Exhibit 32.1

                        CERTIFICATION OF PERIODIC REPORT

I, John G. Baust, Chief Executive Officer and Chief Financial Officer of Biolife
Solutions, Inc. (the "Company"), certify, pursuant to Section 906 of the
Sarbanes-Oxley Act of 2002, 18 U.S.C. Section 1350, that:

     1.   the Quarterly Report on Form 10-QSB of the Company for the quarterly
          period ended June 30, 2005 (the "Report") fully complies with the
          requirements of Section 13(a) or 15(d) of the Securities Exchange Act
          of 1934 (15 U.S.C. 78m or 78o(d)); and

     2.   the information contained in the Report fairly presents, in all
          material respects, the financial condition and results of operations
          of the Company.

Dated: November 14, 2005

                                           /s/ John G. Baust
                                           -----------------------------
                                           John G. Baust, PhD
                                           Chief Executive Officer and
                                           Chief Financial Officer







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