SCHEDULE 14A
                    Proxy Statement Pursuant to Section 14(a)
            of the Securities Exchange Act of 1934 (Amendment No. 1)



Filed by the Registrant                     [ ]

Filed by a Party other than the Registrant  [x]

Check the appropriate box:

[X]  Preliminary Proxy Statement
[ ]  Confidential, for Use of the Commission Only (as permitted by
     Rule 14a-6(e)(2))
[ ]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to ss. 240.14a-12

                          AMYLIN PHARMACEUTICALS, INC.
                (Name of Registrant as Specified In Its Charter)


                                  CARL C. ICAHN
                             DR. ALEXANDER J. DENNER
                               DR. THOMAS F. DEUEL
                                DR. PETER LIEBERT
                                    MAYU SRIS
                                 JEFFREY MECKLER
                                  DR. ERIC ENDE
                                ICAHN PARTNERS LP
                          ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                        ICAHN PARTNERS MASTER FUND III LP
                           ICAHN ENTERPRISES G.P. INC.
                         ICAHN ENTERPRISES HOLDINGS L.P.
                                   IPH GP LLC
                               ICAHN CAPITAL L.P.
                                ICAHN ONSHORE LP
                                ICAHN OFFSHORE LP
                                  BECKTON CORP.
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of Filing Fee (check the appropriate box):

[X] No fee required.

[ ] Fee computed on table below per Exchange Act Rule 14a-6(i)(4) and 0-11.

    1) Title of each class of securities to which transaction applies:

    2) Aggregate number of securities to which transaction applies:

    3) Per unit price or other  underlying  value of  transaction  computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee
is calculated and state how it was determined):

    4) Proposed maximum aggregate value of transaction:

    5) Total fee paid:

[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided  by  Exchange  Act
    Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was
    paid  previously.  Identify the previous filing by  registration  statement
    number, or the Form or Schedule and the date of its filing.

    1) Amount Previously Paid:

    2) Form, Schedule or Registration Statement No.:

    3) Filing Party:

    4) Date Filed:





                       2009 ANNUAL MEETING OF STOCKHOLDERS

                                       OF

                          AMYLIN PHARMACEUTICALS, INC.

                               -------------------

                                 PROXY STATEMENT
                               [PRELIMINARY COPY]
                                       OF


                                  CARL C. ICAHN
                             DR. ALEXANDER J. DENNER
                               DR. THOMAS F. DEUEL
                                DR. PETER LIEBERT
                                    MAYU SRIS
                                 JEFFREY MECKLER
                                  DR. ERIC ENDE
                                ICAHN PARTNERS LP
                          ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                        ICAHN PARTNERS MASTER FUND III LP
                           ICAHN ENTERPRISES G.P. INC.
                         ICAHN ENTERPRISES HOLDINGS L.P.
                                   IPH GP LLC
                               ICAHN CAPITAL L.P.
                                ICAHN ONSHORE LP
                                ICAHN OFFSHORE LP
                                  BECKTON CORP.


                               -------------------

To Our Fellow Amylin Stockholders:


     This  Proxy  Statement  and the  accompanying  GOLD  proxy  card are  being
furnished  to  stockholders  ("Stockholders")  of Amylin  Pharmaceuticals,  Inc.
("Amylin,"  "Corporation"  or "Company") in connection with the  solicitation of
proxies by Carl C. Icahn and the  Participants (as hereinafter  defined),  to be
used at the 2009 Annual Meeting (the "Annual Meeting") of Stockholders of Amylin
which is scheduled to be held at 8:30 a.m., local time, on May 27, 2009, at 4575
Eastgate Mall, San Diego, CA 92121,  and at any  adjournments,  postponements or
continuations  thereof.  This Proxy  Statement and the GOLD proxy card are first
being furnished to Stockholders on or about [ ].

     At the Annual Meeting,  the Participants (as hereinafter defined) will seek
to elect to the Board of  Directors  ("Board") of Amylin the  following  persons
(each a "Nominee" and collectively, the "Nominees"):

                             Dr. Alexander J. Denner
                               Dr. Thomas F. Deuel
                                Dr. Peter Liebert

     Each of our Nominees has  consented to being named in this Proxy  Statement
and, if elected, to serve as a director.

     Under the proxy rules as written we are required  either to solicit proxies
only  for  our  Nominees,   which  would  result  in  limiting  the  ability  of
Stockholders to fully exercise their voting rights to vote for a full complement
of directors,  or, alternatively,  to solicit proxies in support of our Nominees
and also to seek  authority  from  Stockholders  to vote  for all of the  Amylin
nominees  other  than  those  Amylin  nominees  we  specify,   which  enables  a
Stockholder  who  desires  to vote  for a full  complement  of  twelve  director
nominees to use the GOLD proxy card to vote for our  Nominees as well as for all
or some of those of the Amylin  nominees  for whom we are seeking  authority  to
vote. However, we sought and obtained from the staff ("Staff") of the Securities
and  Exchange  Commission's  ("Commission")  Division of  Corporation  Finance a
no-action  letter  dated March 30,  2009,  which  states that the Staff will not
recommend that the Commission  take any  enforcement  action should we provide a
proxy  card  which  seeks  authority  from  Stockholders  to vote  for:  (i) our
Nominees; (ii) Eastbourne's nominees other than those nominees we specify on our
GOLD proxy  card;  and (iii)  Amylin's  nominees  other than those  nominees  we
specify on our GOLD proxy card and, in each case,  other than those  nominees as
to which the Stockholder  specifically  withholds our authority to vote for. The
no-action  letter  is  not  binding  on  the  Commission  and  contains  certain
conditions  we believe we will meet.  Therefore,  although we indicated  that we
were going to nominate five persons as directors at the annual meeting,  we have
determined to nominate a slate of three such persons,  Dr. Denner, Dr. Deuel and
Dr. Liebert and are seeking authority to vote for all of the Eastbourne  Capital
Management,  L.L.C.  ("Eastbourne")  nominees  other than  Marina S.  Bozilenko,
Charles M.  Fleischman and William A. Nuerge and all of Amylin's  nominees other
than Joseph C. Cook, Jr., James R. Gavin III, Jay S. Skyler,  Joseph P. Sullivan
and James N. Wilson.  As a result,  should a Stockholder so authorize us, on the
GOLD proxy  card,  we would cast votes for our three  Nominees,  two  Eastbourne
nominees and seven Amylin nominees.  None of such Eastbourne  nominees or Amylin
nominees for whom we seek authority to vote have agreed to serve with any of our
Nominees, if elected.  Additionally, if Eastbourne or Amylin do not nominate the
respective  individuals for which we seek authority to vote, our GOLD proxy card
will not allow such  Stockholder to utilize the GOLD proxy card to vote for such
individual.  If such  event  occurs  we  reserve  our  right to amend  our proxy
materials to allow for the vote for a full complement of twelve directors.

     At the Annual Meeting, the Icahn Parties (as hereinafter defined) will also
introduce  a  resolution  to ask the Board of Amylin to  promptly  initiate  and
complete the  necessary  and  appropriate  process so that the  Stockholders  of
Amylin can choose whether to change Amylin's  jurisdiction of incorporation from
Delaware  to North  Dakota and to become  subject to the North  Dakota  Publicly
Traded Corporations Act (the "North Dakota Reincorporation  Proposal"). See "the
North Dakota Reincorporation Proposal," below.

     Section  5(a)(iii) of the  Company's  Fourth  Amended and Restated  By-Laws
provides that business may be brought  before an annual meeting by a stockholder
who was a stockholder of record at the time the stockholder  gave advance notice
of its intention to bring the business before the meeting. The Icahn Parties (as
hereinafter  defined) gave such notice on January 30, 2009,  with respect to the
North Dakota Reincorporation Proposal ("Reincorporation Proposal").

     The  North  Dakota  Reincorporation  Proposal  requires  for  adoption  the
affirmative  vote of the holders of a majority of the Common  Stock  present and
voting on the  Proposal.  However,  if adopted the  Proposal is not binding upon
Amylin's Board.  Nonetheless,  the Board will know that the Stockholders support
the  concept of the North  Dakota  Reincorporation  Proposal  and would urge the
Board to take such action.

     THE PARTICIPANTS  URGE YOU TO VOTE THE GOLD PROXY CARD FOR DR. ALEXANDER J.
DENNER,  DR.  THOMAS F. DEUEL AND DR. PETER  LIEBERT AS DIRECTORS  AND THE ICAHN
PARTIES URGE YOU TO VOTE FOR THE NORTH DAKOTA REINCORPORATION PROPOSAL.

     The Nominees and each of the other  Participants have no interest in Amylin
other than through the beneficial  ownership (if any) of shares of Common Stock,
par value $.001 per share,  of Amylin (the "Common  Stock") or other  securities
(if any) of Amylin as  disclosed  herein,  and,  in the case of Dr. Ende and Mr.
Meckler pursuant to their Consulting Agreements, as described herein, and in the
case of Dr. Thomas F. Deuel and Dr. Peter  Liebert,  pursuant to an agreement in
which certain  affiliates of Carl C. Icahn have agreed to pay each of Dr. Thomas
F. Deuel and Dr.  Peter  Liebert  $25,000 and to  indemnify  each  Nominee  with
respect to certain costs  incurred by each such Nominee in  connection  with the
proxy contest relating to the Annual Meeting (the "Nominee Agreement").

     DR.  ALEXANDER J.  DENNER,  DR.  THOMAS F. DEUEL AND DR. PETER  LIEBERT ARE
COMMITTED  TO ACTING IN THE BEST  INTEREST OF ALL  STOCKHOLDERS  OF AMYLIN.  THE
PARTICIPANTS  URGE YOU TO VOTE YOUR GOLD PROXY CARD FOR DR. ALEXANDER J. DENNER,
DR.  THOMAS F. DEUEL,  AND DR. PETER  LIEBERT AND THE ICAHN  PARTIES URGE YOU TO
VOTE FOR THE NORTH DAKOTA REINCORPORATION PROPOSAL.






                                    IMPORTANT

     According to Amylin's Proxy  Statement,  the Bylaws and applicable law, the
election of the  Nominees  requires the  affirmative  vote of a plurality of the
votes  cast by the  holders  of  Amylin's  Common  Stock at a meeting at which a
quorum  is  present  in  person or  represented  by proxy  and the North  Dakota
Reincorporation  Proposal  requires  the  affirmative  vote of a majority of the
votes  cast by the  holders  of  Amylin's  Common  Stock at a meeting at which a
quorum is present in person or represented by proxy.  As a result,  your vote is
extremely  important.  We urge you to mark,  sign, date, and return the enclosed
GOLD  proxy  card to vote FOR the  election  of each  Nominee  and FOR the North
Dakota Reincorporation Proposal.


     WE URGE YOU NOT TO SIGN ANY PROXY CARD SENT TO YOU BY AMYLIN OR EASTBOURNE.
IF YOU  HAVE  ALREADY  DONE SO,  YOU MAY  REVOKE  YOUR  PROXY  BY  DELIVERING  A
LATER-DATED GOLD PROXY CARD IN THE ENCLOSED POSTAGE-PREPAID ENVELOPE,  EXECUTING
A VOTE VIA INTERNET OR TELEPHONE,  OR BY VOTING IN PERSON AT THE ANNUAL MEETING.
SEE "VOTING PROCEDURES" AND "PROXY PROCEDURES" BELOW.

     If you attend the annual meeting and you  beneficially own shares of Common
Stock but are not the record owner,  your mere  attendance at the Annual Meeting
WILL NOT be  sufficient  to cancel your prior  given  proxy card.  You must have
written  authority  from the record  owner to vote the shares of Common Stock in
its name at the meeting.  Contact D.F.  King & Co.,  Inc. at the number shown in
this proxy statement for assistance or if you have any questions.


     If you have any  questions  or require any  assistance  in  executing  your
proxy, please call:

                              D.F. KING & CO., INC.
                   STOCKHOLDERS CALL TOLL-FREE: (800) 488-8075
                 BANKS AND BROKERS CALL COLLECT: (212) 269-5550


     Only  holders of record of Amylin's  voting  securities  as of the close of
business on April 8, 2009 (the "Record  Date") are entitled to notice of, and to
attend and to vote at, the Annual Meeting and any  adjournments or postponements
thereof.  According to the proxy  statement of Amylin filed with the  Securities
and Exchange  Commission  ("Amylin's Proxy  Statement"),  as of the Record Date,
there were  outstanding  140,874,975  shares of Common  Stock.  Stockholders  of
record at the close of  business on the Record Date will be entitled to one vote
at the  Annual  Meeting  for each  share of Common  Stock of Amylin  held on the
Record Date.

     As of the Record Date, the Participants  and their affiliates  beneficially
owned  an  aggregate  of  12,973,328   shares  of  Common  Stock,   representing
approximately  9.21% of the outstanding shares of Common Stock. The Participants
and their affiliates intend to vote such shares of Common Stock FOR the election
of the Nominees and FOR the North Dakota Reincorporation Proposal.


     VOTE FOR THE NOMINEES AND FOR THE NORTH DAKOTA REINCORPORATION  PROPOSAL BY
USING THE ENCLOSED GOLD PROXY TO VOTE TODAY - BY TELEPHONE,  BY INTERNET,  OR BY
MARKING,  SIGNING,  DATING AND RETURNING THE GOLD PROXY CARD IN THE POSTAGE-PAID
ENVELOPE PROVIDED TO YOU.





