Exhibit 10.4

                              EMPLOYMENT AGREEMENT


         THIS EMPLOYMENT AGREEMENT (the "Agreement"), made as of the 1/st/ day
of August, 2002, is entered into by and between Curis, Inc., a Delaware
corporation (the "Company"), and Christopher U. Missling (the "Employee").

         The Company desires to employ the Employee, and the Employee desires to
be employed by the Company. In consideration of the mutual covenants and
promises contained herein, and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties hereto
agree as follows:

         1.    Term of Employment. The Company hereby agrees to employ the
               Employee, and the Employee hereby accepts employment with the
               Company, upon the terms set forth in this Agreement, for the
               period commencing on August 1, 2002 (the "Commencement Date") and
               ending on July 31, 2006 (such period, as it may be extended, the
               "Employment Period"), unless sooner terminated in accordance with
               the provisions of Section 4.

         2.    Position.

               (ii)    The Employee shall serve as Senior Vice President,
                       Finance and Strategic Planning and Chief Financial
                       Officer of the Company. The Employee shall have duties
                       and authority consistent with his position as Senior Vice
                       President, Finance and Strategic Planning and Chief
                       Financial Officer and as may be assigned from time to
                       time by the President and Chief Executive Officer (the
                       "President") and the Board of Directors of the Company
                       (the "Board").


                       The Employee shall report to, and be subject to the
                       supervision of, the President and the Board. The Employee
                       agrees to devote his



                       entire business time to the business and interests of the
                       Company during the Employment Period.

                (iii)  The Employee agrees to abide by the rules, regulations,
                       instructions, personnel practices and policies of the
                       Company and any changes therein which may be adopted from
                       time to time by the Company.

            3.  Compensation and Benefits.

                3.1    Salary. The Company shall pay the Employee, in periodic
                       installments in accordance with the Company's customary
                       payroll practices, a base salary of $225,000 per annum.
                       Such salary shall be subject to annual review by the
                       President and the Board.

                3.2    Bonus. The Employee's annual bonus shall be determined by
                       the President and the Board and shall be based on the
                       achievement of specific objectives established by the
                       President and the Board. Such bonus shall be paid in the
                       form of cash or additional shares of common stock of the
                       Company (or options therefore), at the President's and
                       Board's discretion.

                3.3    Fringe Benefits. The Employee shall be entitled to
                       participate in all medical and other benefit programs
                       that the Company establishes and makes available to its
                       employees, if any, to the extent that Employee's
                       position, tenure, salary, age, health and other
                       qualifications make him eligible to participate. The
                       Employee shall be entitled to four weeks paid vacation
                       per year.

                       The Company will provide parking or reimbursement of the
                       cost of a MBTA pass.

                       The Company will provide fully paid D & O insurance
                       coverage for Employee

                3.4    Stock Options. The Company will grant Employee an option
                       to purchase 200,000 shares of common stock of the
                       Company, subject to approval by the Board of Directors at
                       the first board meeting after August 1, 2002. The stock
                       option will vest over four (4)



        years with 25% vesting on Employee's anniversary of employment. The
        stock option will then vest at 6.25% per quarter over the remainder of
        the vesting period. Vesting of stock options is contingent upon
        Employee's continued employment with the Company. In the case of a
        Change of Control, even though no job of equal or comparable title and
        function is offered to Employee, all remaining options shall vest. The
        exercise price of the option will be fair market value as established by
        the Board of Directors. The determination of the exercise price shall be
        consistent with the policy of the Compensation Committee. The stock
        option will be evidence by an Option Agreement and will be subject to
        all the terms and provisions of the Option Agreement and the Plan.
        Employee will be granted an additional option to purchase 150,000 shares
        of common stock of the Company subject to approval by the Board of
        Directors at the next board meeting after August 1, 2002. The stock
        option will vest upon achievement of goals identified by the board and
        will be treated as a variable option and therefore subject to variable
        accounting. The exercise price of the option will be fair market value
        as established by the Board of Directors. The stock option will be
        evidenced by an Option Agreement and will be the subject to all the
        terms and provision of the Option Agreement Plan.

