Exhibit 10.1

                             SUBSCRIPTION AGREEMENT



Enzo Biochem, Inc.
527 Madison Ave.
New York, NY 10022

Gentlemen:

The  undersigned  (the  "INVESTOR")  hereby  confirms its agreement  with you as
follows:

       1.     This Subscription  Agreement (this  "AGREEMENT") is made as of the
date set forth below between Enzo  Biochem,  Inc., a New York  corporation  (the
"COMPANY"), and the Investor.

       2.     The  Company  has  authorized  the sale and  issuance  to  certain
investors of up to an aggregate of 3,285,715 shares (the "SHARES") of its Common
Stock, par value $0.01 per share (the "COMMON STOCK"),  subject to adjustment by
the Company's Board of Directors,  or a committee thereof,  for a purchase price
of $14.00 per share (the "PURCHASE PRICE").

       3.     The  offering  and sale of the Shares (the  "OFFERING")  are being
made pursuant to (1) an effective  Registration Statement on Form S-3 (including
the Prospectus  contained  therein (the "BASE  PROSPECTUS"),  the  "REGISTRATION
STATEMENT")  filed by the Company with the  Securities  and Exchange  Commission
(the "COMMISSION"),  (2) if applicable,  certain "free writing prospectuses" (as
that term is defined in Rule 405 under the  Securities Act of 1933, as amended),
that have or will be filed with the  Commission and delivered to the Investor on
or prior to the date hereof and (3) a  Prospectus  Supplement  (the  "PROSPECTUS
SUPPLEMENT" and together with the Base Prospectus,  the "PROSPECTUS") containing
certain supplemental  information regarding the Shares and terms of the Offering
that will be filed with the  Commission  and  delivered to the Investor (or made
available to the Investor by the filing by the Company of an electronic  version
thereof with the Commission).

       4.     The Company and the Investor agree that the Investor will purchase
from the Company and the Company  will issue and sell to the Investor the Shares
of Common  Stock set forth  below  for the  aggregate  purchase  price set forth
below.  The Shares shall be purchased  pursuant to the Terms and  Conditions for
Purchase of Shares  attached hereto as ANNEX I and  incorporated  herein by this
reference  as if fully set forth  herein.  The  Investor  acknowledges  that the
Offering  is not being  underwritten  by the  placement  agent  (the  "PLACEMENT
AGENT") named in the Prospectus Supplement and that there is no minimum offering
amount.

       5.     The manner of settlement  of the Shares  purchased by the Investor
shall be determined by such Investor as follows (CHECK ONE):

[____] A. Delivery by  electronic  book-entry  at The  Depository  Trust Company
          ("DTC"),  registered in the  Investor's  name and address as set forth
          below,  and released by American Stock  Transfer & Trust Company,  the
          Company's  transfer agent (the "TRANSFER  AGENT"),  to the



          Investor at the Closing.  NO LATER THAN ONE (1) BUSINESS DAY AFTER THE
          EXECUTION OF THIS  AGREEMENT  BY THE  INVESTOR  AND THE  COMPANY,  THE
          INVESTOR SHALL:

          (I)  DIRECT THE  BROKER-DEALER  AT WHICH THE ACCOUNT OR ACCOUNTS TO BE
               CREDITED   WITH  THE   SHARES   ARE   MAINTAINED   TO  SET  UP  A
               DEPOSIT/WITHDRAWAL AT CUSTODIAN ("DWAC") INSTRUCTING THE TRANSFER
               AGENT TO CREDIT SUCH ACCOUNT OR ACCOUNTS WITH THE SHARES, AND

          (II) REMIT BY WIRE TRANSFER THE AMOUNT OF FUNDS EQUAL TO THE AGGREGATE
               PURCHASE PRICE FOR THE SHARES BEING  PURCHASED BY THE INVESTOR TO
               THE FOLLOWING ACCOUNT:

                   THE CITIBANK PRIVATE BANK
                   666 Fifth Avenue, 5th Floor
                   New York, NY 10103
                   ABA # 021-000-089
                   Account Name: Thelen Reid Brown Raysman & Steiner LLP, escrow
                   agent for the account of Enzo Biochem, Inc.
                   Account Number: 9970183451


