SCHEDULE 14A
                    Proxy Statement Pursuant to Section 14(a)
             of the Securities Exchange Act of 1934 (Amendment No.)


Filed by the Registrant                     [ ]

Filed by a Party other than the Registrant  [x]

Check the appropriate box:

[X]  Preliminary Proxy Statement
[ ]  Confidential, for Use of the Commission Only (as permitted by
     Rule 14a-6(e)(2))
[ ]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to ss. 240.14a-12

                          AMYLIN PHARMACEUTICALS, INC.
                (Name of Registrant as Specified In Its Charter)

                                  CARL C. ICAHN
                             DR. ALEXANDER J. DENNER
                               DR. THOMAS F. DEUEL
                               MR. JULES HAIMOVITZ
                                DR. PETER LIEBERT
                               DR. DAVID SIDRANSKY
                                    MAYU SRIS
                                 JEFFREY MECKLER
                                    ERIC ENDE
                                ICAHN PARTNERS LP
                          ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                        ICAHN PARTNERS MASTER FUND III LP
                           ICAHN ENTERPRISES G.P. INC.
                         ICAHN ENTERPRISES HOLDINGS L.P.
                                   IPH GP LLC
                               ICAHN CAPITAL L.P.
                                ICAHN ONSHORE LP
                                ICAHN OFFSHORE LP
                                  BECKTON CORP.
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of Filing Fee (check the appropriate box):

[X] No fee required.

[ ] Fee computed on table below per Exchange Act Rule 14a-6(i)(4) and 0-11.

    1) Title of each class of securities to which transaction applies:

    2) Aggregate number of securities to which transaction applies:

    3) Per unit price or other  underlying  value of  transaction  computed
       pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
       filing fee is calculated and state how it was determined):

    4) Proposed maximum aggregate value of transaction:

    5) Total fee paid:

[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided  by  Exchange  Act
    Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was
    paid  previously.  Identify the previous filing by  registration  statement
    number, or the Form or Schedule and the date of its filing.

    1) Amount Previously Paid:

    2) Form, Schedule or Registration Statement No.:

    3) Filing Party:

    4) Date Filed:





                       2009 ANNUAL MEETING OF STOCKHOLDERS

                                       OF

                          AMYLIN PHARMACEUTICALS, INC.

                               -------------------

                                 PROXY STATEMENT
                               [PRELIMINARY COPY]
                                       OF

                                  CARL C. ICAHN
                             DR. ALEXANDER J. DENNER
                               DR. THOMAS F. DEUEL
                               MR. JULES HAIMOVITZ
                                DR. PETER LIEBERT
                               DR. DAVID SIDRANSKY
                                    MAYU SRIS
                                 JEFFREY MECKLER
                                    ERIC ENDE
                                ICAHN PARTNERS LP
                          ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                        ICAHN PARTNERS MASTER FUND III LP
                           ICAHN ENTERPRISES G.P. INC.
                         ICAHN ENTERPRISES HOLDINGS L.P.
                                   IPH GP LLC
                               ICAHN CAPITAL L.P.
                                ICAHN ONSHORE LP
                                ICAHN OFFSHORE LP
                                  BECKTON CORP.

                               -------------------

To Our Fellow Amylin Stockholders:

     This  Proxy  Statement  and the  accompanying  GOLD  proxy  card are  being
furnished  to  stockholders  ("Stockholders")  of Amylin  Pharmaceuticals,  Inc.
("Amylin" or "Company") in connection  with the  solicitation of proxies by Carl
C. Icahn and certain of his  affiliates and  associates,  to be used at the 2009
Annual  Meeting  (the  "Annual  Meeting")  of  Stockholders  of Amylin  which is
scheduled  to  be  held  at [  ],  local  time,  on [ ],  at  [ ],  and  at  any
adjournments,  postponements or continuations  thereof. This Proxy Statement and
the GOLD proxy card are first being furnished to Stockholders on or about [ ].

     At the Annual Meeting,  the Participants (as hereinafter defined) will seek
to elect to the Board of  Directors  of Amylin  the  following  persons  (each a
"Nominee" and collectively, the "Nominees"):

                             Dr. Alexander J. Denner
                               Dr. Thomas F. Deuel
                               Mr. Jules Haimovitz
                                Dr. Peter Liebert
                               Dr. David Sidransky

     Each of the  Nominees  has  each  consented  to being  named in this  Proxy
Statement and, if elected, to serve as a director.

     Under the proxy rules as written we are required  either to solicit proxies
only  for  our  Nominees,   which  would  result  in  limiting  the  ability  of
Stockholders to fully exercise their voting rights to vote for a full complement
of directors, or alternatively to solicit proxies in support of our Nominees and
also to seek authority from  Stockholders to vote for all of the Amylin Nominees
other than those Amylin  Nominees we specify,  which enables a  Stockholder  who
desires to vote for a full  complement  of twelve  director  nominees to use the
GOLD proxy card to vote for our  Nominees as well as for all or some of those of
the Amylin Nominees for whom we are seeking authority to vote.

     At the Annual Meeting, the Icahn Parties (as hereinafter defined) will also
introduce a resolution to ask the Board of Directors  (the "Board") of Amylin to
promptly initiate and complete the necessary and appropriate process so that the
Stockholders  of Amylin can choose whether to change  Amylin's  jurisdiction  of
incorporation  from Delaware to North Dakota and to become  subject to the North
Dakota  Publicly  Traded  Corporations  Act (the "North  Dakota  Reincorporation
Proposal"). See "the North Dakota Reincorporation Proposal," below.

     The  North  Dakota  Reincorporation  Proposal  requires  for  adoption  the
affirmative  vote of the holders of a majority of the shares  present and voting
on the Proposal.

     THE PARTICIPANTS  URGE YOU TO VOTE FOR DR. ALEXANDER J. DENNER,  DR. THOMAS
F. DEUEL,  MR. JULES  HAIMOVITZ,  DR. PETER  LIEBERT AND DR. DAVID  SIDRANSKY AS
DIRECTORS  AND  THE  ICAHN  PARTIES  URGE  YOU TO  VOTE  FOR  THE  NORTH  DAKOTA
REINCORPORATION PROPOSAL.

     The Nominees and each of the other  Participants have no interest in Amylin
other than through the beneficial  ownership (if any) of shares of Common Stock,
par value $.001 per share, of Amylin (the "Shares") or other securities (if any)
of Amylin as  disclosed  herein,  and,  in the case of Messrs.  Ende and Meckler
pursuant to their Consulting Agreements, as described herein, and in the case of
Dr.  Thomas F. Deuel,  Mr. Jules  Haimovitz,  Dr. Peter  Liebert,  and Dr. David
Sidransky, pursuant to an agreement in which certain affiliates of Carl C. Icahn
have agreed to pay each of Dr. Thomas F. Deuel, Mr. Jules  Haimovitz,  Dr. Peter
Liebert,  and Dr. David  Sidransky  $25,000 and to  indemnify  each Nominee with
respect to certain costs  incurred by each such Nominee in  connection  with the
proxy  contest  relating  to  the  Annual  Meeting  (the  "Nominee  Agreement").

     DR.  ALEXANDER J. DENNER,  DR. THOMAS F. DEUEL,  MR. JULES  HAIMOVITZ,  DR.
PETER  LIEBERT  AND DR.  DAVID  SIDRANSKY  ARE  COMMITTED  TO ACTING IN THE BEST
INTEREST OF ALL STOCKHOLDERS OF AMYLIN.  THE PARTICIPANTS  URGE YOU TO VOTE YOUR
GOLD PROXY CARD FOR DR.  ALEXANDER J.  DENNER,  DR.  THOMAS F. DEUEL,  MR. JULES
HAIMOVITZ,  DR. PETER LIEBERT AND DR. DAVID SIDRANSKY AND THE ICAHN PARTIES URGE
YOU TO VOTE FOR THE NORTH DAKOTA REINCORPORATION PROPOSAL.





                                    IMPORTANT

     According to Amylin's Proxy  Statement,  the Bylaws and applicable law, the
election of the  Nominees  requires the  affirmative  vote of a plurality of the
votes  cast by the  holders  of  Amylin's  Common  Stock at a meeting at which a
quorum  is  present  in  person or  represented  by proxy  and the North  Dakota
Reincorporation  Proposal  requires  the  affirmative  vote of a majority of the
votes  cast by the  holders  of  Amylin's  Common  Stock at a meeting at which a
quorum is present in person or represented by proxy.  As a result,  your vote is
extremely  important.  We urge you to mark,  sign, date, and return the enclosed
GOLD  proxy  card to vote FOR the  election  of each  Nominee  and FOR the North
Dakota Reincorporation Proposal.

     WE URGE YOU NOT TO SIGN ANY PROXY CARD SENT TO YOU BY  AMYLIN.  IF YOU HAVE
ALREADY  DONE SO, YOU MAY REVOKE YOUR PROXY BY  DELIVERING  A  LATER-DATED  GOLD
PROXY  CARD IN THE  ENCLOSED  POSTAGE-PREPAID  ENVELOPE,  EXECUTING  A VOTE  VIA
INTERNET OR TELEPHONE, OR BY VOTING IN PERSON AT THE ANNUAL MEETING. SEE "VOTING
PROCEDURES" AND "PROXY PROCEDURES" BELOW.

     If you attend the annual  meeting and you  beneficially  own shares but are
not the record owner,  your mere  attendance  at the Annual  Meeting WILL NOT be
sufficient  to cancel  your  prior  given  proxy  card.  You must  have  written
authority  from the record  owner to vote the shares in its name at the meeting.
Contact D.F.  King & Co.,  Inc. at the number shown in this proxy  statement for
assistance or if you have any questions.

     If you have any  questions  or require any  assistance  in  executing  your
proxy, please call:

                              D.F. KING & CO., INC.
                   STOCKHOLDERS CALL TOLL-FREE: (800) 488-8075
                 BANKS AND BROKERS CALL COLLECT: (212) 269-5550

     Only  holders of record of Amylin's  voting  securities  as of the close of
business on [ ](the "Record  Date") are entitled to notice of, and to attend and
to vote at, the Annual Meeting and any  adjournments or  postponements  thereof.
According  to the  proxy  statement  of Amylin  filed  with the  Securities  and
Exchange Commission  ("Amylin's Proxy Statement"),  as of the Record Date, there
were outstanding [ ] shares of Common Stock. Stockholders of record at the close
of  business  on the  Record  Date will be  entitled  to one vote at the  Annual
Meeting for each share of Common Stock of Amylin held on the Record Date.

     As of the Record Date, the Participants  and their affiliates  beneficially
owned an aggregate of [ ] shares of Common Stock, representing approximately [ ]
of the outstanding shares of Common Stock. The Participants and their affiliates
intend to vote such shares FOR the  election of the  Nominees  and FOR the North
Dakota Reincorporation Proposal.

     VOTE FOR THE NOMINEES AND FOR THE NORTH DAKOTA REINCORPORATION  PROPOSAL BY
USING THE ENCLOSED GOLD PROXY TO VOTE TODAY - BY TELEPHONE,  BY INTERNET,  OR BY
MARKING,  SIGNING,  DATING AND RETURNING THE GOLD PROXY CARD IN THE POSTAGE-PAID
ENVELOPE PROVIDED TO YOU.




PARTICIPANTS IN SOLICITATION OF PROXIES

     In addition to the Nominees (who are Dr. Alexander J. Denner, Dr. Thomas F.
Deuel, Mr. Jules Haimovitz,  Dr. Peter Liebert,  and Dr. David  Sidransky),  the
participants  in  the   solicitation  of  proxies  (the   "Participants")   from
stockholders of Amylin  Pharmaceuticals,  Inc.  ("Amylin" or the  "Corporation")
include the following:  Mr. Carl C. Icahn,  Mr. Mayu Sris, Mr. Jeffrey  Meckler,
Mr.  Eric Ende,  Icahn  Partners  LP, a  Delaware  limited  partnership  ("Icahn
Partners"),  Icahn Partners Master Fund LP, a Cayman Islands limited partnership
("Icahn  Master"),  Icahn Partners  Master Fund II LP, a Cayman Islands  limited
partnership  ("Icahn Master II"),  Icahn  Partners  Master Fund III LP, a Cayman
Islands  limited  partnership  ("Icahn  Master III"),  Beckton Corp., a Delaware
corporation  ("Beckton"),  Icahn  Enterprises G.P. Inc., a Delaware  corporation
("Icahn  Enterprises GP"), Icahn  Enterprises  Holdings L.P., a Delaware limited
partnership  ("Icahn  Enterprises  Holdings"),  IPH GP LLC, a  Delaware  limited
liability  company  ("IPH"),  Icahn Capital LP, a Delaware  limited  partnership
("Icahn  Capital"),  Icahn Onshore LP, a Delaware  limited  partnership  ("Icahn
Onshore")  and  Icahn  Offshore  LP,  a  Delaware  limited  partnership  ("Icahn
Offshore").

