The Company has provided to Parent (i) correct
and  complete  copies of all  documents  embodying  or relating to each  Company
Employee Plan and each Employee  Agreement  including all amendments thereto and
written   interpretations   thereof;  (ii)  the  most  recent  annual  actuarial
valuations,  if any,  prepared for each Company  Employee Plan;  (iii) the three
most recent  annual  reports  (Series 5500 and all schedules  thereto),  if any,
required under ERISA or the Code in connection  with each Company  Employee Plan
or related trust;  (iv) if the Company Employee Plan is funded,  the most recent
annual and periodic  accounting of Company  Employee  Plan assets;  (v) the most
recent  summary  plan  description  together  with the most  recent  summary  of
material  modifications,  if any,  required  under  ERISA  with  respect to each
Company Employee Plan; (vi) all IRS  determination  letters and rulings relating
to Company Employee Plans and copies of all applications and  correspondence  to
or from the IRS or the  Department  of Labor ("DOL") with respect to any Company
Employee Plan;  (vii) all  communications  material to any Employee or Employees
relating to any Company  Employee Plan and any proposed  Company Employee Plans,
in  each  case,  relating  to  any  amendments,  terminations,   establishments,
increases  or  decreases  in  benefits,  acceleration  of  payments  or  vesting
schedules or other  events  which would result in any material  liability to the
Company;  and (viii) all registration  statements and  prospectuses  prepared in
connection with each Company Employee Plan.






                  (d) Employee Plan Compliance.  Except as set forth on Schedule
2.20(d),  (i) the Company has performed in all material respects all obligations
required  to be  performed  by it under each  Company  Employee  Plan,  and each
Company  Employee  Plan has been  established  and  maintained  in all  material
respects in  accordance  with its terms and in  compliance  with all  applicable
laws,  statutes,  orders,  rules and  regulations,  including but not limited to
ERISA or the Code;  (ii) no  "prohibited  transaction",  within  the  meaning of
Section 4975 of the Code or Section 406 of ERISA,  has occurred  with respect to
any Company Employee Plan; (iii) there are no actions,  suits or claims pending,
or, to the  knowledge  of the Company,  threatened  or  anticipated  (other than
routine  claims for benefits)  against any Company  Employee Plan or against the
assets of any Company  Employee Plan; and (iv) each Company Employee Plan can be
amended,  terminated  or  otherwise  discontinued  after the  Effective  Time in
accordance with its terms,  without  liability to the Company,  Parent or any of
its Affiliates (other than ordinary  administration  expenses typically incurred
in a termination  event); (v) there are no inquiries or proceedings  pending or,
to the knowledge of the Company or any affiliates,  threatened by the IRS or DOL
with respect to any Company  Employee Plan; and (vi) neither the Company nor any
Affiliate is subject to any penalty or tax with respect to any Company  Employee
Plan under Section 402(i) of ERISA or Section 4975 through 4980 of the Code.

                  (e) Pension Plans.  The Company does not now, nor has it ever,
maintained,  established,  sponsored,  participated  in, or contributed  to, any
Pension Plan which is subject to Part 3 of Subtitle B of Title I of ERISA, Title
IV of ERISA or Section 412 of the Code.

                  (f)   Multiemployer   Plans.   At  no  time  has  the  Company
contributed to or been requested to contribute to any Multiemployer Plan.

                  (g) No  Post-Employment  Obligations.  Except  as set forth in
Schedule  2.20(g),  no Company  Employee Plan provides,  or has any liability to
provide, life insurance, medical or other employee benefits to any Employee upon
his or her retirement or termination of employment for any reason, except as may
be  required by statute,  and the  Company  has never  represented,  promised or
contracted   (whether  in  oral  or  written  form)  to  any  Employee   (either
individually or to Employees as a group) that such Employee(s) would be provided
with life  insurance,  medical or other  employee  welfare  benefits  upon their
retirement  or  termination  of  employment,  except to the extent  required  by
statute.

                  (h)      Effect of Transaction.

                           (i)      Except as set forth on Schedule 2.20(h)(i), 
the  execution  of this  Agreement  and  the  consummation  of the  transactions
contemplated  hereby  will  not  (either  alone or upon  the  occurrence  of any
additional or subsequent  events) constitute an event under any Company Employee
Plan, Employee  Agreement,  trust or loan that will or may result in any payment
(whether  of  severance  pay  or   otherwise),   acceleration,   forgiveness  of
indebtedness,  vesting, distribution, increase in benefits or obligation to fund
benefits with respect to any Employee.






                           (ii)     Except as set forth on Schedule 2.20(h)(ii),
no payment or benefit  which will or may be made by the Company or Parent or any
of  their   respective   affiliates   with  respect  to  any  Employee  will  be
characterized as an "excess  parachute  payment",  within the meaning of Section
280G(b)(1) of the Code.

                  (i)  Employment  Matters.  The Company (i) is in compliance in
all material  respects with all  applicable  foreign,  federal,  state and local
laws, rules and regulations respecting employment,  employment practices,  terms
and conditions of employment and wages and hours,  in each case, with respect to
Employees;  (ii) has withheld all amounts  required by law or by agreement to be
withheld from the wages, salaries and other payments to Employees;  (iii) is not
liable  for any  arrears  of wages or any taxes or any  penalty  for  failure to
comply with any of the foregoing;  and (iv) is not liable for any payment to any
trust or other fund or to any  governmental or  administrative  authority,  with
respect to unemployment compensation benefits, social security or other benefits
or  obligations  for  Employees  (other than routine  payments to be made in the
normal course of business and consistent with past practice).

                  (j)  Labor.  No work  stoppage  or labor  strike  against  the
Company is pending or, to the best knowledge of the Company, threatened.  Except
as set forth in  Schedule  2.20(j),  the  Company is not  involved in or, to the
knowledge of the Company,  threatened  with,  any labor dispute,  grievance,  or
litigation  relating to labor,  safety or  discrimination  matters involving any
Employee,  including,  without limitation,  charges of unfair labor practices or
discrimination complaints,  which, if adversely determined,  would, individually
or in the aggregate, result in liability to the Company. Neither the Company nor
any of its  subsidiaries  has engaged in any unfair labor  practices  within the
meaning of the National Labor Relations Act which would,  individually or in the
aggregate,  directly or indirectly result in a liability to the Company.  Except
as set forth in Schedule 2.20(j), the Company is not presently,  nor has it been
in the past,  a party to, or bound by, any  collective  bargaining  agreement or
union contract with respect to Employees and no collective  bargaining agreement
is being negotiated by the Company.

         II.21 Tax  Treatment.  To the Company's knowledge,  neither the Company
nor any of its directors,  officers or  stockholders  has taken any action which
the Company is aware would interfere with the tax-free status of the Merger as a
reorganization under Section 368 of the Code.

         II.22 No  Existing  Discussions.  Neither the  Company  nor  any of its
representatives,  agents, or employees are engaged,  directly or indirectly,  in
any discussions or negotiations  with any other person relating to any action or
activity proscribed by Section 4.2 hereof.

         II.23  Vote  Required.   The affirmative  vote of the holders of a
majority of the shares of Company  Common Stock  outstanding is the only vote of
the holders of any class or series of the Company's  Capital Stock  necessary to
approve this Agreement,  the Merger and the other  transactions  contemplated by
this Agreement.






         II.24  Representations   CompleteII.24   Representations  CompleteII.24
Representations  Complete. None of the representations or warranties made by the
Company (as modified by the Company  Schedules),  nor any statement  made in any
schedule or certificate furnished by the Company pursuant to this Agreement,  or
furnished  in or in  connection  with  documents  mailed  or  delivered  to  the
stockholders of the Company in connection with soliciting  their consent to this
Agreement and the Merger,  contains or will contain at the Effective  Time,  any
untrue statement of a material fact, or omits or will omit at the Effective Time
to state any material fact necessary in order to make the  statements  contained
herein or therein,  in the light of the  circumstances  under  which  made,  not
misleading.


                                   ARTICLE III

             REPRESENTATIONS AND WARRANTIES OF PARENT AND MERGER SUB

         Parent and Merger Sub represent and warrant to the Company as follows:

         III.1 Organization,  Standing and Power Organization,  Standing  and 
Power.  Parent is a corporation  duly  organized,  validly  existing and in good
standing  under the laws of the State of Delaware.  Merger Sub is a  corporation
duly  organized,  validly  existing and in good  standing  under the laws of the
State of Delaware.  Each of Parent and Merger Sub has the corporate power to own
its properties  and to carry on its business as now being  conducted and is duly
qualified to do business and is in good standing in each  jurisdiction  in which
the failure to be so qualified  would have a material  adverse  effect on Parent
and Merger Sub as a whole.

