EXHIBIT 10.5

                                  CONFIRMATION


Date:          October 22, 1997

To:            Myriad Genetics, Inc. ("Party B")

Attention:     Jay Moyes

From:          Swiss Bank Corporation, London Branch ("Party A")

Re:            Equity Option Confirmation
               Reference Number 1265546
_______________________________________________________________________________

The purpose of this communication is to confirm the terms and conditions of the
transaction  (the "Transaction") entered into between us on the Trade Date
specified below.

The definitions and provisions contained in the 1991 ISDA Definitions (as
published by the International Swaps and Derivatives Association, Inc. (formerly
known as the International Swap Dealers Association, Inc.) ("ISDA")) are
incorporated into this Confirmation.  In the event of any inconsistency between
those definitions and provisions and this Confirmation, this Confirmation will
govern.

This Confirmation supplements, forms part of, and is subject to, the ISDA Master
Agreement dated as of October 8, 1997, as amended and supplemented from time to
time (the "Agreement"), between you and Swiss Bank Corporation.  All provisions
contained in the Agreement govern this Confirmation except as expressly modified
below.

The terms of the Transaction to which this Confirmation relates are as follows:
 
Trade Date           :      October 21, 1997
 
Buyer                :      Party A
 
Seller               :      Party B
 
Option Style         :      European Option
 
Option Type          :      Call
 
Shares               :      Common Stock of Myriad Genetics, Inc. 
                            (Symbol: MYGN)

 
Number of Options    :      400,000
 
Contract Multiplier  :      1.00
 
Strike Price         :      USD 40.50
 
Total Premium        :      USD 100,000 and call options written by Party A on
                            400,000 shares of Party B's Common Stock. Premium

Payment Date         :      October 24, 1997
 
Expiration Date      :      December 11 1998, or, if that date is not an
                            Exchange Business Day, the following day that is an
                            Exchange Business Day.
Currency
Business Day         :      Any day on which commercial banks are open for
                            business (including dealings in foreign exchange and
                            foreign currency deposits) in the cities from which
                            and in which a payment is to be made.

Exchange
Business Day         :      A day that is (or but for the occurrence of a Market
                            Disruption Event, would have been) a trading day on
                            the Exchange and the Philadelphia Stock Exchange
                            (other than a day on which trading on any such
                            exchange is scheduled to close prior to its regular
                            weekday closing time, first announced on the day of
                            such closing).

Normal
Trading Day          :      An Exchange Business Day on which no Market
                            Disruption Event has occurred or is continuing.

Market
Disruption Event     :      The occurrence or existence on any Exchange Business
                            Day during the one-half hour period that ends at the
                            close of business of any suspension of or limitation
                            imposed on trading (by reason of movements in price
                            exceeding levels permitted by the relevant exchange
                            or otherwise), provided that any such event is
                            material in the reasonable determination of the
                            Calculation Agent, on: (i) the Exchange in the
                            Shares; or (ii) the Philadelphia Stock Exchange in
                            options contracts on the Shares.

 
Exchange             :      Nasdaq National Market
 
Clearance System
Business Day         :      Any day on which the Clearance System is open for
                            the acceptance and execution of settlement
                            instructions.
 
Clearance System     :      Depository Trust Company, or any successor to or
                            transferee of such clearance system.

Calculation Agent    :      Party A, whose calculations shall be binding absent
                            manifest error.
 
Procedure for Exercise
- ----------------------
 
Exercise Date        :      The Expiration Date.
 
Expiration Time      :      5:00 p.m. local time in New York City.

Automatic Exercise   :      The Transaction will be deemed to be automatically
                            exercised if it is In-the-Money on the Expiration
                            Date, unless (i) the Buyer has notified the Seller
                            (by telephone or in writing) prior to 5:00 p.m.
                            local time in New York City on the Expiration Date
                            that it does not wish to exercise the Transaction;
                            or (ii) the Closing Value cannot be determined on
                            the Expiration Date. If the Transaction is to be
                            cash settled or net share settled, "In-the-Money"
                            means that the Cash Settlement Amount is greater
                            than zero. If the Transaction is to be physically
                            settled, "In-the-Money" means that the Closing Value
                            is greater than the Strike Price. "Closing Value"
                            means the closing price of the Shares, as reported
                            on the Exchange, on the Expiration Date.