     The address of Icahn  Partners,  Icahn  Enterprises  GP, Icahn  Enterprises
Holdings, Beckton, IPH, Icahn Capital, Icahn Onshore and Icahn Offshore is White
Plains Plaza,  445 Hamilton  Avenue - Suite 1210,  White Plains,  NY 10601.  The
address of Icahn Master, Icahn Master II and Icahn Master III is c/o Walkers SPV
Limited,  P.O. Box 908GT,  87 Mary Street,  George Town,  Grand  Cayman,  Cayman
Islands.  The business address of each of Messrs.  Icahn, Denner, Sris, Ende and
Meckler is c/o Icahn Associates  Corp., 767 Fifth Avenue,  Suite 4700, New York,
NY 10153. Dr. Deuel's business  address is The Scripps Research  Institute,  MEM
268, 10550 North Torrey Pines Road, La Jolla,  California 92037. Mr. Haimovitz's
business  address is 14035 Aubrey Road,  Beverly Hills,  California  90210.  Dr.
Liebert's,  business address is 222 Westchester Avenue, Suite 403, White Plains,
New York 10604. Dr.  Sidransky's  business address is Johns Hopkins University -
Cancer Research Building II, 1550 Orleans Street, Suite 503, Baltimore, Maryland
21231.

     Icahn  Partners,  Icahn  Master,  Icahn  Master  II and  Icahn  Master  III
(collectively,  the "Icahn  Parties" or the "Funds") are entities  controlled by
Mr. Icahn.  Dr. Denner and Mr. Sris are employees  and/or officers and directors
of the Icahn Parties and various other entities controlled by Mr. Icahn, who may
also  participate in soliciting  proxies from Amylin  Stockholders.  Dr. Denner,
Messrs.  Sris,  Ende  and  Meckler  do not  own  beneficially  any  interest  in
securities  of Amylin.  Dr.  Denner and Mr.  Sris will not  receive  any special
compensation  in connection  with such  solicitation.  In connection  with their
employment by Mr. Icahn and his affiliated  companies,  Dr. Denner,  among other
employees,  has a participatory  interest in the profits and fees derived by Mr.
Icahn and/or his affiliated  entities the Funds.  Because only a portion of such
profit  interests are distributed and because of Dr. Denner's other  investments
in the Funds, Dr. Denner also has capital accounts in the Funds.  Generally,  in
the aggregate,  Dr. Denner's profit  interests and capital accounts in the Funds
entitle him to less than 2% of the profits generated by the Funds.  Messrs. Ende
and Meckler are independent consultants retained by the Icahn Parties to solicit
proxies and provide consulting  services relating to this solicitation,  another
solicitation  of proxies by the Icahn  Parties and general  consulting  services
relating to other investments by the Icahn Parties.  Assuming the Annual Meeting
of Amylin and the annual  meeting  relating to the other  solicitation  are each
held in May and further  assuming  each  contest is  successful  the  agreements
referred to herein may provide for payments of up to approximately $325,000.00

     Each of the  Icahn  Parties  is  principally  engaged  in the  business  of
investing in securities.

     Annex A  attached  hereto  sets  forth,  as to the  Nominees  and the other
Participants,  all transactions in securities of Amylin effected during the past
two years and their beneficial ownership of securities of Amylin.

     With respect to each  Participant  (including the Nominees),  except as set
forth herein or in any of the Annexes attached  hereto,  (i) such Participant is
not,  nor was within  the past year,  a party to any  contract,  arrangement  or
understanding  with  any  person  with  respect  to any  securities  of  Amylin,
including, but not limited to, joint ventures, loan or option arrangements, puts
or calls, guarantees against loss or guarantees of profit, division of losses or
profits,  or the  giving  or  withholding  of  proxies;  and (ii)  neither  such
Participant  nor any of such  Participant's  associates  have any arrangement or
understanding  with any person  with  respect to (A) any  future  employment  by
Amylin or its affiliates or (B) any future  transactions  to which Amylin or any
of its affiliates will or may be a party.


PROPOSAL 1 -- ELECTION OF DIRECTORS

     On  January  30,  2009 the Icahn  Parties  delivered  a letter  to  Amylin,
notifying  Amylin that the Icahn  Parties  intend to  nominate  and will seek to
elect at the Annual Meeting - Dr. Alexander J. Denner,  Dr. Thomas F. Deuel, Mr.
Jules  Haimovitz,  Dr. Peter  Liebert and Dr. David  Sidransky as members of the
board of directors of Amylin. Each Nominee,  if elected,  would serve a one-year
term and hold office until the 2010 annual meeting of  Stockholders  and until a
successor has been duly elected and qualified. Background information about each
of the Nominees is set forth below.  According to Amylin's Proxy Statement,  the
Board of Directors of Amylin (the "Board") intends to nominate twelve candidates
for  election  as  directors  at the Annual  Meeting.  This proxy  statement  is
soliciting  proxies to elect Dr.  Alexander J. Denner,  Dr. Thomas F. Deuel, Mr.
Jules  Haimovitz,  Dr. Peter  Liebert,  and Dr. David  Sidransky,  and to enable
Stockholders to vote for the Amylin nominees other than [the following  persons:
]. Under  applicable  proxy rules we are required either to solicit proxies only
for the Nominees,  which could result in limiting the ability of Stockholders to
fully  exercise  their voting  rights with respect to Amylin's  nominees,  or to
solicit  for the  Nominees  and to provide  Stockholders  with a proxy card that
allows such Stockholder to vote for fewer than all of Amylin's  nominees,  which
enables a Stockholder  who desires to vote for the Nominees to also vote for the
Amylin  nominees other than those Amylin  nominees listed on our proxy card. You
may also  withhold  authority  with  respect to any Nominee or any of the Amylin
nominees by writing the name of that  nominee on the  enclosed  GOLD proxy card.
There can be no  assurance  that any of the Amylin  nominees  will,  if elected,
serve with any of our Nominees.

     The Company has disclosed in its 2009  Preliminary  Proxy Statement that if
as a result of the  election of our  Nominees  and the  nominees  of  Eastbourne
Capital Management, L.L.C. ("Eastbourne"),  a majority of the Board ceases to be
composed of the incumbent directors or other individuals  approved by a majority
of the  incumbent  directors,  then a "change of  control"  under the  Company's
credit  agreement  and a  "fundamental  change"  under  the  indenture  for  the
Company's convertible notes due 2014 ("2007 Notes") will be triggered. While the
Company  indicated  that it believes  that its current  Board has the ability to
approve any nominees proposed for election by either the Icahn Parties and/or by
Eastbourne at any time up to the election and avoid occurrence of a "fundamental
change"  under the  indenture  for 2007  Notes in the event six or more of those
nominees are elected,  the Company's  proxy statement has not indicated that the
Board of Directors  has made such  determination.  In addition,  the Company has
stated that approval of the non-management  nominees cannot avoid the occurrence
of a "change of  control"  under the credit  agreement  in the event six or more
non-management  are elected.  You should refer to the Company's 2009 Preliminary
Proxy Statement and other public filings for more  information  concerning these
provisions. We strongly believe that the Board of Directors has a fiduciary duty
to tell  Stockholders  whether  the Board  will  approve  the  Nominees  and the
Eastbourne  Nominees,  so  Stockholders  may know the effects of their votes and
thereby exercise free choice in casting those votes.

     Dr.  Alexander J. Denner,  Dr. Thomas F. Deuel,  Mr. Jules  Haimovitz,  Dr.
Peter  Liebert  and  Dr.  David   Sidransky  are  each  party  to  an  agreement
substantially  in the form  attached  hereto as Annex B,  pursuant  to which the
Icahn  Parties have agreed to pay certain fees to each such Nominee  (other than
Dr.  Denner) and to indemnify  each such  Nominee with respect to certain  costs
incurred by each such Nominee in connection  with the proxy contest  relating to
the Annual Meeting (the "Nominee Agreement").  Except as disclosed in this Proxy
Statement,  including the Annexes attached hereto and as provided in the Nominee
Agreement  (which,  among other  things,  provides  for a payment to each of Dr.
Thomas F. Deuel, Mr. Jules Haimovitz, Dr. Peter Liebert, and Dr. David Sidransky
of $25,000),  none of the Nominees will receive any compensation from any of the
Participants  or  any  of  their   affiliates  in  connection  with  this  proxy
solicitation.  Dr. Thomas F. Deuel, Mr. Jules Haimovitz,  Dr. Peter Liebert, and
Dr. David  Sidransky have an interest in the election of directors at the Annual
Meeting pursuant to the Nominee Agreement relating to such Nominee.  Dr. Liebert
has an interest in the  election  through his  ownership  of 2,000  Shares.  Dr.
Denner has an  interest  in the  election  of  directors  at the Annual  Meeting
indirectly through his capital accounts and other investments in the Funds.

     The Nominees would not be barred from being  considered  independent  under
the  independence  requirements  of  The  NASDAQ  Stock  Market,  Inc.  and  the
independence  standards  applicable to Amylin under paragraph (a)(1) of Item 407
of Regulation S-K under the Securities Exchange Act of 1934, as amended.

     Other than as  disclosed  in this Proxy  Statement,  including  the Annexes
attached hereto, (i) the Nominees are not, nor were they within the past year, a
party to any contract, arrangement or understanding with any person with respect
to any securities of Amylin, including, but not limited to, joint ventures, loan
or option arrangements,  puts or calls, guarantees against loss or guarantees of
profit,  division of losses or profits, or the giving or withholding of proxies;
and (ii) none of the Nominees nor any of their  respective  associates  have any
arrangement  or  understanding  with any person  with  respect to (A) any future
employment by Amylin or its affiliates or (B) any future  transactions  to which
Amylin or any of its affiliates will or may be a party.

DR. ALEXANDER J. DENNER

     Dr.  Alexander  J.  Denner,  39,  serves as  Managing  Director of entities
affiliated with Carl C. Icahn,  including Icahn  Partners,  Icahn Master,  Icahn
Master II and Icahn Master III. Icahn  Partners,  Icahn Master,  Icahn Master II
and Icahn Master III are private investment funds. Dr. Denner has served in this
position since August 2006.  From April 2005 to May 2006, Dr. Denner served as a
portfolio  manager  specializing  in  healthcare  investments  for Viking Global
Investors.  Previously,  he  served in a  variety  of roles at  Morgan  Stanley,
beginning  in  1996,   including  as  portfolio   manager  of   healthcare   and
biotechnology  mutual  funds.  Dr.  Denner  was the  chairman  of the  Executive
Committee of the Board of Directors of ImClone Systems Incorporated,  a publicly
traded biopharmaceutical company, and a director of ImClone Systems Incorporated
from April 2006 until the company was  purchased in November  2008. In addition,
Dr. Denner has served as a director of Adventrx Pharmaceuticals Inc., a publicly
traded  biopharmaceutical  company since October 2006.  Dr. Denner  received his
S.B.  degree  from the  Massachusetts  Institute  of  Technology  and his  M.S.,
M.Phil., and Ph.D. degrees from Yale University.

DR. THOMAS F. DEUEL

     Dr.  Deuel,  74, is  currently a Professor of  Molecular  and  Experimental
Medicine  and Cell  Biology,  Director of the  Division of  Molecular  Oncology,
Department of Molecular and Experimental  Medicine, and Director of the Vascular
Biology  Affinity Group at The Scripps  Research  Institute since February 2002.
Also,  since 1998,  Dr.  Deuel has served as a Professor  of Medicine at Harvard
Medical School. He is currently a Professor  Emeritus at Harvard Medical School.
In addition,  from 1996 to 2002,  Dr.  Deuel  served as a Director,  Division of
Growth Regulation at Beth Israel Hospital,  Boston,  Massachusetts and, prior to
that,  was a Professor  of Medicine  and  Biochemistry  and the head of Oncology
Services at the Washington University School of Medicine,  St. Louis,  Missouri.
He is a member of the Institute of Medicine at the National Academy of Sciences.
Dr. Deuel is also President of the Edward R. Mallinckrodt Foundation, St. Louis,
Missouri.  He has served on various editorial  boards,  including the Journal of
Clinical  Investigation  and Blood,  and currently is on the Editorial  Board of
Current Opinion in Hematology and Section Editor for Vascular Biology. Dr. Deuel
has served and  continues to serve on numerous  scientific  advisory  boards for
various  companies,  including  scientific  advisory  board of  ImClone  Systems
Incorporated,  a publicly traded biopharmaceutical company, during the existence
of such board (from 1988 to 2001).  From July 2007 to November  2008,  Dr. Deuel
had  served  on  ImClone's  board  of  directors.  Dr.  Deuel  has  earned  many
professional honors and awards and holds an M.D. from Columbia University and an
A.B. from Princeton University.