         III.2 Authority.  Parent and Merger Sub have all requisite  corporate
power  and  authority  to  enter  into  this  Agreement  and to  consummate  the
transactions  contemplated  hereby. The execution and delivery of this Agreement
and the  consummation  of the  transactions  contemplated  hereby have been duly
authorized  by all necessary  corporate  action on the part of Parent and Merger
Sub.  This  Agreement  has been duly executed and delivered by Parent and Merger
Sub and constitutes the valid and binding  obligations of Parent and Merger Sub,
enforceable in accordance with its terms.

         III.3    Capital Structure

                  (a The  authorized  stock of  Parent  consists  of  50,000,000
shares of Common Stock, of which approximately 17,707,815 shares were issued and
outstanding  as of February 28, 1998, and 5,000,000  shares of Preferred  Stock,
none of which is issued or outstanding.  The authorized  capital stock of Merger
Sub consists of 1,000 shares of Common Stock,  1,000 shares of which,  as of the
date hereof,  are issued and outstanding and are held by Parent. All such shares
have been duly authorized,  and all such issued and outstanding shares have been
validly issued,  are fully paid and  nonassessable  and are free of any liens or
encumbrances other than any liens or encumbrances created by or imposed upon the
holders  thereof.  The  outstanding  stock of  Merger  Sub is free of liens  and
encumbrances.






                  (b The shares of Parent Common Stock to be issued  pursuant to
the Merger,  when issued, will be duly authorized,  validly issued,  fully paid,
nonassessable  and issued in  compliance  with  applicable  federal,  Oregon and
Delaware securities laws.

         III.4 SEC Documents;  Parent Financial  Statements. Parent has
furnished  or made  available  to the Company  true and  complete  copies of all
reports or registration  statements filed by it with the Securities and Exchange
Commission (the "SEC") since December 31, 1996, all in the form so filed (all of
the foregoing  being  collectively  referred to as the "SEC  Documents").  As of
their  respective  filing  dates,  the SEC  Documents  complied in all  material
respects with the  requirements  of the Securities Act of 1933 (the  "Securities
Act") or the Securities  Exchange Act of 1934 (the  "Exchange  Act") as the case
may be,  and none of the SEC  Documents  contained  any  untrue  statement  of a
material fact or omitted to state a material fact required to be stated  therein
or necessary to make the statements made therein,  in light of the circumstances
in which they were made,  not  misleading,  except to the extent  corrected by a
document  subsequently  filed with the SEC. The financial  statements of Parent,
including  the  notes  thereto,  included  in the  SEC  Documents  (the  "Parent
Financial  Statements")  comply  as  to  form  in  all  material  respects  with
applicable accounting  requirements and with the published rules and regulations
of the SEC with respect  thereto,  have been  prepared in  accordance  with GAAP
consistently applied (except as may be indicated in the notes thereto or, in the
case of unaudited statements,  as permitted by Form 10-Q of the SEC) and present
fairly the  consolidated  financial  position of Parent at the dates thereof and
the  consolidated  results of its operations and cash flows for the periods then
ended  (subject,  in  the  case  of  unaudited   statements,   to  normal  audit
adjustments).  There has been no change in Parent accounting  policies except as
described in the notes to the Parent Financial  Statements;  provided,  however,
the Parent may have restated or may restate one or more of the Parent  Financial
Statements to reflect  acquisitions  entered into  subsequent to the  respective
dates thereof.

         III.5 Litigation  There is no action, suit,  proceeding,  claim,  
arbitration  or  investigation  pending,  or as to which Parent has received any
notice of assertion  against Parent,  which in any manner challenges or seeks to
prevent, enjoin, alter or materially delay any of the transactions  contemplated
by this Agreement.  Parent is not subject to any material  litigation  except as
disclosed in the SEC Documents.


                                   ARTICLE IV

                       CONDUCT PRIOR TO THE EFFECTIVE TIME

         IV.1     Conduct of Business of the Company.






                  (a Company  Conduct.  During the period  from the date of this
Agreement and continuing  until the earlier of the termination of this Agreement
or the  Effective  Time,  the Company  agrees  (except to the extent that Parent
shall  otherwise  consent in  writing)  to carry on its  business  in the usual,
regular and  ordinary  course in  substantially  the same  manner as  heretofore
conducted,  to pay its  debts  and  Taxes  when  due,  to pay or  perform  other
obligations when due, and, to the extent  consistent with such business,  to use
all reasonable  efforts  consistent  with past practice and policies to preserve
intact its present  business  organization,  keep  available the services of its
present  officers  and key  employees  and  preserve  their  relationships  with
customers, suppliers, corporate partners,  collaborators,  licensors, licensees,
and others  having  business  dealings  with it, all with the goal of preserving
unimpaired  its goodwill  and ongoing  businesses  at the  Effective  Time.  The
Company shall promptly notify Parent of any event or occurrence or emergency not
in the ordinary  course of its  business,  and any material  event  involving or
adversely   affecting  the  Company  or  its   business.   Except  as  expressly
contemplated by this Agreement, the Company shall not, without the prior written
consent of Parent:

                           (i       Enter into any commitment, activity or 
transaction not in the ordinary course of business;

                           (ii      Transfer to any person or entity any rights
to any Company IntellectualProperty Rights;

                           (iii     Enter into or amend any material agreements
pursuant  to  which  any  other  party  is  granted  manufacturing,   marketing,
distribution, licensing or similar rights of any type or scope;

                           (iv      Amend or otherwise modify (or agree to do
so), except in the ordinary course of business,  or violate the terms of, any of
the material  agreements to which the Company is a party, or enter into material
capital commitments or material long term obligations;

                           (v       Commence or settle any litigation;

                           (vi      Declare, set aside or pay any dividends on 
or make any other distributions  (whether in cash, stock or property) in respect
of any of its capital stock, or split,  combine or reclassify any of its capital
stock or issue or authorize the issuance of any other  securities in respect of,
in lieu of or in  substitution  for shares of capital  stock of the Company,  or
repurchase,  redeem or otherwise acquire, directly or indirectly,  any shares of
its capital stock (or options, warrants or other rights exercisable therefor);

                           (vii     Except for the issuance of shares of Company
Capital  Stock upon  exercise or  conversion  of presently  outstanding  Company
Options,  issue,  grant,  deliver or sell or authorize or propose the  issuance,
grant,  delivery or sale of, or purchase or propose the  purchase of, any shares
of its capital stock or securities  convertible into, or subscriptions,  rights,
warrants  or options to  acquire,  or other  agreements  or  commitments  of any
character   obligating  it  to  issue  any  such  shares  or  other  convertible
securities;

                           (viii    Cause or permit any amendments to its 
Articles of Incorporation or Bylaws;






                           (ix      Acquire or agree to acquire by merging or
consolidating  with, or by purchasing any assets or equity  securities of, or by
any other manner, any business or any corporation,  partnership,  association or
other business  organization or division thereof,  or otherwise acquire or agree
to acquire any assets which are material,  individually or in the aggregate,  to
the business of the Company;

                           (x       Purchase, sell, lease, license or otherwise
dispose of any properties or assets,  except in the ordinary  course of business
and consistent with past practice;

                           (xi      Incur any indebtedness for borrowed money or
guarantee  any such  indebtedness  or issue or sell any debt  securities  of the
Company or guarantee any debt securities of others;

                           (xii     Grant any severance or termination pay to 
any director,  officer employee or consultant,  except payments made pursuant to
standard  written  agreements   outstanding  on  the  date  hereof  (which  such
agreements are disclosed on Schedule 2.12(a);

                           (xiii Adopt or amend any employee benefit, bonus, or 
severance plan,  program,  policy or  arrangement,  or enter into any employment
contract,  extend any employment offer, pay or agree to pay any special bonus or
special  remuneration  to any  director,  officer,  employee or  consultant,  or
increase the  salaries or wage rates of its  directors,  officers,  employees or
consultants;

                           (xiv     Revalue any of its assets, including without
limitation  writing down the value of inventory or writing off notes or accounts
receivable  other than in the ordinary  course of business and  consistent  with
past practice;

                           (xv      Take any action which would, to the
knowledge of the Company, jeopardize the tax-free reorganization hereunder;

