Exhibit 32.1

                        CERTIFICATION OF PERIODIC REPORT

I, John G. Baust, Chief Executive Officer and Chief Financial Officer of Biolife
Solutions,  Inc.  (the  "Company"),  certify,  pursuant  to  Section  906 of the
Sarbanes-Oxley Act of 2002, 18 U.S.C. Section 1350, that:

       1.  the Quarterly  Report on Form 10-QSB of the Company for the quarterly
           period ended March 31, 2005 (the  "Report")  fully  complies with the
           requirements of Section 13(a) or 15(d) of the Securities Exchange Act
           of 1934 (15 U.S.C. 78m or 78o(d)); and

       2.  the  information  contained  in the Report  fairly  presents,  in all
           material respects,  the financial condition and results of operations
           of the Company.


Dated:   November 14, 2005

                                                    /s/ JOHN G. BAUST
                                                  ---------------------------
                                                  John G. Baust, PhD
                                                  Chief Executive Officer and
                                                  Chief Financial Officer



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