SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C.  20549

                                   FORM 11-K

                                 ANNUAL REPORT

                        Pursuant to Section 15(d) of the
                        Securities Exchange Act of 1934

                      For the year ended December 31, 2000

                             MILLIPORE CORPORATION
          (Name of issuer of the securities held Pursuant to the Plan)

                                 80 Ashby Road
                         Bedford, Massachusetts  01730
                   (Address of the principal executive office
                                 of the issuer)


                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
Committee has duly caused this Annual Report to be signed by the undersigned
thereunto duly authorized.



                                         MILLIPORE CORPORATION
                                         EMPLOYEES' PARTICIPATION
                                         AND SAVINGS PLAN



                                         BY:/s/Jeffrey Rudin
                                         Jeffrey Rudin
                                         Committee for Administration
                                         of the Millipore Corporation
                                         Employees' Participation and
                                         Savings Plan



Date:      June 28, 2001



                             MILLIPORE CORPORATION
                   EMPLOYEES' PARTICIPATION AND SAVINGS PLAN

                      For the Year Ended December 31, 2000

                 MILLIPORE CORPORATION EMPLOYEES' PARTICIPATION
                                AND SAVINGS PLAN

           Index to Financial Statements and Supplemental Schedules *



Financial Statements                                                     Page(s)

Report of Independent Accountants                                           1

Statements of Net Assets Available for Plan Benefits
as of December 31, 2000 and 1999                                            2

Statement of Changes in Net Assets Available for Plan
Benefits for the year ended December 31, 2000                               3

Notes to Financial Statements                                             4 - 9

Schedule of Assets Held for Investment Purposes
as of December 31, 2000                                                     10

*    Certain supplemental schedules have been omitted as they are either not
     required or because the required information has been included elsewhere in
     the financial statements.



                       Report of Independent Accountants
                       ---------------------------------


To the Participants and Administrator of
the Millipore Employees' Participation and
Savings Plan

In our opinion, the accompanying statements of assets available for plan
benefits and the related statement of changes in assets available for plan
benefits present fairly, in all material respects, the assets available for plan
benefits of Millipore Employees' Participation and Savings Plan (the "Plan") at
December 31, 2000 and 1999, and the changes in assets available for plan
benefits for the year ended December 31, 2000 in conformity with accounting
principles generally accepted in the United States of America.  These financial
statements are the responsibility of the Plan's management; our responsibility
is to express an opinion on these financial statements based on our audits.  We
conducted our audits of these statements in accordance with auditing standards
generally accepted in the United States of America, which require that we plan
and perform the audit to obtain reasonable assurance about whether the financial
statements are free of material misstatement.  An audit includes examining, on a
test basis, evidence supporting the amounts and disclosures in the financial
statements, assessing the accounting principles used and significant estimates
made by management, and evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.

Our audits were conducted for the purpose of forming an opinion on the basic
financial statements taken as a whole. The supplemental schedule of assets held
is presented for the purpose of additional analysis and is not a required part
of the basic financial statements but is supplementary information required by
the Department of Labor's Rules and Regulations for Reporting and Disclosure
under the Employee Retirement Income Security Act of 1974 ("ERISA").  This
supplemental schedule is the responsibility of the Plan's management.  The
supplemental schedule has been subjected to the auditing procedures applied in
the audits of the basic financial statements and, in our opinion, is fairly
stated in all material respects in relation to the basic financial statements
taken as a whole.

The schedule of assets held that accompanies the Plan's financial statements
does not disclose the historical cost of non-participant directed Plan
investments.  This information is required by the Department of Labor's Rules
and Regulations for Reporting and Disclosure under ERISA.



Boston, Massachusetts
June 8, 2001

                                       1


                             MILLIPORE CORPORATION
                   EMPLOYEES' PARTICIPATION AND SAVINGS PLAN
                STATEMENT OF ASSETS AVAILABLE FOR PLAN BENEFITS



                                                           December 31,

                                                     2000              1999
                                                 ------------      ------------
Assets
- ------

Investments, at fair value                       $173,584,742      $166,747,991
Investment in insurance company,
  at contract value                                   305,570           323,348
                                                 ------------      ------------
Total investments                                 173,890,312       167,071,339

Participant loans receivable                        3,666,552         3,778,798

Contributions receivable:
  Participation Account                             5,615,169         5,016,613
                                                 ------------      ------------

Assets available for plan benefits               $183,172,033      $175,866,750
                                                 ============      ============

    The accompanying notes are an integral part of the financial statements.

