UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM N-CSR CERTIFIED SHAREHOLDER REPORT OF REGISTERED MANAGEMENT INVESTMENT COMPANIES Investment Company Act file number 811-4932 John Hancock World Fund (Exact name of registrant as specified in charter) 101 Huntington Avenue, Boston, Massachusetts 02199 (Address of principal executive offices) (Zip code) Alfred P. Ouellette Senior Attorney and Assistant Secretary 101 Huntington Avenue Boston, Massachusetts 02199 (Name and address of agent for service) Registrant's telephone number, including area code: 617-375-1513 Date of fiscal year end: October 31 Date of reporting period: April 30, 2005 ITEM 1. REPORT TO SHAREHOLDERS. SEMIANNUAL REPORT John Hancock Biotechnology Fund April 30, 2005 YOUR EXPENSES These examples are intended to help you understand your ongoing operating expenses. Understanding fund expenses As a shareholder of the Fund, you incur two types of costs: * Transaction costs which include sales charges (loads) on purchases or redemptions (varies by share class), minimum account fee charge, etc. * Ongoing operating expenses including management fees, distribution and service fees (if applicable) and other fund expenses. We are going to present only your ongoing operating expenses here. Actual expenses/actual returns This example is intended to provide information about your fund's actual ongoing operating expenses, and is based on your fund's actual return. It assumes an account value of $1,000.00 on October 31, 2004, with the same investment held until April 30, 2005. Account value Expenses paid $1,000.00 Ending value during period on 10-31-04 on 4-30-05 ended 4-30-05 1 Class A $965.60 $7.80 Class B 962.20 11.19 Class C 962.20 11.19 Together with the value of your account, you may use this information to estimate the operating expenses that you paid over the period. Simply divide your account value at April 30, 2005 by $1,000.00, then multiply it by the "expenses paid" for your share class from the table above. For example, for an account value of $8,600.00, the operating expenses should be calculated as follows: Example -- -- -- -- | My account value / | | "expenses paid" | My | / $1,000.00 = 8.6 | X $| | = actual | $8,600.00 / | | from table | expenses -- -- -- -- Hypothetical example for comparison purposes This table allows you to compare your fund's ongoing operating expenses with those of any other fund. It provides an example of the Fund's hypothetical account values and hypothetical expenses based on each class's actual expense ratio and an assumed 5% annual return before expenses (which is not your fund's actual return). It assumes an account value of $1,000.00 on October 31, 2004, with the same investment held until April 30, 2005. Look in any other fund shareholder report to find its hypothetical example and you will be able to compare these expenses. Account value Expenses paid $1,000.00 Ending value during period on 10-31-04 on 4-30-05 ended 4-30-05 1 Class A $1,016.86 $8.00 Class B 1,013.39 11.48 Class C 1,013.39 11.48 Remember, these examples do not include any transaction costs, such as sales charges; therefore, these examples will not help you to determine the relative total costs of owning different funds. If transaction costs were included, your expenses would have been higher. See the prospectus for details regarding transaction costs. 1 Expenses are equal to the Fund's annualized expense ratio of 1.60%, 2.30% and 2.30% for Class A, Class B and Class C, respectively, multiplied by the average account value over the period, multiplied by number of days in most recent fiscal half-year/365 or 366 (to reflect the one-half year period). John Hancock Biotechnology Fund Securities owned by the Fund on April 30, 2005 (unaudited) Issuer Shares Value - ------------------------------------------------------------------------------ Common stocks 94.55% $15,161,388 - ------------------------------------------------------------------------------ (Cost $13,613,201) Biotechnology 60.13% 9,642,331 - ------------------------------------------------------------------------------ Abgenix, Inc. (I) 32,000 223,040 Alkermes, Inc. (I) 10,000 112,500 Amgen, Inc. (I) 42,000 2,444,820 Amylin Pharmaceuticals, Inc. (I)(L) 5,000 85,000 Applera Corp.-Celera Genomics Group (I) 30,000 276,000 Celgene Corp. (I) 20,000 758,200 Cephalon, Inc. (I) 5,000 219,500 Charles River Laboratories International, Inc. (I) 4,000 189,480 Eyetech Pharmaceuticals, Inc. (I)(L) 7,500 172,425 Genentech, Inc. (I)(L) 12,500 886,750 Genzyme Corp. (I) 16,000 937,760 Gilead Sciences, Inc. (I) 22,000 816,200 Human Genome Sciences, Inc. (I) 25,000 258,500 Invitrogen Corp. (I) 2,000 146,540 Life Sciences Research, Inc. (I) 15,000 193,500 Martek Biosciences Corp. (I) 5,000 191,350 Medarex, Inc. (I) 32,500 230,100 Nabi Biopharmaceuticals (I) 9,900 107,910 Neurocrine Biosciences, Inc. (I) 6,000 209,760 Protein Design Labs, Inc. (I) 23,000 411,240 Sepracor, Inc. (I) 50 2,996 Telik, Inc. (I)(L) 12,000 194,400 Vicuron Pharmaceuticals, Inc. (I) 20,000 327,000 ZymoGenetics, Inc. (I) 16,000 247,360 Health Care Equipment 11.87% 1,902,643 - ------------------------------------------------------------------------------ Boston Scientific Corp. (I) 11,600 343,128 Caliper Life Sciences, Inc. (I) 50,000 289,500 Fisher Scientific International, Inc. (I) 3,500 207,830 Gen-Probe, Inc. (I) 10,000 501,900 Hospira, Inc. (I) 16,700 560,285 Health Care Services 6.94% 1,112,755 - ------------------------------------------------------------------------------ Accredo Health, Inc. (I) 10,000 453,000 Cytokinetics, Inc. (I) 17,000 83,470 Nektar Therapeutics (I) 22,000 313,720 Onyx Pharmaceuticals, Inc. (I) 8,500 262,565 Health Care Supplies 1.07% 171,650 - ------------------------------------------------------------------------------ Bioenvision, Inc. (I) 10,000 64,000 Serologicals Corp. (I) 5,000 107,650 Pharmaceuticals 14.54% $2,332,009 - ------------------------------------------------------------------------------ ARIAD Pharmaceuticals, Inc. (I) 25,000 153,500 Aspreva Pharmaceuticals Corp. (I) 5,180 75,214 Connetics Corp. (I) 5,000 108,650 ICOS Corp. (I)(L) 5,000 112,800 IVAX Corp. (I) 13,350 252,315 Medicines Co. (The) (I) 15,000 320,250 MGI Pharma, Inc. (I)(L) 8,000 176,400 Nuvelo, Inc. (I) 33,000 192,390 Pharmion Corp. (I) 5,000 115,500 Rigel Pharmaceuticals, Inc. (I) 15,000 257,250 Salix Pharmaceuticals, Ltd. (I) 7,000 100,100 Shire Pharmaceuticals Group Plc, American Depositary Receipt (ADR) (United Kingdom) 6,000 186,480 Teva Pharmaceutical Industries Ltd. (ADR) (Israel) 9,000 281,160 Interest Par value Issuer, description, maturity date rate (000) Value - ------------------------------------------------------------------------------ Short-term investments 15.54% $2,491,312 - ------------------------------------------------------------------------------ (Cost $2,491,312) Joint Repurchase Agreement 6.03% 966,000 - ------------------------------------------------------------------------------ Investment in a joint repurchase agreement transaction with Bank of America Corp. - Dated 4-29-05 due 5-2-05 (secured by U.S. Treasury STRIPS due 11-15-10 thru 8-15-25) 2.85% $966 966,000 Shares - ------------------------------------------------------------------------------ Cash Equivalents 9.51% 1,525,312 - ------------------------------------------------------------------------------ AIM Cash Investment Trust (T) 1,525,312 1,525,312 - ------------------------------------------------------------------------------ Total investments 110.09% $17,652,700 - ------------------------------------------------------------------------------ Other assets and liabilities, net (10.09%) ($1,617,527) - ------------------------------------------------------------------------------ Total net assets 100.00% $16,035,173 - ------------------------------------------------------------------------------ John Hancock Biotechnology Fund Footnotes to Schedule of Investments (I) Non-income-producing security. (L) All or a portion of this security is on loan as of April 30, 2005. (T) Represents investment of securities lending collateral. Parenthetical disclosure of a foreign country in the security description represents country of a foreign issuer. The percentage shown for each investment category is the total value of that category as a percentage of the net assets of the Fund. John Hancock Biotechnology Fund ASSETS AND LIABILITIES April 30, 2005 (unaudited) Assets Investments, at value (cost $16,104,513) including $1,495,404 of securities loaned $17,652,700 Cash 247 Receivable for shares sold 3,674 Interest receivable 153 Receivable from affiliates 14,770 Other assets 732 Total assets 17,672,276 Liabilities Payable for shares repurchased 72,574 Payable upon return of securites loaned 1,525,312 Payable to affiliates Management fees 12,197 Distribution and service fees 1,385 Other 7,662 Other payables and accrued expenses 17,973 Total liabilities 1,637,103 Net assets Capital paid-in 19,045,519 Accumulated net realized loss on investments (4,374,739) Net unrealized appreciation of investments 1,548,187 Accumulated net investment loss (183,794) Net assets $16,035,173 Net asset value per share Based on net asset values and shares outstanding -- the Fund has an unlimited number of shares authorized with no par value Class A ($6,463,263/851,094 shares) $7.59 Class B ($6,926,016/938,172 shares) $7.38 Class C ($2,645,894/358,411 shares) $7.38 Maximum offering price per share Class A 1 (7.59/95%) $7.99 1 On single retail sales of less than $50,000. On sales of $50,000 or more and on group sales the offering price is reduced. See notes to financial statements. John Hancock Biotechnology Fund OPERATIONS For the period ended April 30, 2005 (unaudited) 1 Investment income Interest $5,386 Securities lending 3,681 Dividends (net of foreign withholding taxes of $425) 3,566 Total investment income 12,633 Expenses Investment management fees 87,674 Class A distribution and service fees 11,867 Class B distribution and service fees 39,836 Class C distribution and service fees 18,023 Transfer agent fees 47,216 Registration and filing fees 19,439 Printing 13,092 Professional fees 11,071 Custodian fees 7,460 Miscellaneous 3,420 Accounting and legal services fees 2,375 Trustees' fees 358 Securities lending fees 176 Total expenses 262,007 Less expense reductions (65,640) Net expenses 196,367 Net investment loss (183,734) REALIZED AND UNREALIZED GAIN (LOSS) Net realized gain on investments 584,476 Change in net unrealized appreciation (depreciation) of Investments (982,902) Net realized and unrealized loss (398,426) Decrease in net assets from operations ($582,160) 1 Semiannual period from 11-1-04 through 4-30-05. See notes to financial statements. John Hancock Biotechnology Fund CHANGES IN NET ASSETS Year ended Period ended 10-31-04 4-30-05 1 Increase (decrease) in net assets From operations Net investment loss ($429,387) ($183,734) Net realized gain 2,324,411 584,476 Change in net unrealized appreciation (depreciation) (932,719) (982,902) Increase (decrease) in net assets resulting from operations 962,305 (582,160) From Fund share transactions 904,366 (4,152,725) Net assets Beginning of period 18,903,387 20,770,058 End of period 2 $20,770,058 $16,035,173 1 Semiannual period from 11-1-04 through 4-30-05. Unaudited. 