PARTICIPANTS IN SOLICITATION OF PROXIES


     In addition to the Nominees (who are Dr. Alexander J. Denner, Dr. Thomas F.
Deuel and Dr. Peter Liebert),  the  participants in the  solicitation of proxies
(the "Participants") from Stockholders of Amylin include the following: Mr. Carl
C. Icahn, Mr. Mayu Sris, Mr. Jeffrey Meckler,  Dr. Eric Ende, Icahn Partners LP,
a Delaware limited partnership  ("Icahn  Partners"),  Icahn Partners Master Fund
LP, a Cayman Islands limited partnership ("Icahn Master"), Icahn Partners Master
Fund II LP, a Cayman Islands  limited  partnership  ("Icahn  Master II"),  Icahn
Partners Master Fund III LP, a Cayman Islands limited partnership ("Icahn Master
III"), Beckton Corp., a Delaware corporation ("Beckton"), Icahn Enterprises G.P.
Inc.,  a  Delaware  corporation  ("Icahn  Enterprises  GP"),  Icahn  Enterprises
Holdings L.P., a Delaware limited partnership  ("Icahn  Enterprises  Holdings"),
IPH GP LLC, a Delaware limited  liability  company ("IPH"),  Icahn Capital LP, a
Delaware limited  partnership  ("Icahn  Capital"),  Icahn Onshore LP, a Delaware
limited  partnership ("Icahn Onshore") and Icahn Offshore LP, a Delaware limited
partnership ("Icahn Offshore").

     The address of Icahn  Partners,  Icahn  Enterprises  GP, Icahn  Enterprises
Holdings, Beckton, IPH, Icahn Capital, Icahn Onshore and Icahn Offshore is White
Plains Plaza,  445 Hamilton  Avenue - Suite 1210,  White Plains,  NY 10601.  The
address of Icahn Master, Icahn Master II and Icahn Master III is c/o Walkers SPV
Limited,  P.O. Box 908GT,  87 Mary Street,  George Town,  Grand  Cayman,  Cayman
Islands.  The business  address of each of Messrs.  Icahn,  Sris and Meckler and
Drs.  Denner and Ende is c/o Icahn  Associates  Corp.,  767 Fifth Avenue,  Suite
4700, New York, NY 10153.  Dr. Deuel's  business address is The Scripps Research
Institute,  MEM 268, 10550 North Torrey Pines Road, La Jolla,  California 92037.
Dr.  Liebert's,  business  address is 222 Westchester  Avenue,  Suite 403, White
Plains, New York 10604.

     Icahn  Partners,  Icahn  Master,  Icahn  Master  II and  Icahn  Master  III
(collectively,  the "Icahn  Parties" or the "Funds") are entities  controlled by
Mr. Icahn.  Dr. Denner and Mr. Sris are employees  and/or officers and directors
of the Icahn Parties and various other entities controlled by Mr. Icahn, who may
also participate in soliciting proxies from Amylin Stockholders. Drs. Denner and
Ende and Messrs.  Sris,  and  Meckler do not own  beneficially  any  interest in
securities  of Amylin.  Dr.  Denner and Mr.  Sris will not  receive  any special
compensation  in connection  with such  solicitation.  In connection  with their
employment by Mr. Icahn and his affiliated  companies,  Dr. Denner,  among other
employees,  has a participatory  interest in the profits and fees derived by Mr.
Icahn and/or his affiliated  entities the Funds.  Because only a portion of such
profit  interests are distributed and because of Dr. Denner's other  investments
in the Funds, Dr. Denner also has capital accounts in the Funds.  Generally,  in
the aggregate,  Dr. Denner's profit  interests and capital accounts in the Funds
entitle him to less than 2% of the profits  generated by the Funds. Dr. Ende and
Mr. Meckler are independent consultants retained by the Icahn Parties to solicit
proxies and provide consulting  services relating to this solicitation,  another
solicitation  of proxies by the Icahn  Parties and general  consulting  services
relating to other investments by the Icahn Parties.  Assuming the Annual Meeting
of Amylin and the annual  meeting  relating to the other  solicitation  are each
held in May and further  assuming  each  contest is  successful  the  agreements
referred to herein may provide for payments of up to approximately $325,000.00


     Each of the  Icahn  Parties  is  principally  engaged  in the  business  of
investing in securities.

     Annex A  attached  hereto  sets  forth,  as to the  Nominees  and the other
Participants,  all transactions in securities of Amylin effected during the past
two years and their beneficial ownership of securities of Amylin.

     With respect to each  Participant  (including the Nominees),  except as set
forth herein or in any of the Annexes attached  hereto,  (i) such Participant is
not,  nor was within  the past year,  a party to any  contract,  arrangement  or
understanding  with  any  person  with  respect  to any  securities  of  Amylin,
including, but not limited to, joint ventures, loan or option arrangements, puts
or calls, guarantees against loss or guarantees of profit, division of losses or
profits,  or the  giving  or  withholding  of  proxies;  and (ii)  neither  such
Participant  nor any of such  Participant's  associates  have any arrangement or
understanding  with any person  with  respect to (A) any  future  employment  by
Amylin or its affiliates or (B) any future  transactions  to which Amylin or any
of its affiliates will or may be a party.


PROPOSAL 1 -- ELECTION OF DIRECTORS


     On  January  30,  2009 the Icahn  Parties  delivered  a letter  to  Amylin,
notifying  Amylin that the Icahn  Parties  intend to  nominate  and will seek to
elect at the Annual Meeting - Dr.  Alexander J. Denner,  Dr. Thomas F. Deuel and
Dr.  Peter  Liebert as  members of the board of  directors  of  Amylin.(1)  Each
Nominee, if elected,  would serve a one-year term and hold office until the 2010
annual meeting of  Stockholders  and until a successor has been duly elected and
qualified. Background information about each of the Nominees is set forth below.


_________________________
(1)  The  notification  letter also  indicated  that we intended to nominate Mr.
     Jules Haimovitz and Dr. Dr. David Sidransky but we have determined, at this
     time, not to nominate them. We reserve the right to change this and, if so,
     we shall file amended proxy materials.






     According  to  Amylin's  Proxy  Statement,  the Board of Amylin  intends to
nominate twelve candidates for election as directors at the Annual Meeting. This
proxy  statement is  soliciting  proxies to elect Dr.  Alexander J. Denner,  Dr.
Thomas F. Deuel and Dr. Peter Liebert,  and to enable  Stockholders  to vote for
the Amylin  nominees other than Joseph C. Cook,  Jr., James R. Gavin III, Jay S.
Skyler, Joseph P. Sullivan and James N. Wilson and the Eastbourne nominees other
than  Marina  S.  Bozilenko,  Charles  M.  Fleischman  and  William  A.  Nuerge.
Therefore,  should a  Stockholder  so  authorize  us, we will cast votes for our
three Nominees, two Eastbourne nominees and seven Amylin nominees.  None of such
Eastbourne  nominees or Amylin  nominees for whom we seek authority to vote have
agreed  to  serve  with  each  other or to serve  with any of our  Nominees,  if
elected.

     The Company has disclosed in its 2009  Preliminary  Proxy Statement that if
as a result of the election of our Nominees  and the nominees of  Eastbourne,  a
majority of the Board ceases to be composed of the incumbent  directors or other
individuals approved by a majority of the incumbent directors, then a "change of
control" under the Company's credit  agreement and a "fundamental  change" under
the indenture for the Company's  convertible  notes due 2014 ("2007 Notes") will
be  triggered.  In  addition,  the  Company  has  stated  that  approval  of the
non-management  nominees  cannot avoid the  occurrence  of a "change of control"
under the credit agreement in the event six or more  non-management are elected.
You should refer to the  Company's  2009  Definitive  Proxy  Statement and other
public filings for more information concerning these provisions.

     On March 24, 2009, San Antonio Fire & Police Pension Fund ("San  Antonio"),
a purported  stockholder  of the Company,  filed a class  action  lawsuit in the
Delaware  Court of Chancery  against the  Company and its  directors  seeking to
disable  debt  acceleration  provisions  that would be triggered in the event of
certain changes in the composition of Amylin's Board in the Company's 2007 Notes
and the 2007  Credit  Agreement.  On April 6, 2009,  San  Antonio  filed a Third
Amended Complaint against the Company,  its directors and Bank of America,  N.A.
(the lead bank on the 2007 Credit Agreement), alleging that the directors of the
Company violated their fiduciary duties by adopting such acceleration provisions
in the 2007 Notes and in the 2007 Credit Agreement and by failing to approve the
nominees of the Icahn Parties and Eastbourne  pursuant to the 2007 Indenture (so
that if the current directors  constitute,  after the 2009 annual meeting,  less
than a majority  of the Board,  a default  in the 2007 Notes  would not  thereby
occur),  that such  acceleration  provisions  in the 2007 Credit  Agreement  are
unlawful  and  invalid,  and  that  the  Company's  disclosures  concerning  the
acceleration provisions are coercive and misleading.  The Icahn Parties moved to
intervene as individual plaintiffs in the lawsuit.

     According to the Form 8K filed by the Company on April 15, 2007, as part of
a  settlement  agreement  between  the Company  and San  Antonio,  the Board has
determined,  subject only to the entry of a final, non-appealable order prior to
May 27, 2009 declaring that the Board possesses the contractual  right to do so,
that the Board will "approve" our Nominees and the  Eastbourne  nominees for the
purpose of the 2007 Notes.

     On April  16,  2009,  San  Antonio  filed a  Fourth  Amended  Class  Action
Complaint For Declaratory  Relief adding Bank of New York Trust Company (Trustee
under the 2007  Indenture)  as a Defendant  and  seeking,  among  other  things,
declarations  that (i) the directors of the Company  breached their duty of care
in  approving  the  acceleration  provisions  in the 2007  Notes and in the 2007
Credit  Agreement  (ii) the Board  possesses  the sole right and power under the
terms of the 2007  Indenture  to approve any  nominations  proposed by the Icahn
Parties or  Eastbourne  in order to  nullify  "continuing  director"  repurchase
obligations in the 2007 Notes, or in the alternative,  that those provisions are
invalid and (ii) the change of control  repurchase  provision in the 2007 Credit
Agreement is invalid and unenforceable.

     Trial remains scheduled for May 4 and 5, 2009.

     As of the date of this  filing,  it is not clear  what the full  Eastbourne
slate of nominees will be.  Therefore,  it is possible the results of the voting
by  Stockholders  could be that at least six persons who are elected will not be
current directors, and that the court in the Delaware action will not have ruled
such that  either  the terms of the 2007 Notes or of the 2007  Credit  Agreement
will cause there to be an acceleration of the debt instruments  covered thereby.
On the  other  hand if the  Eastbourne  slate  consists  of the  two  Eastbourne
nominees for whom we seek the authority to vote and if it seeks the authority to
vote for our  nominees,  then it will not be  possible  for there to be  elected
enough persons who are not currently directors (assuming the Company nominates a
slate of twelve  directors) so that the applicable terms of the debt instruments
will not be violated and the debt will not thereby be accelerated.

     Dr. Alexander J. Denner, Dr. Thomas F. Deuel and Dr. Peter Liebert are each
party to a Nominee Agreement, substantially in the form attached hereto as Annex
B,  pursuant to which the Icahn  Parties have agreed to pay certain fees to each
such Nominee  (other than Dr.  Denner) and to  indemnify  each such Nominee with
respect to certain costs  incurred by each such Nominee in  connection  with the
proxy contest relating to the Annual Meeting.  Except as disclosed in this Proxy
Statement,  including the Annexes attached hereto and as provided in the Nominee
Agreement  (which,  among other  things,  provides  for a payment to each of Dr.
Thomas F. Deuel and Dr.  Peter  Liebert of $25,000),  none of the Nominees  will
receive any compensation from any of the Participants or any of their affiliates
in connection  with this proxy  solicitation.  Dr. Thomas F. Deuel and Dr. Peter
Liebert  have an interest in the  election of  directors  at the Annual  Meeting
pursuant to the Nominee Agreement  relating to such Nominee.  Dr. Liebert has an
interest in the election  through his ownership of 2,000 shares of Common Stock.
Dr.  Denner has an interest in the election of  directors at the Annual  Meeting
indirectly through his capital accounts and other investments in the Funds.


     The Nominees would not be barred from being  considered  independent  under
the  independence  requirements  of  The  NASDAQ  Stock  Market,  Inc.  and  the
independence  standards  applicable to Amylin under paragraph (a)(1) of Item 407
of Regulation S-K under the Securities Exchange Act of 1934, as amended.

     Other than as  disclosed  in this Proxy  Statement,  including  the Annexes
attached hereto, (i) the Nominees are not, nor were they within the past year, a
party to any contract, arrangement or understanding with any person with respect
to any securities of Amylin, including, but not limited to, joint ventures, loan
or option arrangements,  puts or calls, guarantees against loss or guarantees of
profit,  division of losses or profits, or the giving or withholding of proxies;
and (ii) none of the Nominees nor any of their  respective  associates  have any
arrangement  or  understanding  with any person  with  respect to (A) any future
employment by Amylin or its affiliates or (B) any future  transactions  to which
Amylin or any of its affiliates will or may be a party.

DR. ALEXANDER J. DENNER

     Dr.  Alexander  J.  Denner,  39,serves  as  Managing  Director  of entities
affiliated with Carl C. Icahn,  including Icahn  Partners,  Icahn Master,  Icahn
Master II and Icahn Master III. Icahn  Partners,  Icahn Master,  Icahn Master II
and Icahn Master III are private investment funds. Dr. Denner has served in this
position since August 2006.  From April 2005 to May 2006, Dr. Denner served as a
portfolio  manager  specializing  in  healthcare  investments  for Viking Global
Investors.  Previously,  he  served in a  variety  of roles at  Morgan  Stanley,
beginning  in  1996,   including  as  portfolio   manager  of   healthcare   and
biotechnology  mutual  funds.  Dr.  Denner  was the  chairman  of the  Executive
Committee of the Board of Directors of ImClone Systems Incorporated,  a publicly
traded biopharmaceutical company, and a director of ImClone Systems Incorporated
from April 2006 until the company was  purchased in November  2008. In addition,
Dr. Denner has served as a director of Adventrx Pharmaceuticals Inc., a publicly
traded  biopharmaceutical  company since October 2006.  Dr. Denner  received his
S.B.  degree  from the  Massachusetts  Institute  of  Technology  and his  M.S.,
M.Phil., and Ph.D. degrees from Yale University.

