EXECUTION COPY


                                 FIRST AMENDMENT


         FIRST AMENDMENT dated as of February 15, 2006 (this "Amendment"), among
INTEGRA LIFESCIENCES HOLDINGS CORPORATION, a Delaware corporation (the
"Borrower"), the lenders party to the Credit Agreement (as defined below)
(collectively, the "Lenders"), BANK OF AMERICA, N.A., as Administrative Agent,
Swing Line Lender and L/C Issuer (the "Administrative Agent"), CITIBANK, FSB and
SUNTRUST BANK, as Co-Syndication Agents (the "Co-Syndication Agents") and ROYAL
BANK OF CANADA and WACHOVIA BANK, NATIONAL ASSOCIATION, as Co-Documentation
Agents (the "Co-Documentation Agents").

         PRELIMINARY STATEMENTS:

         (1)      The Borrower, the Lenders, the Administrative Agent, the
                  Co-Syndication Agents and the Co-Documentation Agents have
                  entered into a Credit Agreement, dated as of December 22, 2005
                  (as the same may be amended, supplemented or otherwise
                  modified from time to time, the "Credit Agreement" and the
                  Credit Agreement, as amended by, and together with this
                  Amendment, the "Amended Agreement"). Capitalized terms used
                  but not defined in this Amendment shall have the meanings
                  assigned to them in the Credit Agreement.

         (2)      The Borrower has requested the Lenders to amend certain
                  provisions of the Credit Agreement.

         NOW, THEREFORE, in consideration of the premises and of the mutual
covenants and agreements contained herein, the parties hereto agree as follows:

         SECTION 1.01. Amendment to Section 1.01. The definition of "Permitted
Acquisition" set forth in Section 1.01 of the Credit Agreement is hereby amended
by deleting the words "by any Loan Party" from the first line thereof.

         SECTION 1.02. Amendment to Section 7.03. Section 7.03(e) of the Credit
Agreement is hereby deleted in its entirety and replaced with the following:

                  "(e) intercompany Indebtedness constituting an Investment that
                  is permitted under Sections 7.02(d), (e), (f) or (g)."

         SECTION  1.03.  Representations  and  Warranties.  The  Borrower
hereby  represents  and  warrants to the Administrative Agent and the Lenders,
as follows:

                  (a) After giving effect to the updated Schedules to the Credit
         Agreement attached hereto, the representations and warranties set forth
         in Article V of the Credit Agreement and in each other Loan Document
         are true and correct in all material respects on and as of the date
         hereof and on and as of the Amendment Effective Date (as defined below)
         with the same effect as though made on and as of the date hereof or the



         Amendment Effective Date, as the case may be, except to the extent such
         representations and warranties expressly relate to an earlier date (in
         which case such representations and warranties shall be true and
         correct in all material respects on and as of such earlier date).

                  (b) On the date hereof and on the Amendment Effective Date, no
         Default or Event of Default has occurred and is continuing.

                  (c) The execution, delivery and performance of this Amendment
         by the Borrower and each of its Subsidiaries have been duly authorized
         by all requisite corporate or other organizational action.

                  (d) This Amendment constitutes the legal, valid and binding
         obligation of the Borrower and each of its Subsidiaries, enforceable
         against each such party in accordance with its terms.

                  (e) The execution, delivery and performance of this Amendment
         by the Borrower and each of its Subsidiaries do not and will not (i)
         contravene the terms of any of such Person's Organization Documents;
         (ii) conflict with or result in any breach or contravention of, or
         (except for the Liens created under the Loan Documents) the creation of
         any Lien under, or require any payment to be made under (A) any
         Contractual Obligation to which such Person or such Person's Affiliate
         is a party or affecting such Person or the properties of such Person or
         any of its subsidiaries or (B) any order, injunction, writ or decree of
         any Governmental Authority or any arbitral award to which such Person
         or its property is subject; or (iii) violate any Law.

         SECTION 1.04. Effectiveness. This Amendment shall become effective only
upon satisfaction of the following conditions precedent (the first date upon
which each such condition has been satisfied being herein called the "Amendment
Effective Date"):

                  (a) The Administrative Agent shall have received duly executed
         counterparts of this Amendment which, when taken together, bear the
         authorized signatures of the Borrower, each Subsidiary Guarantor and
         the Required Lenders.

                  (b) The representations and warranties set forth in Section
         1.03 shall be true and correct on and as of the Amendment Effective
         Date.

                  (c) The Lenders shall have received such other documents,
         legal opinions, instruments and certificates as they shall reasonably
         request and such other documents, legal opinions, instruments and
         certificates shall be satisfactory in form and substance to the Lenders
         and their counsel. All corporate and other proceedings taken or to be
         taken in connection with this Amendment and all documents incidental
         thereto, whether or not referred to herein, shall be satisfactory in
         form and substance to the Lenders and their counsel.

