EXHIBIT 10.1

MYRIAD GENETICS, INC. HAS OMITTED FROM THIS EXHIBIT 10.1 PORTIONS OF THE
AGREEMENT FOR WHICH MYRIAD GENETICS, INC. HAS REQUESTED CONFIDENTIAL TREATMENT
FROM THE SECURITIES AND EXCHANGE COMMISSION. THE PORTIONS OF THE AGREEMENT FOR
WHICH CONFIDENTIAL TREATMENT HAS BEEN REQUESTED ARE MARKED "[ ]" AND SUCH
CONFIDENTIAL PORTIONS HAVE BEEN FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION.

                    PATENT AND TECHNOLOGY LICENSE AGREEMENT

THIS  fourteen   (14) page AGREEMENT ("AGREEMENT") is made on this 2nd day
     -----------                                                               
of December, 1996  by and between the BOARD OF REGENTS ("BOARD") of THE
UNIVERSITY OF TEXAS SYSTEM ("SYSTEM"), an agency of the State of Texas, whose
address is 201 West 7th Street, Austin, Texas  78701, THE UNIVERSITY OF TEXAS
M. D. ANDERSON CANCER CENTER ("MDA"), a component Institution of the SYSTEM and
Myriad Genetics, Inc., a Delaware corporation having a principal place of
business located at 390 Wakara Way, Salt Lake City, Utah 84108 ("LICENSEE").

 
                              TABLE OF CONTENTS 
        RECITALS                                         Page 2
                                                       
I.      EFFECTIVE DATE                                    Page 2
                                                       
II.     DEFINITIONS                                       Page 2
                                                       
III.    LICENSE                                           Page 3
                                                       
IV.     CONSIDERATION, PAYMENTS AND REPORTS               Page 4
                                                       
V.      PUBLICATION                                       Page 6
                                                       
VI.     PATENTS AND INVENTIONS                            Page 7
                                                       
VII.    INFRINGEMENT BY THIRD PARTIES                     Page 7
                                                       
VIII.   PATENT MARKING                                    Page 8
                                                       
IX.     INDEMNIFICATION                                   Page 8
                                                       
X.      USE OF BOARD AND COMPONENT'S NAME                 Page 8
                                                       
XI.     CONFIDENTIAL INFORMATION                          Page 9
                                                       
XII.    ASSIGNMENT                                        Page 9
                                                       
XIII.   TERMS AND TERMINATION                             Page 9
                                                       
XIV.    WARRANTY:  SUPERIOR-RIGHTS                        Page 11
                                                       
XV.     GENERAL                                           Page 12
                                                       
        SIGNATURES                                        Page 13

        EXHIBIT I                                         Page 14

                                       1

 
                                    RECITALS

A.  BOARD owns certain TECHNOLOGY RIGHTS related to LICENSED SUBJECT MATTER,
    which were developed at MDA, a component institution of SYSTEM.

B.  BOARD desires to have the LICENSED SUBJECT MATTER developed in the LICENSED
    FIELD and used for the benefit of LICENSEE, BOARD, SYSTEM, MDA, the
    inventor, and the public as outlined in the Intellectual Property Policy
    promulgated by the BOARD.

C.  LICENSEE wishes to obtain a license from BOARD to practice LICENSED SUBJECT
    MATTER.

NOW, THEREFORE, IN CONSIDERATION OF THE MUTUAL COVENANTS AND PREMISES HEREIN
CONTAINED, THE PARTIES HERETO AGREE AS FOLLOWS:

                               I.  EFFECTIVE DATE

1.1  Subject to approval by BOARD, this AGREEMENT shall be effective as of the
     date written herein above ("EFFECTIVE DATE").

                                II.  DEFINITIONS

As used in this AGREEMENT, the following terms shall have the meanings
indicated:

2.1  AFFILIATE shall mean any business entity more than 50% owned by LICENSEE,
     any business entity which owns more than 50% of LICENSEE, or any business
     entity that is more than 50% owned by a business entity that owns more than
     50% of LICENSEE.

2.2  LICENSED FIELD shall mean all human and animal diagnostic, preventive and
     therapeutic applications within the LICENSED SUBJECT MATTER.

