For Immediate Release                                       Contact Susan Gordon
April 15, 2009                                                      212 702-4309

     New York, New York  (AMLN:NASDAQ).  Carl Icahn  announced today that he had
sent the  following  letter to Joseph C.  Cook,  Jr.,  Chairman  of the Board of
Amylin  Pharmaceutical,  Inc. concerning the election of directors to take place
at the forthcoming annual meeting of Amylin's stockholders:

                                                     April 15, 2009

Mr. Joseph C. Cook, Jr.
Chairman of the Board
Amylin Pharmaceuticals, Inc.
9360 Towne Centre Drive
San Diego, CA 92121

Dear Mr. Cook:

     Amylin is a prime example of what is wrong with the corporate governance of
most American public companies.

     We agree with you that the board of Amylin should  change.  However,  three
major stockholders of Amylin, namely Eastbourne,  ourselves and,  significantly,
Ted Greene - Amylin's  co-founder,  all agree  that the  obvious  choice for the
first director to leave Amylin's board is you. You have been the Chairman and/or
CEO  during  the time  that an  enormous  amount of  stockholder  value has been
destroyed and for reasons,  described  below, a flawed  strategy has existed for
far too long. Removing Ted Green (Amylin's co-founder) and Ginger Graham (former
CEO) rather than you seems like a manifestation  of what we believe is the "cult
of personality" which has adversely affected Amylin.

     Like an "imperial"  chairman you have taken steps to entrench yourself that
we believe to be unconscionable. You not only have the poison pill but your 2007
indenture  has a poison  put and your 2007  credit  agreement  has an even worse
poison  put.  In  addition,  as a  direct  result  of your  poison  pill,  large
stockholders  of  Amylin,   such  as  my  entities,   may  not  have  meaningful
conversations  with  other  large  stockholders  such  as  Eastbourne.  Even  in
DICTATORSHIPS  dissidents are allowed to COMMUNICATE with each other. But not at
Amylin.

     Several  months  ago,  I  informed  you that  based on our status as one of
Amylin's  largest  stockholders  and based  upon the  experiences  that I and my
suggested  nominees had in ImClone  Systems,  I believed it would be in Amylin's
best  interest  to give these  nominees  representation  on Amylin's  board.  My
nominees  and I were  proactive  in the  enhancement  of  stockholder  value  at
ImClone.  AS YOU MAY BE AWARE,  AFTER I WAS  ELECTED  TO THE BOARD OF IMCLONE IN
OCTOBER 2006,  ITS PER SHARE MARKET VALUE  INCREASED BY 135% THROUGH ITS SALE IN
LATE 2008. IT IS INTERESTING TO NOTE THAT, IN DIRECT  CONTRAST,  DURING THE SAME
PERIOD  AMYLIN'S  PER SHARE MARKET  VALUE  DECLINED IN VALUE BY 85%.  Given that
Amylin  is  flailing,  as is  evident  from the  market  for its  shares,  it is
ludicrous and arrogant for you to contend that my highly qualified nominees, who
were among those  responsible for such wonderful  results at ImClone,  cannot be
beneficial to Amylin. Additionally,  it is even more absurd and irresponsible to
enter into a "debilitating" proxy fight to keep my nominees,  who are proven and
knowledgeable individuals, off the board.

     Around  the same time that I asked  you for board  representation,  another
large  stockholder,  Eastbourne,  also informed you it was dissatisfied with the
way you were operating the company and wished to have its representatives placed
on the  board.  It also  informed  you it  would  like the  Icahn  group to have
representation.  In our subsequent discussions, I informed you that I would like
Eastbourne,  as well as some of my  nominees,  to be  represented  on the board.
While you have stated to us that a proxy fight would be  "debilitating"  for the
company you have steadfastly refused to allow Eastbourne and us to meet with you
TOGETHER to discuss just how to avoid the "debilitating"  proxy fight.  Further,
your  poison  pill  prevents  Eastbourne  and the Icahn  group  from  having any
constructive dialogue with each other.

     Having  two major  stockholders  both  independently  decide to run a proxy
fight against the same board is rare - it  dramatically  shows how  stockholders
have  lost  faith  in  the  Amylin's   board's   ability  to  run  the  company.
Additionally,  it is  also  almost  unheard  of,  at the  same  time,  to have a
co-founder and director of the company resign and express his  displeasure  with
your stewardship.

