Exhibit 99.1


               DATED                                          2004
               ---------------------------------------------------


                           CRAIG RENNIE AND OTHERS (1)

                                       AND

                      CELGENE UK MANUFACTURING LIMITED (2)

                                       AND

                             CELGENE CORPORATION (3)












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                           SHARE ACQUISITION AGREEMENT
                             FOR THE PURCHASE OF THE
                         ENTIRE ISSUED SHARE CAPITAL OF
                                 PENN T LIMITED

- --------------------------------------------------------------------------------














                              BARLOW LYDE & GILBERT
               BEAUFORT HOUSE 15 ST BOTOLPH STREET LONDON EC3A 7NJ
                   TELEPHONE +44 [0] 20 7247 2277 FAX +44 [0]
                                  20 7071 9000
                     WEBSITE WWW.BLG.CO.UK DX 155 LONDON CDE




                                    CONTENTS
CLAUSE                                                                      PAGE
1        DEFINITIONS AND INTERPRETATION........................................1
2        SALE AND PURCHASE....................................................10
3        CONSIDERATION........................................................11
4        COMPLETION...........................................................13
5        POST-COMPLETION MATTERS..............................................14
6        WARRANTIES AND REPRESENTATIONS.......................................14
7        RESTRICTIVE COVENANTS IN FAVOUR OF THE PURCHASER.....................17
8        PAYMENTS.............................................................18
9        GENERAL..............................................................19
10       CHOICE OF LAW, SUBMISSION TO JURISDICTION AND SERVICE OF PROCESS.....24
11       TERMINATION..........................................................26
12       OPTION AGREEMENT: CONFLICT AND SURVIVAL..............................26
13       VENDORS' REPRESENTATIVES AND WARRANTORS' REPRESENTATIVE..............26
14       PENN SHARES - RIGHT OF FIRST REFUSAL AND LAST REFUSAL................27
15       CELGENE GUARANTEE....................................................27

SCHEDULES
1        The Company..........................................................28
2        Completion Matters...................................................29
3        Tax..................................................................34
         Part 1 - General.....................................................34
         Part 2 - Taxation Covenant...........................................46
         Part 3 - Taxation Warranties.........................................49
4        Part 1 - The Warranties..............................................55
         Part 2 - The Representations.........................................75
5        Part 1 - The Vendors.................................................76
         Part 2 - The Warrantors..............................................78
6        The Completion Accounts..............................................80
7        Provisions for the protection of the Warrantors......................83
8        Rights of First Refusal and Last Refusal.............................89
9        Celgene Guarantee....................................................94
10       Trustees Covenants and Warranties....................................96
11       Relevant documents for paragraph 1.1 of part 1 of Schedule 4.........98

ANNEXURES

1.       Celgene Pharmion Agreement..........................................100
2.       Penn Celgene Manufacturing Agreement................................101
3.       Option Agreement....................................................102
4.       Articles of Association of Penn.....................................103




AGREED FORM DOCUMENTS

Acknowledgement and Release
Officers' resignations
Powers of attorney pending registration of the Sale Shares
Auditors' resignation
Deed of Termination
Escrow Deed
Deed of Release and Consent
Escrow Account Instruction Letter
Run-Off Insurance Confirmation Letter
Technical Services Agreement




THIS AGREEMENT is dated                      2004 and is made as a deed BETWEEN:

(1)     THE PERSONS whose names and addresses are stated in part 1 of schedule 5
        (together THE "VENDORS");

(2)     CELGENE UK MANUFACTURING  LIMITED, a company incorporated in England and
        Wales under  number  5262329  whose  registered  office is at 7th Floor,
        Beaufort House, 15 St Botolph Street, London EC3A 7NJ (the "PURCHASER");
        and

(3)     CELGENE  CORPORATION,  a Delaware  corporation  whose principal place of
        business  is  at  7  Powder  Horn  Drive,   Warren,   New  Jersey  07059
        ("CELGENE");

(together "THE PARTIES" and each a "PARTY").

NOW IT IS HEREBY AGREED as follows:

1       DEFINITIONS AND INTERPRETATION

1.1     Defined terms used in this Agreement
        ------------------------------------

        In this Agreement, unless the context otherwise requires:

        "ACTUAL TAXATION  LIABILITY" has the meaning given in part 1 of schedule
        3;

        "AGGREGATE THRESHOLD" means (pound)275,000;

        "AUDITORS"  means  PricewaterhouseCoopers  LLP of One Kingsway,  Cardiff
        CF10 3PW;

        "BUSINESS"  means the business carried on by the Company prior to and at
        the Completion  Date being the  procurement of manufacture  and the sale
        and/or distribution of Sauramide, Thalomid, Pharmion Thalidomide and any
        formulation that contains thalidomide;

        "BUSINESS  DAY" means a day other  than a Saturday  or a Sunday on which
        clearing banks are open for business in London for dealings in Sterling;

        "BL&H AGREEMENT" means the distributorship agreement between the Company
        and BL&H International  Corp., as amended and restated from time to time
        prior to the date hereof;

        "CASH"  means  the  cash  book  balance  of the  Company  at the time of
        Completion  (taking into  account cash at bank and in hand,  unpresented
        cheques  issued by the Company prior to such time and uncleared  cheques
        in favour of the Company prior to such time);

        "CA 1985" means the Companies Act 1985;

        "CELGENE  AFFILIATE"  means any entity  which is  controlled  by,  under
        common  control with, or in control of,  Celgene and for the purposes of
        this definition,

                                       1



        "control"  shall  mean the power  whether  by reason of voting  control,
        contract  rights or otherwise,  to direct the business and affairs of an
        entity;

        "CELGENE  LICENSEE"  means any  entity  that is  licensed  or  otherwise
        authorised by Celgene or a Celgene  Affiliate to manufacture,  market or
        sell any  formulation  containing  thalidomide or  thalidomide  analogs,
        homologs  or  prodrugs  thereof,  including,   without  limitation,  the
        thalidomide drugs known as Thalomid,  Sauramide and Pharmion Thalidomide
        and any formulation that contains thalidomide;

        "CELGENE  PHARMION  AGREEMENT"  means  the  licence  agreement  dated 16
        November  2001 between  Celgene (1) and  Pharmion  GmbH (2) and Pharmion
        Corporation  (3) (as amended and restated from time to time prior to the
        date hereof);

        "CLOSING  CURRENT ASSETS" means all current assets of the Company at the
        time of  Completion as set out in the Closing  Balance  Sheet  including
        stock, Cash and amounts due from trade debtors and other receivables;

        "CLOSING  BALANCE SHEET" means the audited  balance sheet of the Company
        as at the  time of  Completion,  as set out in the  Completion  Accounts
        prepared in accordance with Schedule 6;

        "CLOSING  DEBT"  means all sums or amounts  due from the  Company at the
        time of Completion  to third  parties in the form of loans,  overdrafts,
        guarantees or other  indebtedness for borrowed money (excluding the Penn
        Group  Indebtedness,  the  RBS  Indebtedness  and  the  Closing  Current
        Liabilities)  as set out in the Closing  Balance  Sheet  (including  any
        accrued interest and early repayment charges);

        "CLOSING  CURRENT  LIABILITIES"  means all  current  liabilities  of the
        Company  at the time of  Completion  as set out in the  Closing  Balance
        Sheet  including  trade  creditors  and accruals  and other  liabilities
        (including Tax);

        "CLOSING NET  FINANCIAL  POSITION"  means  Closing  Current  Assets less
        Closing Current  Liabilities  (and also less Closing Debt, to the extent
        the same is not repaid by the Company on or prior to Completion);

        "COMPANY" means Penn T Limited (No.  4272045),  further details of which
        are set out in schedule 1;

        "COMPLETION"  means completion of the sale and purchase of the Shares by
        the  performance by the Parties of their  respective  obligations  under
        clause 4.1 and schedule 2;

        "COMPLETION  ACCOUNTS"  means an audited  profit and loss account of the
        Company  from  and  including  1  April  2004  up to and  including  the
        Completion Date and the Closing Balance Sheet, together with a statement
        of the Closing Net Financial  Position and a cash flow statement for the
        same period or as at the  Completion  Date, to be prepared in accordance
        with Schedule 6;

                                       2



        "COMPLETION   DATE"  means  the  date  on  which  Completion  occurs  in
        accordance with the terms of this Agreement;

        "CONFIDENTIAL  INFORMATION"  means all  information  and data including,
        without  limitation,  proprietary  information and materials (whether or
        not patentable) regarding the Company's technology,  products,  business
        information  or  objectives,  as well as trade  secrets and  information
        equivalent  to them of the  Company  (including,  but  not  limited  to,
        formulae, processes, methods, knowledge and Know-how) in connection with
        the Business  including  (without  limitation) that which relates to the
        customers  and  suppliers  relating  thereto  and which are for the time
        being confidential;

        "DEED OF RELEASE AND  CONSENT"  means the deed of release and consent in
        the agreed form to be executed and delivered on Completion by Royal Bank
        of Scotland plc (and others), in favour of the Company releasing it from
        obligations under a Guarantee,  Debenture and  Inter-Creditor  Agreement
        and  confirming  that there are no amounts  owing by the Company to such
        bankers;

        "DEED OF TERMINATION"  means a deed of termination,  in the agreed form,
        terminating, with effect from the Completion Date, the Option Agreement;

        "DISCLOSURE  LETTER"  means the  letter  (including  its  annexures  and
        documents and matters deemed  incorporated  therein) of the same date as
        this  Agreement  from the  Warrantors  to the Purchaser  containing  the
        disclosures  to the Warranties  and the  Representations  which has been
        delivered to the Purchaser prior to the execution of this Agreement;

        "ESCROW  ACCOUNT" means the UK sterling account details of which are set
        out in the Escrow Deed;

        "ESCROW ACCOUNT  INSTRUCTION LETTER" means the letter in the agreed form
        to be given to the Purchaser's Solicitors and the Vendors' Solicitors by
        the Purchaser, Celgene and the Vendors;

        "ESCROW  AMOUNT" means the sum of  (pound)2,800,000  to be paid into the
        Escrow  AccounT  on  Completion  and dealt with in  accordance  with the
        provisions of the Escrow Deed;

        "ESCROW  DEED"  means the deed of  escrow,  in the  agreed  form,  to be
        entered into on Completion by the Warrantors and the Purchaser;

        "GUARANTEE"  means  any  guarantee,  indemnity,  suretyship,  letter  of
        comfort or any other  assurance,  security or right of set-off  given or
        undertaken  directly or  indirectly by a person to secure or support the
        obligations (actual or contingent) of any third party;

        "HOLDING  COMPANY"  means a holding  company (as defined in sections 736
        and 736A CA 1985) or a parent  undertaking (as defined in section 258 CA
        1985);

        "ICTA" means the Income and Corporation Taxes Act 1988;

                                       3



        "INDEPENDENT  ACCOUNTANT" means a single chartered accountant or firm of
        chartered  accountants,  nominated  by  agreement  between the  Vendors'
        Representatives  and the  Purchaser  or, in  default  of such  agreement
        within 15 Business  Days after the date upon which the relevant  dispute
        arises,  nominated by the  President for the time being of the Institute
        of Chartered Accountants in England and Wales (or by such person as such
        President may appoint for the purpose of making such  nomination) on the
        application of the Vendors' Representatives or the Purchaser;

        "INDIVIDUAL THRESHOLD" means (pound)27,500;

                                                            95(A - B)
        "INITIAL PAYMENT" means (pound)51,117,533.69 being ----------- where:-
                                                               100

        A = (pound)61,750,000; and

        B  =  the  aggregate  of  the  Penn  Group   Indebtedness  and  the  RBS
        Indebtedness;

        "INTELLECTUAL PROPERTY" means:

        (i)     patents,   trade  marks,  service  marks,   registered  designs,
                applications  for any of those rights,  trade and business names
                (including  internet  domain  names and e-mail  address  names),
                unregistered trade marks and service marks,  copyrights,  design
                rights and rights in semiconductor  topographies,  moral rights,
                rights in performances (as set out in Part II Copyright  Designs
                and Patents Act 1988),  database rights,  rights in know-how and
                designs and inventions;

        (ii)    rights of the equivalent or similar effect or nature to those in
                paragraph (i); and

        (iii)   rights under licences,  consent orders, statutes or otherwise in
                relation to a right in paragraphs (i) or (ii),

        in each case in any jurisdiction where any of the above may exist.

        "INTELLECTUAL  PROPERTY RIGHTS" means all  Intellectual  Property owned,
        used or required to be used by the Company in or in connection  with its
        business  including,  but not  limited to, the  registered  Intellectual
        Property listed in the Disclosure Letter;

        "KEY AGREEMENTS" means the Penn Pharmion  Agreement and the Penn Celgene
        Manufacturing  Agreement,  full  details  of  which  are  set out in the
        Disclosure Letter;

        "KNOW-HOW" means all designs,  specifications,  datasheets,  techniques,
        operating procedures and materials, processes, inventions,  formulations
        and formulae,  performance  data,  product and pre-clinical and clinical
        trial  data  and  records,  calculations  and  other  manufacturing  and
        technical  data and  information  which,  prior to or at the  Completion
        Date,  is owned,  used or  required  to be used by the  Company in or in
        connection with its business;

                                       4



        "LATEST ACCOUNTS" means the audited  individual  accounts of the Company
        (as defined in section 226 CA 1985) comprising  profit and loss account,
        balance sheet and directors and auditors report (and  associated  notes)
        for its financial year ended on the Latest Accounts Date, if any;

        "LATEST ACCOUNTS DATE" means 31 March 2004;

        "LATEST MANAGEMENT ACCOUNTS" means the latest management accounts of the
        Company  for the  period  commencing  on 1 April  2004 and  ending on 30
        September  2004, a true copy of which has been provided to the Purchaser
        prior to Completion;

        "LEAD INVESTOR" means  Barrington  House Nominees  Limited  Customers B,
        details of which are set out in Part 1 of Schedule 6;

        "OPTION AGREEMENT" means the option agreement entered into between Craig
        Rennie and others and  Celgene and dated 16  November  2001,  a true and
        complete copy of which is attached as annexure 6 to this Agreement;

        "PENN"  means  Penn   Pharmaceuticals   Holdings   Limited,   a  company
        incorporated in England and Wales under number 4294120, whose registered
        office  is at Units  23/24  Tafarnaubach  Industrial  Estate,  Tredegar,
        Gwent, NP2 3AA;

        "PENN  CELGENE  MANUFACTURING   AGREEMENT"  means  the  agreement  dated
        December 1995 between Penn  Pharmaceuticals  Limited (1) and Celgene (2)
        as amended and  restated  from time to time prior to the date hereof and
        any other amendments or related agreements,  a true and complete copy of
        which is attached to the Disclosure Letter;

        "PENN GROUP" means Penn, any subsidiary of Penn, any holding  company of
        Penn and any  subsidiaries  of any holding company of Penn, in each case
        for the time being,  and "MEMBER OF THE PENN GROUP"  shall be  construed
        accordingly;

        "PENN GROUP INDEBTEDNESS" means all sums or amounts due from the Company
        at the time of Completion in respect of indebtedness  for borrowed money
        to the Penn Group  together with all early  repayment  charges and other
        sums or amounts payable in respect of the repayment of such indebtedness
        upon Completion;

        "PENN PHARMION AGREEMENT" means the agreement dated 7 March 2001 between
        Pharmion  GmbH (1) and the Company (2) as amended and restated from time
        to time  (including by a subsequent  agreement  dated 16 November  2001)
        prior to the date hereof and any other amendments or related agreements,
        and a true and  complete  copy of which is  attached  to the  Disclosure
        Letter;

        "PHARMION  COMFORT  LETTER"  means the  letter to be signed by  Pharmion
        Corp. and/or Pharmion GmbH and delivered to the Purchaser on the date of
        this Agreement;

        "PHARMION  THALIDOMIDE"  means any  formulation  or  product  containing
        thalidomide  as the active  ingredient,  as distributed by Pharmion from
        time to

                                       5



        time  and  for the  time  being,  including,  without  limitation,  that
        distributed  under the Penn Pharmion  Agreement and the Celgene Pharmion
        Agreement;

        "PPL" means Penn  Pharmaceuticals  Limited,  a company  incorporated  in
        England and Wales under number 4037849,  whose  registered  office is at
        Units 23/24 Tafarnaubach Industrial Estate, Tredegar, Gwent NP2 3AA;

        "PPSL"   means  Penn   Pharmaceutical   Services   Limited,   a  company
        incorporated in England and Wales under number 1331447 whose  registered
        office  is at Units  23/24  Tafarnaubach  Industrial  Estate,  Tredegar,
        Gwent, NP2 3AA;

        "PURCHASE  PRICE" means an amount equal to the sum of  (pound)61,750,000
        less the Penn Group  Indebtedness and the RBS  Indebtedness,  subject to
        adjustment in accordance with clause 3.5;

        "PURCHASER'S ACCOUNTANTS" means KPMG LLP of 150 John F. Kennedy Parkway,
        Short Hills, NJ 07078 or such other firm of accountants as the Purchaser
        may  from  time to  time  appoint  as its  accountants  for any  purpose
        connected with this Agreement;

        "PURCHASER'S ATTORNEYS" means Proskauer Rose of 1585 Broadway, New York,
        NY 10036, USA;

        "PURCHASER'S   GROUP"  means  the  Purchaser,   any  subsidiary  of  the
        Purchaser,  any holding  company of the Purchaser and any  subsidiary of
        any holding  company of the  Purchaser,  in each case for the time being
        and "MEMBER OF THE PURCHASER'S GROUP" shall be construed accordingly;

        "PURCHASER'S  SOLICITORS" means Barlow Lyde & Gilbert of Beaufort House,
        15 St Botolph Street, London, EC3A 7NJ;

        "RBS INDEBTEDNESS" means all sums or amounts due from the Company at the
        time of  Completion  in respect of  indebtedness  for borrowed  money to
        Royal Bank of Scotland plc together with all early repayment charges and
        other sums or  amounts  payable  in  respect  of the  repayment  of such
        indebtedness upon Completion;

        "RELEVANT EARNINGS" means (pound)750,000;

        "RELEVANT  PROPORTION"  means, in relation to any Vendor, the proportion
        of the  Purchase  Price to which such  Vendor is  entitled as set out in
        part 1 of schedule 5;

        "RELIEF" has the meaning given in part 1 of schedule 3;

        "REPRESENTATIONS"  means  the  representations  set  out  in  Part  2 of
        Schedule 4;

        "RESTRICTED  PERSON"  means,  in  relation to the  covenants  set out in
        clause 7, the Warrantors;

        "RESTRICTED  PRODUCTS"  means the  thalidomide  drugs known as Thalomid,
        Sauramide and Pharmion Thalidomide;

                                       6



        "RETIRING  DIRECTORS"  has the  meaning  given  in  paragraph  2.1.3  of
        schedule 2;

        "RETIRING  SECRETARY"  has the  meaning  given  in  paragraph  2.1.4  of
        schedule 2;

        "RHC AGREEMENT" means the distributorship  agreement between the Company
        and RHC USA Corp.,  as amended and  restated  from time to time prior to
        the date hereof;

        "THE ROGER JONES INTEREST IN POSSESSION  TRUST" or "THE TRUST" means the
        interest in  possession  trust made on 30 June 1997 and  evidenced  by a
        statutory  declaration  made by Roger Spencer Jones dated 14 August 2000
        and  accompanying  exhibits  including  RSJ2 and an  undated  settlement
        executed by the said Roger Spencer Jones and Ann Jones;

        "SECONDARY   RESTRICTED  PRODUCTS"  means  any  formulation   containing
        thalidomide  or  thalidomide  analogs,   homologs  or  prodrugs  thereof
        including, without limitation, any formulation that contains thalidomide
        but excluding  the  thalidomide  drugs known as Thalomid,  Sauramide and
        Pharmion Thalidomide;

        "SECURITY  INTEREST" means any claim,  mortgage,  lien, pledge,  charge,
        encumbrance,  equity,  hypothecation,  right  of  pre-emption  or  other
        security  interest or any other  restriction or right exercisable by, or
        in favour of, any third party (or an agreement or  commitment  to create
        any of them);

        "SHARES"  means the  entire  issued  share  capital  of the  Company  at
        Completion;

        "SHARE  TRANSFERS" has the meaning given in paragraph  1.1.1 of schedule
        2;

        "STERLING"  means the lawful currency of the United Kingdom for the time
        being;

        "SUBSIDIARY"  means a subsidiary (as defined by sections 736 and 736A CA
        1985) or a subsidiary undertaking (as defined by section 258 CA 1985);

        "TAX" and "TAXATION" have the meaning given in part 1 of schedule 3;

        "TAX COVENANT" means part 2 of schedule 3;

        "TAXATION  WARRANTIES"  means  the  warranties  contained  in  part 3 of
        schedule 3;

        "TECHNICAL  SERVICES  AGREEMENT"  means the agreement in the agreed form
        pursuant  to which  Penn or a  member  of the Penn  Group  will  provide
        certain  manufacturing  and support  services  to the Company  following
        Completion;

        "TERMINATED  KEY  AGREEMENTS"  means  the  BL&H  Agreement  and  the RHC
        Agreement,  true  and  complete  copies  of  which  are  annexed  to the
        Disclosure Letter;

        "TERRITORY"  means all  territories  covered  in any and all  agreements
        entered into by (or assigned or novated to) the Company and which relate
        to  the  formulation,  storage,  supply,  sale  or  distribution  of any
        Restricted Product (including,  without limitation,  the Key Agreements)
        or any other agreement with any third party to do the same;

                                       7



        "TRANSACTION  DOCUMENTS"  means this Agreement and each of the documents
        referred  to in this  Agreement  as  being  in the  agreed  form and any
        document  from time to time entered  into  pursuant to the terms of this
        Agreement or any other such document;

        "VENDORS' ACCOUNTANTS" means PricewaterhouseCoopers LLP of One Kingsway,
        Cardiff  CF10 3PW or such  other  firm of  accountants  as the  Vendors'
        Representatives  on behalf of the Vendors may from time to time  appoint
        as their accountants for any purpose connected with this Agreement;

        "VENDORS'  REPRESENTATIVE"  means Craig  Rennie or such other  person(s)
        (being a Vendor) that the Vendors  acting  jointly may from time to time
        nominate in writing to the Purchaser;

        "VENDORS'  SOLICITORS" means Addleshaw Goddard of 100 Barbirolli Square,
        Manchester M2 3AB;

        "WARRANTIES"  means  the  warranties  set  out in  clause  6,  Part 1 of
        Schedule 4, the Taxation Warranties and the warranties and covenants set
        out in Schedule 10;

        "WARRANTORS"  means the persons  whose names and addresses are stated in
        part 2 of schedule 6; and

        "WARRANTORS'  REPRESENTATIVE"  means Craig  Rennie or such other  person
        (being a Warrantor) that the Warrantors  acting jointly may from time to
        time nominate in writing to the Purchaser.

1.2     Terms Defined Elsewhere in this Agreement
        -----------------------------------------

        In addition to the terms defined in clause 1.1,  certain other terms are
        defined  elsewhere in this Agreement  (denoted by  capitalised  words in
        quotes and bold type).  Each such term shall have the meaning stated for
        the  purpose  of the  provision  in which  it is  defined  and,  if used
        elsewhere in this Agreement, where so used, unless the context otherwise
        requires.

1.3     Interpretation of words and expressions used in this Agreement
        --------------------------------------------------------------

        In this Agreement, unless the context otherwise requires:

        1.3.1   a document expressed to be "IN THE AGREED FORM" means a document
                in a form which has been  agreed by or on behalf of the  Parties
                at or before the execution of this  Agreement and which has, for
                the purposes of  identification,  been signed or  initialled  by
                them or on their behalf;

        1.3.2   references to a clause, schedule or annexure are to a clause of,
                or a schedule  or  annexure  to,  this  Agreement  respectively;
                references to this Agreement include its schedules and annexures
                and  references  in  a  schedule  or  part  of a  schedule  to a
                paragraph  are to a paragraph  of that  schedule or that part of
                that schedule respectively; further, the schedules and annexures
                form part of this Agreement,  shall be deemed to be incorporated
                in this  Agreement  and shall be read as though  set out in this
                Agreement in full;

                                       8



        1.3.3   references  to this  Agreement  or any other  document or to any
                specified  provision of this Agreement or any other document are
                to this  Agreement,  that document or that provision as in force
                for  the  time  being  and as  amended  from  time  to  time  in
                accordance with the terms of this Agreement or that document, as
                the case may be;

        1.3.4   references  to any English  legal term for any  action,  remedy,
                method of judicial  proceeding,  legal  document,  legal status,
                Court,  official or any legal concept or thing shall, in respect
                of any  jurisdiction  other than England and Wales, be deemed to
                include what most nearly  approximates  in that  jurisdiction to
                the English legal term;

        1.3.5   words importing the singular  include the plural and vice versa,
                words  importing a gender include every gender and references to
                a  "PERSON"   include   any   individual,   corporation,   firm,
                partnership,   joint  venture,  association,  body  of  persons,
                organisation  or  trust  (in each  case  whether  or not  having
                separate legal personality);

        1.3.6   words and phrases which are  generally  defined for the purposes
                of CA 1985 shall bear the  meanings  attributed  to them by that
                Act as at the date of this Agreement;

        1.3.7   a person shall be deemed to be "ASSOCIATED  WITH" another person
                or an "ASSOCIATED PERSON" of that other person if such person is
                an associate  of the other person  within the meaning of section
                435 Insolvency Act 1986;

        1.3.8   the  word  "COMPANY",  except  where  used in  reference  to the
                Company,  shall be  deemed to  include  any  corporation,  firm,
                partnership,  joint venture, association,  organisation or other
                body of persons,  whether  incorporated or not  incorporated and
                whether  now  existing  or to be  formed  after the date of this
                Agreement; and

        1.3.9   without prejudice to the right of assignment conferred by clause
                9.11.3,  nothing in this  Agreement  shall  confer any rights or
                obligations  on any person who has not executed  this  Agreement
                (or such  person's  successors or assigns) nor shall the consent
                of any person who has not so executed  this  Agreement  (or such
                person's   successors   or   assigns)  be  needed  to  make  any
                modification,  amendment,  variation  or  release  of the  terms
                hereof and the Parties  expressly  agree for the purposes of the
                Contracts  (Rights of Third  Parties)  Act 1999 that they do not
                intend any person  other than a Party to this  Agreement  or any
                assignee of the Purchaser permitted pursuant to clause 9.11.3 to
                be able to enforce any term of this Agreement.

                                       9



1.4     Contents table and headings
        ---------------------------

        In this Agreement,  the contents table and the descriptive  headings to,
        and  within,   clauses,   schedules  and  paragraphs  are  inserted  for
        convenience  only,  have no legal  effect  and shall be  ignored  in the
        interpretation and construction of this Agreement.

1.5     References to statutory provisions
        ----------------------------------

        In this Agreement, unless the context otherwise requires,  references to
        statutory  provisions or subordinate  legislation (as defined by section
        21(1) Interpretation Act 1978) shall be construed as references to those
        provisions or that  subordinate  legislation as  respectively  replaced,
        amended  or  re-enacted  (whether  before  or  after  the  date  of this
        Agreement)  from  time to time  and  shall  include  any  provisions  or
        subordinate legislation of which they are re-enactments (whether with or
        without  modification)  and any subordinate  legislation made under such
        provisions  save to the extent  that such  replacements,  amendments  or
        re-enactments  taking  effect  after  the date of this  Agreement  would
        impose any greater  obligations or liabilities on, or reduce the benefit
        to, any Party.

2       SALE AND PURCHASE

2.1     Each  Vendor  shall sell with full title  guarantee,  and the  Purchaser
        shall  purchase,  those  Shares set  opposite  his/its name in Part 1 of
        Schedule 6 with effect from Completion  free from any Security  Interest
        and together  with all rights and benefits  attaching to them  including
        all dividends declared or paid in relation to the Shares on or after the
        date of this Agreement.

2.2     Each of the  Vendors  waives  any  pre-emption  rights  over the  Shares
        whether  conferred  by the  articles  of  association  of the Company or
        otherwise.

2.3     Each of the Vendors severally  warrants,  in relation to himself/itself,
        to each other Party that:

        2.3.1   he or it  has  the  requisite  power  and  authority  under  its
                constitutional documents (if relevant) and otherwise to execute,
                deliver and perform his/its obligations under this Agreement and
                any other Transaction Document to be executed by him/it;

        2.3.2   in the  case  of any  Vendor  which  is a  body  corporate,  the
                execution   and  delivery  of,  and  the   performance   of  its
                obligations   under  this   Agreement  and  each  of  the  other
                Transaction  Documents  to be  executed  by it  have  been  duly
                authorised by all necessary corporate action on its part whether
                under its memorandum and articles of association or otherwise;

        2.3.3   other than pursuant to the Option Agreement there is not (nor is
                there  pending or  applicable)  any  option,  right to  acquire,
                mortgage,  charge,  pledge,  lien or other form of  security  or
                encumbrance  on, over or affecting  any of the Shares to be sold
                by him/it, there is no agreement or commitment to give or create
                any of the foregoing, and so far as he/it is

                                       10



                aware,  no person has either made or is likely to make any claim
                to be entitled to any of the foregoing;

        2.3.4   he or it will, at Completion,  be entitled and empowered to sell
                and  transfer,  or procure  the sale and  transfer  of, the full
                legal and  beneficial  ownership  in those  Shares to be sold by
                him/it on the terms set out in this Agreement; and

        2.3.5   this Agreement constitutes,  and the other Transaction Documents
                executed  or to be  executed  by  him/it  will,  when  executed,
                constitute  legal,  valid  and  binding  obligations  of  him/it
                enforceable in accordance with their respective terms.

