PROXY CARD [PRELIMINARY COPY]
                          AMYLIN PHARMACEUTICALS, INC.
                         ANNUAL MEETING OF STOCKHOLDERS
                                    [ ], 2009
GOLD PROXY CARD                                                  GOLD PROXY CARD
                           THIS PROXY IS SOLICITED BY:
                                ICAHN PARTNERS LP
                          ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                        ICAHN PARTNERS MASTER FUND III LP

VOTE BY INTERNET                  VOTE BY TELEPHONE                 VOTE BY MAIL
       [ ]                               [ ]
Have this form available     Call toll-free on a touch-tone  Mark, date and sign
when you visit the secure    phone, 24 hours a day, seven    this voting direc-
voting site and follow the   days a week.  Have this form    tion form and mail
simple instructions. You may available when you call and     promptly in the
elect to receive an e-mail   follow the simple instructions. postage-paid envel-
confirmation of your vote.                                   ope. Do not return
                                                             the card if you
                                                             vote by telephone
                                                             or by Internet.

                  YOUR VOTE, WHETHER BY INTERNET, TELEPHONE OR
                     MAIL, MUST BE RECEIVED NO LATER THAN [ ]
                    PM, EASTERN TIME, ON [ ], TO BE INCLUDED
                             IN THE VOTING RESULTS.

The undersigned  hereby appoints and constitutes each of Alexander J. Denner and
Mayu Sris (acting alone or together) as proxies, with full power of substitution
in each, to represent the  undersigned at the Annual Meeting of  Stockholders of
Amylin  Pharmaceuticals,  Inc. ("Amylin") to be held on [ ]at [ ]local time, and
at any  adjournment  or  postponement  or  continuations  thereof  (the  "Annual
Meeting"),  hereby revoking any proxies  previously given, to vote all shares of
Common Stock of Amylin held or owned by the undersigned as directed  below,  and
in their  discretion  upon such  other  matters as may come  before the  meeting
(provided,  however,  that the persons named above will be permitted to use such
discretionary  authority  only for matters  which they do not know, a reasonable
time before the solicitation, are to be presented at the meeting).

     IF NO  DIRECTION  IS MADE,  THE PERSONS  NAMED IN THIS GOLD PROXY CARD WILL
     VOTE YOUR SHARES:  FOR DR.  ALEXANDER J. DENNER,  DR. THOMAS F. DEUEL,  MR.
     JULES  HAIMOVITZ,  DR. PETER LIEBERT AND DR. DAVID  SIDRANSKY FOR DIRECTOR;
     FOR THE PERSONS WHO HAVE BEEN  NOMINATED  BY AMYLIN TO SERVE AS  DIRECTORS,
     OTHER THAN [ ] (V) FOR PROPOSALS [ ]; AND AGAINST PROPOSALS [ ].


                      SIGN, DATE AND MAIL YOUR PROXY TODAY
                (CONTINUED AND TO BE SIGNED ON THE REVERSE SIDE.)





ICAHN  PARTNERS,  ICAHN  MASTER,  ICAHN  MASTER  II,  AND ICAHN  MASTER III EACH
RECOMMEND A VOTE "FOR" THE ELECTION OF THE NOMINEES  LISTED IN PROPOSAL 1 BELOW,
"FOR" PROPOSALS [ ], AND "AGAINST PROPOSALS [ ]. [PRELIMINARY COPY]

[X] PLEASE MARK VOTES AS IN THIS EXAMPLE.

    STOCKHOLDERS ARE URGED TO DATE, MARK, SIGN, AND RETURN THIS PROXY.

    YOUR VOTE IS VERY IMPORTANT TO US.

1.  Election of directors -- Nominees:   [ ]        [ ]           [ ]
    (01) Dr. Alexander J. Denner         FOR ALL    WITHHELD      FOR ALL
    (02) Dr. Thomas F. Deuel             NOMINEES   FROM ALL      EXCEPT
    (03) Mr. Jules Haimovitz                        NOMINEES
    (04) Dr. Peter Liebert
    (05) Dr. David Sidransky
    The persons who have been nominated by Amylin to serve as directors, other
    than

    The Icahn  Parties are NOT seeking  authority  to vote for and WILL NOT
    exercise any authority to vote for [ ]. There is no assurance  that any
    of the Amylin  nominees  will serve as  directors  if any or all of the
    Icahn Parties'  nominees are elected to the Board.  You should refer to
    the proxy  statement  and form of proxy  distributed  by Amylin for the
    names, background,  qualifications and other information concerning the
    Amylin nominees.

    NOTE: IF YOU DO NOT WISH YOUR SHARES VOTED "FOR" A PARTICULAR  NOMINEE,
    MARK THE "FOR ALL EXCEPT"  BOX AND WRITE THE NAME(S) OF THE  NOMINEE(S)
    YOU DO NOT SUPPORT ON THE LINE BELOW.  YOU MAY ALSO WITHHOLD  AUTHORITY
    TO VOTE FOR THE PERSONS WHO HAVE BEEN  NOMINATED  BY AMYLIN TO SERVE AS
    DIRECTORS  OTHER THAN [ ] BY WRITING THE NAMES OF SUCH NOMINEES  BELOW.
    YOUR SHARES WILL BE VOTED FOR THE REMAINING NOMINEE(S).

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2.  North Dakota Reincorporation Proposal          [ ]     [ ]        [ ]
                                                   FOR     AGAINST    ABSTAIN


3.  Amylin's 2009 Equity Incentive Plan            [ ]     [ ]        [ ]
                                                   FOR     AGAINST    ABSTAIN


4.  Amendment to the 2001 Employee Stock           [ ]     [ ]        [ ]
    Purchase Plan                                  FOR     AGAINST    ABSTAIN


5.  Ratification of appointment of Independent     [ ]     [ ]        [ ]
    Registered Public Accounting Firm              FOR     AGAINST    ABSTAIN



    Please be sure to sign and date this Proxy.


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               SIGNATURE(S) OF STOCKHOLDER(S)                       DATE

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               SIGNATURE(S) IF HELD JOINTLY



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