       - OR -

[____] B. Delivery versus payment  ("DVP") through DTC (i.e.,  the Company shall
          deliver Shares  registered in the  Investor's  name and address as set
          forth below and released by the Transfer Agent to the Investor through
          DTC at the  Closing  directly  to the  account(s)  at  Lazard  Capital
          Markets LLC ("LCM")  identified  by the  Investor  and  simultaneously
          therewith  payment  shall  be  made  by LCM by  wire  transfer  to the
          Company).  NO LATER THAN ONE (1) BUSINESS  DAY AFTER THE  EXECUTION OF
          THIS AGREEMENT BY THE INVESTOR AND THE COMPANY, THE INVESTOR SHALL:

          (I)  NOTIFY LCM OF THE ACCOUNT OR ACCOUNTS AT LCM TO BE CREDITED  WITH
               THE SHARES BEING PURCHASED BY SUCH INVESTOR, AND

          (II) CONFIRM  THAT THE ACCOUNT OR ACCOUNTS AT LCM TO BE CREDITED  WITH
               THE SHARES BEING PURCHASED BY THE INVESTOR HAVE A MINIMUM BALANCE
               EQUAL  TO THE  AGGREGATE  PURCHASE  PRICE  FOR THE  SHARES  BEING
               PURCHASED BY THE INVESTOR.

IT IS THE INVESTOR'S  RESPONSIBILITY  TO (A) MAKE THE NECESSARY WIRE TRANSFER OR
CONFIRM  THE PROPER  ACCOUNT  BALANCE IN A TIMELY  MANNER  AND (B)  ARRANGE  FOR
SETTLEMENT  BY WAY OF DWAC OR DVP IN A TIMELY  MANNER.  IF THE INVESTOR DOES NOT
DELIVER  THE  AGGREGATE  PURCHASE  PRICE FOR THE SHARES OR DOES NOT MAKE  PROPER
ARRANGEMENTS FOR SETTLEMENT IN A TIMELY MANNER,  THE SHARES MAY NOT BE DELIVERED
AT

                                     - 2 -


CLOSING  TO THE  INVESTOR  OR THE  INVESTOR  MAY BE  EXCLUDED  FROM THE  CLOSING
ALTOGETHER.

6.     The Investor  represents that,  except as set forth below, (a) it has had
no position,  office or other material  relationship within the past three years
with the Company or persons known to it to be affiliates of the Company,  (b) it
is not a NASD member or an Associated  Person (as such term is defined under the
NASD Membership and Registration Rules Section 1011) as of the Closing,  and (c)
neither the  Investor  nor any group of  Investors  (as  identified  in a public
filing made with the  Commission)  of which the Investor is a part in connection
with the Offering of the Shares, acquired, or obtained the right to acquire, 20%
or more of the Common Stock (or securities  convertible  into or exercisable for
Common  Stock) or the voting power of the Company on a  post-transaction  basis.
Exceptions:

- --------------------------------------------------------------------------------
        (If no exceptions, write "none." If left blank, response will be
                             deemed to be "none.")

7.     The  Investor  represents  that it has received  (or  otherwise  had made
available to it by the filing by the Company of an  electronic  version  thereof
with the Commission)  the Base  Prospectus,  dated November 3, 2006,  which is a
part of the Company's  Registration  Statement,  the documents  incorporated  by
reference therein and any free writing prospectus (collectively, the "DISCLOSURE
PACKAGE"),  prior to or in connection  with the receipt of this  Agreement.  The
Investor  acknowledges  that,  prior to the  delivery of this  Agreement  to the
Company, the Investor will receive certain additional  information regarding the
Offering,  including  pricing  information  (the "OFFERING  INFORMATION").  Such
information  may be provided to the  Investor by any means  permitted  under the
Act,  including the Prospectus  Supplement,  a free writing  prospectus and oral
communications.