2.4     Each of Celgene and the  Purchaser  severally  warrants,  in relation to
        itself, to each Vendor that:

        2.4.1   it  has  the   requisite   power   and   authority   under   its
                constitutional  documents and otherwise to execute,  deliver and
                perform  its  obligations  under  this  Agreement  and any other
                Transaction Document to be executed by it; and

        2.4.2   the  execution  and  delivery  of,  and the  performance  of the
                obligations  of it under  this  Agreement  and each of the other
                Transaction Documents have been duly authorised by all necessary
                corporate  action on its part whether  under its  constitutional
                documents or otherwise.

3       CONSIDERATION

3.1     Consideration
        -------------

        The  consideration  for the sale and purchase of the Shares shall be the
        Purchase Price, payable in accordance with this clause 3.

3.2     Apportionment of the Purchase Price between the Vendors
        -------------------------------------------------------

        The  Purchase  Price,  including  any  further  amount  payable  by  the
        Purchaser  pursuant  to clause  3.6,  shall be  apportioned  between the
        Vendors as follows:

        3.2.1   by the  payment  of an amount  equal to the  accrued  but unpaid
                preferential dividend to the Lead Investor;

        3.2.2   by  the  payment  of any  preferential  amounts  payable  to the
                holders of the A Preference  Shares and the B Preference  Shares
                in the capital of the Company; and

        3.2.3   by the  payment of any  balance to the  Vendors in the  Relevant
                Proportions.

3.3     Payment on account at Completion
        --------------------------------

        On  Completion,  the  Purchaser  shall pay the  Initial  Payment  to the
        Vendors in cash in Sterling on account of the Purchase  Price,  of which
        (pound)48,317,533.69 shall

                                       11



        be paid to the Vendors in accordance  with the  provisions of clause 8.1
        and the balance,  being the Escrow  Amount,  shall be paid in accordance
        with the provisions of clause 3.4.

3.4     Payment of Escrow Amount
        ------------------------

        On Completion, the Purchaser shall pay the Escrow Amount into the Escrow
        Account out of the  consideration to be received by the Warrantors.  The
        Escrow  Amount shall be dealt with in  accordance  with the terms of the
        Escrow Deed.

3.5     Determination of the Purchase Price and Completion Accounts
        -----------------------------------------------------------

        3.5.1   Immediately following Completion,  the Parties shall comply with
                their  respective  obligations  pursuant  to the  provisions  of
                Schedule 7.

        3.5.2   The Purchase  Price is subject to adjustment in accordance  with
                this clause  3.5.  There shall be added on a (pound) for (pound)
                basis the amount by which the  Closing  Net  Financial  Position
                less the Relevant  Earnings exceeds zero or, as the case may be,
                there  shall be  deducted  on a (pound)  for  (pound)  basis the
                amount by which the  Closing  Net  Financial  Position  less the
                Relevant Earnings is less than zero.

3.6     Adjustments following determination of the Purchase Price
        ---------------------------------------------------------

        If the Purchase Price, as finally agreed or determined  pursuant to this
        Agreement:

        3.6.1   is less than  (pound)51,117,533.69,  each Vendor  shall repay to
                the  Purchaser  his/its   proportiOn  of  the  shortfall,   such
                proportion  being determined by reference to the amount received
                by such Vendor of the  amounts  paid in  accordance  with clause
                3.3;

        3.6.2   is greater than (pound)51,117,533.69, the Purchaser shall pay to
                each Vendor his/its RelEvant Proportion of the excess; or

        3.6.3   is equal to (pound)51,117,533.69,  no balancing payment shall be
                made pursuant to this clause.

3.7     Payment of amounts under clause 3.6
        -----------------------------------

        Any amount  payable  pursuant to clause  3.6.1 or clause  3.6.2 shall be
        paid in cash (in Sterling) within 10 Business Days of final agreement or
        determination  of the  Purchase  Price in  accordance  with  Schedule 7.
        Interest shall be payable on any amounts due pursuant to clause 3.6.1 or
        3.6.2 at a rate per annum of one per cent. above the base rate from time
        to time of  Barclays  Bank plc for the  entire  period  from the date of
        Completion until the date on which such amount is paid in full. Interest
        shall accrue and be payable from day to day.

                                       12



4       COMPLETION

4.1     Location and time
        -----------------

        Completion  shall take place at the offices of the  Vendors'  Solicitors
        (or at such other place as the Vendors'  Representatives on the one part
        and  the  Purchaser  on  the  other  may  agree)  immediately  following
        execution of this Agreement when the Parties shall comply with all (but,
        subject to clause 4.2 and to clause 4.3,  not part) of their  respective
        obligations as set out in schedule 2. The Purchaser shall not be obliged
        to complete the purchase of any of the Shares unless the purchase of all
        the Shares is completed simultaneously.

4.2     If Completion does not take place on the Completion Date because of any
        -----------------------------------------------------------------------
        of the Vendors
        --------------

        If any of the  Vendors  shall  fail or be unable  to comply  with any of
        his/its obligations as set out in schedule 2 on the Completion Date, the
        Purchaser may (but without  prejudice to the  Purchaser's  rights or any
        remedy or action the Purchaser may have (whether under this Agreement or
        otherwise) in respect of such failure or inability to comply):

        4.2.1   defer Completion to a date not more than 10 Business Days (or as
                mutually  agreed  in  writing  between  the  Purchaser  and  the
                Vendors'  Representative  on behalf of the  Vendors)  after that
                date (in which  case the  provisions  of this  clause  4.2 shall
                apply to  Completion  as so deferred and the  provisions of this
                Agreement  shall apply as if that other date is the date set for
                Completion in clause 4.1); or

        4.2.2   proceed to Completion so far as practicable; or

        4.2.3   terminate this Agreement.

4.3     If Completion does not take place on the Completion Date because of the
        -----------------------------------------------------------------------
        Purchaser
        ---------

        If the  Purchaser  shall  fail or be unable  to  comply  with any of its
        obligations  as set out in clause 3.3 or in schedule 2 on the Completion
        Date,  the  Vendors'  Representatives  may on behalf of the Vendors (but
        without  prejudice  to the  Vendors'  rights or any remedy or action the
        Vendors may have (whether  under this Agreement or otherwise) in respect
        of such failure or inability to comply):

        4.3.1   defer Completion to a date not more than 10 Business Days (or as
                mutually  agreed  in  writing  between  the  Purchaser  and  the
                Vendors'  Representatives  on behalf of the Vendors)  after that
                date (in which  case the  provisions  of this  clause  4.3 shall
                apply to  Completion  as so deferred and the  provisions of this
                Agreement  shall apply as if that other date is the date set out
                for Completion in clause 4.1); or

        4.3.2   proceed to Completion so far as practicable; or

        4.3.3   terminate this Agreement.

                                       13



5       POST-COMPLETION MATTERS

5.1     Dealings in the Sale Shares pending registration of transfers
        -------------------------------------------------------------

        Each  Vendor  hereby  declares  that,  for so long as he/it  remains the
        registered holder of any of the Shares after Completion, he/it will:

        5.1.1   hold such Shares and any  dividends and other  distributions  of
                profits  or surplus or other  assets  declared,  paid or made in
                respect of them after  Completion  and all rights arising out of
                or in  connection  with them in trust for the  Purchaser and its
                successors in title or assignees; and

        5.1.2   deal with and  dispose  of the  Shares  and all such  dividends,
                distributions  and rights as are  described in clause 5.1.1 only
                as the Purchaser or any such successor or assignee may direct in
                writing.

5.2     Name and Logo
        -------------

        5.2.1   Notwithstanding  any other provision of this  Agreement,  if the
                Company owns or uses the names  "Penn"  and/or any other name or
                any  of  the  logos  disclosed  in the  Disclosure  Letter  with
                specific  reference  to this  clause  5.2,  or any  name or mark
                confusingly  similar to any of them  including  any name or mark
                which  incorporates the name "Penn" and/or the logos referred to
                above (or any name or mark confusingly  similar to any of them),
                the Purchaser  shall,  and shall procure that the Company shall,
                on the  Completion  Date or as soon  as  reasonably  practicable
                thereafter  (and save as provided in the licence  referred to in
                Clause  5.2.2  below),  cease to use any  such  name or mark and
                shall within 7 days following a request to do so by the Vendors'
                Representative  procure that the Company  shall  assign,  as the
                Vendors'  Reprsesentative  may  direct,  free  of  any  Security
                Interest,  all rights of the Company in any such name or mark by
                way of an assignment in a form which is reasonably  satisfactory
                to the Vendors' Representatives.

        5.2.2   If, at  Completion,  the Company uses any names or logos as part
                of  its  business  under  any  licences  or  other  arrangements
                (written or unwritten) with any companies in the Penn Group, the
                Vendors  shall  procure  that  the  Company  is  granted  by the
                relevant  company in the Penn Group  (insofar as that company is
                legally able) a royalty-free,  non-exclusive licence in terms to
                be agreed by the  parties to continue to use such names or logos
                for a period  of 12  months  after  Completion  (or such  longer
                period  as  mutually  agreed in  writing  between  the  Vendors'
                Representative, Penn and the Purchaser).

6       WARRANTIES AND REPRESENTATIONS

6.1     The  Warrantors,  upon the  execution  of this  Agreement,  jointly  and
        severally  warrant to the Purchaser in the terms of the  Warranties  and
        represent  to the  Purchaser  in the terms of the  Representations.  The
        Representations  have been  given with the  intention  of  inducing  the
        Purchaser to enter into this Agreement.

                                       14



6.2     The  Warranties  and  Representations  shall  continue in full force and
        effect notwithstanding Completion.

6.3     Disclosure Letter
        -----------------

        The Warranties and  Representations  are given subject only to any fact,
        matter or circumstance to the extent the same is fairly disclosed in the
        Disclosure Letter.

6.4     Independence of Warranties and Representations
        ----------------------------------------------

        Each of the  Warranties  and the  Representations  shall be separate and
        independent and save where this Agreement provides otherwise,  shall not
        be limited by reference to any other warranty, indemnity, representation
        or any other provision of this Agreement.

6.5     Waiver of claim(s) by any Warrantor against the Company's directors or
        ----------------------------------------------------------------------
        employees, agents and advisers
        ------------------------------

        Each Warrantor  agrees with the Purchaser (for itself and as trustee for
        the Company and the  directors,  employees,  agents and  advisers of the
        Company):

        6.5.1   that the  giving by the  Company  and/or  any of its  directors,
                employees,  agents or advisers of any  information or opinion in
                connection with the  Warranties,  the  Representations,  the Tax
                Covenant or the  Disclosure  Letter or  otherwise in relation to
                the business or affairs of the Company or in connection with the
                negotiation  and  preparation  of this  Agreement  or any  other
                Transaction Document shall not be deemed to be a representation,
                warranty or guarantee to the  Warrantors  of the accuracy of any
                such information or opinion;

        6.5.2   to waive any right or claim  which  he/it may have  against  the
                Company  and/or  any  of  its  directors,  employees  agents  or
                advisers  for any error,  omission or  misrepresentation  in any
                such information or opinion or any action taken on or before the
                Completion Date; and

        6.5.3   that any such right or claim shall not  constitute  a defence to
                any  claim  by  the  Purchaser  under  or in  relation  to  this
                Agreement or any other Transaction Document.

6.6     General provisions in relation to the Warranties etc
        ----------------------------------------------------

        6.6.1   Subject to clause 9.6 (Entire  Agreement) which shall, in so far
                as is possible and legally enforceable,  prevail, the rights and
                remedies  conferred  on  any  Party  under  this  Agreement  are
                cumulative  and are  additional  to, and not  exclusive  of, any
                rights or remedies provided by law or otherwise available at any
                time to that Party in  respect  of any breach of this  Agreement
                (including the right to damages for any loss or additional  loss
                suffered by that Party).

        6.6.2   Any  payment   made  in  respect  of  any  of  the   Warranties,
                Representations  or under the Tax Covenant  shall, to the extent
                possible, be deemed to be an adjustment in the Purchase Price.

                                       15



        6.6.3   Neither the Warranties,  the Representations,  nor any rights or
                remedies   in  respect  of  them,   shall  in  any   respect  be
                extinguished or affected by Completion.

        6.6.4   Where any Warranty or  Representation is limited by reference to
                the knowledge,  awareness or belief of any person, such Warranty
                or  Representation  shall be deemed  to refer to the  knowledge,
                awareness  or belief of the relevant  Warrantor  having made all
                reasonable  enquiry of the following persons only in relation to
                such Warranty or Representation, as the case may be:

                (i)     Craig Robert Rennie;
                (ii)    David Greig Henderson;
                (iii)   Paul Spencer Thomas;
                (iv)    Keren Winmill; and
                (v)     Steve Evans.

                Where any Warranty or  Representation is so limited by reference
                to the  knowledge,  awareness  or belief of any person,  for the
                avoidance  of  doubt no  Warrantor  shall  be  required  to make
                enquiry  of  any  other  person  in  giving  such   Warranty  or
                Representation.

        6.6.5   For the  avoidance  of  doubt,  in no  circumstances  shall  the
                Warranties or  Representations be given or deemed to be given to
                any extent by the Lead Investor.

6.7     Subsequent Disposal
        -------------------

        If the Purchaser makes a disposal (the "DISPOSAL") of some or all of the
        Shares or some or all of the undertaking in the Company to a third party
        purchaser (the "THIRD PARTY  Purchaser") and as a term of such Disposal,
        the  Purchaser  provides  warranties  to the Third  Party  Purchaser  in
        relation to the Company and the  operation of the Business  prior to the
        Completion Date and in so doing relies on the Warranties then,  provided
        always that the Vendors  shall have no greater  liability  to either the
        Purchaser  or (if  applicable)  the Third  Party  Purchaser  under or in
        respect  of a breach of this  Agreement  than they would have had to the
        Purchaser  under the Agreement in respect of such breach if the Disposal
        had not been made and the Purchaser had not so relied on the Warranties,
        the Vendors  acknowledge  and agree that their  liability  for any claim
        that the Purchaser  would have had, but for the  Disposal,  shall not be
        extinguished, reduced or limited solely by reason of the Disposal.

6.8     Taxation
        --------

        The provisions of schedule 3 shall be incorporated into this Agreement.

6.9     Trustees
        --------

        As trustees  of the Roger Jones  Interest  in  Possession  Trust,  Roger
        Spencer Jones and Ann Jones  jointly and severally  warrant and covenant
        to the Purchaser in the terms set out in schedule 10.

                                       16



7       RESTRICTIVE COVENANTS IN FAVOUR OF THE PURCHASER

7.1     Restrictive Covenants
        ---------------------

        Each  Restricted  Person  undertakes with the Purchaser that without the
        prior  consent in writing of the  Purchaser,  he will not,  directly  or
        indirectly,  whether by himself,  his employees or agents and whether on
        his own behalf or on behalf of any other person, firm or company,  for a
        period of five years from the date of Completion:

        RESTRICTED PRODUCTS

        7.1.1   (subject  to clause  7.3)  carry on, be  employed  or  otherwise
                engaged,  concerned  or  interested  in, any  business  which is
                engaged  in  (or   arranges   with  any  third  party  for)  the
                manufacture, procurement of manufacture, distribution or sale of
                the  Restricted  Products  or any of  them in the  Territory  (a
                "COMPETING BUSINESS");

        7.1.2   (subject  to  clause  7.3)  in  relation  to  the   manufacture,
                production,  distribution or sale of Restricted  Products or any
                of them in the Territory, solicit or canvass, accept orders from
                or  otherwise  deal  with any  person,  firm,  company  or other
                organisation  who was a  customer  of the  Company,  at any time
                during  the 12  months  prior to  Completion  and with whom that
                Restricted Person had personal dealings;

        7.1.3   solicit or entice away or  endeavour to solicit or entice way or
                hire from the Company,  any person employed or otherwise engaged
                by the  same in the  manufacture,  procurement  of  manufacture,
                distribution  or sale of the Restricted  Products or any of them
                in the  Territory,  whether or not that person  would commit any
                breach of his  contract of  employment  by reason of his leaving
                the service of the same;

        SECONDARY RESTRICTED PRODUCTS

        7.1.4   (subject  to clause  7.3)  carry on, be  employed  or  otherwise
                engaged,  concerned  or  interested  in, any  business  which is
                engaged  in  (or   arranges   with  any  third  party  for)  the
                manufacture, procurement of manufacture, distribution or sale of
                the  Secondary  Restricted  Products  or  any  of  them  in  the
                Territory (a "SECONDARY COMPETING BUSINESS");

        7.1.5   (subject  to  clause  7.3)  in  relation  to  the   manufacture,
                production,   distribution  or  sale  of  Secondary   Restricted
                Products  or any of them in the  Territory,  solicit or canvass,
                accept  orders from or  otherwise  deal with any  person,  firm,
                company or other organisation who was a customer of the Company,
                at any time during the 12 months  prior to  Completion  and with
                whom that Restricted Person had personal dealings;

        7.1.6   solicit or entice away or  endeavour to solicit or entice way or
                hire from the Company,  any person employed or otherwise engaged
                by the  same in the  manufacture,  procurement  of  manufacture,
                distribution or sale of the Secondary Restricted Products or any
                of them in the Territory, whether


                                       17



        or not that person would commit any breach of his contract of employment
        by reason of his leaving the service of the same.

7.2     Subject  to clause  7.3,  each  Restricted  Person  undertakes  with the
        Purchaser  that he will not at any time  after  Completion  directly  or
        indirectly,  whether by himself,  his  employees  or agents or otherwise
        howsoever:

        7.2.1   in the  course  of  carrying  on any trade or  business,  claim,
                represent or otherwise indicate any present association with the
                Company; or

        7.2.2   use,  whether on his own behalf or on behalf of any third party,
                or  disclose  any  of  the  Confidential  Information.

7.3     The restrictions in clause 7.1 and 7.2 shall not operate to prohibit any
        Restricted  Person  from  holding in  aggregate  up to 3 per cent of the
        shares of any  company  operating  a  Competing  Business or a Secondary
        Competing  Business (as the case may be), the shares of which are listed
        or dealt in on a recognised  stock exchange or from being or becoming an
        employee,  director,  shareholder  or  consultant  of Penn or any  other
        member of the Penn Group and performing his duties as such.

7.4     The restriction in clause 7.2.2 shall not apply:

        7.4.1   in respect of any of the Confidential Information which is in or
                becomes part of the public domain other than through a breach of
                the  obligations  of  confidentiality,  whether  set out in this
                Agreement or otherwise; or

        7.4.2   to the extent that  disclosure of  Confidential  Information  is
                required by any  applicable  law,  governmental  order,  decree,
                regulation,  licence or rule or pursuant to the  regulations  of
                any securities exchange or regulatory or governmental body.

7.5     Each of the undertakings  contained in clauses 7.1 and 7.2 is a separate
        undertaking  by each  Restricted  Person in  relation to himself and his
        interests  and shall be  enforceable  by the  Purchaser  separately  and
        independently  of its  right  to  enforce  any one or more of the  other
        covenants  contained in clauses 7.1 and 7.2. If a covenant is held to be
        illegal,   invalid  or  unenforceable  but  would  be  legal,  valid  or
        enforceable  if  some  part  were  deleted  or the  period  or  area  of
        application were reduced or modified, then the covenant shall apply with
        such  modification  as may be  necessary  to make it  legal,  valid  and
        enforceable.

8       PAYMENTS

8.1     Payments to the Vendors
        -----------------------

        Any  amounts  payable  to the  Vendors or any of them  pursuant  to this
        Agreement (or the Escrow Deed), including for the avoidance of doubt any
        payments to be made  pursuant to clause 3.6,  may be paid in Sterling by
        telegraphic transfer to the following account of the Vendors' Solicitors
        (or such other account of the Vendors'  Solicitors as may be notified to
        the  Purchaser  in  writing  by the  Vendors'  Representatives  for this
        purpose from time to time):

                                       18



        -------------------------------- ---------------------------------------
        Account Name:                    Addleshaw Goddard Client Account
        -------------------------------- ---------------------------------------
        Name of bank:                    The Royal Bank of Scotland plc
        -------------------------------- ---------------------------------------
        Bank address and postcode:       St Ann Street
                                         Manchester
                                         M60 2SS
        -------------------------------- ---------------------------------------
        Sort code:                       16-00-02
        -------------------------------- ---------------------------------------
        Account number:                  11122897
        -------------------------------- ---------------------------------------


8.2     Vendors' Solicitors authorised to receive payments
        --------------------------------------------------

        The Vendors' Solicitors are hereby irrevocably authorised by the Vendors
        and each of them so to receive  any such  amount and receipt of any such
        amount in such an account or the receipt of the Vendors'  Solicitors for
        any such amount shall be good,  valid and  effectual  discharge  for the
        Purchaser respect of such amount.

8.3     Allocation of payments between Vendors
        --------------------------------------

        Provided  that the  Purchaser  shall have duly complied with its payment
        obligations  wherever  expressed in this Agreement,  the Purchaser shall
        have no  obligation  relating to the  distribution  of any such  payment
        between the Vendors or any of them (including,  without limitation,  the
        apportionment pursuant to clause 3.2).

8.4     Payments to the Purchaser
        -------------------------

        Any amounts payable to the Purchaser pursuant to this Agreement shall be
        paid by telegraphic  transfer to the following  account of the Purchaser
        (or such other  account in the United  Kingdom of the  Purchaser (or its
        nominee) as may be notified to the Vendors'  Representatives  in writing
        by the Purchaser for this purpose from time to time):

        -------------------------------- ---------------------------------------
        Account name:                    Celgene Corporation Operating Account
        -------------------------------- ---------------------------------------
        Name of bank:                    PNC Bank, Pittsburgh PA
        -------------------------------- ---------------------------------------
        Account number:                  8100 901 961
        -------------------------------- ---------------------------------------
        ABA#:                            031 207 607

        -------------------------------- ---------------------------------------
        Swift code:                      PNCCUS33
        -------------------------------- ---------------------------------------


9       GENERAL

9.1     Continuing effect of this Agreement
        -----------------------------------

        All  provisions  of this  Agreement and any other  Transaction  Document
        shall,  so far as they are  capable  of  being  performed  or  observed,
        continue in full force and effect notwithstanding Completion,  except in
        respect of those matters then already performed and Completion shall not
        constitute  a waiver of any of the  Parties'  rights in relation to this
        Agreement or any other Transaction Document.

                                       19



9.2     Announcements
        -------------

        Save as (but  only to the  extent)  required  by law or by any  relevant
        national    or     supra-national     regulatory,     governmental    or
        quasi-governmental  body or authority,  all  announcements  by, of or on
        behalf of any of the  Parties  relating  to the  subject  matter of this
        Agreement or the transaction  contemplated by this Agreement shall be in
        terms to be agreed between the Parties in advance of issue.

9.3     Releases and waivers
        --------------------

        9.3.1   Any  Party  may,  in its  discretion,  in whole  or in part,  in
                writing, release, compound, compromise, vary, amend, abrogate or
                waive its rights or grant time or  indulgence in respect of, any
                liability  or  obligation  to it  under  this  Agreement  or any
                Transaction Document and may do so as regards any one or more of
                the other  Parties in respect of that  obligation  or  liability
                without in any way prejudicing or affecting the liability of, or
                its rights against, any other of the other Parties in respect of
                the same or a like obligation or liability.

        9.3.2   Neither the single or partial  exercise or  temporary or partial
                waiver by any Party of any right,  nor the  failure by any Party
                to  exercise  in whole or in part any  right or to insist on the
                strict  performance  of any  provision of this  Agreement or any
                other Transaction Document, nor the discontinuance,  abandonment
                or adverse  determination of any proceedings  taken by any Party
                to enforce any right or any such provision shall (except for the
                period or to the extent covered by any such temporary or partial
                waiver)  operate as a waiver of, or  preclude  any  exercise  or
                enforcement or (as the case may be) further or other exercise or
                enforcement  by that  Party  of,  that  or any  other  right  or
                provision.

        9.3.3   All references in clause 9.3.2 to:

                (a)     any  right  shall  include  any  power,  right or remedy
                        conferred  by this  Agreement  or any other  Transaction
                        Document on, or provided by law or  otherwise  available
                        to, any Party; and

                (b)     any failure to do something  shall  include any delay in
                        doing it.

        9.3.4   The  giving by any Party of any  consent to any act which by the
                terms  of  this  Agreement  or any  other  Transaction  Document
                requires  such  consent  shall not  prejudice  the right of that
                Party to  withhold  or give  consent to the doing of any similar
                act.

9.4     Notices
        -------

        LANGUAGE OF NOTICES

        9.4.1   Any notice or other  document to be given  under this  Agreement
                shall be in writing in the English language.

                                       20



        ADDRESSES AND FAX NUMBERS FOR NOTICES

        9.4.2   Notice details for the Parties are as follows:

                ---------------- ------------------------------ ----------------
                PARTY                 ADDRESS AND FAX NUMBER    ADDRESSEE/MARKED
                                                                FOR THE
                                                                ATTENTION OF
                ---------------- ------------------------------ ----------------
                The Vendors      c/o Penn Pharmaceuticals       Craig Rennie
                or the Vendors'  Services Limited
                Representative   Units 23 and 24
                                 Tafarnaubach Industrial Estate
                                 Tredegar
                                 Gwent
                                 Fax: 0044 1495 713 616
                ---------------- ------------------------------ ----------------
                The Purchaser    Celgene Corporation            Sol Barer
                or Celgene       7 Powder Horn Drive
                Corporation      Warren
                                 NJ 07059
                                 Fax: 001 732 271 4184
                                 (Copy to
                                 (i)   Vice President
                                       Legal and Chief
                                       Counsel
                                       Fax: 001 732 805 3697
                                 (ii)  the Purchasers'
                                       Solicitors
                                       (ref: John Cadman)
                                       Fax: 0044 207 071 9000)
                                 (iii) Proskauer Rose (ref:
                                       Robert A. Cantone)
                                       Fax: 001 212 969 2900
                ---------------- ------------------------------ ----------------


        A Party may change its notice details for the purpose of this clause 9.4
        to any other  address in the United  Kingdom by giving notice to all the
        Parties to this Agreement in accordance with this clause 9.4.

        PROOF OF NOTICE BEING PROPERLY GIVEN

        9.4.3   In  proving  the  giving  of a  notice,  it shall be  conclusive
                evidence to prove:

                (a)     if  delivered  by hand,  that the notice was left at the
                        appropriate address specified in clause 9.4.2;

                (b)     if sent by  post,  that  the  envelope  containing  such
                        notice  was  properly  addressed  and  posted (by way of
                        courier  in the case of notice  being sent from or to an
                        address outside the United Kingdom); or

                                       21



                (c)     if sent  by  fax,  that a fax  transmission  report  was
                        obtained by the sender  confirming the fax  transmission
                        to the relevant number stated in clause 9.4.2.

        WHEN NOTICES ARE TO BE DEEMED RECEIVED

        9.4.4   If a notice is:

                (a)     delivered  by  hand  between  9.00  am and  5.00 pm on a
                        Business Day (such time period being referred to in this
                        clause 9.4.4 as within  "BUSINESS  HOURS"),  it shall be
                        deemed  received  when so delivered  or, if delivered by
                        hand outside Business Hours, it shall be deemed received
                        at 9.00 am on the next  Business  Day  after the time of
                        delivery;

                (b)     sent by post:

                        (i)     if the notice was posted on a Business  Day,  it
                                shall  be  deemed  received  at  9.00  am on the
                                fourth Business Day (second  Business Day in the
                                case of  courier)  after  the  day the  envelope
                                containing such notice was posted; or

                        (ii)    if the notice was not posted on a Business  Day,
                                it shall be  deemed  received  at 9.00 am on the
                                fourth Business Day (second  Business Day in the
                                case of  courier)  after  the day on  which  the
                                envelope containing such notice was posted; or

                (c)     sent by fax during  Business  Hours,  it shall be deemed
                        received  when so  delivered  or, if sent by fax outside
                        Business  Hours,  it shall be deemed received at 9.00 am
                        on the next Business Day after the time that the fax was
                        sent to the relevant number stated in clause 9.4.2.

        9.4.5   Any reference in this clause 9.4 to a particular time is to that
                time in the location of the recipient of the relevant notice.

9.5     Time
        ----

        9.5.1   Time shall be of the essence for the purposes of this  Agreement
                as regards any time,  date or period fixed by this Agreement for
                the  performance of any obligation by any of the Parties to this
                Agreement,  whether  as  originally  fixed or as  altered in any
                manner provided in this Agreement.

        9.5.2   Save where stated  otherwise in clause 9.5,  all  references  to
                time in this Agreement are to London time.

