EXHIBIT 10.3

 
                                 ADDENDUM NO. 2
                           TO MASTER LEASE AGREEMENT
                         DATED AS OF DECEMBER 31, 1998


     THIS ADDENDUM amends and supplements above lease (the "Lease"), between
GENERAL ELECTRIC CAPITAL CORPORATION ("Lessor") and MYRIAD GENETICS, INC.
("Lessee") and is hereby incorporated into the Lease as though fully set forth
therein.  Capitalized terms not otherwise defined herein shall have the meanings
set forth in the Lease.

     The Lease is hereby amended as follows:

     The following is added as paragraph two to Section III (b):

              If, solely as a result of Congressional enactment of any law
   (including, without limitation, any modification of, or amendment or addition
   to, the Code, as amended, the Effective Rate is lower than thirty-five
   percent (35%) for 1998 or any subsequent year during the lease term, then
   Lessee shall have the right to request a decrease in the rent payments by
   requiring the Lessor to make a payment of a single sum equal to the product
   of (i) the Effective Rate (expressed as a decimal) for such year less .35
   (or, in the event that any adjustment has been made hereunder for any
   previous year, the Effective Rate (expressed as a decimal) used in
   calculating the next previous adjustment) times (ii) the adjusted Stipulated
   Loss Value divided by the difference between the new Effective Tax Rate
   (expressed as a decimal) and one (1). The adjusted Stipulated Loss Value
   shall be the Stipulated Loss Value (calculated as of the first rental due in
   the year for which such adjustment is being made) less the Tax Benefits that
   would be allowable under Section 168 of the Code (as of the first day of the
   year for which such adjustment is being made and all subsequent years of the
   lease term). Lessor shall pay to Lessee the full amount of the reduction rent
   payment on the later of (i) receipt of notice or (ii) the first day of the
   year for which such adjustment is being made.


     Except as expressly modified hereby, all terms and provisions of the Lease
shall remain in full force and effect.  This Addendum is not binding or
effective with respect to the Lease or the Equipment until executed on behalf of
Lessor and Lessee by authorized representatives of Lessor and Lessee.

     IN WITNESS WHEREOF, Lessee and Lessor have caused this Addendum to be
executed by their duly authorized representatives as of the date first above
written.


LESSOR:                             LESSEE:

GENERAL ELECTRIC CAPITAL            MYRIAD GENETICS INC. 
CORPORATION    

By:      /s/ Steve Mann             By:    /s/ Jay M. Moyes
   ---------------------------         -------------------------------

Name:    Steve Mann                 Name:  Jay M. Moyes
     -------------------------           -----------------------------

Title:   Risk Analyst               Title: V.P. Finance/C.F.O.
      ------------------------            ----------------------------


                                    Attest:

                                    By:    /s/ Jeff Johnson
                                       -------------------------------