Exhibit 21 Subsidiaries of Integra LifeSciences Holdings Corporation State or Country of Name of Subsidiary Incorporation or Organization - ------------------ ----------------------------- 1. Camino NeuroCare, Inc. Delaware 2. Heyer-Schulte NeuroCare, Inc. Delaware 3. Integra LifeSciences Corporation Delaware 4. Integra NeuroCare LLC Delaware 5. NeuroCare Holding Corporation Delaware 6. Telios Pharmaceuticals, Inc. Delaware 7. CNS Holdings LLC Delaware 8. Clinical Neuro Systems LLC Delaware 9. Caveangle Corporation United Kingdom 10. Integra NeuroSciences Holdings Ltd. United Kingdom 11. Integra NeuroSciences Ltd. United Kingdom 12. Spembly Medical Ltd. United Kingdom