DR. THOMAS F. DEUEL

     Dr.  Deuel,  74, is  currently a Professor of  Molecular  and  Experimental
Medicine  and Cell  Biology,  Director of the  Division of  Molecular  Oncology,
Department of Molecular and Experimental  Medicine, and Director of the Vascular
Biology  Affinity Group at The Scripps  Research  Institute since February 2002.
Also,  since 1998,  Dr.  Deuel has served as a Professor  of Medicine at Harvard
Medical School. He is currently a Professor  Emeritus at Harvard Medical School.
In addition,  from 1996 to 2002,  Dr.  Deuel  served as a Director,  Division of
Growth Regulation at Beth Israel Hospital,  Boston,  Massachusetts and, prior to
that,  was a Professor  of Medicine  and  Biochemistry  and the head of Oncology
Services at the Washington University School of Medicine,  St. Louis,  Missouri.
He is a member of the Institute of Medicine at the National Academy of Sciences.
Dr. Deuel is also President of the Edward R. Mallinckrodt Foundation, St. Louis,
Missouri.  He has served on various editorial  boards,  including the Journal of
Clinical  Investigation  and Blood,  and currently is on the Editorial  Board of
Current Opinion in Hematology and Section Editor for Vascular Biology. Dr. Deuel
has served and  continues to serve on numerous  scientific  advisory  boards for
various  companies,  including  scientific  advisory  board of  ImClone  Systems
Incorporated,  a publicly traded biopharmaceutical company, during the existence
of such board (from 1988 to 2001).  From July 2007 to November  2008,  Dr. Deuel
had  served on  ImClone's  board of  directors.  Dr.  Deuel  holds an M.D.  from
Columbia University and an A.B. from Princeton University.



DR. PETER LIEBERT

     Dr.  Liebert,  73,  served  as  a  director  of  ImClone  Systems  Inc.,  a
biotechnology  company,  between October 2006 and November 2008. Dr. Liebert has
been a pediatric surgeon in private practice since 1968 and is Chief,  Pediatric
Surgery, The Stamford Hospital, Stamford, CT. From 1981 to 2006, Dr. Liebert was
Clinical Associate  Professor of Surgery at the College of Physicians & Surgeons
of Columbia  University.  Dr. Liebert is currently  President of the Westchester
Surgical  Society.  Dr. Liebert is a former president of the Westchester  County
Medical Society and a former member of the Awards Jury of the Lasker Foundation.
Dr. Liebert is a member of the editorial  board of the Journal of Medicinal Food
focusing on prevention of adolescent  and young adult obesity and diabetes.  Dr.
Liebert is  Chairman of the Board of Rx  Vitamins,  Inc.  and is a director  of
Cadus Corporation, a publicly held, drug discovery company controlled by Carl C.
Icahn.  Dr.  Liebert holds an M.D. from Harvard  Medical School and an A.B. from
Princeton  University.




     WE STRONGLY  URGE YOU TO VOTE FOR THE ELECTION OF DR.  ALEXANDER J. DENNER,
DR.  THOMAS F. DEUEL AND DR.  PETER  LIEBERT  BY  MARKING,  SIGNING,  DATING AND
RETURNING THE ENCLOSED GOLD PROXY CARD IN THE POSTAGE PAID ENVELOPE  PROVIDED TO
YOU WITH  THIS  PROXY  STATEMENT  OR BY USING  THE  GOLD  PROXY  CARD TO VOTE BY
TELEPHONE OR INTERNET.  IF YOU HAVE SIGNED THE GOLD PROXY CARD AND NO MARKING IS
MADE,  YOU WILL BE DEEMED TO HAVE  GIVEN A  DIRECTION  TO VOTE ALL THE SHARES OF
COMMON  STOCK  REPRESENTED  BY THE  GOLD  PROXY  CARD  FOR THE  ELECTION  OF DR.
ALEXANDER  J.  DENNER,  DR.  THOMAS  F.  DEUEL  AND DR.  PETER  LIEBERT  AND THE
EASTBOURNE  NOMINEES OTHER THAN MARINA S.  BOZILENKO,  CHARLES M. FLEISCHMAN AND
WILLIAM A. NUERGE AND THE AMYLIN  NOMINEES OTHER THAN JOSEPH C. COOK, JR., JAMES
R. GAVIN III, JAY S. SKYLER, JOSEPH P. SULLIVAN AND JAMES N. WILSON.


PROPOSAL 5 -- NORTH DAKOTA REINCORPORATION PROPOSAL


The proposal states:

          "RESOLVED, that the stockholders of the Corporation hereby request the
     Board of  Directors of the  Corporation  to take all action as is necessary
     and appropriate to properly initiate and complete the process to change the
     Corporation's  jurisdiction of incorporation  from Delaware to North Dakota
     and to become  subject to the North  Dakota  Publicly  Traded  Corporations
     Act."


     The Icahn Parties believe that North Dakota  Publicly  Traded  Corporations
Act is the most stockholder-friendly  corporation law in the United States as it
relates to public companies and that being incorporated there and subject to the
North Dakota Act would give Stockholders  considerably  more protection  against
management   entrenchment  and  would  make  it  easier  for  third  parties  to
successfully  bid for the Company.  Although  there can be no  assurances,  this
could enable  Stockholders,  in some cases, to achieve a premium over market for
their shares of Common Stock.


     Other   than  the  change  in   corporate   domicile,   the  North   Dakota
Reincorporation  is not  intended  to  result  in any  change  in the  business,
physical location,  management, assets, liabilities or net worth of the Company,
nor is it intended  to result in any change in  location  of Company  employees,
including  the  Company's  management.  Upon  consummation  of  a  North  Dakota
Reincorporation,  it is anticipated  that the daily  business  operations of the
Company will continue as they are presently conducted.

Principal Reasons for the Reincorporation


     The  Icahn   Parties   believe  that  there  are  several   reasons  why  a
reincorporation  to North  Dakota  and  becoming  subject  to the  North  Dakota
Publicly  Traded  Corporations  Act is in the best  interests  of Amylin and its
Stockholders.  If the Company were governed by the North Dakota  Publicly Traded
Corporations Act as opposed to the General Corporation Law of Delaware:


o    The board of directors would be elected by a majority vote (as opposed to a
     mere  plurality) and directors  defeated  under the majority  voting system
     would be prohibited  from being appointed by the board of directors to fill
     a vacancy;

o    The board of directors could not be classified  (staggered),  each director
     would be elected every year and the board of directors would not be able to
     change  its size when it has reason to  believe  there will be a  contested
     election;

o    The  chairman  of the board of  directors  could not serve as an  executive
     officer;

o    Shareholders  who have  held  five  percent  (5%) or more of the  Company's
     outstanding shares for at least two years would have access to management's
     proxy statement to nominate directors;

o    All  shareholders  would be reimbursed  for proxy  contest  expenses in the
     election of directors, to the extent they are successful;

o    Shareholders would be statutorily entitled to an advisory vote each year on
     executive compensation (a "say on pay" proposal);

o    The ability of the board of  directors  to adopt and maintain a poison pill
     would be limited in several respects;

o    Antitakeover  provisions proposed for inclusion in the Company's charter or
     bylaws  would  require  the prior  approval  of  two-thirds  of the  shares
     entitled to vote;

o    Shareholders  could not be required  to provide  more than ninety (90) days
     notice in advance of a shareholder  meeting when making  nominations to the
     board  of  directors  and  there  would  be  limitations  on  the  type  of
     information that could be required in connection with such nominations;

o    Shareholders who own 5% or more of the Company's  outstanding  shares would
     have a right to propose and approve  amendments  to the  Company's  charter
     without prior board approval; and

o    The  Company  could not add a  requirement  to its  charter or bylaws  that
     certain actions require the approval of a super majority vote.


     The  North  Dakota   Publicly   Traded   Corporations   Act  would  provide
shareholders  more rights than are  generally  currently  available  under other
state  corporation  laws,  including  Delaware,  where the Company is  currently
incorporated,   as  further   described  above  under  "Principal   Reasons  for
Reincorporation."  Moreover,  the North Dakota Publicly Traded  Corporations Act
expressly  provides that it "must be liberally  construed to protect and enhance
the rights of shareholders in publicly traded corporations."


     In addition to providing  increased  shareholder  rights,  the North Dakota
Publicly  Traded  Corporations  Act  contains a  franchise  tax  system  that is
specifically  designed to impose  significantly  less cost on companies than the
Delaware   franchise  tax  system,   thereby   providing   additional  value  to
shareholders.


THE ICAHN PARTIES STRONGLY URGE YOU TO VOTE FOR THE NORTH DAKOTA  REINCORPOATION
PROPOSAL BY MARKING,  SIGNING, DATING AND RETURNING THE ENCLOSED GOLD PROXY CARD
IN THE POSTAGE  PAID  ENVELOPE  PROVIDED TO YOU WITH THIS PROXY  STATEMENT OR BY
USING THE GOLD PROXY CARD TO VOTE BY TELEPHONE  OR INTERNET.  IF YOU HAVE SIGNED
THE GOLD PROXY  CARD AND NO MARKING IS MADE,  YOU WILL BE DEEMED TO HAVE GIVEN A
DIRECTION TO VOTE ALL THE SHARES OF COMMON STOCK  REPRESENTED  BY THE GOLD PROXY
CARD FOR THE NORTH DAKOTA REINCORPORATION PROPOSAL.


OTHER MATTERS TO BE CONSIDERED AT THE ANNUAL MEETING


     According to Amylin's Proxy  Statement,  Amylin is soliciting  proxies with
respect to three other proposals. Please refer to Amylin's Proxy Statement for a
detailed discussion of these proposals,  including various arguments in favor of
and against such  proposals.  These  proposals are outlined  below.  IF YOU HAVE
SIGNED THE GOLD  PROXY  CARD AND NO MARKING IS MADE,  YOU WILL BE DEEMED TO HAVE
GIVEN A DIRECTION TO VOTE ALL OF THE SHARES OF COMMON STOCK  REPRESENTED BY YOUR
GOLD PROXY CARD (I) FOR PROPOSALS 2, 3 and 4 LISTED BELOW.


PROPOSAL 2 -- APPROVAL OF AMYLIN'S 2009 EQUITY INCENTIVE PLAN

According to the Company's 2009  Definitive  Proxy  Statement,  the Company will
also solicit proxies with respect to a proposal for the  Stockholders to approve
the Company's 2009 Equity Incentive Plan ("EIP").  Please refer to the Company's
2009  Definitive  Proxy  Statement  for  a  discussion  of  such  proposal.  The
Participants intend to vote, and recommend that you vote, FOR this proposal.


PROPOSAL 3 -- APPROVAL OF AMENDMENT OF THE 2001 EMPLOYEE STOCK PURCHASE PLAN

According to the Company's 2009  Definitive  Proxy  Statement,  the Company will
also solicit proxies with respect to a proposal for the  Stockholders to approve
an  increase  of  1,500,000  shares  in the  aggregate  number  of shares of the
Company's Common Stock authorized for issuance under the Company's 2001 Employee
Stock Purchase Plan (the "2001 Employee Stock Purchase Plan  Proposal").  Please
refer to the Company's 2009 Definitive  Proxy Statement for a discussion of such
proposal. The Participants intend to vote, and recommend that you vote, FOR this
proposal.

PROPOSAL  4 --  RATIFICATION  OF  SELECTION  OF  INDEPENDENT  REGISTERED  PUBLIC
                ACCOUNTING FIRM

According to the Company's 2009 Definitive  Proxy  Statement,  the  Stockholders
will be asked to vote to ratify the  selection  of Ernst & Young LLP as Amylin's
independent  registered  public  accounting  firm  for the  fiscal  year  ending
December 31, 2009. The Participants intend to vote, and recommend that you vote,
FOR this proposal.


OTHER PROPOSALS

     The  Participants  and their  affiliates  know of no other  business  to be
presented at the Annual  Meeting.  If any other  matters  should  properly  come
before the Annual Meeting, it is intended that the persons named on the enclosed
GOLD proxy card will vote that proxy on such other  matters in  accordance  with
their judgment.

VOTING PROCEDURES

     According  to Amylin's  Proxy  Statement,  the Bylaws and  applicable  law,
holders of shares of  Amylin's  Common  Stock,  at the close of  business on the
Record Date are entitled to notice of, and to vote at, the Annual Meeting.  Each
share of Common Stock  outstanding on the Record Date is entitled to one vote on
each matter presented at the Annual Meeting.


     According  to Amylin's  Proxy  Statement,  the Bylaws and  applicable  law,
directors  are  elected  by a  plurality  of the votes  cast by the  holders  of
Amylin's Common Stock at a meeting at which a quorum is present. Plurality means
that the individuals who receive the largest number of votes cast are elected as
directors,  up to the maximum  number of  directors to be chosen at the meeting.
Consequently,  any  shares of Common  Stock not voted  (whether  by  abstention,
broker  non-vote or otherwise)  have no impact in the election of  directors.  A
quorum is the  presence  by person or by proxy of a  majority  of the  shares of
Common Stock issued and  outstanding and entitled to vote at the Annual Meeting.
The shares of Common Stock represented by a proxy marked "withhold" or "abstain"
will be considered  present at the Annual  Meeting for purposes of determining a
quorum.


BROKER NON-VOTES


     If you hold your  shares of Common  Stock  through a bank,  broker or other
nominee  and do not  provide  voting  instructions  to the record  holder of the
shares of Common  Stock,  your  shares of Common  Stock will not be voted on any
proposal on which your broker or nominee does not have  discretionary  authority
to vote.  In this  case,  a "broker  non-vote"  occurs.  Shares of Common  Stock
constituting  broker  non-votes  are not  counted  or  deemed to be  present  or
represented for the purpose of determining whether  shareholders have approved a
matter,  but they are counted as present for the purpose of determining a quorum
at the Annual Meeting.