8.     No offer by the  Investor to buy Shares  will be accepted  and no part of
the  Purchase  Price will be  delivered  to the Company  until the  Investor has
received the  Offering  Information  and the Company has accepted  such offer by
countersigning a copy of this Agreement,  and any such offer may be withdrawn or
revoked,  without obligation or commitment of any kind, at any time prior to the
Company (or a Placement  Agent on behalf of the  Company)  sending  (orally,  in
writing or by  electronic  mail)  notice of its  acceptance  of such  offer.  An
indication  of interest  will involve no  obligation  or  commitment of any kind
until  the  Investor  has  been  delivered  the  Offering  Information  and this
Agreement is accepted and countersigned by or on behalf of the Company.

                                     - 3 -


Number of Shares:_________________________________

Purchase Price Per Share: $_______________________

Aggregate Purchase Price: $_______________________


         Please  confirm that the foregoing  correctly  sets forth the agreement
between us by signing in the space provided below for that purpose.



                                         Dated as of:  December __, 2006



                                         _______________________________________
                                         INVESTOR

                                         By:____________________________________
                                         Print Name:____________________________
                                         Title:_________________________________
                                         Address:_______________________________
                                         _______________________________________


Agreed and Accepted
this ___ day of December, 2006:


ENZO BIOCHEM, INC.


By:_________________________________
Name:
Title:

                                     - 4 -


                                     ANNEX I

                   TERMS AND CONDITIONS FOR PURCHASE OF SHARES

         1.       AUTHORIZATION AND SALE OF THE SHARES. Subject to the terms and
conditions of this Agreement, the Company has authorized the sale of the Shares.

         2.       AGREEMENT TO SELL AND PURCHASE THE SHARES; PLACEMENT AGENT.

                  2.1      At the  Closing  (as  defined  in SECTION  3.1),  the
Company will sell to the  Investor,  and the  Investor  will  purchase  from the
Company,  upon the terms and conditions  set forth herein,  the number of Shares
set forth on the last page of the Agreement to which these Terms and  Conditions
for  Purchase of Shares are attached as ANNEX I (the  "SIGNATURE  PAGE") for the
aggregate purchase price therefor set forth on the Signature Page.

                  2.2      The Company proposes to enter into substantially this
same form of  Subscription  Agreement  with certain other  investors (the "OTHER
INVESTORS")  and expects to complete  sales of Shares to them.  The Investor and
the Other Investors are hereinafter  sometimes  collectively  referred to as the
"INVESTORS," and this Agreement and the Subscription  Agreements executed by the
Other  Investors  are  hereinafter  sometimes  collectively  referred  to as the
"AGREEMENTS."

                  2.3      Investor  acknowledges that the Company has agreed to
pay Lazard Capital  Markets LLC (the  "PLACEMENT  AGENT") a fee (the  "PLACEMENT
FEE") in respect of the sale of Shares to the Investor.

                  2.4      The  Company  has  entered  into  a  Placement  Agent
Agreement,  dated  December  14,  2006  (the  "PLACEMENT  AGREEMENT"),  with the
Placement Agent that contains certain representations, warranties, covenants and
agreements of the Company that may be relied upon by the  Investor,  which shall
be a third party beneficiary thereof.

         3.       CLOSINGS AND DELIVERY OF THE SHARES AND FUNDS.

                  3.1      CLOSING.  The  completion of the purchase and sale of
the Shares (the "CLOSING")  shall occur at a place and time (the "CLOSING DATE")
to be  specified  by the  Company  and the  Placement  Agent,  and of which  the
Investors will be notified in advance by the Placement Agent, in accordance with
Rule 15c6-1  promulgated  under the Securities  Exchange Act of 1934, as amended
(the "EXCHANGE  ACT"). At the Closing,  (a) the Company shall cause the Transfer
Agent to deliver to the Investor the number of Shares set forth on the Signature
Page  registered in the name of the Investor or, if so indicated on the Investor
Questionnaire  attached hereto as EXHIBIT A, in the name of a nominee designated
by the  Investor  and (b) the  aggregate  purchase  price for the  Shares  being
purchased by the  Investor  will be delivered by or on behalf of the Investor to
the Company.