9.6     Entire Agreement
        ----------------

        9.6.1   This  Agreement  (together  with  all of the  other  Transaction
                Documents)  sets  out the  entire  agreement  and  understanding
                between the Vendors on

                                       22



                the one part and the Purchaser on the other in  connection  with
                the sale and purchase of the Shares and other matters  described
                therein.

        9.6.2   Each of the Parties  acknowledges  that it is not relying on any
                statements,  warranties or representations  given or made by any
                of the  Parties  in  relation  to the  subject  matter  of  this
                Agreement,  save for those  expressly set out in this  Agreement
                and the other  Transaction  Documents  and that it shall have no
                rights or remedies with respect to such subject matter otherwise
                than  under  this  Agreement  and any of the  other  Transaction
                Documents,  but  provided  that this  clause  shall not  exclude
                liability  for  fraud,   wilful   non-disclosure  or  fraudulent
                misrepresentation.

9.7     Alterations
        -----------

        Without  prejudice  to the  provisions  of  clause  9.3.1  no  purported
        alteration of this Agreement shall be effective unless it is in writing,
        refers  specifically  to  this  Agreement  and is duly  executed  by all
        Parties to this Agreement.

9.8     Severability
        ------------

        Each  provision of this  Agreement is  severable  and distinct  from the
        others. The Parties intend that every such provision shall be and remain
        valid and  enforceable  to the fullest  extent  permitted by law. If any
        such provision is or at any time becomes to any extent invalid,  illegal
        or  unenforceable  under any  enactment or rule of law, it shall to that
        extent be deemed not to form part of this  Agreement but (except to that
        extent in the case of that  provision)  it and all other  provisions  of
        this  Agreement  shall  continue  in full  force  and  effect  and their
        validity,  legality and enforceability  shall not be thereby affected or
        impaired.

9.9     Counterparts
        ------------

        This  Agreement  may be  entered  into  in  the  form  of  two  or  more
        counterparts,  each  executed by one or more of the Parties  but,  taken
        together,  executed by all and,  provided  that all the Parties so enter
        into  this  Agreement,  each of the  executed  counterparts,  when  duly
        exchanged and delivered,  shall be deemed to be an original,  but, taken
        together, they shall constitute one instrument.

9.10    Payment of costs
        ----------------

        Each of the Parties shall be responsible  for his/its  respective  legal
        and other costs and  expenses  incurred in relation to the  negotiation,
        preparation   and   completion  of  this  Agreement  and  all  ancillary
        documents.  For the  avoidance  of doubt,  it is agreed that the Company
        shall not be  responsible  for any of the costs  incurred in relation to
        any such matters.

9.11    Successors and Assigns
        ----------------------

        9.11.1  This  Agreement  shall be binding  on,  and shall  enure for the
                benefit of, the  successors  in title and (where  relevant)  the
                personal representatives and estate of each Party.

                                       23



        9.11.2  Save as  contemplated  by clause  9.11.3  none of the Parties to
                this  Agreement  may be  entitled  to assign the  benefit of any
                rights under this Agreement.

        9.11.3  The  benefit of this  Agreement  may be  assigned in whole or in
                part at any  time  by the  Purchaser  to any  one or more  third
                parties  (including,  without  limitation,  any  member  of  the
                Purchaser's Group, any Celgene Affiliate or any successor of the
                Purchaser).

                The Vendors  shall have no greater  liability  to an assignee of
                the  Purchaser  under,  or  in  respect  of a  breach  of,  this
                Agreement  than they would have had to the  Purchaser  under the
                Agreement  in respect of such breach if the  assignment  had not
                been made.

                In this respect it is  acknowledged  by the Vendors that, in the
                event that the Purchaser either assigns this Agreement, in whole
                or in part, in accordance with the provisions of this Agreement,
                or directs  that  Shares be  transferred  directly to such third
                parties  (pursuant  to  paragraph  1.1.1  of  Schedule  2),  the
                Purchaser may receive  payment in respect of such  assignment or
                transfer,  which  payment  may be greater  than or less than the
                appropriate  proportion of the Purchase Price. For the avoidance
                of doubt,  such payment to the Purchaser  shall not give rise to
                any  obligation  of the  Purchaser  to make any  payment  to the
                Vendors over and above the Purchase  Price due to the Vendors in
                accordance with the terms of this Agreement.

        9.11.4  If the  benefit  of this  Agreement  is  assigned  or  otherwise
                transferred  to a third  party in  accordance  with this  clause
                9.11, the relevant Party or the personal representatives of such
                Party shall give written  notice of such  assignment or transfer
                to the other Parties as soon as reasonably practicable.

9.12    Full amounts payable
        --------------------

        All  amounts  payable  under  this  Agreement  shall  be  paid  in  full
        notwithstanding any rights of set-off, counterclaim or similar rights.

10      CHOICE OF LAW, SUBMISSION TO JURISDICTION AND SERVICE OF PROCESS

10.1    Choice of Law
        -------------

        10.1.1  This Agreement  shall be governed by and construed in accordance
                with  English  law,  and all claims  and  disputes  between  the
                Parties or any of them arising out of or in connection with this
                Agreement  (whether  or not  contractual  in  nature)  shall  be
                determined in accordance with English law.

        10.1.2  If in any court any party  argues  that a court  other  than the
                Courts of England and Wales has  jurisdiction  to determine  any
                dispute or difference between the Parties or any of them arising
                out of or in connection  with this Agreement that issue shall be
                determined in

                                       24



        accordance  with English  law,  and any right any Party might  otherwise
        have to rely  upon  the law of the  forum  or any  other  law is  hereby
        irrevocably and unconditionally waived.

10.2    Submission to jurisdiction
        --------------------------

        10.2.1  Each Party submits to the exclusive  jurisdiction  of the Courts
                of  England  and  Wales in  relation  to all  claims,  disputes,
                differences  or other  matters  arising out of or in  connection
                with this Agreement.

        10.2.2  Each Party irrevocably waives any right that it may have:

                (a)     to object on any  ground to an action  being  brought in
                        the  Courts of  England  and  Wales,  to claim  that the
                        action  brought in the  Courts of England  and Wales has
                        been brought in an inconvenient  forum, or to claim that
                        the   Courts   of   England   and   Wales  do  not  have
                        jurisdiction.   The  waiver  contained  in  this  clause
                        10.2.2(a) includes (without  limitation) a waiver of all
                        formal and  substantive  requirements  of any  otherwise
                        competent   jurisdiction  in  relation  to  this  clause
                        10.2.2(a);

                (b)     to oppose the  enforcement  of any judgment of any court
                        of England and Wales  whether on any ground  referred to
                        in clause 10.2.2(a) or otherwise.

10.3    Service of process
        ------------------

        10.3.1  Each Party agrees that, without prejudice to the validity of any
                other mode of service, any document in an action (including, but
                not  limited  to, any claim  form,  application  notice or other
                originating  process)  may be  served  on  any  party  by  being
                delivered  to or left for that party at its  address for service
                of notices under clause 9.4.

        10.3.2  Notwithstanding  and  without  prejudice  to the  foregoing  the
                Purchaser and the Guarantor  appoint the Purchaser's  Solicitors
                as its agent to  receive  service  of  process in respect of any
                proceedings commenced in the Courts of England and Wales arising
                out of or in connection with this Agreement.

        10.3.3  Without  prejudice to the  effectiveness  of service pursuant to
                any other  method  recognised  by the Rules of Civil  Procedure,
                service of such process upon the Purchaser's Solicitors at their
                address  given  in  this  Agreement  or  elsewhere   within  the
                jurisdiction  of the Courts of England and Wales pursuant to the
                Rules  of Civil  Procedure  for the  time  being in force  shall
                constitute good service on the Purchaser.  The Purchaser and the
                Guarantor   undertake  not  to  contest  in  any  court  in  any
                jurisdiction  the  enforcement  in  that   jurisdiction  of  any
                judgment  of the Courts of England  and Wales  against it on the
                ground  that  the  Courts  of  England  and  Wales  did not have
                jurisdiction  over it or that service of process  (being service
                in accordance  with this clause) was invalid or  ineffective  or
                resulted  in it  not  having  due  or  adequate  notice  of  the
                proceedings.

                                       25



11      TERMINATION

        If at any time on or before Completion,  the Purchaser exercises its, or
        the Vendors  exercise  their,  right of termination  under clause 4.2 or
        clause 4.3  (Completion),  each Party's  further rights and  obligations
        under  this  Agreement  shall  cease   immediately  on  termination  but
        termination shall not affect a party's accrued rights and obligations at
        the date of termination and the provisions of clauses 1 (Definitions), 9
        (General), 10 (Choice of Law), 12 (Option Agreement), 13 (Appointment of
        Vendors' Representatives and Warrantors' Representative) and 15 (Celgene
        Guarantee) shall remain in full force and effect.

12      OPTION AGREEMENT: CONFLICT AND SURVIVAL

        In the event of any conflict  between the  provisions of this  Agreement
        and the  provisions  of the Option  Agreement,  the  provisions  of this
        Agreement shall prevail.

13      VENDORS' REPRESENTATIVES AND WARRANTORS' REPRESENTATIVE

13.1    Subject to the  provisions  of clause 13.2 and save in respect of clause
        7, the Vendors' Representatives shall represent the interests of Vendors
        for all  purposes  of this  Agreement  and  the  Transaction  Documents.
        Without giving notice to Vendors, the Vendors' Representative shall have
        full and irrevocable  authority as duly appointed  attorney on behalf of
        the Vendors (a) to deal with the other parties to this  Agreement or the
        Transaction  Documents,  (b)  to  accept  and  give  notices  and  other
        communications  relating to this Agreement or the Transaction Documents,
        (c) to settle any dispute relating to the terms of this Agreement or the
        Transaction Documents,  (d) to waive any condition to the obligations of
        Vendors found in this  Agreement or the  Transaction  Documents,  (e) to
        modify or amend this Agreement or the Transaction  Documents except with
        respect to the  Purchase  Price to be  received by the  Vendors,  (f) to
        execute any instrument or document that the Vendors' Representatives may
        determine is  necessary or desirable in the exercise of their  authority
        under this clause 13, (g) to  transfer  Shares in  accordance  with this
        Agreement and (h) to act in connection  with all matters arising out of,
        based upon,  or in  connection  with this  Agreement or the  Transaction
        Documents and the transactions contemplated hereby or thereby.

13.2    The Warrantors' Representative shall exclusively represent the interests
        of the  Warrantors  for the purposes of clause 6, schedule 3, schedule 4
        and schedule 7 of this Agreement and for the purposes of the Escrow Deed
        and   the   Escrow   Account   Instruction   Letter.   The   Warrantors'
        Representative  shall  have  full  and  irrevocable  authority,  to  the
        exclusion of the Vendors' Representatives, as duly appointed attorney on
        behalf of the  Warrantors,  to do all things  which are  referred  to in
        clause 13.1(a) to (g)  inclusive,  to the extent that the same relate to
        any of the  provisions  of this  Agreement  referred to above and/or the
        provisions of the Escrow Deed.

                                       26



14      PENN SHARES - RIGHT OF FIRST REFUSAL AND LAST REFUSAL

        The Vendors hereby  severally  undertake to the Purchaser and Celgene in
        the terms set out in schedule 8.

15      CELGENE GUARANTEE

        Celgene  hereby  undertakes  to  guarantee  certain  obligations  of the
        Purchaser in the terms set out in schedule 9.

IN WITNESS  whereof this  Agreement has been executed and delivered as a deed on
the date specified above.

                                       27



                                   SCHEDULE 1

                                   The Company
                                   -----------

1    Date and place of incorporation:   16th August 2001

2    Registered number:                 4272045

3    Registered office:                 Units  23-24   Tafarnaubach   Industrial
                                        Estate, Tredegar, Gwent NP22 3AA

4    Authorised share capital:          (pound)119,405.30 divided into 275,000 A
                                        ordinary shares of 0.2p each,  225,000 B
                                        ordinary shares of 2p each,  5,479,000 A
                                        preference shares of 2p each and 238,765
                                        B preference shares of 2p each

5    Issued share capital:              275,000 A ordinary shares all fully paid

                                        225,000 B ordinary shares all fully paid

                                        2,739,500 A preference shares

                                        198,971 B preference shares

6    Shareholders:                      the issued share  capital is held at the
                                        date of this  Agreement  as  detailed in
                                        column 3 of part 1 of schedule 6

7    Directors:                         Jeremy Richard Granville Hyde
                                        Simon Nicholas Inchley
                                        Craig Robert Rennie
                                        Paul Spencer Thomas
                                        Ken Caldicott
                                        Keren Winmill
                                        David Henderson
                                        Christopher Higgins
                                        Steve Evans

8    Secretary:                         David Henderson

9    Auditors:                          PricewaterhouseCoopers LLP

10   Bankers:                           Royal Bank of Scotland

11   Accounting reference date:         31st March

12   Outstanding mortgages or charges:  N/A

                                       28



                                   SCHEDULE 2

                               Completion Matters
                               ------------------

1       DOCUMENTS AND OTHER ITEMS TO BE DELIVERED BY THE VENDORS

1.1     There shall be delivered to the Purchaser at Completion:

        The Shares
        ----------

        1.1.1   by each  Vendor,  transfers  in respect  of the  Shares  held by
                him/it  (together  the  "SHARE  TRANSFERS")  duly  executed  and
                completed  in favour of the  Purchaser  or any one or more third
                parties  (including,   without  limitation,   any  affiliate  of
                Celgene)  as the  Purchaser  may,  by notice in  writing  to the
                Vendors' Representative, direct:

        1.1.2   by each Vendor, share certificates for the Shares held by him/it
                or an indemnity in respect of any lost share  certificate in the
                agreed form; and

        1.1.3   by each Vendor,  a certified copy of any duly executed powers of
                attorney  pursuant to which any of the Share Transfers  relating
                to shares held by him/it has been executed;

        Statutory records and minute books
        ----------------------------------

        1.1.4   by the Warrantors, as agents for the Company:

                (a)     all its statutory and minute books;

                (b)     its common seal (if any);

                (c)     its  certificate of  incorporation,  any  certificate or
                        certificates of incorporation on change of name; and

                (d)     copies of its memorandum and articles of association.

        Directors' and secretary's resignations
        ---------------------------------------

        1.1.5   by  the  Warrantors,   written   resignations  of  the  Retiring
                Directors  (other than any  appointed by any Lead  Investor) and
                the  Retiring  Secretary  in the  agreed  form  resigning  their
                respective offices and waiving any claims whatsoever against the
                Company;

        1.1.6   by any  Lead  Investor,  written  resignations  of the  Retiring
                Directors  appointed  by that Lead  Investor  in the agreed form
                resigning  their  respective  offices  and  waiving  any  claims
                whatsoever against the Company;

        Powers of Attorney
        ------------------

        1.1.7   by each  Vendor,  a power of  attorney  in the agreed  form duly
                executed by that Vendor appointing the Purchaser

                                       29



                and any  director  of the  Purchaser  for the time being for the
                purpose  of  exercising  voting and other  rights and  receiving
                benefits and entitlements which attach to or arise in respect of
                any of the Shares  held by him/it and  receiving  notices of and
                attending  and  voting at all  meetings  of the  members  of the
                Company  (or any  class  thereof)  and  generally  executing  or
                approving  such  deeds or  documents  and doing any such acts or
                things in  relation to any of such  Shares as the  attorney  may
                think fit.

        Other Documents
        ---------------

        1.1.8   by each Vendor,  a duly executed  release of all claims which it
                may have against the Company in the agreed form;

        1.1.9   by each  Vendor,  a duly  executed  counterpart  of the  Deed of
                Termination;

        1.1.10  by each  Warrantor,  a duly executed  counterpart  of the Escrow
                Deed;

        1.1.11  by Penn,  PPSL and the Company,  a duly executed  counterpart of
                the Technical Services Agreement;

        1.1.12  by each Warrantor, a duly executed counterpart of the Disclosure
                Letter;

        1.1.13  by Royal Bank of Scotland  plc and  others,  the Deed of Release
                and Consent, duly executed and dated;

        1.1.14  by Royal Bank of Scotland  plc, a completion  statement  setting
                out the amount  required  (including  any  charges  and  accrued
                interest) to repay the RBS Indebtedness;

        1.1.15  by Penn, a completion  statement setting out the amount required
                (including  any charges and accrued  interest) to repay the Penn
                Group  Indebtedness  and  confirmation  that the Company owes no
                other amounts to any member of the Penn Group;

        1.1.16  by  the  Vendors,   duly  executed   copies  of  the  agreements
                terminating the Terminated Key Agreements;

        1.1.17  by  the  Vendors,  a duly  executed  counterpart  of the  Escrow
                Account Instruction Letter; and

        1.1.18  by the  Vendors,  written  confirmation  of the  inception  from
                Completion of (a) the run-off  insurance  cover in favour of the
                Company on such terms as have been agreed  between the Purchaser
                and the Vendors and (b) the other  insurance  policies that Penn
                is  obliged  to take  out  pursuant  to the  Technical  Services
                Agreement.

2       OBLIGATIONS OF THE VENDORS

        Company Board Meeting
        ---------------------

2.1     The Vendors shall procure that a duly convened and quorate board meeting
        of the Company is held at which:

                                       30



        REGISTRATION OF THE SHARE TRANSFERS

        2.1.1   the Share Transfers are resolved to be registered  (subject only
                to their being duly  stamped)  notwithstanding  any provision to
                the contrary in the articles of association of the Company;

        APPOINTMENTS AND RESIGNATIONS OF DIRECTOR(S) AND SECRETARY

        2.1.2   such persons as the Purchaser may nominate are validly appointed
                as additional directors of the Company;

        2.1.3   on the  appointments  referred to in paragraph 2.1.2 being made,
                all other then current  directors of the Company ("THE  RETIRING
                DIRECTORS") cease to be directors of the Company;

        2.1.4   such person as the Purchaser  may nominate is validly  appointed
                as  secretary  of the  Company  in  place  of the  then  current
                secretary ("THE RETIRING SECRETARY").

        AUDITORS

        2.1.5   the  Auditors  shall  resign  their  office as  auditors  of the
                Company by depositing their written notice of resignation in the
                agreed form at its registered  office in accordance with section
                392 CA 1985 along with a statement under section 394 of that Act
                that there are no circumstances  connected with their ceasing to
                hold  office  which  they  consider  should  be  brought  to the
                attention of the members or creditors of the Company;

        APPROVAL OF TECHNICAL SERVICE AGREEMENT

        2.1.6   the Company's  entering into the Technical Services Agreement is
                approved.

        Repayment of Vendor indebtedness
        --------------------------------

2.2     Each Vendor shall repay to the Company,  or procure the repayment to the
        Company of, all indebtedness outstanding at Completion from:

        2.2.1   that Vendor;

        2.2.2   any person associated with that Vendor,

        (other than any  indebtedness  in respect of any trading in the ordinary
        course  of  business  by the  Company  to the  extent  the same has been
        disclosed in the  Disclosure  Letter which shall be repaid in accordance
        with then existing arrangements in the normal course).

                                       31



3       OBLIGATIONS OF THE PURCHASER

3.1     The Purchaser shall:

        Payment of Initial Payment
        --------------------------

        3.1.1   pay the Initial  Payment  less the Escrow  Amount by  electronic
                funds  transfer for value on the day of Completion in accordance
                with the provisions of clause 8;

        Payment of Escrow Amount
        ------------------------

        3.1.2   pay the Escrow Amount by electronic  funds transfer for value on
                the day of Completion into the Escrow Account;

        Disclosure Letter
        -----------------

        3.1.3   deliver  to  the  Vendors'   Solicitors  the  Disclosure  Letter
                counter-signed by the Purchaser;

        Repayment of Indebtedness
        -------------------------

        3.1.4   immediately following  Completion,  procure the repayment by the
                Company of the Penn Group Indebtedness and the RBS Indebtedness;

        Deed of Termination
        -------------------

        3.1.5   deliver to the Vendors'  Solicitors a duly executed  counterpart
                of the Deed of Termination;

        Escrow Deed
        -----------

        3.1.6   deliver to the Vendors'  Solicitors a duly executed  counterpart
                of the Escrow Deed;

        Technical Services Agreement
        ----------------------------

        3.1.7   deliver to the Vendors'  Solicitors a duly executed  counterpart
                of the Technical Services Agreement; and

        Escrow Account Instruction Letter
        ---------------------------------

        3.1.8   deliver to the Vendors'  Solicitors a counterpart  of the Escrow
                Account  Instruction  Letter  duly  executed  by Celgene and the
                Purchaser.

4       JOINT OBLIGATIONS OF THE PURCHASER AND THE VENDORS

4.1     The Purchaser and the Vendors shall join in procuring that:

        4.1.1   such firm as the  Purchaser  shall  nominate  shall be appointed
                auditors of the Company in place of the Auditors;

                                       32



        4.1.2   all  existing  bank  mandates in force for the Company  shall be
                altered (in such  manner as the  Purchaser  shall at  Completion
                require) to reflect the resignations  and appointments  referred
                to in paragraph 2.1;

        4.1.3   the current accounting  reference period of the Company shall be
                altered so as to end on such date as the Purchaser may require;

        4.1.4   the  registered  office of the Company  shall be changed to such
                place as the Purchaser may require; and

        4.1.5   there  shall  be  passed a  special  resolution  of the  Company
                changing its name to one not  including  the word "Penn",  which
                the  Purchaser  shall  then  procure  is filed at the  Companies
                Registry as soon as practicable.

                                       33



                                   SCHEDULE 3

                                       Tax
                                       ---

                                Part 1 - General
                                ----------------

1       INTERPRETATION

1.1     In this schedule (unless the context otherwise requires):

        "ACCOUNTS RELIEF" means any Relief to the extent to which it is shown as
        an  asset  in the  Completion  Accounts  or is  taken  into  account  in
        computing  (and so reducing or  eliminating)  any provision for deferred
        Taxation which appears,  or which but for the presumed  availability  of
        the Relief would have appeared, in the Completion Accounts;

        "ACTUAL TAXATION  LIABILITY" means a liability to make an actual payment
        of  Taxation  whether  or not  such  Taxation  is also or  alternatively
        chargeable against or attributable to any other person;

        "CAA" means the Capital Allowances Act 2001;

        "CLAIM" means:

        (a)     any  notice,  demand,  assessment,   including  self-assessment,
                determination,  letter or other document  issued or action taken
                by or on behalf of a Tax Authority; or

        (b)     any other  circumstance  in  relation  to the  operation  of the
                corporation  tax pay and file or corporation tax self assessment
                regimes  concerning the running of the Company's Tax affairs and
                whether  issued  or  taken  before  or  after  the  date of this
                Agreement  and  whether  satisfied  or not at the  date  of this
                Agreement); or

        (c)     any return, amended return,  computation,  accounts or any other
                documents required for the purposes of Taxation,

        in each case, indicating that:

        (i)     the  Company  has  suffered or incurred or may suffer or incur a
                Taxation Liability; or

        (ii)    the  Company  will be  required  to make  increased  or  further
                payments to a Taxation Authority; or

        (iii)   any of the assets of the Company or the Purchaser (including any
                shares  in the  Company)  are  subject  to any  power  of  sale,
                mortgage  or  charge  resulting  from or in  consequence  of any
                liability to inheritance tax;

                                       34



        "DEEMED TAXATION LIABILITY" means:

        (a)     the setting off of a  Post-Completion  Relief  against an Actual
                Taxation  Liability  of the  Company  in  respect  of which  the
                Warrantors would have been liable under paragraph 1.1.1 or 1.1.2
                of part 2 or (as the case may be)  against  income,  profits  or
                gains  which  would have  given rise to such an Actual  Taxation
                Liability (a "Set Off Liability"),  in which event the amount of
                the Set Off  Liability  is in the former  case the amount of the
                Actual Taxation Liability  eliminated by such setting off and in
                the latter case the amount of the Actual  Taxation  Liability of
                the Company which would have arisen but for such setting off;

        (b)     the  unavailability  of an Accounts  Relief in consequence of an
                Event  occurring  on or  before  Completion  in which  event the
                amount of the Deemed Taxation Liability is:

                (i)     where the  Accounts  Relief  unavailable  is a deduction
                        from or  set-off  against  either  Taxation  or  income,
                        profits or gains (an  "Unavailable  Relief  Liability"),
                        the amount of the earliest Actual Taxation  Liability of
                        the  Company  to arise  which  would not have  arisen or
                        could have been avoided but for such unavailability; and

                (ii)    where the Accounts  Relief  unavailable  is a right to a
                        repayment   of  Taxation  (an   "Unavailable   Repayment
                        Liability"),  the amount of  Taxation  which  would have
                        been repaid but for such unavailability;

        "EVENT"  means any  event,  transaction,  act,  occurrence,  dealing  or
        omission whatsoever, including the death of any person, the execution of
        the Agreement,  Completion, the acquisition,  disposal or realisation of
        any asset;

        "GROUP  RELIEF" has the meaning given to that  expression by section 402
        ICTA;

        "IHTA" means the Inheritance Tax Act 1984;

        "INDEPENDENT  EXPERT"  means a  member  of the  Chartered  Institute  of
        Taxation or the Institute of Chartered  Accountants in England and Wales
        independent of the Parties who has had a specialised  Taxation  practice
        for at least ten years and who shall be appointed  by agreement  between
        the  relevant  Parties or  (failing  such  agreement  and upon the first
        application  made by any such party) by the  President of the  Chartered
        Institute  of Taxation or the  Institute  of  Chartered  Accountants  in
        England and Wales;

        "POST-COMPLETION  RELIEF"  means  any  Relief  which  arises  wholly  in
        consequence of or by reference to an Event  occurring or deemed to occur
        after  Completion and not in consequence of or by reference to any Event
        occurring  or  deemed to occur on or before  Completion  (but  shall not
        include any Relief referred to in paragraph 4.2);

        "RELIEF"  means  any loss,  allowance,  exemption,  set-off,  deduction,
        credit  or other  relief  from any  Taxation  or in the  computation  of
        income,  profits or gains for the purpose of any  Taxation and any right
        to a repayment of Taxation;

                                       35



        "TAX or TAXATION" means:

        (a)     any  form of tax,  and any  levy,  duty,  impost,  deduction  or
                withholding  of any  kind,  in each  case in the  nature of tax,
                whether  governmental,   statutory,  state,  provincial,  local,
                governmental  or  municipal  whenever  created  or  imposed  and
                whether of the  United  Kingdom,  part of the United  Kingdom or
                elsewhere (but not including,  water rates,  community charge or
                council  tax or any  tax,  charge,  rate  or  duty  similar  to,
                corresponding with, replacing or replaced by any of them) and

        (b)     all charges, surcharges,  interest, penalties and fines relating
                to any Taxation falling within paragraph (a) of this definition;

        and  regardless  of  whether  such  taxes,   duties,   levies   charges,
        contributions,  imposts, deductions or withholdings, interest, penalties
        or fines are chargeable  directly or primarily  against or  attributable
        directly or  primarily to the Company or any other person and of whether
        any  amount  in  respect  of any of them is  recoverable  from any other
        person;

        "TAXATION  AUTHORITY"  means any  authority  or  person,  whether of the
        United  Kingdom,  part of the  United  Kingdom or  elsewhere,  imposing,
        assessing or collecting any Taxation;

        "TAXATION  LIABILITY"  means any Actual Taxation  Liability,  any Deemed
        Taxation  Liability  and any costs,  fees and  expenses  falling  within
        paragraph 1.1.5 of part 2;

        "TAX REFUND" means a tax refund relating to an accounting  period within
        the meaning of section 102 FA 1989;

        "TCGA" means the Taxation of Chargeable Gains Act 1992;

        "UNAVAILABILITY"  means,  in  relation  to an amount  of a  Relief,  the
        reduction,  modification,  claw-back,  counteraction,   disallowance  or
        cancellation of or failure to obtain that amount of that Relief but does
        not include the  set-off of any Relief  against  Taxation or any income,
        profits or gains and "UNAVAILABLE" shall be construed accordingly; and

        "VATA" means the Value Added Tax Act 1994.

        "VENDOR'S  RELIEF" means any Relief which is or becomes available to the
        Company, other than an Accounts Relief or a Post-Completion Relief;

1.2     In this schedule (unless the context otherwise requires):

        1.2.1   references  to  persons  include  an  individual,   corporation,
                partnership,  unincorporated association, or body of persons and
                any state or any agency thereof;

        1.2.2   references to parts are references to parts of this schedule and
                reference  in any part to a paragraph  shall,  unless  otherwise
                stated, be to the paragraph of that part.

                                       36



1.3     Any  payments  made  pursuant  to this  schedule  or for  breach  of any
        Warranty shall,  so far as possible,  be treated as an adjustment to the
        consideration paid by the Purchaser for the Shares under this Agreement.

1.4     References to "income, profits or gains", earned, accrued or received on
        or before a particular date or in respect of a particular period include
        income,  profits  or gains  which are  deemed  for the  purposes  of the
        Taxation  in  question  to have been  earned,  accrued or received at or
        before that date or in respect of that period;

1.5     References to a payment or  distribution  made on or before a particular
        date shall include:

        (a)     any  payment  or  distribution  which  for the  purposes  of the
                Taxation in question is treated as having been made on or before
                that date; and

        (b)     any act or transaction which has occurred on or before that date
                and is or has been  deemed to be a payment or  distribution  for
                the purposes of any Taxation assessment.