2 Includes accumulated net investment loss of $60 and $183,794, respectively. See notes to financial statements. John Hancock Biotechnology Fund Financial Highlights CLASS A Period ended 10-31-01 1 10-31-02 10-31-03 10-31-04 4-30-05 2 Per share operating performance Net asset value, beginning of period $10.00 $9.49 $5.55 $7.39 $7.86 Net investment loss 3 (0.07) (0.09) (0.08) (0.12) (0.06) Net realized and unrealized gain (loss) on investments (0.44) (3.84) 1.92 0.59 (0.21) Total from investment operations (0.51) (3.93) 1.84 0.47 (0.27) Less distributions From net investment income -- (0.01) -- -- -- Net asset value, end of period $9.49 $5.55 $7.39 $7.86 $7.59 Total return 4,5 (%) (5.10) 6 (41.46) 33.15 6.36 (3.44) 6 Ratios and supplemental data Net assets, end of period (in millions) $6 $5 $8 $8 $6 Ratio of expenses to average net assets (%) 1.60 7 1.60 1.60 1.60 1.60 7 Ratio of adjusted expenses to average net assets 8 (%) 4.34 7 2.59 2.65 2.12 2.27 7 Ratio of net investment loss to average net assets (%) (1.15) 7 (1.29) (1.35) (1.46) (1.47) 7 Portfolio turnover (%) 63 97 130 80 17 See notes to financial statements. John Hancock Biotechnology Fund Financial Highlights CLASS B Period ended 10-31-01 1 10-31-02 10-31-03 10-31-04 4-30-05 2 Per share operating performance Net asset value, beginning of period $10.00 $9.44 $5.49 $7.26 $7.67 Net investment loss 3 (0.13) (0.14) (0.13) (0.17) (0.09) Net realized and unrealized gain (loss) on investments (0.43) (3.81) 1.90 0.58 (0.20) Total from investment operations (0.56) (3.95) 1.77 0.41 (0.29) Net asset value, end of period $9.44 $5.49 $7.26 $7.67 $7.38 Total return 4,5 (%) (5.60) 6 (41.84) 32.24 5.65 (3.78) 6 Ratios and supplemental data Net assets, end of period (in millions) $4 $4 $8 $9 $7 Ratio of expenses to average net assets (%) 2.30 7 2.30 2.30 2.30 2.30 7 Ratio of adjusted expenses to average net assets 8 (%) 5.05 7 3.29 3.35 2.82 2.97 7 Ratio of net investment loss to average net assets (%) (2.01) 7 (1.99) (2.05) (2.16) (2.17) 7 Portfolio turnover (%) 63 97 130 80 17 See notes to financial statements. John Hancock Biotechnology Fund Financial Highlights CLASS C Period ended 10-31-01 1 10-31-02 10-31-03 10-31-04 4-30-05 2 Per share operating performance Net asset value, beginning of period $10.00 $9.44 $5.49 $7.26 $7.67 Net investment loss 3 (0.13) (0.14) (0.13) (0.17) (0.09) Net realized and unrealized gain (loss) on investments (0.43) (3.81) 1.90 0.58 (0.20) Total from investment operations (0.56) (3.95) 1.77 0.41 (0.29) Net asset value, end of period $9.44 $5.49 $7.26 $7.67 $7.38 Total return 4,5 (%) (5.60) 6 (41.84) 32.24 5.65 (3.78) 6 Ratios and supplemental data Net assets, end of period (in millions) $2 $2 $2 $4 $3 Ratio of expenses to average net assets (%) 2.30 7 2.30 2.30 2.30 2.30 7 Ratio of adjusted expenses to average net assets 8 (%) 5.05 7 3.29 3.35 2.82 2.97 7 Ratio of net investment loss to average net assets (%) (2.07) 7 (1.99) (2.05) (2.16) (2.17) 7 Portfolio turnover (%) 63 97 130 80 17 1 Class A, Class B and Class C shares began operations on 3-1-01. 2 Semiannual period from 11-1-04 through 4-30-05. Unaudited. 3 Based on the average of the shares outstanding. 4 Assumes dividend reinvestment and does not reflect the effect of sales charges. 5 Total returns would have been lower had certain expenses not been reduced during the periods shown. 6 Not annualized. 7 Annualized. 8 Does not take into consideration expense reductions during the periods shown. See notes to financial statements. NOTES TO FINANCIAL STATEMENTS (unaudited) Note A Accounting policies John Hancock Biotechnology Fund (the "Fund") is a non-diversified series of John Hancock World Fund, an open-end management investment company registered under the Investment Company Act of 1940. The investment objective of the Fund is to achieve long-term capital appreciation. The Trustees have authorized the issuance of multiple classes of shares of the Fund, designated as Class A, Class B and Class C shares. The shares of each class represent an interest in the same portfolio of investments of the Fund and have equal rights as to voting, redemptions, dividends and liquidation, except that certain expenses, subject to the approval of the Trustees, may be applied differently to each class of shares in accordance with current regulations of the Securities and Exchange Commission and the Internal Revenue Service. Shareholders of a class that bears distribution and service expenses under the terms of a distribution plan have exclusive voting rights to that distribution plan. Significant accounting policies of the Fund are as follows: Valuation of investments Securities in the Fund's portfolio are valued on the basis of market quotations, valuations provided by independent pricing services or at fair value as determined in good faith in accordance with procedures approved by the Trustees. Short-term debt investments which have a remaining maturity of 60 days or less may be valued at amortized cost, which approximates market value. Investments in AIM Cash Investment Trust are valued at their net asset value each business day. Joint repurchase agreement Pursuant to an exemptive order issued by the Securities and Exchange Commission, the Fund, along with other registered investment companies having a management contract with John Hancock Advisers, LLC (the "Adviser"), a wholly owned subsidiary of John Hancock Financial Services, Inc., may participate in a joint repurchase agreement transaction. Aggregate cash balances are invested in one or more large repurchase agreements, whose underlying securities are obligations of the U.S. government and/or its agencies. The Fund's custodian bank receives delivery of the underlying securities for the joint account on the Fund's behalf. The Adviser is responsible for ensuring that the agreement is fully collateralized at all times. Investment transactions Investment transactions are recorded as of the date of purchase, sale or maturity. Net realized gains and losses on sales of investments are determined on the identified cost basis. Class allocations Income, common expenses and realized and unrealized gains (losses) are determined at the fund level and allocated daily to each class of shares based on the appropriate net asset value of the respective classes. Distribution and service fees, if any, are calculated daily at the class level based on the appropriate net asset value of each class and the specific expense rate(s) applicable to each class. Expenses The majority of expenses are directly identifiable to an individual fund. Expenses that are not readily identifiable to a specific fund are allocated in such a manner as deemed equitable, taking into consideration, among other things, the nature and type of expense and the relative sizes of the funds. Bank borrowings The Fund is permitted to have bank borrowings for temporary or emergency purposes, including the meeting of redemption requests that otherwise might require the untimely disposition of securities. The Fund has entered into a syndicated line of credit agreement with various banks. This agreement enables the Fund to participate, with other funds managed by the Adviser, in an unsecured line of credit with banks, which permits borrowings of up to $250 million, collectively. Interest is charged to each fund based on its borrowing. In addition, a commitment fee is charged to each fund based on the average daily unused portion of the line of credit, and is allocated among the participating funds. The Fund had no borrowing activity under the line of credit during the period ended April 30, 2005. Securities lending The Fund may lend securities to certain qualified brokers who pay the Fund negotiated lender fees. The loans are collateralized at all times with cash or securities with a market value at least equal to the market value of the securities on loan. As with other extensions of credit, the Fund may bear the risk of delay of the loaned securities in recovery or even loss of rights in the collateral, should the borrower of the securities fail financially. On April 30, 2005, the Fund loaned securities having a market value of $1,495,404 collateralized by cash in the amount of $1,525,312. The cash collateral was invested in a short-term instrument. Securities lending expenses are paid by the Fund to the Adviser. Federal income taxes The Fund qualifies as a "regulated investment company" by complying with the applicable provisions of the Internal Revenue Code and will not be subject to federal income tax on taxable income that is distributed to shareholders. Therefore, no federal income tax provision is required. For federal income tax purposes, the Fund has $4,431,628 of a capital loss carryforward available, to the extent provided by regulations, to offset future net realized capital gains. To the extent that such carryforward is used by the Fund, no capital gain distributions will be made. The loss carryforward expires as follows: October 31, 2010 - $3,046,491 and October 31, 2011 - $1,385,137. Dividends, interest and distributions Dividend income on investment securities is recorded on the ex-dividend date or, in the case of some foreign securities, on the date thereafter when the Fund identifies the dividend. Interest income on investment securities is recorded on the accrual basis. Foreign income may be subject to foreign withholding taxes, which are accrued as applicable. The Fund records distributions to shareholders from net investment income and net realized gains, if any, on the ex-dividend date. Distributions paid by the Fund with respect to each class of shares are calculated in the same manner, at the same time and are in the same amount, except for the effect of expenses that may be applied differently to each class. Such distributions, on a tax basis, are determined in conformity with income tax regulations, which may differ from accounting principles generally accepted in the United States of America. Distributions in excess of tax basis earnings and profits, if any, are reported in the Fund's financial statements as a return of capital. Use of estimates The preparation of these financial statements, in accordance with accounting principles generally accepted in the United States of America, incorporates estimates made by management in determining the reported amount of assets, liabilities, revenues and expenses of the Fund. Actual results could differ from these estimates. Note B Management fee and transactions with affiliates and others The Fund has an investment management contract with the Adviser. Under the investment management contract, the Fund pays a monthly management fee to the Adviser equivalent, on an annual basis, to the sum of: (a) 0.90% of the first $500,000,000 of the Fund's average daily net asset value, (b) 0.85% of the next $500,000,000 and (c) 0.80% of the Fund's average daily net asset value in excess of $1,000,000,000. The Adviser has agreed to limit the Fund's total expenses excluding the distribution and service fees, to 1.30% of the Fund's average daily net asset value, at least until February 28, 2006. Accordingly, the expense reduction related to the total expense limitation amounted to $65,640 for the period ended April 30, 2005. The Adviser reserves the right to terminate this limitation in the future. The Fund has Distribution Plans with John Hancock