     How could it NOT be in the best interest of Amylin and its  stockholders to
allow a dialogue to begin among Eastbourne,  the Icahn group and the company? We
could immediately enter into discussions on how to end TWO "debilitating"  proxy
fights,  and more importantly,  how to enhance  stockholder value in other ways.
With all due respect,  Amylin,  under your  stewardship,  has made many grievous
mistakes.  For example,  Amylin never should have  undertaken to spend  enormous
amounts  of money to  maintain a large  commercial  operation  in  primary  care
diabetes sales --- an absurd commercial effort for a small biotech company. (Had
we been on the board of  Amylin  when its deal with  Lilly was  consummated,  we
would have fought for a royalty paying  arrangement with an option to co-promote
Byetta - an arrangement  that could possibly have caused Amylin to have positive
cash flow  today.)  SG&A has been made too high at Amylin in part as a result of
the  primary-care  sales  force,  and in part because  management  and the board
allowed it to happen.  Amylin's SG&A is approximately 47% of sales compared with
other similar biotech  companies(1)  whose median SG&A is approximately  22%. As
directors,  my  nominees  would seek to have  Amylin  renegotiate  with Lilly to
change their  commercial  agreement.  In  addition,  we believe that the company
should  engage  experts  to advise on how to reduce  the  amount of money  being
wasted at Amylin. However, at the risk of being facetious, I wouldn't be opposed
to making  expenditures  to discover an antidote  for  Amylin's  poison pill and
poison puts. I look forward to your response.

                                                     Sincerely,


                                                     /s/ Carl Icahn
                                                     --------------
_________________________
(1)  As reported by Amgen Inc., Celgene  Corporation,  Genentech Inc. and Gilead
     Sciences, Inc. for the fiscal year ended 2008.

SECURITY  HOLDERS ARE ADVISED TO READ THE PROXY  STATEMENT  AND OTHER  DOCUMENTS
RELATED TO THE  SOLICITATION  OF  PROXIES BY CARL C.  ICAHN,  DR.  ALEXANDER  J.
DENNER, DR. THOMAS F. DEUEL, MR. JULES HAIMOVITZ,  DR. PETER LIEBERT,  DR. DAVID
SIDRANSKY, MR. MAYU SRIS, MR. JEFFREY MECKLER, MR. ERIC ENDE, ICAHN PARTNERS LP,
ICAHN PARTNERS  MASTER FUND LP, ICAHN PARTNERS MASTER FUND II LP, ICAHN PARTNERS
MASTER FUND III LP, ICAHN  ENTERPRISES  G.P. INC.,  ICAHN  ENTERPRISES  HOLDINGS
L.P.,  IPH GP LLC,  ICAHN  CAPITAL L.P.,  ICAHN  ONSHORE LP, ICAHN  OFFSHORE LP,
BECKTON CORP., AND CERTAIN OF THEIR RESPECTIVE  AFFILIATES FROM THE STOCKHOLDERS
OF AMYLIN  PHARMACEUTICALS,  INC, FOR USE AT ITS ANNUAL MEETING WHEN THEY BECOME
AVAILABLE,   BECAUSE  THEY  WILL  CONTAIN   IMPORTANT   INFORMATION,   INCLUDING
INFORMATION  RELATING TO THE PARTICIPANTS IN ANY SUCH PROXY  SOLICITATION.  WHEN
COMPLETED, A DEFINITIVE PROXY STATEMENT AND A FORM OF PROXY WILL BE AVAILABLE TO
STOCKHOLDERS OF AMYLIN PHARMACEUTICALS,  INC. FROM THE PARTICIPANTS AT NO CHARGE
AND  WILL  ALSO  BE  AVAILABLE  AT NO  CHARGE  AT THE  SECURITIES  AND  EXCHANGE
COMMISSION'S WEBSITE AT HTTP://WWW.SEC.GOV.

INFORMATION RELATING TO THE PARTICIPANTS IN THIS PROXY SOLICITATION IS CONTAINED
IN  SCHEDULE  14A FILED BY MR.  ICAHN AND  CERTAIN  OF HIS  AFFILIATES  WITH THE
SECURITIES  AND  EXCHANGE  COMMISSION  ON JANUARY 30,  2009,  WHICH  DOCUMENT IS
AVAILABLE AT NO CHARGE AT THE SECURITIES  AND EXCHANGE  COMMISSION' S WEBSITE AT
HTTP://WWW.SEC.GOV.