2.3  LICENSED PRODUCTS shall mean any product or service SOLD by LICENSEE
     comprising or making use of LICENSED SUBJECT MATTER pursuant to this
     AGREEMENT.

2.4  LICENSED SUBJECT MATTER shall mean inventions and discoveries defined
     herein as PATENT RIGHTS or as TECHNOLOGY RIGHTS.

2.5  LICENSED TERRITORY shall mean the entire world.

                                       2

 
2.6  NET SALES shall mean the gross  amounts invoiced by LICENSEE from the SALE
     of LICENSED PRODUCTS less sales discounts actually granted in amounts
     customary in the trade, including but not limited to pharmacy incentive
     programs and all other similar sales incentive programs, all governmental
     and healthcare rebates, hospital performance incentive program rebates or
     charge backs, sales and/or use taxes actually paid, import and/or export
     duties actually paid, outbound transportation actually prepaid or allowed,
     insurance and postage, amounts actually allowed or credited due to returns
     (not exceeding the original billing or invoice amount) and any
     uncollectable amounts owed to LICENSEE from SALES of LICENSED PRODUCTS.

2.7  PATENT RIGHTS shall only mean any and all of BOARD'S rights in information
     or discoveries claimed in invention disclosures, patents, and/or patent
     applications, whether domestic or foreign, and all divisionals,
     substitutions, renewals, continuations, continuations-in-part, reissues,
     reexaminations or extensions thereof, and any letters patent that issue
     thereon as  set forth in Exhibit I hereto,subject to the limitations, if
     any, set forth therein.

2.8  SALE or SOLD shall mean the transfer or disposition of a LICENSED PRODUCT
     for value to a party other than LICENSEE or an AFFILIATE.

2.9  Subject to the limitations, if any, set forth in Exhibit I hereto,
     TECHNOLOGY RIGHTS shall mean BOARD'S rights in any technical information,
     know-how, process, procedure, composition, device, method, formula,
     protocol, technique, software, design, drawing or data created by the
     inventors listed in Exhibit I hereto and relating to the subject matter of
     PATENT RIGHTS  which is not claimed in PATENT RIGHTS but which is necessary
     for practicing PATENT RIGHTS.

                                 III.  LICENSE

3.1  BOARD, through MDA,  hereby grants to LICENSEE a royalty-bearing, exclusive
     license under LICENSED SUBJECT MATTER to  make, have made, use and/or sell
     LICENSED PRODUCTS within LICENSED TERRITORY for use within LICENSED FIELD
     and, subject to Paragraph 4.5 herein, shall extend to BOARD's undivided
     interest in any LICENSED SUBJECT MATTER developed during the term of this
     AGREEMENT and jointly owned by BOARD and LICENSEE.  This grant shall be
     subject to Paragraph 14.2 and 14.3, hereinbelow , the payment by LICENSEE
     to BOARD of all consideration as provided in Paragraph 4.2 of this
     AGREEMENT, and shall be further subject to rights retained by BOARD and MDA
     to:

     (A) Publish the general scientific findings from research related to
         LICENSED SUBJECT MATTER, subject to ARTICLE V herein under; AND

                                       3

 
     (B) Subject to the provisions of ARTICLE XI herein below, use any
         information contained in LICENSED SUBJECT MATTER for  research, 
         teaching, patient care, and other educationally related purposes.

3.2  LICENSEE shall have the right to extend the license granted herein to any
     AFFILIATE provided that such AFFILIATE consents to be bound by all of the
     terms and conditions of this AGREEMENT.

3.3  Subject to the Paragraph 3.4 herein below, LICENSEE shall have the right to
     grant sublicenses under LICENSED SUBJECT MATTER consistent with the terms
     of this AGREEMENT provided that LICENSEE shall be responsible for its
     sublicensees relevant to this AGREEMENT, and for diligently collecting all
     amounts due LICENSEE from subicensees.  In the event a sublicensee pursuant
     hereto becomes bankrupt, insolvent or is placed in the hands of a receiver
     or trustee, LICENSEE, to the extent allowed under applicable law and in a
     timely manner, agrees to use its best reasonable efforts to collect any and
     all consideration owed to LICENSEE and to have the sublicense agreement
     confirmed or rejected by a court of proper jurisdiction.