Funds, LLC ("JH Funds"), a wholly owned subsidiary of the Adviser. The Fund has adopted Distribution Plans with respect to Class A, Class B and Class C, pursuant to Rule 12b-1 under the Investment Company Act of 1940, to reimburse JH Funds for the services it provides as distributor of shares of the Fund. Accordingly, the Fund makes monthly payments to JH Funds at an annual rate not to exceed 0.30% of Class A average daily net asset value and 1.00% of Class B and Class C average daily net asset value. A maximum of 0.25% of such payments may be service fees, as defined by the Conduct Rules of the National Association of Securities Dealers. Under the Conduct Rules, curtailment of a portion of the Fund's 12b-1 payments could occur under certain circumstances. Class A shares are assessed up-front sales charges. During the period ended April 30, 2005, JH Funds received net up-front sales charges of $15,537 with regard to sales of Class A shares. Of this amount, $2,563 was retained and used for printing prospectuses, advertising, sales literature and other purposes, $11,652 was paid as sales commissions to unrelated broker-dealers and $1,322 was paid as sales commissions to sales personnel of Signator Investors, Inc. ("Signator Investors"), a related broker-dealer. The Adviser's indirect parent, John Hancock Life Insurance Company ("JHLICo."), is the indirect sole shareholder of Signator Investors. Class B shares that are redeemed within six years of purchase are subject to a contingent deferred sales charge ("CDSC") at declining rates, beginning at 5.00% of the lesser of the current market value at the time of redemption or the original purchase cost of the shares being redeemed. Class C shares that are redeemed within one year of purchase are subject to a CDSC at a rate of 1.00% of the lesser of the current market value at the time of redemption or the original purchase cost of the shares being redeemed. Proceeds from the CDSCs are paid to JH Funds and are used, in whole or in part, to defray its expenses for providing distribution-related services to the Fund in connection with the sale of Class B and Class C shares. During the period ended April 30, 2005, CDSCs received by JH Funds amounted to $26,944 for Class B shares and $1,044 for Class C shares. The Fund has a transfer agent agreement with John Hancock Signature Services, Inc. ("Signature Services"), an indirect subsidiary of JHLICo. For Class A, Class B and Class C shares, the Fund pays a monthly transfer agent fee at an annual rate of 0.05% of the Fund's average daily net asset value, plus a fee based on the number of shareholder accounts and reimbursement for certain out-of-pocket expenses, aggregated and allocated to each class on the basis of its relative net asset value. Signature Services agreed to voluntarily reduce the Fund's asset-based portion of the transfer agent fee if the total transfer agent fee exceeds the Lipper, Inc. median transfer agency fee for comparable mutual funds by 0.05%. There were no transfer agent fee reductions during the period ended April 30, 2005. Signature Services reserves the right to terminate this limitation at any time. The Fund has an agreement with the Adviser to perform necessary tax, accounting and legal services for the Fund. The compensation for the period amounted to $2,375. The Fund also paid the Adviser the amount of $49 for certain publishing services, included in the printing fees. Mr. James A. Shepherdson is a director and officer of the Adviser, as well as affiliated Trustee of the Fund, and is compensated by the Adviser. The compensation of unaffiliated Trustees is borne by the Fund. The unaffiliated Trustees may elect to defer, for tax purposes, their receipt of this compensation under the John Hancock Group of Funds Deferred Compensation Plan. The Fund makes investments into other John Hancock funds, as applicable, to cover its liability for the deferred compensation. Investments to cover the Fund's deferred compensation liability are recorded on the Fund's books as an other asset. The deferred compensation liability and the related other asset are always equal and are marked to market on a periodic basis to reflect any income earned by the investments, as well as any unrealized gains or losses. The Deferred Compensation Plan investments had no impact on the operations of the Fund. Note C Fund share transactions This listing illustrates the number of Fund shares sold and repurchased during the last two periods, along with the corresponding dollar value. YEAR ENDED 10-31-04 PERIOD ENDED 4-30-05 1 SHARES AMOUNT SHARES AMOUNT CLASS A SHARES Sold 995,092 $8,365,725 166,711 $1,376,808 Repurchased (1,047,383) (8,849,637) (362,303) (2,901,646) Net decrease (52,291) ($483,912) (195,592) ($1,524,838) CLASS B SHARES Sold 588,836 $4,817,701 63,309 $496,875 Repurchased (585,849) (4,633,982) (272,688) (2,152,947) Net increase (decrease) 2,987 $183,719 (209,379) ($1,656,072) CLASS C SHARES Sold 248,261 $1,998,289 28,720 $229,792 Repurchased (100,421) (793,730) (158,549) (1,201,607) Net increase (decrease) 147,840 $1,204,559 (129,829) ($971,815) NET INCREASE (DECREASE) 98,536 $904,366 (534,800) ($4,152,725) 1 Semiannual period from 11-1-04 through 4-30-05. Unaudited. Note D Investment transactions Purchases and proceeds from sales or maturities of securities, other than short-term securities and obligations of the U.S. government, during the period ended April 30, 2005, aggregated $3,173,689 and $7,390,118, respectively. The cost of investments owned on April 30, 2005, including short-term investments, for federal income tax purposes, was $16,532,710. Gross unrealized appreciation and depreciation of investments aggregated $2,516,445 and $1,396,455, respectively, resulting in net unrealized appreciation of $1,119,990. The difference between book basis and tax basis net unrealized appreciation of investments is attributable primarily to the tax deferral of losses on certain sales of securities. Note E Proposed reorganization On March 8, 2005, the Trustees approved the reorganization of John Hancock Biotechnology Fund into John Hancock Health Sciences Fund. The reorganization is scheduled to take place after the close of business on June 10, 2005, subject to approval by shareholders at a special shareholder meeting. Note F Shareholder meeting On December 1, 2004, a Special Meeting of shareholders of the Fund was held to elect nine Trustees effective January 1, 2005. Proxies covering 2,215,366 shares of beneficial interest were voted at the meeting. The shareholders elected the following Trustees to serve until their respective successors are duly elected and qualified, with the votes tabulated as follows: WITHHELD FOR AUTHORITY - --------------------------------------------------------------- James F. Carlin 2,192,119 23,247 Richard P. Chapman, Jr. 2,191,985 23,381 William H. Cunningham 2,192,119 23,247 Ronald R. Dion 2,196,118 19,248 Charles L. Ladner 2,195,426 19,940 Dr. John A. Moore 2,191,985 23,381 Patti McGill Peterson 2,196,118 19,248 Steven R. Pruchansky 2,195,560 19,806 James A. Shepherdson 2,195,560 19,806 John Hancock Biotechnology Fund Trustees James F. Carlin Richard P. Chapman, Jr.* William Cunningham Ronald Dion Charles L. Ladner* Dr. John A. Moore* Patti McGill Peterson* Steven R. Pruchansky Lt. Gen. Norman H. Smith, USMC (Ret.) * Member of Audit Committee Officers James A. Shepherdson President and Chief Executive Officer William H. King Vice President and Treasurer Investment Adviser John Hancock Advisers, LLC 101 Huntington Avenue Boston, MA 02199-7603 Principal Distributor John Hancock Funds, LLC 101 Huntington Avenue Boston, MA 02199-7603 Custodian The Bank of New York One Wall Street New York, NY 10286 Transfer Agent John Hancock Signature Services, Inc. 1 John Hancock Way, Suite 1000 Boston, MA 02217-1000 Legal Counsel Wilmer Cutler Pickering Hale and Dorr LLP 60 State Street Boston, MA 02109-1803 JOHN HANCOCK Health Sciences Fund 4.30.2005 Semiannual Report [A 2" x 1" John Hancock (Signature)/John Hancock Funds logo in lower, center middle of page. A tag line below reads "JOHN HANCOCK FUNDS."] [A photo of James A. Shepherdson, Chief Executive Officer, flush left next to first paragraph.] CEO CORNER Table of contents Your fund at a glance page 1 Managers' report page 2 A look at performance page 6 Growth of $10,000 page 7 Your expenses page 8 Fund's investments page 10 Financial statements page 14 For more information page 29 Dear Fellow Shareholders, After advancing for a second straight year in 2004, the stock market pulled back in the first four months of 2005. For much of 2004 the market had been in the doldrums as investors fretted about rising oil prices, higher interest rates, the war in Iraq and a closely contested presidential race. But the year ended on a high note with a sharp rally sparked by a definitive end to the U.S. presidential election and moderating oil prices. Investors were brought back down to earth in January, however, as the market declined in three of the four weeks and produced negative results for the month in a broad-based move downward. Rising oil prices and interest rates, and concerns about less robust corporate earnings growth were among the culprits that kept investors on the sidelines. Investors began to re-enter the market in February, reversing January's decline. But as the month progressed into March and April investors again grew concerned about further spikes in oil prices and rising interest rates. As a result, the first four months of 2005 ended with the major indexes in the red. By the end of April, the Dow Jones Industrial Average had returned -4.81%, the S&P 500 Index returned -4.00%, while the Nasdaq Composite Index fell by 11.67%. Bonds performed slightly better, managing to produce positive results, with the Lehman Brothers Aggregate Bond Index returning 0.87%. In October, you may recall we requested your vote on a proposal regarding the election of your fund's Board of Trustees. We are pleased to report that shareholders overwhelmingly approved the proposal, which became effective January 1, 2005. As a result, all open-end John Hancock funds now have the same Board of Trustees, comprised of ten members -- nine of them, including the Chairman, are independent Trustees with no direct or indirect interest in John Hancock Advisers, LLC, your fund's investment adviser. We believe this move is a way to improve the effectiveness of the Trustees' oversight of the funds, and we are grateful for your support. Sincerely, /S/ JAMES A. SHEPHERDSON James A. Shepherdson, Chief Executive Officer This commentary reflects the CEO's views as of April 30, 2005. They are subject to change at any time. YOUR FUND AT A GLANCE The Fund seeks long-term growth of capital by normally investing at least 80% of its assets in stocks of U.S. and foreign health sciences companies. Over the last six months * The stock market posted modest returns in the face of rising interest rates and oil prices. * Health care stocks outperformed the broad market, as they are typically viewed as a defensive move amid uncertainty. * Underweightings in large pharmaceuticals, and good stock choices among managed care and pharmacy benefit managers, boosted the Fund's results. [Bar chart with heading "John Hancock Health Sciences Fund." Under the heading is a note that reads "Fund performance for the six months ended April 30, 2005." The chart is scaled in increments of 5% with 0% at the bottom and 10% at the top. The first bar represents the 7.74% total return for Class A. The second bar represents the 7.36% total return for Class B. The third bar represents the 7.36% total return for Class C. A note below the chart reads "Total returns for the Fund are at net asset value with all distributions reinvested. These returns do not reflect the deduction of the maximum sales charge, which would reduce the performance shown above."] Top 10 holdings 5.0% Medtronic, Inc. 4.2% Abbot Laboratories 3.7% Genentech, Inc. 3.6% Amgen, Inc. 3.2% UnitedHealth Group, Inc. 3.2% Hospira, Inc. 3.1% Johnson & Johnson 2.9% WellPoint, Inc. 2.7% Caremark Rx, Inc. 2.7% Novartis AG As a percentage of net assets on April 30, 2005. 