MR. JULES HAIMOVITZ

     Mr.  Haimovitz,  58, is  currently  President of the  Haimovitz  Consulting
Group. From July 2002 until July 2007, Mr. Haimovitz served as Vice Chairman and
Managing Partner of Dick Clark  Productions  Inc., a producer of programming for
television,  cable  networks and  syndicators.  From June 1999 to July 2004, Mr.
Haimovitz served in various capacities at Metro Goldwyn Mayer Inc., including as
President of MGM  Networks,  Inc., a  wholly-owned  subsidiary  of Metro Goldwyn
Mayer  Inc.,  where he led the  transformation  of MGM's film  library  into new
entertainment channels for worldwide distribution in digital cable and satellite
television.  From July 1997 to February 1999, Mr.  Haimovitz served as President
and  Chief  Operating  Officer  of King  World  Productions  Inc.,  a  worldwide
distributor of first-run programming,  where he oversaw the successful worldwide
distribution of programs such as "Wheel of Fortune," "Jeopardy!," and "The Oprah
Winfrey Show."  Haimovitz has also held senior level executive  positions at ITC
Entertainment  Group,  Polygram N.V.,  Diva Systems  Corporation,  Video Jukebox
Network Inc.,  Spelling  Entertainment  Inc. and Viacom Inc. Mr.  Haimovitz also
served as  director  and  chairman  of the Audit  Committee  of ImClone  Systems
Incorporated,  a publicly traded biopharmaceutical  company, from May 2007 until
November  2008.  Mr.  Haimovitz  currently  serves on the boards of directors of
Blockbuster, Inc., , a publicly traded provider of in-home movie rental and game
entertainment,  Infospace  Inc., a publicly  traded  developer of  private-label
search technology,  and TVN Entertainment  Corporation, a provider of television
on-demand  programs and  networks.  Mr.  Haimovitz  holds a dual B.A.  degree in
Mathematics and  Communications,  as well as an M.A. degree in Mathematics  from
Brooklyn College.

DR. PETER LIEBERT

     Dr.  Liebert,  73, has been a pediatric  surgeon in private  practice since
1968 and is Chief,  Pediatric Surgery of The Stamford  Hospital,  Stamford,  CT.
From 1981 to 2006,  Dr. Liebert was Clinical  Associate  Professor of Surgery at
the College of  Physicians  & Surgeons of Columbia  University.  Dr.  Liebert is
currently President of the Westchester Surgical Society. Dr. Liebert is a former
president of the  Westchester  County Medical Society and a former member of the
Awards Jury of the Lasker Foundation. Dr. Liebert is Chairman of the Board of Rx
Vitamins,  Inc. and is a director of Cadus  Corporation,  a publicly held,  drug
discovery company  controlled by Carl C. Icahn. Dr. Liebert served as a director
of ImClone  Systems  Inc., a  biotechnology  company,  between  October 2006 and
November 2008. Dr. Liebert holds an M.D. from Harvard Medical School and an A.B.
from Princeton University.

DR. DAVID SIDRANSKY

     Dr.  Sidransky,  48, is the  Director of the Head and Neck Cancer  Research
Division at Johns  Hopkins  University  School of  Medicine.  He is a founder of
several private  biotechnology  companies and has served on scientific  advisory
boards of many private and publicly traded companies,  including MedImmune Inc.,
Telik Inc.,  Roche,  and Amgen Inc. Dr. Sidransky is also a director of Alfacell
Inc.  He was  formerly on the Board of  Scientific  Counselors  at the  National
Institute of Dental and  Craniofacial  Research and a member of the  Recombinant
DNA Advisory Committee at the National Institute of Health. Dr. Sidransky serves
on numerous  editorial  boards and is Senior Editor of Clinical Cancer Research.
In  addition,  he is a  Professor  of  Oncology,  Otolaryngology-Head  and  Neck
Surgery,  Cellular & Molecular  Medicine,  Urology,  Genetics,  and Pathology at
Johns Hopkins  University and Hospital.  Dr.  Sidransky is certified in Internal
Medicine and Medical Oncology by the American Board of Medicine. He has over 390
peer-reviewed publications,  and has contributed more than 60 cancer reviews and
chapters and also has numerous  issued  biotechnology  patents.  He has been the
recipient of many awards and honors,  including the 1997 Sarstedt  International
Prize from the German  Society of  Clinical  Chemistry,  the 1998 Alton  Ochsner
Award Relating  Smoking and Health by the American  College of Chest  Physicians
and the 2004 Hinda and Richard Rosenthal Award from the American  Association of
Cancer Research. Dr. Sidransky is also the Chairman of the Board of Directors of
Champions Biotechnology,  Inc. Dr. Sidransky has served as a director of ImClone
Systems Inc., a biotechnology  company,  between January 2004 and November 2008.
Dr. Sidransky  received his B.A. from Brandeis  University and his M.D. from the
Baylor College of Medicine.

     WE STRONGLY  URGE YOU TO VOTE FOR THE ELECTION OF DR.  ALEXANDER J. DENNER,
DR.  THOMAS F. DEUEL,  MR.  JULES  HAIMOVITZ,  DR.  PETER  LIEBERT AND DR. DAVID
SIDRANSKY BY MARKING, SIGNING, DATING AND RETURNING THE ENCLOSED GOLD PROXY CARD
IN THE POSTAGE  PAID  ENVELOPE  PROVIDED TO YOU WITH THIS PROXY  STATEMENT OR BY
USING THE GOLD PROXY CARD TO VOTE BY TELEPHONE  OR INTERNET.  IF YOU HAVE SIGNED
THE GOLD PROXY  CARD AND NO MARKING IS MADE,  YOU WILL BE DEEMED TO HAVE GIVEN A
DIRECTION  TO VOTE ALL THE  SHARES  REPRESENTED  BY THE GOLD  PROXY CARD FOR THE
ELECTION OF DR.  ALEXANDER J. DENNER,  DR. THOMAS F. DEUEL, MR. JULES HAIMOVITZ,
DR. PETER  LIEBERT AND DR. DAVID  SIDRANSKY AND THE AMYLIN  NOMINEES  OTHER THAN
[THE FOLLOWING PERSONS:].


PROPOSAL 2 -- NORTH DAKOTA REINCORPORATION PROPOSAL

The proposal states:

               "RESOLVED,  that  the  stockholders  of  the  Corporation  hereby
          request the Board of Directors of the  Corporation  to take all action
          as is necessary and appropriate to properly  initiate and complete the
          process to change the Corporation's jurisdiction of incorporation from
          Delaware  to North  Dakota and to become  subject to the North  Dakota
          Publicly Traded Corporations Act."

     The   Icahn    Parties    believe   that   North   Dakota   is   the   most
stockholder-friendly   jurisdiction   in  the  United   States  and  that  being
incorporated  there  and  subject  to  the  North  Dakota  Act  would  give  the
stockholders  considerably more protection against  management  entrenchment and
would make it easier for third parties to successfully  bid for the Corporation.
Although there can be no  assurances,  this could enable  stockholders,  in some
cases, to achieve a premium over market for their shares.

     Other   than  the  change  in   corporate   domicile,   the  North   Dakota
Reincorporation  is not  intended  to  result  in any  change  in the  business,
physical location,  management, assets, liabilities or net worth of the Company,
nor is it intended  to result in any change in  location  of Company  employees,
including  the  Company's  management.  Upon  consummation  of  a  North  Dakota
Reincorporation,  it is anticipated  that the daily  business  operations of the
Company will continue as they are presently conducted.

Principal Reasons for the Reincorporation

     The  Icahn   Parties   believe  that  there  are  several   reasons  why  a
reincorporation  to North  Dakota  and  becoming  subject  to the  North  Dakota
Publicly  Traded  Corporations  Act is in the best  interests  of Amylin and its
Stockholders.  If the Company were governed by the North Dakota  Publicly Traded
Corporations Act:

o    The board of directors would be elected by a majority vote (as opposed to a
     mere  plurality) and directors  defeated  under the majority  voting system
     would be prohibited  from being appointed by the board of directors to fill
     a vacancy;

o    The board of directors could not be classified  (staggered),  each director
     would be elected every year and the board of directors would not be able to
     change  its size when it has reason to  believe  there will be a  contested
     election;

o    The  chairman  of the board of  directors  could not serve as an  executive
     officer;

o    Shareholders  who have  held  five  percent  (5%) or more of the  Company's
     outstanding shares for at least two years would have access to management's
     proxy statement to nominate directors;

o    All  shareholders  would be reimbursed  for proxy  contest  expenses in the
     election of directors, to the extent they are successful;

o    Shareholders would be statutorily entitled to an advisory vote each year on
     executive compensation (a "say on pay" proposal);

o    The ability of the board of  directors  to adopt and maintain a poison pill
     would be limited in several respects;

o    Antitakeover  provisions proposed for inclusion in the Company's charter or
     bylaws  would  require  the prior  approval  of  two-thirds  of the  shares
     entitled to vote;

o    Shareholders  could not be required  to provide  more than ninety (90) days
     notice in advance of a shareholder  meeting when making  nominations to the
     board  of  directors  and  there  would  be  limitations  on  the  type  of
     information that could be required in connection with such nominations;

o    Shareholders who own 5% or more of the Company's  outstanding  shares would
     have a right to propose and approve  amendments  to the  Company's  charter
     without prior board approval; and

o    The  Company  could not add a  requirement  to its  charter or bylaws  that
     certain actions require the approval of a super majority vote.

     The  North  Dakota   Publicly   Traded   Corporations   Act  would  provide
shareholders  more rights than are  generally  currently  available  under other
state  corporation  laws,  including  Delaware,  where the Company is  currently
incorporated.  Moreover,  the North  Dakota  Publicly  Traded  Corporations  Act
expressly  provides that it "must be liberally  construed to protect and enhance
the rights of shareholders in publicly traded corporations."

     In addition to providing  increased  shareholder  rights,  the North Dakota
Publicly  Traded  Corporations  Act  contains a  franchise  tax  system  that is
specifically  designed to impose  significantly  less cost on companies than the
Delaware   franchise  tax  system,   thereby   providing   additional  value  to
shareholders.

WE STRONGLY  URGE YOU TO VOTE FOR THE NORTH  DAKOTA  REINCORPOATION  PROPOSAL BY
MARKING,  SIGNING,  DATING AND  RETURNING  THE  ENCLOSED  GOLD PROXY CARD IN THE
POSTAGE PAID ENVELOPE  PROVIDED TO YOU WITH THIS PROXY STATEMENT OR BY USING THE
GOLD PROXY CARD TO VOTE BY TELEPHONE  OR  INTERNET.  IF YOU HAVE SIGNED THE GOLD
PROXY CARD AND NO MARKING IS MADE,  YOU WILL BE DEEMED TO HAVE GIVEN A DIRECTION
TO VOTE ALL THE SHARES  REPRESENTED  BY THE GOLD PROXY CARD FOR THE NORTH DAKOTA
REINCORPORATION PROPOSAL.

OTHER MATTERS TO BE CONSIDERED AT THE ANNUAL MEETING

     According to Amylin's Proxy  Statement,  Amylin is soliciting  proxies with
respect to three  proposals  other than the election of directors  and the North
Dakota Reincorporation  Proposal. Please refer to Amylin's Proxy Statement for a
detailed discussion of these proposals,  including various arguments in favor of
and against such  proposals.  These  proposals are outlined  below.  IF YOU HAVE
SIGNED THE GOLD  PROXY  CARD AND NO MARKING IS MADE,  YOU WILL BE DEEMED TO HAVE
GIVEN A DIRECTION TO VOTE ALL OF THE SHARES  REPRESENTED BY YOUR GOLD PROXY CARD
(I) FOR PROPOSAL [ ] BELOW, AND (II) AGAINST PROPOSALS [ ] BELOW.


PROPOSAL 3 -- APPROVAL OF AMYLIN'S 2009 EQUITY INCENTIVE PLAN

According to the Company's 2009 Preliminary  Proxy  Statement,  the Company will
also solicit proxies with respect to a proposal for the  stockholders to approve
the Company's 2009 Equity Incentive Plan ("EIP").  Please refer to the Company's
2009  Preliminary  Proxy  Statement  for a  discussion  of  such  proposal.  The
Participants intend to vote, and recommend that you vote, [ ] this proposal.


PROPOSAL 4 -- APPROVAL OF AMENDMENT OF THE 2001 EMPLOYEE STOCK PURCHASE PLAN

According to the Company's 2009 Preliminary  Proxy  Statement,  the Company will
also solicit proxies with respect to a proposal for the  stockholders to approve
an  increase  of  1,500,000  shares  in the  aggregate  number  of shares of the
Company's common stock authorized for issuance under the Company's 2001 Employee
Stock Purchase Plan (the "2001 Employee Stock Purchase Plan  Proposal").  Please
refer to the Company's 2009 Preliminary Proxy Statement for a discussion of such
proposal.  The Participants intend to vote, and recommend that you vote, [ ]this
proposal.