Seller's telephone
or facsimile number
for purposes of
giving notice        :      Telephone:  801-584-3633
                            Fax:        801-584-3640
                            Attention:  Jay Moyes

Settlement Terms
- ----------------

Settlement           :      The Transaction will be physically settled;
                            provided, however, that Party B may elect to cash
                            settle or net share

 
                            settle the Transaction by giving notice to Party A
                            no later than 20 Exchange Business Days before the
                            Expiration Date (determined without regard to the
                            parenthetical in the definition of Exchange Business
                            Day) (the date of such notice, the "Election Date").
                            Notwithstanding the foregoing, if on the Initial
                            Date (as defined below) the registration statement
                            referred to in Section 4.1 of the Agreement
                            Regarding Registration Rights and Related
                            Obligations (the "Registration Agreement") attached
                            hereto as Exhibit I has not become effective, the
                            Transaction will be cash settled and the parties
                            shall have no further obligations under the
                            Registration Agreement.

Physical Settlement  :      If the Transaction is to be physically settled:

                            (a)  within three Exchange Business Days after the
                            Election Date, Party A and Party B will enter into
                            the Registration Agreement attached hereto as
                            Exhibit I; and

                            (b)  on the Settlement Date, the Seller shall
                            deliver to the Buyer the number of Shares equal to
                            the number of Options exercised against payment by
                            the Buyer to the Seller of an amount equal to the
                            product of (A) the Strike Price multiplied by (B)
                            the number of Options exercised. Such payment and
                            such delivery will be made through the Clearance
                            System at the accounts specified below, on a
                            delivery versus payment basis.

Cash Settlement      :      If the Transaction is to be cash settled:

                            (a)  within one Currency Business Day after written
                            notice by Party A, Party B will pay to Party A the
                            Prepayment Amount. The "Prepayment Amount" shall be
                            an amount calculated by the Calculation Agent equal
                            to (i) the number of Options to be exercised
                            multiplied by (ii) the result of subtracting the
                            Strike Price from the closing price of the Shares,
                            as reported on the Exchange, on the Election Date.

                            (b)  on the Settlement Date, the following payment
                            shall be made:

                                 (i)   if a Prepayment Amount has been paid by
                                 Party B, then (A) if the Final Payment Amount
                                 is a positive number, Party B shall pay to
                                 Party A an amount equal to the Final Payment
                                 Amount and (B) if the Final Payment Amount is a
                                 negative number,

 
                                 Party A shall pay to Party B an amount equal to
                                 the absolute value of the Final Payment Amount.
                                 The "Final Payment Amount" shall be an amount,
                                 which may be less than zero, calculated by the
                                 Calculation Agent equal to (A) the Cash
                                 Settlement Amount minus (B) the Prepayment
                                 Amount minus (C) the Interest Amount. The "Cash
                                 Settlement Amount" shall be the greater of (A)
                                 zero and (B) an amount calculated by the
                                 Calculation Agent equal to (1) the number of
                                 Options exercised multiplied by (2) the result
                                 of subtracting the Strike Price from the
                                 Reference Price. The "Interest Amount" shall be
                                 an amount calculated by the Calculation Agent
                                 equal to the aggregate sum of the amounts of
                                 interest calculated for each day in the period
                                 from (and including) the date the Prepayment
                                 Amount is received by Party A to (but
                                 excluding) the Settlement Date, determined as
                                 follows: (A) the Prepayment Amount multiplied
                                 by (B) the overnight Federal Funds Rate for
                                 such day as reported in Federal Reserve
                                 Publication H.15-519 divided by (C) 360.

                                 (ii) if a Prepayment Amount has not been paid
                                 by Party B, Party B shall pay to Party A the
                                 Cash Settlement Amount, if any.

Reference Price      :      (a)  If the Valuation Period contains fifteen Normal
                            Trading Days, the Reference Price shall be the
                            arithmetic average of the Share Prices on those
                            fifteen Normal Trading Days.

                            (b) If the Valuation Period does not contain fifteen
                            Normal Trading Days, the Calculation Agent shall
                            determine the Share Price for the Valuation Date and
                            as many Exchange Business Days immediately preceding
                            the Valuation Date as shall be necessary, when such
                            Share Prices are taken together with the Share
                            Prices on all Normal Trading Days occurring within
                            the Valuation Period, to provide fifteen Share
                            Prices, and in such case the Reference Price shall
                            be the arithmetic average of those fifteen Share
                            Prices.

Share Price          :      The closing price of the Shares as reported on the
                            Exchange.