1 BY ROBERT C. JUNKIN, CPA, PORTFOLIO MANAGER MANAGER'S REPORT JOHN HANCOCK Health Sciences Fund Robert Junkin recently assumed the management of John Hancock Health Sciences Fund, replacing Linda J. Miller who left the company to pursue other interests. Recently, John Hancock Biotechnology Fund merged into John Hancock Health Sciences Fund upon receiving approval from shareholders. Despite some noteworthy regulatory and legal headwinds, health care stocks outpaced the broader stock market for the six months ended April 30, 2005. During November and early December 2004, the group staged a significant post-presidential-election relief rally, fueled by investors' optimism that the re-election of President Bush would preclude more industry regulation, increases in competition from overseas drug makers, price curbs and other less favorable changes. However, the performance of the various subsectors that make up the health care group began to diverge in the first four months of 2005. In the wake of concerns over potentially slowing economic conditions and rising inflation, the group's historic reputation as being defensive helped attract investor demand, pushing the stock prices for many health care companies -- including HMOs, hospitals and even battered drug stocks. In contrast, the more speculative areas -- namely biotech -- suffered as investors increasingly shunned riskier assets. "Despite some noteworthy regu- latory and legal headwinds, health care stocks outpaced the broader stock market for the six months ended April 30, 2005." Performance For the six months ended April 30, 2005, John Hancock Health Sciences Fund's Class A, Class B and Class C shares posted total returns of 7.74%, 7.36% and 7.36%, respectively, at net asset value. During the same six-month period, the Russell 3000 Healthcare Index returned 10.77% and the average health/biotechnology fund had a total return of 5.98%, according to Lipper, Inc.,1 while the Standard & Poor's 500 Index returned 3.28%. Keep in mind that your net asset value return will be different from the Fund's performance if you were not invested in the Fund for the entire 2 period and did not reinvest all distributions. See pages six and seven for historical performance results. [A photo of Robert Junkin, flush right next to first paragraph.] We believe that our underperformance of the index was due to our overweighting in biotech concerns. We attribute our outperformance of the Lipper average to our lower exposure to large drug companies. Managed care, PBMs top the Fund's winners list At the top of our best-performers list during the period were a number of managed care and pharmacy benefit managers (PBMs), the latter of which design prescription plans and process pharmacy data claims for their customers, who include businesses, health plans and government employers that provide drug coverage for employees. Managed care companies have benefited from rising earnings which resulted from health care premium increases they passed onto their customers and that were compounded by moderating medical cost trends. For example, the stock price of WellPoint, Inc., the nation's largest health insurance provider, surged as it continued to post strong profit and earnings growth following its November 2004 merger with Anthem. Similarly, UnitedHealth Group Inc. also performed well, benefiting from significant profit increases across its business units. Pharmacy benefit manager Caremark Rx was another winner. Much of Caremark's bottom-line growth resulted from the strength of its mail-order pharmacy and from the company's recent acquisition of rival AdvancePCS. Another PBM, Medco Health Solutions, also benefited from strong volume growth from its mail-order prescription business. "At the top of our best-performers list during the period were a number of managed care and pharmacy benefit managers..." Another factor aiding the Fund's performance was our decision to maintain an underweighting relative to the benchmark in large-cap pharmaceutical companies, because as a group, they lagged the overall health care sector, battered by concerns over weak new product pipelines, patent expirations and negative product news. Biotech holdings mixed Because growing concerns about slowing economic conditions put pressure on the more speculative segments of the stock market, our overweighting in biotech stocks proved to be the biggest detractor 3 from performance during the period. That said, our stock selection within the group was generally favorable and we held a number of winners during the period. One of the Fund's best performers overall was Genentech, the world's biggest biotech company. It reported strong growth in profits and revenues as its sales of its new cancer drug Avastin continued to expand. Avastin, a new drug that fights tumors by cutting off their blood supply has quickly become Genentech's most successful product since it was approved in 2004 and is one of the fastest-growing cancer drugs ever. The company's stock continued to surge after it was announced in mid-April that Avastin helped some of the sickest breast cancer patients live longer than expected. Shareholders also cheered the late-period news that the drug Herceptin, an older cancer therapy from Genentech, helped prevent the recurrence of breast cancer following tumor surgery. In the biotechnology diagnostic area, we saw strong gains from our holdings in Gen-Probe, as it posted solid earnings growth. [Table at top left-hand side of page entitled "Industry distribution 2." The first listing is Health care equipment - 25%, the second is Pharmaceuticals - 23%, the third is Biotechnology - 21%, the fourth is Health care services - 11%, the fifth is Managed health care - 7%, the sixth is Health care facilities - 4%, the seventh is Health care supplies - 2% and the eighth is Health care distributors - 1%.] [Pie chart just below middle of page with heading "Portfolio diversification 2." The chart is divided into two sections (from top to right): Common stocks 94% and Short-term investments & other 6%. ] Unfortunately, there were also a number of disappointments among our biotech holdings. The biggest one was Biogen Idec, which suffered losses in response to news that the company was suspending sales of Tysabri following the death of several multiple sclerosis patients who were taking the drug and contracted a rare neurological disease. Boston Scientific also disappointed, primarily due to concerns that it could lose sales of its cardiovascular stent to rival Johnson & Johnson. We also lost ground with AtheroGenics, which is focused on the treatment of chronic inflammatory diseases. It suffered from concerns over the veracity of the data it published regarding the efficacy of its cholesterol treatment. 4 [Table at top of page entitled "Scorecard." The header for the left column is "Investment" and the header for the right column is "Period's performanceand what's behind the numbers." The first listing is WellPoint Inc. followed by an up arrow with the phrase "Premium increases + moderating costs = earnings gains." The second listing is Genentech followed by an up arrow with the phrase "Investors cheer positive news on company's cancer drugs." The third listing is Biogen Idec followed by a down arrow with the phrase "Suspension of sales of MS drug hurts stock."] Outlook In our view, health care stocks may continue to be subject to the risks of increased regulatory and legal scrutiny throughout 2005, although we remain quite optimistic about them over the long term. Continued government scrutiny of product marketing and manufacturing, Medicare and physician billing practices, consolidation activities and corporate transparency all may continue to grab headlines and increase health care companies' cost of doing business. Furthermore, the newly enacted federal drug benefits program is likely to affect some health care subgroups more negatively than others. Potentially offsetting these challenges are higher interest rates and a slowing global economy, which could continue to prompt more investors to gravitate toward defensive segments of the stock market, including health care securities. But we believe that over the longer term, the prospects for health care stocks are quite good, because demographics and product innovation continue to be favorable for the industry. No matter what the environment, we'll continue to work to uncover companies with exciting new product and service developments whose stocks are selling at compelling valuations. "...health care stocks may continue to be subject to the risks of increased regulatory and legal scrutiny throughout 2005, although we remain quite optimistic about them over the long term." This commentary reflects the views of the portfolio manager through the end of the Fund's period discussed in this report. The manager's statements reflect his own opinions. As such, they are in no way guarantees of future events, and are not intended to be used as investment advice or a recommendation regarding any specific security. They are also subject to change at any time as market and other conditions warrant. Sector investing is subject to greater risks than the market as a whole. 1 Figures from Lipper, Inc. include reinvested dividends and do not take into account sales charges. Actual load-adjusted performance is lower. 2 As a percentage of net assets on 4-30-05. 5 A LOOK AT PERFORMANCE For the period ended April 30, 2005 Class A Class B Class C Inception date 10-1-91 3-7-94 3-1-99 Average annual returns with maximum sales charge (POP) One year -4.93% -5.41% -1.59% Five years 3.42 3.41 3.75 Ten years 10.49 10.43 -- Since inception -- -- 5.16 Cumulative total returns with maximum sales charge (POP) Six months 2.36 2.36 6.36 One year -4.93 -5.41 -1.59 Five years 18.32 18.23 20.23 Ten years 171.10 169.64 -- Since inception -- -- 36.39 Performance figures assume all distributions are reinvested. Returns with maximum sales charge reflect a sales charge on Class A shares of 5%, and the applicable contingent deferred sales charge (CDSC) on Class B and Class C shares. The returns for Class C shares have been adjusted to reflect the elimination of the front-end sales charge effective July 15, 2004. The Class B shares' CDSC declines annually between years 1-6 according to the following schedule: 5, 4, 3, 3, 2, 1%. No sales charge will be assessed after the sixth year. Class C shares held for less than one year are subject to a 1% CDSC. The returns reflect past results and should not be considered indicative of future performance. The return and principal value of an investment will fluctuate so that shares, when redeemed, may be worth more or less than their original cost. Due to market volatility, the Fund's current performance may be higher or lower than the performance shown. For performance data current to the most recent month-end, please call 1-800-225-5291 or visit the Fund's Web site at www.jhfunds.com. The performance table above and the chart on the next page do not reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. The Fund's performance results reflect any applicable expense reductions, without which the expenses would increase and results would have been less favorable. 