         SECTION 1.05. APPLICABLE LAW. THIS AMENDMENT SHALL BE GOVERNED BY, AND
CONSTRUED IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK WITHOUT REFERENCE
TO THE CONFLICTS OF LAWS PRINCIPLES THEREOF.




         SECTION 1.06. Fees and Expenses. The Borrower shall pay all reasonable
out-of-pocket expenses incurred by the Administrative Agent in connection with
the preparation, negotiation, execution, delivery and enforcement of this
Amendment, including, but not limited to, the reasonable fees and disbursements
of counsel.

         SECTION 1.07. Counterparts. This Amendment may be executed in any
number of counterparts, each of which shall constitute an original but all of
which when taken together shall constitute but one agreement. Delivery by
facsimile by any of the parities hereto of an executed counterpart of this
Amendment shall be as effective as an original executed counterpart hereof and
shall be deemed a representation that an original executed counterpart hereof
will be delivered, but the failure to deliver a manually executed counterpart
shall not affect the validity, enforceability or binding effect of this
Amendment.

         SECTION 1.08. Guarantor Confirmation. By its execution and delivery
hereof, each Subsidiary Guarantor acknowledges and agrees that, as provided in
Article II of the Subsidiary Guaranty, such Subsidiary Guarantor's obligations
under the Subsidiary Guaranty shall not be released, diminished, impaired,
reduced or adversely affected by the execution, delivery or performance of this
Amendment, and waives any rights which such Subsidiary Guarantor might otherwise
have to make any claim to the contrary. Each Subsidiary Guarantor hereby
confirms that the Subsidiary Guaranty is, and after the effectiveness of this
Amendment shall remain, in full force and effect, and enforceable against such
Subsidiary Guarantor in accordance with its terms. Each Subsidiary Guarantor
hereby acknowledges that the Administrative Agent and the Lenders are relying
upon the foregoing agreements of such Subsidiary Guarantor in entering into this
Amendment.

         SECTION 1.09. Credit Agreement. Except as expressly set forth herein,
the amendments provided herein shall not by implication or otherwise limit,
constitute a waiver of, or otherwise affect the rights and remedies of the
Lenders or the Administrative Agent under the Credit Agreement or any other Loan
Document, nor shall they constitute a waiver of any Default or Event of Default,
nor shall they alter, modify, amend or in any way affect any of the terms,
conditions, obligations, covenants or agreements contained in the Credit
Agreement or any other Loan Document. Each of the amendments provided herein
shall apply and be effective only with respect to the provisions of the Credit
Agreement specifically referred to by such amendment. Except as expressly
amended herein, the Credit Agreement shall continue in full force and effect in
accordance with the provisions thereof. As used in the Credit Agreement, the
terms "Agreement", "herein", "hereinafter", "hereunder", "hereto" and words of
similar import shall include, from and after the Amendment Effective Date, the
Amended Agreement.








         IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
duly executed by their duly authorized officers, all as of the date first above
written.


                                          Borrower:

                                          INTEGRA LIFESCIENCES HOLDINGS
                                          CORPORATION, a Delaware corporation


                                          By:/s/ David B. Holtz
                                          --------------------------------
                                          Name: David B. Holtz
                                          Title: Senior Vice President, Finance


                                          Subsidiary Guarantors:

                                          INTEGRA LIFESCIENCES CORPORATION,
                                          a Delaware corporation


                                          By:/s/ David B. Holtz
                                          --------------------------------
                                          Name: David B. Holtz
                                          Title: Senior Vice President, Finance


                                          INTEGRA LIFESCIENCES INVESTMENT
                                          CORPORATION, a Delaware corporation


                                          By: /s/ David B. Holtz
                                          --------------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer


                                          INTEGRA OHIO, INC., a Delaware
                                          corporation


                                          By: /s/ David B. Holtz
                                          --------------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer








                                          INTEGRA RADIONICS, INC., a
                                          Delaware corporation


                                          By:  /s/ David B. Holtz
                                          -------------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer


                                          INTEGRA CLINICAL EDUCATION
                                          INSTITUTE, INC., a Delaware
                                          corporation

                                          By:  /s/ David B. Holtz
                                          -------------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer


                                          INTEGRA HEALTHCARE PRODUCTS LLC,
                                          a Delaware limited liability
                                          company


                                          By:  Integra LifeSciences
                                               Corporation, its sole member


                                          By: /s/ David B. Holtz
                                          -----------------------------
                                          Name: David B. Holtz
                                          Title: Senior Vice President, Finance