     For the Annual Meeting, because of the solicitation of proxies described in
this proxy  statement,  the  election of  directors  at the Annual  Meeting is a
"non-routine  matter" and brokers do not have  discretionary  authority  to vote
your shares of Common  Stock on  "non-routine  matters."  Therefore,  unless you
provide specific voting  instructions to your broker,  your broker will not have
discretionary  authority to vote your shares of Common Stock for the election of
directors  at the Annual  Meeting  and your  shares of Common  Stock will not be
voted for any of the nominees. If your shares of Common Stock are held in street
name,  your broker or nominee has enclosed a voting  instruction  card with this
proxy statement.  We strongly  encourage you to vote your shares of Common Stock
by following the instructions provided on the voting instruction card

     According to Amylin's Proxy  Statement,  the Bylaws and applicable law, the
affirmative  vote of a majority of shares of Common  Stock  present in person or
represented  by proxy at the Annual  Meeting and  entitled  to vote  thereon are
required to (i) approve the North Dakota Reincorporation Proposal, (ii) approval
of Amylin's 2009 Equity  Incentive Plan;  (iii) approval of the amendment to the
2001  Employee  Stock  Purchase  Plan;  and (iv)  ratify  the  selection  of the
independent registered accounting firm.


     As explained in the detailed  instructions  on your GOLD proxy card,  there
are four ways you may vote. You may:

     1.   Sign,  date and return the  enclosed  GOLD proxy card in the  enclosed
          postage-paid  envelope.  We recommend  that you vote on the GOLD proxy
          card even if you plan to attend the Annual Meeting;

     2.   Vote via the Internet by following the voting instructions on the GOLD
          proxy card or the voting instructions provided by your broker, bank or
          other holder of record.

     3.   Vote by  telephone by following  the voting  instructions  on the GOLD
          proxy card or the instructions  provided by your broker, bank or other
          holder of record; or


     4.   Vote in person by attending the Annual  Meeting.  Written ballots will
          be  distributed  to  Stockholders  who wish to vote in  person  at the
          Annual  Meeting.  If you hold your  shares of Common  Stock  through a
          bank,  broker or other  custodian,  you must obtain a legal proxy from
          such custodian in order to vote in person at the meeting.


     To submit a proxy with voting  instructions  by  telephone  please call the
telephone  number  listed on the GOLD proxy card.  Proxies may also be submitted
over  the  Internet.  Please  refer  to the  GOLD  proxy  card  for the  website
information.  In each case  Stockholders  will be required to provide the unique
control number which has been printed on each  Stockholder's GOLD proxy card. In
addition to the  instructions  that appear on the GOLD proxy card,  step-by-step
instructions  will  be  provided  by a  recorded  telephone  message  for  those
Stockholders  submitting proxies by telephone,  or at the designated website for
those Stockholders submitting proxies over the Internet. Stockholders submitting
their  proxies with voting  instructions  by telephone or over the Internet will
receive  confirmation  on  the  telephone  that  their  vote  by  telephone  was
successfully  submitted,  and may provide an email address for confirmation that
their vote by Internet was successfully submitted.


     Whether or not you are able to attend the Annual Meeting,  you are urged to
complete the enclosed  GOLD proxy and return it in the enclosed  self-addressed,
prepaid envelope. All valid proxies received prior to the meeting will be voted.
If you specify a choice with respect to any item by marking the  appropriate box
on the proxy,  the shares of Common Stock will be voted in accordance  with that
specification.  IF NO  SPECIFICATION IS MADE, THE SHARES OF COMMON STOCK WILL BE
VOTED (I) FOR DR. ALEXANDER J. DENNER FOR DIRECTOR; (II) FOR DR. THOMAS F. DEUEL
FOR DIRECTOR; (III) FOR DR. PETER LIEBERT FOR DIRECTOR; (IV) FOR THE PERSONS WHO
HAVE BEEN  NOMINATED BY EASTBOURNE  TO SERVE AS DIRECTORS,  OTHER THAN MARINA S.
BOZILENKO,  CHARLES M. FLEISCHMAN AND WILLIAM A. NUERGE; (V) FOR THE PERSONS WHO
HAVE BEEN NOMINATED BY AMYLIN TO SERVE AS DIRECTORS,  OTHER THAN JOSEPH C. COOK,
JR., JAMES R. GAVIN III, JAY S. SKYLER,  JOSEPH P. SULLIVAN AND JAMES N. WILSON;
(VI) FOR THE NORTH  DAKOTA  REINCORPOATION  PROPOSAL;  (VII) FOR  AMYLIN'S  2009
EQUITY  INCENTIVE  PLAN;  (VIII) FOR THE  AMENDMENT TO THE 2001  EMPLOYEE  STOCK
PURCHASE PLAN;  (IX) FOR THE  RATIFICATION  OF THE SELECTION OF THE  INDEPENDENT
REGISTERED ACCOUNTING FIRM; AND (X) IN THE PROXY HOLDERS' DISCRETION AS TO OTHER
MATTERS THAT MAY PROPERLY COME BEFORE THE ANNUAL MEETING.


     If you have any  questions  or require any  assistance  in  executing  your
proxy, please call:

                              D.F. KING & CO., INC.
                   STOCKHOLDERS CALL TOLL-FREE: (800) 488-8075
                 BANKS AND BROKERAGE FIRMS CALL: (212) 269-5550

PROXY PROCEDURES

     IN ORDER FOR YOUR VIEWS TO BE  REPRESENTED  AT THE ANNUAL  MEETING,  PLEASE
MARK,  SIGN,  DATE AND RETURN  THE  ENCLOSED  GOLD  PROXY  CARD IN THE  ENCLOSED
POSTAGE-PREPAID  ENVELOPE  OR USE THE GOLD  PROXY CARD TO VOTE BY  TELEPHONE  OR
INTERNET.

     The  accompanying  GOLD proxy  card will be voted at the Annual  Meeting in
accordance with your instructions on such card.


     Only  holders of record as of the close of business on the Record Date will
be entitled to vote. If you were a Stockholder of record on the Record Date, you
will  retain  your  voting  rights at the Annual  Meeting  even if you sell such
shares of Common Stock after the Record Date. Accordingly,  it is important that
you vote the shares of Common Stock held by you on the Record  Date,  or grant a
proxy to vote such shares of Common  Stock on the GOLD proxy  card,  even if you
sell such shares of Common Stock after the Record Date.

     IF YOUR SHARES OF COMMON  STOCK ARE HELD IN THE NAME OF A  BROKERAGE  FIRM,
BANK,  BANK NOMINEE OR OTHER  INSTITUTION  ON THE RECORD DATE,  ONLY IT CAN VOTE
SUCH SHARES OF COMMON STOCK AND ONLY UPON RECEIPT OF YOUR SPECIFIC INSTRUCTIONS.
ACCORDINGLY, PLEASE CONTACT THE PERSON RESPONSIBLE FOR YOUR ACCOUNT AND INSTRUCT
THAT PERSON TO EXECUTE ON YOUR BEHALF THE GOLD PROXY CARD AS SOON AS POSSIBLE.



REVOCATION OF PROXIES


     Any   Stockholder  of  record  may  revoke  or  change  his  or  her  proxy
instructions at any time prior to the vote at the Annual Meeting by:

     o    submitting  a properly  executed,  subsequently  dated GOLD proxy card
          that will revoke all prior proxy  cards,  including  any Blue or White
          proxy cards which you may have submitted to Amylin;

     o    instructing  the Icahn  Parties by telephone or via the Internet as to
          how you would like your shares of Common Stock voted (instructions are
          on your GOLD proxy card);


     o    attending  the  Annual  Meeting  and  withdrawing  his or her proxy by
          voting in person  (although  attendance at the Annual Meeting will not
          in and of itself constitute revocation of a proxy); or

     o    delivering  written  notice of revocation  either to the Icahn Parties
          c/o D.F. King & Co., Inc., 48 Wall Street,  New York, NY 10005, or the
          Corporate Secretary of Amylin.

     Although a  revocation  is  effective  if  delivered  to Amylin,  the Icahn
Parties  request that either the original or a copy of any  revocation be mailed
to the Icahn  Parties c/o D.F. King & Co.,  Inc.,  48 Wall Street,  New York, NY
10005, so that the Icahn Parties will be aware of all revocations.


     IF YOU PREVIOUSLY SIGNED AND RETURNED A WHITE OR BLUE PROXY CARD TO AMYLIN,
WE URGE YOU TO REVOKE IT BY (1) MARKING,  SIGNING, DATING AND RETURNING THE GOLD
PROXY CARD,  (2)  INSTRUCTING  US BY TELEPHONE OR VIA THE INTERNET AS TO HOW YOU
WOULD LIKE YOUR  SHARES OF COMMON  STOCK  VOTED  WITH  RESPECT TO THE GOLD PROXY
CARD,  (3) ATTENDING THE ANNUAL MEETING AND VOTING IN PERSON OR (4) DELIVERING A
WRITTEN NOTICE OF REVOCATION TO THE ICAHN PARTIES OR TO THE CORPORATE  SECRETARY
OF THE COMPANY.



COST AND METHOD OF SOLICITATION


     Solicitation  of proxies shall be made by Drs.  Denner and Ende and Messrs.
Icahn, Sris and Meckler.


     The Icahn Parties have retained  D.F.  King & Co.,  Inc.  ("D.F.  King") to
conduct the solicitation,  for which D.F. King is to receive a fee not to exceed
$150,000,  plus  reimbursement for its reasonable  out-of-pocket  expenses.  The
Icahn Parties have agreed to indemnify D.F. King against certain liabilities and
expenses,  including  certain  liabilities  under the federal  securities  laws.
Insofar as indemnification  for liabilities arising under the federal securities
laws may be permitted to D.F. King pursuant to the foregoing provisions, we have
been informed  that in the opinion of the  Securities  and Exchange  Commission,
such  indemnification  is against public policy and is therefore  unenforceable.
Proxies may be  solicited  by mail,  courier  services,  Internet,  advertising,
telephone or  telecopier  or in person.  It is  anticipated  that D.F. King will
employ up to [75] persons to solicit  proxies from Amylin  Stockholders  for the
Annual Meeting. The total expenditures in furtherance of, or in connection with,
the solicitation of proxies is approximately [$] to date, and is estimated to be
[$] in total.

     The Icahn  Parties  do not intend to seek  reimbursement  for the costs and
expenses  associated  with the proxy  solicitation  in the event that any of the
Nominees are elected to the Board of Directors of Amylin.


CERTAIN LITIGATION


     The  Company  has issued  $575  million of notes  (the "2007  Notes"),  the
indenture for which (the "Indenture") provides the holders of the 2007 Notes the
right to require  the Company to  repurchase  the 2007 Notes at a price equal to
100% of the principal amount thereof,  together with accrued and unpaid interest
thereon,  within 35 days after the date upon which "continuing directors" do not
constitute a majority of the Company's Board.  Under the Indenture,  "continuing
directors" are  individuals  who constituted the Board of Directors on the issue
date of the 2007  Notes,  or any new  directors  whose  election to the Board or
nomination  for election  was  approved by at least a majority of the  directors
still in office.

     The Company is also party to a Credit Agreement with certain banks dated as
of December 21, 2007  pursuant to which the Company has borrowed  $125  million.
Under the 2007 Credit Agreement,  borrowed funds become repayable upon a "change
of  control,"  which is defined to occur when  persons  who were  members of the
Board at the start of any 24 month period no longer constitute a majority of the
Board,  unless the  nomination  of the new  directors  was approved by the prior
members  of the  board,  other  than as a  result  of an  actual  or  threatened
solicitation of proxies or consents for the election or removal of directors.

     On March 24, 2009, San Antonio Fire & Police Pension Fund ("San  Antonio"),
a purported  stockholder  of the Company,  filed a class  action  lawsuit in the
Delaware  Court of Chancery  against the  Company and its  directors  seeking to
disable  debt  acceleration  provisions  that would be triggered in the event of
certain  changes in the composition of the Company's Board in the Company's 2007
Notes and the 2007 Credit Agreement. On April 6, 2009, San Antonio filed a Third
Amended Complaint against the Company,  its directors and Bank of America,  N.A.
(the lead bank on the Credit  Agreement),  alleging  that the  directors  of the
Company violated their fiduciary duties by adopting the acceleration  provisions
in the 2007 Notes and in the 2007 Credit Agreement and by failing to approve the
nominees of the Icahn  Parties and  Eastbourne  pursuant to the 2007  Indenture,
that the  acceleration  provisions in the 2007 Credit Agreement are unlawful and
invalid,  and  that  the  Company's  disclosures   concerning  the  acceleration
provisions are coercive and misleading.  The Icahn Parties moved to intervene as
individual plaintiffs in the lawsuit. The court ordered expedited proceedings in
the lawsuit,  and scheduled a trial for May 4 and 5, 2009.

     According  to the Form 8-K  filed by the  Company  on April 15,  2007,  the
Company and San Antonio  agreed to a partial  settlement of the action by which,
among other things, the Board determined,  subject only to the entry of a final,
non-appealable  order prior to May 27, 2009 declaring  that the Board  possesses
the  contractual  right to do so, that the Board will "approve" our Nominees and
the Eastbourne nominees for the purpose of the 2007 Notes.

     On April  16,  2009,  San  Antonio  filed a  Fourth  Amended  Class  Action
Complaint For Declaratory  Relief adding Bank of New York Trust Company (Trustee
under the 2007  Indenture)  as a Defendant  and  seeking,  among  other  things,
declarations  that (i) the directors of the Company  breached their duty of care
in  approving  the  acceleration  provisions  in the 2007  Notes and in the 2007
Credit  Agreement  (ii) the Board  possesses  the sole right and power under the
terms of the 2007  Indenture  to approve any  nominations  proposed by the Icahn
Parties or  Eastbourne  in order to  nullify  "continuing  director"  repurchase
obligations in the 2007 Notes, or in the alternative,  that those provisions are
invalid and (ii) the change of control  repurchase  provision in the 2007 Credit
Agreement is invalid and unenforceable.

     Trial remains scheduled for May 4 and 5, 2009.


ADDITIONAL INFORMATION

     Certain  information  regarding  the  securities of Amylin held by Amylin's
directors,  management  and 5%  Stockholders  is  contained  in  Amylin's  Proxy
Statement.  Information  concerning  the date by  which  proposals  of  security
holders  intended to be presented at the next annual meeting of  Stockholders of
Amylin must be received by Amylin for inclusion in Amylin's Proxy  Statement and
form of proxy for that meeting is also  contained in Amylin's  Proxy  Statement.
This  information is expected to be contained in Amylin's  public  filings.  The
Participants  take no  responsibility  for the accuracy or  completeness of such
information contained in Amylin's public filings.