6 GROWTH OF $10,000 This chart shows what happened to a hypothetical $10,000 investment in Class A shares for the period indicated. For comparison, we've shown the same investment in two separate indexes. [Line chart with the heading "GROWTH OF $10,000." Within the chart are four lines. The first line represents the Russell 3000 Healthcare Index and is equal to $33,708 as of April 30, 2005. The second line represents the value of the hypothetical $10,000 investment made in the John Hancock Health Sciences Fund, before sales charge, and is equal to $28,543 as of April 30, 2005. The third line represents the value of the same hypothetical investment made in the John Hancock Health Sciences Fund, after sales charge, and is equal to $27,110 as of April 30, 2005. The fourth line represents the Standard & Poor's 500 Index and is equal to $26,562 as of April 30, 2005.] Class B 1 Class C 1 Period beginning 4-30-95 3-1-99 Health Sciences Fund $26,964 $13,639 Index 1 26,562 10,265 Index 2 33,708 11,258 Assuming all distributions were reinvested for the period indicated, the table above shows the value of a $10,000 investment in the Fund's Class B and Class C shares, respectively, as of April 30, 2005. The Class C shares investment with maximum sales charge has been adjusted to reflect the elimination of the front-end sales charge effective July 15, 2004. Performance of the classes will vary based on the difference in sales charges paid by shareholders investing in the different classes and the fee structure of those classes. Standard & Poor's 500 Index -- Index 1 -- is an unmanaged index that includes 500 widely traded common stocks. Russell 3000 Healthcare Index -- Index 2 -- is a capitalization-weighted index composed of companies involved in medical services or health care. It is not possible to invest directly in an index. Index figures do not reflect sales charges and would be lower if they did. 1 No contingent deferred sales charge applicable. 7 YOUR EXPENSES These examples are intended to help you understand your ongoing operating expenses. Understanding fund expenses As a shareholder of the Fund, you incur two types of costs: * Transaction costs which include sales charges (loads) on purchases or redemptions (varies by share class), minimum account fee charge, etc. * Ongoing operating expenses including management fees, distribution and service fees (if applicable) and other fund expenses. We are going to present only your ongoing operating expenses here. Actual expenses/actual returns This example is intended to provide information about your fund's actual ongoing operating expenses, and is based on your fund's actual return. It assumes an account value of $1,000.00 on October 31, 2004, with the same investment held until April 30, 2005. Account value Expenses paid $1,000.00 Ending value during period on 10-31-04 on 4-30-05 ended 4-30-05 1 Class A $1,077.40 $8.24 Class B 1,073.60 11.82 Class C 1,073.60 11.82 Together with the value of your account, you may use this information to estimate the operating expenses that you paid over the period. Simply divide your account value at April 30, 2005 by $1,000.00, then multiply it by the "expenses paid" for your share class from the table above. For example, for an account value of $8,600.00, the operating expenses should be calculated as follows: Example -- -- -- -- | My account value / | | "expenses paid" | My | / $1,000.00 = 8.6 | X $| | = actual | $8,600.00 / | | from table | expenses -- -- -- -- 8 Hypothetical example for comparison purposes This table allows you to compare your fund's ongoing operating expenses with those of any other fund. It provides an example of the Fund's hypothetical account values and hypothetical expenses based on each class's actual expense ratio and an assumed 5% annual return before expenses (which is not your fund's actual return). It assumes an account value of $1,000.00 on October 31, 2004, with the same investment held until April 30, 2005. Look in any other fund shareholder report to find its hypothetical example and you will be able to compare these expenses. Account value Expenses paid $1,000.00 Ending value during period on 10-31-04 on 4-30-05 ended 4-30-05 1 Class A $1,016.86 $8.00 Class B 1,013.39 11.48 Class C 1,013.39 11.48 Remember, these examples do not include any transaction costs, such as sales charges; therefore, these examples will not help you to determine the relative total costs of owning different funds. If transaction costs were included, your expenses would have been higher. See the prospectus for details regarding transaction costs. 1 Expenses are equal to the Fund's annualized expense ratio of 1.60%, 2.30% and 2.30% for Class A, Class B and Class C, respectively, multiplied by the average account value over the period, multiplied by number of days in most recent fiscal half-year/365 or 366 (to reflect the one-half year period). 9 FINANCIAL STATEMENTS FUND'S INVESTMENTS Securities owned by the Fund on April 30, 2005 (unaudited) This schedule is divided into two main categories: common stocks and short-term investments. Common stocks are further broken down by industry group. Short-term investments, which represent the Fund's cash position, are listed last. Issuer Shares Value Common stocks 94.04% $250,440,693 (Cost $176,629,980) Biotechnology 20.84% 55,487,302 Amgen, Inc. (I) 162,800 9,476,588 Celgene Corp. (I)(L) 110,000 4,170,100 Charles River Laboratories International, Inc. (I) 57,000 2,700,090 Eyetech Pharmaceuticals, Inc. (I)(L) 100,000 2,299,000 Genentech, Inc. (I)(L) 137,500 9,754,250 Genzyme Corp. (I) 100,000 5,861,000 Gilead Sciences, Inc. (I) 155,000 5,750,500 Invitrogen Corp. (I)(L) 20,000 1,465,400 Martek Biosciences Corp. (I)(L) 45,000 1,722,150 Nabi Biopharmaceuticals (I) 20,000 218,000 Neurocrine Biosciences, Inc. (I)(L) 50,000 1,748,000 Protein Design Labs, Inc. (I)(L) 130,000 2,324,400 Sepracor, Inc. (I)(L) 35,950 2,154,124 Telik, Inc. (I)(L) 115,000 1,863,000 Vicuron Pharmaceuticals, Inc. (I)(L) 130,000 2,125,500 ZymoGenetics, Inc. (I)(L) 120,000 1,855,200 Health Care Distributors 1.33% 3,539,150 AmerisourceBergen Corp. 20,000 1,225,600 Cardinal Health, Inc. 15,000 833,550 McKesson Corp. 40,000 1,480,000 Health Care Equipment 25.01% 66,608,675 American Medical Systems Holdings, Inc. (I) 150,000 2,619,000 ArthroCare Corp. (I)(L) 110,000 3,231,800 Biomet, Inc. 82,500 3,191,925 Boston Scientific Corp. (I) 186,400 5,513,712 See notes to financial statements. 10 FINANCIAL STATEMENTS Issuer Shares Value Health Care Equipment (continued) DENTSPLY International, Inc. 60,000 $3,279,600 Fisher Scientific International, Inc. (I) 45,000 2,672,100 Gen-Probe, Inc. (I) 85,000 4,266,150 Hospira, Inc. (I) 252,700 8,478,085 Integra LifeSciences Holdings (I) 60,000 2,125,800 Kinetic Concepts, Inc. (I)(L) 80,000 4,916,000 Medtronic, Inc. 250,000 13,175,000 St. Jude Medical, Inc. (I) 110,000 4,293,300 Stryker Corp. (L) 54,000 2,621,700 Varian Medical Systems, Inc. (I)(L) 125,000 4,217,500 Zimmer Holdings, Inc. (I)(L) 24,650 2,007,003 Health Care Facilities 3.54% 9,430,500 Community Health Systems, Inc. (I) 80,000 2,916,000 DaVita, Inc. (I) 75,000 3,022,500 VCA Antech, Inc. (I)(L) 150,000 3,492,000 Health Care Services 11.29% 30,064,764 Advisory Board Co. (The) (I)(L) 70,000 2,849,000 Caremark Rx, Inc. (I) 180,000 7,209,000 Covance, Inc. (I) 90,000 4,107,600 ICON Plc, American Depositary Receipt (ADR) (Ireland) (I)(L) 65,000 2,160,314 IDX Systems Corp. (I) 80,000 2,477,600 Medco Health Solutions, Inc. (I)(L) 90,000 4,587,300 Quest Diagnostics, Inc. 15,000 1,587,000 Stericycle, Inc. (I)(L) 85,000 4,136,950 WebMD Corp. (I)(L) 100,000 950,000 Health Care Supplies 1.87% 4,983,560 Alcon, Inc. (Switzerland) (L) 30,000 2,910,000 Bioenvision, Inc. (I) 125,000 800,000 Retractable Technologies, Inc. (I) 50,000 154,000 Serologicals Corp. (I) 52,000 1,119,560 Managed Health Care 7.01% 18,662,892 PacifiCare Health Systems, Inc. (I) 41,700 2,491,992 UnitedHealth Group, Inc. 90,000 8,505,900 WellPoint, Inc. (I) 60,000 7,665,000 See notes to financial statements. 11 FINANCIAL STATEMENTS Issuer Shares Value Pharmaceuticals 23.15% $61,663,850 Abbot Laboratories 230,000 11,306,800 Aspreva Pharmaceuticals Corp. (I) 74,820 1,086,386 IVAX Corp. (I)(L) 206,050 3,894,345 Johnson & Johnson 120,000 8,235,600 Lilly (Eli) & Co. 95,250 5,569,268 Medicines Co. (The) (I)(L) 120,000 2,562,000 MGI Pharma, Inc. (I) 107,000 2,359,350 Novartis AG (ADR) (Switzerland) 145,000 7,065,850 Pfizer, Inc. 250,000 6,792,500 Roche Holding AG (Switzerland) 45,000 5,466,351 Shire Pharmaceuticals Group Plc, (ADR) (United Kingdom) 100,000 3,108,000 Teva Pharmaceutical Industries Ltd., (ADR) (Israel) 135,000 4,217,400 Interest Par value Issuer, description, maturity date rate (000) Value Short-term investments 29.53% $78,634,820 (Cost $78,634,820) Joint Repurchase Agreement 6.28% 16,718,000 Investment in a joint repurchase agreement transaction with Bank of America Corp. -- Dated 4-29-05 due 5-2-05 (secured by U.S. Treasury STRIPS due 11-15-10 thru 8-15-25) 2.850% $16,718 16,718,000 Shares Cash Equivalents 23.25% 61,916,820 AIM Cash Investment Trust (T) 61,916,820 61,916,820 Total investments 123.57% $329,075,513 Other assets and liabilities, net (23.57%) ($62,767,705) Total net assets 100.00% $266,307,808 See notes to financial statements. 12 FINANCIAL STATEMENTS Notes to Schedule of Investments (I) Non-income-producing security. (L) All or a portion of this security is on loan as of April 30, 2005. (T) Represents investment of securities lending collateral. Parenthetical disclosure of a foreign country in the security description represents country of a foreign issuer. The percentage shown for each investment category is the total value of that category as a percentage of the net assets of the Fund. See notes to financial statements. 