   3.5  Reimbursement of Expenses. The Company shall reimburse the Employee for
        all reasonable travel, entertainment and other expenses incurred or paid
        by the Employee in connection with, or related to, the performance of
        his duties, responsibilities or services under this Agreement, upon
        presentation by the Employee of documentation, expense statements,
        receipts, vouchers and/or such other supporting information as the
        Company may request, provided, however, that the maximum amount
        available for such



                                    travel, entertainment and other expenses may
                                    be fixed in advance by the President and the
                                    Board.

                               3.6  Relocation. A condition of Employee's
                                    employment by the Company is relocation of
                                    Employee's residence to the Boston area
                                    within a six months period unless otherwise
                                    mutually agreed. In connection with the
                                    Company shall reimburse Employee for
                                    reasonable expenses incurred in moving his
                                    principal residence to the Boston area.
                                    Eligible relocation includes airfare, car
                                    rental, and temporary housing and commuting
                                    expenses between Germany and the United
                                    States. The Company will refer Employee to a
                                    relocation specialist and moving company to
                                    assist in this process. Employee also shall
                                    be reimbursed the airfare for two overseas
                                    trips. Relocation assistance is taxable
                                    under IRS regulations and will be included
                                    in your W-2. Employee will receive a tax
                                    gross-up payment in an amount that after all
                                    Federal, state and local income taxes
                                    thereon shall equal the receipt of such
                                    reimbursement under this section.

                                    The Company agrees that Employee may stay in
                                    Germany during the first six months of the
                                    employment. The Company will reimburse
                                    airfare, car rental, and temporary housing
                                    and commuting expenses between Germany and
                                    the United States. The Company will pay
                                    reasonable costs of preparation of
                                    Employee's annual and estimated federal
                                    income tax {Massachusetts, State and
                                    Germany} and income tax returns for proper
                                    compliance with double taxation treaty.

                               3.7  Withholding. All salary and other
                                    compensation payable to the Employee shall
                                    be subject to applicable withholdings.

                 4.  Termination of Employment Period.

                            (a)  The employment of the Employee by the Company
                 pursuant to this Agreement shall terminate upon the expiration
                 of the Employment Period.

                            (b)  The Company has the right to terminate the
                 Employee's employment



under this Agreement, by notice to the Employee in writing at any time (i) for
Cause (as defined below), (ii) without Cause for any or no reason, or (iii) due
to the Disability (as defined below) of the Employee. Any such termination shall
be effective upon the date of such notice to the Employee or such other date as
may be specified in such notice.

          (c) Employee's employment under this Agreement shall terminate
immediately upon the Employee's death.

          (d) The Employee shall have the right to terminate his employment
under this Agreement (i) for any reason or no reason upon sixty (60) days' prior
written notice to the Company or (ii) for Good Reason (as defined below) upon
thirty (30) days' prior written notice specifying such Good Reason.

          (e) As used in this Agreement, the terms below shall have the
following meanings:

              (i)   "Cause" shall mean (a) a good faith finding by the Company
that (i) the Employee has breached this Agreement and has failed to remedy such
failure within thirty (30) days after notice thereof to the Employee, or (ii)
the Employee has engaged in dishonesty, gross negligence or misconduct, or
(b) the conviction of the Employee of, or the entry of a pleading of guilty or
nolo contendere by the Employee to, any crime involving moral turpitude or any
felony.

              (ii)  "Good Reason" shall mean (a) any significant diminution in
the Employee's position, duties, power or title; (b) any reduction in his annual
base salary; (c) any material breach by the Company of this Agreement which is
not cured within thirty (30) days after notice of such breach by the Employee
to the Company; or (d) the failure of the Company to obtain a reasonably
satisfactory agreement from any successor to the business of the Company to
assume and agree to perform this Agreement, as contemplated by Section 10 below.

              (iii) "Disability" shall be deemed to occur if, as a result of the
Employee's incapacity due to physical or mental illness, the Employee shall have
been absent from the full-time performance of his duties with the Company for
six (6) consecutive months.