Date:


                                             CARL C. ICAHN
                                             DR. ALEXANDER J. DENNER
                                             DR. THOMAS F. DEUEL
                                             DR. PETER LIEBERT
                                             ICAHN PARTNERS LP
                                             ICAHN PARTNERS MASTER FUND LP
                                             ICAHN PARTNERS MASTER FUND II LP
                                             ICAHN PARTNERS MASTER FUND III LP
                                             ICAHN ENTERPRISES G.P. INC.
                                             ICAHN ENTERPRISES HOLDINGS L.P.
                                             IPH GP LLC
                                             ICAHN CAPITAL L.P.
                                             ICAHN ONSHORE LP
                                             ICAHN OFFSHORE LP
                                             BECKTON CORP.






ANNEX A

BENEFICIAL OWNERSHIP OF SECURITIES OF AMYLIN


Beneficial  Ownership  by the Icahn  Parties of  Securities  of Amylin as of the
close of business on April 22, 2009:


(1) Title          (2) Name of Beneficial    (3) Amount and    (4) Percent of
    of                 Beneficial                Nature of         Class (3)
    Class              Owner (2)                 Beneficial
                                                 Ownership


Common Stock,          Icahn Partners             4,533,433          3.22%
par value $0.001
per share
Common Stock,          Icahn Master               5,592,721          3.97%
par value $0.001
per share
Common Stock,          Icahn Master II            2,057,967          1.46%
par value $0.001
per share
Common Stock,          Icahn Master III             787,207          0.56%
par value $0.001
per share



_________________________
(2)  Please note that each record holder listed in this table is, as of the date
     of this filling,  the direct beneficial owner of the shares set forth under
     the  heading  "(3)  Amount  of  Beneficial  Ownership"  and  that  indirect
     beneficial ownership of shares is described below in the text of this Annex
     A under the heading "Description of Beneficial Ownership."

(3)  Please note that  percentages  of  ownership  set forth in this column were
     calculated  based on the  amount of shares  of  Common  Stock  stated to be
     outstanding  as April 8, 2009 by the  Company in the  Company's  Definitive
     Proxy Statement.






INFORMATION ABOUT MR. ICAHN

     Mr.  Icahn has an  interest  in the  election  of  directors  at the Annual
Meeting indirectly through the beneficial ownership of securities,  as described
below.

Carl C. Icahn has served as  chairman  of the board and a director  of  Starfire
Holding Corporation ("Starfire"), a privately-held holding company, and chairman
of the board and a director of various  subsidiaries  of  Starfire,  since 1984.
Since August  2007,  through his  position as Chief  Executive  Officer of Icahn
Capital  LP,  a  wholly-owned  subsidiary  of  Icahn  Enterprises  L.P.  ("Icahn
Enterprises"), and certain related entities, Mr. Icahn's principal occupation is
managing private  investment funds,  including Icahn Partners LP, Icahn Partners
Master Fund LP, Icahn Partners Master Fund II LP, and Icahn Partners Master Fund
III LP. Prior to August 2007, Mr. Icahn  conducted this  occupation  through his
entities CCI Onshore Corp. and CCI Offshore  Corp.,  since November 2004.  Since
November  1990,  Mr. Icahn has been  chairman of the board of Icahn  Enterprises
G.P.  Inc., the general  partner of Icahn  Enterprises.  Icahn  Enterprises is a
diversified  holding  company  engaged  in a variety  of  businesses,  including
investment  management,  metals,  real estate,  and home fashion.  Mr. Icahn was
chairman  of the  board  and  president  of  Icahn  & Co.,  Inc.,  a  registered
broker-dealer  and a member of the National  Association of Securities  Dealers,
from 1968 to 2005.  Mr.  Icahn  has  served  as  chairman  of the board and as a
director of American  Railcar  Industries,  Inc.,  a company  that is  primarily
engaged in the business of manufacturing covered hopper and tank railcars, since
1994.  From  October 1998 through May 2004,  Mr. Icahn was the  president  and a
director of Stratosphere Corporation, the owner and operator of the Stratosphere
Hotel and Casino in Las Vegas,  which,  until February 2008, was a subsidiary of
Icahn Enterprises. From September 2000 to February 2007, Mr. Icahn served as the
chairman of the board of GB Holdings,  Inc., which owned an interest in Atlantic
Coast  Holdings,  Inc.,  the owner and  operator of The Sands casino in Atlantic
City until November 2006.  From September 2006 to November 2008, Mr. Icahn was a
director  of  ImClone  Systems  Incorporated  ("ImClone"),  a  biopharmaceutical
company,  and from  October  2006 to November  2008,  he was the chairman of the
board of ImClone.  Mr. Icahn has been chairman of the board and a director of XO
Holdings, Inc., a telecommunications services provider, since February 2006, and
of its predecessor from January 2003 to February 2006. Mr. Icahn has served as a
Director of Cadus Corporation,  a company engaged in the ownership and licensing
of  yeast-based  drug discovery  technologies  since July 1993. In May 2005, Mr.
Icahn became a director of Blockbuster  Inc., a provider of in-home movie rental
and game  entertainment.  In  October  2005,  Mr.  Icahn  became a  director  of
WestPoint  International,  Inc.,  a  manufacturer  of bed and bath home  fashion
products.  In August 2007, Mr. Icahn became a director of WCI Communities,  Inc.
("WCI"), a homebuilding company, and since September 2007, has been the chairman
of the  board  of WCI.  In  December  2007,  Mr.  Icahn  became  a  director  of
Federal-Mogul Corporation ("Federal-Mogul"),  a supplier of automotive products,
and since January 2008, has been the chairman of the board of Federal-Mogul.  In
April,  2008,  Mr.  Icahn became a director of  Motricity,  Inc., a company that
provides  mobile  content  services and  solutions.  In August,  2008, Mr. Icahn
became a director of Yahoo!  Inc., a company that provides  Internet services to
users, advertisers, publishers, and developers worldwide. Mr. Icahn received his
B.A. from Princeton University.

            DESCRIPTION OF BENEFICIAL OWNERSHIP AND BENEFICIAL OWNERS

     Beckton Corp., a Delaware  corporation  ("Beckton") is the sole stockholder
of Icahn Enterprises G.P. Inc., a Delaware corporation ("Icahn Enterprises GP"),
which is the general  partner of Icahn  Enterprises  Holdings  L.P.,  a Delaware
limited partnership ("Icahn Holdings"). Icahn Holdings is the sole member of IPH
GP LLC, a Delaware  limited  liability  company  ("IPH"),  which is the  general
partner of Icahn Capital L.P., a Delaware limited partnership ("Icahn Capital").
Icahn  Capital is the  general  partner of each of Icahn  Onshore LP, a Delaware
limited  partnership ("Icahn Onshore") and Icahn Offshore LP, a Delaware limited
partnership  ("Icahn  Offshore").  Icahn Onshore is the general partner of Icahn
Partners.  Icahn Offshore is the general partner of each of Icahn Master,  Icahn
Master II and Icahn  Master III.  Beckton is 100 percent  owned by Carl C. Icahn
("Mr.  Icahn," and  collectively  with  Beckton,  Icahn  Enterprises  GP,  Icahn
Holdings,  IPH, Icahn Capital,  Icahn Onshore,  Icahn Offshore,  the "Beneficial
Owners"  and  each of them a  "Beneficial  Owner."  As such,  Mr.  Icahn is in a
position  indirectly to determine the  investment  and voting  decisions made by
each of the Icahn Parties.

     The  principal  business  address  of each  of (i)  Icahn  Offshore,  Icahn
Onshore, Icahn Capital, IPH, Icahn Holdings, Icahn Enterprises GP and Beckton is
White Plains Plaza, 445 Hamilton Avenue - Suite 1210, White Plains, NY 10601 and
(ii) Mr. Icahn is c/o Icahn Capital LP., 767 Fifth Avenue, 47th Floor, New York,
NY 10153.

     Icahn  Offshore  is  primarily  engaged in the  business  of serving as the
general  partner of each of Icahn Master,  Icahn Master II and Icahn Master III.
Icahn  Onshore is  primarily  engaged in the  business of serving as the general
partner of Icahn Partners. Icahn Capital is primarily engaged in the business of
serving as the general partner of each of Icahn Offshore and Icahn Onshore.  IPH
is primarily  engaged in the business of serving as the general partner of Icahn
Capital.  Icahn Holdings is primarily  engaged in the business of holding direct
or indirect interests in various operating  businesses.  Icahn Enterprises GP is
primarily  engaged in the business of serving as the general  partner of each of
Icahn  Enterprises  and Icahn  Holdings.  Beckton  is  primarily  engaged in the
business of holding the capital stock of Icahn Enterprises GP.


     The Icahn Parties and Carl C. Icahn are deemed to beneficially  own, in the
aggregate,  12,971,328 shares of Common Stock, representing  approximately 9.21%
of the  Corporation's  outstanding  shares  of  Common  Stock  (based  upon  the
140,874,975  shares stated to be  outstanding as of April 8, 2009 by the Company
in the Company's Definitive Proxy Statement).

     Icahn Partners has sole voting power and sole dispositive power with regard
to 4,533,433 shares of Common Stock. Each of Icahn Onshore,  Icahn Capital, IPH,
Icahn  Holdings,  Icahn  Enterprises GP, Beckton and Mr. Icahn has shared voting
power and shared dispositive power with regard to such shares.  Icahn Master has
sole voting power and sole dispositive  power with regard to 5,592,721 shares of
Common Stock. Each of Icahn Offshore,  Icahn Capital, IPH, Icahn Holdings, Icahn
Enterprises  GP,  Beckton  and Mr.  Icahn has  shared  voting  power and  shared
dispositive  power with regard to such  shares.  Icahn Master II has sole voting
power and sole  dispositive  power  with  regard to  2,057,967  shares of Common
Stock.  Each of Icahn  Offshore,  Icahn  Capital,  IPH,  Icahn  Holdings,  Icahn
Enterprises  GP,  Beckton  and Mr.  Icahn has  shared  voting  power and  shared
dispositive  power with regard to such shares.  Icahn Master III has sole voting
power and sole dispositive  power with regard to 787,207 shares of Common Stock.
Each of Icahn Offshore,  Icahn Capital,  IPH, Icahn Holdings,  Icahn Enterprises
GP, Beckton and Mr. Icahn has shared voting power and shared  dispositive  power
with regard to such shares.

     Each  of  Icahn  Onshore,   Icahn  Capital,  IPH,  Icahn  Holdings,   Icahn
Enterprises GP, Beckton and Mr. Icahn, by virtue of their relationships to Icahn
Partners,  are deemed to indirectly  beneficially  own the  4,533,433  shares of
Common Stock which Icahn  Partners  directly  beneficially  owns.  Each of Icahn
Offshore,  Icahn Capital, IPH, Icahn Holdings, Icahn Enterprises GP, Beckton and
Mr. Icahn, by virtue of their relationships to Icahn Master, Icahn Master II and
Icahn Master III, is deemed to indirectly  beneficially own the 8,437,895 shares
of Common  Stock  which  Icahn  Master,  Icahn  Master II and Icahn  Master  III
directly beneficially own.



                             TWO YEAR SUMMARY TABLE:


The  following  table  indicates the date of each purchase and sale of shares of
Common Stock, as well as the exercise of any call options,  by Mr. Icahn and his
affiliates  and Dr. Peter Liebert  within the past two years,  and the number of
shares in each such purchase and sale or call option exercise.