13 FINANCIAL STATEMENTS ASSETS AND LIABILITIES April 30, 2005 (unaudited) This Statement of Assets and Liabilities is the Fund's balance sheet. It shows the value of what the Fund owns, is due and owes. You'll also find the net asset value and the maximum offering price per share. Assets Investments, at value (cost $255,264,800) including $60,702,765 of securities loaned $329,075,513 Cash 335 Receivable for shares sold 69,864 Dividends and interest receivable 85,175 Other assets 17,985 Total assets 329,248,872 Liabilities Payable for shares repurchased 294,730 Payable upon return of securities loaned 61,916,820 Payable to affiliates Management fees 537,058 Distribution and service fees 23,217 Other 100,885 Other payables and accrued expenses 68,354 Total liabilities 62,941,064 Net assets Capital paid-in 172,163,121 Accumulated net realized gain on investments and foreign currency transactions 22,349,290 Net unrealized appreciation of investments and translation of assets and liabilities in foreign currencies 73,810,918 Accumulated net investment loss (2,015,521) Net assets $266,307,808 Net asset value per share Based on net asset values and shares outstanding -- the Fund has an unlimited number of shares authorized with no par value Class A ($133,242,143 [DIV] 2,966,779 shares) $44.91 Class B ($120,627,880 [DIV] 2,935,400 shares) $41.09 Class C ($12,437,785 [DIV] 302,660 shares) $41.09 Maximum offering price per share Class A 1 ($44.91 [DIV] 95%) $47.27 1 On single retail sales of less than $50,000. On sales of $50,000 or more and on group sales the offering price is reduced. See notes to financial statements. 14 FINANCIAL STATEMENTS OPERATIONS For the period ended April 30, 2005 (unaudited) 1 This Statement of Operations summarizes the Fund's investment income earned and expenses incurred in operating the Fund. It also shows net gains (losses) for the period stated. Investment income Dividends (net of foreign withholding taxes of $35,809) $529,734 Interest 97,859 Securities lending 48,523 Total investment income 676,116 Expenses Investment management fees 1,055,730 Class A distribution and service fees 195,852 Class B distribution and service fees 648,438 Class C distribution and service fees 65,223 Transfer agent fees 533,948 Printing 47,927 Custodian fees 31,121 Accounting and legal services fees 30,575 Miscellaneous 26,359 Registration and filing fees 21,551 Professional fees 20,997 Trustees' fees 4,723 Securities lending fees 2,319 Total expenses 2,684,763 Net investment loss (2,008,647) Realized and unrealized gain (loss) Net realized gain (loss) on Investments 26,374,943 Foreign currency transactions (2,007) Change in net unrealized appreciation (depreciation) of Investments (4,190,838) Translation of assets and liabilities in foreign currencies (121) Net realized and unrealized gain 22,181,977 Increase in net assets from operations $20,173,330 1 Semiannual period from 11-1-04 through 4-30-05. See notes to financial statements. 15 FINANCIAL STATEMENTS CHANGES IN NET ASSETS These Statements of Changes in Net Assets show how the value of the Fund's net assets has changed during the last two periods. The difference reflects earnings less expenses, any investment gains and losses, distributions, if any, paid to shareholders and the net of Fund share transactions. Year Period ended ended 10-31-04 4-30-05 1 Increase (decrease) in net assets From operations Net investment loss ($4,377,016) ($2,008,647) Net realized gain 22,478,975 26,372,936 Change in net unrealized appreciation (depreciation) 5,299,222 (4,190,959) Increase in net assets resulting from operations 23,401,181 20,173,330 Distributions to shareholders From net realized gain Class A -- (4,490,378) Class B -- (5,195,070) Class C -- (513,947) -- (10,199,395) From Fund share transactions (35,461,797) (15,566,298) Net assets Beginning of period 283,960,787 271,900,171 End of period 2 $271,900,171 $266,307,808 1 Semiannual period from 11-1-04 through 4-30-05. Unaudited. 2 Includes accumulated net investment loss of $6,874 and $2,015,521, respectively. See notes to financial statements. 16 FINANCIAL HIGHLIGHTS FINANCIAL HIGHLIGHTS CLASS A SHARES The Financial Highlights show how the Fund's net asset value for a share has changed since the end of the previous period. Period ended 10-31-00 10-31-01 10-31-02 10-31-03 10-31-04 4-30-05 1 Per share operating performance Net asset value, beginning of period $34.28 $49.99 $40.06 $34.67 $39.79 $43.22 Net investment loss 2 (0.33) (0.37) (0.41) (0.38) (0.47) (0.24) Net realized and unrealized gain (loss) on investments 16.04 (5.99) (4.98) 5.50 3.90 3.50 Total from investment operations 15.71 (6.36) (5.39) 5.12 3.43 3.26 Less distributions From net realized gain -- (3.57) -- -- -- (1.57) Net asset value, end of period $49.99 $40.06 $34.67 $39.79 $43.22 $44.91 Total return 3 (%) 45.83 (13.56) (13.45) 14.77 8.62 7.74 4 Ratios and supplemental data Net assets, end of period (in millions) $178 $145 $110 $117 $125 $133 Ratio of expenses to average net assets (%) 1.50 1.50 1.59 1.67 1.57 1.60 5 Ratio of net investment loss to average net assets (%) (0.75) (0.87) (1.06) (1.04) (1.08) (1.10) 5 Portfolio turnover (%) 147 91 85 95 54 27 See notes to financial statements. 17 FINANCIAL HIGHLIGHTS CLASS B SHARES Period ended 10-31-00 10-31-01 10-31-02 10-31-03 10-31-04 4-30-05 1 Per share operating performance Net asset value, beginning of period $32.83 $47.55 $37.68 $32.39 $36.91 $39.81 Net investment loss 2 (0.60) (0.63) (0.63) (0.59) (0.72) (0.37) Net realized and unrealized gain (loss) on investments 15.32 (5.67) (4.66) 5.11 3.62 3.22 Total from investment operations 14.72 (6.30) (5.29) 4.52 2.90 2.85 Less distributions From net realized gain -- (3.57) -- -- -- (1.57) Net asset value, end of period $47.55 $37.68 $32.39 $36.91 $39.81 $41.09 Total return 3 (%) 44.84 (14.18) (14.04) 13.95 7.86 7.36 4 Ratios and supplemental data Net assets, end of period (in millions) $294 $231 $162 $154 $134 $121 Ratio of expenses to average net assets (%) 2.20 2.20 2.29 2.37 2.27 2.30 5 Ratio of net investment loss to average net assets (%) (1.46) (1.57) (1.76) (1.74) (1.77) (1.81) 5 Portfolio turnover (%) 147 91 85 95 54 27 See notes to financial statements. 18 FINANCIAL HIGHLIGHTS CLASS C SHARES Period ended 10-31-00 10-31-01 10-31-02 10-31-03 10-31-04 4-30-05 1 Per share operating performance Net asset value, beginning of period $32.83 $47.55 $37.68 $32.39 $36.91 $39.81 Net investment loss 2 (0.64) (0.63) (0.63) (0.59) (0.72) (0.37) Net realized and unrealized gain (loss) on investments 15.36 (5.67) (4.66) 5.11 3.62 3.22 Total from investment operations 14.72 (6.30) (5.29) 4.52 2.90 2.85 Less distributions From net realized gain -- (3.57) -- -- -- (1.57) Net asset value, end of period $47.55 $37.68 $32.39 $36.91 $39.81 $41.09 Total return 3 (%) 44.84 (14.18) (14.04) 13.95 7.86 7.36 4 Ratios and supplemental data Net assets, end of period (in millions) $14 $15 $12 $13 $13 $12 Ratio of expenses to average net assets (%) 2.20 2.20 2.29 2.37 2.27 2.30 5 Ratio of net investment loss to average net assets (%) (1.50) (1.58) (1.76) (1.73) (1.78) (1.80) 5 Portfolio turnover (%) 147 91 85 95 54 27 1 Semiannual period from 11-1-04 through 4-30-05. Unaudited. 2 Based on the average of the shares outstanding. 3 Assumes dividend reinvestment and does not reflect the effect of sales charges. 4 Not annualized. 5 Annualized. See notes to financial statements. 19 NOTES TO STATEMENTS Unaudited Note A Accounting policies John Hancock Health Sciences Fund (the "Fund") is a non-diversified series of John Hancock World Fund, an open-end management investment company registered under the Investment Company Act of 1940. The investment objective of the Fund is to achieve long-term growth of capital. The Trustees have authorized the issuance of multiple classes of shares of the Fund, designated as Class A, Class B and Class C shares. The shares of each class represent an interest in the same portfolio of investments of the Fund and have equal rights as to voting, redemptions, dividends and liquidation, except that certain expenses, subject to the approval of the Trustees, may be applied differently to each class of shares in accordance with current regulations of the Securities and Exchange Commission and the Internal Revenue Service. Shareholders of a class that bears distribution and service expenses under the terms of a distribution plan have exclusive voting rights to that distribution plan. Significant accounting policies of the Fund are as follows: Valuation of investments Securities in the Fund's portfolio are valued on the basis of market quotations, valuations provided by independent pricing services or, if quotations are not readily available, or the value has been materially affected by events occurring after the close of a foreign market, at fair value as determined in good faith in accordance with procedures approved by the Trustees. Short-term debt investments which have a remaining maturity of 60 days or less may be valued at amortized cost, which approximates market value. Investments in AIM Cash Investment Trust are valued at their net asset value each business day. All portfolio transactions initially expressed in terms of foreign currencies have been translated into U.S. dollars as described in "Foreign currency translation" below. Joint repurchase agreement Pursuant to an exemptive order issued by the Securities and Exchange Commission, the Fund, along with other registered investment companies having a management contract with John Hancock Advisers, LLC (the "Adviser"), a wholly owned subsidiary of John Hancock Financial Services, Inc., may participate in a joint repurchase agreement transaction. Aggregate cash balances are invested in one or more large repurchase agreements, whose underlying securities are obligations of the U.S. government and/or its agencies. The Fund's custodian bank receives delivery of the underlying securities for the joint account on the Fund's behalf. The Adviser is responsible for ensuring that the agreement is fully collateralized at all times. 20 Foreign currency translation All assets or liabilities initially expressed in terms of foreign currencies are translated into U.S. dollars based on London currency exchange quotations as of 4:00 P.M., London time, on the date of any determination of the net asset value of the Fund. Transactions affecting statement of operations accounts and net realized gain (loss) on investments are translated at the rates prevailing at the dates of the transactions. The Fund does not isolate that portion of the results of operations resulting from changes in foreign exchange rates on investments from the fluctuations arising from changes in market prices of securities held. Such fluctuations are included with the net realized and unrealized gain or loss from investments. Reported net realized foreign currency exchange gains or losses arise from sales of foreign currency, currency gains or losses realized between the trade and settlement dates on securities transactions, and the difference between the amounts of dividends, interest and foreign withholding taxes recorded on the Fund's books and the U.S. dollar equivalent of the amounts actually received or paid. Net unrealized foreign currency exchange gains and losses arise from changes in the value of assets and liabilities, other than investments in securities, resulting from changes in the exchange rates. Investment transactions Investment transactions are recorded as of the date of purchase, sale or maturity. Net realized gains and losses on sales of investments are determined on the identified cost basis. Capital gains realized on some foreign securities are subject to foreign taxes, which are accrued as applicable. Class allocations Income, common expenses and realized and unrealized gains (losses) are determined at the fund level and allocated daily to each class of shares based on the appropriate net asset value of the respective classes. Distribu tion and service fees, if any, are calculated daily at the class level based on the appropriate net asset value of each class