     5.   Immigration. The Company shall process the request for Employee's Visa
(H-1B) and for Green Card status. All costs including, but not limited to filing
fees, legal fees, travelling and other expenses shall be either paid or
reimbursed by the Company.

     6.   Compensation upon Termination.

          (a)  If the Employment Period is terminated (i) by the Company without
Cause, or (ii) by the Employee for Good Reason, then the Company shall (A) pay
to the Employee his base salary accrued through the date of termination, and (B)
pay to the Employee, or his estate, in equal bi-weekly installments over a
six-month period following such termination, a severance amount equal to six
months of his base salary as in effect as the time of termination.

          (b)  If the Employment Period is terminated (i) by the Company for
Cause, (ii) by the Employee without Good Reason or (iii) due to the death or
Disability of the Employee, the Company shall pay to the Employee his base
salary accrued through the date of termination.

          (c)  The Employee shall not be required to mitigate the amount of any
payment provided for in this Section 5 by seeking other employment or otherwise.

     7.   Notices. All notices, instructions, demands, claims, requests and
other communications given hereunder or in connection herewith shall be in
writing. Any such communication shall be sent either (a) by registered or
certified mail, return receipt requested, postage prepaid, or (b) via a
reputable nationwide overnight courier service, in each case to the address set
forth below. Any such communication shall be deemed to have been delivered two
business days after it is sent by registered or certified mail, return receipt
requested, postage prepaid, or one business day after it is sent via a reputable
nationwide overnight courier service.

                             To the Company:  Curis, Inc.
                                              61 Moulton Street
                                              Cambridge, Massachusetts 02138
                                              Fascimile: (617) 503-6501
                                              Attention: Chief Executive Officer



                    To the Employee:    Christopher U. Missling

Either party hereto may give any notice, instruction, demand, claim, request or
other communication hereunder using any other means (including personal
delivery, expedited courier, messenger service, telecopy, telex, ordinary mail
or electronic mail), but no such communication shall be deemed to have been duly
given unless and until it actually is received by the party for which it is
intended. Either party hereto may change the address to which notices,
instructions, demands, claims, requests and other communications hereunder are
to be delivered by giving the other party hereto notice in the manner set forth
in this Section 6.

     8.   Entire Agreement. This Agreement constitutes the entire agreement
between the parties and supersedes all prior agreements and understandings,
whether written or oral, relating to the subject matter of this Agreement.

     9.   Amendment. This Agreement may be amended or modified only by a written
instrument executed by both the Company and the Employee.

     10.  Governing Law. This Agreement shall be construed, interpreted and
enforced in accordance with the laws of the Commonwealth of Massachusetts.

     11.  Successors and Assigns. The Company will require any successor
(whether direct or indirect, by purchase, merger, consolidation or otherwise) to
all or substantially all of the business or assets of the Company expressly to
assume and agree to perform this Agreement to the same extent that the Company
would be required to perform it if no such succession had taken place. As used
in this Agreement, "Company" shall mean the Company as defined above and any
successor to its business or assets which assumes and agrees to perform this
Agreement by operation of law, or otherwise.

     12.  Miscellaneous.

          12.1 No delay or omission by the Company in exercising any right under
this Agreement shall operate as a waiver of that or any other right. A waiver
or consent given by the Company on any one occasion shall be effective only in
that instance and shall not be construed as a bar or waiver of any right on any
other occasion.

          12.2 The captions of the sections of this Agreement are for
 convenience



     of reference only and in no way define, limit or affect the scope or
     substance of any section of this Agreement.

          12.3 In case any provision of this Agreement shall be invalid, illegal
     or otherwise unenforceable, the validity, legality and enforceability of
     the remaining provisions shall in no way be affected or impaired thereby.

          IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
     of the day and year set forth above.

                                    CURIS, INC.


                                    By: /s/ Daniel R. Passeri
                                        ---------------------
                                    Name: Daniel R. Passeri
                                    Title: President and Chief Executive Officer


                                    EMPLOYEE


                                    /s/ Christopher U. Missling
                                    ---------------------------
                                      Christopher U. Missling