PROPOSAL  5 --  RATIFICATION  OF  SELECTION  OF  INDEPENDENT  REGISTERED  PUBLIC
                ACCOUNTING FIRM

According to the Company's 2009 Preliminary  Proxy  Statement,  the Stockholders
will be asked to vote to ratify the  selection  of Ernst & Young LLP as Amylin's
independent  registered  public  accounting  firm  for the  fiscal  year  ending
December 31, 2009. The Participants intend to vote, and recommend that you vote,
[ ] this proposal.

OTHER PROPOSALS

     The  Participants  and their  affiliates  know of no other  business  to be
presented at the Annual  Meeting.  If any other  matters  should  properly  come
before the Annual Meeting, it is intended that the persons named on the enclosed
GOLD proxy card will vote that proxy on such other  matters in  accordance  with
their judgment.


VOTING PROCEDURES

     According  to Amylin's  Proxy  Statement,  the Bylaws and  applicable  law,
holders of shares of  Amylin's  Common  Stock,  at the close of  business on the
Record Date are entitled to notice of, and to vote at, the Annual Meeting.  Each
share of Common Stock  outstanding on the Record Date is entitled to one vote on
each matter presented at the Annual Meeting.

     According  to Amylin's  Proxy  Statement,  the Bylaws and  applicable  law,
directors  are  elected  by a  plurality  of the votes  cast by the  holders  of
Amylin's Common Stock at a meeting at which a quorum is present. Plurality means
that the individuals who receive the largest number of votes cast are elected as
directors,  up to the maximum  number of  directors to be chosen at the meeting.
Consequently,  any shares not voted  (whether by  abstention,  broker nonvote or
otherwise) have no impact in the election of directors. A quorum is the presence
by person or by proxy of a majority  of the Shares  issued and  outstanding  and
entitled to vote at the Annual Meeting. The Shares represented by a proxy marked
"withhold"  or "abstain"  will be considered  present at the Annual  Meeting for
purposes of determining a quorum.


BROKER NON-VOTES

     If you hold your shares through a bank,  broker or other nominee and do not
provide voting instructions to the record holder of the shares, your shares will
not be voted on any  proposal  on which  your  broker or  nominee  does not have
discretionary  authority  to vote.  In this case,  a "broker  non-vote"  occurs.
Shares  constituting broker non-votes are not counted or deemed to be present or
represented for the purpose of determining whether  shareholders have approved a
matter,  but they are counted as present for the purpose of determining a quorum
at the Annual Meeting.

     For the Annual Meeting, because of the solicitation of proxies described in
this proxy  statement,  the  election of  directors  at the Annual  Meeting is a
"non-routine  matter" and brokers do not have  discretionary  authority  to vote
your shares on "non-routine  matters."  Therefore,  unless you provide  specific
voting  instructions  to your  broker,  your broker will not have  discretionary
authority  to vote your  shares  for the  election  of  directors  at the Annual
Meeting  and your  shares  will not be voted  for any of the  nominees.  If your
shares are held in street  name,  your broker or nominee  has  enclosed a voting
instruction  card with this proxy statement.  We strongly  encourage you to vote
your shares by following  the  instructions  provided on the voting  instruction
card

     According to Amylin's Proxy  Statement,  the Bylaws and applicable law, the
affirmative  vote of a majority of Shares  present in person or  represented  by
proxy at the Annual  Meeting and  entitled to vote  thereon are  required to (i)
approve the North Dakota  Reincorporation  Proposal,  (ii)  approval of Amylin's
2009 Equity Incentive Plan; (iii) approval of the amendment to the 2001 Employee
Stock Purchase Plan; and (iv) ratify the selection of the independent registered
accounting firm.

     As explained in the detailed  instructions  on your GOLD proxy card,  there
are four ways you may vote. You may:

     1.   Sign,  date and return the  enclosed  GOLD proxy card in the  enclosed
          postage-paid  envelope.  We recommend  that you vote on the GOLD proxy
          card even if you plan to attend the Annual Meeting;
     2.   Vote via the Internet by following the voting instructions on the GOLD
          proxy card or the voting instructions provided by your broker, bank or
          other holder of record.
     3.   Vote by  telephone by following  the voting  instructions  on the GOLD
          proxy card or the instructions  provided by your broker, bank or other
          holder of record; or
     4.   Vote in person by attending the Annual  Meeting.  Written ballots will
          be  distributed  to  Stockholders  who wish to vote in  person  at the
          Annual  Meeting.  If you hold your  Shares  through a bank,  broker or
          other custodian,  you must obtain a legal proxy from such custodian in
          order to vote in person at the meeting.

     To submit a proxy with voting  instructions  by  telephone  please call the
telephone  number  listed on the GOLD proxy card.  Proxies may also be submitted
over  the  Internet.  Please  refer  to the  GOLD  proxy  card  for the  website
information.  In each case  Stockholders  will be required to provide the unique
control number which has been printed on each  Stockholder's GOLD proxy card. In
addition to the  instructions  that appear on the GOLD proxy card,  step-by-step
instructions  will  be  provided  by a  recorded  telephone  message  for  those
Stockholders  submitting proxies by telephone,  or at the designated website for
those Stockholders submitting proxies over the Internet. Stockholders submitting
their  proxies with voting  instructions  by telephone or over the Internet will
receive  confirmation  on  the  telephone  that  their  vote  by  telephone  was
successfully  submitted,  and may provide an email address for confirmation that
their vote by Internet was successfully submitted.

     Whether or not you are able to attend the Annual Meeting,  you are urged to
complete the enclosed  GOLD proxy and return it in the enclosed  self-addressed,
prepaid envelope. All valid proxies received prior to the meeting will be voted.
If you specify a choice with respect to any item by marking the  appropriate box
on the proxy, the Shares will be voted in accordance with that specification. IF
NO  SPECIFICATION  IS MADE,  THE SHARES WILL BE VOTED (I) FOR DR.  ALEXANDER  J.
DENNER FOR DIRECTOR;  (II) FOR DR.  THOMAS F. DEUEL FOR DIRECTOR;  (III) FOR MR.
JULES HAIMOVITZ FOR DIRECTOR;  (IV) FOR DR. PETER LIEBERT FOR DIRECTOR;  (V) FOR
DR. DAVID  SIDRANSKY FOR DIRECTOR;  (IV) FOR THE PERSONS WHO HAVE BEEN NOMINATED
BY AMYLIN TO SERVE AS DIRECTORS,  OTHER THAN [THE FOLLOWING PERSONS:];  (VI) FOR
THE  NORTH  DAKOTA  REINCORPOATION  PROPOSAL;  (VI)  [ ]  AMYLIN'S  2009  EQUITY
INCENTIVE  PLAN;  (VII) [ ] THE  AMENDMENT TO THE 2001 EMPLOYEE  STOCK  PURCHASE
PLAN; (VIII) [ ] THE RATIFICATION OF THE SELECTION OF THE INDEPENDENT REGISTERED
ACCOUNTING  FIRM; AND (IX) IN THE PROXY HOLDERS'  DISCRETION AS TO OTHER MATTERS
THAT MAY PROPERLY COME BEFORE THE ANNUAL MEETING.

     If you have any  questions  or require any  assistance  in  executing  your
proxy, please call:

                              D.F. KING & CO., INC.
                   STOCKHOLDERS CALL TOLL-FREE: (800) 488-8075
                 BANKS AND BROKERAGE FIRMS CALL: (212) 269-5550

PROXY PROCEDURES

     IN ORDER FOR YOUR VIEWS TO BE  REPRESENTED  AT THE ANNUAL  MEETING,  PLEASE
MARK,  SIGN,  DATE AND RETURN  THE  ENCLOSED  GOLD  PROXY  CARD IN THE  ENCLOSED
POSTAGE-PREPAID  ENVELOPE  OR USE THE GOLD  PROXY CARD TO VOTE BY  TELEPHONE  OR
INTERNET.

     The  accompanying  GOLD proxy  card will be voted at the Annual  Meeting in
accordance with your instructions on such card.

     Only  holders of record as of the close of business on the Record Date will
be entitled to vote. If you were a Stockholder of record on the Record Date, you
will  retain  your  voting  rights at the Annual  Meeting  even if you sell such
shares after the Record  Date.  Accordingly,  it is important  that you vote the
shares held by you on the Record  Date,  or grant a proxy to vote such shares on
the GOLD proxy card, even if you sell such shares after the Record Date.

     IF YOUR SHARES ARE HELD IN THE NAME OF A BROKERAGE FIRM, BANK, BANK NOMINEE
OR OTHER  INSTITUTION ON THE RECORD DATE,  ONLY IT CAN VOTE SUCH SHARES AND ONLY
UPON RECEIPT OF YOUR  SPECIFIC  INSTRUCTIONS.  ACCORDINGLY,  PLEASE  CONTACT THE
PERSON  RESPONSIBLE FOR YOUR ACCOUNT AND INSTRUCT THAT PERSON TO EXECUTE ON YOUR
BEHALF THE GOLD PROXY CARD AS SOON AS POSSIBLE.


REVOCATION OF PROXIES

     Any  Stockholders  of  record  may  revoke  or  change  his  or  her  proxy
instructions at any time prior to the vote at the Annual Meeting by:

     o    submitting  a properly  executed,  subsequently  dated GOLD proxy card
          that will  revoke all prior  proxy  cards,  including  any White proxy
          cards which you may have submitted to Amylin;

     o    instructing  the Icahn  Parties by telephone or via the Internet as to
          how you would like your shares  voted  (instructions  are on your GOLD
          proxy card);

     o    attending  the  Annual  Meeting  and  withdrawing  his or her proxy by
          voting in person  (although  attendance at the Annual Meeting will not
          in and of itself constitute revocation of a proxy); or

     o    delivering  written  notice of revocation  either to the Icahn Parties
          c/o D.F. King & Co., Inc., 48 Wall Street,  New York, NY 10005, or the
          Corporate Secretary of Amylin.

     Although a  revocation  is  effective  if  delivered  to Amylin,  the Icahn
Parties  request that either the original or a copy of any  revocation be mailed
to the Icahn  Parties c/o D.F. King & Co.,  Inc.,  48 Wall Street,  New York, NY
10005, so that the Icahn Parties will be aware of all revocations.

     IF YOU PREVIOUSLY SIGNED AND RETURNED A WHITE PROXY CARD TO AMYLIN, WE URGE
YOU TO REVOKE IT BY (1) MARKING,  SIGNING,  DATING AND  RETURNING THE GOLD PROXY
CARD,  (2)  INSTRUCTING  US BY TELEPHONE OR VIA THE INTERNET AS TO HOW YOU WOULD
LIKE YOUR SHARES VOTED WITH RESPECT TO THE GOLD PROXY CARD,  (3)  ATTENDING  THE
ANNUAL  MEETING  AND  VOTING  IN PERSON OR (4)  DELIVERING  A WRITTEN  NOTICE OF
REVOCATION TO THE ICAHN PARTIES OR TO THE CORPORATE SECRETARY OF THE COMPANY.


COST AND METHOD OF SOLICITATION

     Solicitation  of proxies  shall be made by Dr.  Denner and  Messrs.  Icahn,
Sris, Meckler and Ende.

     The Icahn Parties have retained  D.F.  King & Co.,  Inc.  ("D.F.  King") to
conduct the solicitation,  for which D.F. King is to receive a fee not to exceed
$150,000,  plus  reimbursement for its reasonable  out-of-pocket  expenses.  The
Icahn Parties have agreed to indemnify D.F. King against certain liabilities and
expenses,  including  certain  liabilities  under the federal  securities  laws.
Insofar as indemnification  for liabilities arising under the federal securities
laws may be permitted to D.F. King pursuant to the foregoing provisions, we have
been informed,  that in the opinion of the  Securities and Exchange  Commission,
such  indemnification  is against public policy and is therefore  unenforceable.
Proxies may be  solicited  by mail,  courier  services,  Internet,  advertising,
telephone or  telecopier  or in person.  It is  anticipated  that D.F. King will
employ up to [75] persons to solicit  proxies from Amylin  Stockholders  for the
Annual Meeting. The total expenditures in furtherance of, or in connection with,
the solicitation of proxies is approximately [$] to date, and is estimated to be
[$] in total.

     The Icahn  Parties  do not intend to seek  reimbursement  for the costs and
expenses  associated  with the proxy  solicitation  in the event that any of the
Nominees are elected to the Board of Directors of Amylin.