1.6     The  rule  known  as the  ejusdem  generis  rule  shall  not  apply  and
        accordingly  general  words  introduced by the word "other" shall not be
        given a restrictive meaning by reason of the fact that they are preceded
        by words indicating a particular class of acts, matters or things; and

1.7     General words shall not be given a restrictive  meaning by reason of the
        fact  that they are  followed  by  particular  examples  intended  to be
        embraced by the general words.

2       EXCLUSIONS AND LIMITATIONS

2.1     The Warrantors  shall not be liable for breach of any Taxation  Warranty
        in respect of any Taxation  Liability  (or where the loss,  liability or
        damage  arising in  consequence  of a breach of any Tax  Warranty is any
        Taxation Liability) or under part 2 in respect of any Taxation Liability
        to the extent that:

        2.1.1   provision or reserve for it is made in the  Completion  Accounts
                or payment or discharge of it is taken into account therein;

        2.1.2   any  Vendor's  Relief  is  or  becomes  available  (or  is  made
                available  at no cost to the  Company) to mitigate  the Taxation
                Liability  or breach  (and  where  the  Warrantors  request  the
                Purchaser  to utilise a Vendor's  Relief  the  Warrantors  shall
                indemnify   the   Purchaser   for  any   material   third  party
                professional costs incurred by the Purchaser in using a Vendor's
                Relief);

        2.1.3   it  arises in  consequence  of, or would  have been  reduced  or
                eliminated but for:

                (a)     any  voluntary  act or  omission  of the  Company or any
                        member  of  the  Purchaser's  Group  carried  out  after
                        Completion  which the Company or the relevant  member of
                        the Purchaser's  Group knew or ought  reasonably to have
                        known would give rise to the

                                       37



                        relevant Taxation Liability provided that this exclusion
                        shall not apply:

                        (i)     if the act or  omission  was  carried out by the
                                Company in the  ordinary  course of  business of
                                the Company; or

                        (ii)    if the  Company  carried out the act or omission
                                to  comply  with  a  binding  legal   commitment
                                created on or before  Completion or with any law
                                or court order or direction or regulation having
                                the  force  of law in  each  case  in  force  at
                                Completion  or  to  ensure  that  the  Company's
                                accounts  complied with any  generally  accepted
                                accounting  practices or standards applicable as
                                at Completion; or

                (b)     the  combined  effect  of  any  Event  occurring  before
                        Completion  and any  Event  occurring  after  Completion
                        except where the Event  occurring  before  Completion is
                        outside the  ordinary  course of business of the Company
                        and the Event occurring  after  Completion is within the
                        ordinary course of business of the Company;

                (c)     the  Company  ceasing to carry on any trade or  business
                        after  Completion  or  effecting  a major  change  after
                        Completion  in the  nature  or  conduct  of any trade or
                        businesses carried on by it at Completion (in each case,
                        within the meaning of section 768, ICTA);

                (d)     the Company  changing  the date to which it makes up its
                        statutory  accounts  or changing  any of its  accounting
                        policies (including,  without limitation,  the treatment
                        of timing differences and the bases on which the Company
                        values  its  assets)  in either  case  after  Completion
                        except to the extent that such changes are  necessary to
                        ensure  that  such   accounting   policies  comply  with
                        generally  accepted  accounting  practices and standards
                        applicable as at Completion;

                (e)     the  Company  disposing  of any capital  asset  acquired
                        after  Completion,  or ceasing after  Completion to be a
                        member of a group for the purposes of any Taxation;

                (f)     the failure by the Company after  Completion to make any
                        claim, election,  surrender or disclaimer or to give any
                        notice or consent or to do any other thing,  the making,
                        giving or doing of which was  permitted by law and which
                        is taken in to account:

                        (i)     in computing and so reducing any provision which
                                appears   in   the   Completion   Accounts   (or
                                eliminating  any provision which would otherwise
                                have appeared in the Completion Accounts);

                                       38



                        (ii)    in computing  any right to repayment of Taxation
                                which appears in the Completion Accounts;

                        and which was properly disclosed to the Purchaser in the
                        Disclosure  Letter  or the  making,  giving  or doing of
                        which is notified by the  Warrantors to the Purchaser at
                        least 5 Business  Days' prior to the  expiration  of the
                        time  limit  to  make  such   election,   surrender   or
                        disclaimer or the withdrawal or amendment by the Company
                        after Completion of any such claim, election, surrender,
                        disclaimer,  notice  or  consent  validly  made  by  the
                        Company prior to Completion;

                (g)     any  failure by the  Purchaser  or the Company to comply
                        with its  obligations  under  paragraph 6 ("Appeals  and
                        conduct  of   claims")   or   paragraph   8   ("Taxation
                        Computations");

                (h)     any  legislation  or  any  change  in  the  rate  of any
                        Taxation or any  imposition of Taxation or change in the
                        published   practice,   published   interpretations   or
                        concessions  of any  Taxation  Authority  in  each  case
                        coming into effect after Completion;

                (i)     the Company  ceasing to be subject to corporation tax at
                        the small  companies'  rate (or  qualifying  for  relief
                        under  section  13(2)  ICTA)  and  becoming  subject  to
                        corporation  tax at the  rate  applicable  to  companies
                        generally  as a result of the sale and  purchase  of the
                        Company on the terms of this Agreement;

        2.1.4   the Purchaser  has  recovered  damages or any other amount under
                this  Agreement  (whether  for  breach of  warranty,  under this
                schedule or otherwise)  in respect of the same loss,  liability,
                or  damage  or the  Purchaser  or  the  Company  have  otherwise
                obtained reimbursement or restitution from the Warrantors.

3       MITIGATION OF LIABILITY

3.1     The Warrantors may, in particular but without  limitation,  by notice in
        writing  to the  Purchaser  avoid or  reduce  any  liability  which  the
        Warrantors  would,  apart from this  paragraph 3.1, have under part 2 or
        for breach of any Taxation  Warranty by procuring  the  surrender to the
        Company  of  Group  Relief,  advance  corporation  tax  or a Tax  Refund
        (without the  Purchaser or the Company  being liable to make any payment
        in consideration for such surrender) and the liability of the Warrantors
        under part 2 or for  breach of any  Taxation  Warranty  shall be validly
        satisfied  or avoided to the extent of the amount of Taxation  which has
        been  validly  satisfied or avoided as a result of such  surrender.  The
        Purchaser  shall  procure  that the Company  takes all such steps (at no
        cost to the Company),  including (without  limitation) making and giving
        all such claims and consents as the Warrantors may reasonably request to
        effect any such surrender.

                                       39



4       OVER-PROVISIONS AND RELIEFS

4.1     The  Purchaser  shall at the request of the  Warrantors  (or the Vendors
        Representative  on behalf of the  Warrantors)  require  the  Auditors to
        determine (as experts and not as  arbitrators  and at the expense of the
        Warrantors) whether:

        4.1.1   any provision for Taxation in the Completion Accounts has proved
                to be an over-provision and if so its amount;

        4.1.2   any right to a repayment of Taxation  treated as an asset in the
                Completion  Accounts has proved to be understated  and if so its
                amount or,  where no right to  repayment of Taxation was treated
                as an asset in the Completion Accounts,  whether any such amount
                should have been treated as an asset in the Completion  Accounts
                the Closing Balance Sheet and if so the amount; or

        4.1.3   any Actual  Taxation  Liability  which arises or would otherwise
                have arisen  (other than one which  would  otherwise  have given
                rise  to a  corresponding  liability  of  the  Warrantors  under
                paragraph 1 of part 2) is avoided or reduced or any repayment of
                an amount of Taxation is obtained in either case by the use of a
                Vendor's Relief,  and, if so, the amount of Taxation so saved or
                the amount of that repayment; and

        if  the  Auditors  determine  that  there  has  proved  to be  any  such
        over-provision,   understatement   or   amount,   the   amount  of  such
        over-provision,  understatement  or amount (as the case may be) shall be
        dealt with in accordance with paragraph 4.3.

4.2     The Purchaser  shall at the request of the  Warrantors  (or the Vendors'
        Representative  on behalf of the  Warrantors)  require  the  Auditors to
        determine (as experts and not as  arbitrators  and at the expense of the
        Warrantors)  whether any Taxation Liability (or the Event giving rise to
        such  Taxation  Liability or the  discharge of it) which has resulted in
        any sum having been paid or  becoming  payable by the  Warrantors  under
        part 2 or for breach of any Taxation Warranty has given rise to a Relief
        (or would give rise to a Relief  assuming that all reasonable  steps are
        taken to obtain such Relief) which would not otherwise have arisen, and:

        4.2.1   a  liability  of the  Company  to  make  an  actual  payment  or
                increased  payment of Taxation has been  satisfied or avoided in
                whole or in part by the use of that Relief; or

        4.2.2   a right to a repayment of Taxation has arisen as a result of the
                use of that Relief;

        and, if the Auditors so  determine,  the amount by which that  liability
        has been  satisfied  or avoided or an amount equal to the amount of that
        repayment  (as the case may be) shall be dealt with in  accordance  with
        paragraph  4.3 (for the  avoidance  of doubt  this  shall  not avoid the
        Warrantors making a payment in respect of any Taxation  Liability if the
        determination by the Auditors has not been completed or the Relief as so
        determined  by the Auditors is not available

                                       40



        by the time of the due date for payment by the  Warrantors  under part 2
        in respect of such Taxation Liability).

4.3     Where it is provided under paragraph 4.1 or 4.2 that any amount is to be
        dealt with in accordance with this paragraph 4.3:

        4.3.1   the amount  shall first be set off against any payment  then due
                from the  Warrantors  under part 2 or for breach of any Taxation
                Warranty;

        4.3.2   to the extent there is an excess,  a refund shall be made to the
                Warrantors,   within   5   business   days   of  the   auditor's
                determination  referred to in  paragraph  4.1,  of any  previous
                payment made by the Warrantors under part 2 or for breach of any
                Taxation Warranty and not previously  refunded under this clause
                up to the amount of such excess; and

        4.3.3   to the extent that the excess  referred to in paragraph 4.3.1 is
                not exhausted thereunder,  the remainder of that excess shall be
                carried  forward and set off against  any future  payment  which
                becomes  due from the  Warrantors  under part 2 or for breach of
                any Taxation Warranty.

4.4     Where such  determination  by the  Auditors as is mentioned in paragraph
        4.1 or 4.2 has been made, the Warrantors (or the Vendors' Representative
        on behalf of the  Warrantors)  or the Purchaser may request the Auditors
        to review such  determination  (at the expense of the person  making the
        request) in the light of all relevant circumstances, including any facts
        which have become known only since such determination,  and to determine
        whether such determination  remains correct or whether,  in the light of
        those   circumstances,   the  amount   that  was  the  subject  of  such
        determination should be amended.

4.5     If the Auditors  determine under paragraph 4.4 that an amount previously
        determined  should be amended,  that amended amount shall be substituted
        for the purposes of  paragraph  4.1 or 4.2, as the case may be, in place
        of the amount originally  determined and such adjusting payment (if any)
        as may be required by virtue of such  substitution  shall  forthwith  be
        made by the  Warrantors  to the Purchaser or, as the case may be, by the
        Purchaser to the Warrantors.

5       RECOVERY FROM THIRD PARTIES

        If, in the event of any payment  becoming due from the Warrantors  under
        part 2 or for breach of any Taxation  Warranty and the Company either is
        immediately  entitled at the due date for the making of that  payment to
        recover  from some  other  person  any sum in  respect  of the  Taxation
        Liability  that  has  resulted  in that  payment  becoming  due from the
        Warrantors,  or at some subsequent date becomes  entitled to make such a
        recovery,  then the  Purchaser  shall procure that the Company shall (in
        either  of  those  cases)  but  without  prejudice  to  the  Warrantors'
        obligations  to make payment  under part 2 or for breach of any Taxation
        Warranties  on the due  date,  promptly  notify  the  Warrantors  of its
        entitlement  and the  Purchaser  shall  procure,  if so  required by the
        Warrantors,  (provided the Warrantors  shall first indemnify the Company
        to the Purchaser's reasonable  satisfaction against all losses, damages,
        reasonable costs and expenses which may be incurred by the Company) that
        the Company takes such

                                       41



        reasonable steps as the Warrantors  shall reasonably  request to enforce
        that recovery  (keeping the  Warrantors  informed of the progress of any
        action taken) and shall account to the Warrantors for so much of any sum
        so recovered (less (a) any Tax payable by the Company  thereon,  and (b)
        all reasonable  charges,  costs and expenses  incurred by the Company in
        recovering  such sum) as does not exceed the amount which the Warrantors
        have paid or that is due to be paid by the Warrantors under this Deed).

6       APPEALS AND CONDUCT OF CLAIMS

6.1     If the  Purchaser or the Company (or any of their  officers,  employees,
        servants or agents)  becomes aware of a Claim,  the  Purchaser  shall or
        shall procure that the Company  shall as soon as reasonably  practicable
        give written  notice of the Claim to the  Warrantors  and, in any event,
        where a statutory or other time limit is applicable for responding to or
        appealing  against  the Claim or to any  assessment,  notice,  demand or
        other  document  issued (or deemed to be issued) or action  taken  which
        constitutes  the Claim,  the Purchaser  shall give written notice of the
        Claim to the  Warrantors  at least 14 days  prior to the  expiry of such
        time limit.  To the extent  reasonably  possible,  having  regard to the
        information  and time  available,  such written  notice shall include an
        estimate of the Warrantors'  liability under this schedule in respect of
        such Claim,  the basis of  calculation of that estimate and such details
        of the Claim as are then available to the Purchaser or the Company.

6.2     The Purchaser shall, and shall procure that the Company shall, take such
        action to appeal,  protest against,  mitigate,  reduce,  avoid, dispute,
        resist  or  compromise  the  Claim and make  available  such  documents,
        information   and  assistance  in  connection  with  the  Claim  as  the
        Warrantors (or the Vendors' Representatives on behalf of the Warrantors)
        may by written notice request  provided the Warrantors  shall  indemnify
        the Purchaser and the Company to their reasonable  satisfaction  against
        reasonable  costs and  expenses  and any fines,  penalties,  surcharges,
        interest  or  additional  Taxation  which the  Purchaser  or the Company
        incurs as a result of taking such action or providing  such  information
        and assistance.

6.3     The  Warrantors  (or  the  Vendors'  Representatives  on  behalf  of the
        Warrantors) may, if the Warrantors (or the Vendors'  Representatives  on
        behalf of  Warrantors)  request in writing  and the  Purchaser  consents
        (such  consent  not to be  unreasonably  withheld  or  delayed)  to such
        request, elect to have any action referred to in paragraph 6.2 conducted
        by professional advisers acting in the name of the Company but reporting
        to,  and taking  instructions  from,  the  Warrantors  (or the  Vendors'
        Representatives  on  behalf  of  the  Warrantors)  in  which  event  the
        provisions of paragraph 6.4 shall apply.

6.4     The Warrantors hereby undertake to the Purchaser to:

        6.4.1   keep the  Purchaser  informed  of all  matters  relating  to the
                action  and  deliver  to the  Purchaser  copies of all  material
                correspondence relating to the action;

        6.4.2   obtain the prior written  approval of the  Purchaser  (not to be
                unreasonably  withheld or delayed) to the content and sending of
                written  communications  relating  to the  action to a  Taxation
                Authority; and

                                       42



        6.4.3   obtain the prior written  approval of the  Purchaser  (not to be
                unreasonably withheld or delayed) to:

                (a)     the  settlement  or compromise of the Claim which is the
                        subject of the action; and

                (b)     the agreement of any matter in the conduct of the action
                        which is likely to affect the amount of the Claim.

6.5     The Purchaser  shall not be obliged to procure that the Company take any
        action  under this clause which  involves  contesting a Claim before any
        appellate  tribunal or court unless the Warrantors furnish the Purchaser
        with the written  opinion of Counsel of at least ten years call approved
        by the  Purchaser  (such  approval  not to be  unreasonably  withheld or
        delayed) who is  experienced  in the subject  matter of the Claim to the
        effect  that an appeal  in  respect  of the  matter  in  question  has a
        reasonable prospect of being won.

6.6     If at any time  the  Warrantors  request  that the  Purchaser  take,  or
        procure that the Company take, any action  referred to in paragraph 6.2,
        but do not  make  any  request  referred  to in  paragraph  6.3  (or the
        Purchaser  does not  consent to any such  request),  the  provisions  of
        paragraph  6.4 shall  apply as if  references  to "the  Warrantors"  are
        references  to "the  Purchaser"  and  reference to "the  Purchaser"  are
        references to "the Warrantors".

7       DISPUTES

7.1     In the  event of any  dispute  under  paragraph  3, 4, 5, 6 or 8 of this
        schedule,  such dispute  shall if the Parties so agree be  determined by
        the  Independent  Expert (acting as expert and not as arbitrator) and in
        the absence of manifest error his determination  shall be conclusive and
        binding on the  Parties.  The proper  charges and  disbursements  of the
        Independent  Expert  shall be paid and  borne  on each  occasion  by the
        Parties  concerned in such proportions as the Independent  Expert may in
        his absolute discretion consider fair and reasonable.

7.2     If the Vendors'  Representative  (as agent of the Warrantors) on the one
        hand  or  the   Purchaser  on  the  other  is   dissatisfied   with  any
        determination  of the  Auditors,  the matter  shall be  referred  to the
        Independent  Expert for  determination in accordance with the provisions
        of paragraph 7.

8       CONDUCT OF PRE-COMPLETION TAXATION AFFAIRS

8.1     Subject to complying  with the  provisions of paragraph  8.2 below,  the
        Warrantors  or  their  duly  authorised  agents  shall,  at the cost and
        expense of the Company (save where in accordance with good practice or a
        legal   requirement  such  returns  should  have  been  prepared  before
        Completion  in which  case the  cost  and  expense  shall be that of the
        Warrantors)  prepare the  corporation tax returns of the Company for all
        accounting periods ending on or prior to the Latest Accounts Date to the
        extent that the same shall not have been prepared before

                                       43



        Completion. The Warrantors or their duly authorised agents shall, at the
        cost and expense of the  Company  (save  where in  accordance  with good
        practice or a legal  requirement  such returns should have been prepared
        before  Completion  in which case the cost and expense  shall be that of
        the  Warrantors)  prepare  all  documentation  and deal with all matters
        (including  correspondence)  relating to the  corporation tax returns of
        the Company for all accounting  periods ending on or prior to the Latest
        Accounts.

8.2     The Warrantors covenant with the Purchaser:

        8.2.1   to keep the  Purchaser  and its duly  authorised  agents and the
                Company  informed  of  all  material  matters  relating  to  the
                submission,  negotiation  and agreement of such  corporation tax
                returns and computations;

        8.2.2   that  no  such   computations   or  returns  nor  any   material
                correspondence  pertaining to the  negotiations  or agreement of
                such  computations  or  returns  shall  be  transmitted  to  any
                Taxation   Authority   without  first  being  submitted  to  the
                Purchaser  and the Company or their duly  authorised  agents for
                their comments and for the  Purchaser's  approval and shall only
                finally  be  submitted  or  transmitted  on the  receipt  of the
                written approval of the Purchaser or its duly authorised  agent,
                such approval not to be unreasonably withheld or delayed.

8.3     In the event that the  provisions  of paragraph  8.2 have been  complied
        with by the  Warrantors  the  Purchaser  shall  procure that the Company
        shall  cause the returns  mentioned  in  paragraph  8.2 (and all claims,
        elections,  disclaimers,  surrenders and consents  assumed to be made or
        given therein) to be authorised, signed and submitted to the appropriate
        Taxation  Authority and generally do all such things as may be necessary
        to  give  effect  to  such  returns,  claims,  elections,   disclaimers,
        surrenders or consents provided that the Purchaser shall not be required
        to procure any such action where in the Purchaser's  reasonable opinion,
        it considers the relevant  returns,  documents or  correspondence do not
        make proper  disclosure of any relevant matters or are legally deficient
        in any other regard.

8.4     The Purchaser  shall (if  requested in writing by the  Warrantors or the
        Vendors'  Representative  on their  behalf)  procure  that  the  Company
        promptly makes or gives such returns,  claims,  elections,  disclaimers,
        surrenders  and  consents in  relation to Taxation  which it was assumed
        would be made or given in computing any  provision  which appears in the
        Completion Accounts (or in eliminating any provision which would have so
        appeared) or which relate to any Vendors Relief,  and generally does all
        such things as may be necessary to give effect to such returns,  claims,
        elections, surrenders or consents.

8.5     The Purchaser shall procure that the Company keeps the Warrantors  fully
        informed of its Taxation affairs in respect of the accounting  period of
        the  Company  current  at  Completion  and shall  promptly  provide  the
        Warrantors  with  copies of all  relevant  documents  and not submit any
        correspondence  or submit or agree any  return or  computation  for such
        period  to any  Taxation  Authority  without  giving  the  Warrantors  a
        reasonable  opportunity to make representations  thereon and without the
        written  consent of the Warrantors  (such consent not to be unreasonably
        withheld or delayed).

8.6     The  Purchaser  shall  provide,  and  shall  procure  that  the  Company
        provides, the Warrantors with access to such documents,  information and
        assistance (including without limitation,  access to, and to take copies
        of, books, accounts

                                       44



        and records) as the Warrantors may reasonably require in connection with
        its conduct of the Company's Taxation affairs pursuant to this paragraph
        8.

9       PURCHASER'S COVENANT

9.1     The Purchaser  covenants with each Warrantor to pay to that Warrantor an
        amount equal to any Actual  Taxation  Liability of that  Warrantor or of
        any  company  which is under the control of that  Warrantor  (or of that
        Warrantor  and/or  any other  Warrantor  or  Vendor)  at any time  after
        Completion  (and any costs and  expenses  incurred by that  Warrantor or
        that company in relation to such Actual Taxation  Liability or in making
        any  claim  under  this  paragraph  9.1),  where  such  Actual  Taxation
        Liability:

        9.1.1   arises as a result of the  failure by the  Company to  discharge
                after  Completion  an Actual  Taxation  Liability  for which the
                Company is primarily  liable and which is not within paragraph 1
                of part 2; or

        9.1.2   arises as a result of the Company  paying  after  Completion  an
                abnormal  amount  by way of  dividend  (within  the  meaning  of
                section 709(4) ICTA) in the  circumstances  specified in section
                704C ICTA.

9.2     If the Purchaser  becomes liable to make a payment under  paragraph 9.1,
        the  Purchaser  shall pay such amount in cleared  immediately  available
        funds on or before the later of the date 2  business  days  before  that
        Actual  Taxation  Liability  is finally  due and  payable and the date 2
        business  days after the date of written  demand on the Purchaser by the
        relevant Warrantor.

9.3     The provisions of paragraph 6 of this part shall apply mutatis  mutandis
        to this  paragraph  9, and for these  purposes  any  reference  in those
        paragraphs  to the  Warrantors  shall  be  read  as a  reference  to the
        Purchaser and vice versa (as appropriate).

                                       45



                           Part 2 - Taxation Covenant
                           --------------------------

1       COVENANT BY THE WARRANTORS

1.1     Subject to the  provisions  of part 1 and of schedule 8, the  Warrantors
        hereby  covenant  with the  Purchaser to pay to the  Purchaser an amount
        equal to:

        1.1.1   any Actual Taxation Liability of the Company arising as a result
                of:

                (a)     an Event  occurring  or  deemed to have  occurred  on or
                        before Completion; or

                (b)     any income, profits or gains earned, accrued or received
                        on or before or in  respect  of any  period  ended on or
                        before the date of Completion and for these purposes the
                        period  from  the date of the  last  statutory  accounts
                        until  the  date of the  Completion  Accounts  shall  be
                        treated as a period for Taxation purposes;

        1.1.2   any Actual Taxation Liability of the Company arising pursuant to
                section  179 TCGA as a result of (a) a  disposal  of the  Shares
                before  Completion;  or (b) the sale and  purchase of the Shares
                pursuant to this Agreement;

        1.1.3   any Deemed Taxation Liability;

        1.1.4   any Actual  Taxation  Liability  in respect of  inheritance  tax
                which:

                (a)     is at  Completion  a charge on, or gives rise to a power
                        to sell, mortgage or charge, any of the shares or assets
                        of the Company; or

                (b)     after Completion becomes a charge on, or gives rise to a
                        power to sell,  mortgage or charge, any of the shares or
                        assets of the Company being an Actual Taxation Liability
                        arising  as a result of the death of any  person  within
                        seven  years  after a  transfer  of  value  (or a deemed
                        transfer  of  value)  if a  charge  on or power to sell,
                        mortgage or charge any such shares or assets  could,  if
                        the death had occurred immediately before Completion and
                        the  inheritance tax payable as a result thereof had not
                        been paid, have existed at Completion; or

                (c)     arises as a result of a transfer of value  occurring  or
                        being deemed to occur on or before  Completion  (whether
                        or not in  conjunction  with  the  death  of any  person
                        whenever  occurring)  which  increased or decreased  the
                        value of the estate of the Company;

                In determining the amount of any such Actual Taxation  Liability
                in respect of  inheritance  tax and whether a charge on or power
                to sell,  mortgage  or charge any of the shares or assets of the
                Company exists at any time the fact that any Taxation is not yet
                payable or may be paid by instalments  shall be disregarded  and
                such  Taxation  shall be treated as becoming due and a charge or
                power to sell,  mortgage or charge as arising on the date of the
                transfer  of value or other  date or event on or in  respect  of
                which it becomes payable or arises and the provisions of section
                213 Inheritance Tax Act 1984 shall not apply thereto;

        1.1.5   any reasonable third party costs,  fees and expenses  reasonably
                incurred  by the  Purchaser  or the  Company  as a result of any
                Actual Taxation Liability within

                                       46



                paragraph  1.1.1,  1.1.2,  1.1.4 or 1.1.6  any  Deemed  Taxation
                Liability  within  paragraph 1.1.3 or in successfully  taking or
                defending any action under this part 2.

        1.1.6   any Actual  Taxation  Liability  of the Company  which arises in
                respect  of the  exercise  after  Completion  of any  options to
                acquire  shares in the  Company  or any  member of the  Vendor's
                Group  which were  granted  by the  Company or any member of the
                Vendor's  Group to any person in respect of their  position as a
                director or employee before Completion;

        1.1.7   any Taxation  Liability  of the Company  which arose as a result
                of:

                (a)     the liquidation of Inhoco 2387 Limited; or

                (b)     the  acquisition  of  the  Thalidomide  business  by the
                        Company  from  Inhoco  2387   Limited   pursuant  to  an
                        agreement dated 16 November 2001.

2       PAYMENT

2.1     If the Warrantors are or become liable to make a payment under this part
        2 in respect of:

        2.1.1   an Actual  Taxation  Liability,  the  Warrantors  shall pay such
                amount on or before the date 5  business  days after the date of
                written  notice  from the  Purchaser  to the  Warrantors  of the
                amount which the  Warrantors  are required to pay and requesting
                payment or, if later,  the date 2 business  days before the date
                on which the Actual  Taxation  Liability  in question is due for
                payment;

        2.1.2   a Deemed  Taxation  Liability,  the  Warrantors  shall  pay such
                amount by the later of 5 business days after the date of written
                notice from the Purchaser to the  Warrantors of the amount which
                the Warrantors are required to pay and requesting payment, and:

                (a)     in the case of a Set Off Liability,  the date 2 business
                        days  before  the  date on  which  the  Actual  Taxation
                        Liability  referred  to in the  definition  of that term
                        would otherwise have become due for payment;

                (b)     in  the  case  of an  Unavailable  Relief  Liability,  2
                        business  days  before  the  date on  which  the  Actual
                        Taxation Liability referred to in the definition of that
                        term is actually due for payment; or

                (c)     in the case of an Unavailable  Repayment Liability,  the
                        date on which the repayment of Taxation  would have been
                        made but for that unavailability; or

        2.1.3   any amount within  paragraph 1.1.4 the Purchaser will notify the
                Warrantors in writing of such amount  specifying  details of the
                services for which those costs,  fees and expenses were incurred
                and the  circumstances  in  which  they  were  obtained  and the
                Warrantors  shall  pay  such  amount  on or  before  the  date 5
                business days after the date of such notice.

2.2     Sums not paid by the  Warrantors  on the dates  specified in  paragraphs
        2.1.1 and 2.1.2 shall bear interest  (which shall accrue from day to day
        after, as well as

                                       47



        before,  judgment)  at the base rate from time to time of  Barclays  plc
        from the date  following the specified  date up to and including the day
        of actual payment of such sums.

3       TAX ON PAYMENTS BY THE WARRANTORS

3.1     The Warrantors  shall be entitled to deduct or withhold from any payment
        made under this part 2 or for breach of any  Warranty,  any deduction or
        withholding  (whether in respect of Taxation or  otherwise)  required by
        law.