                                                             SHARES PURCHASED/
                                                             (SOLD) AND CALL
NAME                                          DATE           OPTIONS EXERCISED
- ----                                          ----           -------------------
High River Limited Partnership              7/25/2007             100,000
High River Limited Partnership              7/26/2007              40,120
High River Limited Partnership              7/27/2007              98,480
High River Limited Partnership              7/30/2007              46,260
High River Limited Partnership              7/31/2007              66,620
High River Limited Partnership               8/1/2007              23,160
High River Limited Partnership               8/2/2007               8,940
High River Limited Partnership              8/30/2007             (23,422)
High River Limited Partnership              8/31/2007             (29,169)
High River Limited Partnership               9/4/2007             (44,070)
High River Limited Partnership               9/5/2007              (3,339)
High River Limited Partnership               9/5/2007             (40,120)
High River Limited Partnership               9/5/2007             (30,701)
High River Limited Partnership               9/6/2007             (45,040)
High River Limited Partnership              9/10/2007             (22,739)
High River Limited Partnership              9/10/2007              (4,661)
High River Limited Partnership              9/11/2007             (11,860)
High River Limited Partnership              9/12/2007              (9,640)
High River Limited Partnership              9/14/2007             (20,099)
High River Limited Partnership              9/14/2007             (31,901)
High River Limited Partnership              9/19/2007             (34,719)
High River Limited Partnership              9/19/2007             (23,160)
High River Limited Partnership              9/19/2007              (2,648)
High River Limited Partnership              9/20/2007                (440)
High River Limited Partnership              9/21/2007              (5,852)
Icahn Partners LP                           7/25/2007             128,314
Icahn Partners LP                           7/26/2007              51,480
Icahn Partners LP                           7/27/2007             126,375
Icahn Partners LP                           7/30/2007              59,360
Icahn Partners LP                           7/31/2007              85,487
Icahn Partners LP                            8/1/2007              30,678
Icahn Partners LP                            8/2/2007              11,494
Icahn Partners LP                           8/30/2007             (30,061)
Icahn Partners LP                           8/31/2007             (37,509)
Icahn Partners LP                            9/4/2007             (31,854)
Icahn Partners LP                            9/5/2007             (28,890)
Icahn Partners LP                            9/5/2007             (51,480)
Icahn Partners LP                            9/5/2007             (21,408)
Icahn Partners LP                            9/6/2007             (61,836)
Icahn Partners LP                           9/10/2007             (37,599)
Icahn Partners LP                           9/11/2007              (5,532)
Icahn Partners LP                           9/11/2007             (10,743)
Icahn Partners LP                           9/12/2007             (13,229)
Icahn Partners LP                           9/14/2007             (35,388)
Icahn Partners LP                           9/14/2007             (35,962)
Icahn Partners LP                           9/19/2007             (49,525)
Icahn Partners LP                           9/19/2007             (30,678)
Icahn Partners LP                           9/19/2007              (2,861)
Icahn Partners LP                           9/20/2007                (604)
Icahn Partners LP                           9/21/2007              (8,029)
Icahn Partners LP                           1/31/2008              78,865
Icahn Partners LP                            2/1/2008              93,018
Icahn Partners LP                            2/6/2008              47,847
Icahn Partners LP                            2/6/2008               1,000
Icahn Partners LP                            2/7/2008             139,515
Icahn Partners LP                            2/8/2008             105,839
Icahn Partners LP                           2/11/2008              18,701
Icahn Partners LP                           2/12/2008             279,088
Icahn Partners LP                           2/13/2008              20,644
Icahn Partners LP                           2/14/2008              74,798
Icahn Partners LP                           2/15/2008             139,401
Icahn Partners LP                           2/19/2008             127,271
Icahn Partners LP                           2/20/2008              74,798
Icahn Partners LP                           2/21/2008              59,838
Icahn Partners LP                           2/22/2008              75,398
Icahn Partners LP                           2/25/2008              44,958
Icahn Partners LP                           2/27/2008             261,809
Icahn Partners LP                           2/28/2008              74,802
Icahn Partners LP                           2/29/2008              88,492
Icahn Partners LP                            3/3/2008             127,470
Icahn Partners LP                            3/4/2008             104,261
Icahn Partners LP                            3/5/2008             128,713
Icahn Partners LP                            3/6/2008             113,739
Icahn Partners LP                           3/10/2008             122,505
Icahn Partners LP                           3/11/2008              56,870
Icahn Partners LP                           3/13/2008              36,598
Icahn Partners LP                            9/9/2008              37,584
Icahn Partners LP                           9/11/2008             888,670(4)
Icahn Partners LP                           9/11/2008             358,423(5)
Icahn Partners LP                           9/25/2008              57,919
Icahn Partners LP                           9/26/2008             141,749
Icahn Partners LP                           9/29/2008              37,599
Icahn Partners LP                           9/30/2008              11,906
Icahn Partners LP                           10/3/2008              47,767
Icahn Partners LP                           1/29/2009             145,314
Icahn Partners LP                           1/30/2009             273,846
Icahn Partners LP                            2/2/2009              36,418
Icahn Partners Master Fund LP               7/25/2007             187,201
Icahn Partners Master Fund LP               7/26/2007              75,105
Icahn Partners Master Fund LP               7/27/2007             184,357
Icahn Partners Master Fund LP               7/30/2007              86,600
Icahn Partners Master Fund LP               7/31/2007             124,713
Icahn Partners Master Fund LP                8/1/2007              41,253
Icahn Partners Master Fund LP                8/2/2007              16,685
Icahn Partners Master Fund LP               8/30/2007             (43,783)
Icahn Partners Master Fund LP               8/31/2007             (54,438)
Icahn Partners Master Fund LP                9/4/2007             (88,980)
Icahn Partners Master Fund LP                9/4/2007             (10,409)
Icahn Partners Master Fund LP                9/5/2007             (64,696)
Icahn Partners Master Fund LP                9/5/2007             (69,270)
Icahn Partners Master Fund LP                9/6/2007             (81,361)
Icahn Partners Master Fund LP               9/10/2007             (33,726)
Icahn Partners Master Fund LP               9/10/2007             (15,771)
Icahn Partners Master Fund LP               9/11/2007             (21,424)
Icahn Partners Master Fund LP               9/12/2007             (17,415)
Icahn Partners Master Fund LP               9/14/2007             (31,990)
Icahn Partners Master Fund LP               9/14/2007             (61,964)
Icahn Partners Master Fund LP               9/19/2007             (62,749)
Icahn Partners Master Fund LP               9/19/2007             (41,253)
Icahn Partners Master Fund LP               9/19/2007              (5,324)
Icahn Partners Master Fund LP               9/20/2007                (794)
Icahn Partners Master Fund LP               9/21/2007             (10,567)
Icahn Partners Master Fund LP               1/31/2008              91,252
Icahn Partners Master Fund LP                2/1/2008             109,421
Icahn Partners Master Fund LP                2/6/2008              56,565
Icahn Partners Master Fund LP                2/6/2008               1,000
Icahn Partners Master Fund LP                2/7/2008             163,220
Icahn Partners Master Fund LP                2/8/2008             123,826
Icahn Partners Master Fund LP               2/11/2008              21,876
Icahn Partners Master Fund LP               2/12/2008             326,512
Icahn Partners Master Fund LP               2/13/2008              24,153
Icahn Partners Master Fund LP               2/14/2008              87,509
Icahn Partners Master Fund LP               2/15/2008             163,089
Icahn Partners Master Fund LP               2/19/2008             148,895
Icahn Partners Master Fund LP               2/20/2008              87,508
Icahn Partners Master Fund LP               2/21/2008              70,006
Icahn Partners Master Fund LP               2/22/2008              88,210
Icahn Partners Master Fund LP               2/25/2008              52,465
Icahn Partners Master Fund LP               2/27/2008             306,273
Icahn Partners Master Fund LP               2/28/2008              87,506
Icahn Partners Master Fund LP               2/29/2008             103,521
Icahn Partners Master Fund LP                3/3/2008              76,164
Icahn Partners Master Fund LP                3/4/2008             118,033
Icahn Partners Master Fund LP                3/5/2008             145,718
Icahn Partners Master Fund LP                3/6/2008             128,762
Icahn Partners Master Fund LP                9/9/2008              43,023
Icahn Partners Master Fund LP               9/11/2008           1,027,533(6)
Icahn Partners Master Fund LP               9/11/2008             431,466(7)
Icahn Partners Master Fund LP               9/11/2008             244,502(8)
Icahn Partners Master Fund LP               9/25/2008              63,488
Icahn Partners Master Fund LP               9/26/2008             162,155
Icahn Partners Master Fund LP               9/29/2008              43,012
Icahn Partners Master Fund LP               9/30/2008              13,621
Icahn Partners Master Fund LP               10/1/2008              23,123
Icahn Partners Master Fund LP               10/3/2008              70,374
Icahn Partners Master Fund LP               11/6/2008             115,198
Icahn Partners Master Fund LP               11/7/2008             362,790
Icahn Partners Master Fund LP               1/29/2009              49,301
Icahn Partners Master Fund LP               1/30/2009             339,204
Icahn Partners Master Fund LP                2/2/2009              22,447
Icahn Partners Master Fund II L.P.          7/25/2007              61,247
Icahn Partners Master Fund II L.P.          7/26/2007              24,573
Icahn Partners Master Fund II L.P.          7/27/2007              60,308
Icahn Partners Master Fund II L.P.          7/30/2007              28,331
Icahn Partners Master Fund II L.P.          7/31/2007              40,802
Icahn Partners Master Fund II L.P.           8/1/2007              15,176
Icahn Partners Master Fund II L.P.           8/2/2007               5,500
Icahn Partners Master Fund II L.P.          8/30/2007             (14,404)
Icahn Partners Master Fund II L.P.          8/31/2007             (17,941)
Icahn Partners Master Fund II L.P.           9/4/2007             (28,902)
Icahn Partners Master Fund II L.P.           9/4/2007              (3,768)
Icahn Partners Master Fund II L.P.           9/5/2007             (20,805)
Icahn Partners Master Fund II L.P.           9/5/2007             (23,373)
Icahn Partners Master Fund II L.P.           9/6/2007             (26,810)
Icahn Partners Master Fund II L.P.          9/10/2007             (10,125)
Icahn Partners Master Fund II L.P.          9/10/2007              (6,201)
Icahn Partners Master Fund II L.P.          9/11/2007              (7,068)
Icahn Partners Master Fund II L.P.          9/12/2007              (5,743)
Icahn Partners Master Fund II L.P.          9/14/2007              (9,319)
Icahn Partners Master Fund II L.P.          9/14/2007             (21,653)
Icahn Partners Master Fund II L.P.          9/19/2007             (19,149)
Icahn Partners Master Fund II L.P.          9/19/2007             (15,176)
Icahn Partners Master Fund II L.P.          9/19/2007              (1,750)
Icahn Partners Master Fund II L.P.          9/20/2007                (263)
Icahn Partners Master Fund II L.P.          9/21/2007              (3,487)
Icahn Partners Master Fund II L.P.          1/31/2008              28,921
Icahn Partners Master Fund II L.P.           2/1/2008              33,747
Icahn Partners Master Fund II L.P.           2/6/2008              16,971
Icahn Partners Master Fund II L.P.           2/6/2008               1,000
Icahn Partners Master Fund II L.P.           2/7/2008              50,969
Icahn Partners Master Fund II L.P.           2/8/2008              38,665
Icahn Partners Master Fund II L.P.          2/11/2008               6,831
Icahn Partners Master Fund II L.P.          2/12/2008             101,959
Icahn Partners Master Fund II L.P.          2/13/2008               7,542
Icahn Partners Master Fund II L.P.          2/14/2008              27,326
Icahn Partners Master Fund II L.P.          2/15/2008              50,927
Icahn Partners Master Fund II L.P.          2/19/2008              46,495
Icahn Partners Master Fund II L.P.          2/20/2008              27,326
Icahn Partners Master Fund II L.P.          2/21/2008              21,861
Icahn Partners Master Fund II L.P.          2/22/2008              27,545
Icahn Partners Master Fund II L.P.          2/25/2008              16,370
Icahn Partners Master Fund II L.P.          2/27/2008              95,636
Icahn Partners Master Fund II L.P.          2/28/2008              27,324
Icahn Partners Master Fund II L.P.          2/29/2008              32,325
Icahn Partners Master Fund II L.P.           3/3/2008              48,284
Icahn Partners Master Fund II L.P.           3/4/2008              38,177
Icahn Partners Master Fund II L.P.           3/5/2008              47,132
Icahn Partners Master Fund II L.P.           3/6/2008              41,649
Icahn Partners Master Fund II L.P.          3/10/2008              44,859
Icahn Partners Master Fund II L.P.          3/11/2008              20,824
Icahn Partners Master Fund II L.P.          3/13/2008              13,401
Icahn Partners Master Fund II L.P.          5/12/2008              36,399
Icahn Partners Master Fund II L.P.          5/13/2008              86,327
Icahn Partners Master Fund II L.P.          5/14/2008              67,854
Icahn Partners Master Fund II L.P.          5/15/2008              79,781
Icahn Partners Master Fund II L.P.          5/21/2008              40,431
Icahn Partners Master Fund II L.P.          5/22/2008              13,819
Icahn Partners Master Fund II L.P.           9/9/2008              14,052
Icahn Partners Master Fund II L.P.          9/11/2008               8,769(9)
Icahn Partners Master Fund II L.P.          9/11/2008             152,160(10)
Icahn Partners Master Fund II L.P.          9/25/2008              20,703
Icahn Partners Master Fund II L.P.          9/26/2008              52,964
Icahn Partners Master Fund II L.P.          9/29/2008              14,048
Icahn Partners Master Fund II L.P.          9/30/2008               4,449
Icahn Partners Master Fund II L.P.          10/1/2008              13,413
Icahn Partners Master Fund II L.P.          10/3/2008              23,076
Icahn Partners Master Fund II L.P.          11/7/2008              25,022
Icahn Partners Master Fund II L.P.          1/29/2009             365,314
Icahn Partners Master Fund II L.P.          1/30/2009             125,320
Icahn Partners Master Fund III L.P          7/25/2007              23,238
Icahn Partners Master Fund III L.P          7/26/2007               9,322
Icahn Partners Master Fund III L.P          7/27/2007              22,880
Icahn Partners Master Fund III L.P          7/30/2007              10,749
Icahn Partners Master Fund III L.P          7/31/2007              15,478
Icahn Partners Master Fund III L.P           8/1/2007               5,533
Icahn Partners Master Fund III L.P           8/2/2007               2,081
Icahn Partners Master Fund III L.P          8/30/2007              (5,440)
Icahn Partners Master Fund III L.P          8/31/2007              (6,790)
Icahn Partners Master Fund III L.P           9/4/2007             (11,008)
Icahn Partners Master Fund III L.P           9/4/2007              (1,362)
Icahn Partners Master Fund III L.P           9/5/2007              (7,960)
Icahn Partners Master Fund III L.P           9/5/2007              (8,758)
Icahn Partners Master Fund III L.P           9/6/2007             (10,153)
Icahn Partners Master Fund III L.P          9/10/2007              (3,969)
Icahn Partners Master Fund III L.P          9/10/2007              (2,209)
Icahn Partners Master Fund III L.P          9/11/2007              (2,673)
Icahn Partners Master Fund III L.P          9/12/2007              (2,173)
Icahn Partners Master Fund III L.P          9/14/2007              (3,694)
Icahn Partners Master Fund III L.P          9/14/2007              (8,030)
Icahn Partners Master Fund III L.P          9/19/2007              (7,448)
Icahn Partners Master Fund III L.P          9/19/2007              (5,533)
Icahn Partners Master Fund III L.P          9/19/2007                (663)
Icahn Partners Master Fund III L.P          9/20/2007                 (99)
Icahn Partners Master Fund III L.P          9/21/2007              (1,319)
Icahn Partners Master Fund III L.P.         1/31/2008              10,962
Icahn Partners Master Fund III L.P.          2/1/2008              12,814
Icahn Partners Master Fund III L.P.          2/6/2008               5,817
Icahn Partners Master Fund III L.P.          2/6/2008               1,000
Icahn Partners Master Fund III L.P.          2/7/2008              19,336
Icahn Partners Master Fund III L.P.          2/8/2008              14,670
Icahn Partners Master Fund III L.P.         2/11/2008               2,592
Icahn Partners Master Fund III L.P.         2/12/2008              38,681
Icahn Partners Master Fund III L.P.         2/13/2008               2,861
Icahn Partners Master Fund III L.P.         2/14/2008              10,367
Icahn Partners Master Fund III L.P.         2/15/2008              19,321
Icahn Partners Master Fund III L.P.         2/19/2008              17,639
Icahn Partners Master Fund III L.P.         2/20/2008              10,368
Icahn Partners Master Fund III L.P.         2/21/2008               8,295
Icahn Partners Master Fund III L.P.         2/22/2008              10,447
Icahn Partners Master Fund III L.P.         2/25/2008               6,207
Icahn Partners Master Fund III L.P.         2/27/2008              36,282
Icahn Partners Master Fund III L.P.         2/28/2008              10,368
Icahn Partners Master Fund III L.P.         2/29/2008              12,262
Icahn Partners Master Fund III L.P.          3/3/2008              19,164
Icahn Partners Master Fund III L.P.          3/4/2008              14,529
Icahn Partners Master Fund III L.P.          3/5/2008              17,937
Icahn Partners Master Fund III L.P.          3/6/2008              15,850
Icahn Partners Master Fund III L.P.         3/10/2008              17,072
Icahn Partners Master Fund III L.P.         3/11/2008               7,924
Icahn Partners Master Fund III L.P.         3/13/2008               5,100
Icahn Partners Master Fund III L.P.         5/12/2008              13,835
Icahn Partners Master Fund III L.P.         5/13/2008              32,813
Icahn Partners Master Fund III L.P.         5/14/2008              25,794
Icahn Partners Master Fund III L.P.         5/15/2008              30,324
Icahn Partners Master Fund III L.P.         5/21/2008              15,228
Icahn Partners Master Fund III L.P.         5/22/2008               5,391
Icahn Partners Master Fund III L.P.          9/9/2008               5,341
Icahn Partners Master Fund III L.P.         9/11/2008               2,796(11)
Icahn Partners Master Fund III L.P.         9/11/2008              57,951(12)
Icahn Partners Master Fund III L.P.         9/25/2008               7,890
Icahn Partners Master Fund III L.P.         9/26/2008              20,132
Icahn Partners Master Fund III L.P.         9/29/2008               5,341
Icahn Partners Master Fund III L.P.         9/30/2008               1,691
Icahn Partners Master Fund III L.P.         10/1/2008               5,837
Icahn Partners Master Fund III L.P.         10/3/2008               8,783
Icahn Partners Master Fund III L.P.         11/7/2008              12,188
Icahn Partners Master Fund III L.P.         1/29/2009             140,071
Icahn Partners Master Fund III L.P.         1/30/2009              47,936
Dr. Peter Liebert                            2/9/2009               1,000
Dr. Peter Liebert                           2/10/2009               1,000