                                       2


                             MILLIPORE CORPORATION
                   EMPLOYEES' PARTICIPATION AND SAVINGS PLAN
           STATEMENT OF CHANGES IN ASSETS AVAILABLE FOR PLAN BENEFITS
                      For the year ended December 31, 2000


Investment income:

  Dividends on Millipore Common Stock                              $    108,310

  Dividends and interest                                              5,776,635

  Net appreciation in fair value of investments                         335,041
                                                                   ------------

Total investment Income                                               6,219,986

Contributions:

  Employer contributions:

    Participation Account                                             5,615,169

    Savings Account                                                   1,817,554

    Employee Savings Account contributions                            9,151,882
                                                                   ------------

Total contributions                                                  16,584,605

Benefit payments                                                    (15,495,673)

Other expense                                                            (3,635)
                                                                   ------------

Net increase                                                          7,305,283

Assets available for plan benefits at January 1                     175,866,750
                                                                   ------------

Assets available for plan benefits at December 31                  $183,172,033
                                                                   ============

    The accompanying notes are an integral part of the financial statements.

                                       3


                             MILLIPORE CORPORATION
                   EMPLOYEES' PARTICIPATION AND SAVINGS PLAN

                         Notes to Financial Statements

A.  Description of the Plan
    -----------------------

     General
     -------

     The following description of the Millipore Corporation (the "Company")
     Employees' Participation and Savings Plan (the "Plan") provides only
     general information.  Participants should refer to the Plan document for a
     more complete description of the Plan's provisions.

     The Plan is a defined contribution profit sharing plan subject to the
     provisions of the Employee Retirement Income Security Act of 1974 (ERISA)
     and was most recently amended and restated effective January 1, 1997.

     The Plan includes a profit sharing feature (the "Participation Account"),
     which covers U.S. and Puerto Rico employees who have at least two years of
     continuous service with the Company, and a savings feature (the "Savings
     Account"), which covers only U.S. employees.  Eligible employees can
     contribute to the Savings Account upon service commencement date, and the
     Company match will begin after one year of continuous service.

     Effective August 1, 1999, T. Rowe Price Retirement Plan Service, Inc.
     replaced Watson Wyatt Worldwide as recordkeeper of the Plan.  Effective
     August 1, 1999, T. Rowe Price Trust Company replaced Investor's Bank &
     Trust as trustee of the Plan.  As a result of this change in Trustee, all
     new investment options were introduced with the exception of the Millipore
     Stock Fund.

     Funding Policy
     --------------

     Under the Participation Account, the Company makes discretionary
     contributions to the Plan of a percentage of the Company's profits as
     designated by the Company's Board of Directors.  Contributions are
     allocated to participants' accounts based on participants' compensation
     during the year for which the contribution is made and are invested in the
     Millipore Asset Allocation Fund.  Prior to August 1, 1999, the Millipore
     Asset Allocation Fund was known as the Balanced Fund.  Prior to August 1,
     1999, the Participation Account was commingled in a Master Trust with the
     Retirement Plan for Employees of Millipore Corporation (the "Retirement
     Plan"), a separate plan sponsored by the Company.

     Under the Savings Account, participants may elect to contribute amounts
     ranging from 1% to 16% of their eligible compensation on a pre-tax basis
     subject to certain limitations. All participants with 10 or more years of
     service receive a Company match of 50% of their contribution up to 6% of
     their eligible compensation.  Participants with less than 10 years of
     service receive a Company match of 25% of their contribution up to 6% of
     their eligible compensation.

     Contributions under the Savings Account and the Company's matching amount
     are invested as directed by the participants.  Participants are permitted
     to invest in one or more of the investment vehicles offered, pursuant to
     the provisions of the Plan.

                                      4



                             MILLIPORE CORPORATION
                   EMPLOYEES' PARTICIPATION AND SAVINGS PLAN

                         Notes to Financial Statements

A.   Description of the Plan - (continued)
     -------------------------------------

     Vesting
     -------

     All participants are fully vested in their accounts at all times.