3.2     If any  amount  paid to the  Purchaser  under  this part 2 is subject to
        Taxation (other than any amount paid under  paragraph  2.2),  whether by
        way of deduction or  withholding  from the payment paid to the Purchaser
        or by way of  Taxation  on the amount  received  by the  Purchaser,  the
        Warrantors  covenant to pay to the  Purchaser  such  further sum as will
        ensure  that the  Purchaser  receives  and  retains a net amount  (after
        taking into  account  such  Taxation)  equal to the full amount which it
        would have  received  and  retained had the payment in question not been
        subject to Taxation.  In the event that the Company  receives any credit
        or benefit in respect of any such Taxation  deduction or  withholding it
        shall  forthwith  pay an amount  equal to such  credit or benefit to the
        Warrantors.

3.3     If the benefit of this  schedule  is assigned  (in whole or in part) the
        Warrantors  shall have no greater  liability  under this schedule to any
        person to whom the benefit has been assigned than they would have had to
        the Purchaser in the absence of such assignment.

                                       48



                          Part 3 - Taxation Warranties
                          ----------------------------

1       POST LATEST ACCOUNTS DATE

1.1     Since the Latest Accounts Date:

        1.1.1   no  accounting  period  (as  defined  in section 12 ICTA) of the
                Company has ended as referred to in section 12(3) ICTA;

        1.1.2   the  Company  has not paid any  Taxation  after its due date for
                payment;

        1.1.3   the  Company has not  declared or paid any  dividend or made any
                other distribution for the purposes of any Taxation.

1.2     The Latest  Accounts  make  proper  provision  or reserve  for  Taxation
        (including  deferred  taxation)  for which the  Company was liable or in
        respect  of the  accounting  period of the  Company  ended on the Latest
        Accounts Date.

2       COMPLIANCE

2.1     There is no dispute between the Company and any Taxation Authority,  the
        Company  is not and has not at any  time in the  last 3 years  been  the
        subject of an investigation, audit or non-routine visit, by any Taxation
        Authority and as far as the Warrantors are aware (having made reasonable
        enquiries of persons  other than any Tax  Authority)  there are no facts
        which are likely to give rise to any such dispute or investigation.

2.2     The  Company is not and has not at any time  within the 3 years prior to
        the  date  hereof  been  liable  to pay any  penalty,  fine,  surcharge,
        interest or similar  amount in relation  to  Taxation  and its  Taxation
        reporting  obligations  and as far as the  Warrantors  are aware (having
        made reasonable enquiries of persons other than any Tax Authority) there
        are no facts  which are  likely to cause it to become  liable to pay any
        such penalty, fine, surcharge, interest or similar amount.

2.3     Within the last 3 years,  the Company has duly and  punctually  complied
        with all its obligations to deduct Taxation from payments made by it and
        to account for such Taxation to any Taxation Authority and in particular
        has  properly  operated  the  PAYE  system,  by duly  deducting  tax and
        national  insurance  contributions  (as  appropriate)  from all payments
        made, or treated as made, to its  employees  and former  employees,  and
        accounting  to the  Taxation  Authorities  for all  amounts so  deducted
        insofar as the time for so accounting  has fallen due and has maintained
        proper  records of these  payments and  deductions and has complied with
        all its reporting  obligations in connection with the benefits  provided
        for its employees and directors.

2.4     All    payments,    returns,    self-assessments,     self-certificates,
        notifications, computations and payments, accounts, notices, statements,
        reports  and  registrations  which have been or should have been made or
        filed by or in respect of the Company for any Taxation  purpose (i) have
        been made or filed  within the  requisite  periods and on a proper basis
        and are complete,  up-to-date  and are true and accurate in all material
        respects.

                                       49



2.5     All  Taxation  for which  the  Company  is liable  (and the due date for
        payment of which has fallen  due) has been duly paid and the Company has
        not  incurred  any  liabilities  to interest or penalties in relation to
        Taxation.

2.6     The  disclosure  letter  contains  details of any written  dispensation,
        concession or special arrangements  affecting the Company requested from
        or agreed by any Taxation Authority.

3       CLOSE COMPANIES

3.1     The Company is not and has never been a close investment-holding company
        within the meaning of section 13A ICTA.

3.2     The Company has not at any time:

        3.2.1   made or agreed to make any loan or advance which loan or advance
                remains   outstanding  or  effected  or  agreed  to  effect  any
                transaction  within  section  419,  421 or 422 ICTA or since the
                Latest  Accounts  Date  released  or  written  off or  agreed to
                release  or write  off the whole or any part of any such loan or
                advance; or

        3.2.2   made a transfer  of value  within the  provisions  of section 94
                IHTA; or

        3.2.3   made or agreed to make any distribution within section 418 ICTA.

4       DISTRIBUTIONS AND PAYMENTS

4.1     No  distribution  (within the meaning of sections  209 and 210 ICTA) has
        been made by the Company during the 6 years ended on the Latest Accounts
        Date (except as provided in the Accounts).

4.2     The Company has not made or received any exempt  distribution within the
        meaning of section 213 ICTA, and has at no time been a relevant  company
        in relation to an exempt  distribution  for the purposes of that section
        or concerned in an exempt  distribution  for the purposes of section 214
        ICTA.

4.3     The Company has not at any time received a capital distribution to which
        section 189 TCGA could apply.

4.4     The Company has not paid,  and has not elected  that any dividend it has
        paid or declared be treated as, a foreign income divided as described in
        Chapter VA Part VI ICTA.

4.5     The Company has not on or after 6th April 1965:

        4.5.1   repaid,  redeemed  or  purchased  or agreed to repay,  redeem or
                purchase any of its share capital; or

        4.5.2   capitalised  or  agreed to  capitalise  in the form of shares or
                debentures, any profits or reserves of any class or description,
                or otherwise  issued or agreed to issue share capital  otherwise
                than for new consideration (as defined in section 254 ICTA).

                                       50



5       EMPLOYEE BENEFITS

5.1     The Completion  Disclosure  Letter contains full details of all the long
        term  incentive  plans,  share option  schemes and profit share  schemes
        established by the Company whether or not approved by the Company.

5.2     The Disclosure  Letter sets out details of all interests in or rights to
        acquire shares in the Company to which  directors are or may be entitled
        in respect of which:

        5.2.1   the  Company  is or may be  required  to  notify  to the  Inland
                Revenue under relevant provisions of ITEPA; or

        5.2.2   the  Company  may have  liabilities  to  account  for income tax
                and/or national insurance contributions.

5.3     The Company has not  established a qualifying  employee share  ownership
        trust within the meaning of section 74 and schedule 5 FA 1989.

6        GROUP TRANSACTIONS

6.1     The Company is not/has not been a member of a group.

6.2     No asset of the Company shall be deemed disposed of and reacquired under
        s179  TCGA by  virtue  of or in  consequence  of the sale of the  Shares
        pursuant to this  Agreement  or any other event  occurring  on or before
        Completion.

6.3     The  Company  is not  liable  to pay any  amount  of  Taxation  which is
        primarily  a liability  of any other  person and in respect of which the
        Company is so liable as a result of the failure of that other  person to
        discharge such Taxation within a specified period.

7        RESIDENCE AND OFFSHORE INTERESTS

7.1     The  Company  is and has at all times been  resident  only in the United
        Kingdom for Tax purposes and is not and has not been treated as resident
        or  as  having  a  branch,   agency,  place  of  business  or  permanent
        establishment  in  any  other  jurisdiction  for  any  Taxation  purpose
        (including  under any double  taxation  treaty or agreement)  and is not
        liable to Tax (other than any tax withheld or deducted at source) in any
        other jurisdiction.

7.2     The  Company  is  not  liable  for  any  Taxation  as the  agent  or tax
        representative of any other person or business and does not constitute a
        permanent  establishment of any other person, business or enterprise for
        any Taxation purposes.

7.3     The Company does not and has at no time owned a  beneficial  interest in
        the capital of a company  which is resident  outside the United  Kingdom
        and which  would be a close  company if it were  resident  in the United
        Kingdom,  in circumstances  such that a chargeable gain accruing to that
        other company could be appointed to the Company under section 13 TCGA.

                                       51



8       NON-ARM'S LENGTH TRANSACTIONS

8.1     There is no outstanding Inland Revenue charge (as defined in section 237
        IHTA) over any asset of the  Company or over any of the Shares and there
        are no circumstances in which such a charge could arise.

8.2     There  are in  existence  no  circumstances  by virtue of which any such
        power as is mentioned in section 212 IHTA could be exercised in relation
        to any asset of the Company or to any of the Sale Shares or by virtue of
        which  any such  power  could be  exercised  but for the  provisions  of
        section 204(6) IHTA.

8.3     The Company has not been a party to associated operations in relation to
        a transfer of value within the meaning of section 268 IHTA.

8.4     The Company has not  received  any asset by way of gift as  mentioned in
        section 282 TCGA.

8.5     No expenditure  incurred by the Company on the acquisition of any shares
        is liable to be reduced under the provisions of section 125 TCGA.

9       VAT

9.1     The  Company  is  duly   registered  for  the  purposes  of  VATA.  Such
        registration is not subject to any conditions  imposed by or agreed with
        the  Commissioners  of Customs and Excise.  Within the last 3 years, the
        Company has complied in all material  respects with VATA and all orders,
        provisions,  directions or other  conditions made or imposed  thereunder
        (including  for the  avoidance  of doubt any  regulations)  or under any
        other law  relating to VATA and the Company has at all times  punctually
        paid and made all payments and returns required under the legislation.

9.2     The  Company  is not and has  never  been a  member  of a group  for the
        purpose of section 43 VATA.

9.3     No direction has been issued to the Company  under  schedule 9A VATA and
        there are no circumstances in which such a direction could be issued.

9.4     The  Company  has not  within  the two years  ending on the date of this
        Agreement been served with any penalty liability notice under section 64
        VATA or any  surcharge  liability  notice under  section 59 VATA or been
        issued with any written warning under section 76(2) VATA.

9.5     Details of all elections made by the Company or a relevant  associate of
        it (within the meaning of  paragraph  3,  schedule 10 VATA)  pursuant to
        paragraph 2, schedule 10 VATA are set out in the  Completion  Disclosure
        Letter and there are no  circumstances in which a supply relating to the
        grant of an  interest  in right  over a licence  to  occupy  any land or
        building  or any part of any land or building  comprised  within such an
        election  could be other  than a taxable  supply by virtue of  paragraph
        2(3AA), schedule 10 VATA or otherwise.

                                       52



9.6     The Company has not registered, and is not required to register, for VAT
        purposes  (or for the  purposes  of any  similar  tax on added  value or
        turnover) in any country other than the United Kingdom.

9.7     Any transfer of assets made to the Company since its incorporation  have
        qualified  as a transfer of a going  concern for the purposes of section
        49 VATA.

9.8     The Company  does not own any assets to which Part XV of the Value Added
        Tax Regulations 1995 applies.

9.9     The  Company  is, and has in respect  of all its  prescribed  accounting
        records ending after the Accounts  Date,  been able to obtain credit for
        all input tax (as defined in section 24 VATA) which it has  incurred and
        has not carried out any  transaction  which might  result in it becoming
        exempt or partially exempt for VAT purposes.

9.10    The  Company  has not  received  a notice or is not  otherwise  aware of
        anything which indicates that the grant to the Company of an interest in
        or right over land or of a licence to occupy  land will not be an exempt
        supply because of an election under Schedule 10 VATA.

10      INSURANCE PREMIUM TAX

10.1    The  Company is not nor has ever been an insurer  (as defined by section
        73 FA 1994) or a taxable  intermediary  (as  defined by  section  52A FA
        1994) for the purposes of insurance premium tax.

10.2    The  Company is not liable for nor to account  for any amount in respect
        of insurance premium tax.

11      STAMP DUTY AND STAMP DUTY RESERVE TAX AND STAMP DUTY LAND TAX

11.1    All documents  which confer any right or title upon the Company to which
        the Company  was a party as a  purchaser,  lessee or assignee  and which
        attract  stamp or  transfer  duty in the United  Kingdom  have been duly
        stamped.

11.2    The Company has not been party to any transaction whereby the Company is
        or could become liable to or to account for stamp duty reserve tax.

11.3    The Company  does not have any  undischarged  liability to pay any stamp
        duty land tax ("SDLT").

12      AIR PASSENGER DUTY

12.1    The Company does not own and has never owned a  chargeable  aircraft (as
        defined by section 28 FA 1994) for the purposes of air passenger duty.

12.2    The  Company is not liable for nor to account  for any amount in respect
        of air passenger duty.

                                       53



13      LANDFILL TAX

13.1    The Company is not and has never been a landfill  site  operator  within
        the meaning of section 41 FA 1996.

13.2    The  Company is not liable for nor to account for any amount of landfill
        tax.

13.3    The Company is not a party to any  contract to which the  provisions  of
        any of  paragraphs 45 to 47  (inclusive)  of schedule 5 FA 1996 apply or
        could apply.

14      CAPITAL ALLOWANCES

14.1    The Company has not  incurred  any  expenditure  on plant and  machinery
        (including fixtures) within Part 2 CAA.

14.2    The Company does not own any assets which  qualify or have  qualified as
        industrial buildings for the purposes of CAA.

15      CAPITAL GAINS

15.1    The Company has  sufficient  records to enable it to determine  the base
        cost of any capital asset held as at Completion.

16      LOAN RELATIONSHIPS, ETC

16.1    The Company is not  indebted in  circumstances  in which any interest or
        other return on indebtedness will or may be treated as a distribution or
        disallowed  as  a  deduction  under  section  209  ICTA  (definition  of
        distribution),  or  paragraph  13  Schedule  9  Finance  Act 1996  (loan
        relationships for unallowable purposes).

16.2    The Company is not a party to any loan  relationship  to which paragraph
        11 Schedule 9 Finance Act 1996 applies or may apply (transactions not at
        arm's length) or to which sections 92 (convertible  securities  etc), 93
        (relationships  linked to the value of chargeable assets) or Schedule 13
        (relevant discounted securities) Finance Act 1996 apply.

16.3    The Company does not have in issue or own any deep discount  securities,
        deep gain  securities  or  convertible  securities  which were issued or
        acquired prior to 1 April 1996.

                                       54



                                   SCHEDULE 4

                             Part 1 - The Warranties
                             -----------------------



1       FACTUAL STATEMENTS AND INFORMATION

1.1     To the best of the Warrantors'  knowledge,  information and belief,  the
        information  contained in the documents  listed in Schedule 11 is in all
        material  respects true and accurate and not  misleading in any material
        respect.

1.2     The  information  contained in Schedules 1 and 5 to this Agreement is in
        all  material  respects  true and  complete  and not  misleading  in any
        material respects.

2       CONSTITUTION AND STRUCTURE OF THE COMPANY

2.1     The Company has no subsidiaries.

2.2     The Company has no:

        2.2.1   interest in the share  capital of, or other  investment  in, any
                body corporate;

        2.2.2   interest in any partnership,  joint venture, consortium or other
                unincorporated association or arrangement for sharing profit; or

        2.2.3   branch,  agency,  place of business or  permanent  establishment
                outside the United  Kingdom  ("OVERSEAS  BRANCH") or substantial
                assets outside the United Kingdom,

        and has no  outstanding  obligation  to  acquire  any such  interest  or
        overseas  branch or in respect of any such  interest or overseas  branch
        formerly owned by it or agreed to be acquired by it.

2.3     There is no shadow director of the Company.

3       COMPLIANCE WITH LEGAL REQUIREMENTS

3.1     Compliance  has been made in all respects with all legal and  procedural
        requirements   and  other   formalities   in  relation  to  the  Company
        concerning:

        3.1.1   the  memorandum  and  articles  of  association  (including  all
                resolutions passed or purported to have been passed); and

        3.1.2   issues of shares, debentures or other securities.

3.2     The Company has obtained all licences,  permissions,  consents,  permits
        and other  approvals  which are  necessary  to be obtained by it for the
        carrying on of the Company's business in the places and in the manner in
        which such  business  is now  carried on and the lack of which  would be
        likely  to have a  material  adverse  effect  upon such  business  or to
        require a material alteration in the manner in

                                       55



        which such business is carried on; such licences, permissions, consents,
        permits and approvals,  so far as the Warrantors are aware,  are in full
        force and effect,  are  unconditional or subject only to conditions that
        have been satisfied and have been complied with in all material respects
        and there  are no  circumstances  (including,  without  limitation,  the
        execution  or  performance  of  this  Agreement  or any  document  to be
        executed  pursuant to it) known to the Warrantors which indicate that it
        is likely that any of such licences,  permissions,  consents, permits or
        approvals  might be suspended,  cancelled or revoked prior to its stated
        expiry date or not renewed.

3.3     All statutory  registers  required by law to be kept by the Company have
        been  properly   written  up  and  the  Company  has  not  received  any
        application or request for  rectification of its statutory  registers or
        any notice or allegation that any of them is incorrect.

4       SHARE CAPITAL

4.1     There is no option,  right to acquire or Security  Interest  on, over or
        affecting  any  shares  in the  capital  of  the  Company,  there  is no
        agreement,  arrangement,  obligation or commitment to give or create any
        of the foregoing and so far as the Warrantors  are aware,  no person has
        made any claim to be entitled to any of the foregoing.

4.2     No part of the unissued  share capital of the Company is under option or
        is agreed or resolved  conditionally or  unconditionally to be issued or
        put under option.

4.3     The numbers of the Shares set  opposite the names of each of the Vendors
        in part 1 of schedule 6 are legally and beneficially owned by them.

4.4     The Shares set opposite the names of the Vendors in part 1 of Schedule 5
        constitute the entire  allotted and issued share capital of the Company,
        have been properly allotted and issued and are fully paid or credited as
        fully paid.

4.5     No person has the right  (whether  exercisable  now or in the future and
        whether  contingent  or not) to call  for  and  there  is no  agreement,
        arrangement or obligation relating to, the allotment,  issue,  transfer,
        redemption  or  repayment  of any share or loan  capital of the  Company
        whether  under  any  option,  right  of  pre-emption  or  conversion  or
        otherwise.

4.6     So far as the  Warrantors are aware none of the Shares was or represents
        assets which were,  the subject of a transfer at an  undervalue  (within
        the  meaning of  sections  238 or 339  Insolvency  Act 1986)  within the
        previous five years.

5       CONSTITUTIONAL MATTERS

5.1     The copy of the  memorandum  and articles of  association of the Company
        annexed to the  Disclosure  Letter is true and complete and has embodied
        in it or annexed to it copies of all  resolutions  and agreements as are
        referred to in section 380(2) of the CA 1985.

                                       56



5.2     The  statutory  books,  minute  books and other  books which the CA 1985
        requires the Company to keep (other than accounting records),  are up to
        date, in its possession  and comprise a complete and accurate  record of
        the matters  which the Company is required by the Act to record.  To the
        Warrantors'  knowledge,  no  notice  or  allegation  that any of them is
        incorrect or should be rectified has been received by the Company.

5.3     The Company has properly  prepared  and filed all returns,  resolutions,
        particulars  and other  documents  which it is required to file with the
        Registrar of Companies or any other  governmental  or regulatory body or
        agency.

5.4     Due  compliance  has been made with all the provisions of the CA 1985 in
        connection  with the  formation of the Company,  the  allotment,  issue,
        purchase, redemption,  repayment or conversion of shares, debentures and
        other  securities  in  the  Company  or  the  grant  of  options  in any
        securities in the Company,  the reduction of the  authorised  and issued
        share  capital of the Company (if any) and the payment of  dividends  by
        the Company.

5.5     The information  contained in schedule 1 is complete and accurate in all
        respects and not misleading in any respect.

5.6     Copies of the  constitutional  documents of the Company  attached to the
        Disclosure  Letter are  complete  and  accurate  copies of the  relevant
        original documents.

6       LATEST ACCOUNTS

6.1     The  Latest  Accounts  (a copy of which  is  annexed  to the  Disclosure
        Letter) show a true and fair view of the state of affairs and the assets
        and liabilities of the Company as at the Latest Accounts Date and of the
        profits and losses of the Company  for the  financial  year ended on the
        Latest Accounts Date.

6.2     The Latest  Accounts have been prepared and audited on a recognised  and
        consistent  basis in accordance  with the law and applicable  standards,
        principles  and  practices  generally  accepted  in the  United  Kingdom
        ("Accounting   Practice")   and  make  all  required   and   appropriate
        disclosures.

6.3     In the Latest Accounts:

        6.3.1   and  in  the  audited  accounts  for  the  preceding  accounting
                periods,   the  rates  of  depreciation  and  amortisation  were
                sufficient  to write  down the value of the fixed  assets of the
                Company  to nil not later than the end of their  useful  working
                lives. The bases and rates of depreciation and amortisation used
                in the  Latest  Accounts  were  the  same as  those  used in the
                audited  accounts of the Company  for the  preceding  accounting
                periods;

        6.3.2   stock and work in progress (except long-term  contract balances)
                were  valued in the same way as in the  audited  accounts of the
                Company for the three  preceding  accounting  periods and on the
                basis of the lower of cost or net realisable value at the Latest
                Accounts Date. The long-term

                                       57



                contract  balances were valued in the same way as in the audited
                accounts of the Company for the preceding accounting periods and
                on the basis of net cost less foreseeable losses and payments on
                account at the Latest  Accounts Date. All redundant and obsolete
                stock was written off and all  slow-moving and damaged stock was
                written down appropriately;

        6.3.3   provision  or reserve (as  appropriate)  in  accordance  with UK
                generally accepted  accounting  principles has been made for all
                bad and doubtful debts, all liabilities and obligations (actual,
                contingent or disputed) and all financial  commitments  existing
                at the Latest Accounts Date; and

        6.3.4   provision  or reserve (as  appropriate)  in  accordance  with UK
                generally accepted  accounting  principles has been made for all
                Tax  liable  to be  assessed  on the  Company  or for  which the
                Company  is or may  become  accountable  (whether  primarily  or
                otherwise).

6.4     The accounting  policies adopted for the purpose of preparing the Latest
        Accounts are the same as those  adopted for the purpose of preparing the
        audited  accounts of the Company for the  preceding  accounting  periods
        (except as stated in the  Accounts or any of those  preceding  accounts)
        and none of those preceding accounts were qualified by the auditors.

6.5     The profits and losses of the Company  shown by the Latest  Accounts and
        by the audited  accounts of the  Company  for the  preceding  accounting
        periods  and the trend of  profits  and  losses  thereby  shown have not
        (except  as  disclosed   in  such   accounts)   been   affected  by  any
        extraordinary,  exceptional or non-recurring item, by transactions of an
        unusual  nature or entered  into other than on normal  commercial  terms
        (including  any  pension  contribution  holiday  or any  rental or other
        outgoing  at below  market  rates) or by any other  matter  making  such
        profits or losses for a period unusually high or low.

6.6     The accounting records of the Company have been maintained in accordance
        with the requirements of section 221 CA 1985.

6.7     The Latest Management  Accounts of the Company have been prepared in the
        ordinary  course of business and, having regard to the purpose for which
        they  have been  prepared,  reflect  the  financial  performance  of the
        business of the Company for the period to which they respectively relate
        in a manner which is not materially misleading.

7       BUSINESS SINCE THE LATEST ACCOUNTS DATE

7.1     Since the Latest Accounts Date:

        7.1.1   the  Company has  carried on its  business  in the usual  course
                without any  interruption or alteration in the nature,  scope or
                manner  of its  business  and so as to  maintain  it as a  going
                concern;

        7.1.2   there has been no material  adverse  change in the  financial or
                trading  position of the Company  and, so far as the  Warrantors
                are aware,  there exists no fact,  matter or  circumstance  that
                could give rise to the same;

                                       58



        7.1.3   no  material  adverse  change  has  occurred  in the  assets and
                liabilities  shown in the Latest  Accounts and there has been no
                reduction in the value of the net tangible assets of the Company
                on the basis of the valuations used in the Latest Accounts;

        7.1.4   the  Company  has not  acquired  or  disposed  of nor  agreed to
                acquire  or  dispose  of any  material  assets  nor  assumed  or
                incurred or agreed to assume or incur any  material  liabilities
                (including contingent  liabilities) other than in, in each case,
                the usual course of business;

        7.1.5   the  Company  has  not  made  or  agreed  to  make  any  capital
                expenditure  and no commitments  involving  capital  expenditure
                have been entered into or agreed to be entered into, in total in
                excess of (pound)50,000;

        7.1.6   the  Company  has  not  declared,  paid or  made a  dividend  or
                distribution except as provided in the Latest Accounts;

        7.1.7   the Company has not made a payment  which will not be deductible
                for  corporation  tax purposes either in computing the Company's
                trading  profits or in computing the  corporation tax chargeable
                on the Company  which alone or when  aggregated  with other such
                payments  made  since  the  Latest  Accounts  Date  exceeds  the
                aggregate of non-deductible  payments made over a similar period
                during the currency of the Latest Accounts;

        7.1.8   the Company has not changed its accounting reference period;

        7.1.9   no resolution of the  shareholders  the Company has been passed;
                and

        7.1.10  the Company has not created,  allotted, issued, acquired, repaid
                or redeemed  share or loan capital or granted any options in any
                share   capital  or  made  any  agreement  or   arrangement   or
                undertaking to do any of those things.

8       BORROWINGS AND BANK FACILITIES

8.1     The  Company has not  exceeded  any limit on the amount it may borrow or
        raise in any agreement or  arrangement  with its lenders or providers of
        credit to it (whether under any overdraft facility or otherwise). So far
        as the Warrantors  are aware,  the Company is not in breach of the terms
        of any other such  facilities and the total amount borrowed or raised by
        the Company from whatsoever source does not exceed any limitation on its
        borrowings  and other  powers  contained  in the  Company's  articles of
        association  or in any  debenture  or  loan  stock  deed  or  any  other
        instrument or agreement to which the Company is a party.

8.2     Full  details  of  all  overdrafts,   loans,  credit  facilities,  other
        borrowings or  indebtedness  in the nature of borrowings  outstanding or
        available to the Company are contained in the  Disclosure  Letter and so
        far as the Warrantors are aware,  none of the Vendors or the Company has
        done or omitted  to do  anything  whereby  the  continuance  of any such
        facilities  in full force and effect might be affected or  prejudiced or
        the availability thereof terminated.

                                       59



8.3     A statement of all the bank accounts of the Company and of the credit or
        debit  balances  on such  accounts as at a date not more than seven days
        before the date of  Completion  is  attached to the  Disclosure  Letter.
        Since  such  statement  there  have  been no  payments  out of any  such
        accounts except for routine payments in the usual course of business and
        the balances on current account are not now substantially different from
        the balance shown on such statements.

8.4     The  Company  has not  received  notice  from any lender or  provider of
        credit to it (whether  under any  overdraft,  loan,  credit  acceptance,
        bill,  discounting,  note  purchase or other  agreement or  arrangement)
        requiring payment thereof cancelling the availability thereof or placing
        any  indebtedness  thereunder  (in each  case) on  demand  or  otherwise
        altering  to the  disadvantage  of the  Company,  the  terms of any such
        agreement or arrangement and, so far as the Warrantors are aware,  there
        are no circumstances  which would now (or which could with the giving of
        notice,  lapse of time, the making of any  determination,  or otherwise)
        give rise to any such notice.

8.5     The  Company  has not  received  notice of  enforcement  or  demand  for
        payment, or intention to enforce or make demand for payment,  from or of
        steps being taken to enforce or to demand payment under,  any debenture,
        mortgage,  charge,  guarantee,  indemnity,  letter of  comfort  or other
        security or assurance for payment.

8.6     The  Company has no  outstanding  loan  capital nor has it factored  its
        debts.

8.7     The Company has not created or agreed to create any Security Interest.

8.8     The Company has not engaged in any  borrowing or financing  not required
        to be shown or reflected in the statutory accounts of the Company.

9       GRANTS

9.1     Full particulars of all material grants, allowances, subsidies, loans or
        financial  assistance  ("grants")  paid or pledged to the Company during
        the last two years by any person are set out in the Disclosure Letter.

9.2     There  are no  facts or  circumstances  (including  as a  result  of the
        entering into of this Agreement) of which the Warrantors are aware which
        could reasonably be expected to entitle early repayment of or refusal of
        an application for, a grant in whole or in part.

10      GUARANTEES AND INDEMNITIES

10.1    There  is  no  outstanding  guarantee,  indemnity,  letter  of  comfort,
        assurance for payment, mortgage, charge, debenture or other agreement or
        arrangement  to secure or incur a  financial  or other  obligation  with
        respect to its or another  person's  obligation given for the benefit of
        the  Company or by the  Company  other than as  disclosed  in the Latest
        Accounts.

                                       60



11      DEBTORS AND CREDITORS

11.1    To the best of the Warrantors'  knowledge,  information and belief, each
        debt now owed to the Company (less the amount of any specific  provision
        or reserve  specifically  disclosed in the Disclosure Letter, the Latest
        Accounts or the Latest  Management  Accounts and  determined on the same
        basis as that applied in the Latest Accounts) will realise its full face
        value and be good and collectable in the usual course of business.  None
        of such debts is subject to any  counterclaim  or set-off (except to the
        extent of any such provision or reserve).