                  3.2      CONDITIONS  TO THE  COMPANY'S  OBLIGATIONS.  (a)  The
Company's  obligation  to issue  and sell the  Shares to the  Investor  shall be
subject to: (i) the receipt by the Company of the purchase  price for the Shares
being  purchased  hereunder  as set  forth  on the  Signature  Page and (ii) the
accuracy of the  representations  and  warranties  made by the  Investor and the
fulfillment of those  undertakings  of the Investor to be fulfilled prior to the
Closing Date.

                                     - 5 -


                           (b)      CONDITIONS  TO THE  INVESTOR'S  OBLIGATIONS.
The Investor's obligation to purchase the Shares will be subject to the accuracy
of the representations and warranties made by the Company and the fulfillment of
those  undertakings  of the Company to be fulfilled  prior to the Closing  Date,
including  without  limitation,  those  contained  in  this  Agreement  and  the
Placement  Agreement,  and to the condition  that the Placement  Agent shall not
have: (a) terminated  the Placement  Agreement  pursuant to the terms thereof or
(b)  determined  that the  conditions to the closing in the Placement  Agreement
have  not  been  satisfied.   The  Investor's   obligations  are  expressly  not
conditioned  on the purchase by any or all of the Other  Investors of the Shares
that they have agreed to purchase from the Company.

                  3.3      DELIVERY OF FUNDS.

                           (a)      DELIVERY  BY  ELECTRONIC  BOOK-ENTRY  AT THE
DEPOSITORY TRUST COMPANY.  If the Investor elects to settle the Shares purchased
by such Investor through delivery by electronic book-entry at DTC, NO LATER THAN
ONE (1) BUSINESS DAY AFTER THE  EXECUTION OF THIS  AGREEMENT BY THE INVESTOR AND
THE COMPANY, the Investor shall remit by wire transfer the amount of funds equal
to the aggregate  purchase price for the Shares being  purchased by the Investor
to the  following  account  designated  by the Company and the  Placement  Agent
pursuant to the terms of that certain Escrow Agreement (the "ESCROW  AGREEMENT")
dated as of December 14, 2006, by and among the Company, the Placement Agent and
Thelen Reid Brown Raysman & Steiner LLP (the "ESCROW AGENT"):

                   THE CITIBANK PRIVATE BANK
                   666 Fifth Avenue, 5th Floor
                   New York, NY 10103
                   ABA # 021-000-089
                   Account Name: Thelen Reid Brown Raysman & Steiner LLP, escrow
                   agent for the account of Enzo Biochem, Inc.
                   Account Number: 9970183451


                           Such funds shall be held in escrow  until the Closing
and delivered by the Escrow Agent on behalf of the Investors to the Company upon
the satisfaction, in the sole judgment of the Placement Agent, of the conditions
set forth in Section 3.2(b) hereof.  The Placement Agent shall have no rights in
or to any of the escrowed funds, unless the Placement Agent and the Escrow Agent
are  notified in writing by the Company in  connection  with the Closing  that a
portion of the escrowed funds shall be applied to the Placement Fee. The Company
and the Investor  agree to indemnify and hold the Escrow Agent harmless from and
against any and all losses,  costs,  damages,  expenses  and claims  (including,
without  limitation,  court  costs and  reasonable  attorneys  fees)  ("LOSSES")
arising  under this SECTION 3.3 or  otherwise  with respect to the funds held in
escrow  pursuant  hereto or  arising  under the Escrow  Agreement,  unless it is
finally   determined  that  such  Losses  resulted  directly  from  the  willful
misconduct or gross  negligence of the Escrow Agent.  Anything in this Agreement
to the  contrary  notwithstanding,  in no event shall the Escrow Agent be liable
for any special, indirect or consequential loss or damage of any kind whatsoever
(including but not limited to lost  profits),  even if the Escrow Agent has been
advised of the  likelihood of such loss or damage and  regardless of the form of
action.

                           Investor shall also furnish to the Placement  Agent a
completed  W-9 form (or, in the case of an Investor  who is not a United  States
citizen or resident, a W-8 form).