     Investment Options
     ------------------

     A participant may direct contributions under the Savings Account into any
     of the following investment options:

        T. Rowe Price Blue Chip Growth Fund
        T. Rowe Price Equity Index Trust
        T. Rowe Price Summit Cash Reserves Fund
        T. Rowe Price Balanced Fund
        Deutsche International Equity Fund
        Van Kampen Emerging Growth Fund, Class A
        Robertson Stephens (RS) Emerging Growth Fund
        Pimco Total Return Fund
        Millipore Common Stock

     In addition to the above funds, there are investments from a plan acquired
     through a prior acquisition by the Company, which consists of Deposit Fund
     accounts held at Pan American Life Insurance Company.  Employees cannot
     direct contributions to these Deposit Fund accounts.  The Deposit Fund
     accounts hold guaranteed insurance contracts, which will mature over the
     next two years until 2002.  Upon maturity, participants must direct such
     funds into the investment options mentioned above.

     Non-participant directed investments (Participation Account) are invested
     in the Millipore Asset Allocation Fund, formerly the Balanced Fund, which
     is comprised of the following Grantham, Mayo, Van Otterloo Co., LLC ("GMO")
     mutual funds:

        GMO US Core Fund III
        GMO Domestic Bond Fund III
        GMO Small Cap Value Fund III

     Participant Loans
     -----------------

     Participants may borrow from their fund accounts a minimum of $1,000 up to
     a maximum equal to the lesser of, (1) the amount of their total account
     (excluding the Participation Account), (2) the greater of $10,000 or one-
     half of their total account; or (3) $50,000 reduced by the excess (if any)
     of (a) the highest outstanding balance of loans from the Plan during the
     1-year period ending on the day before the date on which such loan was
     made, over (b) the outstanding balance of loans from the Plan on the date
     on which such loan was made. Loan terms range from 1 to 5 years. Loan
     interest rates are updated monthly. As of December 31, 2000, interest rates
     on participant loans ranged from 5.5% to 10.5%. The entire amount of the
     participant's account serves as collateral for the loan.

                                       5



                             MILLIPORE CORPORATION
                   EMPLOYEES' PARTICIPATION AND SAVINGS PLAN

                         Notes to Financial Statements

A.   Description of the Plan - (continued)
     -------------------------------------

     Payment of Benefits
     -------------------

     Participants who are 59 1/2 years or older may, at any time, withdraw
     amounts contributed to the Plan by, or on behalf of them, including income
     earned.  In the event of a participant's death, termination or retirement,
     all amounts contributed to the Plan by, or on behalf of the participant,
     including income earned, will be distributed in accordance with the
     provisions of the Plan.  Participants may request a withdrawal from their
     account for certain hardships that result from medical expenses, expenses
     to purchase a principal residence, or tuition expense for the next 12
     months of post secondary education for the participant, their spouse,
     children or dependents.  The Committee for the Administration of the
     Employee Participation and Savings Plan of Millipore Corporation determines
     the existence of hardship.  Participation Account contributions and income
     earned may be transferred to the Retirement Plan for distribution in
     accordance with its provisions, upon meeting certain requirements as
     outlined in the Plan document.

     Administrative Expenses
     -----------------------

     Generally, Plan administration expenses are paid by the Company; however,
     certain expenses related to recordkeeping and investment activities charged
     by the Plan's custodian are paid by the Plan.  The plan administrator is
     the Company.


B.   Summary of Significant Accounting Policies
     ------------------------------------------

     Basis of Accounting
     -------------------

     The Plan's financial statements are prepared under the accrual basis of
     accounting.

     Investment Valuation
     --------------------

     Investments in the money market fund are valued at cost, which approximates
     fair market value.  Investments in mutual funds are valued at their net
     asset value, representing the value of which shares of the fund may be
     purchased or redeemed. Common stocks are valued at the last reported sales
     price on the last business day of the year.  Participant loans are valued
     at principal plus accrued interest, which approximates fair value.  The
     investment in insurance contracts is valued at contract value.

     Purchases and sales of investments are recorded on a trade date basis.

     Net appreciation (depreciation) on fair value of investments includes
     realized gains and losses and unrealized appreciation (depreciation) on
     investments.  In determining the net gain or loss on investments, cost is
     determined on the average cost basis.