11.2    No debt included in the Latest Accounts,  the Latest Management Accounts
        or the  Company's  accounting  records  (for the  period  covered by the
        Latest  Accounts or Latest  Management  Accounts)  has been realised for
        materially  less than its book  value in the Latest  Accounts  or Latest
        Management  Accounts or has been deferred or  subordinated to any extent
        nor has  been  released  or to the  best of the  Warrantors'  knowledge,
        information and belief, is irrecoverable to any extent.

11.3    No debt now owed to the Company is overdue by more than 12 weeks (except
        to the extent of any  provision or reserve  disclosed in the  Disclosure
        Letter, the Latest Accounts or the Latest Management Accounts).

11.4    The Company has paid its creditors within the times agreed with them. No
        debt owing by it has been due for more than 30 days.

11.5    No single  debtor  owes to the  Company  an  amount  which  exceeds,  in
        aggregate, 15 per cent of the total of the debts owing to the Company at
        the date of this Agreement.

11.6    To the best of the Warrantors'  knowledge,  information and belief,  the
        attitudes and actions of customers,  suppliers and employees with regard
        to  the  Company  will  not  be  materially  adversely  affected  by the
        completion by the Purchaser of the purchase of the Shares.

12      TRADING AND CONTRACTUAL ARRANGEMENTS

12.1    The Company is not a party to nor is liable under:

        12.1.1  any  partnership,  joint  venture,  European  Economic  Interest
                Grouping  or  consortium,  association  (other  than a bona fide
                trade  association) or any agreement for sharing  commissions or
                other income;

        12.1.2  a distributorship,  agency, franchise or management agreement or
                arrangement;

12.2    The Company is not a party to nor is liable under:

        12.2.1  any agreement or arrangement which, so far as the Warrantors are
                aware, is liable to be terminated by another party or, so far as
                the Warrantors  are aware,  under which rights of any person are
                liable to arise or be  affected as a result of any change in the
                control, management or shareholders of the Company;

                                       61



        12.2.2  any contract of a long-term nature (that is to say,  unlikely to
                have been fully  performed,  in accordance with its terms,  more
                than twelve months after the date on which it was entered into);

        12.2.3  any  agreement  or  arrangement  of a loss making  nature to any
                material  extent  (that is to say,  now  known to be  likely  to
                result in a material loss on completion of performance);

        12.2.4  any agreement or arrangement  limiting or excluding its right to
                do  business  or use or  exploit  any  of its  assets  including
                restrictions or  prohibitions  on competing in any  geographical
                area or in any field of activity or with any person;

        12.2.5  any agreement or  arrangement  of an unusual  nature or which is
                not entered into on an arm's length basis or in the usual course
                of the Company's business;

        12.2.6  a sale or purchase, option or purchase agreement, arrangement or
                obligation affecting an asset owned, occupied, possessed or used
                by the Company or by which the Company is bound;

        12.2.7  any agreement or arrangement which involves payment by reference
                to fluctuations in the index of retail prices or any other index
                or in the rate of exchange for any currency.

12.3    So far as the Warrantors are aware, no agreement or arrangement to which
        the Company is a party or is liable under  (including  specifically  but
        without  limitation  the Key  Agreements),  is invalid and so far as the
        Warrantors  are aware  there are no grounds  upon which any other  party
        thereto may  terminate,  rescind,  avoid or repudiate  such agreement or
        arrangement.

12.4    Neither the Company nor any party with whom the Company has entered into
        an  agreement  or  arrangement  (including  without  limitation  the Key
        Agreements)  has given notice of  termination  or sought to repudiate or
        disclaim the agreement or  arrangement  or taken any action or failed to
        take any action  inconsistent  with the continuance of any agreement nor
        arrangement.

12.5    The Company has no outstanding  bid,  tender,  sale or service  proposal
        which, if accepted, would give rise to a legally binding obligation upon
        the Company.

12.6    Neither the Company nor (so far as the  Warrantors  are aware) any party
        to an agreement or  arrangement  (including  any of the Key  Agreements)
        with the Company, is in violation or breach of, or in default under, any
        such  agreement  or  arrangement,  and to the  best  of the  Warrantors'
        knowledge  there  are no facts or  circumstances  likely to give rise to
        such a violation, breach or default.

12.7

        12.7.1  The  execution,  delivery  and  performance  of  each of the Key
                Agreements  and the Terminated Key Agreements by the Company was
                duly and validly authorised by all necessary corporate action on
                the part of the Company. Each of the Key Agreements was duly and
                validly executed

                                       62



                and delivered by the Company and, so far as the  Warrantors  are
                aware,  each of the other  parties  thereto  and each of the Key
                Agreements  constitutes legal, valid and binding  obligations on
                each of the Company and, so far as the Warrantors are aware, the
                other the relevant parties.

        12.7.2  The  execution  and  delivery  of this  Agreement  and the other
                Transaction  Documents by each of the Vendors, the Company, PPSL
                and/or  Purchaser do not, and the  performance of this Agreement
                and the  other  Transaction  Documents  by each of the same will
                not,  result in any breach of, or  constitute  a default  (or an
                event that with  notice or lapse of time or both would  become a
                default) under, or, so far as the Warrantors are aware,  entitle
                any party to any Key Agreement to rights and privileges  that it
                was not entitled to receive  immediately  before this  Agreement
                (or the other  Transaction  Documents) were executed,  or create
                any  obligation  on the part of the Company that it did not have
                immediately  before  this  Agreement  and the other  Transaction
                Documents were  executed,  or so far as the Warrantors are aware
                give to any such  party any  rights of  termination,  amendment,
                acceleration or cancellation,  or require the consent,  approval
                or waiver of any party, in respect of any Key Agreement.

        12.7.3  Each of the Key Agreements is in full force and effect.

        12.7.4  No consent,  approval or waiver of any third party was  required
                to be obtained by the Company or (so far as the  Warrantors  are
                aware) any other party to any Key  Agreement or  Terminated  Key
                Agreement  in  connection   with  the  execution,   delivery  or
                performance  of the Key  Agreements or Terminated Key Agreements
                which consent, approval or waiver was not so obtained.

12.8    None of the  records,  systems,  data or  information  of the Company is
        recorded,  stored,  maintained,  operated or otherwise  wholly or partly
        dependent  on  or  held  or  accessible  by  any  means   (including  an
        electronic,  mechanical or  photographic  process  computerised  or not)
        which is not under the  exclusive  ownership  and direct  control of the
        Company.

12.9    True and complete  copies of each and every Key  Agreement or Terminated
        Key Agreement  (or, to the extent there are no written terms, a true and
        complete  summary of the terms  thereof)  are annexed to the  Disclosure
        Letter.

12.10   The  Company  is not a party to nor is  liable  under  any  distribution
        and/or  licensing   agreements  or  arrangements   other  than  the  Key
        Agreements.

12.11   True and complete copies of each and every sale agreement or arrangement
        (or,  to the extent  there are no  written  terms,  a true and  complete
        summary of the terms thereof) to which the Company has been party in the
        last  two  years  in  respect  of  which   consideration  in  excess  of
        (pound)100,000 was payable to the Company are attached to the Disclosure
        Letter.

12.12   Neither the Company nor (so far as the  Warrantors  are aware) any other
        party to the Terminated  Key Agreement was, prior to the  termination of
        such

                                       63



        agreements,  in  violation or breach of, or in default  under,  any such
        agreement  and to the best of the  Warrantor's  knowledge at the time of
        termination, there were no facts or circumstances likely to give rise to
        such a violation,  breach or default or any grounds upon which any party
        to the  Terminated  key  Agreements  could have  terminated,  rescinded,
        waived or repudiated any such agreement.

12.13   The  Terminated  Key  Agreements   have  been  validly  and  effectively
        terminated  and  no  party  has  any  continuing   rights,   privileges,
        obligations or liabilities under any such agreement.

13      COMPETITION

13.1    The  Company  is not and  has  not  been a  party  to any  agreement  or
        concerted practice:

        13.1.1  which  infringes  article  81(1)  of the  Treaty  of  Rome  (the
                "TREATY") or the Chapter I prohibition under the Competition Act
                1998 (the "1998 ACT")  (other than one which is exempt  pursuant
                to a Commission  decision in application of article 81(3) of the
                Treaty or pursuant to an exemption by category  enacted pursuant
                to article 83 of the Treaty or in respect of which an  exemption
                under  sections 4, 6 or 10 of the 1998 Act applies,  as the case
                may be);

        13.1.2  which had prior to 1 May 2004 been notified to the Commission of
                the European  Communities or EFTA Surveillance  Authority for an
                exemption  under article 81(3) of the Treaty or article 53(3) of
                the  Agreement on the European  Economic Area or pursuant to any
                exemption by category or for which an application  has been made
                to the Commission or EFTA Surveillance  Authority for a negative
                clearance  under  articles  81 or 82 of the  Treaty  of  Rome or
                Articles 53 and 54 of the  Agreement  on the  European  Economic
                Area or  which  had  prior to 1 May 2004  been  notified  to the
                Office of Fair  Trading  (or prior to June 2003 to the  Director
                General of Fair Trading (the "DIRECTOR")) under sections 13, 14,
                21 or 22 of the 1998 Act; or

        13.1.3  which is prohibited  by  competition  or  anti-trust  law in any
                jurisdiction or which has been notified to any other competition
                or anti-trust authority for guidance or a decision.

13.2    No action,  practice  or course of  conduct  now or  previously  done or
        carried on by the  Company and no  agreement  to which the Company is or
        was a party or any part of any such agreement:

        13.2.1  causes or caused the Seller to breach  article 82 of the Treaty,
                article 54 of the Agreement on the European  Economic  Area, the
                Chapter II prohibition  under the 1998 Act or any  anti-monopoly
                legislation or regulations in any other jurisdiction;

        13.2.2  has  been  investigated  by or,  prior to 1 May  2004,  has been
                notified to the Office of Fair Trading (or prior to June 2003 to
                the Director) for

                                       64



                guidance or a decision in respect of the Chapter II  prohibition
                under the 1998 Act; or

        13.2.3  has been notified to or  investigated  by any other  competition
                authority  in  relation  to the  abuse or  potential  abuse of a
                dominant or monopoly position.

13.3    The Company has not at any time  received nor (so far as the  Warrantors
        are aware) has the Company any  grounds for  believing  that the Company
        may receive any  communication or request for information with reference
        to any  aspect  of the  Company's  activities  from  the  Director,  the
        Competition   Appeals  Tribunal,   the  Office  of  Fair  Trading,   the
        Competition  Commission,  the Secretary of State for Trade and Industry,
        the Commission of the European Communities,  EFTA Surveillance Authority
        or  from  any  other  person  in any  jurisdiction  whose  task it is to
        investigate,  report or decide  upon  matters  relating  to  monopolies,
        mergers or  anti-competitive  agreements or practices.  Nothing has been
        done by the Company  which the Company has been notified has been or (so
        far as the  Warrantors  are aware)  might be the  subject of any report,
        decision,  order,  regulation,  judgment or  injunction  made,  taken or
        obtained by any of such persons.

13.4    The  Company  has not  given an  undertaking  or  written  assurance  to
        (legally  binding or not) and is not  subject to any order,  decision or
        administrative letter from, a governmental  authority or an authority of
        the  European  Communities  or  European  Economic  Area  under the Fair
        Trading Act 1973, the 1998 Act, the Enterprise Act 2002, the Treaty, the
        Agreement  on the  European  Economic  Area or  other  statute  or legal
        instrument of the United Kingdom or any other jurisdiction.

13.5    The Company has never  received nor (so far as the Warrantors are aware)
        is the Company  expecting  to receive any aid from a member state of the
        European  Community or through state  resources  which is not compatible
        with the common market having regard to article 87 of the Treaty.

13.6    So far as the Warrantors are aware,  no director,  officer,  employee or
        agent of the Company has engaged in any conduct  falling  within section
        188  of  the  Enterprise  Act  2002  or  any  other  legislation  in any
        jurisdiction that criminalises anti-competitive behaviour.

14      INTELLECTUAL PROPERTY RIGHTS

14.1    Each of the Intellectual Property Rights is:

        14.1.1  valid and  enforceable  and, so far as the Warrantors are aware,
                nothing  has  been  done or  omitted  to be done by which it may
                cease to be valid and  enforceable  or  affect  the right of the
                Company to use the same in its business; and

        14.1.2  legally  and  beneficially  owned by the Company  alone  (except
                where  it  falls   within   paragraph   14.3),   free  from  any
                encumbrance, restriction on use or disclosure obligations.

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14.2    The  Disclosure  Letter  contains  details  of  all  of  the  registered
        Intellectual  Property  Rights in  respect  of which the  Company is the
        registered  owner or  applicant  for  registration.  No notice  has been
        received  by the  Company of any  dispute,  claim or  opposition  from a
        person  (including  an employee of the  Company) as to title,  validity,
        enforceability,  entitlement  or otherwise and so far as the  Warrantors
        are aware there are no  circumstances in existence which would give rise
        to any such dispute, claim or opposition.

14.3    All  agreements  relating  to the  use by the  Company  of  Intellectual
        Property  (including  any  Intellectual  Property in software)  owned by
        another  person  are listed in the  Disclosure  Letter.  The  agreements
        relating to that Intellectual Property contain all the terms relative to
        the use by the Company of the same.

14.4    So far as the Warrantors are aware no party to an agreement  relating to
        the use:

        14.4.1  by the Company of Intellectual Property owned by another person;
                or

        14.4.2  of any  Intellectual  Property  Rights  owned by the  Company by
                another person,

        is, or has at any time been, in breach of the  agreement  and, so far as
        the Warrantors are aware, no  circumstances  exist which would give rise
        to any  breach  of any such  agreement  or to any such  agreement  being
        terminated,  suspended,  varied or revoked without the Company's consent
        (other than termination without cause upon notice in accordance with the
        terms of the agreement).

14.5    The  Know-How  is  confidential  and has not been  disclosed  nor is the
        Company obliged to disclose it, to any person in whole or in part (other
        than  to   employees   of  the  Company  in   circumstances   where  the
        confidentiality  of the Know How has been drawn to their  attention  and
        steps taken to preserve such confidentiality) and there is no Claim that
        has been,  or so far as the  Warrantors  are  aware,  can be made by any
        person  alleging that the Know-How has been  disclosed to the Company in
        circumstances amounting to a breach of confidence.

14.6    All Know-How is adequately documented to enable the Purchaser to acquire
        and retain its full benefit.

14.7    The Company has not granted and is not obliged to grant any licences of,
        nor are there any  subsisting  agreements  under  which the  Company has
        granted to any person, any right, interest,  assignment or consent under
        or in connection with the Intellectual Property Rights or the Know-How.

14.8    So far as the Warrantors are aware,  none of the processes,  products or
        activities  of the  business of the Company  infringes  any right of any
        other  person  relating  to   Intellectual   Property  or  involves  the
        unlicensed use of information  confidential  to any person or gives rise
        to a liability  for any royalty or similar  payment other than by virtue
        of an agreement relating to licensed Intellectual Property listed in the
        Disclosure Letter.

14.9    The Company does not trade under any name other than its full  corporate
        name.

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15      TITLE AND CONDITION OF ASSETS

15.1    Except  for assets  disposed  of by the  Company in the usual  course of
        trading,  the Company is the legal and beneficial  owner of and has good
        title to all assets included in the Latest Accounts and all assets which
        have been acquired by the Company since the Latest Accounts Date, all of
        which  assets  are in the  Company's  possession  or under its  control,
        situated in the United Kingdom and free from any Security Interest. Such
        assets  comprise all material  assets now used in the Business and which
        are necessary for the Company to carry on the Business effectively.

15.2    All plant and machinery (including fixed plant and machinery),  vehicles
        and computer,  office and other  equipment  owned or used by the Company
        are in a  condition  commensurate  with their age and fair wear and tear
        and  are  in  working  order  and  have  been   regularly  and  properly
        maintained;  and, so far as the Warrantors are aware, none is dangerous,
        or, so far as the Warrantors are aware, in need of repair or replacement
        in order to continue  in  operation  the  business of the Company in the
        ordinary course for the period of six months following Completion, where
        such repair or replacement would cost in excess of (pound)10,000.

15.3    There are maintenance contracts with independent  specialist contractors
        in respect of all assets of the  Company  for which it is normal to have
        maintenance  contracts and in respect of all assets which the Company is
        obliged to maintain or repair under a lease or similar  agreement.  Such
        assets  have  been  regularly   maintained  in  accordance  with  safety
        regulations  required  to be  observed  in  relation  to  them  and  the
        provisions of any applicable leasing or similar agreement.

15.4    The  Company's  asset  register  (a copy of  which  is  attached  to the
        Disclosure  Letter) is a complete  and  accurate  record in all material
        respects of the fixed assets owned or used by it.

15.5    Full  details  of all hire,  hire  purchase,  credit  sale,  conditional
        purchase,  rental and similar agreements and arrangements granted by the
        Company or to which its is subject where the annual  payments  under any
        such agreement or arrangement is more than  (pound)50,000  per annum (or
        the total annual  payments under all such  agreements  and  arrangements
        exceed  (pound)50,000)  are contained in the Disclosure Letter (together
        with a  schedule  listing  the  assets  subject  to  such  agreement  or
        arrangement)  and  none of the  Warrantors  or the  Company  has done or
        omitted to do anything whereby such agreements or arrangements  might be
        affected or prejudiced or the availability thereof terminated.

15.6    The  Company  has not  agreed to  acquire  any  asset on terms  that the
        property in such asset does not pass to it until full payment is made.

15.7    The Company's  stock is in good  condition and so far as the  Warrantors
        are aware,  saleable in the usual course of its  business in  accordance
        with the Company's  current  price list without any rebate,  discount or
        allowances (other than normal rebates,  discounts or allowances  granted
        to customers).

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15.8    So far as the  Warrantors  are aware,  the Company  has not  supplied or
        agreed to supply defective or unsafe goods or goods which fail to comply
        with their terms of sale.

15.9    No goods in a state ready for supply by the  Company,  are so far as the
        Warrantors  are aware,  defective  or unsafe or will fail to comply with
        terms of sale the same as  terms  of sale on which  similar  goods  have
        previously been supplied by the Company.

15.10   The Company's level of stock is reasonable  having regard to current and
        anticipated demand.

15.11   The work in progress  of the  Company is adequate to maintain  cash flow
        and  profitability  at  a  level  disclosed  in  the  Latest  Management
        Accounts.

16      TITLE DEEDS

16.1    All  documents  which in any way affect the right,  title or interest of
        the Company in or to any of its property, undertakings or assets and all
        agreements to which the Company is a party are in the  possession of the
        Company and are properly stamped (if applicable).

17      VENDORS' ARRANGEMENTS

17.1    There is no contract or  arrangement  between the Company and any Vendor
        or a director of the Company or any person  connected with any Vendor or
        such director pursuant to which any indebtedness  (actual or contingent)
        is outstanding.

17.2    No Vendor and, so far as the Warrantors are aware,  no person  connected
        with any Vendor has any  interest,  direct or indirect,  in any business
        which  competes or has competed  with any business now carried on by the
        Company or intends to acquire any such interest.

17.3    No Vendor is  entitled  to any claim  against  the  Company,  any of its
        officers, employees,  principal customers or suppliers and no Vendor has
        assigned  to any third  party the  benefit  of any claim to which he was
        previously entitled.

18      OFFICERS AND EMPLOYEES

18.1    Those  persons  named  as such in the  Disclosure  Letter  are the  only
        directors of the Company and the secretary of the Company, respectively.
        The full  terms of the  contract  of  employment  or other  contract  of
        engagement  between  the  Company  and  any of  its  directors  and  the
        secretary of the Company are annexed to the Disclosure  Letter  together
        with details of any payment or benefits  (whether or not legally binding
        on the Company) which is not included in the written terms of employment
        or engagement. The Company is not a party to any consultancy contract.

18.2    No  person  is or has been a shadow  director  (within  the  meaning  of
        section 741 of the Act) of the Company.

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18.3    No person is employed by the Company or retained on a consultancy  basis
        nor has any  person  been so  employed  or  retained  since  the date of
        incorporation  of the Company and, so far as the  Warrantors  are aware,
        there is no commitment to do so.

19      PENSIONS

19.1    The  Company  has no  legal  or  moral  obligation  to pay any  pension,
        gratuity,  superannuation allowance, death benefit,  retirement gratuity
        or like benefit or make any other payment after  disability,  retirement
        or death or contribute to any life  assurance,  on behalf of the Company
        or for any  director  or any person who is now or has been an officer or
        employee  of  the  Company  or  any  predecessor  in  business  (or  the
        widow/widower or dependant of any such person) and is not a party to any
        scheme or arrangement  having as its purpose the making of such payments
        or the provision of such benefits.

20      INSURANCES

20.1    All the assets of the Company  which are of an insurable  nature have at
        all material times been and are at the date of this Agreement insured in
        amounts  reasonably  regarded as  adequate  against  each risk  normally
        insured against by companies  operating the type of business operated by
        the Company or owning property of a similar nature.

20.2    The  Disclosure  Letter  contains   particulars  of  all  insurance  and
        indemnity  policies  maintained  by the Company and  currently  in force
        ("THE POLICIES"). In respect of all such Policies:

        20.2.1  all  premiums  have  been  duly  paid to date  and so far as the
                Warrantors  are  aware  the  Company  has not done  anything  or
                omitted to do  anything  which is likely to result in a material
                increase in the premium payable under any such policy;

        20.2.2  no notice has been  received by the  Company  that any Policy is
                not valid or  enforceable  or void or voidable and so far as the
                Warrantors  are  aware  the  Company  has not done  anything  or
                omitted to do anything which might make any of the policies void
                or voidable or which might  prejudice the ability to effect such
                insurance in the future;

        20.2.3  in the Warrantors'  reasonable belief (without  enquiry),  there
                are no special or unusual terms or restrictions;

        20.2.4  no claim exceeding (pound)5,000 is outstanding and so far as the
                Warrantors are aware no facts or  circumstances  exist which may
                give rise to any such claim and no insurer has disputed or given
                an indication  that it intends to refuse to meet any outstanding
                claim to any extent; and

        20.2.5  none of the  Policies  contain  any  provisions  as to change of
                control or ownership of the insured.

20.3    No insurer  has ever  cancelled  or refused  to accept or  continue  any
        insurance in relation to the Company.

                                       69



21      COMPLIANCE WITH LAWS

21.1    The  Company  and  (so  far as the  Warrantors  are  aware)  each of its
        affiliates,  sub-contractors,  distributors  and licensees has conducted
        its  business  and dealt with its  assets in all  material  respects  in
        accordance with all applicable laws and regulations.

21.2    The  Company  has not at any time  received  any notice or  request  for
        information from either the Data Protection  Registrar or a data subject
        in  relation  to  compliance  with data  protection  legislation  by the
        Company and has at all relevant times complied with the Data  Protection
        Act 1998.

22      LITIGATION, CLAIMS AND INVESTIGATIONS

22.1    Neither  the  Company,  nor any person for whose  acts or  defaults  the
        Company may be vicariously  liable,  is engaged or has during the period
        since  its  incorporation   been  engaged,   in  any  civil,   criminal,
        arbitration,  administrative,  prosecution or other legal proceedings or
        in  any  other   proceedings   or  hearings   before  any  statutory  or
        governmental body,  department,  board or agency in any jurisdiction and
        so far as the  Warrantors  are aware none is pending or threatened by or
        against the Company or such person.  So far as the  Warrantors are aware
        there are no facts or  circumstances  which may give rise to any  civil,
        criminal,  arbitration,  administrative,   prosecution  or  other  legal
        proceedings  or other  proceedings  or hearings  before any statutory or
        governmental body, department, board or agency in any jurisdiction being
        commenced  by or  against  the  Company,  or a person  for whose acts or
        defaults the Company may be vicariously liable.  Proceedings referred to
        in this  paragraph  24.1 include,  without  limitation,  proceedings  in
        respect  of death or  injury to any  person  as a result of any  product
        manufactured or supplied by the Company.

22.2    None of the officers of the Company is being prosecuted for any criminal
        offence, there are no such prosecutions pending or threatened and so far
        as the  Warrantors are aware there are no facts or  circumstances  which
        may give rise to any such prosecution.

22.3    There is no  outstanding  judgment,  order,  decree,  arbitral  award or
        decision of a court, tribunal, arbitrator,  governmental agency or other
        regulatory body in any jurisdiction against the Company or so far as the
        Warrantors are aware a person for whose acts or defaults the Company may
        be vicarious  liable.  The Company is not a party to any  undertaking or
        assurance given to any court, tribunal, arbitrator,  governmental agency
        or other regulatory body in any jurisdiction which is still in force. So
        far as the  Warrantors  are aware  there  are no facts or  circumstances
        which in the reasonable  opinion of the Warrantors are on the balance of
        probabilities  likely to result in the Company  becoming  subject to any
        such  order,  judgment,  decree,  arbitral  award or  decision  or being
        required to be a party to any such undertaking or assurance.

22.4    No notice has been received that there is or has been any  investigation
        or enquiry of or disciplinary  proceedings made against,  the Company or
        any  of  its  officers  or  employees,   in  any   jurisdiction  by  any
        governmental  or other body,  and so far as the  Warrantors are aware no
        such investigation, enquiry or

                                       70



        disciplinary  proceedings  are pending or threatened  and, so far as the
        Warrantors are aware there are no facts or circumstances  which may give
        rise to such investigation, enquiry or proceedings.

23      GROUP COMPANIES

23.1    The Company has no and has never had any subsidiary undertakings and has
        never had any legal or  beneficial  interest  in the  shares of any body
        corporate and has not agreed to acquire any such shares.

23.2    The  Company  does not have a branch,  agency or place of  business or a
        permanent  establishment  (as that expression is defined in the relevant
        double taxation treaty) outside the United Kingdom.

24      POWERS OF ATTORNEY

24.1    The  Company  has not  given a power  of  attorney  or  other  authority
        (express,  implied or  ostensible)  by which a person may enter into any
        contract,  arrangement  or  obligation  on its  behalf  (other  than any
        authority  to an  executive  director  or an  employee  to enter into an
        agreement in the usual course of that person's duties).

25      COMMISSION

25.1    No person is entitled to receive  from the  Company  any  finder's  fee,
        brokerage or other  commission in connection with the acquisition of the
        Shares under this Agreement.

26      INSOLVENCY

26.1    No receiver or  administrative  receiver has been appointed of the whole
        or any part of the assets or undertaking of the Company.

26.2    No petition has been presented,  order made or resolution passed for the
        winding-up  of the  Company  or for  the  appointment  of a  provisional
        liquidator to the Company and no  administration  order has been made in
        relation  to the  Company  and no  petition  for such an order  has been
        presented.

26.3    No proposal has been made for a voluntary  arrangement  under  section 1
        Insolvency  Act  1986 nor is in the  contemplation  of the  Company.  No
        compromise or  arrangement  has been  proposed,  agreed to or sanctioned
        under section 425 of the Act in respect of the Company.

26.4    The Company has not stopped  payment to its  creditors  as they fall due
        nor is it  insolvent  or unable to pay its debts  within the  meaning of
        section 123 Insolvency Act 1986.

26.5    No  unsatisfied  judgement  or court  order is  outstanding  against the
        Company.

26.6    No distress,  execution or other  process has been levied on an asset of
        the Company.

                                       71



26.7    No action is being taken by the  Registrar  of  Companies  to strike the
        Company off the register under section 652 of the Act.

26.8    The Company has not at any time during the two years  before the date of
        this  Agreement  entered  into  a  transaction  with  any  person  at an
        undervalue  (as referred to in section  238(4)  Insolvency  Act 1986) or
        been given a preference by any person (as referred to in section  239(4)
        Insolvency Act 1986).

27      PROPERTIES

        The Company does not have any interest in or over any  property,  nor is
        there any agreement for sale or other  disposal or commitment to dispose
        or grant any interest, lease, tenancy, licence or other right in or over
        any property. The Company has not at any time acquired, disposed of, had
        vested in it, guaranteed or entered into any other commitment in respect
        of any freehold or leasehold property.

28      ENVIRONMENTAL MATTERS

28.1    In this schedule the following words have the following meanings:

        "AUTHORISATION"  means  any  authorisation,  licence,  consent,  permit,
        registration, waiver, order, exemption, reporting or notice requirement,
        certificate of compliance  and any other  approval  obtained or required
        under  any  Environmental  Law  necessary  for  the  carrying  on of the
        Business;

        "ENVIRONMENT" means air, groundwater,  surface waters (including brooks,
        streams,  canals, lakes, rivers,  territorial and coastal waters), water
        in drains and sewers,  land,  soil and subsurface  strata and all living
        organisms,  ecosystems  and man-made and natural  structures to be found
        in, on or under  each of the  foregoing.  Air  includes  the air  within
        buildings, and the air within other natural or man-made structures above
        or below ground;

        "ENVIRONMENTAL LAW" means all European Community  legislation,  national
        and local statutes and other laws  concerning  Environmental  Matters in
        force  at the date of  Completion,  including  the  common  law,  rules,
        regulations,  by-laws, codes of practice, circulars, statutory guidance,
        guidance   notes  and  the  like  made   thereunder;   and  judicial  or
        administrative  interpretation of each of the foregoing but only insofar
        as the same are legally binding;

        "ENVIRONMENTAL  MATTERS"  means all matters  relating to human health or
        the Environment  including  discharges,  emissions,  releases,  escapes,
        spills, leaks or leaching into, onto or under land, air or water; Waste;
        contamination;   nuisance;  noise;  heat;  vibration;  the  manufacture,
        processing, use, possession,  handling,  treatment,  storage, labelling,
        recovery, recycling,  transport and disposal of any Hazardous Substance;
        nature conservation and health and safety;

        "HAZARDOUS SUBSTANCE" means any natural or artificial substance (whether
        solid, liquid, gas, vapour, noise, electromagnetic radiation or ionising
        radiation, and whether alone or in combination with any other substance)
        that is capable of

                                       72



        causing  significant  harm to  people  or that  may  have a  significant
        adverse affect the Environment; and

        "WASTE"  means  industrial,  commercial or domestic  waste,  radioactive
        waste, agricultural waste, mineral waste,  decommissioned explosives and
        packaging waste including any Hazardous  Substance or any substance that
        is classified as dangerous under Environmental Law.

