As filed with the Securities and Exchange Commission on September 15, 1999 Registration No. 333- ================================================================================ SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT Under The Securities Act of 1933 NEUROCRINE BIOSCIENCES, INC. (Exact name of Company as specified in its charter) Delaware 33-0525145 (State of incorporation) (I.R.S. Employer Identification No.) 10555 Science Center Drive San Diego, California 92121 (Address, including zip code, of Company's principal executive offices) AMENDED 1992 INCENTIVE STOCK PLAN (Full title of the plan) GARY A. LYONS President, Chief Executive Officer and Director 10555 Science Center Drive San Diego, California 92121 (619) 658-7600 (Name, address, and telephone number, including area code, of agent for service) Copies to: Michael W. Sturrock, Esq. Latham & Watkins 633 West Fifth Street, Suite 4000 Los Angeles, California 90071 (213) 485-1234 CALCULATION OF REGISTRATION FEE ________________________________________________________________________________ Proposed Proposed Maximum Maximum Title of Each Class Amount of Shares Offering Aggregate Amount of of Securities to to be Price Offering Registration be Registered Registered(1) Per Share(2) Price(2) Fee(3) ________________________________________________________________________________ Common Stock $0.001 par value 600,000 $ 4.78125 $ 2,868,750 $ 797.51 ____________________ (1) The Amended 1992 Incentive Plan (the "Plan") authorizes the issuance of a maximum of 5,300,000 shares of common stock of Neurocrine Biosciences, Inc. (the "Company") plus substitutions or adjustments to shares to account for any change in corporate capitalization, such as a stock split, any merger, consolidation, recapitalization or other distribution of stock or property. The Company previously registered 3,300,000, 800,000 and 600,000 shares of common stock under the Plan on October 21, 1996, July 22, 1997 and June 26, 1998, respectively. (2) Estimated solely for purposes of computing the registration fee for the 600,000 additional shares registered herewith. Pursuant to Rule 457(c), the proposed Maximum Offering Price Per Share is based on the high and low trading prices of the Company's common stock as reported on the Nasdaq National Market System on September 10, 1999. (3) Relates solely to the 600,000 additional shares registered herewith. ================================================================================ On May 21, 1999, the stockholders of Neurocrine Biosciences, Inc., a Delaware corporation (the "Company"), approved an amendment to the Company's Amended 1992 Incentive Stock Plan (the "Plan") to increase the number of shares of common stock, par value $0.001 per share, of the Company (the "Common Stock") reserved for issuance thereunder from 4,700,000 to 5,300,000. This Registration Statement on Form S-8 (this "Registration Statement") is being filed by the Company to increase the number of shares of Common Stock registered under the Plan to 5,300,000 shares. The Company previously filed Registration Statements on Form S-8 on October 21, 1996 (File No. 333-14589), July 22, 1997 (File no. 333-31791) and June 26, 1998 (File No. 333-57875) to register 3,300,000, 800,000 and 600,000 shares under the Plan, respectively. The contents of such Registration Statements are incorporated herein by reference. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT Item 3. Incorporation of Documents by Reference. The following documents filed with the Securities and Exchange Commission (the "Commission") by the Company, are incorporated by reference in this Registration Statement. (a) The Company's Annual Report on Form 10-K for the fiscal year ended December 31, 1998; (b) The Company's Quarterly Report on Form 10-Q for the quarterly period ended March 31, 1999; and (c) The Company's Quarterly Report on Form 10-Q for the quarterly period ended June 30, 1999. All documents filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), after the date of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, are incorporated by reference in this Registration Statement and are a part hereof from the date of filing such documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement. Item 4. Description of Securities. Not required to be filed with this Registration Statement. Item 5. Interests of Named Experts and Counsel. Not applicable. Page II-1 Item 6. Indemnification of Directors and Officers. Section 145 of the Delaware General Corporation Law generally allows the Company to indemnify directors and officers for all expenses, judgments, fines and amounts in settlement actually paid and reasonably incurred in connection with any proceedings so long as such party acted in good faith and in a manner reasonably believed to be in or not opposed to the Company's best interests and, with respect to any criminal proceedings, if such party had no reasonable cause to believe his or her conduct to be unlawful. Indemnification may only be made by the Company if the applicable standard of conduct set forth in Section 145 has been met by the indemnified party upon a determination made (i) by the Board of Directors by a majority vote of the directors who are not parties to such proceedings, even though less than a quorum, or (ii) if there are no such directors, or if such directors so direct, by independent legal counsel in a written opinion, or (iii) by the stockholders. Article VII of the Company's Restated Articles of Incorporation and Article VI, Sections 6.1, 6.2 and 6.3 of the Company's Bylaws provide for indemnification of its directors and officers, and permit indemnification of employees and other agents to the maximum extent permitted by the Delaware General Corporation Law. In addition, the Company has entered into indemnification agreements with its officers and directors. Item 7. Exemption From Registration Claimed. Not applicable. Item 8. Exhibits. The following is a list of exhibits filed as part of this Registration Statement, which are incorporated herein: Exhibit Number Document - ------- ---------------------------------------------------------------- 4.1 Form of Lock-Up Agreement(1). 