                                     - 6 -


                           Investor  acknowledges  that the Escrow Agent acts as
counsel  to the  Placement  Agent,  and  shall  have the  right to  continue  to
represent the Placement  Agent, in any action,  proceeding,  claim,  litigation,
dispute,  arbitration  or  negotiation  in  connection  with the  Offering,  and
Investor  hereby  consents  thereto and waives any  objection  to the  continued
representation  of  the  Placement  Agent  by the  Escrow  Agent  in  connection
therewith  based  upon  the  services  of the  Escrow  Agent  under  the  Escrow
Agreement,  without  waiving any duty or obligation the Escrow Agent may have to
any other person.

                           (b)      DELIVERY    VERSUS   PAYMENT   THROUGH   THE
DEPOSITORY TRUST COMPANY.  If the Investor elects to settle the Shares purchased
by such Investor by delivery  versus payment  through DTC, NO LATER THAN ONE (1)
BUSINESS  DAY AFTER THE  EXECUTION  OF THIS  AGREEMENT  BY THE  INVESTOR AND THE
COMPANY,  the  Investor  shall  confirm  that the  account or accounts at Lazard
Capital  Markets LLC ("LCM") to be credited  with the Shares being  purchased by
the Investor have a minimum  balance equal to the aggregate  purchase  price for
the Shares being purchased by the Investor.

                  3.4      DELIVERY OF SHARES.

                           (a)      DELIVERY  BY  ELECTRONIC  BOOK-ENTRY  AT THE
DEPOSITORY TRUST COMPANY.  If the Investor elects to settle the Shares purchased
by such Investor through delivery by electronic book-entry at DTC, NO LATER THAN
ONE (1) BUSINESS DAY AFTER THE  EXECUTION OF THIS  AGREEMENT BY THE INVESTOR AND
THE COMPANY, the Investor shall direct the broker-dealer at which the account or
accounts to be credited  with the Shares being  purchased  by such  Investor are
maintained,  which  broker/dealer  shall  be a  DTC  participant,  to  set  up a
Deposit/Withdrawal  at Custodian ("DWAC")  instructing American Stock Transfer &
Trust Company,  the Company's transfer agent, to credit such account or accounts
with the Shares by means of an electronic  book-entry delivery.  Such DWAC shall
indicate the settlement date for the deposit of the Shares,  which date shall be
provided  to the  Investor  by the  Placement  Agent.  Simultaneously  with  the
delivery to the Company by the Escrow Agent of the funds held in escrow pursuant
to SECTION 3.3 above,  the Company shall direct its transfer agent to credit the
Investor's  account or  accounts  with the Shares  pursuant  to the  information
contained in the DWAC.

                           (b)      DELIVERY    VERSUS   PAYMENT   THROUGH   THE
DEPOSITORY TRUST COMPANY.  If the Investor elects to settle the Shares purchased
by such Investor by delivery  versus payment  through DTC, NO LATER THAN ONE (1)
BUSINESS  DAY AFTER THE  EXECUTION  OF THIS  AGREEMENT  BY THE  INVESTOR AND THE
COMPANY,  the Investor  shall notify LCM of the account or accounts at LCM to be
credited with the Shares being purchased by such Investor.  On the Closing Date,
the Company shall deliver the Shares to the Investor through DTC directly to the
account(s) at LCM identified by Investor and  simultaneously  therewith  payment
shall be made by LCM by wire transfer to the Company.

         4.       REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE INVESTOR.

         The Investor  represents  and warrants to, and agrees with, the Company
and the Placement Agent that:

                  4.1      The Investor (a) is knowledgeable,  sophisticated and
experienced  in making,  and is  qualified  to make  decisions  with respect to,
investments  in shares  presenting an investment  decision like that involved in
the purchase of the Shares,  including  investments in securities  issued by the
Company and investments in comparable companies,  (b) has answered all questions
on the Signature Page and the Investor Questionnaire and the answers thereto are
true and correct as of the date hereof

                                     - 7 -


and will be true and correct as of the Closing Date and (c) in  connection  with
its decision to purchase the number of Shares set forth on the  Signature  Page,
has received  and is relying only upon the  Disclosure  Package,  the  documents
incorporated by reference therein and the Offering Information.