3.4  LICENSEE agrees to deliver to MDA a true and correct copy of each
     sublicense granted by LICENSEE, and any modification or termination
     thereof, within thirty (30) days after execution, modification, or
     termination.

3.5  Upon termination of this AGREEMENT, BOARD and MDA agree to accept as
     successors to LICENSEE, existing sublicensees in good standing at the date
     of termination provided that such sublicensees consent in writing to be
     bound by all of the terms and conditions of this AGREEMENT.

                    IV.  CONSIDERATION, PAYMENTS AND REPORTS

4.1  In consideration of rights granted by BOARD to LICENSEE under this
     AGREEMENT, LICENSEE agrees to pay MDA the following:

     (A)  All  out-of-pocket expenses incurred by MDA in filing, prosecuting,
          enforcing and maintaining PATENT RIGHTS  licensed hereunder, for so
          long as, and in such countries as, this AGREEMENT remains in effect.
          MDA will invoice LICENSEE upon a quarterly basis for expenses incurred
          by MDA , and the amounts invoiced will be  due and payable by LICENSEE
          within thirty (30) days thereafter; AND

     (B)  A non-refundable prepaid royalty in the amount of [        ]  which
          shall  not reduce the amount of any other payment provided for in this
          ARTICLE IV, and which shall be due and payable within thirty (30) days
          after execution of this agreement by LICENSEE; AND

                                       4

 
     (C)  A running royalty equal to [            ] of LICENSEE's NET SALES of
          LICENSED PRODUCTS in national political jurisdictions in the LICENSED
          TERRITORY where LICENSED SUBJECT MATTER is covered by one (1) or more
          issued patents or pending patent applications. Such royalties shall be
          reduced to [            ] of the rate stated above for LICENSEE'S
          NET SALES of LICENSED PRODUCTS in national political jurisdictions in
          the LICENSED TERRITORY where BOARD and LICENSEE decide not to file
          patent applications and therefore LICENSED SUBJECT MATTER is NOT
          covered by one (1) or more issued patents or pending patent
          applications.

     (D)  [              ] of all consideration (royalties not included)
          other than Research and Development ("R&D") money and direct
          equity investment received by LICENSEE from (i) any sublicensee
          pursuant to Paragraphs 3.3 and 3.4 herein above and (ii) any assignee
          pursuant to Paragraph 12.1 hereinbelow, including but not limited to
          up-front payments, marketing, distribution, franchise, option,
          license, or documentation fees, bonus and milestone payments, plus[
                       ] of NET SALES of LICENSED PRODUCTS of sublicensee and
          LICENSEE (if applicable), all payable within  thirty (30) days after
          March 31, June 30, September 30, and December 31 of each year during
          the term of this AGREEMENT, at which time LICENSEE shall also deliver
          to BOARD and MDA a true and accurate report, giving such particulars
          of the business conducted by LICENSEE and its sublicensees, if any
          exist, during the preceding three (3) calendar months under this
          AGREEMENT as necessary for BOARD to  account for LICENSEE's payments
          hereunder.  Such report shall include all pertinent data, including,
          but not limited to: (a) the total quantities of LICENSED PRODUCTS
          produced; (b) the total SALES, (c) the calculation of royalties
          thereon; (d) the total royalties (or minimum royalties) so computed
          and due MDA; and (e) all other amounts due MDA herein.  Simultaneously
          with the delivery of each such report, LICENSEE shall pay to MDA the
          amount, if any, due for the period of such report.  If no payments are
          due, it shall be so reported.  Should LICENSEE be obligated to pay
          running royalties to third parties to avoid infringing such third
          parties' patent rights which otherwise because of infringement would
          preclude LICENSEE from practicing LICENSED SUBJECT MATTER, LICENSEE
          may reduce the running royalty due MDA by such running royalties to
          such third parties, provided, however, the running royalty due MDA
          shall in no case be less than one-half the rates stated herein.