                           (xvi     Pay, discharge or satisfy, in an amount in 
excess of $5,000, in any one case, or $10,000 in the aggregate (of like cases or
similar items), any claim, liability or obligation (absolute,  accrued, asserted
or unasserted,  contingent or otherwise),  other than the payment,  discharge or
satisfaction  in the  ordinary  course of business of  liabilities  reflected or
reserved against in the Company Financial Statements;

                           (xvii Make or change any material election in respect
of Taxes,  adopt or change any accounting method in respect of Taxes, enter into
any closing  agreement,  settle any claim or assessment in respect of Taxes,  or
consent to any extension or waiver of the  limitation  period  applicable to any
claim or assessment in respect of Taxes;

                           (xviii  Enter into any strategic alliance, research
collaboration, joint development or joint marketing arrangement or agreement;






                           (xix     Fail to pay or otherwise satisfy its 
monetary  obligations as they become due,  except such as are being contested in
good faith;

                           (xx Waive or commit to waive any rights with a value
in excess of $5,000, in any one case, or $10,000, in the aggregate;

                           (xxi Cancel, materially amend or renew any insurance
policy other than in the ordinary course of business;

                           (xxii Alter, or enter into any commitment to alter, 
its interest in any  corporation,  association,  joint  venture,  partnership or
business entity in which the Company  directly or indirectly  holds any interest
on the date hereof; or

                           (xxiii Take, or agree in writing or otherwise to
take, any of the actions  described in Sections  4.1(i) through (xxii) above, or
any other  action that would  prevent the Company from  performing  or cause the
Company not to perform its covenants hereunder.

                  (b Parent Conduct. Parent shall promptly notify the Company of
any event or  occurrence  which is not in the  ordinary  course of  business  of
Parent and which is  material  and  adverse to the  business  of Parent.  Parent
agrees to disclose  to the  Company  prior to the  Effective  Time any  material
change in its capitalization as set forth in Section 3.3 hereto.






         IV.2 No Solicitation. Until the earlier of the  Effective  Time and the
date of termination of this Agreement  pursuant to the provisions of Section 8.1
hereof,  the Company will not (nor will the Company  permit any of the Company's
officers,  directors,  stockholders,  agents,  representatives or affiliates to)
directly or indirectly,  take any of the following  actions with any party other
than Parent and its designees:  (a) solicit,  initiate,  entertain, or encourage
any  proposals  or  offers  from,  or  conduct  discussions  with or  engage  in
negotiations  with,  any person  relating  to any  possible  acquisition  of the
Company (whether by way of merger, purchase of capital stock, purchase of assets
or otherwise), any material portion of its capital stock or assets or any equity
interest in the  Company,  (b)  provide  information  with  respect to it to any
person, other than Parent,  relating to, or otherwise cooperate with, facilitate
or  encourage  any  effort or  attempt by any such  person  with  regard to, any
possible  acquisition  of the  Company  (whether  by way of merger,  purchase of
capital  stock,  purchase of assets or otherwise),  any material  portion of its
capital stock or assets or any equity interest in the Company, (c) enter into an
agreement with any person,  other than Parent,  providing for the acquisition of
the Company  (whether by way of merger,  purchase of capital stock,  purchase of
assets or otherwise), any material portion of its capital stock or assets or any
equity  interest  in the  Company,  or (d)  make  or  authorize  any  statement,
recommendation  or  solicitation  in support of any possible  acquisition of the
Company (whether by way of merger, purchase of capital stock, purchase of assets
or otherwise), any material portion of its capital stock or assets or any equity
interest in the Company by any person,  other than by Parent.  The Company shall
immediately  cease and cause to be terminated any such contacts or  negotiations
with third parties relating to any such transaction or proposed transaction.  In
addition to the foregoing,  if the Company  receives prior to the Effective Time
or the  termination of this  Agreement any offer or proposal  relating to any of
the above,  the Company  shall  immediately  notify  Parent  thereof,  including
information as to the identity of the offeror or the party making any such offer
or proposal  and the specific  terms of such offer or proposal,  as the case may
be, and such other information related thereto as Parent may reasonably request.
Except as contemplated by this Agreement, disclosure by the Company of the terms
hereof  (other than the  prohibition  of this  section)  shall be deemed to be a
violation of this Section 4.2.


                                    ARTICLE V

                              ADDITIONAL AGREEMENTS

         V.1 Company Stockholder  Approva. As promptly as practicable after the 
execution of this Agreement and at such time as is permitted by applicable  law,
the Company shall submit this Agreement and the transactions contemplated hereby
to its  stockholders for approval and adoption as provided by Oregon Law and its
Articles of Incorporation and Bylaws.  The Company shall use its best efforts to
solicit and obtain the  consent of its  stockholders  sufficient  to approve the
Merger and this  Agreement  and to enable the  Closing to occur as  promptly  as
practicable.  The  materials  submitted to the Company's  stockholders  shall be
subject to review and approval by Parent and include  information  regarding the
Company,  the  terms  of  the  Merger  and  this  Agreement  and  the  unanimous
recommendation  of the Board of  Directors of the Company in favor of the Merger
and this Agreement.

         V.2  Access  to  Information.   Access to Information.  The Company 
shall  afford  Parent and its  accountants,  counsel and other  representatives,
reasonable  access during normal  business  hours during the period prior to the
Effective Time to: (a) all of its properties, books, contracts,  commitments and
records, and (b) all other information  concerning the business,  properties and
personnel  (subject to  restrictions  imposed by applicable law) of it as Parent
may  reasonably   request.   No   information  or  knowledge   obtained  in  any
investigation  pursuant to this  Section 5.2 shall affect or be deemed to modify
any  representation  or  warranty  contained  herein  or the  conditions  to the
obligations of the parties to consummate the Merger.






         V.3 Confidentiality.  Subject to Section 5.5 hereof,  the parties agree
that neither  they nor their  agents  shall  disclose to any person who is not a
direct  participant in the negotiations or due diligence  regarding the proposed
transactions  any of the terms or  conditions of the proposed  transactions.  In
addition,  each  party  will  maintain  in strict  confidence  all  confidential
information  ("Confidential  Information")  obtained from any other party or its
agents  during the course of the due  diligence  and  negotiation.  Confidential
Information  means  nonpublic  information  concerning  the  disclosing  party's
business,  business plans,  products or technology,  whether disclosed before or
after the date of this  Agreement,  which is  clearly  marked  "confidential  or
"proprietary"  and  orally  disclosed  information  which is  communicated  with
indicia of confidentiality  and promptly  thereafter  confirmed in writing to be
confidential.  Confidential  Information  shall not include any  information  in
writing which is or becomes  publicly  known or available  not through  improper
action of the receiving  party, is already known by the receiving party prior to
disclosure,  is  independently  developed by the  receiving  party without using
Confidential  Information  of the other party,  or is obtained by the  receiving
party from a third party without breach of a confidentiality  obligation. In the
event that the transaction is not  consummated,  or any time upon the request of
any party, all material furnished by such party or its agents to any other party
or its agents, and all copies or extracts thereof in notes and analyses prepared
therefrom,  shall be returned to the disclosing party or destroyed and certified
as destroyed.

         V.4  Expenses.  Whether  or not the Merger is consummated,  all fees 
and  expenses  incurred  in  connection  with  the  Merger  including,   without
limitation, all legal, accounting,  financial advisory, consulting and all other
fees and expenses of third parties ("Third Party Expenses")  incurred by a party
in connection with the negotiation and  effectuation of the terms and conditions
of this  Agreement  and  the  transactions  contemplated  hereby,  shall  be the
obligation of the respective  party incurring such fees and expenses;  provided,
however,  that  expenses  payable to legal  counsel to the Company in connection
with the Merger shall not be paid by the Company or Parent but instead  shall be
borne pro rata among the holders of the  Company's  Common  Stock and  Company's
Options on an as-converted basis to the extent that such legal fees and expenses
exceed [***].

         V.5 Public Disclosure. Unless otherwise  required by law  (including,  
without limitation,  federal and state securities laws) or, as to Parent, by the
rules and regulations of the National  Association of Securities Dealers,  Inc.,
prior to the Effective Time, no further  disclosure  (whether or not in response
to an inquiry) of the terms of this Agreement  shall be made by any party hereto
except as contemplated  herein,  unless approved by Parent and the Company prior
to release, provided that such approval shall not be unreasonably withheld.