                                       6


                             MILLIPORE CORPORATION
                   EMPLOYEES' PARTICIPATION AND SAVINGS PLAN

                         Notes to Financial Statements

B.   Summary of Significant Accounting Policies - (continued)
     --------------------------------------------------------

     Use of Estimates
     ----------------

     The preparation of the financial statements in conformity with generally
     accepted accounting principles requires the Trustees to make significant
     estimates and assumptions that affect the reported amounts of assets
     available for plan benefits and disclosure of contingent assets and
     liabilities at the date of the financial statements and the changes in
     assets available for plan benefits during the reporting period. Actual
     results could differ from those estimates.

     Risks and Uncertainties
     -----------------------

     The Plan provides for various investment options in any combination of
     stocks, bonds, fixed income securities, mutual funds, money market funds,
     and other investment securities.  Investment securities are exposed to
     various risks such as interest rate, market, and credit risks.  Due to the
     level of risk associated with certain investment securities, and a level of
     uncertainty related to changes in the value of investment securities, it is
     at least reasonably possible that changes in risks in the near term could
     materially affect participants' account balances, the amounts reported in
     the statement of assets available for plan benefits, and the statement of
     changes in assets available for plan benefits.

     Investment Income
     -----------------

     Dividend income is recorded on the ex-dividend date.  Interest income is
     recorded on an accrual basis.

     Contributions
     -------------

     Contributions from the Company under the Participation Account are accrued
     and paid annually based upon a determination by the Board of Directors of
     the Company in accordance with the provisions of the Plan.

     Payment of Benefits
     -------------------

     Benefits payments are recorded when paid.

     Related Party Transactions
     --------------------------

     Certain plan investments are shares of mutual funds managed by T. Rowe
     Price.  T. Rowe Price is the trustee as defined by the Plan and, therefore,
     these transactions qualify as party-in-interest transactions.

     The Plan invests in common stock of Millipore Corporation, the employer,
     and transactions in this common stock are party-in-interest transactions.

     Reclassifications
     -----------------

     Certain prior year information in the financial statements has been
     reclassified to the current year presentation.

                                       7



                             MILLIPORE CORPORATION
                   EMPLOYEES' PARTICIPATION AND SAVINGS PLAN

                         Notes to Financial Statements


C.   Investments
     -----------

     The following table presents the fair value of the Plan's investments as of
     December 31:

                                                       2000           1999
                                                   ------------   -------------

     T. Rowe Price Blue Chip Growth Fund           $ 13,788,486*  $ 12,996,690*
     T. Rowe Price Equity Index Trust                15,807,551*    19,654,715*
     T. Rowe Price Summit Cash Reserves Fund         11,079,136*    12,322,184*
     T. Rowe Price Balanced Fund                     14,237,109*    16,307,737*
     Van Kampen Emerging Growth Fund, Class A        17,168,159*    19,654,715*
     Millipore Common Stock                          18,443,167*    10,777,402*
     GMO US Core Fund III **                         35,665,628*    32,938,437*
     GMO Domestic Bond Fund III **                   29,910,971*    26,266,889*
     Investment in guaranteed insurance contracts       305,570        323,348
     Other mutual funds                              17,484,535     15,829,222
                                                    -----------    -----------

     Total investments at fair value               $173,890,312   $167,071,339
                                                   ============   ============

     *  Investments that represent 5% or more of the Plan's assets at the end of
        the year.
     ** Non-participant directed investments

     During the year ended December 31, 2000, the Plan's investments (including
     gains and losses on investments bought and sold, as well as held during the
     year) appreciated (depreciated) in value as follows:

         Mutual Funds          $ (6,958,175)
         Common Stock             7,293,216
                               ------------
         Net appreciation      $    335,041
                               ============

D.   Non-Participant Directed Investments
     ------------------------------------

     Information about the assets and the significant components of the changes
     in assets relating to the non-participant directed investments, the
     Participation Account, is as follows:

                                                          December 31,
                                                     2000             1999
                                                 -----------       -----------
Assets:
     Mutual Funds                                $72,902,449       $73,803,889
                                                 ===========       ===========