                                       5

 
4.2  As further consideration to BOARD and MDA, LICENSEE at its sole cost and
     expense agrees to use its reasonable commercial efforts to:
     (a)  isolate the [                   ] on [                    ]. 
     (b)  identify mutations of said gene.


4.3  During the Term of this AGREEMENT and for one (1) year thereafter, LICENSEE
     shall keep complete and accurate records of its and its sublicensees' SALES
     and NET SALES of LICENSED PRODUCTS to enable the royalties payable
     hereunder to be determined.  LICENSEE shall permit MDA or its
     representatives, at MDA's expense, to periodically examine its books,
     ledgers, and records once annually during regular business hours and with
     reasonable advanced notice for the purpose of and to the extent necessary
     to verify any report required under this AGREEMENT.  In the event that the
     amounts due to MDA are determined to have been underpaid in an amount equal
     to or greater than five percent (5%) of the total amount due during the
     period of time so examined, LICENSEE shall pay the cost of such
     examination, and accrued interest at the highest allowable rate.

4.4  Upon the request of MDA but not more often than once per calendar year,
     LICENSEE shall deliver to MDA a written report as to LICENSEE'S (and
     sublicensees') efforts and accomplishments during the preceding year in
     diligently commercializing LICENSED SUBJECT MATTER in the LICENSED
     TERRITORY and LICENSEE'S (and sublicensees') commercialization plans for
     the upcoming year.

4.5  All amounts payable hereunder by LICENSEE shall be payable in United States
     funds without deductions for taxes, assessments, fees, or charges of any
     kind.  Checks shall be made payable to The University of Texas M. D.
     Anderson Cancer Center and mailed by U.S. Mail to Box 297402, Houston,
     Texas 77297 Attention: Manager,  Sponsored Programs.

4.6  No payments due or royalty rates under this AGREEMENT shall be reduced as
     the result of co-ownership of LICENSED SUBJECT MATTER by BOARD and another
     party, including LICENSEE.

                                V.  PUBLICATION

5.1  MDA shall have the right to publish the general scientific findings related
     to the LICENSED SUBJECT MATTER, provided such pubication, presentation or
     public disclosure is submitted to LICENSEE at least sixty (60) days prior
     to submitting it to a journal, editor, or other third party. LICENSEE shall
     have sixty (60) days after receipt to review the proposed publication,
     presentation or public disclosure.

                                       6

 
                          VI.  PATENTS AND INVENTIONS

6.1 It is agreed by LICENSEE and MDA that in the event an invention, whether
    patentable or not, is made solely by LICENSEE or jointly by LICENSEE and MDA
    under the Article 4.2 hereof, LICENSEE shall assign all its right, title and
    interest in said invention  to MDA, and  MDA shall be the sole owner of such
    invention.  If after consultation with LICENSEE it is agreed by MDA and
    LICENSEE that a new patent application should be filed for LICENSED SUBJECT
    MATTER, MDA will prepare and file appropriate patent applications, and
    LICENSEE will pay the cost of searching, preparing, filing, prosecuting and
    maintaining same.  If LICENSEE notifies MDA that it does not intend to pay
    the cost of an application, or the prosecution or maintenance thereof in a
    national political jurisdiction, then MDA may file, prosecute or maintain
    such application at its own expense and LICENSEE shall have no rights to
    such patent application or patent in that national ploitical jurisdiction.
    MDA shall provide LICENSEE with a copy of the application for which LICENSEE
    has paid the cost of filing, as well as copies of any documents received or
    filed during prosecution thereof.

                      VII.  INFRINGEMENT BY THIRD PARTIES

7.1 LICENSEE shall have the obligation of enforcing at its expense any patent
    exclusively licensed hereunder against infringement by third parties and
    shall be entitled to retain recovery from such enforcement.  LICENSEE shall
    pay MDA  a royalty on any monetary recovery to the extent that such monetary
    recovery by LICENSEE is held to be damages or a reasonable royalty in lieu
    thereof.  In the event that LICENSEE does not file suit against a
    substantial infringer of such patents within six (6) months of knowledge
    thereof, then BOARD and MDA shall have the right to enforce any patent
    licensed hereunder on behalf of itself and LICENSEE, with MDA  retaining all
    recoveries from such enforcement.