CERTAIN LITIGATION

     The Company has issued $575 million of notes (the  "Notes"),  the indenture
for which  (the  "Indenture")  provides  the  holders  of the Notes the right to
require  the  Company to  repurchase  the Notes at a price  equal to 100% of the
principal  amount thereof,  together with accrued and unpaid  interest  thereon,
within  35  days  after  the  date  upon  which  "continuing  directors"  do not
constitute a majority of the Company's Board of Directors.  Under the Indenture,
"continuing directors" are individuals who constituted the Board of Directors on
the issue date of the Notes, or any new directors whose election to the Board or
nomination  for election  was  approved by at least a majority of the  directors
still in office.

     The Company is also party to a Credit Agreement with certain banks dated as
of December 21, 2007  pursuant to which the Company has borrowed  $125  million.
Under the Credit  Agreement,  borrowed funds become  repayable upon a "change of
control,"  which is defined to occur when  persons who were members of the Board
at the start of any 24 month  period  no longer  constitute  a  majority  of the
Board,  unless the  nomination  of the new  directors  was approved by the prior
members  of the  board,  other  than as a  result  of an  actual  or  threatened
solicitation of proxies or consents for the election or removal of directors.

     On March 24,  2009,  San Antonio  Fire & Police  Pension  Fund, a purported
stockholder  of the Company,  filed a class action lawsuit in the Delaware Court
of Chancery  against the Company and its  directors  seeking to disable the debt
acceleration provisions in the Notes and the Credit Agreement. On April 6, 2009,
San Antonio Fire & Police Pension Fund filed a Third Amended  Complaint  against
the  Company,  its  directors  and Bank of America,  N.A.  (the lead bank on the
Credit  Agreement),  alleging that the directors of the Company  violated  their
fiduciary duties by adopting the  acceleration  provisions in the 2007 Notes and
in the Credit  Agreement  and by failing  to  approve  the Icahn and  Eastbourne
nominees pursuant to the 2007 Indenture, that the acceleration provisions in the
Credit  Agreement are unlawful and invalid,  and that the Company's  disclosures
concerning the  acceleration  provisions are coercive and misleading.  The Icahn
Parties have moved to intervene as  individual  plaintiffs  in the lawsuit.  The
court has ordered  expedited  proceedings  in the lawsuit,  and has  scheduled a
trial for May 4 and 5, 2009.

ADDITIONAL INFORMATION

     Certain  information  regarding  the  securities of Amylin held by Amylin's
directors,  management  and 5%  Stockholders  is  contained  in  Amylin's  Proxy
Statement.  Information  concerning  the date by  which  proposals  of  security
holders  intended to be presented at the next annual meeting of  Stockholders of
Amylin must be received by Amylin for inclusion in Amylin's Proxy  Statement and
form of proxy for that meeting is also  contained in Amylin's  Proxy  Statement.
This  information is expected to be contained in Amylin's  public  filings.  The
Participants  take no  responsibility  for the accuracy or  completeness of such
information contained in Amylin's public filings.


Date:

                                            CARL C. ICAHN
                                            DR. ALEXANDER J. DENNER
                                            DR. THOMAS F. DEUEL
                                            MR. JULES HAIMOVITZ
                                            DR. PETER LIEBERT
                                            DR. DAVID SIDRANSKY
                                            ICAHN PARTNERS LP
                                            ICAHN PARTNERS MASTER FUND LP
                                            ICAHN PARTNERS MASTER FUND II LP
                                            ICAHN PARTNERS MASTER FUND III LP
                                            ICAHN ENTERPRISES G.P. INC.
                                            ICAHN ENTERPRISES HOLDINGS L.P.
                                            IPH GP LLC
                                            ICAHN CAPITAL L.P.
                                            ICAHN ONSHORE LP
                                            ICAHN OFFSHORE LP
                                            BECKTON CORP.





ANNEX A

BENEFICIAL OWNERSHIP OF SECURITIES OF AMYLIN

Beneficial  Ownership  by the Icahn  Parties of  Securities  of Amylin as of the
close of business on April 6, 2009:


(1)  Title of         (2)  Name of         (3) Amount and       (4) Percent of
     Class                 Beneficial          Nature of            Class (2)
                           Owner (1)           Beneficial
                                               Ownership


Common Stock, par          Icahn Partners       4,533,433             3.22%
value $0.001
per share
Common Stock, par          Icahn Master         5,592,721             3.97%
value $0.001
per share
Common Stock, par          Icahn Master II      2,057,967             1.46%
value $0.001
per share
Common Stock, par          Icahn Master III       787,207             0.56%
value $0.001
per share

____________________
(1)  Please note that each Record Holder listed in this table is, as of the date
     of this Notice,  the direct  beneficial owner of the Shares set forth under
     the  heading  "(3)  Amount  of  Beneficial  Ownership"  and  that  indirect
     beneficial ownership of Shares is described below in the text of this Annex
     A under the heading "Description of Beneficial Ownership."
(2)  Please note that  percentages  of  ownership  set forth in this column were
     calculated  based on the amount of Shares stated to be outstanding as March
     16, 2009 by the Company in the Company's Preliminary Proxy Statement.





INFORMATION ABOUT MR. ICAHN

     Mr.  Icahn has an  interest  in the  election  of  directors  at the Annual
Meeting indirectly through the beneficial ownership of securities,  as described
below.

Carl C. Icahn has served as  chairman  of the board and a director  of  Starfire
Holding Corporation ("Starfire"), a privately-held holding company, and chairman
of the board and a director of various  subsidiaries  of  Starfire,  since 1984.
Since August  2007,  through his  position as Chief  Executive  Officer of Icahn
Capital  LP,  a  wholly-owned  subsidiary  of  Icahn  Enterprises  L.P.  ("Icahn
Enterprises"), and certain related entities, Mr. Icahn's principal occupation is
managing private  investment funds,  including Icahn Partners LP, Icahn Partners
Master Fund LP, Icahn Partners Master Fund II LP, and Icahn Partners Master Fund
III LP. Prior to August 2007, Mr. Icahn  conducted this  occupation  through his
entities CCI Onshore Corp. and CCI Offshore  Corp.,  since November 2004.  Since
November  1990,  Mr. Icahn has been  chairman of the board of Icahn  Enterprises
G.P.  Inc., the general  partner of Icahn  Enterprises.  Icahn  Enterprises is a
diversified  holding  company  engaged  in a variety  of  businesses,  including
investment  management,  metals,  real estate,  and home fashion.  Mr. Icahn was
chairman  of the  board  and  president  of  Icahn  & Co.,  Inc.,  a  registered
broker-dealer  and a member of the National  Association of Securities  Dealers,
from 1968 to 2005.  Mr.  Icahn  has  served  as  chairman  of the board and as a
director of American  Railcar  Industries,  Inc.,  a company  that is  primarily
engaged in the business of manufacturing covered hopper and tank railcars, since
1994.  From  October 1998 through May 2004,  Mr. Icahn was the  president  and a
director of Stratosphere Corporation, the owner and operator of the Stratosphere
Hotel and Casino in Las Vegas,  which,  until February 2008, was a subsidiary of
Icahn Enterprises. From September 2000 to February 2007, Mr. Icahn served as the
chairman of the board of GB Holdings,  Inc., which owned an interest in Atlantic
Coast  Holdings,  Inc.,  the owner and  operator of The Sands casino in Atlantic
City until November 2006.  From September 2006 to November 2008, Mr. Icahn was a
director  of  ImClone  Systems  Incorporated  ("ImClone"),  a  biopharmaceutical
company,  and from  October  2006 to November  2008,  he was the chairman of the
board of ImClone.  Mr. Icahn has been chairman of the board and a director of XO
Holdings, Inc., a telecommunications services provider, since February 2006, and
of its predecessor from January 2003 to February 2006. Mr. Icahn has served as a
Director of Cadus Corporation,  a company engaged in the ownership and licensing
of  yeast-based  drug discovery  technologies  since July 1993. In May 2005, Mr.
Icahn became a director of Blockbuster  Inc., a provider of in-home movie rental
and game  entertainment.  In  October  2005,  Mr.  Icahn  became a  director  of
WestPoint  International,  Inc.,  a  manufacturer  of bed and bath home  fashion
products.  In August 2007, Mr. Icahn became a director of WCI Communities,  Inc.
("WCI"), a homebuilding company, and since September 2007, has been the chairman
of the  board  of WCI.  In  December  2007,  Mr.  Icahn  became  a  director  of
Federal-Mogul Corporation ("Federal-Mogul"),  a supplier of automotive products,
and since January 2008, has been the chairman of the board of Federal-Mogul.  In
April,  2008,  Mr.  Icahn became a director of  Motricity,  Inc., a company that
provides  mobile  content  services and  solutions.  In August,  2008, Mr. Icahn
became a director of Yahoo!  Inc., a company that provides  Internet services to
users, advertisers, publishers, and developers worldwide. Mr. Icahn received his
B.A. from Princeton University.

            DESCRIPTION OF BENEFICIAL OWNERSHIP AND BENEFICIAL OWNERS

     Beckton Corp., a Delaware  corporation  ("Beckton") is the sole stockholder
of Icahn Enterprises G.P. Inc., a Delaware corporation ("Icahn Enterprises GP"),
which is the general  partner of Icahn  Enterprises  Holdings  L.P.,  a Delaware
limited partnership ("Icahn Holdings"). Icahn Holdings is the sole member of IPH
GP LLC, a Delaware  limited  liability  company  ("IPH"),  which is the  general
partner of Icahn Capital L.P., a Delaware limited partnership ("Icahn Capital").
Icahn  Capital is the  general  partner of each of Icahn  Onshore LP, a Delaware
limited  partnership ("Icahn Onshore") and Icahn Offshore LP, a Delaware limited
partnership  ("Icahn  Offshore").  Icahn Onshore is the general partner of Icahn
Partners.  Icahn Offshore is the general partner of each of Icahn Master,  Icahn
Master II and Icahn  Master III.  Beckton is 100 percent  owned by Carl C. Icahn
("Mr.  Icahn," and  collectively  with  Beckton,  Icahn  Enterprises  GP,  Icahn
Holdings,  IPH, Icahn Capital,  Icahn Onshore,  Icahn Offshore,  the "Beneficial
Owners"  and  each of them a  "Beneficial  Owner."  As such,  Mr.  Icahn is in a
position  indirectly to determine the  investment  and voting  decisions made by
each of the Icahn Parties.

     The  principal  business  address  of each  of (i)  Icahn  Offshore,  Icahn
Onshore, Icahn Capital, IPH, Icahn Holdings, Icahn Enterprises GP and Beckton is
White Plains Plaza, 445 Hamilton Avenue - Suite 1210, White Plains, NY 10601 and
(ii) Mr. Icahn is c/o Icahn Capital LP., 767 Fifth Avenue, 47th Floor, New York,
NY 10153.

     Icahn  Offshore  is  primarily  engaged in the  business  of serving as the
general  partner of each of Icahn Master,  Icahn Master II and Icahn Master III.
Icahn  Onshore is  primarily  engaged in the  business of serving as the general
partner of Icahn Partners. Icahn Capital is primarily engaged in the business of
serving as the general partner of each of Icahn Offshore and Icahn Onshore.  IPH
is primarily  engaged in the business of serving as the general partner of Icahn
Capital.  Icahn Holdings is primarily  engaged in the business of holding direct
or indirect interests in various operating  businesses.  Icahn Enterprises GP is
primarily  engaged in the business of serving as the general  partner of each of
Icahn  Enterprises  and Icahn  Holdings.  Beckton  is  primarily  engaged in the
business of holding the capital stock of Icahn Enterprises GP.

     The Icahn Parties and Carl C. Icahn may be deemed to  beneficially  own, in
the  aggregate,  12,971,328  shares,  representing  approximately  9.21%  of the
Corporation's outstanding Shares (based upon the 140,840,515 Shares stated to be
outstanding  as of March 16,  2009 by the Company in the  Company's  Preliminary
Proxy Statement).

     Icahn Partners has sole voting power and sole dispositive power with regard
to 4,533,433 Shares. Each of Icahn Onshore,  Icahn Capital, IPH, Icahn Holdings,
Icahn  Enterprises  GP, Beckton and Mr. Icahn has shared voting power and shared
dispositive power with regard to such Shares. Icahn Master has sole voting power
and sole  dispositive  power  with  regard to  5,592,721  Shares.  Each of Icahn
Offshore,  Icahn Capital, IPH, Icahn Holdings, Icahn Enterprises GP, Beckton and
Mr. Icahn has shared  voting power and shared  dispositive  power with regard to
such Shares.  Icahn Master II has sole voting power and sole  dispositive  power
with regard to 2,057,967  Shares.  Each of Icahn Offshore,  Icahn Capital,  IPH,
Icahn  Holdings,  Icahn  Enterprises GP, Beckton and Mr. Icahn has shared voting
power and shared dispositive power with regard to such Shares.  Icahn Master III
has sole voting power and sole dispositive  power with regard to 787,207 Shares.
Each of Icahn Offshore,  Icahn Capital,  IPH, Icahn Holdings,  Icahn Enterprises
GP, Beckton and Mr. Icahn has shared voting power and shared  dispositive  power
with regard to such Shares.

