PROXY CARD [PRELIMINARY COPY] AMYLIN PHARMACEUTICALS, INC. ANNUAL MEETING OF STOCKHOLDERS [ ], 2009 GOLD PROXY CARD GOLD PROXY CARD THIS PROXY IS SOLICITED BY: ICAHN PARTNERS LP ICAHN PARTNERS MASTER FUND LP ICAHN PARTNERS MASTER FUND II LP ICAHN PARTNERS MASTER FUND III LP VOTE BY INTERNET VOTE BY TELEPHONE VOTE BY MAIL [ ] [ ] Have this form available Call toll-free on a touch-tone Mark, date and sign when you visit the secure phone, 24 hours a day, seven this voting direc- voting site and follow the days a week. Have this form tion form and mail simple instructions. You may available when you call and promptly in the elect to receive an e-mail follow the simple instructions. postage-paid envel- confirmation of your vote. ope. Do not return the card if you vote by telephone or by Internet. YOUR VOTE, WHETHER BY INTERNET, TELEPHONE OR MAIL, MUST BE RECEIVED NO LATER THAN [ ] PM, EASTERN TIME, ON [ ], TO BE INCLUDED IN THE VOTING RESULTS. The undersigned hereby appoints and constitutes each of Alexander J. Denner and Mayu Sris (acting alone or together) as proxies, with full power of substitution in each, to represent the undersigned at the Annual Meeting of Stockholders of Amylin Pharmaceuticals, Inc. ("Amylin") to be held on [ ]at [ ]local time, and at any adjournment or postponement or continuations thereof (the "Annual Meeting"), hereby revoking any proxies previously given, to vote all shares of Common Stock of Amylin held or owned by the undersigned as directed below, and in their discretion upon such other matters as may come before the meeting (provided, however, that the persons named above will be permitted to use such discretionary authority only for matters which they do not know, a reasonable time before the solicitation, are to be presented at the meeting). IF NO DIRECTION IS MADE, THE PERSONS NAMED IN THIS GOLD PROXY CARD WILL VOTE YOUR SHARES: FOR DR. ALEXANDER J. DENNER, DR. THOMAS F. DEUEL, MR. JULES HAIMOVITZ, DR. PETER LIEBERT AND DR. DAVID SIDRANSKY FOR DIRECTOR; FOR THE PERSONS WHO HAVE BEEN NOMINATED BY AMYLIN TO SERVE AS DIRECTORS, OTHER THAN [ ] (V) FOR PROPOSALS [ ]; AND AGAINST PROPOSALS [ ]. SIGN, DATE AND MAIL YOUR PROXY TODAY (CONTINUED AND TO BE SIGNED ON THE REVERSE SIDE.) ICAHN PARTNERS, ICAHN MASTER, ICAHN MASTER II, AND ICAHN MASTER III EACH RECOMMEND A VOTE "FOR" THE ELECTION OF THE NOMINEES LISTED IN PROPOSAL 1 BELOW, "FOR" PROPOSALS [ ], AND "AGAINST PROPOSALS [ ]. [PRELIMINARY COPY] [X] PLEASE MARK VOTES AS IN THIS EXAMPLE. STOCKHOLDERS ARE URGED TO DATE, MARK, SIGN, AND RETURN THIS PROXY. YOUR VOTE IS VERY IMPORTANT TO US. 1. Election of directors -- Nominees: [ ] [ ] [ ] (01) Dr. Alexander J. Denner FOR ALL WITHHELD FOR ALL (02) Dr. Thomas F. Deuel NOMINEES FROM ALL EXCEPT (03) Mr. Jules Haimovitz NOMINEES (04) Dr. Peter Liebert (05) Dr. David Sidransky The persons who have been nominated by Amylin to serve as directors, other than The Icahn Parties are NOT seeking authority to vote for and WILL NOT exercise any authority to vote for [ ]. There is no assurance that any of the Amylin nominees will serve as directors if any or all of the Icahn Parties' nominees are elected to the Board. You should refer to the proxy statement and form of proxy distributed by Amylin for the names, background, qualifications and other information concerning the Amylin nominees. NOTE: IF YOU DO NOT WISH YOUR SHARES VOTED "FOR" A PARTICULAR NOMINEE, MARK THE "FOR ALL EXCEPT" BOX AND WRITE THE NAME(S) OF THE NOMINEE(S) YOU DO NOT SUPPORT ON THE LINE BELOW. YOU MAY ALSO WITHHOLD AUTHORITY TO VOTE FOR THE PERSONS WHO HAVE BEEN NOMINATED BY AMYLIN TO SERVE AS DIRECTORS OTHER THAN [ ] BY WRITING THE NAMES OF SUCH NOMINEES BELOW. YOUR SHARES WILL BE VOTED FOR THE REMAINING NOMINEE(S). - ------------------------------------------------------------------------------- 2. North Dakota Reincorporation Proposal [ ] [ ] [ ] FOR AGAINST ABSTAIN 3. Amylin's 2009 Equity Incentive Plan [ ] [ ] [ ] FOR AGAINST ABSTAIN 4. Amendment to the 2001 Employee Stock [ ] [ ] [ ] Purchase Plan FOR AGAINST ABSTAIN 5. Ratification of appointment of Independent [ ] [ ] [ ] Registered Public Accounting Firm FOR AGAINST ABSTAIN Please be sure to sign and date this Proxy. ----------------------------------------------------------- ------------ SIGNATURE(S) OF STOCKHOLDER(S) DATE ----------------------------------------------------------- ------------ SIGNATURE(S) IF HELD JOINTLY -------------------------------------------------------------------------- TITLE, IF ANY