7.2 In any suit or dispute involving an infringer, the parties shall cooperate
    fully, and upon the request and at the expense of the party bringing suit,
    the other party shall make available to the party bringing suit at
    reasonable times and under appropriate conditions all relevant personnel,
    records, papers, information, samples, specimens, and the like which are in
    its possession.

7.3 In the event that an action for infringment is brought against LICENSEE,
    its AFFILIATES or sublicensees by a third party because of manufacture, use
    or sale of LICENSED PRODUCTS, LICENSEE shall defend, at its own cost, any
    such third party claim or action.  MDA shall cooperate fully in such defense
    and furnish to LICENSEE all evidence and assistance.

                                       7

 
                             VIII.  PATENT MARKING

 8.1 LICENSEE agrees that all packaging containing individual LICENSED
     PRODUCT(S), and documentation therefor, sold by LICENSEE, SUBSIDIARIES, and
     sublicensees of LICENSEE will be marked permanently and legibly with the
     number of the applicable patent(s) licensed hereunder in accordance with
     each country's patent laws, including Title 35, United States Code.

                              IX.  INDEMNIFICATION

 9.1 LICENSEE shall hold harmless and indemnify BOARD, SYSTEM, MDA, its Regents,
     officers, employees, students, and agents from and against any claims,
     demand, or causes of action whatsoever, costs of suit and reasonable
     attorney's fees including without limitation those costs arising on account
     of any injury or death of persons or damage to property caused by, or
     arising out of, or resulting from, the exercise or practice of the license
     granted hereunder by LICENSEE or its officers, employees, agents or
     representatives.


                     X.  USE OF BOARD AND COMPONENT'S NAME

10.1 LICENSEE shall not use the name of (or the name of any employee of) MDA,
     SYSTEM or BOARD without the advance, express written consent of BOARD
     secured through:

               The University of Texas
               M. D. Anderson Cancer Center
               Office of Public Affairs
               1515 Holcombe Boulevard
               Box 229
               Houston, Texas  77030
               ATTENTION:  Stephen C. Stuyck

                                       8

 
                         XI.  CONFIDENTIAL INFORMATION

11.1 MDA and LICENSEE each agree that all information contained in documents
     marked "confidential" which are forwarded to one by the other shall be
     received in strict confidence, used only for the purposes of this
     AGREEMENT, and not disclosed by the recipient party (except as required by
     law or court order), its agents or employees without the prior written
     consent of the other party, unless such information (a) was in the public
     domain at the time of disclosure, (b) later became part of the public
     domain through no act or omission of the recipient party, its employees,
     agents, successors or assigns, (c) was lawfully disclosed to the recipient
     party by a third party having the right to disclose it, (d) was already
     known by the recipient party at the time of disclosure, (e) was
     independently developed or (f) is required to be submitted to a government
     agency pursuant to any preexisting obligation.

11.2 MDA's and LICENSEE's obligation of confidence hereunder shall be fulfilled
     by using the same degree of care with the other party's confidential
     information as it uses to protect its own confidential information.  This
     obligation shall exist while this AGREEMENT is in force and for a period of
     three (3) years thereafter.


                               XII.  ASSIGNMENT

12.1 Except in connection with merger, consolidation or sale of substantially
     all of LICENSEE's assets to a third party this AGREEMENT may not be
     assigned by LICENSEE without the prior written consent of BOARD.
 

                          XIII.  TERMS AND TERMINATION

13.1 Subject to Articles 13.2, 13.3 and 13.4 hereinbelow, the term of this
     AGREEMENT shall extend from the Effective Date set forth hereinabove to (i)
     the full end of the term or terms for which PATENT RIGHTS have not expired,
     or (ii)d if only TECHNOLOGY RIGHTS are licensed and no PATENT RIGHTS are
     applicable, for a term of fifteen (15) years.