and the specific expense rate(s) applicable to each class. Expenses The majority of expenses are directly identifiable to an individual fund. Expenses that are not readily identifiable to a specific fund are allocated in such a manner as deemed equitable, taking into consideration, among other things, the nature and type of expense and the relative sizes of the funds. Bank borrowings The Fund is permitted to have bank borrowings for temporary or emergency purposes, including the meeting of redemption requests that otherwise might require the untimely disposition of securities. The Fund has entered into a syndicated line of credit agreement with various banks. This agreement enables the Fund to participate, with other funds managed by the Adviser, in an unsecured line of credit with banks, which permits borrowings of up to $250 million, collectively. Interest is charged to each fund based on its borrowing. In addition, a commitment fee is charged to each fund based on the average daily unused portion of the line of credit, and is allocated among the participating funds. The Fund had no borrowing activity under the line of credit during the period ended April 30, 2005. Securities lending The Fund may lend securities to certain qualified brokers who pay the Fund negotiated lender fees. The loans are collateralized at all times with cash or securities with a market value at least equal to the market value of the securities on loan. As with other extensions of credit, the Fund may bear the risk of delay of the loaned securities in recovery or even loss of rights in the collateral, should the borrower of the securities fail financially. On April 30, 2005, the Fund loaned securities having a market value of $60,702,765 collateralized by cash in the 21 amount of $61,916,820. The cash collateral was invested in a short-term instrument. Securities lending expenses are paid by the Fund to the Adviser. Forward foreign currency exchange contracts The Fund may enter into forward foreign currency exchange contracts as a hedge against the effect of fluctuations in currency exchange rates. A forward foreign currency exchange contract involves an obligation to purchase or sell a specific currency at a future date at a set price. The aggregate principal amounts of the contracts are marked to market daily at the applicable foreign currency exchange rates. Any resulting unrealized gains and losses are included in the determination of the Fund's daily net asset value. The Fund records realized gains and losses at the time the forward foreign currency exchange contracts are closed out. Risks may arise upon entering these contracts from the potential inability of counterparties to meet the terms of the contracts and from unanticipated movements in the value of a foreign currency relative to the U.S. dollar. These contracts involve market or credit risk in excess of the unrealized gain or loss reflected in the Fund's Statement of Assets and Liabilities. The Fund may also purchase and sell forward contracts to facilitate the settlement of foreign currency denominated portfolio transactions, under which it intends to take delivery of the foreign currency. Such contracts normally involve no market risk if they are offset by the currency amount of the underlying transactions. The Fund had no open forward foreign currency exchange contracts on April 30, 2005. Federal income taxes The Fund qualifies as a "regulated investment company" by complying with the applicable provisions of the Internal Revenue Code and will not be subject to federal income tax on taxable income that is distributed to shareholders. Therefore, no federal income tax provision is required. Dividends, interest and distributions Dividend income on investment securities is recorded on the ex-dividend date or, in the case of some foreign securities, on the date thereafter when the Fund identifies the dividend. Interest income on investment securities is recorded on the accrual basis. Foreign income may be subject to foreign withholding taxes, which are accrued as applicable. The Fund records distributions to shareholders from net investment income and net realized gains, if any, on the ex-dividend date. Dis tri bu tions paid by the Fund with respect to each class of shares are calculated in the same manner, at the same time and are in the same amount, except for the effect of expenses that may be applied differently to each class. Such distributions, on a tax basis, are determined in conformity with income tax regulations, which may differ from accounting principles generally accepted in the United States of America. Distributions in excess of tax basis earnings and profits, if any, are reported in the Fund's financial statements as a return of capital. Use of estimates The preparation of these financial statements, in accordance with accounting principles generally accepted in the United States of America, incorporates estimates made by management in determining the reported amount of assets, liabilities, revenues and expenses of the Fund. Actual results could differ from these estimates. Note B Management fee and transactions with affiliates and others The Fund has an investment management contract with the Adviser. Under the investment management contract, the Fund pays a quarterly management fee to the Adviser equivalent, on an annual basis, to the 22 sum of: (a) 0.80% of the first $200,000,000 of the Fund's average daily net asset value and (b) 0.70% of the Fund's daily average net asset value in excess of $200,000,000. The Fund has Distribution Plans with John Hancock Funds, LLC ("JH Funds"), a wholly owned subsidiary of the Adviser. The Fund has adopted Distribution Plans with respect to Class A, Class B and Class C, pursuant to Rule 12b-1 under the Investment Company Act of 1940, to reimburse JH Funds for the services it provides as distributor of shares of the Fund. Accordingly, the Fund makes monthly payments to JH Funds at an annual rate not to exceed 0.30% of Class A average daily net asset value and 1.00% of Class B and Class C average daily net asset value. A maximum of 0.25% of such payments may be service fees, as defined by the Conduct Rules of the National Association of Securities Dealers. Under the Conduct Rules, curtailment of a portion of the Fund's 12b-1 payments could occur under certain circumstances. Class A shares are assessed up-front sales charges. During the period ended April 30, 2005, JH Funds received net up-front sales charges of $82,103 with regard to sales of Class A shares. Of this amount, $11,517 was retained and used for printing prospectuses, advertising, sales literature and other purposes, $54,546 was paid as sales commissions to unrelated broker-dealers and $16,040 was paid as sales commissions to sales personnel of Signator Investors, Inc. ("Signator Investors"), a related broker-dealer. The Adviser's indirect parent, John Hancock Life Insurance Company ("JHLICo"), is the indirect sole shareholder of Signator Investors. Class B shares that are redeemed within six years of purchase are subject to a contingent deferred sales charge ("CDSC") at declining rates, beginning at 5.00% of the lesser of the current market value at the time of redemption or the original purchase cost of the shares being redeemed. Class C shares that are redeemed within one year of purchase are subject to a CDSC at a rate of 1.00% of the lesser of the current market value at the time of redemption or the original purchase cost of the shares being redeemed. Proceeds from the CDSCs are paid to JH Funds and are used, in whole or in part, to defray its expenses for providing distribution-related services to the Fund in connection with the sale of Class B and Class C shares. During the period ended April 30, 2005, CDSCs received by JH Funds amounted to $125,967 for Class B shares and $404 for Class C shares. The Fund has a transfer agent agreement with John Hancock Signature Services, Inc. ("Signature Services"), an indirect subsidiary of JHLICo. For Class A, Class B and Class C shares, the Fund pays a monthly transfer agent fee at an annual rate of 0.05% of each class's average daily net asset value, plus a fee based on the number of shareholder accounts and reimbursement for certain out-of-pocket expenses aggregated and allocated to each class on the basis of its relative net asset value. Signature Services agreed to voluntarily reduce the Fund's asset-based portion of the transfer agent fee if the total transfer agent fee exceeds the Lipper, Inc. median transfer agency fee for comparable mutual funds by 0.05%. There were no transfer agent fee reductions during the period ended April 30, 2005. Signature Services reserves the right to terminate this limitation at any time. The Fund has an agreement with the Adviser to perform necessary tax, accounting and legal services for the Fund. The compensation for the period amounted to $30,575. The Fund also paid the Adviser the amount of $116 for certain publishing services, included in the printing fees. Mr. James A. Shepherdson is a director and officer of the 23 Adviser, as well as affiliated Trustee of the Fund, and is compensated by the Adviser. The compensation of unaffiliated Trustees is borne by the Fund. The unaffiliated Trustees may elect to defer, for tax purposes, their receipt of this compensation under the John Hancock Group of Funds Deferred Compensation Plan. The Fund makes investments into other John Hancock funds, as applicable, to cover its liability for the deferred compensation. Investments to cover the Fund's deferred compensation liability are recorded on the Fund's books as an other asset. The deferred compensation liability and the related other asset are always equal and are marked to market on a periodic basis to reflect any income earned by the investments, as well as any unrealized gains or losses. The Deferred Compensation Plan investments had no impact on the operations of the Fund. Note C Fund share transactions This listing illustrates the number of Fund shares sold, reinvested and repurchased during the last two periods, along with the corresponding dollar value. Year Ended 10-31-04 Period Ended 4-30-05 1 Shares Amount Shares Amount Class A shares Sold 838,297 $37,031,926 347,040 $15,406,316 Distributions reinvested -- -- 100,940 4,292,992 Repurchased (881,741) (38,668,127) (376,474) (16,755,833) Net increase (decrease) (43,444) ($1,636,201) 71,506 $2,943,475 Class B shares Sold 570,109 $22,972,932 94,296 $3,860,748 Distributions reinvested -- -- 127,562 4,978,739 Repurchased (1,396,371) (56,382,735) (641,347) (26,131,324) Net decrease (826,262) ($33,409,803) (419,489) ($17,291,837) Class C shares Sold 92,939 $3,788,765 26,451 $1,083,857 Distributions reinvested -- -- 10,062 392,718 Repurchased (105,002) (4,204,558) (65,963) (2,694,511) Net decrease (12,063) ($415,793) (29,450) ($1,217,936) Net decrease (881,769) ($35,461,797) (377,433) ($15,566,298) 1 Semiannual period from 11-1-04 through 4-30-05. Unaudited. Note D Investment transactions Purchases and proceeds from sales or maturities of securities, other than short-term securities and obligations of the U.S. government, during the period ended April 30, 2005, aggregated $70,688,447 and $104,559,633, respectively. The cost of investments owned on April 30, 2005, including short-term investments, for federal