EXHIBIT 99.1

[ENZO LOGO OMITTED]Enzo                                  news
                                                         release
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                                                         ENZO BIOCHEM, INC.
                                                             527 MADISON AVENUE
                                                         NEW YORK, NY 10022

FOR IMMEDIATE RELEASE

                  ENZO BIOCHEM APPOINTS MELVIN F. LAZAR AS LEAD
                              INDEPENDENT DIRECTOR
                                  ------------

FARMINGDALE,  NY,  November  4,  2005  - Enzo  Biochem,  Inc.  (NYSE:ENZ)  today
announced  that its  Board  of  Directors  has  established  a lead  independent
director  position and has appointed  Melvin F. Lazar to serve in that capacity.
Mr. Lazar has been a member of Enzo's  Board of Directors  since August 1, 2002,
and  serves  on the  Audit  Committee,  the  Compensation  Committee  and is the
Chairman of its Nominating/Governance Committee of the Board of Directors.

Elazar  Rabbani,  Enzo's  Chairman  of the  Board and  Chief  Executive  Officer
commented,  "The  creation  of the  role  of  lead  independent  director  is an
important  step  to  further  enhance  our  board   independence  and  corporate
governance.  We are fortunate to be able to call on the talent and experience of
Melvin Lazar in this newly created role."

The duties and  responsibilities of the lead independent  director are set forth
in the lead independent director charter adopted by the Board today. Among other
things,  the lead  independent  director will  coordinate  the activities of the
independent  directors,  serve as a liaison  between the  Chairman of the Board,
Enzo's senior management and Enzo's  independent  directors,  and preside at the
executive  sessions  of  Enzo's  independent  directors.  Independent  directors
represent five of the eight Board members. The lead independent director charter
is available on our website at www.enzo.com.

ABOUT ENZO

         Enzo Biochem is engaged in the research, development and manufacture of
innovative   health  care  products  based  on  molecular  biology  and  genetic
engineering  techniques,  and in  providing  diagnostic  services to the medical
community.  The Company's  proprietary  labeling and detection products for gene
sequencing and genetic analysis are sold to the life sciences market  throughout
the world. The Company's  therapeutic  division is in various stages of clinical
evaluation  of its  proprietary  gene  medicine  for  HIV-1  infection  and  its
proprietary  immune  regulation  medicines  for  hepatitis  B  and  hepatitis  C
infection and for Crohn's Disease.  Pre-clinical  research is being conducted on
several  candidate  compounds  aimed at producing  new mineral and organic bone,
including  technology that could provide therapy for osteoporosis and fractures,
among other applications.  The Company also holds a patent covering a method and
materials for  correcting  point  mutations or small  insertions or deletions of
genetic   material  that  would  allow  for  editing  and   correcting   certain
abnormalities in genes. The Company owns or licenses over 230 patents worldwide.
For more information visit our website WWW.ENZO.COM.

         EXCEPT FOR HISTORICAL  INFORMATION,  THE MATTERS DISCUSSED IN THIS NEWS
RELEASE MAY BE  CONSIDERED  "FORWARD-LOOKING"  STATEMENTS  WITHIN THE MEANING OF
SECTION  27A OF THE  SECURITIES  ACT OF 1933,  AS AMENDED AND SECTION 21E OF THE
SECURITIES   EXCHANGE  ACT  OF  1934,  AS  AMENDED.   SUCH  STATEMENTS INCLUDE



DECLARATIONS REGARDING THE INTENT, BELIEF OR CURRENT EXPECTATIONS OF THE COMPANY
AND ITS  MANAGEMENT.  INVESTORS  ARE  CAUTIONED  THAT ANY  SUCH  FORWARD-LOOKING
STATEMENTS  ARE NOT  GUARANTEES  OF FUTURE  PERFORMANCE  AND INVOLVE A NUMBER OF
RISKS AND UNCERTAINTIES THAT COULD MATERIALLY AFFECT ACTUAL RESULTS. THE COMPANY
DISCLAIMS ANY OBLIGATIONS TO UPDATE ANY FORWARD-LOOKING STATEMENT AS A RESULT OF
DEVELOPMENTS OCCURRING AFTER THE DATE OF THIS PRESS RELEASE.

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CONTACT:
     For: Enzo Biochem, Inc.
     Steve Anreder, 212-532-3232      Or   Ed Lewis, CEOcast, Inc., 212-732-4300