28.2    The  replies  to written  enquiries  made by the  Purchaser's  Attorneys
        concerning  any  Environmental  Matters have been given after making due
        and diligent enquiry and are true and accurate.

28.3    The  Company  has  not  entered  into  any  arrangement,   agreement  or
        understanding  with any  person  relating  to any  potential  or  actual
        contamination or pollution of the Environment.

        CONTAMINATION

28.4    To the best of the Vendors  knowledge no  contamination  or pollution of
        the  Environment  is or may be,  attributable  to the Company's  acts or
        omissions.

28.5    The Company has not received any written request,  written notification,
        notice or other written  communication  from any person  relating to any
        potential or actual contamination or pollution of the Environment or its
        potential  or  actual  remediation.  The  Vendors  are not  aware of any
        circumstances  that may give rise to the  receipt  of any such  request,
        notification, notice or other communication.

        AUTHORISATION AND COMPLIANCE

28.6    The Company has, and always has had, all  Authorisations  and is now and
        always has been in full  compliance with the terms and conditions of any
        Authorisation.

28.7    The Vendors  are not aware of any  circumstance  that would  require the
        Company to incur any material  capital  expenditure to comply fully with
        the terms and conditions of any  Authorisations  that it currently holds
        or will be required to hold under current  Environmental Laws, including
        but not limited to the  Pollution  Prevention  and Control  (England and
        Wales) Regulations 2000, as amended.

28.8    No  Authorisation  that the Company has or has had,  has been  modified,
        varied,  suspended or revoked and no  application  by the Company for an
        Authorisation or a modification to or variation of an Authorisation  has
        been refused.

28.9    The Company has not received any written request,  written notification,
        notice or other  written  communication  from any person that  requires,
        refers to the  possibility  of or  threatens,  modification,  variation,
        suspension or revocation  of any  Authorisation  and the Vendors are not
        aware of any  circumstance  that might  give rise to such  modification,
        variation, suspension or revocation.

28.10   The  Company is in full  compliance  and so far as the Vendors are aware
        always  has  fully   complied,   in  all  material   respects  with  all
        Environmental Laws.

                                       73



28.11   To the best of the Warrantors'  knowledge neither the Company nor any of
        its  directors  or officers  has  received  or, is likely to receive any
        formal written complaint or claim relating to any  Environmental  Matter
        from any person connected with or arising out of the Business.

28.12   Neither the Company nor any of its  directors  or officers  has received
        or, to the best of the Warrantors'  knowledge,  is likely to receive any
        notice,  order or other  formal  written  communication  from any person
        relating to any  Environmental  Matter  connected with or arising out of
        the Business and no civil or criminal  litigation  is pending or, to the
        best of the Warrantors' knowledge, threatened against the Company or any
        current or former  director or officer,  of the Company which relates to
        or arises out of any Environmental  Matter connected with or arising out
        of the Business.

        REPORTS

28.13   Copies of all environmental assessments, reports and audits commissioned
        by the Company and relating to the Business, and any property previously
        owned or occupied by the Company have been  disclosed  to the  Purchaser
        and all reasonable steps to comply with the recommendations contained in
        such assessments, reports and audits have been implemented.

28.14   Copies of all written  communications  from the Medicine Control Agency,
        Health &  Safety  Executive,  US Food & Drug  Administration  and  other
        regulatory  authorities,  health and  safety  action  plans,  health and
        safety policies,  health and safety risk assessment  reports and similar
        documents have been disclosed to the Purchaser.

                                       74



                                   SCHEDULE 4

                          Part 2 - The Representations
                          ----------------------------

1       The  Company has not  violated or breached  and is not in default of any
        terms of the Penn Pharmion Agreement.

2       So far as the  Warrantors  are aware,  Pharmion GmbH has not violated or
        breached,  and is not in  default  of,  any  of the  terms  of the  Penn
        Pharmion  Agreement and to the best of, the Warrantors'  knowledge there
        are no facts or  circumstances  likely to give rise to such a violation,
        breach or default.

3       The Company has not been notified by Pharmion  GmbH of the  termination,
        repudiation,  rescission,  avoidance or  disclaimer of the Penn Pharmion
        Agreement  by Pharmion and the Company has not  terminated,  repudiated,
        rescinded, avoided or disclaimed the Penn Pharmion Agreement, and so far
        as the  Warrantors  are aware,  there are no grounds upon which the Penn
        Pharmion Agreement may be terminated,  repudiated, rescinded, avoided or
        disclaimed by the Company or Pharmion.

4       So far  as  the  Warrantors  are  aware,  the  execution,  delivery  and
        performance  of this  Agreement and the other  Transaction  Documents to
        which  the  Company  is a party  will not  result in any  breach  of, or
        constitute  a default  (or an event that with notice or lapse of time or
        both would  become a default)  under,  the Penn  Pharmion  Agreement  or
        entitle  Pharmion to any rights and privileges  that it was not entitled
        to receive  immediately  before this Agreement and the other Transaction
        Documents  were  executed,  or create any  obligation on the part of the
        Company that it did not have  immediately  before this Agreement and the
        other Transaction Documents were executed, or give Pharmion any right of
        termination,  amendment,  acceleration or  cancellation,  or require the
        consent, approval or waiver of Pharmion.

                                       75



                                   SCHEDULE 5

                              Part 1 - The Vendors
                              --------------------

- ---------------------- --------------------- ------------------- ---------------
          (1)                   (2)                 (3)                 (4)
         NAME                 ADDRESS/           NUMBER AND          RELEVANT
                         REGISTERED OFFICE     CLASS OF SHARES      PROPORTION
                                                CURRENTLY HELD
- ---------------------- --------------------- ------------------- ---------------
Ken Caldicott           Pontefelin House           14,000 B            2.8
                        New Inn                ordinary shares
                        Pontypool
                        Gwent  NP4 0NY
- ---------------------- --------------------- ------------------- ---------------
Steve Evans             Ry-mels Villa              10,000 B             2
                        Station Road           ordinary shares
                        Waunlwyd
                        Ebbw Vale
                        NP23 6TN
- ---------------------- --------------------- ------------------- ---------------
Christopher Higgins     Cluny                      14,000 B            2.8
                        Knaresborough Road     ordinary shares
                        Harrogate
                        HG3 3QQ
- ---------------------- --------------------- ------------------- ---------------
Jeremy Hyde             South Riding               10,000 B             2
                        Shoppenhangers Road    ordinary shares
                        Maidenhead
                        Berkshire SL6 2PZ
- ---------------------- --------------------- ------------------- ---------------
Roger Spencer Jones     c/o Battle House           25,000 B             5
and Ann Jones as the    Battle                 ordinary shares
trustees of The Roger   Brecon
Jones Interest in       Powys
Possession Trust        LD3 9RW

- ---------------------- --------------------- ------------------- ---------------
Craig Rennie            Renwood                    90,000 B            18
                        Ellwood Road           ordinary shares
                        Beaconsfield              198,971 B
                        Bucks HP9 1EN         preference shares
- ---------------------- --------------------- ------------------- ---------------
Peter Skellon           Hillberry                   5,000 B             1
                        Blaenavon Road         ordinary shares
                        Govilon
                        Near Abergavenny
                        Gwent  NP7 9NY
- ---------------------- --------------------- ------------------- ---------------
Glyn Tonge              Whitefriars                5,000 B              1
                        Hawley Road            ordinary shares
                        Hawley
                        Surrey  GU17 9EL
- ---------------------- --------------------- ------------------- ---------------
Bryn Williams           15 Windsor House          18,667 B           3.7334
                        Castle Court           ordinary shares
                        Westgate Street
                        Cardiff  CF10 1DG
- ---------------------- --------------------- ------------------- ---------------

                                        76



- ---------------------- --------------------- ------------------- ---------------
Keren Winmill           Ivy Cottage               14,000 B             2.8
                        Llanfrynach            ordinary shares
                        Brecon
                        Powys  LD3 7AJ
- ---------------------- --------------------- ------------------- ---------------
David Henderson         10 Jasmine Close           11,833 B          2.3666
                        Worcester              ordinary shares
                        Worcestershire
                        WR5 3LU
- ---------------------- --------------------- ------------------- ---------------
Paul Thomas             49 Coed Camlas              7,500 B            1.5
                        New Inn                ordinary shares
                        Pontypool
                        Gwent
                        NP4 8RP
- ---------------------- --------------------- ------------------- ---------------
Barrington House        One South Place           275,000 A            55
Nominees Limited        London                 ordinary shares
Customers B             EC2M 2GT                 2,739,500 A
                                              preference shares
- ---------------------- --------------------- ------------------- ---------------
Total                   ___________               275,000 A           100
                                               ordinary shares
                                                  225,000 B
                                               ordinary shares
                                                 2,739,500 A
                                              preference shares
                                                  198,971 B
                                              preference shares
- ---------------------- --------------------- ------------------- ---------------

                                       77



                             Part 2 - The Warrantors
                             -----------------------

- --------------------------------------- ----------------------------------------
Ken Caldicott                           Pontefelin House
                                        New Inn
                                        Pontypool
                                        Gwent  NP4 0NY
- --------------------------------------- ----------------------------------------
Steve Evans                             Ry-mels Villa
                                        Station Road
                                        Waunlwyd
                                        Ebbw Vale
                                        NP23 6TN
- --------------------------------------- ----------------------------------------
Christopher Higgins                     Cluny
                                        Knaresborough Road
                                        Harrogate
                                        HG3 3QQ
- --------------------------------------- ----------------------------------------
Jeremy Hyde                             South Riding
                                        Shoppenhangers Road
                                        Maidenhead
                                        Berkshire SL6 2PZ
- --------------------------------------- ----------------------------------------
Roger Spencer Jones and                 Battle House
Ann Jones                               Battle
                                        Brecon
                                        Powys  LD3 9RW
- --------------------------------------- ----------------------------------------
Craig Rennie                            Renwood
                                        Ellwood Road
                                        Beaconsfield
                                        Bucks  HP9 1EN
- --------------------------------------- ----------------------------------------
Peter Skellon                           Hillberry
                                        Blaenavon Road
                                        Govilon
                                        Near Abergavenny
                                        Gwent  NP7 9NY
- --------------------------------------- ----------------------------------------
Glyn Tonge                              Whitefriars
                                        Hawley Road
                                        Hawley
                                        Surrey  GU17 9EL
- --------------------------------------- ----------------------------------------
Bryn Williams                           15 Windsor House
                                        Castle Court
                                        Westgate Street
                                        Cardiff  CF10 1DG
- --------------------------------------- ----------------------------------------
Keren Winmill                           Ivy Cottage
                                        Llanfrynach
                                        Brecon
                                        Powys  LD3 7AJ
- --------------------------------------- ----------------------------------------
David Henderson                         10 Jasmine Close
                                        Worcester
                                        Worcestershire
                                        WR5 3LU
- --------------------------------------- ----------------------------------------


                                       78



- --------------------------------------- ----------------------------------------
Paul Thomas                             49 Coed Camlas
                                        New Inn
                                        Pontypool
                                        Gwent NP4 8RP
- --------------------------------------- ----------------------------------------


                                       79



                                   SCHEDULE 6

                             The Completion Accounts
                             -----------------------

1       The first draft of the Completion Accounts shall be prepared by Penn and
        the Company at the direction of the Vendors'  Representatives  on behalf
        of the Vendors as soon as reasonably practicable and in any event within
        15 Business  Days of  Completion.  The  Purchaser  shall ensure that the
        Vendors  Representatives  and the Vendors'  Accountants  are allowed all
        reasonable access to all relevant information, personnel and records of,
        or under the  control of, the  Company  solely for that  purpose and the
        Vendors  shall not be in breach of their  obligations  pursuant  to this
        Schedule to the extent the Purchaser fails to ensure the same.

2       The Purchaser's  Accountants  shall, on the Completion Date, carry out a
        full  physical  stock-take  in respect of the stock of the Company as at
        the Completion Date.

3       The Vendors shall instruct:

        3.1     the  Vendors'  Accountants  to audit the profit and loss account
                and the Closing Balance Sheet (which form part of the Completion
                Accounts) as soon as  practicable  thereafter  (and in any event
                within 15 Business  Days of the  provision of first draft of the
                Completion Accounts pursuant to paragraph 1); and

        3.2     no later than 5 Business Days after completion of such audit the
                Vendors'   Representatives   to   prepare  a   statement   ("THE
                STATEMENT")  setting  out,  in their  opinion,  the  Closing Net
                Financial Position,  the Closing Debt and the Purchase Price and
                deliver a copy of the Statement and the  Completion  Accounts to
                the  Purchaser  and  the  Purchaser's   Solicitors  as  soon  as
                practicable thereafter.

4       The Completion Accounts shall be prepared:

        4.1     in accordance  with bases,  policies,  principles and procedures
                consistent  with those employed in the worked example set out in
                annexure 1 to this Agreement; and

        4.2     in the event that bases,  policies,  principles,  practices  and
                procedures  set  out in  annexure  1 to  this  Agreement  do not
                specify the  treatment to be applied in relation to a particular
                item,  then in accordance  with  appropriate  accounting  bases,
                policies,   principles,   practices  and  procedures   generally
                accepted in the United Kingdom.

5       The Purchaser  shall review the Statement  and the  Completion  Accounts
        following delivery of the same by the Vendors'  Representatives pursuant
        to  paragraph  3 and shall,  within 20 Business  Days of such  delivery,
        deliver  to  the  Vendors'   Representatives  a  letter  ("THE  LETTER")
        specifying any disputes or differences  they may have in connection with
        the  Statement  or the  Completion  Accounts,  failing  which (or if the
        Purchaser confirms in writing to the Vendors'

                                       80



        Representatives  that it proposes no  adjustments  to the  Statement  or
        Completion  Accounts) the Statement and the Completion Accounts shall be
        final and binding.

6       The  Vendors  shall  ensure  that  the  Purchaser  and  the  Purchaser's
        Accountants   are  allowed  all   reasonable   access  to  all  relevant
        information,  personnel and records  (including  (provided the Purchaser
        and the  Purchaser's  Accountants  agree  to such  terms  in  connection
        therewith as the Vendors' Accountants may reasonably require) all access
        to the  working  papers  of the  Vendors'  Accountants  relating  to the
        preparation of the profit and loss account and the Closing Balance Sheet
        (which  form  part  of the  Completion  Accounts)  and  relating  to the
        preparation  of the Statement and (to the extent  required) all relevant
        information,  personnel  and records of, or under the control of Penn or
        any  member  of Penn  Group)  for the  purposes  of their  review of the
        Statement.

7       The Vendors jointly on the one part and the Purchaser on the other shall
        each  use  their  reasonable  endeavours  to  resolve  any  disputes  or
        differences  that may be specified in the Letter in connection  with the
        Statement or any matter stated in it within 15 Business  Days  following
        the delivery of the Letter.  If the Vendors and the  Purchaser  agree on
        the  adjustments  to be  made to the  Statement  and/or  the  Completion
        Accounts  they  shall  jointly  incorporate  such  adjustments  into the
        Statement  and  the  Completion  Accounts  and  the  Statement  and  the
        Completion  Accounts shall be final and binding.  Failing  resolution of
        the same within such period (or longer  period as the  Purchaser and the
        Vendors'  Representatives  may agree in  writing)  any such  disputes or
        differences   shall  forthwith  be  referred  to  the  decision  of  the
        Independent Accountant and so that:

        7.1     the Independent  Accountant shall act as an expert and not as an
                arbitrator in connection with the giving of a determination;

        7.2     each determination of the Independent  Accountant shall be final
                and binding on the Parties (save in the case of manifest  error)
                and  shall be  notified  to the  Parties  by means of a  written
                determination of the Independent Accountant; and

        7.3     the  Statement and the  Completion  Accounts as so determined by
                the Independent Accountant shall be final and binding.

8       In the event that an Independent Accountant is so appointed, the Vendors
        jointly  on the one  part  and the  Purchaser  on the  other,  shall  be
        entitled to make such written submissions to the Independent  Accountant
        as they shall  respectively think fit during such period for making such
        submissions as the  Independent  Accountant  shall  determine (but which
        period shall be no longer than 10 Business Days from  appointment of the
        Independent Accountant).

9       Each of the  Vendors  and the  Purchaser  will  promptly  provide to the
        Independent  Accountant all such  information and  documentation  as the
        Independent Accountant may reasonably require.

10      The  Independent  Accountant  shall have the right to such  professional
        assistance  and  advice as the  Independent  Accountant  may  reasonably
        require.

                                       81



11      The  fees  and  expenses  of  the   Independent   Accountant  and  other
        professional  fees  incurred  by the  Independent  Accountant  shall  be
        apportioned between the Vendors on the one part and the Purchaser on the
        other, as the Independent Accountant shall see fit in his determination.

                                       82



                                   SCHEDULE 7

                 Provisions for the protection of the Warrantors
                 -----------------------------------------------

1       INTERPRETATION

1.1     In this schedule 7, unless the context otherwise requires:

        "EXPENSES"   means  all  reasonable   third  party  costs  and  expenses
        (including legal expenses); and

        "WARRANTY  CLAIMS" means all and any claims  against the  Warrantors (or
        any  of  them)  under  any  of the  Warranties,  or the  Representations
        including any claim for breach of contract,  misrepresentation resulting
        from any breach of the Warranties or the  Representations,  save that in
        paragraphs  5.1.2,  6.2,  7.1, 8, 9 and 13  "WARRANTY  CLAIM"  shall not
        include any claim under the Tax  Warranties  (to which  schedule 3 shall
        apply).

2       MAXIMUM LIABILITY

2.1     The  maximum  liability  of the  Warrantors  in respect of all  Warranty
        Claims and claims under the Tax Covenant  shall not exceed the aggregate
        of  the  Purchase  Price,  the  Penn  Group  Indebtedness  and  the  RBS
        Indebtedness  remaining on Completion (in  accordance  with the terms of
        this Agreement) (such aggregate being the "AGGREGATE AMOUNT") multiplied
        by  the  aggregate  of  the  Relevant  Proportions  attributable  to the
        Warrantors.

3       LIABILITY OF EACH WARRANTOR

3.1     The  maximum  liability  of each  Warrantor  in respect of all  Warranty
        Claims and claims under the Tax  Covenant  shall not exceed his Relevant
        Proportion of the Aggregate Amount.

4       SMALL CLAIMS AND THRESHOLD

4.1     Notwithstanding any other provision of this Agreement:

        4.1.1   no  Warranty  Claim or claim  under  the Tax  Covenant  shall be
                brought if the loss  sustained  in respect of which such a claim
                may  properly  be  brought  would  otherwise  be less  than  the
                Individual Threshold; and

        4.1.2   subject to paragraph 4.1.1, no Warranty Claim or claim under the
                Tax  Covenant  shall be  brought  unless the loss  sustained  in
                respect of such claim (when  aggregated  with any other Warranty
                Claims and claims under the Tax Covenant)  exceeds the Aggregate
                Threshold in which case the Purchaser shall be able to claim for
                the full  amount of such  Warranty  Claim or claim under the Tax
                Covenant.

5       TIME LIMITS

5.1     No  Warranty  Claim or claim  under the Tax  Covenant  shall be  brought
        against any of the Warrantors unless:

                                       83



        5.1.1   notice in writing of such claim (specifying in reasonable detail
                the nature of the breach,  or matter  giving rise to such claim,
                and so far as is  practicable  the amount  claimed in respect of
                it) has been given to each  Warrantor  by the  Purchaser  by not
                later than:

                (a)     the date that falls 7 years after the Completion Date in
                        respect of any Warranty  Claim under the Tax  Warranties
                        or any claim under the Tax Covenant; and

                (b)     the date that falls 2 years after the Completion Date in
                        respect of any other Warranty Claim; and

        5.1.2   proceedings  in respect of such  Warranty  Claim shall have been
                both  issued  and  served on any  Warrantor(s)  not later than 6
                months after the relevant date specified in paragraph 5.1.1 (or,
                if later,  the first date upon which the  Purchaser is permitted
                to take steps to recover  against  the  Warrantors  pursuant  to
                paragraph 8.1 in this Schedule 8).

6       GENERAL LIMITATIONS

6.1     The  Warrantors  shall not have any liability in respect of any Warranty
        Claim and  accordingly  no  Warranty  Claim may be brought if and to the
        extent that:

        6.1.1   the  Warranty  Claim  arises  wholly  or  partly  out  of  or in
                connection  with  any  fact,   matter  or  circumstance   fairly
                disclosed in the  Disclosure  Letter or in the schedules to this
                Agreement;

        6.1.2   save in relation to the  Warranties  in  paragraph  27 and 28 of
                Schedule 4, the  Warranty  Claim arises in relation to or out of
                any  Environmental  matters or the  Property  or the  ownership,
                occupation or use of the Property or any other  property at that
                time;

        6.1.3   save in relation to the  Warranties  in paragraph 14 of Schedule
                4,  the  Warranty  Claim  arises  in  relation  to or out of the
                Intellectual Property or the ownership, occupation or use of the
                Intellectual Property or any other intellectual property at that
                time.

6.2     The  Warrantors  shall not have any liability in respect of any Warranty
        Claim and  accordingly  no  Warranty  Claim may be brought if and to the
        extent that one or more of the following provisions apply:

        6.2.1   the  Purchaser  or any  other  member of the  Purchaser's  Group
                successfully recovers an amount against any loss or damage under
                the terms of any  insurance  policy  for the time being in force
                (or could have so  recovered  under the policies of insurance of
                the Company in force at Completion  had they been  maintained in
                force for the benefit of the Company  and/or the  Purchaser)  in
                each case in respect of the matter  giving rise to the  Warranty
                Claim;

        6.2.2   the  Warranty  Claim  arises  wholly  or  partly  out  of  or in
                connection with:

                                       84



                (a)     any matter  provided  for or  contemplated  in each case
                        (specifically  and  expressly)  by  the  terms  of  this
                        Agreement or any other Transaction Document;

                (b)     any voluntary act, omission,  transaction or arrangement
                        of the Purchaser or the Purchaser's Group at any time or
                        of  the  Company  after   Completion  or  any  of  their
                        respective  officers,  agents or successors in title (to
                        the extent only that the  Purchaser  was aware that such
                        change would give rise to a Warranty Claim);

                (c)     any  matter  specifically  provided  for in  the  Latest
                        Accounts or any previous accounts of the Company;

                (d)     any matter  taken into account in the  determination  of
                        the Purchase Price or the  preparation of the Completion
                        Accounts in each case in accordance  with the provisions
                        of this Agreement;

                (e)     any asset acquired by the Company after Completion;

                (f)     the   disposal   by  the  Company  of  any  asset  after
                        Completion;

                (g)     the  passing of a  resolution  for the winding up of the
                        Company after Completion;

                (h)     any change in the nature of the  business of the Company
                        (or in the manner of conducting it) after Completion (to
                        the extent only that the  Purchaser  was aware that such
                        change would give rise to a Warranty Claim);

                (i)     any  statutory  provision  not in  force  at the date of
                        Completion  or any  change  in any  statutory  provision
                        after  the date of  Completion  or any  decision  of the
                        Courts  after the date of this  Completion  altering the
                        accepted interpretation of any statutory provision;

                (j)     any departure from the format, matter, bases, priorities
                        and  principles  used in the  preparation of the audited
                        accounts of the Company after Completion; or

                (k)     any  change  on or after  Completion  of the  accounting
                        reference date of the Company;

        6.2.3   the Warranty Claim arises in connection with any matter or thing
                done or  omitted  prior  to  Completion  by the  Company  at the
                written  request of or with the prior  written  approval  of any
                member  of the  Purchaser's  Group or their  representatives  or
                professional advisers;

        6.2.4   the loss or liability to which such  Warranty  Claim relates has
                been or is made good or otherwise  compensated for at no expense
                to the Company,  the  Purchaser  or any member of the  Purchaser
                Group; or

                                       85



        6.2.6   the loss or liability  suffered or incurred by the  Purchaser to
                which  the  Warranty  Claim  relates  is  contingent,  future or
                unascertainable  and no Warranty Claim may be brought in respect
                of such loss or liability until such time as the Purchaser shall
                have  actually  suffered the loss or incurred  the  liability in
                question.

7       SUBSEQUENT RECOVERY FROM THIRD PARTY

7.1     The  Purchaser  shall  reimburse to each  Warrantor  forthwith an amount
        equal to any sum paid by him in respect of any  Warranty  Claim which is
        subsequently  recovered by or paid to the  Purchaser or any other member
        of the  Purchaser's  Group by any other  person in respect of the matter
        giving  rise to the Claim  (less any  Expenses  incurred  in making such
        recovery and any Taxation thereon (if any)).

7.2     Any amount paid by the Purchaser  pursuant to  paragraphs  4.3 or 7.1 or
        Part 1 of  schedule 3 shall be taken into  account,  with  retrospective
        effect,  in ascertaining  whether the amounts in paragraph 4.1 above are
        exceeded. Any amount previously paid by the Warrantors in respect of any
        Warranty  Claim  which  would  not  otherwise  have  been  payable  as a
        consequence of this paragraph 7.2 shall be repaid immediately.

8       CLAIMS AGAINST THIRD PARTY

8.1     Where the Purchaser or any other member of the Purchaser's  Group may be
        entitled  (whether  by  reason  of  insurance  or  payment  discount  or
        otherwise)  to recover  from some other person any sum in respect of any
        damage or liability the subject of a Warranty Claim, the Purchaser shall
        first take steps or procure that the relevant  member of the Purchaser's
        Group  takes  steps  (including  the  commencement  and  prosecution  of
        proceedings in circumstances  where the Warrantors  reasonably  consider
        that there is a reasonable  chance of recovery) to enforce such recovery
        before  taking  steps (other than notice  pursuant to  paragraph  5.1.1)
        against the Warrantors in respect of such Warranty Claim.

8.2     Whether before or after the  Warrantors  have made payment in respect of
        any  Warranty  Claim,  the  Purchaser  shall,  if  so  required  by  the
        Warrantors,  and,  subject to payment of any Expenses by the Warrantors,
        take, or (as the case may require)  procure that the relevant  member of
        the Purchaser's  Group (and the Purchaser's  officers or the officers of
        the relevant  member of the Purchaser's  Group as applicable)  take, all
        steps  (whether by way of a claim  against its insurers or otherwise) in
        relation to such Warranty Claim as the Warrantors may reasonably require
        to enforce such recovery and shall keep the Warrantors informed to their
        reasonable  satisfaction of the progress of any action taken. Thereafter
        any Warranty  Claim shall be limited (in addition to the  limitations on
        the liability of the  Warrantors  referred to in this schedule 7) to the
        amount by which the loss or damage suffered by the Purchaser as a result
        of such breach shall exceed the amount (if any) so recovered.

                                       86



9       CLAIMS BY THIRD PARTY

9.1     If grounds for any Warranty Claim arise as a result of, or in connection
        with, a claim by, or alleged liability to, a third party (a "THIRD PARTY
        CLAIM"),  the Third  Party  Claim  shall not be  compromised  or settled
        without the prior written  consent of the  Warrantors and the Purchaser,
        such consent not to be  unreasonably  withheld or delayed.  If requested
        promptly  in writing by the  Warrantors  and,  subject to the  Purchaser
        being  indemnified  to its  reasonable  satisfaction  by the  Warrantors
        against all associated Expenses, the Purchaser shall:

        9.1     take,  and shall  procure  that each  member of the  Purchaser's
                Group  (and the  Purchaser's  officers  or the  officers  of the
                relevant member of the Purchaser's  Group, as applicable)  take,
                all such  action as the  Warrantors  may  reasonably  request to
                avoid,  dispute,  resist,  appeal or compromise  the Third Party
                Claim; and

        9.2     make available,  and procure that each member of the Purchaser's
                Group  (and  the  Purchasers  officers  or the  officers  of the
                relevant member of the Purchaser's  Group, as applicable)  shall
                make available, to the Warrantors on request all information and
                reasonable  assistance  which is relevant for that purpose.  The
                Warrantors  shall not use or disclose any such  information  for
                any other purpose.

10      DUTY TO MITIGATE

10.1    Nothing in this Agreement  shall be deemed to relieve the Purchaser from
        its common law duty to mitigate its loss.