                  4.2      If the Investor is outside the United States, it will
comply with all applicable laws and regulations in each foreign  jurisdiction in
which it purchases, offers, sells or delivers Shares or has in its possession or
distributes any offering material, in all cases at its own expense.

                  4.3      (a) The Investor has full right, power, authority and
capacity  to enter  into  this  Agreement  and to  consummate  the  transactions
contemplated  hereby  and has  taken  all  necessary  action  to  authorize  the
execution,  delivery and performance of this  Agreement,  and (b) this Agreement
constitutes a valid and binding obligation of the Investor  enforceable  against
the  Investor in  accordance  with its terms,  except as  enforceability  may be
limited by  applicable  bankruptcy,  insolvency,  reorganization,  moratorium or
similar laws affecting  creditors' and contracting parties' rights generally and
except  as  enforceability  may be  subject  to  general  principles  of  equity
(regardless  of whether such  enforceability  is  considered  in a proceeding in
equity  or at  law)  and  except  as to  the  enforceability  of any  rights  to
indemnification  or  contribution  that may be  violative  of the public  policy
underlying  any  law,  rule  or  regulation  (including  any  federal  or  state
securities law, rule or regulation).

                  4.4      The  Investor   understands   that  nothing  in  this
Agreement,  the Prospectus or any other  materials  presented to the Investor in
connection with the purchase and sale of the Shares  constitutes  legal,  tax or
investment  advice.  The Investor has consulted  such legal,  tax and investment
advisors as it, in its sole  discretion,  has deemed necessary or appropriate in
connection with its purchase of Shares.

                  4.5      Since the date on which  the  Placement  Agent  first
contacted  such  Investor  about  the  Offering,  it  has  not  engaged  in  any
transactions in the securities of the Company  (including,  without  limitation,
any Short Sales  involving the Company's  securities).  Each Investor  covenants
that it will not engage in any  transactions  in the  securities  of the Company
(including Short Sales) prior to the time that the transactions  contemplated by
this Agreement are publicly disclosed. Each Investor agrees that it will not use
any of the  Shares  acquired  pursuant  to this  Agreement  to cover  any  short
position in the Common  Stock if doing so would be in  violation  of  applicable
securities laws. For purposes hereof, "Short Sales" include, without limitation,
all "short sales" as defined in Rule 200 promulgated  under Regulation SHO under
the  Exchange  Act,  whether or not against the box, and all types of direct and
indirect stock pledges,  forward sales contracts,  options,  puts, calls,  short
sales, swaps, "put equivalent  positions" (as defined in Rule 16a-1(h) under the
Exchange Act) and similar arrangements  (including on a total return basis), and
sales and other transactions  through non-US broker dealers or foreign regulated
brokers.

         5.       SURVIVAL OF REPRESENTATIONS,  WARRANTIES AND AGREEMENTS; THIRD
PARTY BENEFICIARY.  Notwithstanding  any investigation made by any party to this
Agreement or by the Placement Agent, all covenants, agreements,  representations
and  warranties  made by the Company and the  Investor  herein will  survive the
execution  of this  Agreement,  the delivery to the Investor of the Shares being
purchased and the payment therefor.  The Placement Agent and Lazard Freres & Co.
shall  be  third  party  beneficiaries  with  respect  to  the  representations,
warranties and agreements of the Investor in Section 4 hereof.