_________________________
(4)  Icahn  Partners  acquired  these  shares upon  exercise of call  options as
     described on Attachment I-A to this Annex A.

(5)  The Icahn  Partners  acquired these shares upon exercise of call options as
     described on Attachment I-B to this Annex A.

(6)  The Icahn Master  acquired  these  shares upon  exercise of call options as
     described on Attachment I-A to this Annex A.

(7)  Icahn  Master  acquired  these  shares  upon  exercise  of call  options as
     described on Attachment I-B to this Annex A.

(8)  Icahn  Master  acquired  these  shares  upon  exercise  of call  options as
     described on Attachment I-C to this Annex A.

(9)  Icahn  Master II acquired  these  shares upon  exercise of call  options as
     described on Attachment I-A to this Annex A.

(10) Icahn  Master II acquired  these  shares upon  exercise of call  options as
     described on Attachment I-B to this Annex A.

(11) Icahn  Master III acquired  these  shares upon  exercise of call options as
     described on Attachment I-A to this Annex A.

(12) Icahn  Master III acquired  these  shares upon  exercise of call options as
     described on Attachment I-B to this Annex A.







Shares of Common Stock  purchased by each of the Icahn Parties are maintained in
margin accounts that include  positions in securities in addition to the shares.
As of [ ], the  indebtedness  of the margin  account of each of Icahn  Partners,
Icahn Master,  Icahn Master II and Icahn Master III was  approximately  $, $, $,
and $, respectively.






                                                                         ANNEX A
                                                                  ATTACHMENT 1-A

The following are American call options  purchased by the Icahn  Parties,  which
were written by Merrill  Lynch  International  with a $22.50 strike price and an
expiration  date of March 10, 2010,  and which provide for physical  settlement.
These are further described in the chart set forth below. On September 11, 2008,
the Icahn  Parties  exercised  all of the call  options  described  in the chart
below.

                                                       NUMBER OF
                                                       SHARES
                                                       SUBJECT TO
NAME                                      DATE         OPTION           PREMIUM
- ----                                      ----         ------           -------

Icahn Partners LP                       5/12/2008       98,799        680,665.83
Icahn Partners LP                       5/12/2008        7,565         51,729.47
Icahn Partners LP                       5/13/2008      234,322      1,562,646.55
Icahn Partners LP                       5/14/2008      184,122      1,307,487.15
Icahn Partners LP                       5/15/2008      216,614      1,705,965.22
Icahn Partners LP                       5/21/2008      109,365        910,113.66
Icahn Partners LP                       5/22/2008       37,883        317,648.96
Icahn Partners Master Fund LP           5/12/2008      112,467        774,830.15
Icahn Partners Master Fund LP           5/12/2008       24,534        167,763.49
Icahn Partners Master Fund LP           5/13/2008      266,738      1,778,822.37
Icahn Partners Master Fund LP           5/14/2008      209,729      1,489,327.57
Icahn Partners Master Fund LP           5/15/2008      246,446      1,940,910.12
Icahn Partners Master Fund LP           5/21/2008      124,712      1,037,828.32
Icahn Partners Master Fund LP           5/22/2008       42,907        359,775.20
Icahn Partners Master Fund II L.P.      5/12/2008        8,769         59,962.42
Icahn Partners Master Fund III, L.P.    5/12/2008        2,796         19,119.05






                                                                         ANNEX A
                                                                  ATTACHMENT 1-B

The following are American call options  purchased by the Icahn  Parties,  which
were written by Merrill  Lynch  International  with a $14.25 strike price and an
expiration date of September 7, 2010, and which provide for physical settlement.
These are further described in the chart set forth below. On September 11, 2008,
the Icahn  Parties  exercised  all of the call  options  described  in the chart
below.

                                                       NUMBER OF
                                                       SHARES
                                                       SUBJECT TO
NAME                                      DATE         OPTION           PREMIUM
- ----                                      ----         ------           -------
Icahn Partners LP                        9/2/2008      302,048      2,254,697.71
Icahn Partners LP                        9/3/2008       56,375        418,477.26
Icahn Partners Master Fund LP            9/2/2008      366,932      2,739,037.30
Icahn Partners Master Fund LP            9/3/2008       64,534        479,042.34
Icahn Partners Master Fund II L.P.       9/2/2008      131,081        978,480.34
Icahn Partners Master Fund II L.P.       9/3/2008       21,079        156,471.52
Icahn Partners Master Fund III L.P.      9/2/2008       49,939        372,779.65
Icahn Partners Master Fund III L.P.      9/3/2008        8,012         59,473.88





                                                                         ANNEX A
                                                                  ATTACHMENT 1-C

The following are American call options  purchased by the Icahn  Parties,  which
were  written by UBS AG with a $16.15  strike  price and an  expiration  date of
September 7, 2010, and which provide for physical settlement.  These are further
described in the chart set forth below. On September 11, 2008, the Icahn Parties
exercised all of the call options described in the chart below.

                                                       NUMBER OF
                                                       SHARES
                                                       SUBJECT TO
NAME                                      DATE         OPTION           PREMIUM
- ----                                      ----         ------           -------
Icahn Partners Master Fund LP           3/10/2008      138,688      1,164,798.91
Icahn Partners Master Fund LP           3/11/2008       64,382        517,792.23
Icahn Partners Master Fund LP           3/13/2008       41,432        359,563.47





                                                                         ANNEX A
                                                                  ATTACHMENT 1-D

The following are European put options bought by the Icahn  Parties,  which were
written by Merrill  Lynch  International  and have a $22.50  strike price and an
expiration  date of March 10, 2010, and provide for cash settlement only and are
further described in the chart set forth below. On September 11, 2008, the Icahn
Parties  exercised all of the call options  described in Annex A Attachment 1-A,
and upon exercise of the call options,  all of the put options  described  below
expired pursuant to their terms.

                                                                     OPTION
NAME                                       DATE       QUANTITY       PREMIUM ($)
- ----                                       ----       --------       -----------

Icahn Partners LP                       5/12/2008       98,799            987.99
Icahn Partners LP                       5/12/2008        7,565             75.65
Icahn Partners LP                       5/13/2008      234,322          2,343.22
Icahn Partners LP                       5/14/2008      184,122          1,841.22
Icahn Partners LP                       5/15/2008      216,614          2,166.14
Icahn Partners LP                       5/21/2008      109,365          1,093.65
Icahn Partners LP                       5/22/2008       37,883            378.83
Icahn Partners Master Fund LP           5/12/2008      112,467          1,124.67
Icahn Partners Master Fund LP           5/12/2008       24,534            245.34
Icahn Partners Master Fund LP           5/13/2008      266,738          2,667.38
Icahn Partners Master Fund LP           5/14/2008      209,729          2,097.29
Icahn Partners Master Fund LP           5/15/2008      246,446          2,464.46
Icahn Partners Master Fund LP           5/21/2008      124,712          1,247.12
Icahn Partners Master Fund LP           5/22/2008       42,907            429.07
Icahn Partners Master Fund II L.P.      5/12/2008        8,769             87.69
Icahn Partners Master Fund III, L.P.    5/12/2008        2,796             27.96





                                                                         ANNEX A
                                                                  ATTACHMENT 1-E

The following are European put options bought by the Icahn  Parties,  which were
written by Merrill  Lynch  International  and have a $14.25  strike price and an
expiration  date of September 7, 2010 and provide for cash  settlement  only and
are further  described in the chart set forth below.  On September 11, 2008, the
Icahn Parties exercised all of the call options described in Annex A Attachments
1-B, and upon  exercise of the call  options,  all of the put options  described
below expired pursuant to their terms.


                                                                     OPTION
NAME                                       DATE       QUANTITY       PREMIUM ($)
- ----                                       ----       --------       -----------
Icahn Partners LP                        9/2/2008      302,048          3,020.48
Icahn Partners LP                        9/3/2008       56,375            563.75
Icahn Partners Master Fund LP            9/2/2008      366,932          3,669.32
Icahn Partners Master Fund LP            9/3/2008       64,534            645.34
Icahn Partners Master Fund II L.P.       9/2/2008      131,081          1,310.81
Icahn Partners Master Fund II L.P.       9/3/2008       21,079            210.79
Icahn Partners Master Fund III, L.P.     9/2/2008       49,939            499.39
Icahn Partners Master Fund III, L.P.     9/3/2008        8,012             80.12





                                                                         ANNEX A
                                                                  ATTACHMENT 1-F

The following are European put options bought by the Icahn  Parties,  which were
written by UBS AG and have a $16.15 strike price and an expiration date of March
10, 2010 and provide for cash settlement  only and are further  described in the
chart set forth below. On September 11, 2008, the Icahn Parties exercised all of
the call options  described in Annex A Attachments 1-C, and upon exercise of the
call options,  all of the put options  described below expired pursuant to their
terms.

                                                                     OPTION
NAME                                       DATE       QUANTITY       PREMIUM ($)
- ----                                       ----       --------       -----------

Icahn Partners Master Fund LP           3/10/2008      138,688          1,386.88
Icahn Partners Master Fund LP           3/11/2008       64,382            643.82
Icahn Partners Master Fund LP           3/13/2008       41,432            414.32





                                                                         ANNEX B

                           [FORM OF NOMINEE AGREEMENT]

                                ICAHN PARTNERS LP
                          ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                        ICAHN PARTNERS MASTER FUND III LP

                                                     January 28, 2009

[NAME OF NOMINEE]


Dear  ___________:


     This will confirm our understanding as follows:

     You agree that you are willing, should we so elect, to become a member of a
slate of nominees  (the  "Slate") to stand for  election as  directors of Amylin
Pharmaceuticals,  Inc.  ("Amylin")  in  connection  with a  proxy  contest  with
management  of Amylin in respect of the  election of  directors of Amylin at the
2009 Annual Meeting of Stockholders of Amylin (the "Annual  Meeting"),  expected
to be held in the Spring of 2009, or a special meeting of stockholders of Amylin
called for a similar purpose (the "Proxy Contest").

     Icahn  Partners LP, Icahn Partners  Master Fund LP, Icahn  Partners  Master
Fund II LP and Icahn Partners Master Fund III LP (collectively,  "Icahn"), agree
to pay the costs of the Proxy Contest.