         V.6 Consents.  The Company shall use its best efforts to obtain the
consents, waivers and approvals under any of the Contracts as may be required in
connection with the Merger (all of such consents,  waivers and approvals are set
forth in Company  Schedules) so as to preserve all rights of and benefits to the
Company thereunder.

         V.7 FIRPTA Compliance.  On or prior to the  Closing  Date, the  Company
shall  deliver  to Parent a properly  executed  statement  in a form  reasonably
acceptable  to Parent for  purposes of  satisfying  Parent's  obligations  under
Treasury Regulation Section 1.1445-2(c)(3).






         V.8 Reasonable  Efforts.   Subject to the terms and conditions provided
in this Agreement,  each of the parties hereto shall use its reasonable  efforts
to ensure that its representations and warranties remain true and correct in all
material respects,  and to take promptly, or cause to be taken, all actions, and
to do promptly,  or cause to be done, all things necessary,  proper or advisable
under  applicable  laws and  regulations  to consummate  and make  effective the
transactions  contemplated hereby, to obtain all necessary waivers, consents and
approvals,  to effect all necessary registrations and filings, and to remove any
injunctions  or other  impediments  or delays,  legal or otherwise,  in order to
consummate and make effective the  transactions  contemplated  by this Agreement
for the purpose of securing to the parties hereto the benefits  contemplated  by
this  Agreement;  provided  that  Parent  shall not be  required to agree to any
divestiture  by  Parent  or  the  Company  or any of  Parent's  subsidiaries  or
affiliates of shares of capital stock or of any business,  assets or property of
Parent or its  subsidiaries or affiliates or the Company or its  affiliates,  or
the  imposition  of any  material  limitation  on the  ability of any of them to
conduct  their  businesses  or to  own  or  exercise  control  of  such  assets,
properties and stock.

         V.9  Notification  of  Certain   Matters. The Company shall give prompt
notice to Parent, and Parent shall give prompt notice to the Company, of (i) the
occurrence or  non-occurrence  of any event, the occurrence or non-occurrence of
which is likely to cause any  representation  or  warranty  of the  Company  and
Parent, respectively,  contained in this Agreement to be untrue or inaccurate at
or prior to the Effective Time and (ii) any failure of the Company or Parent, as
the case may be, to comply with or satisfy any covenant,  condition or agreement
to be complied with or satisfied by it hereunder;  provided,  however,  that the
delivery of any notice pursuant to this Section 5.9 shall not limit or otherwise
affect any remedies available to the party receiving such notice.

         V.10  Affiliate   Agreements.  Schedule  5.10 sets  forth  those  
persons who, in the Company's reasonable judgment, are or may be "affiliates" of
the Company  within the  meaning of Rule 145 (each such  person an  "Affiliate")
promulgated  under the  Securities  Act ("Rule 145").  The Company shall provide
Parent such  information  and documents as Parent shall  reasonably  request for
purposes  of  reviewing  such list.  The  Company  shall  deliver or cause to be
delivered to Parent,  concurrently  with the execution of this Agreement (and in
any case prior to the Closing) from each of the  Affiliates  of the Company,  an
executed  Affiliate  Agreement  in  substantially  the form  attached  hereto as
Exhibit  A.  Parent  shall be  entitled  to  place  appropriate  legends  on the
certificates  evidencing  any  Parent  Common  Stock  to  be  received  by  such
Affiliates  pursuant to the terms of this  Agreement,  and to issue  appropriate
stop  transfer  instructions  to the  transfer  agent for Parent  Common  Stock,
consistent with the terms of such Affiliate Agreements.

         V.11  Additional  Documents  and  Further   Assurances.  
Each party hereto,  at the request of the other party hereto,  shall execute and
deliver such other  instruments and do and perform such other acts and things as
may be necessary or desirable for effecting  completely the consummation of this
Agreement and the transactions contemplated hereby.

         V.12  Nasdaq  National  Market   Listing.  Parent shall authorize for
listing  on the  Nasdaq  National  Market  the  shares  of Parent  Common  Stock
issuable, and those required to be reserved for issuance, in connection with the
Merger, upon official notice of issuance.

         V.13   Company's   Financial    Statements. The Company will  use  best
reasonable  efforts to facilitate on a timely basis the preparation of financial
statements as required by Parent to comply with applicable SEC regulations.






         V.14 Milestone  Warrants. Upon  completion of the following  milestones
(the  "Milestones"),  Parent  shall issue to the persons and in the  proportions
listed on Schedule 5.14 attached hereto  warrants (the "Milestone  Warrants") in
substantially  the form attached  hereto as Exhibit E, provided,  however,  that
with respect to any such person who becomes an employee or  consultant of Parent
or the Surviving  Corporation at or after the Effective  Time,  such person must
still be then  employed  by or  providing  services  to Parent or the  Surviving
Corporation  to be issued any portion of such  Milestone  Warrant.  In the event
that any such person is no longer employed by or providing services to Parent or
the Surviving  Corporation,  such person's  allocation of the Milestone Warrants
shall be allocated to the other  persons  listed on Schedule  5.14 on a pro rata
basis.  The Milestone  Warrants shall entitle the holders thereof to purchase an
aggregate of the number of shares of Common Stock of Parent set forth below at a
per share  exercise price equal to the average of the closing prices of Parent's
Common Stock on the principal securities exchange on which Parent's Common Stock
is then traded, or if not so traded,  the National Market System of the National
Association of Securities Dealers Automated  Quotation System, in either case as
reported in The Wall Street Journal, for the fifteen (15) trading days ending on
the last trading day prior to the date which such  Milestone is  completed.  The
Milestone Warrants shall have a term of ten (10) years from the date of Closing,
provided, however, that: (1) in event of the closing of an acquisition of all of
the  outstanding  capital  stock or all or  substantially  all of the  assets of
Parent or any other  event set forth in  Section  10 of the  Milestone  Warrant,
Parent's right to repurchase  shares issued upon exercise of Milestone  Warrants
shall  lapse,  and (2) in  event of the  closing  of an  acquisition  of all the
outstanding  capital stock or all or substantially  all of the assets of Parent,
the acquiring  party shall be required to assume any obligations of Parent under
this Section 5.14 with respect to unissued  Milestone  Warrants.  The holders of
the  Milestone  Warrants  shall  be  included  in  Parent's  existing  piggyback
registration rights, provided that the requisite consent of the other holders of
registrable  securities  of Parent  can be  obtained.  Parent  agrees to use its
reasonable efforts to obtain such consent.

                  (a       Milestone Warrant One.  An aggregate of 50,000 shares
(as adjusted for stock splits, stock dividends, recapitalizations, and the like)
for [***].

                  (b       Milestone Warrant Two.  An aggregate of 50,000 shares
(as adjusted for stock splits, stock dividends, recapitalizations, and the like)
if within [***].






         V.15 Oregon Health Sciences  University  Laboratory  Funding.  
Parent shall  provide  funding to Dr. Roger Cone's  research  laboratory  at the
Oregon Health Sciences  University in the amount [***] commencing on the Closing
Date;  provided,  however,  that Parent's  obligation to make or continue making
funding  payments shall be expressly  contingent upon: (1) the continuous use of
such funding in accordance  with the Research Plan agreed upon by Parent and Dr.
Roger Cone substantially in the form attached hereto as Exhibit F (as Parent and
Dr. Cone may mutually agree to modify such Research Plan),  and (2) the grant by
the Oregon Health Sciences University of rights reasonably  acceptable to Parent
with regard to the intellectual  property resulting from such research.  Funding
shall be due and payable in equal  quarterly  installments  within  fifteen (15)
days after the end of each of Parent's fiscal quarters.

         V.16     Name and Physical Location of the Surviving Corporation.  
[***] Dr.  Roger Cone (who shall be referred to as "Company  Management")  shall
mutually agree to do so.

         V.17     [***].

         V.18     Employment and Consulting Arrangements.

                  (a All Company  employees  who  continue as  employees  of the
Surviving Corporation after the Closing shall be entitled to benefits comparable
to the  benefits  Parent  provides  its  employees  at the  same  level  as such
employees of the Surviving Corporation will be after the Closing.

                  (b       Steve Kurtz.  The Company shall enter into an 
employment   agreement   (the   "Employment   Agreement")   with  Stephen  Kurtz
substantially in the form attached hereto as Exhibit B.