                                                 Year Ended        Year Ended
                                                December 31,      December 31,
                                                    2000              1999
                                                ------------      ------------
Change in Assets:
     Contributions                               $ 5,615,169      $ 5,016,613
     Earnings                                      5,328,434        5,446,357
     Benefits paid to Participants                (6,248,524)      (5,805,512)
                                                 -----------      -----------
           Change in assets                      $ 4,695,079      $ 4,657,458
                                                 ===========      ===========

                                       8


                             MILLIPORE CORPORATION
                   EMPLOYEES' PARTICIPATION AND SAVINGS PLAN

                         Notes to Financial Statements

E.   Interest in Master Trust
     -------------------------

     Prior to August 1, 1999, the assets of the Balanced Fund of the Plan and of
     the Retirement Plan were commingled and jointly invested in a Master Trust.
     Subsequent to August 1, 1999, the assets are no longer commingled.

F.   Plan Termination
     ----------------

     While the Company has not expressed any intent to discontinue its
     contribution to the Plan, it is free to do so at any time under the current
     provisions of the Plan.  In the event of a permanent discontinuance of
     Company contributions to the Plan, dissolution of the Company, acquisition
     of the Company by an unaffiliated Company or vote by the Company's Board of
     Directors to discontinue the Plan, the Plan shall be deemed terminated and
     each participant shall be entitled to an immediate distribution of their
     account.

G.   Tax Status
     ----------

     No provision for income taxes has been included in the Plan's financial
     statements, as the Plan qualifies as a tax-exempt entity under section 401
     of the Internal Revenue Code (IRC).  The Internal Revenue Service has
     determined and informed the Company by a letter dated May 15, 2000, that
     the Plan is designed in accordance with applicable sections of the IRC.  To
     the best of its knowledge, the plan administrator believes that the Plan is
     currently in compliance with its terms.

H.   Subsequent Event
     ----------------

     Effective April 1, 2001 employees of Mykrolis Corporation, a subsidiary of
     Millipore Corporation, are no longer eligible employees under the Millipore
     Corporation Employees' Participation and Savings Plan.  All participants
     who were employed in the microelectronics division of the Company and whose
     employment is transferred to Mykrolis Corporation shall cease active
     participation in the Plan as of April 1, 2001.  The total accounts of the
     microelectronics employees and the promissory notes representing any
     outstanding loans to such employees shall be transferred to the Mykrolis
     Corporation Savings and Investment Plan.

                                       9


                             MILLIPORE CORPORATION
                   EMPLOYEES' PARTICIPATION AND SAVINGS PLAN

       Schedule H, line 4i: Schedule of Assets Held at December 31, 2000

                                                Units/Maturity Date
Security Description                            and interest rate    Fair Value
- --------------------                            -------------------  ----------

*  T. Rowe Price Blue Chip Growth Fund                    407,340   $ 13,788,486
*  T. Rowe Price Equity Index Trust                       451,257     15,807,551
*  T. Rowe Price Summit Cash Reserves Fund             11,079,136     11,079,136
*  T. Rowe Price Balanced Fund                            742,676     14,237,109
   Deutsche International Equity Fund                     133,184      3,370,900
   Van Kampen Emerging Growth Fund, Class A               273,465     17,168,159
   Robertson Stephens (RS) Emerging Growth Fund           139,802      6,152,689
   Pimco Total Return Fund                                 51,702        537,192
*  Millipore Common Stock                                 292,748     18,443,167
   Investment in insurance contract                1/1/2001; 5.75%       189,171
   Investment in insurance contract                1/1/2002; 6.10%       116,399
   GMO US Core Fund III**                               6,063,498     35,665,628
   GMO Domestic Bond Fund III**                         3,074,098     29,910,971
   GMO Small Cap Value Fund III**                         531,397      7,423,754
                                                                    ------------
Total investments                                                   $173,890,312
                                                                    ============

     *  Denotes party-in-interest
     ** Denotes non-participant directed investment.  Cost information, which
        is required, was not available.

                                      10


                      CONSENT OF INDEPENDENT ACCOUNTANTS
                      ----------------------------------


We hereby consent to the incorporation by reference in the Registration
Statement on Form S-8 (No.2-85698) of Millipore Corporation of our report dated
June 8, 2001, relating to the financial statements of Millipore Corporation
Employees' Participation and Savings Plan, which appears in this Form 11-K.


PricewaterhouseCoopers LLP



Boston, Massachusetts
June 8, 2001