income tax purposes, was $257,528,031. Gross unrealized appreciation and depreciation of investments aggregated $75,628,704 and $4,081,222, respectively, resulting in net unrealized appreciation of 24 $71,547,482. The difference between book basis and tax basis net unrealized appreciation of investments is attributable primarily to the tax deferral of losses certain sales of securities. Note E Proposed reorganization On March 8, 2005, the Trustees approved the reorganization of John Hancock Biotechnology Fund into the Fund. The reorganization is scheduled to take place after the close of business on June 10, 2005, subject to approval by shareholders. Note F Shareholder meeting On December 1, 2004, a Special Meeting of shareholders of the Fund was held to elect nine Trustees effective January 1, 2005. Proxies covering 5,416,269 shares of beneficial interest were voted at the meeting. The shareholders elected the following Trustees to serve until their respective successors are duly elected and qualified, with the votes tabulated as follows: WITHHELD FOR AUTHORITY - --------------------------------------------------------------------- James F. Carlin 5,298,019 118,250 Richard P. Chapman, Jr. 5,292,095 124,174 William H. Cunningham 5,292,069 124,200 Ronald R. Dion 5,296,819 119,450 Charles L. Ladner 5,293,897 122,372 Dr. John A. Moore 5,293,818 122,451 Patti McGill Peterson 5,291,747 124,522 Steven R. Pruchansky 5,294,370 121,899 James A. Shepherdson 5,293,700 122,569 25 OUR FAMILY OF FUNDS - ----------------------------------------------------------- Equity Balanced Fund Classic Value Fund Core Equity Fund Focused Equity Fund Greater China Opportunities Fund Growth Trends Fund International Fund Large Cap Equity Fund Large Cap Select Fund Mid Cap Growth Fund Multi Cap Growth Fund Small Cap Fund Small Cap Equity Fund Small Cap Growth Fund Sovereign Investors Fund U.S. Global Leaders Growth Fund - ----------------------------------------------------------- Sector Financial Industries Fund Health Sciences Fund Real Estate Fund Regional Bank Fund Technology Fund - ----------------------------------------------------------- Income Bond Fund Government Income Fund High Income Fund High Yield Fund Investment Grade Bond Fund Strategic Income Fund - ----------------------------------------------------------- Tax-Free Income California Tax-Free Income Fund High Yield Municipal Bond Fund Massachusetts Tax-Free Income Fund New York Tax-Free Income Fund Tax-Free Bond Fund - ----------------------------------------------------------- Money Market Money Market Fund U.S. Government Cash Reserve A fund's investment objectives, risks, charges and expenses are included in the prospectus and should be considered carefully before investing. For a prospectus, call your financial professional, call John Hancock Funds at 1-800-225-5291 or visit our Web site at www.jhfunds.com. Please read the prospectus carefully before investing or sending money. 26 ELECTRONIC DELIVERY Now available from John Hancock Funds Instead of sending annual and semiannual reports and prospectuses through the U.S. mail, we'll notify you by e-mail when these documents are available for online viewing. How does electronic delivery benefit you? * No more waiting for the mail to arrive; you'll receive an e-mail notification as soon as the document is ready for online viewing. * Reduces the amount of paper mail you receive from John Hancock Funds. * Reduces costs associated with printing and mailing. Sign up for electronic delivery today at www.jhfunds.com/edelivery 27 OUR WEB SITE A wealth of information -- www.jhfunds.com View the latest information for your account. - ------------------------------------------------ Transfer money from one account to another. - ------------------------------------------------ Get current quotes for major market indexes. - ------------------------------------------------ Use our online calculators to help you with your financial goals. - ------------------------------------------------ Get up-to-date commentary from John Hancock Funds investment experts. - ------------------------------------------------ Access forms, applications and tax information. - ------------------------------------------------ 28 For more information The Fund's proxy voting policies, procedures and records are available without charge, upon request: By phone On the Fund's Web site On the SEC's Web site 1-800-225-5291 www.jhfunds.com/proxy www.sec.gov Trustees Charles L. Ladner, Chairman* James F. Carlin Richard P. Chapman, Jr.* William H. Cunningham Ronald R. Dion Dr. John A. Moore* Patti McGill Peterson* Steven R. Pruchansky James A. Shepherdson Lt. Gen. Norman H. Smith, USMC (Ret.) *Members of the Audit Committee Officers James A. Shepherdson President and Chief Executive Officer William H. King Vice President and Treasurer Investment adviser John Hancock Advisers, LLC 101 Huntington Avenue Boston, MA 02199-7603 Principal distributor John Hancock Funds, LLC 101 Huntington Avenue Boston, MA 02199-7603 Custodian The Bank of New York One Wall Street New York, NY 10286 Transfer agent John Hancock Signature Services, Inc. 1 John Hancock Way, Suite 1000 Boston, MA 02217-1000 Legal counsel Wilmer Cutler Pickering Hale and Dorr LLP 60 State Street Boston, MA 02109-1803 The Fund's investment objective, risks, charges and expenses are included in the prospectus and should be considered carefully before investing. For a prospectus, call your financial professional, call John Hancock Funds at 1-800-225-5291, or visit the Fund's Web site at www.jhfunds.com. Please read the prospectus carefully before investing or sending money. How to contact us Internet www.jhfunds.com Mail Regular mail: Express mail: John Hancock John Hancock Signature Services, Inc. Signature Services, Inc. 1 John Hancock Way, Suite 1000 Mutual Fund Image Operations Boston, MA 02217-1000 529 Main Street Charlestown, MA 02129 Phone Customer service representatives 1-800-225-5291 24-hour automated information 1-800-338-8080 TDD line 1-800-554-6713 A listing of month-end portfolio holdings is available on our Web site, www.jhfunds.com. A more detailed portfolio holdings summary is available on a quarterly basis 60 days after the fiscal quarter on our Web site or upon request by calling 1-800-225-5291, or on the Securities and Exchange Commission's Web site, www.sec.gov. 29 [A 1 1/2" x 1/2" John Hancock (Signature) logo in upper left hand corner. A tag line below reads "JOHN HANCOCK FUNDS."] 1-800-225-5291 1-800-554-6713 (TDD) 1-800-338-8080 EASI-Line www.jhfunds.com Now available: electronic delivery www.jhfunds.com/edelivery This report is for the information of the shareholders of John Hancock Health Sciences Fund. 280SA 4/05 6/05 ITEM 2. CODE OF ETHICS. As of the end of the period, April 30, 2005, the registrant has adopted a code of ethics, as defined in Item 2 of Form N-CSR, that applies to its Chief Executive Officer, Chief Financial Officer and Treasurer (respectively, the principal executive officer, the principal financial officer and the principal accounting officer, the "Senior Financial Officers"). A copy of the code of ethics is filed as an exhibit to this Form N-CSR. The code of ethics was amended effective February 1, 2005 to address new Rule 204A-1 under the Investment Advisers Act of 1940 and to make other related changes. The most significant amendments were: (a) Broadening of the General Principles of the code to cover compliance with all federal securities laws. (b) Eliminating the interim requirements (since the first quarter of 2004) for access persons to preclear their personal trades of John Hancock mutual funds. This was replaced by post-trade reporting and a 30 day hold requirement for all employees. (c) A new requirement for "heightened preclearance" with investment supervisors by any access person trading in a personal position worth $100,000 or more. ITEM 3. AUDIT COMMITTEE FINANCIAL EXPERT. Not applicable at this time. ITEM 4. PRINCIPAL ACCOUNTANT FEES AND SERVICES. Not applicable at this time. ITEM 5. AUDIT COMMITTEE OF LISTED REGISTRANTS. Not applicable at this time. ITEM 6. SCHEDULE OF INVESTMENTS. Not applicable. ITEM 7. DISCLOSURE OF PROXY VOTING POLICIES AND PROCEDURES FOR CLOSED-END MANAGEMENT INVESTMENT COMPANIES. Not applicable. ITEM 8. PORTFOLIO MANAGERS OF CLOSED-END MANAGEMENT INVESTMENT COMPANIES. Not applicable. ITEM 9. PURCHASES OF EQUITY SECURITIES BY CLOSED-END MANAGEMENT INVESTMENT COMPANY AND AFFILIATED PURCHASERS. Not applicable. ITEM 10. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS. The registrant has adopted procedures by which shareholders may recommend nominees to the registrant's Board of Trustees. A copy of the procedures is filed as an exhibit to this Form N-CSR. See attached "John Hancock Funds - Administration Committee Charter" and "John Hancock Funds - Governance Committee Charter". ITEM 11. CONTROLS AND PROCEDURES. (a) Based upon their evaluation of the registrant's disclosure controls and procedures as conducted within 90 days of the filing date of this Form N-CSR, the registrant's principal executive officer and principal financial officer have concluded that those disclosure controls and procedures provide reasonable assurance that the material information required to be disclosed by the registrant on this report is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission's rules and forms. (b) There were no changes in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal half-year (the registrant's second fiscal half-year in the case of an annual report) that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting. ITEM 12. EXHIBITS. (a)(1) Code of Ethics for Senior Financial Officers is attached. (a)(2) Separate certifications for the registrant's principal executive officer and principal financial officer, as required by Section 302 of the Sarbanes-Oxley Act of 2002 and Rule 30a-2(a) under the Investment Company Act of 1940, are attached. (b) Separate certifications for the registrant's principal executive officer and principal financial officer, as required by 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, and Rule 30a-2(b) under the Investment Company Act of 1940, are attached. The certifications furnished pursuant to this paragraph are not deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, or otherwise subject to the liability of that section. Such certifications are not deemed to be incorporated by reference into any filing under the Securities Act of 1933 or the Securities Exchange Act of 1934, except to the extent that the Registrant specifically incorporates them by reference. (c)(1) Submission of Matters to a Vote of Security Holders is attached. See attached "John Hancock Funds - Administration Committee Charter" and "John Hancock Funds - Governance Committee Charter". (c)(2) Contact person at the registrant. SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. John Hancock World Fund By: ------------------------------ James A. Shepherdson President and Chief Executive Officer Date: June 30, 2005 Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated. By: ------------------------------ James A. Shepherdson President and Chief Executive Officer Date: June 30, 2005 By: ------------------------------ William H. King Vice President and Treasurer Date: June 30, 2005