EXHIBIT 4.3

                           CERTIFICATE OF AMENDMENT
                                     OF
                                  RESTATED
                         CERTIFICATE OF INCORPORATION
                                      OF
                             McKESSON CORPORATION

- -------------------------------------------------------------------------------

                     Pursuant to Sections 222 and 242 of
                      the General Corporation Law of the
                              State of Delaware
 
- -------------------------------------------------------------------------------


        McKesson Corporation, a corporation organized and existing under and by 

virtue of the provisions of the General Corporation Law of the State of 

Delaware (the "Corporation"), does hereby certify as follows:


        FIRST: That Article I of the Corporation's Restated Certificate of 
Incorporation is hereby amended to read in its entirety as set forth below:

                                   ARTICLE I

        The name of the Corporation is McKesson HBOC, Inc.

        SECOND: That the foregoing amendment was duly adopted in accordance with
the provisions of Sections 222 and 242 of the General Corporation Law of the 
State of Delaware.




 
        IN WITNESS WHEREOF, McKesson Corporation has caused this Certificate

to be executed in its corporate name this 12th day of January, 1999.



                          McKESSON CORPORATION

                          By /s/ Nancy A. Miller
                             ---------------------------------------------
                                 Name:  Nancy A. Miller
                                 Title: Vice President and Corporate Secretary



                                       2