                                       9

 
13.2 BOARD and MDA shall have the right at any time after one (1)   year from
     the EFFECTIVE DATE of this AGREEMENT to terminate the license granted
     herein in any national political jurisdiction within the LICENSED TERRITORY
     if LICENSEE, within ninety (90) days after written notice from MDA of such
     intended termination, fails to provide written evidence satisfactory to MDA
     that LICENSEE has commercialized or is actively and effectively attempting
     to commercialize an invention licensed hereunder within such
     jurisdiction(s). Accurate, written evidence provided by LICENSEE to MDA
     within said ninety (90) day period that LICENSEE has an effective, ongoing
     and active research, development, manufacturing, marketing, or sales
     program, as appropriate, directed toward obtaining regulatory approval
     and/or production and/or sale of LICENSED PRODUCTS incorporating PATENT
     RIGHTS or incorporating TECHNOLOGY RIGHTS within such jurisdiction shall be
     deemed satisfactory evidence.

13.3 Subject to any rights herein which survive termination, this AGREEMENT will
     earlier terminate in its entirety:

     (A)  automatically if LICENSEE shall become bankrupt or insolvent and/or if
          the business of LICENSEE shall be placed in the hands of a receiver or
          trustee, whether by voluntary act of LICENSEE or otherwise; or

     (B)  (i)  upon thirty (30) days written notice by MDA if LICENSEE shall
          breach or default on the payment obligations of ARTICLE IV, or use of
          name obligations of ARTICLE X; or (ii) upon ninety (90) days written
          notice by MDA if LICENSEE shall breach or default on any other
          obligation under this AGREEMENT; provided, however, LICENSEE may avoid
          such termination if before the end of such thirty (30) or ninety (90)
          day period if LICENSEE provides notice and accurate, written evidence
          satisfactory to  MDA that such breach has been cured and  the manner
          of such cure; or.

     (C)  at any time by mutual written agreement between LICENSEE, MDA and
          BOARD, or without cause upon one hundred eighty (180) days written
          notice by LICENSEE to MDA and, subject to any terms herein which
          survive termination.

                                       10

 
13.4 Upon termination of this AGREEMENT for any cause:

     (A)  nothing herein shall be construed to release either party of any
          obligation matured prior to the effective date of such termination.

     (B)  LICENSEE covenants and agrees to be bound by the provisions of
          ARTICLES IX, X AND XI of this AGREEMENT.

     (C)  LICENSEE may, after the effective date of such termination, sell all
          LICENSED PRODUCTS and parts therefore that it may have on hand at the
          date of termination, provided that LICENSEE pays the earned royalty
          thereon and any other amounts due pursuant to ARTICLE IV of this
          AGREEMENT.

 
                        XIV.  WARRANTY:  SUPERIOR-RIGHTS

14.1 Except for the rights, if any, of the Government of the United States as
     set forth hereinbelow, BOARD represents and warrants its belief that it is
     the owner of the entire right, title, and interest in and to LICENSED
     SUBJECT MATTER, and that it has the sole right to grant licenses
     thereunder, and that it has not knowingly granted licenses thereunder to
     any other entity that would restrict rights granted hereunder except as
     stated herein.

14.2 LICENSEE understands that the LICENSED SUBJECT MATTER may have been
     developed under a funding agreement with the Government of the United
     States of America and, if so, that the Government may have certain rights
     relative thereto. This AGREEMENT is explicitly made subject to the
     Government's rights under any such agreement and any applicable law or
     regulation, including P.L. 96-517 as amended by P.L. 98-620. To the extent
     that there is a conflict between any such agreement, applicable law or
     regulation and this AGREEMENT, the terms of such Government agreement,
     applicable law or regulation shall prevail.

14.3 LICENSEE understands and agrees that BOARD, by this AGREEMENT, makes no
     representation as to the operability or fitness for any use, safety,
     efficacy, approvablity by regulatory authorities, time and cost of
     development, patentability, and/or breadth of the LICENSED SUBJECT MATTER.
     BOARD, by this AGREEMENT, makes no representation as to whether there are
     any patents now held, or which will be held, by others or by BOARD in the
     LICENSED FIELD, nor does BOARD make any representation that the inventions
     contained in PATENT RIGHTS do not infringe any other patents now held or
     that will be held by others or by BOARD.

