EXHIBIT 10.33


                              AMENDMENT AGREEMENT
                                    between
                        SmithKline Beecham Corporation
                                      and
                           NPS Pharmaceuticals, Inc.
                            dated October 27, 1997.






 
                                                                   27 October 97

NPS Pharmaceuticals, Inc.
420 Chipeta Way
Salt Lake City, Utah  84108

     RE:  Amendment Agreement

Dear Sirs:

     This Amendment Agreement (hereinafter "Amendment Agreement") will confirm
that the Letter Agreement dated October 28, 1996 between NPS Pharmaceuticals,
Inc., a corporation of the state of Delaware, having a place of business at 420
Chipeta Way, Salt Lake City, Utah 84108, U.S.A. (herein referred to as "NPS")
and SmithKline Beecham Corporation, a corporation of the Commonwealth of
Pennsylvania, having a place of business at One Franklin Plaza, Philadelphia,
Pennsylvania 19101, U.S.A. (hereinafter referred to as "SB") shall be amended,
effective as of the date of NPS' signature below, as follows:

   . In Paragraph 2.01, delete the words "four (4) years" and replace them with
     the words "forty nine (49) months";

   . All other terms and conditions of the Letter Agreement shall remain in full
     force and effect.

     Please indicate your acceptance of this Amendment Agreement by signing and
dating the duplicate copies of this letter below and returning on such fully
executed copy to SB.

                                        Very truly yours,
                                        SMITHKLINE BEECHAM CORPORATION

                                        By:     /k/ Tamar Howson
                                           -------------------------------------

                                        Title:  Senior VP, Business Development
                                              ----------------------------------

                                        Date:   10/31/97
                                             -----------------------------------

AGREED TO AND ACCEPTED:
NPS PHARMACEUTICALS, INC.

By:    /k/ Hunter Jackson
   -----------------------

Title: CEO
      --------------------