                                          J. JAMNER SURGICAL INSTRUMENTS,
                                          INC., a Delaware corporation


                                          By:  /s/ David B. Holtz
                                          -----------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer









                                          JARIT INSTRUMENTS, INC., a
                                          Delaware corporation


                                          By: /s/ David B. Holtz
                                          ------------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer


                                          INTEGRA SELECTOR CORPORATION, a
                                          Delaware corporation


                                          By: /s/ David B. Holtz
                                          -----------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer



                                          SPINAL SPECIALTIES, INC., a
                                          Delaware corporation


                                          By: /s/ David B. Holtz
                                          -----------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer


                                          INTEGRA NEUROSCIENCES (IP), INC.,
                                          a Delaware corporation


                                          By: /s/ David B. Holtz
                                          -----------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer


                                          INTEGRA NEUROSCIENCES
                                          (INTERNATIONAL), INC., a Delaware
                                          corporation


                                          By: /s/ David B. Holtz
                                          -----------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer




                                          INTEGRA LIFESCIENCES (FRANCE) LLC,
                                          a Delaware limited liability company


                                          By:  Integra NeuroSciences
                                               (International), Inc., its
                                               sole member


                                          By: /s/ David B. Holtz
                                          -----------------------------
                                          Name: David B. Holtz
                                          Title: Vice President and Treasurer






                                        BANK OF AMERICA, N.A., as Administrative
                                        Agent, Swing Line Lender, L/C Issuer and
                                        as a Lender


                                        By: /s/ Amie L. Edwards
                                        ----------------------------------
                                        Name: Amie L. Edwards
                                        Title: Vice President








                                         CITIBANK, FSB, as Co-Syndication Agent
                                         and as a Lender


                                         By:
                                         -----------------------------------
                                         Name:
                                         Title:







                                         SUNTRUST BANK, as Co-Syndication Agent
                                         and as a Lender


                                         By: /s/ Gregory M. Ratliff
                                         ----------------------------------
                                         Name: Gregory M. Ratliff
                                         Title: Vice President







                                      ROYAL BANK OF CANADA, as Co-Documentation
                                      Agent and as a Lender


                                      By: /s/ Gordon MacArthur
                                      ----------------------------------
                                      Name: Gordon MacArthur
                                      Title: Authorized Signatory








                                       WACHOVIA BANK, NATIONAL ASSOCIATION, as
                                       Co-Documentation Agent and as a Lender


                                       By: /s/ Jeanette A. Griffin
                                       ----------------------------------
                                       Name: Jeanette A. Griffin
                                       Title: Director







                                       CITIZENS BANK PA, as a Lender


                                       By: /s/ Mark W. Torie
                                       ----------------------------------
                                       Name: Mark W. Torie
                                       Title:SVP




                                       PNC BANK NATIONAL ASSOCIATION, as a
                                       Lender


                                       By: /s/ Phillip J. Clark
                                       ----------------------------------
                                       Name: Phillip J. Clark
                                       Title: Vice President






                                       SOVEREIGN BANK, as a Lender


                                        By: /s/ John T. Harrison
                                        -----------------------------------
                                        Name: John T. Harrison
                                        Title: Senior Vice President





                                        THE BANK OF NEW YORK, as a Lender


                                        By: /s/ Stephen G. Necel
                                        -----------------------------------
                                        Name: Stephen G. Necel
                                        Title: Vice President








                                        DRESDNER BANK AG, NEW YORK AND GRAND
                                        CAYMAN BRANCHES, as a Lender


                                        By:
                                        ------------------------------------
                                        Name:
                                        Title:



                                        By:
                                        ------------------------------------
                                        Name:
                                        Title:






                                        HSBC BANK USA, NA, as a Lender


                                        By:
                                        ------------------------------------
                                        Name:
                                        Title:






                                        COMMERCE BANK, N.A., as a Lender


                                        By: /s/ Daniel R. Vereb
                                        ------------------------------------
                                        Name: Daniel R. Vereb
                                        Title: Vice President






                                        PEOPLE'S BANK, as a Lender


                                        By: /s/ George F. Paik
                                        ------------------------------------
                                        Name: George F. Paik
                                        Title: Vice President






                                         BROWN BROTHERS HARRIMAN & CO, as
                                         a Lender


                                         By: /s/ John D. Rogers
                                         --------------------------------
                                         Name: John D. Rogers
                                         Title: Senior Vice President






                                          COMERICA BANK, as a Lender


                                          By: /s/ Neran Shaya
                                          ---------------------------------
                                          Name: Neran Shaya
                                          Title:Vice President