                                     - 8 -


         6.       NOTICES.   All   notices,   requests,   consents   and   other
communications  hereunder  will be in writing,  will be mailed (a) if within the
domestic  United  States by  first-class  registered  or certified  airmail,  or
nationally  recognized  overnight  express  courier,   postage  prepaid,  or  by
facsimile or (b) if delivered from outside the United States,  by  International
Federal  Express or  facsimile,  and will be deemed  given (i) if  delivered  by
first-class registered or certified mail domestic,  three business days after so
mailed,  (ii) if delivered  by  nationally  recognized  overnight  carrier,  one
business  day after so  mailed,  (iii) if  delivered  by  International  Federal
Express,  two business  days after so mailed and (iv) if delivered by facsimile,
upon  electric  confirmation  of receipt and will be delivered  and addressed as
follows:

            (a)  IF TO THE COMPANY, TO:

                 Enzo Biochem, Inc.
                 527 Madison Ave.
                 New York, NY 10022
                 Attention:  Barry Weiner, President and Chief Financial Officer
                 Facsimile:  212-583-0150


                 WITH COPIES TO:

                 Greenberg Traurig, LLP
                 MetLife Building
                 200 Park Avenue
                 New York, NY 10166
                 Attention: Robert H. Cohen
                 Facsimile:  212-801-6400

             (b) if to the  Investor,  at its  address  on  the  Signature  Page
         hereto,  or at  such  other  address  or  addresses  as may  have  been
         furnished to the Company in writing.

         7.       CHANGES.  This Agreement may not be modified or amended except
pursuant to an instrument in writing signed by the Company and the Investor.

         8.       HEADINGS.  The  headings  of  the  various  sections  of  this
Agreement  have been inserted for  convenience of reference only and will not be
deemed to be part of this Agreement.

         9.       SEVERABILITY.   In  case  any  provision   contained  in  this
Agreement  should be  invalid,  illegal or  unenforceable  in any  respect,  the
validity,  legality and  enforceability  of the remaining  provisions  contained
herein will not in any way be affected or impaired thereby.

         10.      GOVERNING  LAW.  This  Agreement  will  be  governed  by,  and
construed  in  accordance  with,  the  internal  laws of the  State of New York,
without  giving effect to the  principles of conflicts of law that would require
the application of the laws of any other jurisdiction.

         11.      COUNTERPARTS.  This  Agreement  may be executed in two or more
counterparts,  each of which will constitute an original, but all of which, when
taken together,  will constitute but one instrument,  and will become  effective
when  one or more  counterparts  have  been  signed  by each  party  hereto  and
delivered to the other parties. The Company and the Investor acknowledge

                                     - 9 -


and agree that the Company shall deliver its  counterpart  to the Investor along
with the  Prospectus  Supplement  (or the filing by the Company of an electronic
version thereof with the Commission).

         12.      CONFIRMATION  OF SALE.  The Investor  acknowledges  and agrees
that such  Investor's  receipt of the Company's  counterpart to this  Agreement,
together  with the  Prospectus  Supplement  (or the filing by the  Company of an
electronic  version  thereof  with the  Commission),  shall  constitute  written
confirmation of the Company's sale of Shares to such Investor.

         13.      PRESS  RELEASE.  The Company and the  Investor  agree that the
Company shall issue a press release announcing the Offering prior to the opening
of the financial  markets in New York City on the business day immediately after
the date hereof.

         14.      TERMINATION.  In the event  that the  Placement  Agreement  is
terminated by the Placement Agent pursuant to the terms thereof,  this Agreement
shall terminate without any further action on the part of the parties hereto.

                                     - 10 -


                                    EXHIBIT A

                               ENZO BIOCHEM, INC.

                             INVESTOR QUESTIONNAIRE


         Pursuant to SECTION 3 of ANNEX I to the  Agreement,  please  provide us
with the following information:


1.       The exact name that your Shares are          __________________________
         to be registered in. You may use a
         nominee name if appropriate:

2.       The relationship between the                 __________________________
         Investor and the registered holder
         listed in response to item 1 above:

3.       The mailing address of the                   __________________________
         registered holder listed in response
         to item 1 above:

4.       The Social Security Number or Tax            __________________________
         Identification Number of the
         registered holder listed in the
         response to item 1 above:

5.       Name of DTC Participant                      __________________________
         (broker-dealer at which the account
         or accounts to be credited with the
         Shares are maintained):

6.       DTC Participant Number:                      __________________________

7.       Name of Account at DTC Participant           __________________________
         being credited with the Shares:

8.       Account Number at DTC Participant            __________________________
         being credited with the Shares: