Seward & Kissel LLP
                               1200 G Street, N.W.
                             Washington, D.C. 20005
                            Telephone: (202) 737-8833
                            Facsimile: (202) 737-5184
                                 www.sewkis.com

                                                April 11, 2008

VIA EDGAR

Ms. Sally Samuel, Senior Counsel
Office of Insurance Products
Division of Investment Management
Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549

          Re:  AllianceBernstein Variable Products Series Fund, Inc. -
                 U.S. Government/High Grade Securities Portfolio
               Post-Effective Amendment No. 44
               File Nos. 033-18647 and 811-05398
               ---------------------------------

Dear Ms. Samuel:

     This letter responds to comments of the staff (the "Staff") of the
Securities and Exchange Commission (the "SEC") to the post-effective amendment
to the registration statement filed on Form N-1A including the Prospectus and
Statement of Additional Information ("SAI") for U.S. Government/High Grade
Securities Portfolio (the "Portfolio"), a series of AllianceBernstein Variable
Products Series Fund, Inc. ("AVP"), as provided orally to Young Seo of this
office on April 8, 2008.

     As background, the Portfolio will acquire four other AVP portfolios on
April 25, 2008. We had intended to file an amended registration under Rule
485(a) that would go effective automatically on the 60th day or May 1, 2008.
However, by the time we realized that the merger would occur prior to that date
and we would need an effective registration statement by April 28, 2008, we had
to file the amended registration statement with a request for acceleration. We
need to furnish the printed prospectus to the insurance companies that use the
Portfolio as an underlying fund for a variable annuity product to incorporate
into their documents by early next week notwithstanding that the prospectus will
not be effective or used until April 28, 2008. Under the circumstances, we need
to discuss and resolve any issues with the Staff's comments by early next week.
While this is a short time frame for your consideration of our responses below,
we would appreciate your assistance in this regard.

     Also, as a preliminary matter, we have issues with several of the comments
because they involve revisions to the standardized prospectuses used by all of
the 18 AVP portfolios as well as over 70 AllianceBernstein retail mutual funds.
We appreciate that the fact that there is a standardized form of the
prospectuses for all of these funds should not necessarily be a response to a
Staff comment. However, all of these prospectuses have been previously reviewed
on numerous occasions by the Staff of both the Office of Insurance Products and
the Office of Disclosure Review. In fact, the very same form of prospectus was
filed in March 2006 (Post-Effective Amendment No. 41) and reviewed by the Staff
of the Office of Insurance Products. We did not receive any Staff comments on
the form of the prospectus equivalent to some of the comments discussed below.
We request that the Staff reconsider whether these comments are necessary in
light of the extensive Staff review of these prospectuses.

     The Staff's comments and our responses are discussed below.(1)

- ----------
(1)  Capitalized terms have the same meaning as in the Prospectus unless
     otherwise defined.

Comment 1:  Summary Information: "Credit Ratings" and "Other Information" in the
            "Summary Information" section should be deleted or moved back so
            that the fee table can be moved up closer to the front of the
            Prospectus.

Response:   The "Summary Information" section is part of the risk/return summary
            required by Item 2 of Form N-1A. It highlights certain information
            about performance, risks, credit ratings and maturity and duration.
            In particular, the description of the Portfolio's investment
            strategies refers to credit ratings and maturity and duration. We
            believe it is important for investors to have this disclosure in
            order to facilitate their understanding of the subsequent, more
            focused, description of the Portfolio's investment strategies. We
            believe that this information is responsive to the disclosure
            required by Item 2 of Form N-1A. This disclosure format has, as
            noted above, been previously reviewed by the Staff.

Comment 2:  Objectives and Principal Strategies: The "Principal Risks" section
            should only identify the principal risks of investing in the
            Portfolio. If any of the risks identified here is not a principal
            risk, it should be moved to the back. Also, the disclosure does not
            state where the risks are defined.

Response:   Only principal risks are identified in the "Principal Risks"
            section. The disclosure also instructs an investor to see "Risks
            Summary" for a broader discussion of these and other risks of
            investing in the Portfolio.

Comment 3:  Fees and Expenses of the Portfolio: The fee table should be moved up
            closer to the front of the Prospectus and should follow right after
            the performance table.

Response:   The fee table is in the order prescribed by Form N-1A and follows
            disclosure about the Portfolio's investment objective, principal
            strategies and risks, and performance. The fee table is proximately
            located near the front of the Prospectus, clearly identified in the
            table of contents and easily accessible to any investor who may want
            to review the fees for an underlying fund for a variable annuity
            contract, such as the Portfolio, although more comprehensive fee
            information about their contract is available in the variable
            contract prospectus.

Comment 4:  Frequent Purchases and Redemptions of Portfolio Shares: The second
            sentence in the second paragraph under "Risks Associated With
            Excessive Or Short-Term Trading Generally" should be revised to
            conform to the NAV calculation disclosure in other places of the
            Prospectus. A parallel change should be made to the SAI.

Response:   We have revised the Prospectus and the SAI in response to this
            comment.

Comment 5:  More Information About the Portfolio and Its Investments: The
            "Derivatives" section should include a disclosure regarding the
            Portfolio's obligation to set aside liquid assets or cash, and the
            risks associated with such practice. One way to make this disclosure
            is to identify the obligation in the Prospectus and describe it more
            fully in the SAI. But this disclosure needs to be in both the
            Prospectus and the SAI.

Response:   Form N-1A does not require disclosure in the Prospectus about the
            Portfolio's obligation to set aside liquid assets or cash to
            collateralize the market risk of derivatives transactions. See
            Footnote 143 in Registration Form Used By Open-End Management
            Investment Companies, Investment Company Act Release No. 23064
            (March 13, 1998). We have added additional disclosure to the SAI
            about the segregation of assets relating to derivatives
            transactions.

Comment 6:  More Information About the Portfolio and Its Investments: The
            "Illiquid Securities" section should include a disclosure that in
            the event the Portfolio's investments in illiquid securities exceed
            15% of its net assets, it would take steps necessary to bring the
            percentage down to 15% or less. A parallel disclosure should be
            included in the SAI.

Response:   We do not believe that Form N-1A requires disclosure about the
            Portfolio reducing its investments in illiquid securities if these
            investments exceed 15% of net assets. This disclosure merely
            restates the Portfolio's legal obligation. We believe that it adds
            unnecessary length and complexity to the Prospectus. We have added
            additional disclosure to the SAI in response to this comment.

Comment 7:  More Information About the Portfolio and Its Investments: If the
            Portfolio has any sub-prime mortgage related investments, the
            "Mortgage-Backed Securities" section should include a disclosure
            regarding such investments. A parallel disclosure should be included
            in the SAI.

Response:   The Portfolio has a very small amount of sub-prime mortgage related
            investments. Items 2 and 4 of Form N-1A require disclosure of a
            fund's principal investment strategies, including the particular
            type or types of investments in which the [f]und principally invests
            or will invest." According to Form N-1A, principal risk disclosure
            should focus on `the risks to which the [f]und's portfolio as a
            whole is subject and the circumstances most likely to affect
            adversely the [f]und's net asset value, yield and total return."
            These investments are not a principal strategy of the Portfolio and
            do not constitute a principal risk. The SAI disclosure includes
            disclosure about sub-prime mortgage related investments and their
            risks.

Comment 8:  More Information About the Portfolio and Its Investments: The
            "Investment in Below Investment Grade Fixed-Income Securities"
            section should include a disclosure that states that these
            investments are typically identified as "junk bonds."

Response:   We have revised the disclosure in response to this comment.

Comment 9:  Management of the Portfolio: The "Investment Adviser" section should
            include a disclosure of the aggregate amount of paid by the
            Portfolio to the Adviser for its investment advisory services.

Response:   Form N-1A does not require this information in the Prospectus. It is
            included in the SAI.

Comment 10: Management of the Portfolio: The cross-reference to the SAI for
            additional information about the Portfolio Managers in the last
            sentence in the "Portfolio Managers" section should refer to a more
            specific section of the SAI.

Response:   We have revised the Prospectus in response to this comment.

Comment 11: A disclosure regarding the voting rights of the contractowners,
            including one on "proportional voting" that, as a result of
            proportional voting, a small number of contractowners can determine
            the outcome of the vote, should be included. A parallel disclosure
            should be included in the "General Information" section of the SAI.

Response:   We do not believe that Form N-1A requires disclosure in the
            Prospectus regarding the voting rights of contractowners. In
            response to comments received in the Staff review in 2006, we
            included this disclosure in the SAI.

Comment 12: "Appendix B" and the back cover page appear to be on the same page.

Response:   We have revised the Prospectus in response to this comment.

Comment 13: Part C: A disclosure regarding indemnification, required under Rule
            484, should be included.

Response:   We have revised Part C to include disclosure regarding
            indemnification.

                                           * * *


     We hereby acknowledge that (i) the Fund is responsible for the adequacy and
accuracy of the disclosures in the filings; (ii) Staff comments or changes to
disclosures in response to Staff comments in the filings reviewed by the Staff
do not foreclose the SEC from taking any action with respect to the filings; and
(iii) the Fund may not assert Staff comments as a defense in any proceedings
initiated by the SEC or any person under the federal securities laws of the
United States.

     If you have any additional comments or questions, please contact the
undersigned at (202) 737-8833.

                                        Sincerely,


                                        /s/ Kathleen K. Clarke

cc: Christina Morse, Esq.

SK 00250 0292 872740