                  (c       Paul Woloshin.  As soon as practicable after the
execution of this  Agreement,  the Company and Paul  Woloshin  will enter into a
consulting  agreement with a [***] term, whereby:  (i) the Company shall pay Mr.
Woloshin an annual fee of [***].  The parties  shall  negotiate in good faith to
reach a definitive agreement with regard to the aforementioned arrangement.






         V.19 Appointment to Parent Scientific Advisory BoardV.19 Appointment to
Parent Scientific  Advisory BoardV.19  Appointment to Parent Scientific Advisory
Board.  Parent  shall  appoint  Dr.  Roger Cone and Dr.  Susan Amara to Parent's
Scientific  Advisory  Board  substantially  in  accordance  with the  Consulting
Agreements attached hereto as Exhibit G-1 and G-2, respectively.

         V.20     [***].

         V.21  Registration  on  Form  S-8V.21   Registration  on  Form  S-8V.21
Registration  on Form S-8.  Parent shall,  as soon as practicable  following the
Effective  Time,  register  the  shares of Parent  Common  Stock  issuable  upon
exercise of the Parent Options on a registration statement on Form S-8.
  

         VI.1  Conditions to  Obligations of Each Party to Effect the MergerVI.1
Conditions to Obligations  of Each Party to Effect the MergerVI.1  Conditions to
Obligations of Each Party to Effect the Merger.
         The  respective  obligations  of each party to this Agreement to effect
the Merger  shall be subject to the  satisfaction  at or prior to the Closing of
the following conditions:

                  (a       Stockholder Approval.  This Agreement and the Merger
shall have been approved and adopted by the  stockholders  of the Company by the
requisite vote under applicable law and the Company's Articles of Incorporation.

                  (b  Securities  Law  Compliance.  The  issuance  of the Parent
Common Stock in the Merger shall be exempt from the registration  requirement of
the federal  securities  laws and shall have been  qualified  or shall be exempt
under all applicable state securities laws.

                  (c No  Injunctions  or  Restraints;  Illegality.  No temporary
restraining order,  preliminary or permanent injunction or other order issued by
any court of competent  jurisdiction  or other legal or regulatory  restraint or
prohibition preventing the consummation of the Merger shall be in effect.

                  (d       Consulting and Noncompetition Agreements.  Dr. Susan 
Amara and Dr.  Roger Cone shall each have  executed  and  delivered  to Parent a
Consulting  Agreement  in  substantially  the  form  of  Exhibit  G-1  and  G-2,
respectively, and such agreements shall be in full force and effect.

                  (e       Registration Rights Agreement.  Parent and certain of
the Company's  stockholders shall have executed a Registration  Rights Agreement
in substantially the form of Exhibit J and such agreement shall be in full force
and effect.






         VI.2 Additional Conditions to Obligations of the Company.  
The  obligations  of the Company to consummate  the Merger and the  transactions
contemplated by this Agreement shall be subject to the  satisfaction at or prior
to the Closing of each of the following conditions,  any of which may be waived,
in writing, exclusively by the Company:

                  (a Representations  and Warranties.  The  representations  and
warranties  of Parent and Merger Sub contained in this  Agreement  shall be true
and correct in all material  respects on and as of the Closing Date,  except for
changes contemplated by this Agreement and except for those  representations and
warranties  which  address  matters  only as of a  particular  date (which shall
remain true and  correct as of such date),  with the same force and effect as if
made on and as of the  Closing  Date  and the  Company  shall  have  received  a
certificate  to such  effect  signed by duly  authorized  officers of Parent and
Merger Sub.

                  (b Agreements and Covenants.  Parent and Merger Sub shall have
performed or complied in all material respects with all agreements and covenants
required by this  Agreement to be performed or complied with by them on or prior
to the Effective Time, and the Company shall have received a certificate to such
effect signed by duly authorized officers of Parent and Merger Sub.

         VI.3  Additional  Conditions  to the  Obligations  of Parent and Merger
SubVI.3  Additional  Conditions to the Obligations of Parent and Merger Sub. The
obligations  of  Parent  and  Merger  Sub  to  consummate  the  Merger  and  the
transactions contemplated by this Agreement shall be subject to the satisfaction
at or prior to the Closing of each of the following conditions, any of which may
be waived, in writing, exclusively by Parent:

                  (a Representations  and Warranties.  The  representations  and
warranties of the Company  contained in this Agreement shall be true and correct
in all respects on and as of the Closing Date,  except for changes  contemplated
by this  Agreement and except for those  representations  and  warranties  which
address  matters  only as of a  particular  date  (which  shall  remain true and
correct as of such date), with the same force and effect as if made on and as of
the Closing Date; and Parent and Merger Sub shall have received a certificate to
such  effect  signed on behalf of the  Company  by a duly  authorized  executive
officer of the Company;

                  (b Agreements and Covenants.  The Company shall have performed
or complied in all respects with all agreements  and covenants  required by this
Agreement to be performed  or complied  with by it on or prior to the  Effective
Time, and Parent and Merger Sub shall have received a certificate to such effect
signed by a duly authorized officer of the Company;

                  (c       Third Party Consents.  Parent shall have been 
furnished  with  evidence  satisfactory  to it that the Company has obtained all
necessary   consents,   approvals  and  waivers  in  order  to  consummate   the
transactions contemplated herein.

                  (d       Legal Opinion.  Parent shall have received a legal
opinion from Tonkon Torp LLP, legal counsel to the Company, in substantially the
form attached hereto as Exhibit D.






                  (e Affiliate Agreements.  All directors,  officers and persons
identified  by the  Company  as being an  Affiliate  of the  Company  shall have
delivered to Parent an executed Affiliate  Agreement,  in substantially the form
attached hereto as Exhibit A, which shall be in full force and effect.

                  (f       No Material Adverse Change.  There shall not have 
occurred  any  material  adverse  change  in  the  business,  assets  (including
intangible  assets) financial  condition or results of operations of the Company
since January 1, 1998.

                  (g       Vote of Company Stockholders.  Holders of at least 
95% of the  outstanding  Company  Capital Stock shall have voted in favor of the
Merger and the consummation of the transactions contemplated hereby.

                  (h Lockup  Agreements.  The persons listed on Schedule  1.9(a)
shall each have executed a Lockup Agreement  substantially in the form set forth
on Exhibit C-2 and all other persons who receive Parent Common Stock pursuant to
Section 1.6(a) hereof shall each have executed a Lockup Agreement  substantially
in the form set forth on Exhibit C-1.

                  (i       Valid Existence Certificate.  The Company shall have
delivered to counsel for Parent a certificate  evidencing  the  Company's  valid
existence under Oregon Law.

                  (j       Financial Statements Certificate.  The Company shall 
have delivered to Parent a certificate  signed by Paul Woloshin attesting to the
best of his knowledge as to the accuracy of the Company's  Financials  delivered
pursuant to Section 2.5 hereof.

                  (k       Escrow Agreement.  Parent, the Escrow Agent and the
stockholders   of  the  Company  shall  have   executed  the  Escrow   Agreement
substantially in the form attached hereto as Exhibit I.

                  (l Stock  Restriction  Agreements.  Each of the  employees and
consultants  listed on Schedule  1.9(a) shall have  executed  Stock  Restriction
Agreements  with  respect to the shares of Parent  Common  Stock  issued to such
persons  hereunder  or  issuable to such  persons  upon  exercise  of  Milestone
Warrants  substantially  in the  form  attached  hereto  as  Exhibit  K and such
agreements shall be in full force and effect.

                  (m Option  Amendments.  Each of the holders of Company Options
shall have executed an Amendment to Stock Option  Agreement  (providing  for the
application  of the  vesting  schedule  set forth in  Section  1.9 hereof to the
Parent Options) substantially in the form attached hereto as Exhibit L.






                  (n Resignations of Company  Officers/Directors.  The Company's
officers and directors  shall have  delivered to Parent's  counsel  resignations
effective as of the Effective Time and taken all steps  reasonably  necessary to
ensure that the officers and  directors  referred to in Section 1.5 hereof shall
be the officers and directors of the Surviving Corporation.

                  (o  Non-Competition  Agreement.  The Company and Paul Woloshin
shall have executed a  non-competition  agreement whereby Mr. Woloshin shall not
compete  with the Company in the fields of  neurotransporters  and  melanocortin
receptors for a period of [***] after the Effective Time,  substantially  in the
form attached hereto as Exhibit M.


                                   ARTICLE VII

               SURVIVAL OF REPRESENTATIONS AND WARRANTIES; ESCROW

         VII.1  Survival  of  Representations  and  WarrantiesVII.1  Survival of
Representations  and  Warranties.  All  of  the  Company's  representations  and
warranties in this  Agreement or in any  instrument  delivered  pursuant to this
Agreement (each as modified by the Company  Schedules)  shall survive the Merger
and  continue  until  5:00  p.m.,  Pacific  Time,  on the date which is one year
following the date of Closing of this Agreement (the "Expiration Date").

         VII.2 Escrow  ArrangementsVII.2  Escrow Arrangements.  The parties will
enter into an Escrow  Agreement in  substantially  the form  attached  hereto as
Exhibit I.


                                  ARTICLE VIII

                        TERMINATION, AMENDMENT AND WAIVER

         VIII.1 Termination. Except as provided in Section 8.2 below,  this 
Agreement  may be terminated  and the Merger  abandoned at any time prior to the
Effective Time:

                  (a       by mutual consent of the Company and Parent;

                  (b by Parent or the Company if: (i) the Effective Time has not
occurred  before 5:00 p.m.  (Pacific  time) on June 30, 1998  (provided that the
right to  terminate  this  Agreement  under this clause  8.1(b)(i)  shall not be
available to any party whose willful failure to fulfill any obligation hereunder
has been the cause of, or  resulted  in, the  failure of the  Effective  Time to
occur on or before such date); (ii) there shall be a final  nonappealable  order
of a federal or state court in effect preventing  consummation of the Merger; or
(iii) there shall be any statute, rule, regulation or order enacted, promulgated
or issued or deemed  applicable  to the Merger by any  governmental  entity that
would make consummation of the Merger illegal;






                  (c by  Parent  if there  shall  be any  action  taken,  or any
statute,  rule,  regulation or order  enacted,  promulgated  or issued or deemed
applicable to the Merger, by any Governmental  Entity, which would: (i) prohibit
Parent's or the  Company's  ownership  or operation of all or any portion of the
business of the  Company or (ii)  compel  Parent or the Company to dispose of or
hold  separate  all or a portion  of the  business  or assets of the  Company or
Parent as a result of the Merger;

                  (d  by  Parent  if  it  is  not  in  material  breach  of  its
obligations   under  this   Agreement  and  there  has  been  a  breach  of  any
representation,  warranty,  covenant or agreement contained in this Agreement on
the part of the Company  and (i) such breach has not been cured  within ten (10)
business days after written notice to the Company (provided that, no cure period
shall be required for a breach which by its nature cannot be cured), and (ii) as
a result of such breach the conditions set forth in Section 6.3(a) or 6.3(b), as
the case may be, would not then be satisfied;

                  (e by  the  Company  if it is not in  material  breach  of its
obligations   under  this   Agreement  and  there  has  been  a  breach  of  any
representation,  warranty,  covenant or agreement contained in this Agreement on
the part of Parent or Merger Sub and (i) such  breach has not been cured  within
ten (10) business days after written  notice to Parent  (provided  that, no cure
period shall be required for a breach which by its nature cannot be cured),  and
(ii) as a result of such breach the  conditions  set forth in Section  6.2(a) or
6.2(b), as the case may be, would not then be satisfied; or

                  (f by Parent if more than five percent (5%) of the outstanding
shares of Company Common Stock shall be qualified to be Dissenting  Shares after
the first  meeting of or action by the  Company's  stockholders  to approve this
Agreement and the Merger.

Where action is taken to terminate this Agreement  pursuant to this Section 8.1,
it  shall be  sufficient  for  such  action  to be  authorized  by the  Board of
Directors (as applicable) of the party taking such action.

         VIII.2 Effect of Termination.  In the event of  termination  of this 
Agreement as provided in Section 8.1, this Agreement shall forthwith become void
and there shall be no liability or obligation on the part of Parent,  Merger Sub
or the  Company,  or  their  respective  officers,  directors  or  stockholders,
provided that each party shall remain liable for any breaches of this  Agreement
prior to its  termination;  and provided further that the provisions of Sections
5.3 and 5.4 and Article  VIII of this  Agreement  shall remain in full force and
effect and survive any termination of this Agreement.

         VIII.3 Termination Fee. If the Board of Directors of the  Company  does
not unanimously  recommend approval by the Company's  stockholders of the Merger
and this  Agreement and this  Agreement is terminated by the Parent  pursuant to
Section 8.1(f),  then the Company shall pay to Parent, in cash, within three (3)
business  days  after such  termination,  a  nonrefundable  fee in the amount of
$100,000.






         VIII.4 Amendment. This Agreement may not be amended at any time, except
by an instrument in writing signed on behalf of each party hereto, provided that
after this  Agreement has been adopted by the  stockholders  of the Company,  no
such amendment shall reduce the amount or change the form of consideration to be
paid to the  stockholders of the Company  pursuant to this Agreement or alter or
change any of the terms or  conditions of this  Agreement if such  alteration or
change would adversely affect the stockholders of the Company.

         VIII.5 Extension;  Waiver. At any time prior to the Effective Time,
Parent and Merger Sub, on the one hand, and the Company,  on the other,  may, to
the extent legally  allowed,  (i) extend the time for the  performance of any of
the  obligations of the other party hereto,  (ii) waive any  inaccuracies in the
representations  and warranties  made to such party  contained  herein or in any
document  delivered  pursuant hereto, and (iii) waive compliance with any of the
agreements or conditions  for the benefit of such party  contained  herein.  Any
agreement on the part of a party hereto to any such extension or waiver shall be
valid only if set forth in an  instrument  in  writing  signed on behalf of such
party.


                                   ARTICLE IX

                               GENERAL PROVISIONS

         IX.1  Notices.   All  notices  and  other  communications hereunder 
shall be in writing  and shall be deemed  given if  delivered  personally  or by
commercial  delivery service,  or mailed by registered or certified mail (return
receipt  requested)  or sent via  facsimile  (with  acknowledgment  of  complete
transmission)  to the  parties  at the  following  addresses  (or at such  other
address for a party as shall be specified by like notice):

                  (i)      if to Parent or Merger Sub, to:

                           Neurocrine Biosciences, Inc.
                           3050 Science Park Road
                           San Diego, CA 92121
                           Attention:  President and Chief Executive Officer
                           Telephone No.:  (619) 658-7650
                           Facsimile No.:  (619) 658-7602

                           with a copy to:

                           Wilson Sonsini Goodrich & Rosati, P.C.
                           650 Page Mill Road
                           Palo Alto, California 94304
                           Attention:  Michael J. O'Donnell, Esq.
                           Telephone No.:  (415) 493-9300
                           Facsimile No.:  (415) 493-6811






                  (ii)     if to the Company, to:

                           Northwest NeuroLogic, Inc.
                           2611 S.W. 3rd Avenue, Suite 200
                           Portland, OR  97201
                           Attention:  President
                           Telephone No.:  (503) 243-6422
                           Facsimile No.:  (503) 228-3290

                           with a copy to:

                           Tonkon Torp LLP
                           1600 Pioneer Tower
                           888 SW Fifth Avenue
                           Portland, OR  97204
                           Attention:  Carol Dey Hibbs
                           Telephone No.:  (503) 802-2016
                           Facsimile No.:  (503) 972-3716

         IX.2 Interpretation. The words "include," "includes" and "including"  
when  used  herein  shall be deemed  in each  case to be  followed  by the words
"without  limitation."  The table of contents  and  headings  contained  in this
Agreement  are for  reference  purposes only and shall not affect in any way the
meaning or interpretation of this Agreement.

         IX.3 Counterparts.  This Agreement may be executed in one or more  
counterparts,  all of which shall be considered  one and the same  agreement and
shall become effective when one or more counterparts have been signed by each of
the parties and  delivered  to the other  party,  it being  understood  that all
parties need not sign the same counterpart.

         IX.4 Entire Agreement;  Assignment.  This  Agreement,  the  Schedules 
and Exhibits  hereto,  and the documents and  instruments  and other  agreements
among the parties hereto referenced  herein: (a) constitute the entire agreement
among the parties with respect to the subject  matter  hereof and  supersede all
prior  agreements and  understandings,  both written and oral, among the parties
with respect to the subject matter  hereof;  (b) are not intended to confer upon
any other person any rights or remedies hereunder; and (c) shall not be assigned
by  operation of law or otherwise  except as  otherwise  specifically  provided,
except  that  Parent  and  Merger Sub may  assign  their  respective  rights and
delegate their respective obligations hereunder to their respective affiliates.






         IX.5 Severability. In the event that any provision of this Agreement or
the  application  thereof,  becomes  or is  declared  by a  court  of  competent
jurisdiction  to be  illegal,  void  or  unenforceable,  the  remainder  of this
Agreement  will  continue in full force and effect and the  application  of such
provision to other persons or circumstances will be interpreted so as reasonably
to effect the intent of the parties hereto. The parties further agree to replace
such  void or  unenforceable  provision  of  this  Agreement  with a  valid  and
enforceable  provision that will achieve, to the extent possible,  the economic,
business and other purposes of such void or unenforceable provision.

         IX.6 Other  Remedies.  Except as otherwise provided herein,  any and 
all remedies herein expressly  conferred upon a party will be deemed  cumulative
with and not exclusive of any other remedy conferred hereby, or by law or equity
upon such party, and the exercise by a party of any one remedy will not preclude
the exercise of any other remedy.

IX.7  Governing  Law.  This  Agreement  shall be  governed by and  construed  in
accordance with the laws of the State of California, regardless of the laws that
might otherwise govern under applicable principles of conflicts of laws thereof.
Each of the parties  hereto  agrees that  process may be served upon them in any
manner  authorized by the laws of the State of  California  for such persons and
waives  and  covenants  not to assert or plead any  objection  which  they might
otherwise have to such jurisdiction and such process.

IX.8  Rules of  Construction.  The  parties  hereto  agree  that  they have been
represented  by counsel during the  negotiation  and execution of this Agreement
and, therefore, waive the application of any law, regulation, holding or rule of
construction  providing that  ambiguities in an agreement or other document will
be construed against the party drafting such agreement or document.

IX.9 Specific  Performance.  The parties  hereto agree that  irreparable  damage
would occur in the event that any of the  provisions of this  Agreement were not
performed in accordance with their specific terms or were otherwise breached. It
is  accordingly  agreed that the parties  shall be entitled to an  injunction or
injunctions to prevent  breaches of this  Agreement and to enforce  specifically
the terms and  provisions  hereof in any court of the United States or any state
having  jurisdiction,  this being in addition to any other  remedy to which they
are entitled at law or in equity.


                  [remainder of page intentionally left blank]






         IN WITNESS WHEREOF, Parent, Merger Sub and the Company have caused this
Agreement to be signed by their duly authorized  respective officers,  all as of
the date first written above.

NORTHWEST NEUROLOGIC, INC.           NEUROCRINE BIOSCIENCES, INC.

By: /s/ Roger D. Cone                By: /s/ Paul W. Hawran
        President                            Senior Vice President and
                                             Chief Financial Officer


NBI ACQUISITION CORP.

By:     /s/ Paul W. Hawran
            Senior Vice President and
            Chief Financial Officer









                                INDEX OF EXHIBITS



Exhibit           Description


                                 
Exhibit A                           Form of Company Affiliate Agreement

Exhibit B                           Employment Agreement (Steve Kurtz)

Exhibit C-1                         Form of Lockup Agreement (180-day)

Exhibit C-2                         Form of Lockup Agreement (90-day)

Exhibit D                           Form of Legal Opinion of Counsel to the Company

Exhibit E                           Form of Milestone Warrant

Exhibit F                           Research Plan for Oregon Health Sciences University

Exhibit G-1                         Form of Consulting Agreement (Dr. Roger Cone)

Exhibit G-2                         Form of Consulting Agreement (Dr. Susan Amara)

Exhibit H                           Parent's Insider Trading Policy

Exhibit I                           Escrow Agreement

Exhibit J                           Registration Rights Agreement

Exhibit K                           Form of Stock Restriction Agreement

Exhibit L                           Form of Amendment to Stock Option Agreement

Exhibit M                           Form of Non-Competition Agreement (Paul Woloshin)








                               INDEX OF SCHEDULES



Schedule          Description
                                            
                                                                              
1.6                                 Escrow Amount
1.9(a)                              Employees and Consultants of the Company 
                                     Subject to Vesting Schedules and
                                     Lockup Periods
2.2(a)                              Company Stockholder List
2.2(b)                              Option List
2.4                                 Governmental and Third Party Consents
2.5                                 Company Financials
2.6                                 Undisclosed Liabilities
2.7                                 No Changes
2.8                                 Tax Returns and Audits
2.10(a)                             Leased Real Property
2.10(b)                             Liens on Property
2.11(a)                             Intellectual Property
2.11(b)                             Intellectual Property Licenses
2.11(c)                             Confidentiality Agreements
2.12(a)                             Agreements, Contracts and Commitments
2.12(b)                             Breaches
2.13                                Interested Party Transactions
2.15                                Litigation
2.19                                Brokers/Finders Fees; Third Party Expenses
2.20(b)                             Employee Benefit Plans and Employee 
                                     Agreements
2.20(d)                             Employee Plan Compliance
2.20(g)                             Post Employment Obligations
2.20(h)(i)                          Effect of Transaction
2.20(h)(ii)                         Excess Parachute Payments
2.20(j)                             Labor
5.10                                Company Affiliate List
5.14                                Milestone Warrant Holder List






                                  Schedule 1.6
                                 Escrow Account


The following shares of Parent Common Stock will be placed in the escrow account
or, in the case of  options,  will be subject to the escrow  account and will be
placed in the escrow account upon exercise of the applicable option:


- ------------------------- ------------------ ----------------- ----------------------- -----------------

                           [***] Shares in   [***] Shares in      [***] Options in      [***] Options
          Name                 Escrow             Escrow               Escrow             in Escrow
- ------------------------- ------------------ ----------------- ----------------------- -----------------
                                                                                        
[***]                                [***]             [***]                   [***]             [***]
- ------------------------- ------------------ ----------------- ----------------------- -----------------
Total                                53,088            29,665                   6,839            10,011






                                 Schedule 1.9(a)
               Continuing Employees and Consultants of the Company
                 Subject to Vesting Schedule and Lockup Periods


1.       The  following  people are the  persons  (besides  Roger Cone and Susan
         Amara) who are expected to be employees or  consultants  of the Company
         holding  Company  stock or stock  options  at the  time the  Merger  is
         closed:

         [***]

2.       If any of the  foregoing  persons  is not  employed  by or serving as a
         consultant  to the  Company at the date of  Closing,  we will so advise
         you, and any such  persons will not be subject to the vesting  schedule
         of  Section  1.9 and shall not be deemed to be a person  listed on this
         Schedule 1.9(a).




                                 Schedule 2.2(a)
                            Company Stockholder List



- ---------------------------------------------------------------------------- -----------------------

Stockholder                                                                   Number of Shares of
                                                                                  Common Stock
- ---------------------------------------------------------------------------- -----------------------

                                                                                  
Roger Cone                                                                           [***]
c/o Vollum Institute
3181 S.W. Sam Jackson Park Road
Portland, OR 97201-3098
                                                                                     [***]
Richard Sessions
c/o Vollum Institute
3181 S.W. Sam Jackson Park Road
Portland, OR 97201-3098
                                                                                     [***]
Oregon Health Sciences University
3181 S.W. Sam Jackson Park Road
Portland, OR 97201-3098
                                                                                     [***]
Susan Amara
c/o Vollum  Institute
3181  S.W.  Sam  Jackson  Park  Road
Portland,  OR 97201-3098
                                                                                     [***]
Cascadia Pacific Management
4370 NE Halsey
Portland,  OR 97213
 (assignee of shares originally to be issued to
 Oregon Research and Technology
 Development Fund)
- ---------------------------------------------------------------------------- -----------------------

TOTAL SHARES                                                                          591,250
- ---------------------------------------------------------------------------- -----------------------







                                 Schedule 2.2(b)
                                   Option List


1. The Stock Option  Ledger  attached  hereto as Appendix A is correct as of the
date of this Agreement.

2.       When NNL granted the option to Jeffery Arriza, a Pennsylvania resident,
         as  specified  on the Stock  Option  Ledger,  the filing to qualify the
         option grant for an exemption  under  Pennsylvania  securities  law was
         filed late.






                                  Schedule 2.4
                      Governmental and Third Party Consents


1.       The license agreement between Oregon Health Sciences University and the
         Company,  dated  February 1, 1997,  may arguably  require notice of the
         Merger. That notice has been given.

2.       The Leases  between  the Company  and Oregon  Biotechnology  Innovation
         Center ("OBIC")  require OBIC's consent to the assignment of the Leases
         in the context of the Merger.  That consent  will be obtained  prior to
         Closing.