                                       11

 
14.4 LICENSEE, by execution hereof, acknowledges, covenants and agrees that
     LICENSEE has not been induced in anyway by BOARD, SYSTEM, MDA or employees
     thereof to enter into this Agreement, and further warrants and represents
     that (i) LICENSEE has conducted sufficient due diligence with respect to
     all items and issues pertaining to Article XIV herein and all other matters
     pertaining to this Agreement; and (ii) LICENSEE has adequate knowledge and
     expertise, or has utilized knowledgeable and expert consultants, to
     adequately conduct such due diligence, and agrees to accept all risks
     inherent herein.

                                  XV.  GENERAL

15.1 This AGREEMENT constitutes the entire and only AGREEMENT between the
     parties for LICENSED SUBJECT MATTER and all other prior negotiations,
     representations, agreements and understandings are superseded hereby. No
     agreements altering or supplementing the terms hereof may be made except by
     means of a written document signed by the duly authorized representatives
     of the parties.

15.2 Any notice required by this AGREEMENT shall be given by prepaid, first
     class, certified mail, return receipt requested, and addressed in the case
     of BOARD to:

                              BOARD OF REGENTS
                              The University of Texas System
                              201 West Seventh Street
                              Austin, Texas  78701
                              ATTENTION:  Office of General Counsel

    with copy to:             The University of Texas
                              M.D. Anderson Cancer Center
                              Office of Technology Development
                              1020 Holcombe Boulevard, Suite 1405
                              Houston, Texas 77030
                              ATTENTION:  William J. Doty

    or in the case of 
      LICENSEE to:            Myriad Genetics, Inc.
                              390 Wakara WAy
                              Salk Lake City, Utah 84108
 
                              ATTENTION: President

    or such other address as may be given from time to time under the terms of
    this notice provision.

                                       12

 
15.3 LICENSEE covenants and agrees to comply with all applicable federal, state
     and local laws and regulations in connection with its activities pursuant 
     to this AGREEMENT.

15.4 This AGREEMENT shall be construed and enforced in accordance with the laws
     of the United States of America and of the State of Texas.

15.5 Failure of BOARD to enforce a right under this AGREEMENT shall not act as a
     waiver of that right or the ability to later assert that right relative to
     the particular situation involved.

15.6 Headings included herein are for convenience only and shall not be used to
     construe this AGREEMENT.

15.7 If any provision of this AGREEMENT shall be found by a court to be void,
     invalid or unenforceable, the same shall be reformed to comply with
     applicable law or stricken if not so conformable, so as not to affect the
     validity or enforceability of this AGREEMENT.

IN WITNESS WHEREOF, PARTIES HERETO HAVE CAUSED THEIR DULY AUTHORIZED
REPRESENTATIVES TO EXECUTE THIS AGREEMENT.
 
THE UNIVERSITY OF TEXAS             BOARD OF REGENTS OF THE
M.D. ANDERSON CANCER CENTER         UNIVERSITY OF TEXAS SYSTEM

By /s/ Michael J. Best              By /s/ Ray Farabee 
  -----------------------------       ------------------------------
     Michael J. Best                     Ray Farabee
     Chief Financial Officer             Vice Chancellor and
                                         General Counsel


APPROVED AS TO CONTENT:             APPROVED AS TO FORM:

By /s/ William J. Doty              By /s/ Dudley R. Dobie, Jr.
  -----------------------------       ------------------------------
   William J. Doty                      Dudley R. Dobie, Jr.
   Director, Technology Development     Manager, Intellectual Property


MYRIAD GENETICS, INC.


By /s/ Peter D. Meldrum
  -----------------------------  
     Peter D. Meldrum
     President and CEO

                                       13

 
                                   EXHIBIT I
[
          
                               ]

THE DATA REFERENCED ABOVE IS AGREED TO BE CONFIDENTIAL AND SUBJECT TO THE
CONDITIONS OF ARTICLE XI OF THE AGREEMENT TO WHICH THIS EXHIBIT IS ATTACHED.

                                       14