     Each  of  Icahn  Onshore,   Icahn  Capital,  IPH,  Icahn  Holdings,   Icahn
Enterprises GP, Beckton and Mr. Icahn, by virtue of their relationships to Icahn
Partners,  may be deemed to indirectly  beneficially  own the  4,533,433  Shares
which Icahn Partners directly  beneficially owns. Each of Icahn Offshore,  Icahn
Capital,  IPH, Icahn Holdings,  Icahn  Enterprises GP, Beckton and Mr. Icahn, by
virtue of their relationships to Icahn Master,  Icahn Master II and Icahn Master
III, may be deemed to indirectly  beneficially  own the  8,437,895  Shares which
Icahn Master, Icahn Master II and Icahn Master III directly beneficially own.


                             TWO YEAR SUMMARY TABLE:

The following table  indicates the date of each purchase and sale of Shares,  as
well as the exercise of any call options,  by Mr. Icahn and his  affiliates  and
Dr. Peter  Liebert  within the past two years,  and the number of shares in each
such purchase and sale or call option exercise.


                                                            SHARES PURCHASED/
                                                            (SOLD) AND CALL
NAME                                       DATE             OPTIONS EXERCISED
- ----                                       ----             --------------------
High River Limited Partnership           7/25/2007               100,000
High River Limited Partnership           7/26/2007                40,120
High River Limited Partnership           7/27/2007                98,480
High River Limited Partnership           7/30/2007                46,260
High River Limited Partnership           7/31/2007                66,620
High River Limited Partnership            8/1/2007                23,160
High River Limited Partnership            8/2/2007                 8,940
High River Limited Partnership           8/30/2007               (23,422)
High River Limited Partnership           8/31/2007               (29,169)
High River Limited Partnership            9/4/2007               (44,070)
High River Limited Partnership            9/5/2007                (3,339)
High River Limited Partnership            9/5/2007               (40,120)
High River Limited Partnership            9/5/2007               (30,701)
High River Limited Partnership            9/6/2007               (45,040)
High River Limited Partnership           9/10/2007               (22,739)
High River Limited Partnership           9/10/2007                (4,661)
High River Limited Partnership           9/11/2007               (11,860)
High River Limited Partnership           9/12/2007                (9,640)
High River Limited Partnership           9/14/2007               (20,099)
High River Limited Partnership           9/14/2007               (31,901)
High River Limited Partnership           9/19/2007               (34,719)
High River Limited Partnership           9/19/2007               (23,160)
High River Limited Partnership           9/19/2007                (2,648)
High River Limited Partnership           9/20/2007                  (440)
High River Limited Partnership           9/21/2007                (5,852)
Icahn Partners LP                        7/25/2007               128,314
Icahn Partners LP                        7/26/2007                51,480
Icahn Partners LP                        7/27/2007               126,375
Icahn Partners LP                        7/30/2007                59,360
Icahn Partners LP                        7/31/2007                85,487
Icahn Partners LP                         8/1/2007                30,678
Icahn Partners LP                         8/2/2007                11,494
Icahn Partners LP                        8/30/2007               (30,061)
Icahn Partners LP                        8/31/2007               (37,509)
Icahn Partners LP                         9/4/2007               (31,854)
Icahn Partners LP                         9/5/2007               (28,890)
Icahn Partners LP                         9/5/2007               (51,480)
Icahn Partners LP                         9/5/2007               (21,408)
Icahn Partners LP                         9/6/2007               (61,836)
Icahn Partners LP                        9/10/2007               (37,599)
Icahn Partners LP                        9/11/2007                (5,532)
Icahn Partners LP                        9/11/2007               (10,743)
Icahn Partners LP                        9/12/2007               (13,229)
Icahn Partners LP                        9/14/2007               (35,388)
Icahn Partners LP                        9/14/2007               (35,962)
Icahn Partners LP                        9/19/2007               (49,525)
Icahn Partners LP                        9/19/2007               (30,678)
Icahn Partners LP                        9/19/2007                (2,861)
Icahn Partners LP                        9/20/2007                  (604)
Icahn Partners LP                        9/21/2007                (8,029)
Icahn Partners LP                        1/31/2008                78,865
Icahn Partners LP                         2/1/2008                93,018
Icahn Partners LP                         2/6/2008                47,847
Icahn Partners LP                         2/6/2008                 1,000
Icahn Partners LP                         2/7/2008               139,515
Icahn Partners LP                         2/8/2008               105,839
Icahn Partners LP                        2/11/2008                18,701
Icahn Partners LP                        2/12/2008               279,088
Icahn Partners LP                        2/13/2008                20,644
Icahn Partners LP                        2/14/2008                74,798
Icahn Partners LP                        2/15/2008               139,401
Icahn Partners LP                        2/19/2008               127,271
Icahn Partners LP                        2/20/2008                74,798
Icahn Partners LP                        2/21/2008                59,838
Icahn Partners LP                        2/22/2008                75,398
Icahn Partners LP                        2/25/2008                44,958
Icahn Partners LP                        2/27/2008               261,809
Icahn Partners LP                        2/28/2008                74,802
Icahn Partners LP                        2/29/2008                88,492
Icahn Partners LP                         3/3/2008               127,470
Icahn Partners LP                         3/4/2008               104,261
Icahn Partners LP                         3/5/2008               128,713
Icahn Partners LP                         3/6/2008               113,739
Icahn Partners LP                        3/10/2008               122,505
Icahn Partners LP                        3/11/2008                56,870
Icahn Partners LP                        3/13/2008                36,598
Icahn Partners LP                         9/9/2008                37,584
Icahn Partners LP                        9/11/2008               888,670(3)
Icahn Partners LP                        9/11/2008               358,423(4)
Icahn Partners LP                        9/25/2008                57,919
Icahn Partners LP                        9/26/2008               141,749
Icahn Partners LP                        9/29/2008                37,599
Icahn Partners LP                        9/30/2008                11,906
Icahn Partners LP                        10/3/2008                47,767
Icahn Partners LP                        1/29/2009               145,314
Icahn Partners LP                        1/30/2009               273,846
Icahn Partners LP                         2/2/2009                36,418

____________________
(3)  Icahn  Partners  acquired  these  Shares upon  exercise of call  options as
     described on Attachment I-A to this Annex A.
(4)  The Icahn  Partners  acquired these Shares upon exercise of call options as
     described on Attachment I-B to this Annex A.





                                                            SHARES PURCHASED/
                                                            (SOLD) AND CALL
NAME                                       DATE             OPTIONS EXERCISED
- ----                                       ----             --------------------
Icahn Partners Master Fund LP            7/25/2007               187,201
Icahn Partners Master Fund LP            7/26/2007                75,105
Icahn Partners Master Fund LP            7/27/2007               184,357
Icahn Partners Master Fund LP            7/30/2007                86,600
Icahn Partners Master Fund LP            7/31/2007               124,713
Icahn Partners Master Fund LP             8/1/2007                41,253
Icahn Partners Master Fund LP             8/2/2007                16,685
Icahn Partners Master Fund LP            8/30/2007               (43,783)
Icahn Partners Master Fund LP            8/31/2007               (54,438)
Icahn Partners Master Fund LP             9/4/2007               (88,980)
Icahn Partners Master Fund LP             9/4/2007               (10,409)
Icahn Partners Master Fund LP             9/5/2007               (64,696)
Icahn Partners Master Fund LP             9/5/2007               (69,270)
Icahn Partners Master Fund LP             9/6/2007               (81,361)
Icahn Partners Master Fund LP            9/10/2007               (33,726)
Icahn Partners Master Fund LP            9/10/2007               (15,771)
Icahn Partners Master Fund LP            9/11/2007               (21,424)
Icahn Partners Master Fund LP            9/12/2007               (17,415)
Icahn Partners Master Fund LP            9/14/2007               (31,990)
Icahn Partners Master Fund LP            9/14/2007               (61,964)
Icahn Partners Master Fund LP            9/19/2007               (62,749)
Icahn Partners Master Fund LP            9/19/2007               (41,253)
Icahn Partners Master Fund LP            9/19/2007                (5,324)
Icahn Partners Master Fund LP            9/20/2007                  (794)
Icahn Partners Master Fund LP            9/21/2007               (10,567)
Icahn Partners Master Fund LP            1/31/2008                91,252
Icahn Partners Master Fund LP             2/1/2008               109,421
Icahn Partners Master Fund LP             2/6/2008                56,565
Icahn Partners Master Fund LP             2/6/2008                 1,000
Icahn Partners Master Fund LP             2/7/2008               163,220
Icahn Partners Master Fund LP             2/8/2008               123,826
Icahn Partners Master Fund LP            2/11/2008                21,876
Icahn Partners Master Fund LP            2/12/2008               326,512
Icahn Partners Master Fund LP            2/13/2008                24,153
Icahn Partners Master Fund LP            2/14/2008                87,509
Icahn Partners Master Fund LP            2/15/2008               163,089
Icahn Partners Master Fund LP            2/19/2008               148,895
Icahn Partners Master Fund LP            2/20/2008                87,508
Icahn Partners Master Fund LP            2/21/2008                70,006
Icahn Partners Master Fund LP            2/22/2008                88,210
Icahn Partners Master Fund LP            2/25/2008                52,465
Icahn Partners Master Fund LP            2/27/2008               306,273
Icahn Partners Master Fund LP            2/28/2008                87,506
Icahn Partners Master Fund LP            2/29/2008               103,521
Icahn Partners Master Fund LP             3/3/2008                76,164
Icahn Partners Master Fund LP             3/4/2008               118,033
Icahn Partners Master Fund LP             3/5/2008               145,718
Icahn Partners Master Fund LP             3/6/2008               128,762
Icahn Partners Master Fund LP             9/9/2008                43,023
Icahn Partners Master Fund LP            9/11/2008             1,027,533(5)
Icahn Partners Master Fund LP            9/11/2008               431,466(6)
Icahn Partners Master Fund LP            9/11/2008               244,502(7)
Icahn Partners Master Fund LP            9/25/2008                63,488
Icahn Partners Master Fund LP            9/26/2008               162,155
Icahn Partners Master Fund LP            9/29/2008                43,012
Icahn Partners Master Fund LP            9/30/2008                13,621
Icahn Partners Master Fund LP            10/1/2008                23,123
Icahn Partners Master Fund LP            10/3/2008                70,374
Icahn Partners Master Fund LP            11/6/2008               115,198
Icahn Partners Master Fund LP            11/7/2008               362,790
Icahn Partners Master Fund LP            1/29/2009                49,301
Icahn Partners Master Fund LP            1/30/2009               339,204
Icahn Partners Master Fund LP             2/2/2009                22,447

____________________
(5)  The Icahn Master  acquired  these  Shares upon  exercise of call options as
     described on Attachment I-A to this Annex A.
(6)  Icahn  Master  acquired  these  Shares  upon  exercise  of call  options as
     described on Attachment I-B to this Annex A.
(7)  Icahn  Master  acquired  these  Shares  upon  exercise  of call  options as
     described on Attachment I-C to this Annex A.