11      NO DOUBLE CLAIM

11.1    Neither the Purchaser nor any member of the  Purchaser's  Group shall be
        entitled  to  recover  damages  or any other  amount in  respect  of any
        Warranty  Claim or any claim under the Tax Covenant or otherwise  obtain
        reimbursement  or  restitution  more  than once in  respect  of the same
        matter,  loss or  liability  and for this  purpose  any  payment  by the
        Warrantors  under  the Tax  Covenant  shall be  deemed  to  satisfy  any
        Warranty Claim in respect of the same loss or liability and VICE VERSA.

12      RESCISSION

12.1    No breach of any of the Warranties or the  Representations  or any other
        provision of this Agreement  shall entitle the Purchaser to rescind this
        Agreement after Completion.

12.2    The  provisions  of this  schedule  8 shall  remain in full force and be
        fully  applicable all  circumstances  and, in  particular,  shall not be
        discharged  by any  breach  of this  Agreement  of any  nature or by any
        determination or rescission by the Purchaser of the whole or any part of
        this Agreement.

                                       87



13      RELIEFS

13.1    No  Warranty  Claim  shall  extend  to any  part of any  loss or  damage
        suffered  by the  Purchaser  or the Company to the extent that such part
        shall be used or shall be capable of being used by the  Purchaser or the
        Company  or any  present  or  future  subsidiaries  of either of them to
        offset in whole or in part any past, present or future liability for Tax

14      APPLICATION TO THIRD PARTIES

14.1    Any third party which is entitled  under the terms of this  Agreement to
        claim  against  the  Warrantors  or any of them  shall be subject to the
        provisions of this schedule 7 as if it were the Purchaser.

15      LIABILITY OF TRUSTEES

15.1    The  aggregate  liabilities  of Roger  Spencer Jones and Ann Jones under
        this  Agreement  as trustees of the Roger Jones  Interest in  Possession
        Trust  shall not exceed an amount  equal to the value for the time being
        of the net assets of the Roger Jones  Interest in Possession  Trust held
        by them.

15.2    For the purpose of this  paragraph 15, the net assets of the Roger Jones
        Interest in Possession  Trust shall be the immediately  realisable value
        in  pounds  sterling  of  the  assets  less  any  liability  (actual  or
        contingent) in respect of Tax and professional fees and expenses.

16      NO CLAIMS BY THE COMPANY

16.1    The Purchaser  undertakes to each  Warrantor that neither it nor Celgene
        has actual  knowledge of any fact,  matter or  circumstance  which it is
        actually aware would  constitute a breach of Warranty  and/or would give
        rise to a claim  under  the Tax  Covenant  and in  respect  of which the
        Purchaser intends after the date hereof to make a claim.

17      REDUCTION IN CONSIDERATION

17.1    Any  payment  in respect of any  Warranty  Claim or claim  under the Tax
        Covenant shall take effect as an adjustment to the Purchase Price.

18      FRAUD

18.1    Nothing in this schedule 7 shall  operate to limit or exclude  liability
        of  any  person  for  fraud,   wilful   non-disclosure   or   fraudulent
        misrepresentation.

                                       88



                                   SCHEDULE 8

                    Rights of First Refusal and Last Refusal
                    ----------------------------------------

1       The  provisions  of this  schedule  8 shall only apply in the event of a
        Relevant Transaction and not otherwise and shall following a CR Disposal
        terminate  and be of no further  effect in relation to Craig  Rennie and
        shall following an LI Disposal  terminate and be of no further effect in
        relation  to the  Lead  Investor  and  shall  following  an  Asset  Sale
        terminate and be of no further effect.

2       Subject to the provisions of paragraph 1 of this schedule 8 (which shall
        for the avoidance of doubt prevail), in the event that any person wishes
        to effect a Relevant Transaction then:

        2.1     if the Relevant  Transaction  results from an Unsolicited  Offer
                being received from a Third Party,  the provisions of paragraphs
                6 to 11 inclusive of this schedule 8 shall apply; or

        2.2     if the  Relevant  Transaction  does  not  result  from  such  an
                Unsolicited  Offer,  then the  board of  directors  of Penn (the
                "PENN BOARD") shall serve on the Purchaser a transfer  notice in
                respect of the Offered Shares or Offered Assets, as the case may
                be,  in  accordance  with  paragraph  3 of  this  schedule  8 (a
                "TRANSFER NOTICE").

3       A Transfer  Notice served by the Penn Board in accordance with paragraph
        2.2 above shall:

        3.1     state the number of  Offered  Shares or, in the case of an Asset
                Sale, describe in reasonable detail the Offered Assets;

        3.2     (to the  extent  possible  without  breaching  the  terms of any
                confidentiality  agreement to which Penn, any member of the Penn
                Group or any  shareholder  of Penn is party) state the full name
                and address of the proposed offeree (if any);

        3.3     state the terms  (including as to price,  type of  consideration
                and any  restrictions on the receipt of cash (or its equivalent)
                consideration,  if any) upon which the Offeror  wishes to effect
                the  Relevant  Transaction  or,  if an offer  has been  received
                which, if accepted, would result in a Relevant Transaction,  the
                terms of such offer (the "OFFER TERMS"); and

        3.4     invite  the  Purchaser  to make an offer to  acquire  all of the
                Offered Shares or Offered Assets, as the case may be, upon terms
                that are no less  favourable than the Offer Terms within 14 days
                of the date of the Transfer Notice (the "FIRST REFUSAL PERIOD").

4       If, within the First Refusal Period,  the Purchaser makes no response to
        the Transfer  Notice or confirms  that it does not wish to make an offer
        for the  Offered  Shares or Offered  Assets,  as the case may be, on the
        Offer  Terms at that  time or makes an offer for the  Offered  Shares or
        Offered Assets on terms that are less  favourable  than the Offer Terms,
        then the Penn Board may offer for sale and transfer  the Offered  Shares
        or Offered Assets at any time within the next six

                                       89



        months to a third party  purchaser on any terms  (including as to price)
        provided that these are no less  favourable  than the Offer Terms. If no
        third party offer for the Offered  Shares or Offered  Assets is received
        within the said six month  period,  then the  provisions  of paragraph 2
        shall apply.

5       If, within the First Refusal  Period,  the Purchaser  makes an offer for
        the  Offered  Shares  or  Offered  Assets,  as the case may be, on terms
        which,  taken as a whole  (including as to price,  type of consideration
        and  any  restrictions  on the  receipt  of  cash  (or  its  equivalent)
        consideration),  are no less favourable than the Offer Terms (the "FIRST
        REFUSAL  OFFER"),  then the Offeror shall accept the First Refusal Offer
        and the provisions of paragraph 11 shall apply.

6       If an  Unsolicited  Offer is received by an Offferor  from a third party
        purchaser (the "THIRD PARTY  PURCHASER")  which the Offeror is minded to
        accept,  then the Offeror  shall,  prior to  completion  of the Relevant
        Transaction,  serve on the  Purchaser  a notice in  writing of the Third
        Party Purchaser's offer (the "THIRD PARTY OFFER NOTICE").

7       The Third Party Offer Notice shall:

        7.1     state the number of  Offered  Shares or, in the case of an Asset
                Sale, describe in reasonable detail the Offered Assets;

        7.2     (to the  extent  possible  without  breaching  the  terms of any
                confidentiality  agreement to which Penn, any member of the Penn
                Group or any  shareholder  of Penn is party) state the full name
                and address of the Third Party Purchaser; and

        7.3     invite  the  Purchaser  to make an offer to  acquire  all of the
                Offered Shares or Offered Assets,  as the case may be, within 14
                days  of  the  date  of   receipt  by  the   Purchaser   of  the
                confidentiality undertaking referred to in paragraph 8 below or,
                if the  Purchaser  does not enter  into  such a  confidentiality
                undertaking, within 14 days of the date of the Third Party Offer
                Notice (the "LAST REFUSAL PERIOD").

8       Craig Rennie shall  procure,  or shall procure that Penn shall  procure,
        that a confidentiality undertaking executed by the Third Party Purchaser
        in a form that is in all  material  respects no more  onerous  than that
        agreed  between  the Offeror  and the Third  Party  Purchaser  and which
        expressly  permits the Offeror to disclose  the terms  (including  as to
        price, type of consideration and any restrictions on the receipt of cash
        (or its equivalent) consideration, if any) of the Unsolicited Offer (the
        "THIRD  PARTY OFFER  TERMS") is  delivered  to the  Purchaser as soon as
        practicable  following delivery of the Third Party Offer Notice.  Within
        24 hours of the Purchaser  executing such  confidentiality  undertaking,
        the Offeror  shall notify the  Purchaser of the terms  (including  as to
        price, type of consideration and any restrictions on the receipt of cash
        (or its equivalent) consideration, if any) of the Unsolicited Offer (the
        "THIRD PARTY OFFER TERMS").

9       If, within the Last Refusal  Period,  the Purchaser makes no response to
        the Third Party Offer  Notice or confirms  that it does not wish to make
        an offer for the Offered Shares or Offered  Assets,  as the case may be,
        at that time or makes an offer for the

                                       90



        Offered Shares or Offered Assets on terms that are less  favourable than
        the Third  Party  Offer  Terms,  then the Offeror may offer for sale and
        transfer  the  Offered  Shares or Offered  Assets at any time within the
        next six months to the Third Party  Purchaser  on terms  including as to
        price that in all  material  respects  are no less  favourable  than the
        Third Party Offer Terms.

10      If, within the Last Refusal Period, the Purchaser makes an offer for the
        Offered  Shares or Offered  Assets,  as the case may be, on terms which,
        taken as a whole (including as to price,  type of consideration  and any
        restrictions on the receipt of cash (or its equivalent)  consideration),
        are no less  favourable  than the Third  Party  Offer  Terms  (the "LAST
        REFUSAL  OFFER"),  then the Offeror  shall accept the Last Refusal Offer
        and the provisions of paragraph 11 shall apply.

11      If the Offeror  notifies the Purchaser  that it accepts either the First
        Refusal  Offer or the Last Refusal  Offer (as the case may be), then the
        Offeror  shall  be bound  to sell  and the  Purchaser  shall be bound to
        purchase all of the Offered  Shares or Offered  Assets,  as the case may
        be,  within  14 days of the date of the  notice of  acceptance  (or such
        longer period as the Offeror and the Purchaser  shall agree in writing).
        Between  the date of the notice of  acceptance  and the expiry of the 14
        day  period,  the  Offeror  shall  permit the  Purchase  to  undertake a
        reasonable  due  diligence  exercise and the  Purchaser  and the Offeror
        shall  negotiate  in good  faith to agree the  terms of the  transaction
        including,   without  limitation,  the  extent  of  the  warranties  and
        indemnities to be given by the Offeror;  provided always that: (a) in no
        circumstances   shall  either  the  Lead   Investor  of  its   Permitted
        Transferees  be required to give any  warranties or  indemnities  (other
        than  warranties in relation to title to shares and capacity) and (b) in
        no circumstances shall the Offeror be required to give any warranties or
        accept any  liability  to the extent that the same is greater  than that
        required  by  the  Third  Party   Purchaser.   The  Purchaser  shall  be
        responsible  for  payment  of any stamp  duties  on any sale of  Offered
        Shares  to it  pursuant  to  this  schedule  8.  If  the  terms  of  the
        transaction  are not agreed within such 14 day period  referred to above
        (or such longer period as the Offeror and the  Purchaser  shall agree in
        writing),  then the  provisions  of clause 4 or 9 shall  apply as if the
        Purchaser  had made no  response to the  Transfer  Notice or Third Party
        Offer Notice (whichever is applicable).

12      If the Articles  are amended or replaced and at the relevant  time it is
        possible  under the  terms of this  schedule  that one or more  Relevant
        Transactions  could take  place,  the  Vendors  shall  procure  that the
        amended or  replacement  Articles  include  provisions  on the same,  or
        substantially  the same,  terms as those set out at  Article  6.6 of the
        Articles.

13      The Vendors  shall use their  reasonable  endeavours  to ensure that any
        confidentiality  agreement  entered into by Penn, any member of the Penn
        Group or any  shareholder  of Penn does not  operate to prevent the full
        name and address of any Third Party  Purchaser  being  disclosed  to the
        Purchaser in accordance with paragraphs 3.2 and 7.2.

14      In this Schedule, unless the context otherwise requires:

                                       91



        "ARTICLES" means the articles of association of Penn at the date hereof,
        a copy of which is annexed hereto;

        "ASSET SALE" means any transaction which results in all or substantially
        all of the  assets,  business  and  undertaking  of Penn  Pharmaceutical
        Services Limited being transferred to a Third Party;

        "CONTROL" means the power to exercise a majority of the voting rights at
        general  meeting of Penn,  whether  through the  ownership  of the legal
        and/or  beneficial  interest in a majority  of the issued  shares in the
        capital of Penn or by contract or otherwise;

        "CR  DISPOSAL"  means any  transaction  pursuant to which  Craig  Rennie
        transfers to any person other than a Permitted  Transferee  the legal or
        beneficial interest in some or all of his shares in Penn and as a result
        of which Craig  Rennie  ceases to control  Penn or, if Craig Rennie does
        not control Penn immediately prior to such transaction,  following which
        he does not obtain control of Penn;

        "CR OFFERED  SHARES" means either (a) those shares in Penn held by Craig
        Rennie or his Permitted Transferees that are the subject of the Relevant
        Transaction  or (b) if those  shares  would not,  when  acquired  by the
        Purchaser,  allow the  Purchaser  to  exercise a majority  of the voting
        rights in  general  meeting  of Penn,  all of the shares in Penn held by
        Craig Rennie or his Permitted  Transferees  or, if less,  such number of
        shares in Penn  held by Craig  Rennie or his  Permitted  Transferees  as
        would allow the Purchaser to exercise such a majority;

        "LI DISPOSAL" means any  transaction  which results in the Lead Investor
        transferring  to any  person or persons  other than Craig  Rennie or its
        Permitted Transferee the legal and/or beneficial interest in some or all
        of its shares in Penn where any such person or persons would acquire the
        same or similar  rights and  privileges in relation to Penn as were held
        by the Lead Investor at the date of Completion;

        "OFFERED  ASSETS"  means  the  assets,  business  or  undertaking  to be
        transferred pursuant to an Asset Sale;

        "OFFERED  SHARES"  means  (a)  where the  Relevant  Transaction  is a CR
        Disposal,  the CR Offered Shares, (b) where the Relevant  Transaction is
        an LI Disposal,  those  shares in Penn held by the Lead  Investor or its
        Permitted  Transferees that are the subject of the Relevant Transaction,
        and (c) where the Relevant  Transaction  is both a CR Disposal and an LI
        Disposal,  the CR Offered  Shares  and those  shares in Penn held by the
        Lead Investor or its Permitted  Transferees  that are the subject of the
        Relevant Transaction;

        "OFFEROR"  means (a) where the  Relevant  Transaction  is a CR Disposal,
        Craig  Rennie or his  Permitted  Transferees,  (b)  where  the  Relevant
        Transaction  is an LI  Disposal,  the  Lead  Investor  or its  Permitted
        Transferees,  and (c) where the Relevant  Transaction  is an Asset Sale,
        Penn or (d) where the Relevant  Transaction is both a CR Disposal and an
        LI  Disposal,  Craig  Rennie and the Lead  Investor or their  respective
        Permitted Transferees;

                                       92



        "PENN" includes the ultimate holding company of Penn;

        "PERMITTED  TRANSFEREES"  means any person to whom a permitted  transfer
        could be made in accordance with Article 6.2 of the Articles;

        "RELEVANT  TRANSACTION" means a CR Disposal,  an LI Disposal or an Asset
        Sale;

        "THIRD PARTY" means any person that is not a Permitted Transferee; and

        "UNSOLICITED  OFFER"  means an offer  (whether  legally  binding or not)
        which, if accepted, would result in a Relevant Transaction and which has
        not been solicited by any  shareholder or officer of Penn or any adviser
        to Penn or which does not  result in any way from any kind of  marketing
        of, or offer to sell,  any of the  shares,  assets or control  rights of
        Penn in respect of which the offer is received.

                                       93



                                   SCHEDULE 9

                                Celgene Guarantee
                                -----------------


1       In  consideration  of the Vendors  entering into this Agreement with the
        Purchaser, Celgene hereby irrevocably and unconditionally:

        1.1     undertakes and guarantees the due and punctual  performance  and
                observance by the Purchaser of each  obligation of the Purchaser
                under this Agreement; and

        1.2     undertakes  to the Vendor on demand to pay to the Vendor any sum
                which the  Purchaser  is at any time liable to pay to the Vendor
                under or arising out of this  Agreement and which is not paid at
                the time of the demand.

2       Celgene's  obligations under paragraph 1 are primary obligations and not
        those of a mere  surety.  If an  obligation  of the  Purchaser  is void,
        voidable or  unenforceable  for any reason,  Celgene's  obligation under
        this Schedule are unaffected  and Celgene shall perform the  Purchaser's
        obligations as if it were primarily liable for the performance.

3       The  guarantee  contained in paragraph 1 is a continuing  guarantee  and
        shall remain in force until all the  obligations of the Purchaser  under
        this  Agreement  have been fully  performed  and all sums payable by the
        Purchaser have been fully paid.

4       The  obligations  of  Celgene  shall  not be  satisfied,  discharged  or
        affected  by any act,  omission,  matter  or thing  which,  but for this
        provision,  might  operate to diminish or  discharge  the  liability  of
        Celgene  from its  obligations  or provide a defence to it or  otherwise
        affect its obligations whether or not known to Celgene including:

        4.1     any time or other indulgence,  waiver, release or consent at any
                time given to the  Purchaser  or any other person in relation to
                the terms of this Agreement;

        4.2     any  compromise or release of or abstention  from  perfecting or
                enforcing any right or remedy against the Purchaser or any other
                person;

        4.3     any   legal   limitation,   disability,   incapacity   or  other
                circumstance  relating to the  Purchaser  or any other person or
                any amendment to or variation of the terms of this  Agreement or
                any other  document  referred to in this  Agreement  whether the
                same is made with or without the assent or knowledge of Celgene;

        4.4     any irregularity, illegality,  unenforceability or invalidity of
                any  obligations  of the Purchaser  under this  Agreement or the
                winding-up, the dissolution, amalgamation, reconstruction, other
                change in the constitution or control of or the compounding with
                or accepting composition from or insolvency of the Purchaser;

                                       94



        4.5     any  intermediate  payment  or  settlement  of  account  by  the
                Purchaser; and

        4.6     any variation,  renewal,  termination or discharge of a party to
                other  securities  or  guarantees  held  by the  Vendors  or any
                realisation of all or any of those securities or guarantees.

5       The  guarantee  contained  in paragraph 1 may be enforced by the Vendors
        without the Vendors  first taking any steps or  proceedings  against the
        Purchaser.

6       All  payments  to be made by  Celgene  shall  be made in  full,  without
        set-off or counterclaim and without any deduction  whatsoever  except to
        the extent required by law.

7       So long as the  Purchaser  is under an actual or  contingent  obligation
        under this Agreement, Celgene shall not exercise any right it may at any
        time  have  by  reason  of  the  performance  of its  obligations  under
        paragraphs 1, 2 and 3, to take the benefit  (wholly or partly and by way
        of  subrogation  or otherwise)  of any of the Vendors  rights under this
        Agreement or of any other  security  taken by the Vendors in  connection
        with this Agreement.

                                       95



                                  SCHEDULE 10

                        Trustees Covenants and Warranties
                        ---------------------------------

1       COVENANTS

        As trustees of the Roger Jones  Interest in  Possession  Trust,  each of
        Roger  Spencer  Jones and Ann Jones (the  "TRUSTEES")  covenants  to and
        undertakes  with the Purchaser  that in relation to Trust and during the
        period  commencing on the date of  Completion  and ending on the seventh
        anniversary of the date of Completion:

        (a)     he will neither  resign nor retire as a Trustee of the Trust nor
                exercise  any right or power to appoint  any  additional  or new
                trustee of the Trust (the "NEW TRUSTEE")  without  notifying the
                Purchaser accordingly and without procuring that any New Trustee
                shall as a condition  precedent to such appointment  execute and
                deliver to the Purchaser a deed of adherence in the agreed terms
                and  on the  entering  into,  completion,  and  delivery  to the
                Purchaser  of such a deed by the New  Trustee  the  retiring  or
                resigning  Trustee shall (except in relation to any claim notice
                of which has previously been given) thereupon be discharged from
                all or any liability under this Agreement;

        (b)     he will not  distribute  any Trust capital from the sole control
                of him and his  fellow  trustees  without  first  notifying  the
                Purchaser and procuring  that any  beneficiary  or transferee of
                such a  distribution  shall as a condition  precedent  to such a
                distribution  execute  and  deliver to the  Purchaser  a deed to
                indemnify the Purchaser (in a form  reasonably  satisfactory  to
                the  Purchaser)  from and against all  liabilities in respect of
                which the Trustees are liable to the  Purchaser  under the terms
                of this  Agreement to a maximum amount of the amount or value of
                the assets  comprised  in the  distribution  at the date thereof
                (the "DISTRIBUTION VALUE");

        (c)     he will not without the written  consent of the  Purchaser  make
                any distribution,  loan or transfer out of the assets subject to
                the Trust at any time after notice  shall have been  received by
                him of a claim or claims  (together  with a bona  fide  estimate
                thereof) by the  Purchaser  against him under the  provisions of
                this  Agreement,  without  first  setting aside and retaining as
                part of the  assets of the Trust an amount of cash  equal to the
                amount of such claim or bona fide estimate.

        (d)     he will not without the written  consent of the Purchaser,  such
                consent not to be unreasonably  withheld or delayed,  change the
                governing law of the Trust from English law.

2       LEGAL OWNERS OF SHARES

        Each of the  Trustees in relation  to the Trust (with the  intention  of
        binding not only  themselves  but also their  respective  successors and
        assignees) hereby

                                       96



        severally  warrants to the Purchaser that they or their nominees are the
        legal  owners of the Shares shown in Schedule 5, Part 1 as being held by
        them and those Shares will at  Completion be  transferred  free from all
        pledges, liens, charges, equities, encumbrances rights of pre-emption or
        interests in favour of any other person, body or authority and they will
        have power to  transfer  the full legal and  beneficial  interest in the
        Shares to the Purchaser.

3       POWER AND AUTHORITY

        Each of the Trustees in relation to the Trust hereby severally  warrants
        to the Purchaser that he has the requisite  power and authority to enter
        into  this  deed  and  to  give  and to  undertake  the  warranties  and
        obligations  given and  undertakes  by him in his capacity as a Trustee,
        Vendor and Warrantor under this deed.

                                       97



                                  SCHEDULE 11

          Relevant documents for paragraph 1.1 of part 1 of Schedule 4
          ------------------------------------------------------------

References in column 1 are to document numbers in the disclosure bundle.


- --------------------------------------------------------------------------------
KEY AGREEMENTS

- ---------- ---------------------------------------------------------------------
4.3         Distribution  and  licence  agreement  dated 7 March  2001  between
            Pharmion GMBH and Penn Pharmaceuticals Limited

- ---------- ---------------------------------------------------------------------
4.4         Amended and restated  distribution  and licence  agreement  dated 7
            March 2001 between  Pharmion GmbH and Inhoco 2388 Limited (now Penn
            T Limited)

- ---------- ---------------------------------------------------------------------
4.5         Supplementary  agreement to amended and restated  distribution  and
            licence agreement dated 18 June 2003 between Pharmion GmbH and Penn
            T Limited

- ---------- ---------------------------------------------------------------------
4.6         Amendment number 1 to amended and restated distribution and licence
            agreement  dated 4 March  2003  between  Pharmion  GmbH  and Penn T
            Limited

- ---------- ---------------------------------------------------------------------
4.7         Distribution agreement dated 1 July 2002 between Penn T Limited and
            RHC USA Corporation

- ---------- ---------------------------------------------------------------------
4.8         Amended  distribution  agreement  dated 10 May 2004  between Penn T
            Limited and RHC USA Corporation

- ---------- ---------------------------------------------------------------------
4.9         Distribution agreement,  undated, between Penn T Limited and BL & H
            International Corp

- ---------- ---------------------------------------------------------------------
4.13        Manufacturing   agreement   dated   December   1995   between  Penn
            Pharmaceuticals Limited and Celgene Corporation

- ---------- ---------------------------------------------------------------------
4.14        Letter  agreement  dated 14 August 2000 amending the  manufacturing
            agreement  entered  into  in  December  1995  by and  between  Penn
            Pharmaceuticals Limited and Celgene Corporation

- ---------- ---------------------------------------------------------------------
7.1          Letter dated 16 June 2003

- ---------- ---------------------------------------------------------------------
SAURAMIDE

- ---------- ---------------------------------------------------------------------
2.16        Details  of sales of  Sauramide  between  1 July 2004 and 31 August
            2004

- ---------- ---------------------------------------------------------------------
2.17        List of current  Sauramide  customers and  Sauramide  sales between
            01/07/03 and 30/06/04

- ---------- ---------------------------------------------------------------------


                                       98



- ---------- ---------------------------------------------------------------------
2.24        Sales Process for Penn Pharmaceutical Services Limited

- ---------- ---------------------------------------------------------------------
15.1        Sauramide: Customer details report

- ---------- ---------------------------------------------------------------------
15.2        E-mail dated 2 September  2004 - relating to timelines for approval
            of Thalidomide

- ---------- ---------------------------------------------------------------------
INSURANCE

- ---------- ---------------------------------------------------------------------
4.1         Insurance register for Penn Pharmaceuticals Limited date of issue 9
            January 2004

- ---------- ---------------------------------------------------------------------
4.18        Table of Syndicates for Insurance Policy 12 December 2003

- ---------- ---------------------------------------------------------------------
4.19        Lloyd's Insurance Policy 12 November 2003

- ---------- ---------------------------------------------------------------------
LICENSES

- ---------- ---------------------------------------------------------------------
8.1         Manufacturer's  special  licence  dated 19 December 2001 granted to
            Penn Pharmaceutical Services Limited

- ---------- ---------------------------------------------------------------------
8.2         Manufacturers  licence  dated  19  December  2001  granted  to Penn
            Pharmaceutical Services Limited

- ---------- ---------------------------------------------------------------------
8.3         Wholesale dealers (importation from non-EC countries) licence dated
            15 July 1999 granted to Penn Pharmaceutical Services Limited

- ---------- ---------------------------------------------------------------------
8.4         Wholesale  dealers  licence  dated 29 October  1999 granted to Penn
            Pharmaceutical Services Limited

- ---------- ---------------------------------------------------------------------
8.5         Manufacturers  authorisation - investigational  medicinal  products
            dated 1 May 2004 granted to Penn Pharmaceutical Services Limited

- ---------- ---------------------------------------------------------------------

                                       99



                                   Annexure 1
                                   ----------

                           Celgene Pharmion Agreement
                           --------------------------




































                                      100



                                   Annexure 2
                                   ----------

                      Penn Celgene Manufacturing Agreement
                      ------------------------------------




































                                      101



                                   Annexure 3
                                   ----------

                                Option Agreement
                                ----------------




































                                      102



                                   Annexure 4
                                   ----------

                         Articles of Association of Penn
                         -------------------------------




































                                      103



EXECUTED and delivered as a DEED        )
by KEN CALDICOTT                        )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation



EXECUTED and delivered as a DEED        )
by STEVE EVANS                          )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation



EXECUTED and delivered as a DEED        )
by Christopher Higgins                  )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation

                                      104



EXECUTED and delivered as a DEED        )
by JEREMY HYDE                          )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation



EXECUTED and delivered as a DEED        )
by ROGER SPENCER JONES and              )
ANN JONES                               )    ...................................
as trustees of The Roger Jones Interest )
in Possession Trust in the              )
presence of:                            )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation



EXECUTED and delivered as a DEED        )
by CRAIG RENNIE                         )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation

                                      105



EXECUTED and delivered as a DEED        )
by PETER SKELLON                        )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation



EXECUTED and delivered as a DEED        )
by GLYN TONGE                           )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation



EXECUTED and delivered as a DEED        )
by BRYN WILLIAMS                        )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation

                                      106



EXECUTED and delivered as a DEED        )
by KEREN WINMILL                        )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation



EXECUTED and delivered as a DEED        )
by DAVID HENDERSON                      )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation


EXECUTED and delivered as a DEED        )
by PAUL THOMAS                          )
in the presence of:                     )    ...................................

.........................................
Witness signature

.........................................
Witness name (Block Capitals)

.........................................
Witness occupation

                                      107



EXECUTED and delivered as a DEED        )
by barrington house nominees            )
LIMITED CUSTOMERS B  acting by:         )    ...................................
                                             Director


                                             ...................................
                                             Director/Secretary





EXECUTED and delivered as a DEED        )
by CELGENE CORPORATION                  )
acting by:                              )    ...................................
                                             Director


                                             ...................................
                                             Director/Secretary



EXECUTED and delivered as a DEED        )
by celgene uk manufacturing             )
limited acting by:                      )    ...................................
                                             Director


                                             ...................................
                                             Director/Secretary

                                      108