                                  Schedule 2.5
                               Company Financials


1.       Attached hereto as Appendix B is the Company's  unaudited balance sheet
         as of  December  31,  1997  and  the  related  unaudited  statement  of
         operations for the 12-month period then ended.

2.       In order to be correct in all material respects, the attached Financial
         Statements need to be adjusted to reflect the following:

         a.       The  Company  needs to deduct  from its  earnings  the  spread
                  between the  exercise  price of all  discounted  options  that
                  vested during 1997 and the fair market value of the underlying
                  option shares at the time of vesting.

         b. Accrued vacation is not reflected in the Financial Statements.






                                  Schedule 2.6
                             Undisclosed Liabilities

1.       Paragraph 2 of Schedule 2.5 is incorporated herein by reference.

2.       In 1998,  the Company  will need to deduct from its 1998  earnings  the
         spread between the exercise  price of all discounted  options that vest
         during 1998 and the fair market value of the  underlying  option shares
         at the time of vesting.

3.       Contractual   obligations   (rather  than  liabilities   stemming  from
         breaches)  under  contracts  listed on Schedules  2.10(a),  2.11(b) and
         2.12(a).

4.       The Company has been awarded an NIH grant which will require  specified
         projects be undertaken.  The Company has not received the documentation
         on the grant yet.






                                  Schedule 2.7
                                   No Changes


1.       [***].

2.       Options have been granted since  December 31, 1997, as reflected in the
         Stock Option Ledger attached to Schedule 2.2(b).

3.       The vesting of certain options has been  accelerated in connection with
         this  transaction,  as shown on the Stock  Option  ledger  attached  to
         Schedule 2.2(b).

4.       Kimberlee  Stafford and Elizabeth  Fiddler received salary increases of
         $5,000 per year, effective January 1, 1998.

5.       [***].






                                  Schedule 2.8
                             Tax Returns and Audits


None






                                Schedule 2.10(a)
                              Leased Real Property


1.       Leases, between the Company and Oregon Biotechnology Innovation Center,
         dated  October 1, 1995,  April 1, 1997,  August 27, 1997 and January 1,
         1998. The aggregate annual rental payable with respect to each lease is
         [***], respectively,  with increases of [***] to go into effect on July
         1, 1998.






                                Schedule 2.10(b)
                                Liens on Property


None






                                Schedule 2.11(a)
                              Intellectual Property


1.       Attached as  Appendix C hereto is a listing of all  patents  issued and
         applied  for as  part  of the  Company's  license  with  Oregon  Health
         Sciences University. (The patent on MC-1 (MSH receptor) issued in 1996,
         a second  patent on MC-2(ACTH)  issued in 1996,  and a patent on EAAT-2
         issued in 1997.)

2.       The registered  owners of each of the patent  applications  and patents
         specified in Appendix A are the  inventors of the  respective  patents.
         All such patents and patent  applications  have been assigned to Oregon
         Health Sciences University.






                                Schedule 2.11(b)
                         Intellectual Property Licenses

1. License agreement between Oregon Health Sciences  University and the Company,
dated February 1, 1997.

2. Collaboration  Agreement between American Home Products Corporation (referred
to in the Agreement as Wyeth-Ayerst) and the Company, dated August 15, 1996.

3. License Agreement between the Company and American Home Products  Corporation
(Wyeth-Ayerst), dated August 15, 1996.

4.  Research and License  Agreement  between the Company and Trega  Biosciences,
Inc., dated May 30, 1997, as amended by a letter dated January 27, 1998.

5. License Agreement between the Company and The Proctor & Gamble Pharmaceutical
Company, dated May 7, 1997.

6.  Sponsored  Research  and  Cooperation  Agreement  between  the  Company  and
Millennium Pharmaceuticals, Inc., dated February 22, 1996, as modified by letter
dated March 13, 1997 [expired].

7. License Agreement  between the Company and ABS Global,  Inc., dated March 29,
1996 [expired].

8.  Research and License  Agreement  between the Company and  Houghten  (Trega),
dated April 27, 1994 [expired].

9. Sponsored  Research  between the Company and Proctor & Gamble,  dated October
15, 1996 [expired].






                                Schedule 2.11(c)
                           Confidentiality Agreements

1.       Two  technicians  formerly  employed  by the  Company  did not sign the
         Company's  form  of   proprietary   information   and   confidentiality
         agreement.  The technology  that they were working on has either become
         obsolete or has been publicly disclosed.






                                Schedule 2.12(a)
                      Agreements, Contracts and Commitments

1.  Consulting  Agreement  between  Roger  Cone  and the  Company  has not  been
documented.

2. Consulting  Agreement between Susan Amara and the Company,  dated November 1,
1996.

3. Consulting Agreement between the Company and Troy Fiddler,  dated January 12,
1998.

4. Employment  Agreement between the Company and Paul Woloshin,  dated March 11,
1996, as amended on March 11, 1997. 

5. Consulting Agreement between the Company and Mike Kavanaugh,  dated September
10, 1996, renewed February 1, 1998.

6.  Employment  Agreement  between the Company and Stephen Kurtz,  dated May 12,
1997.

7. The Company is obligated to indemnify its officers and directors  pursuant to
its  Articles of  Incorporation  and its  Bylaws.  

8. All  agreements  listed in  Schedules  2.10(a) and  2.11(b) are  incorporated
herein by reference.

9. Consulting  Agreement between the Company and Jeffrey Arriza, dated September
10, 1996 [expired].

10. Consulting Agreement between the Company and Richard Simerly,  dated January
20, 1996 [expired].






                                Schedule 2.12(b)
                                    Breaches


None






                                  Schedule 2.13
                          Interested Party Transactions


1.       Certain officers, directors and stockholders of the Company are parties
         to the agreements set forth in Schedule  2.11(b) and Schedule  2.12(a),
         as indicated thereon.






                                  Schedule 2.15
                                   Litigation


None






                                  Schedule 2.19
                   Brokers/Finders Fees; Third Party Expenses


1.       The Company has not  incurred,  nor will it incur,  any  liability  for
         brokerage or finders' fees or agents' commissions or similar charges in
         connection with the Agreement or any transaction contemplated thereby.

2. The Company estimates its Third Party Expenses as follows:

         a.       Legal fees payable to Tonkon Torp LLP for the transaction:
                  [***].

         b.       Legal  fees  payable to Steve  Lieberman  in  connection  with
                  effecting certain conditions to the Agreement: [***]; and

         c.       Fees payable to NNL's accountants: [***].






                                Schedule 2.20(b)
                 Employee Benefit Plans and Employee Agreements


1. The Company has Employment and Consulting Agreements as indicated on Schedule
2.12(a).

2. The Company offers health insurance through PacifiCare.

3.       One of the Company's  part-time employees (a lab technician) comes from
         Latvia and is working under a work permit.

4. The Company has an Option Agreement with each optionee listed on Appendix A.

5.       1997 Stock Incentive Plan, as amended.






                                Schedule 2.20(d)
                            Employee Plan Compliance


None






                                Schedule 2.20(g)
                           Post Employment Obligations


None






                               Schedule 2.20(h)(i)
                              Effect of Transaction


None






                              Schedule 2.20(h)(ii)
                            Excess Parachute Payments


None






                                Schedule 2.20(j)
                                      Labor


None






                                  Schedule 5.10
                             Company Affiliate List

1.       The  Company  believes  that  the  following  persons  are  or  may  be
         "affiliates" of NNL within the meaning of SEC Rule 145:

         [***]







                                  Schedule 5.14
                          Milestone Warrant Holder List

1.       With  respect to Milestone  Warrant  One,  warrants for an aggregate of
         50,000  shares  of  Parent  Common  Stock  (subject  to  adjustment  as
         specified in the Agreement) shall be issued for [***]:

         --------------------------------- ------------------------------------

         Shareholder                        No. of NNL Shares Owned
         --------------------------------- ------------------------------------
         [***]                                       [***]
           
         --------------------------------- ------------------------------------
         Total                                      750,000
         --------------------------------- ------------------------------------

         [***].

2.       With  respect to Milestone  Warrant  Two,  warrants for an aggregate of
         50,000  shares  of  Parent  Common  Stock  (subject  to  adjustment  as
         specified in the Agreement)  will be  distributed  pro rata pursuant to
         the NNL ownership table shown in the preceding  paragraph  (without the
         [***] described in the last sentence of that paragraph).