                                                            SHARES PURCHASED/
                                                            (SOLD) AND CALL
NAME                                       DATE             OPTIONS EXERCISED
- ----                                       ----             --------------------
Icahn Partners Master Fund II L.P.       7/25/2007                61,247
Icahn Partners Master Fund II L.P.       7/26/2007                24,573
Icahn Partners Master Fund II L.P.       7/27/2007                60,308
Icahn Partners Master Fund II L.P.       7/30/2007                28,331
Icahn Partners Master Fund II L.P.       7/31/2007                40,802
Icahn Partners Master Fund II L.P.        8/1/2007                15,176
Icahn Partners Master Fund II L.P.        8/2/2007                 5,500
Icahn Partners Master Fund II L.P.       8/30/2007               (14,404)
Icahn Partners Master Fund II L.P.       8/31/2007               (17,941)
Icahn Partners Master Fund II L.P.        9/4/2007               (28,902)
Icahn Partners Master Fund II L.P.        9/4/2007                (3,768)
Icahn Partners Master Fund II L.P.        9/5/2007               (20,805)
Icahn Partners Master Fund II L.P.        9/5/2007               (23,373)
Icahn Partners Master Fund II L.P.        9/6/2007               (26,810)
Icahn Partners Master Fund II L.P.       9/10/2007               (10,125)
Icahn Partners Master Fund II L.P.       9/10/2007                (6,201)
Icahn Partners Master Fund II L.P.       9/11/2007                (7,068)
Icahn Partners Master Fund II L.P.       9/12/2007                (5,743)
Icahn Partners Master Fund II L.P.       9/14/2007                (9,319)
Icahn Partners Master Fund II L.P.       9/14/2007               (21,653)
Icahn Partners Master Fund II L.P.       9/19/2007               (19,149)
Icahn Partners Master Fund II L.P.       9/19/2007               (15,176)
Icahn Partners Master Fund II L.P.       9/19/2007                (1,750)
Icahn Partners Master Fund II L.P.       9/20/2007                  (263)
Icahn Partners Master Fund II L.P.       9/21/2007                (3,487)
Icahn Partners Master Fund II L.P.       1/31/2008                28,921
Icahn Partners Master Fund II L.P.        2/1/2008                33,747
Icahn Partners Master Fund II L.P.        2/6/2008                16,971
Icahn Partners Master Fund II L.P.        2/6/2008                 1,000
Icahn Partners Master Fund II L.P.        2/7/2008                50,969
Icahn Partners Master Fund II L.P.        2/8/2008                38,665
Icahn Partners Master Fund II L.P.       2/11/2008                 6,831
Icahn Partners Master Fund II L.P.       2/12/2008               101,959
Icahn Partners Master Fund II L.P.       2/13/2008                 7,542
Icahn Partners Master Fund II L.P.       2/14/2008                27,326
Icahn Partners Master Fund II L.P.       2/15/2008                50,927
Icahn Partners Master Fund II L.P.       2/19/2008                46,495
Icahn Partners Master Fund II L.P.       2/20/2008                27,326
Icahn Partners Master Fund II L.P.       2/21/2008                21,861
Icahn Partners Master Fund II L.P.       2/22/2008                27,545
Icahn Partners Master Fund II L.P.       2/25/2008                16,370
Icahn Partners Master Fund II L.P.       2/27/2008                95,636
Icahn Partners Master Fund II L.P.       2/28/2008                27,324
Icahn Partners Master Fund II L.P.       2/29/2008                32,325
Icahn Partners Master Fund II L.P.        3/3/2008                48,284
Icahn Partners Master Fund II L.P.        3/4/2008                38,177
Icahn Partners Master Fund II L.P.        3/5/2008                47,132
Icahn Partners Master Fund II L.P.        3/6/2008                41,649
Icahn Partners Master Fund II L.P.       3/10/2008                44,859
Icahn Partners Master Fund II L.P.       3/11/2008                20,824
Icahn Partners Master Fund II L.P.       3/13/2008                13,401
Icahn Partners Master Fund II L.P.       5/12/2008                36,399
Icahn Partners Master Fund II L.P.       5/13/2008                86,327
Icahn Partners Master Fund II L.P.       5/14/2008                67,854
Icahn Partners Master Fund II L.P.       5/15/2008                79,781
Icahn Partners Master Fund II L.P.       5/21/2008                40,431
Icahn Partners Master Fund II L.P.       5/22/2008                13,819
Icahn Partners Master Fund II L.P.        9/9/2008                14,052
Icahn Partners Master Fund II L.P.       9/11/2008                 8,769(8)
Icahn Partners Master Fund II L.P.       9/11/2008               152,160(9)
Icahn Partners Master Fund II L.P.       9/25/2008                20,703
Icahn Partners Master Fund II L.P.       9/26/2008                52,964
Icahn Partners Master Fund II L.P.       9/29/2008                14,048
Icahn Partners Master Fund II L.P.       9/30/2008                 4,449
Icahn Partners Master Fund II L.P.       10/1/2008                13,413
Icahn Partners Master Fund II L.P.       10/3/2008                23,076
Icahn Partners Master Fund II L.P.       11/7/2008                25,022
Icahn Partners Master Fund II L.P.       1/29/2009               365,314
Icahn Partners Master Fund II L.P.       1/30/2009               125,320

____________________
(8)  Icahn  Master II acquired  these  Shares upon  exercise of call  options as
     described on Attachment I-A to this Annex A.
(9)  Icahn  Master II acquired  these  Shares upon  exercise of call  options as
     described on Attachment I-B to this Annex A.





                                                            SHARES PURCHASED/
                                                            (SOLD) AND CALL
NAME                                       DATE             OPTIONS EXERCISED
- ----                                       ----             --------------------
Icahn Partners Master Fund III L.P       7/25/2007                23,238
Icahn Partners Master Fund III L.P       7/26/2007                 9,322
Icahn Partners Master Fund III L.P       7/27/2007                22,880
Icahn Partners Master Fund III L.P       7/30/2007                10,749
Icahn Partners Master Fund III L.P       7/31/2007                15,478
Icahn Partners Master Fund III L.P        8/1/2007                 5,533
Icahn Partners Master Fund III L.P        8/2/2007                 2,081
Icahn Partners Master Fund III L.P       8/30/2007                (5,440)
Icahn Partners Master Fund III L.P       8/31/2007                (6,790)
Icahn Partners Master Fund III L.P        9/4/2007               (11,008)
Icahn Partners Master Fund III L.P        9/4/2007                (1,362)
Icahn Partners Master Fund III L.P        9/5/2007                (7,960)
Icahn Partners Master Fund III L.P        9/5/2007                (8,758)
Icahn Partners Master Fund III L.P        9/6/2007               (10,153)
Icahn Partners Master Fund III L.P       9/10/2007                (3,969)
Icahn Partners Master Fund III L.P       9/10/2007                (2,209)
Icahn Partners Master Fund III L.P       9/11/2007                (2,673)
Icahn Partners Master Fund III L.P       9/12/2007                (2,173)
Icahn Partners Master Fund III L.P       9/14/2007                (3,694)
Icahn Partners Master Fund III L.P       9/14/2007                (8,030)
Icahn Partners Master Fund III L.P       9/19/2007                (7,448)
Icahn Partners Master Fund III L.P       9/19/2007                (5,533)
Icahn Partners Master Fund III L.P       9/19/2007                  (663)
Icahn Partners Master Fund III L.P       9/20/2007                   (99)
Icahn Partners Master Fund III L.P       9/21/2007                (1,319)
Icahn Partners Master Fund III L.P.      1/31/2008                10,962
Icahn Partners Master Fund III L.P.       2/1/2008                12,814
Icahn Partners Master Fund III L.P.       2/6/2008                 5,817
Icahn Partners Master Fund III L.P.       2/6/2008                 1,000
Icahn Partners Master Fund III L.P.       2/7/2008                19,336
Icahn Partners Master Fund III L.P.       2/8/2008                14,670
Icahn Partners Master Fund III L.P.      2/11/2008                 2,592
Icahn Partners Master Fund III L.P.      2/12/2008                38,681
Icahn Partners Master Fund III L.P.      2/13/2008                 2,861
Icahn Partners Master Fund III L.P.      2/14/2008                10,367
Icahn Partners Master Fund III L.P.      2/15/2008                19,321
Icahn Partners Master Fund III L.P.      2/19/2008                17,639
Icahn Partners Master Fund III L.P.      2/20/2008                10,368
Icahn Partners Master Fund III L.P.      2/21/2008                 8,295
Icahn Partners Master Fund III L.P.      2/22/2008                10,447
Icahn Partners Master Fund III L.P.      2/25/2008                 6,207
Icahn Partners Master Fund III L.P.      2/27/2008                36,282
Icahn Partners Master Fund III L.P.      2/28/2008                10,368
Icahn Partners Master Fund III L.P.      2/29/2008                12,262
Icahn Partners Master Fund III L.P.       3/3/2008                19,164
Icahn Partners Master Fund III L.P.       3/4/2008                14,529
Icahn Partners Master Fund III L.P.       3/5/2008                17,937
Icahn Partners Master Fund III L.P.       3/6/2008                15,850
Icahn Partners Master Fund III L.P.      3/10/2008                17,072
Icahn Partners Master Fund III L.P.      3/11/2008                 7,924
Icahn Partners Master Fund III L.P.      3/13/2008                 5,100
Icahn Partners Master Fund III L.P.      5/12/2008                13,835
Icahn Partners Master Fund III L.P.      5/13/2008                32,813
Icahn Partners Master Fund III L.P.      5/14/2008                25,794
Icahn Partners Master Fund III L.P.      5/15/2008                30,324
Icahn Partners Master Fund III L.P.      5/21/2008                15,228
Icahn Partners Master Fund III L.P.      5/22/2008                 5,391
Icahn Partners Master Fund III L.P.       9/9/2008                 5,341
Icahn Partners Master Fund III L.P.      9/11/2008                 2,796(10)
Icahn Partners Master Fund III L.P.      9/11/2008                57,951(11)
Icahn Partners Master Fund III L.P.      9/25/2008                 7,890
Icahn Partners Master Fund III L.P.      9/26/2008                20,132
Icahn Partners Master Fund III L.P.      9/29/2008                 5,341
Icahn Partners Master Fund III L.P.      9/30/2008                 1,691
Icahn Partners Master Fund III L.P.      10/1/2008                 5,837
Icahn Partners Master Fund III L.P.      10/3/2008                 8,783
Icahn Partners Master Fund III L.P.      11/7/2008                12,188
Icahn Partners Master Fund III L.P.      1/29/2009               140,071
Icahn Partners Master Fund III L.P.      1/30/2009                47,936
Dr. Peter Liebert                         2/9/2009                 1,000
Dr. Peter Liebert                        2/10/2009                 1,000

____________________
(10) Icahn  Master III acquired  these  Shares upon  exercise of call options as
     described on Attachment I-A to this Annex A.
(11) Icahn  Master III acquired  these  Shares upon  exercise of call options as
     described on Attachment I-B to this Annex A.





Shares  purchased by each of the Icahn Parties are maintained in margin accounts
that include  positions in securities in addition to the Shares.  As of [ ], the
indebtedness  of the margin  account of each of Icahn  Partners,  Icahn  Master,
Icahn  Master  II and  Icahn  Master  III was  approximately  $,  $,  $,  and $,
respectively.





                                                                         ANNEX A
                                                                  ATTACHMENT 1-A

The following are American call options  purchased by the Icahn  Parties,  which
were written by Merrill  Lynch  International  with a $22.50 strike price and an
expiration  date of March 10, 2010,  and which provide for physical  settlement.
These are further described in the chart set forth below. On September 11, 2008,
the Icahn  Parties  exercised  all of the call  options  described  in the chart
below.


                                                     NUMBER OF
                                                     SHARES SUBJECT
NAME                                   DATE          TO OPTION          PREMIUM
- ----                                   ----          ---------          -------

Icahn Partners LP                    5/12/2008        98,799          680,665.83
Icahn Partners LP                    5/12/2008         7,565           51,729.47
Icahn Partners LP                    5/13/2008       234,322        1,562,646.55
Icahn Partners LP                    5/14/2008       184,122        1,307,487.15
Icahn Partners LP                    5/15/2008       216,614        1,705,965.22
Icahn Partners LP                    5/21/2008       109,365          910,113.66
Icahn Partners LP                    5/22/2008        37,883          317,648.96
Icahn Partners Master Fund LP        5/12/2008       112,467          774,830.15
Icahn Partners Master Fund LP        5/12/2008        24,534          167,763.49
Icahn Partners Master Fund LP        5/13/2008       266,738        1,778,822.37
Icahn Partners Master Fund LP        5/14/2008       209,729        1,489,327.57
Icahn Partners Master Fund LP        5/15/2008       246,446        1,940,910.12
Icahn Partners Master Fund LP        5/21/2008       124,712        1,037,828.32
Icahn Partners Master Fund LP        5/22/2008        42,907          359,775.20
Icahn Partners Master Fund II L.P.   5/12/2008         8,769           59,962.42
Icahn Partners Master Fund III, L.P. 5/12/2008         2,796           19,119.05





                                                                         ANNEX A
                                                                  ATTACHMENT 1-B

The following are American call options  purchased by the Icahn  Parties,  which
were written by Merrill  Lynch  International  with a $14.25 strike price and an
expiration date of September 7, 2010, and which provide for physical settlement.
These are further described in the chart set forth below. On September 11, 2008,
the Icahn  Parties  exercised  all of the call  options  described  in the chart
below.

                                                     NUMBER OF
                                                     SHARES SUBJECT
NAME                                   DATE          TO OPTION          PREMIUM
- ----                                   ----          ---------          -------

Icahn Partners LP                    9/2/2008        302,048        2,254,697.71
Icahn Partners LP                    9/3/2008         56,375          418,477.26
Icahn Partners Master Fund LP        9/2/2008        366,932        2,739,037.30
Icahn Partners Master Fund LP        9/3/2008         64,534          479,042.34
Icahn Partners Master Fund II L.P.   9/2/2008        131,081          978,480.34
Icahn Partners Master Fund II L.P.   9/3/2008         21,079          156,471.52
Icahn Partners Master Fund III L.P.  9/2/2008         49,939          372,779.65
Icahn Partners Master Fund III L.P.  9/3/2008          8,012           59,473.88





                                                                         ANNEX A
                                                                  ATTACHMENT 1-C

The following are American call options  purchased by the Icahn  Parties,  which
were  written by UBS AG with a $16.15  strike  price and an  expiration  date of
September 7, 2010, and which provide for physical settlement.  These are further
described in the chart set forth below. On September 11, 2008, the Icahn Parties
exercised all of the call options described in the chart below.

