SCHEDULE 14A
                    Proxy Statement Pursuant to Section 14(a)
            of the Securities Exchange Act of 1934 (Amendment No. __)


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     Rule 14a-6(e)(2))
[ ]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[X]  Soliciting Material Pursuant to ss. 240.14a-12

                          Amylin Pharmaceuticals, Inc.
                (Name of Registrant as Specified In Its Charter)

                                  CARL C. ICAHN
                             DR. ALEXANDER J. DENNER
                               DR. THOMAS F. DEUEL
                               MR. JULES HAIMOVITZ
                                DR. PETER LIEBERT
                               DR. DAVID SIDRANSKY
                                  MR. MAYU SRIS
                               MR. JEFFREY MECKLER
                                  DR. ERIC ENDE
                                ICAHN PARTNERS LP
                          ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                        ICAHN PARTNERS MASTER FUND III LP
                           ICAHN ENTERPRISES G.P. INC.
                         ICAHN ENTERPRISES HOLDINGS L.P.
                                   IPH GP LLC
                               ICAHN CAPITAL L.P.
                                ICAHN ONSHORE LP
                                ICAHN OFFSHORE LP
                                  BECKTON CORP.
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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On April 23,  2009,  Carl  Icahn  issued a press  release  in the form  included
herewith which contains the full text of a letter to Mr. James Wilson, which was
transmitted  by Mr.  Icahn to Mr.  Wilson  prior to the  issuance  of the  press
release.


For Immediate Release                                       Contact Susan Gordon
April 23, 2009                                                      212 702-4309

             Icahn asks Amylin to allow discussions with Eastbourne

New York, New York.  Carl Icahn  announced  today that he had sent the following
letter to James Wilson,  Lead  Independent  Director of Amylin  Pharmaceuticals,
Inc. (AMLN:NASDAQ).

                                                     April 23, 2009


Mr. James Wilson
Lead Independent Director
Amylin Pharmaceuticals, Inc.
9360 Towne Centre Drive
San Diego, CA  92121

Dear Jim:

If you are really serious about settling what you consider a debilitating  proxy
contest, I believe it is mandatory for you to take the necessary action to allow
Eastbourne and myself to talk without the threat of your poison pill and Section
203 preventing  these  discussions.  It is almost absurd that I and  Eastbourne,
separately,  have had to ask you a number of times during last week and the week
before  to get  permission  to  have  these  talks.  As I have  said,  even in a
dictatorship parties that disagree with the ruling regime are allowed to talk to
each other. But not at Amylin.

I  sincerely  believe  that as a result  of  these  discussions  and  subsequent
discussions among the three of us, there will be enough common ground to resolve
the matter.  What exactly are you afraid of? The  alternative is for the Company
and its  stockholders to continue to be distracted  because of the  inexplicable
intransigence of the current Board which continues to evidence itself in so many
ways,  e.g. the poison pill,  the poison puts, and the failure to heed the views
of your co-founder, Howard E. Greene, Jr., regarding Joseph Cook's board seat.

I look forward to your prompt response.

                                                     Sincerely,

                                                     Carl Icahn


SECURITY  HOLDERS ARE ADVISED TO READ THE PROXY  STATEMENT  AND OTHER  DOCUMENTS
RELATED TO THE  SOLICITATION  OF  PROXIES BY CARL C.  ICAHN,  DR.  ALEXANDER  J.
DENNER, DR. THOMAS F. DEUEL, MR. JULES HAIMOVITZ,  DR. PETER LIEBERT,  DR. DAVID
SIDRANSKY, MR. MAYU SRIS, MR. JEFFREY MECKLER, DR. ERIC ENDE, ICAHN PARTNERS LP,
ICAHN PARTNERS  MASTER FUND LP, ICAHN PARTNERS MASTER FUND II LP, ICAHN PARTNERS
MASTER FUND III LP, ICAHN  ENTERPRISES  G.P. INC.,  ICAHN  ENTERPRISES  HOLDINGS
L.P.,  IPH GP LLC,  ICAHN  CAPITAL L.P.,  ICAHN  ONSHORE LP, ICAHN  OFFSHORE LP,
BECKTON CORP., AND CERTAIN OF THEIR RESPECTIVE  AFFILIATES FROM THE STOCKHOLDERS
OF AMYLIN  PHARMACEUTICALS,  INC, FOR USE AT ITS ANNUAL MEETING WHEN THEY BECOME
AVAILABLE,   BECAUSE  THEY  WILL  CONTAIN   IMPORTANT   INFORMATION,   INCLUDING
INFORMATION  RELATING TO THE PARTICIPANTS IN ANY SUCH PROXY  SOLICITATION.  WHEN
COMPLETED, A DEFINITIVE PROXY STATEMENT AND A FORM OF PROXY WILL BE AVAILABLE TO
STOCKHOLDERS OF AMYLIN PHARMACEUTICALS,  INC. FROM THE PARTICIPANTS AT NO CHARGE
AND  WILL  ALSO  BE  AVAILABLE  AT NO  CHARGE  AT THE  SECURITIES  AND  EXCHANGE
COMMISSION'S WEBSITE AT HTTP://WWW.SEC.GOV.

INFORMATION RELATING TO THE PARTICIPANTS IN THIS PROXY SOLICITATION IS CONTAINED
IN SCHEDULE  14A FILED BY THE  PARTICIPANTS  WITH THE  SECURITIES  AND  EXCHANGE
COMMISSION,  WHICH  DOCUMENTS ARE AVAILABLE AT NO CHARGE AT THE  SECURITIES  AND
EXCHANGE COMMISSION'S WEBSITE AT HTTP://WWW.SEC.GOV.