4.2 Form of Common Stock Certificate(1). 4.3 Form of warrant issued to existing warrant holders(1). 4.4 Form of Series A warrant issued in connection with the execution by the Company of the Unit Purchase Agreement, dated January 19, 1996, by and between the Company, Neuroscience Pharma, Inc. and the investors signatory thereto(1). 4.5 New Registration Rights Agreement, dated March 29, 1996 by and among the Company and the investors signatory thereto(1). 4.6 Letter of Intent between Northwest Neurologic, Inc. and the Company dated February 27, 1998(2). 5.1 Opinion of Latham & Watkins. 10.1 Amended 1992 Incentive Stock Plan. 23.1 Consent of Ernst & Young LLP, Independent Auditors. 23.2 Consent of Latham & Watkins (contained in Exhibit 5.1). 24.1 Power of Attorney (see page II-5). - --------------------- (1) Incorporated by reference to the Company's Registration Statement filed on April 3, 1996 on Form S-1, as amended (File No. 333-03172). (2) Incorporated by reference to the Company's Report on Form 8-K filed on March 13, 1998. Page II-2 Item 9. Undertakings. (a) The undersigned Company hereby undertakes: (1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement to include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement. (2) That, for purposes of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. (3) To remove from registration by means of post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. (b) The undersigned Company hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Company's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. (c) Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Company pursuant to the Delaware General Corporation Law, the Restated Articles of Incorporation or the Bylaws of the Company, Indemnification Agreements entered into between the Company and its officers and directors, or otherwise, the Company has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Company of expenses incurred or paid by a director, officer or controlling person of the Company in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered hereunder, the Company will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. Page II-3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on this 15th day of September, 1999. NEUROCRINE BIOSCIENCES, INC. By: /s/ Gary A. Lyons Gary A. Lyons President and Chief Executive Officer Page II-4 POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each such person whose signature appears below constitutes and appoints, jointly and severally, Gary A. Lyons and Paul W. Hawran his attorneys-in-fact, each with the power of substitution, for him in any and all capacities, to sign any amendments to this Registration Statement on Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that each of said attorneys-in-fact, or his substitute or substitutes, may do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated. Signature Title Date - --------------------- ------------------------------ ----------------- /s/ Gary A. Lyons President, Chief Executive September 14, 1999 - ------------------------ Officer and Director Gary A. Lyons (Principal Executive Officer) /s/ Paul W. Hawran Chief Financial Officer September 14, 1999 - ------------------------ (Principal Financing and Paul W. Hawran Accounting Officer) /s/ Joseph A. Mollica Chairman of the September 14, 1999 - ------------------------ Board of Directors Joseph A. Mollica /s/ Harry F. Hixson, Jr. Director September 14, 1999 - ------------------------ Harry F. Hixson, Jr. /s/ Richard F. Pops Director September 14, 1999 - ------------------------ Richard F. Pops /s/ Wylie W. Vale Director September 14, 1999 - ------------------------ Wylie W. Vale /s/ Stephen A. Sherwin Director September 14, 1999 - ------------------------ Stephen A. Sherwin Page II-5 INDEX TO EXHIBITS Exhibit Number Document - --------- ---------------------------------------------------------------- 4.1 Form of Lock-Up Agreement(1). 4.2 Form of Common Stock Certificate(1). 4.3 Form of warrant issued to existing warrant holders(1). 4.4 Form of Series A warrant issued in connection with the execution by the Company of the Unit Purchase Agreement, dated January 19, 1996, by and between the Company, Neuroscience Pharma, Inc. and the investors signatory thereto(1) 4.5 New Registration Rights Agreement, dated March 29, 1996 by and among the Company and the investors signatory thereto(1). 4.6 Letter of Intent between Northwest NeuroLogic, Inc. and the Company dated February 27, 1998(2). 5.1 Opinion of Latham & Watkins. 10.1 Amended 1992 Incentive Stock Plan. 23.1 Consent of Ernst & Young LLP, Independent Auditors. 23.2 Consent of Latham & Watkins (contained in Exhibit 5.1). 24.1 Power of Attorney (see page II-5). - ---------------------- (1) Incorporated by reference to the Company's Registration Statement filed on April 3, 1996 on Form S-1, as amended (File No. 333-03172). (2) Incorporated by reference to the Company's Report on Form 8-K filed on March 13, 1998. Page II-6