                                                     NUMBER OF
                                                     SHARES SUBJECT
NAME                                   DATE          TO OPTION          PREMIUM
- ----                                   ----          ---------          -------

Icahn Partners Master Fund LP        3/10/2008       138,688        1,164,798.91
Icahn Partners Master Fund LP        3/11/2008        64,382          517,792.23
Icahn Partners Master Fund LP        3/13/2008        41,432          359,563.47





                                                                         ANNEX A
                                                                  ATTACHMENT 1-D

The following are European put options bought by the Icahn  Parties,  which were
written by Merrill  Lynch  International  and have a $22.50  strike price and an
expiration  date of March 10, 2010, and provide for cash settlement only and are
further described in the chart set forth below. On September 11, 2008, the Icahn
Parties  exercised all of the call options  described in Annex A Attachment 1-A,
and upon exercise of the call options,  all of the put options  described  below
expired pursuant to their terms.


                                                                     OPTION
NAME                                   DATE          QUANTITY        PREMIUM ($)
- ----                                   ----          --------        -----------

Icahn Partners LP                    5/12/2008        98,799              987.99
Icahn Partners LP                    5/12/2008         7,565               75.65
Icahn Partners LP                    5/13/2008       234,322            2,343.22
Icahn Partners LP                    5/14/2008       184,122            1,841.22
Icahn Partners LP                    5/15/2008       216,614            2,166.14
Icahn Partners LP                    5/21/2008       109,365            1,093.65
Icahn Partners LP                    5/22/2008        37,883              378.83
Icahn Partners Master Fund LP        5/12/2008       112,467            1,124.67
Icahn Partners Master Fund LP        5/12/2008        24,534              245.34
Icahn Partners Master Fund LP        5/13/2008       266,738            2,667.38
Icahn Partners Master Fund LP        5/14/2008       209,729            2,097.29
Icahn Partners Master Fund LP        5/15/2008       246,446            2,464.46
Icahn Partners Master Fund LP        5/21/2008       124,712            1,247.12
Icahn Partners Master Fund LP        5/22/2008        42,907              429.07
Icahn Partners Master Fund II L.P.   5/12/2008         8,769               87.69
Icahn Partners Master Fund III, L.P. 5/12/2008         2,796               27.96





                                                                         ANNEX A
                                                                  ATTACHMENT 1-E

The following are European put options bought by the Icahn  Parties,  which were
written by Merrill  Lynch  International  and have a $14.25  strike price and an
expiration  date of September 7, 2010 and provide for cash  settlement  only and
are further  described in the chart set forth below.  On September 11, 2008, the
Icahn Parties exercised all of the call options described in Annex A Attachments
1-B, and upon  exercise of the call  options,  all of the put options  described
below expired pursuant to their terms.


                                                                     OPTION
NAME                                   DATE          QUANTITY        PREMIUM ($)
- ----                                   ----          --------        -----------

Icahn Partners LP                    9/2/2008        302,048            3,020.48
Icahn Partners LP                    9/3/2008         56,375              563.75
Icahn Partners Master Fund LP        9/2/2008        366,932            3,669.32
Icahn Partners Master Fund LP        9/3/2008         64,534              645.34
Icahn Partners Master Fund II L.P.   9/2/2008        131,081            1,310.81
Icahn Partners Master Fund II L.P.   9/3/2008         21,079              210.79
Icahn Partners Master Fund III, L.P. 9/2/2008         49,939              499.39
Icahn Partners Master Fund III, L.P. 9/3/2008          8,012               80.12





                                                                         ANNEX A
                                                                  ATTACHMENT 1-F

The following are European put options bought by the Icahn  Parties,  which were
written by UBS AG and have a $16.15 strike price and an expiration date of March
10, 2010 and provide for cash settlement  only and are further  described in the
chart set forth below. On September 11, 2008, the Icahn Parties exercised all of
the call options  described in Annex A Attachments 1-C, and upon exercise of the
call options,  all of the put options  described below expired pursuant to their
terms.


                                                                     OPTION
NAME                                   DATE          QUANTITY        PREMIUM ($)
- ----                                   ----          --------        -----------

Icahn Partners Master Fund LP        3/10/2008       138,688            1,386.88
Icahn Partners Master Fund LP        3/11/2008        64,382              643.82
Icahn Partners Master Fund LP        3/13/2008        41,432              414.32





                                                                         ANNEX B

                           [FORM OF NOMINEE AGREEMENT]

                                ICAHN PARTNERS LP
                          ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                        ICAHN PARTNERS MASTER FUND III LP

                                                     January 28, 2009

[NAME OF NOMINEE]


Dear  ___________:

     This will confirm our understanding as follows:

     You agree that you are willing, should we so elect, to become a member of a
slate of nominees  (the  "Slate") to stand for  election as  directors of Amylin
Pharmaceuticals,  Inc.  ("Amylin")  in  connection  with a  proxy  contest  with
management  of Amylin in respect of the  election of  directors of Amylin at the
2009 Annual Meeting of Stockholders of Amylin (the "Annual  Meeting"),  expected
to be held in the Spring of 2009, or a special meeting of stockholders of Amylin
called for a similar purpose (the "Proxy Contest").

     Icahn  Partners LP, Icahn Partners  Master Fund LP, Icahn  Partners  Master
Fund II LP and Icahn Partners Master Fund III LP (collectively,  "Icahn"), agree
to pay the costs of the Proxy Contest.

     In addition, upon our filing of a preliminary proxy statement with the SEC,
which  indicates  that Icahn  intends to nominate you for election at the Annual
Meeting,  you will be paid $25,000 by Icahn unless you are elected to serve as a
director of Amylin at the Annual Meeting or a special meeting of stockholders of
Amylin called for a similar  purpose or in  connection  with a settlement of the
Proxy  Contest  by Icahn and  Amylin,  in which  case you will not  receive  any
payment from Icahn in connection with the Proxy Contest. Payment to you pursuant
to this paragraph,  if any, will be made by Icahn,  subject to the terms hereof,
upon the  earliest of (i) the  certification  of the results of the  election in
respect of the Proxy Contest,  (ii) the settlement of the Proxy Contest by Icahn
and Amylin, or (iii) the withdrawal of the Proxy Contest by Icahn.*

     You  understand  that it may be difficult,  if not  impossible,  to replace
nominees  who,  such as  yourself,  have  agreed to serve on the Slate and later
change their minds and determine not to seek election. Accordingly, the Slate is
relying upon your agreement to seek election. In that connection,  you are being
supplied with a questionnaire  in which you will provide Icahn with  information
necessary for Icahn to make appropriate disclosure both to Amylin and for use in
creating the proxy material to be sent to stockholders of Amylin and to be filed
with the Securities and Exchange  Commission.  You have agreed that (i) you will
immediately  complete and sign the  questionnaire and return it to Tara Keating,
Assistant General Counsel,  Icahn Enterprises LP, 767 Fifth Avenue,  Suite 4700,
New  York,  NY  10153,  Tel:  (212)  702-4365,   Fax:  (212)  688-1158,   Email:
tkeating@sfire.com  and (ii) your responses to the questions  contained  therein
will be true and correct in all  respects.  In  addition,  you have agreed that,
concurrently  with your execution of this letter,  you will execute the attached
instrument  directed  to  Amylin  informing  Amylin  that you  consent  to being
nominated by Icahn for election as a director of Amylin and, if elected, consent
to serving as a director of Amylin. Upon being notified that we have chosen you,
we may forward  that  consent and your  completed  questionnaire  (or  summaries
thereof) to Amylin.

____________________
*    This paragraph is not contained in Dr. Denner's Nominee Agreement.





     Icahn hereby agrees that, so long as you actually serve on the Slate, Icahn
will  defend,  indemnify  and hold you  harmless  from and  against  any and all
losses, damages, penalties,  judgments, awards, liabilities, costs, expenses and
disbursements (including, without limitation, reasonable attorneys' fees, costs,
expenses and  disbursements)  incurred by you in the event that (i) you become a
party,  or  are  threatened  to  be  made  a  party,  to  any  civil,  criminal,
administrative or arbitrative action, suit or proceeding, and any appeal thereof
relating solely to your role as a nominee for director of Amylin on the Slate (a
"Proceeding")  or (ii) you are  called to testify  or give a  deposition  in any
Proceeding  (whether or not you are a party or are threatened to be made a party
to such  Proceeding),  including,  in each case,  the  advancement to you of all
reasonable  attorneys' costs and expenses incurred by you in connection with any
Proceeding.  Your right of  indemnification  hereunder shall continue (i) in the
event that Icahn  determines  to withdraw the Slate or remove you from the Slate
and (ii) after the  election  has taken  place but only for events  which  occur
prior to such  election  and  subsequent  to the date  hereof.  Anything  to the
contrary herein  notwithstanding,  Icahn is not  indemnifying you for any action
taken  by you or on your  behalf  which  occurs  prior  to the  date  hereof  or
subsequent  to the Annual  Meeting or such  earlier  time as you are no longer a
nominee of the Slate for  election to  Amylin's  Board of  Directors  or for any
actions taken by you as a director of Amylin, if you are elected. Nothing herein
shall be construed to provide you an  indemnity:  (i) in the event you are found
to have  engaged in a  violation  of any  provision  of state or federal  law in
connection  with the Proxy Contest unless you  demonstrate  that your action was
taken in good  faith and in a manner  you  reasonably  believed  to be in or not
opposed to the best  interests of electing the Slate;  or (ii) if you acted in a
manner which  constitutes gross negligence or willful  misconduct.  In the event
that you shall make any claim for indemnification  hereunder, you shall promptly
notify Icahn in the event of any third-party claims actually made against you or
known by you to be  threatened.  In  addition,  with  respect to any such claim,
Icahn shall be entitled to control your  defense  with counsel  chosen by Icahn.
Icahn  shall not be  responsible  for any  settlement  of any claim  against you
covered by this indemnity without its prior written consent.  However, Icahn may
not enter into any settlement of any such claim without your consent unless such
settlement  includes a release of you from any and all  liability  in respect of
such claim.

     Each of us recognizes  that should you be elected to the Board of Directors
of Amylin all of your activities and decisions as a director will be governed by
applicable law and subject to your fiduciary duty to the  stockholders of Amylin
and, as a result,  that there is, and can be, no agreement between you and Icahn
which governs the decisions which you will make as a director of Amylin.

     Should the foregoing agree with your  understanding,  please so indicate in
the space provided below,  whereupon this letter will become a binding agreement
between us.

                                            Very truly yours,

                                            ICAHN PARTNERS LP


                                            By: __________________________
                                                Name: Edward E. Mattner
                                                Title: Authorized Signatory

                                            ICAHN PARTNERS MASTER FUND LP


                                            By: __________________________
                                                Name: Edward E. Mattner
                                                Title: Authorized Signatory

                                            ICAHN PARTNERS MASTER FUND II LP


                                            By: __________________________
                                                Name: Edward E. Mattner
                                                Title: Authorized Signatory

                                            ICAHN PARTNERS MASTER FUND III LP


                                            By: __________________________
                                                Name: Edward E. Mattner
                                                Title: Authorized Signatory


Agreed to and Accepted as
of the date first above written:



- --------------------------
Name:





                                    IMPORTANT
                                    ---------

     1. If your shares are held in your own name, please mark, date and mail the
enclosed GOLD proxy card to our Proxy  Solicitor,  D.F. King & Co., Inc., in the
postage-paid envelope provided.

     2. If your shares are held in the name of a brokerage firm, bank nominee or
other  institution,  only it can vote such shares and only upon  receipt of your
specific  instructions.  Accordingly,  you should contact the person responsible
for your  account  and give  instructions  for a GOLD  proxy  card to be  signed
representing your shares.

     3. If you have  already  submitted  a white  proxy  card to Amylin  for the
Annual  Meeting,  you may  change  your vote to a vote FOR the  election  of the
Nominee by marking,  signing,  dating and returning the enclosed GOLD proxy card
for the  Annual  Meeting,  which  must be dated  after  any  proxy  you may have
submitted  to Amylin.  You may also submit your  later-dated  proxy by using the
enclosed  GOLD proxy card to vote by telephone or by Internet.  ONLY YOUR LATEST
DATED PROXY FOR THE ANNUAL MEETING WILL COUNT AT THE ANNUAL MEETING.

     If you have any  questions  or require any  assistance  in  executing  your
proxy, please call:

                              D.F. KING & CO., INC.
                   STOCKHOLDERS CALL TOLL-FREE: (800) 488-8075
                 BANKS AND BROKERAGE FIRMS CALL: (212) 269-5550