Valuation Period     :      The period from and including the fourteenth
                            Exchange 

 
                            Business Day immediately preceding the Expiration
                            Date (the "Initial Date") to and including the
                            Expiration Date, provided that if any Exchange
                            Business Day in the Valuation Period as so
                            determined, shall not be a Normal Trading Day, the
                            Valuation Period shall be extended so that the
                            Valuation Period includes fifteen Normal Trading
                            Days , but in no event shall the last day of the
                            Valuation Period be later than the fifteenth
                            Exchange Business Day after the Expiration Date, and
                            in no event shall the Valuation Period include any
                            day before the Initial Date.

Valuation Date       :      The last day of the Valuation Period.

Net Share
Settlement           :      If a Transaction is to be net share settled,

                            (a)  within three Exchange Business Days after the
                            Election Date, Party A and Party B will enter into
                            the Registration Agreement attached hereto as
                            Exhibit I; and

                            (b) on the Settlement Date, Party B shall deliver to
                            Party A the number of whole Shares (the "Settlement
                            Shares") equal to (i) the Cash Settlement Amount
                            divided by (ii) the Closing Value, plus cash in lieu
                            of any fractional Shares. If within ten Exchange
                            Business Days after the Settlement Date, Party A
                            resells all or any portion of the Settlement Shares
                            and the net proceeds received by the Party A upon
                            resale of such Shares exceed the Cash Settlement
                            Amount (or if less than all of the Settlement Shares
                            are resold, the applicable pro rata portion of the
                            Cash Settlement Amount), Party A shall promptly
                            refund in cash such difference to Party B. In the
                            event that such net proceeds are less than the Cash
                            Settlement Amount (or if less than all of the
                            Settlement Shares are resold, the applicable pro
                            rata portion of the Cash Settlement Amount), Party B
                            shall pay in cash or additional Shares such
                            difference (the "Make-whole Amount") to Party A
                            promptly after receipt of notice thereof. In the
                            event that Party B elects to pay the Make-whole
                            Amount in additional Shares, Party B shall deliver
                            to Party A the number of whole Shares (the "Make-
                            whole Shares") equal to (i) the Make-whole Amount
                            divided by (ii) the closing price of the Shares as
                            reported on the Exchange on the Exchange Business
                            Day prior to delivery of such Shares. If within ten
                            Exchange Business Days after the delivery of the
                            Make-whole Shares to Party A, Party A resells all or
                            any portion of such Shares and the net

 
                            proceeds received by Party A exceed or are less than
                            the Make-whole Amount (or if less than all of the
                            Make-whole Shares are resold, the applicable pro
                            rata portion of the Make-whole Amount), the
                            provisions set forth above with respect to payment
                            of the Settlement Payment in Shares, including Make-
                            whole requirements, shall apply.

Settlement Date      :      If the Transaction is to be cash settled, the
                            Settlement Date shall be three Currency Business
                            Days after the Valuation Date. If the Transaction is
                            to be physically settled or net share settled, the
                            Settlement Date shall be three Clearance System
                            Business Days after the Exercise Date.

Change in Expiration Date
- -------------------------

Delay of Expiration
Date                 :      At any time prior to fifteen days prior to the date
                            that otherwise would have been the Expiration Date,
                            Party B may notify Party A that it would like to
                            delay the Expiration Date to a date (the
                            "Termination Date") not less than ten Exchange
                            Business Days after the date of such notice and not
                            more than 180 days after the original Expiration
                            Date. Promptly after receipt of such notice, Party A
                            shall notify Party B of the additional amount, if
                            any, required to be paid (the "Settlement Amount")
                            by the Buyer of the Transaction to compensate the
                            Seller of the Transaction for such delay. The
                            Settlement Amount shall be reasonably determined by
                            Party A based upon Party A's then current
                            methodology for pricing options. Within five
                            Exchange Business Days after receipt of notice of
                            the Settlement Amount from Party A, Party B shall
                            notify Party A whether it agrees to the Settlement
                            Amount (the date of such notice, the "Agreement
                            Date"). If Party B agrees to the Settlement Amount
                            (i) the Termination Date shall be deemed to be the
                            Expiration Date for all purposes of this
                            Confirmation; and (ii) the Settlement Amount, which
                            shall be in addition to any payment or delivery, if
                            any, otherwise required to be made under the terms
                            of the Transaction, shall be paid by the Buyer on
                            the third Currency Business Day after the Agreement
                            Date. If Party B does not agree to the Settlement
                            Amount, the Expiration Date shall not be delayed.