     In addition, upon our filing of a preliminary proxy statement with the SEC,
which  indicates  that Icahn  intends to nominate you for election at the Annual
Meeting,  you will be paid $25,000 by Icahn unless you are elected to serve as a
director of Amylin at the Annual Meeting or a special meeting of stockholders of
Amylin called for a similar  purpose or in  connection  with a settlement of the
Proxy  Contest  by Icahn and  Amylin,  in which  case you will not  receive  any
payment from Icahn in connection with the Proxy Contest. Payment to you pursuant
to this paragraph,  if any, will be made by Icahn,  subject to the terms hereof,
upon the  earliest of (i) the  certification  of the results of the  election in
respect of the Proxy Contest,  (ii) the settlement of the Proxy Contest by Icahn
and Amylin, or (iii) the withdrawal of the Proxy Contest by Icahn.*

     You  understand  that it may be difficult,  if not  impossible,  to replace
nominees  who,  such as  yourself,  have  agreed to serve on the Slate and later
change their minds and determine not to seek election. Accordingly, the Slate is
relying upon your agreement to seek election. In that connection,  you are being
supplied with a questionnaire  in which you will provide Icahn with  information
necessary for Icahn to make appropriate disclosure both to Amylin and for use in
creating the proxy material to be sent to stockholders of Amylin and to be filed
with the Securities and Exchange  Commission.  You have agreed that (i) you will
immediately  complete and sign the  questionnaire and return it to Tara Keating,
Assistant General Counsel,  Icahn Enterprises LP, 767 Fifth Avenue,  Suite 4700,
New  York,  NY  10153,  Tel:  (212)  702-4365,   Fax:  (212)  688-1158,   Email:
tkeating@sfire.com  and (ii) your responses to the questions  contained  therein
will be true and correct in all  respects.  In  addition,  you have agreed that,
concurrently  with your execution of this letter,  you will execute the attached
instrument  directed  to  Amylin  informing  Amylin  that you  consent  to being
nominated by Icahn for election as a director of Amylin and, if elected, consent
to serving as a director of Amylin. Upon being notified that we have chosen you,
we may forward  that  consent and your  completed  questionnaire  (or  summaries
thereof) to Amylin.

_________________________
*    This paragraph is not contained in Dr. Denner's Nominee Agreement.





     Icahn hereby agrees that, so long as you actually serve on the Slate, Icahn
will  defend,  indemnify  and hold you  harmless  from and  against  any and all
losses, damages, penalties,  judgments, awards, liabilities, costs, expenses and
disbursements (including, without limitation, reasonable attorneys' fees, costs,
expenses and  disbursements)  incurred by you in the event that (i) you become a
party,  or  are  threatened  to  be  made  a  party,  to  any  civil,  criminal,
administrative or arbitrative action, suit or proceeding, and any appeal thereof
relating solely to your role as a nominee for director of Amylin on the Slate (a
"Proceeding")  or (ii) you are  called to testify  or give a  deposition  in any
Proceeding  (whether or not you are a party or are threatened to be made a party
to such  Proceeding),  including,  in each case,  the  advancement to you of all
reasonable  attorneys' costs and expenses incurred by you in connection with any
Proceeding.  Your right of  indemnification  hereunder shall continue (i) in the
event that Icahn  determines  to withdraw the Slate or remove you from the Slate
and (ii) after the  election  has taken  place but only for events  which  occur
prior to such  election  and  subsequent  to the date  hereof.  Anything  to the
contrary herein  notwithstanding,  Icahn is not  indemnifying you for any action
taken  by you or on your  behalf  which  occurs  prior  to the  date  hereof  or
subsequent  to the Annual  Meeting or such  earlier  time as you are no longer a
nominee of the Slate for  election to  Amylin's  Board of  Directors  or for any
actions taken by you as a director of Amylin, if you are elected. Nothing herein
shall be construed to provide you an  indemnity:  (i) in the event you are found
to have  engaged in a  violation  of any  provision  of state or federal  law in
connection  with the Proxy Contest unless you  demonstrate  that your action was
taken in good  faith and in a manner  you  reasonably  believed  to be in or not
opposed to the best  interests of electing the Slate;  or (ii) if you acted in a
manner which  constitutes gross negligence or willful  misconduct.  In the event
that you shall make any claim for indemnification  hereunder, you shall promptly
notify Icahn in the event of any third-party claims actually made against you or
known by you to be  threatened.  In  addition,  with  respect to any such claim,
Icahn shall be entitled to control your  defense  with counsel  chosen by Icahn.
Icahn  shall not be  responsible  for any  settlement  of any claim  against you
covered by this indemnity without its prior written consent.  However, Icahn may
not enter into any settlement of any such claim without your consent unless such
settlement  includes a release of you from any and all  liability  in respect of
such claim.

     Each of us recognizes  that should you be elected to the Board of Directors
of Amylin all of your activities and decisions as a director will be governed by
applicable law and subject to your fiduciary duty to the  stockholders of Amylin
and, as a result,  that there is, and can be, no agreement between you and Icahn
which governs the decisions which you will make as a director of Amylin.

     Should the foregoing agree with your  understanding,  please so indicate in
the space provided below,  whereupon this letter will become a binding agreement
between us.

                                            Very truly yours,

                                            ICAHN PARTNERS LP


                                            By: __________________________
                                                Name: Edward E. Mattner
                                                Title: Authorized Signatory

                                            ICAHN PARTNERS MASTER FUND LP


                                            By: __________________________
                                                Name: Edward E. Mattner
                                                Title: Authorized Signatory

                                            ICAHN PARTNERS MASTER FUND II LP


                                            By: __________________________
                                                Name: Edward E. Mattner
                                                Title: Authorized Signatory

                                            ICAHN PARTNERS MASTER FUND III LP


                                            By: __________________________
                                                Name: Edward E. Mattner
                                                Title: Authorized Signatory


Agreed to and Accepted as of
the date first above written:


- --------------------------
Name:





                                    IMPORTANT


     1. If your shares of Common  Stock are held in your own name,  please mark,
date and mail the enclosed GOLD proxy card to our Proxy  Solicitor,  D.F. King &
Co., Inc., in the postage-paid envelope provided.

     2. If your shares of Common Stock are held in the name of a brokerage firm,
bank nominee or other institution,  only it can vote such shares of Common Stock
and only upon receipt of your  specific  instructions.  Accordingly,  you should
contact the person responsible for your account and give instructions for a GOLD
proxy card to be signed representing your shares of Common Stock.

     3. If you have  already  submitted a white or blue proxy card to Amylin for
the Annual  Meeting,  you may change your vote to a vote FOR the election of the
Nominee by marking,  signing,  dating and returning the enclosed GOLD proxy card
for the  Annual  Meeting,  which  must be dated  after  any  proxy  you may have
submitted  to Amylin.  You may also submit your  later-dated  proxy by using the
enclosed  GOLD proxy card to vote by telephone or by Internet.  ONLY YOUR LATEST
DATED PROXY FOR THE ANNUAL MEETING WILL COUNT AT THE ANNUAL MEETING.


     If you have any  questions  or require any  assistance  in  executing  your
proxy, please call:

                              D.F. KING & CO., INC.
                   STOCKHOLDERS CALL TOLL-FREE: (800) 488-8075
                 BANKS AND BROKERAGE FIRMS CALL: (212) 269-5550




                         PROXY CARD [PRELIMINARY COPY]
                          AMYLIN PHARMACEUTICALS, INC.
                         ANNUAL MEETING OF STOCKHOLDERS
                                    [ ], 2009

GOLD PROXY CARD                                                  GOLD PROXY CARD
                           THIS PROXY IS SOLICITED BY:
                                ICAHN PARTNERS LP
                          ICAHN PARTNERS MASTER FUND LP
                        ICAHN PARTNERS MASTER FUND II LP
                        ICAHN PARTNERS MASTER FUND III LP

VOTE BY INTERNET                 VOTE BY TELEPHONE             VOTE BY MAIL
      [ ]                               [ ]
Have this form available    Call toll-free on a touch-    Mark, date and sign
when you visit the secure   tone phone, 24 hours a day,   this voting direction
voting site and follow the  seven days a week.  Have      form and mail promptly
simple instructions.  You   this form available when      in the postage-paid
may elect to receive an     you call and follow the       envelope.  Do not
e-mail confirmation of      simple instructions.          return the card if you
your vote.                                                vote by telephone or
                                                          by Internet.


  YOUR VOTE, WHETHER BY INTERNET, TELEPHONE OR MAIL, MUST BE RECEIVED NO LATER
    THAN [ ]PM, EASTERN TIME, ON [ ], TO BE INCLUDED IN THE VOTING RESULTS.


The undersigned  hereby appoints and constitutes each of Alexander J. Denner and
Mayu Sris (acting alone or together) as proxies, with full power of substitution
in each, to represent the  undersigned at the Annual Meeting of  Stockholders of
Amylin  Pharmaceuticals,  Inc.  ("Amylin")  to be held  on May 27,  2009 at 4575
Eastgate  Mall,  San  Diego,  CA  92121  at 8:30  a.m.  local  time,  and at any
adjournment or postponement  or  continuations  thereof (the "Annual  Meeting"),
hereby revoking any proxies previously given, to vote all shares of Common Stock
of Amylin  held or owned by the  undersigned  as  directed  below,  and in their
discretion  upon such other  matters as may come before the  meeting  (provided,
however,   that  the  persons   named  above  will  be  permitted  to  use  such
discretionary  authority  only for matters  which they do not know, a reasonable
time before the solicitation, are to be presented at the meeting).

     IF NO  DIRECTION  IS MADE,  THE PERSONS  NAMED IN THIS GOLD PROXY CARD WILL
     VOTE YOUR SHARES:  FOR DR. ALEXANDER J. DENNER, DR. THOMAS F. DEUEL AND DR.
     PETER  LIEBERT FOR  DIRECTOR;  FOR THE PERSONS WHO HAVE BEEN  NOMINATED  BY
     EASTBOURNE CAPITAL MANAGEMENT L.L.C.  ("EASTBOURNE") TO SERVE AS DIRECTORS,
     OTHER THAN  MARINA S.  BOZILENKO,  CHARLES  M.  FLEISCHMAN  AND  WILLIAM A.
     NUERGE;  (V) FOR THE PERSONS WHO HAVE BEEN  NOMINATED BY AMYLIN TO SERVE AS
     DIRECTORS,  OTHER THAN  JOSEPH C.  COOK,  JR.,  JAMES R. GAVIN III,  JAY S.
     SKYLER, JOSEPH P. SULLIVAN AND JAMES N. WILSON; AND (V) FOR PROPOSALS 2, 3,
     4 AND 5.


                      SIGN, DATE AND MAIL YOUR PROXY TODAY


                (CONTINUED AND TO BE SIGNED ON THE REVERSE SIDE.)






ICAHN  PARTNERS,  ICAHN  MASTER,  ICAHN  MASTER  II,  AND ICAHN  MASTER III EACH
RECOMMEND A VOTE "FOR" THE ELECTION OF THE  NOMINEES  LISTED IN PROPOSAL 1 BELOW
AND "FOR" PROPOSALS 2, 3, 4 AND 5.


[PRELIMINARY COPY]

[X] PLEASE MARK VOTES AS IN THIS EXAMPLE.

    STOCKHOLDERS ARE URGED TO DATE, MARK, SIGN, AND RETURN THIS PROXY.

    YOUR VOTE IS VERY IMPORTANT TO US.


1.  Election of directors -- Nominees:    [ ]          [ ]            [ ]
    (01) Dr. Alexander J. Denner          FOR ALL      WITHHELD       FOR ALL
    (02) Dr. Thomas F. Deuel              NOMINEES     FROM ALL       EXCEPT
    (03) Dr. Peter Liebert                             NOMINEES

     The persons who have been  nominated by  Eastbourne  to serve as directors,
     other than  Marina S.  Bozilenko,  Charles  M.  Fleischman  and  William A.
     Nuerge.

     The persons who have been nominated by Amylin to serve as directors,  other
     than Joseph C. Cook,  Jr.,  James R. Gavin III,  Jay S.  Skyler,  Joseph P.
     Sullivan and James N. Wilson.

     The  Icahn  Parties  are NOT  seeking  authority  to vote  for and WILL NOT
     exercise  any  authority  to vote  for  Marina  S.  Bozilenko,  Charles  M.
     Fleischman, William A. Nuerge, Joseph C. Cook, Jr., James R. Gavin III, Jay
     S. Skyler,  Joseph P.  Sullivan and James N. Wilson.  There is no assurance
     that any of the Eastbourne nominees or Amylin nominees,  respectively, will
     serve as directors with each other or will serve as directors if any or all
     of the Icahn Parties'  nominees are elected to the Board.  You should refer
     to the proxy  statement and form of proxy  distributed  by  Eastbourne  and
     Amylin  for the names,  background,  qualifications  and other  information
     concerning the Eastbourne and Amylin nominees.

     NOTE: IF YOU DO NOT WISH YOUR SHARES VOTED "FOR" A PARTICULAR NOMINEE, MARK
     THE "FOR ALL EXCEPT" BOX AND WRITE THE NAME(S) OF THE NOMINEE(S) YOU DO NOT
     SUPPORT ON THE LINE BELOW. YOU MAY ALSO WITHHOLD  AUTHORITY TO VOTE FOR THE
     PERSONS WHO HAVE BEEN  NOMINATED BY EASTBOURNE TO SERVE AS DIRECTORS  OTHER
     THAN MARINA S.  BOZILENKO,  CHARLES M. FLEISCHMAN AND WILLIAM A. NUERGE AND
     YOU MAY ALSO  WITHHOLD  AUTHORITY  TO VOTE FOR THE  PERSONS  WHO HAVE  BEEN
     NOMINATED BY AMYLIN TO SERVE AS DIRECTORS  OTHER THAN JOSEPH C. COOK,  JR.,
     JAMES R. GAVIN III, JAY S. SKYLER,  JOSEPH P.  SULLIVAN AND JAMES N. WILSON
     BY WRITING THE NAMES OF SUCH NOMINEES BELOW.  YOUR SHARES WILL BE VOTED FOR
     THE REMAINING NOMINEE(S).


_______________________________________________________________________________



2.  Amylin's 2009 Equity Incentive Plan             [ ]      [ ]         [ ]
                                                    FOR      AGAINST     ABSTAIN


3.  Amendment to the 2001 Employee Stock            [ ]      [ ]         [ ]
    Purchase Plan                                   FOR      AGAINST     ABSTAIN


4.  Ratification of appointment of Independent      [ ]      [ ]         [ ]
    Registered Public Accounting Firm               FOR      AGAINST     ABSTAIN


5.  North Dakota Reincorporation Proposal           [ ]      [ ]         [  ]
                                                    FOR      AGAINST     ABSTAIN


    Please be sure to sign and date this Proxy.


    --------------------------------------------------   ------------------
    SIGNATURE(S) OF STOCKHOLDER(S)                       DATE

    --------------------------------------------------   ------------------
    SIGNATURE(S) IF HELD JOINTLY


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    TITLE, IF ANY