Adjustment Events
- -----------------

Adjustments          :      During the life of the Transaction, if any
                            adjustment is made

 
                            by The Options Clearing Corporation or its
                            successors ("OCC") in the terms of outstanding OCC-
                            issued options ("OCC Options") on the Shares which
                            are the subject of the Transactions, an equivalent
                            adjustment shall be made in the terms of the
                            Transaction. Except as provided in the following
                            paragraph and in the "Additional Adjustment
                            Provisions" below, no adjustment shall be made in
                            the terms of the Transaction for any event that does
                            not result in an adjustment to the terms of
                            outstanding OCC Options on the Shares. Without
                            limiting the generality of the foregoing, NO
                            ADJUSTMENT SHALL BE MADE IN THE TERMS OF THE
                            TRANSACTIONS FOR ORDINARY CASH DIVIDENDS ON THE
                            SHARES EXCEPT AS PROVIDED IN THE "ADDITIONAL
                            ADJUSTMENTS" PROVISIONS BELOW.

                            If at any time during the life of the Transaction
                            there shall be no outstanding OCC Options on the
                            Shares, and an event shall occur for which an
                            adjustment might otherwise be made under the By-
                            Laws, Rules, and stated policies of the OCC
                            applicable to the adjustment of OCC Options (the
                            "OCC Adjustment Rules"), the parties shall use their
                            best efforts, applying the principles set forth in
                            the OCC Adjustment Rules, to jointly determine
                            whether to adjust the terms of the Transaction and
                            the nature of any such adjustment.

Additional
Adjustments          :      Notwithstanding the foregoing, if upon the
                            occurrence of the following events during the life
                            of the Transaction no adjustment is required to be
                            made to the terms of the Transaction in accordance
                            with the foregoing provisions or if an adjustment
                            has been made but such adjustment is, in the
                            reasonable determination of the Calculation Agent,
                            insufficient to preserve the economic benefit of the
                            Transaction for the parties, the following
                            additional adjustments shall be made to the terms of
                            the Transaction:

                            If (a) an ordinary cash dividend is declared or paid
                            on the Shares or (b) a special cash dividend is
                            declared or paid on the Shares and in either case
                            the Ex-Dividend Date with respect to such dividend
                            occurs during the period from, and including, the
                            Effective Date to, but excluding, the Expiration
                            Date (each, a "Dividend Event"), the Strike Price
                            shall be adjusted for each Dividend Event in
                            accordance with the following formula:

 
                                           SP\\0\\ (CP\\0\\ - DA)
                                           ----------------------
                                    SP\\1 \\   =   CP\\0\\
 
                                           Where:

                            (i)   SP\\1\\ = Strike Price after the Dividend
                                  Event

                            (ii)  SP\\0\\ = Strike Price on the Exchange
                                  Business Day immediately preceding the Ex-
                                  Dividend Date with respect to the Dividend
                                  Event
 
                            (iii) CP\\0\\ = The closing price of the Shares, as
                                  reported on the Exchange, on the Exchange
                                  Business Day immediately preceding the Ex-
                                  Dividend Date with respect to the Dividend
                                  Event

                            (iv)  DA = The amount of the ordinary cash dividend
                                  or the special cash dividend, as the case may
                                  be

Miscellaneous
- -------------

Transfer             :      Neither party may transfer the Transaction, in whole
                            or in part, without the prior written consent of the
                            non-transferring party.

Account Details
- ---------------

Payments and deliveries to Party A:

     Account for payments:          Previously Provided

     Delivery instructions:         Previously Provided

Payments and deliveries to Party B:

     Account for payments:          Previously Provided

     Delivery instructions:         Previously Provided

 
Please confirm that the foregoing correctly sets forth the terms of our
agreement by executing the copy of this Confirmation enclosed for that purpose
and returning it to us or by sending to us a letter or telex substantially
similar to this letter, which letter or telex sets forth the material terms of
the Transaction to which this Confirmation relates and indicates your agreement
to those terms.

Yours sincerely,

SWISS BANK CORPORATION, LONDON BRANCH


By: /s/ Victoria Harkness Sotgiu       By: /s/ John Marshall
    -----------------------------          ----------------------------
Name:  Victoria Harkness Sotgiu        Name:  John Marshall
Title: Authorised Signatory            Title: Authorised Signatory



Confirmed as of the 22nd day
of October, 1997

MYRIAD GENETICS, INC.



By: /s/ Jay M. Moyes
    ------------------------------
Name: Jay M. Moyes
Title: C.F.O.