Exhibit 10.1



                             SUBSCRIPTION AGREEMENT


Enzo Biochem, Inc.
527 Madison Ave.
New York, NY 10022

Gentlemen:

The  undersigned  (the  "INVESTOR")  hereby  confirms its agreement  with you as
follows:

     1. This  Subscription  Agreement (this  "AGREEMENT") is made as of the date
set  forth  below  between  Enzo  Biochem,  Inc.,  a New York  corporation  (the
"COMPANY"), and the Investor.

     2. The Company has  authorized  the sale and issuance to the Investor of up
to an aggregate  of 1,000,000  shares (the  "SHARES") of its Common  Stock,  par
value  $0.01 per share  (the  "COMMON  STOCK"),  subject  to  adjustment  by the
Company's Board of Directors,  or a committee  thereof,  for a purchase price of
$15.00 per share (the "PURCHASE PRICE").

     3. The  offering  and sale of the Shares  (the  "OFFERING")  are being made
pursuant to (1) an effective  Registration  Statement on Form S-3 (including the
Prospectus   contained  therein  (the  "BASE  PROSPECTUS"),   the  "REGISTRATION
STATEMENT")  filed by the Company with the  Securities  and Exchange  Commission
(the "COMMISSION"),  (2) if applicable,  certain "free writing prospectuses" (as
that term is defined in Rule 405 under the  Securities Act of 1933, as amended),
that  have  been or will be  filed  with the  Commission  and  delivered  to the
Investor on or prior to the date  hereof and (3) a  Prospectus  Supplement  (the
"PROSPECTUS SUPPLEMENT" and together with the Base Prospectus, the "PROSPECTUS")
containing certain  supplemental  information  regarding the Shares and terms of
the  Offering  that  will be filed  with the  Commission  and  delivered  to the
Investor  (or made  available to the Investor by the filing by the Company of an
electronic version thereof with the Commission).

     4. The Company and the Investor  agree that the Investor will purchase from
the Company and the Company  will issue and sell to the  Investor  the Shares of
Common Stock set forth below for the aggregate  purchase  price set forth below.
The Shares shall be purchased  pursuant to the Terms and Conditions for Purchase
of Shares attached hereto as ANNEX I and  incorporated  herein by this reference
as if fully set forth herein. The Investor acknowledges that the Offering is not
being  underwritten by the placement agent (the "PLACEMENT  AGENT") named in the
Prospectus Supplement and that there is no minimum offering amount.

     5. The manner of settlement of the Shares  purchased by the Investor  shall
be Delivery versus Payment ("DVP") through The Depository  Trust Company ("DTC")
(i.e.,  the Company shall deliver Shares  registered in the Investor's  name and
address as set forth below and released by the American  Stock  Transfer & Trust
Company,  the Company's  transfer agent (the  "TRANSFER  AGENT") to the Investor
through DTC at the Closing  directly to the account(s) at Lazard Capital Markets
LLC ("LCM")  identified  by the Investor and  simultaneously  therewith  payment
shall be made by LCM by wire  transfer  to the  Company).  NO LATER THAN ONE (1)
BUSINESS  DAY AFTER THE





EXECUTION OF THIS AGREEMENT BY THE INVESTOR AND THE COMPANY, THE INVESTOR SHALL:

         (I)  NOTIFY LCM OF THE ACCOUNT OR  ACCOUNTS AT LCM TO BE CREDITED  WITH
              THE SHARES BEING PURCHASED BY SUCH INVESTOR, AND

         (II)  CONFIRM  THAT THE ACCOUNT OR ACCOUNTS AT LCM TO BE CREDITED  WITH
               THE SHARES BEING PURCHASED BY THE INVESTOR HAVE A MINIMUM BALANCE
               EQUAL  TO THE  AGGREGATE  PURCHASE PRICE  FOR  THE  SHARES  BEING
               PURCHASED BY THE INVESTOR.

IT IS THE INVESTOR'S RESPONSIBILITY TO (A) CONFIRM THE PROPER ACCOUNT BALANCE IN
A TIMELY MANNER AND (B) ARRANGE FOR SETTLEMENT BY DVP IN A TIMELY MANNER. IF THE
INVESTOR  DOES NOT DELIVER THE AGGREGATE  PURCHASE  PRICE FOR THE SHARES OR DOES
NOT MAKE PROPER  ARRANGEMENTS FOR SETTLEMENT IN A TIMELY MANNER,  THE SHARES MAY
NOT BE DELIVERED AT CLOSING TO THE INVESTOR OR THE INVESTOR MAY BE EXCLUDED FROM
THE CLOSING ALTOGETHER.

     6. The Investor  represents that, except as set forth below, (a) it has had
no position,  office or other material  relationship within the past three years
with the Company or persons known to it to be affiliates of the Company,  (b) it
is not a NASD member or an Associated  Person (as such term is defined under the
NASD Membership and Registration Rules Section 1011) as of the Closing,  and (c)
neither the  Investor  nor any group of  Investors  (as  identified  in a public
filing made with the  Commission)  of which the Investor is a part in connection
with the Offering of the Shares, acquired, or obtained the right to acquire, 20%
or more of the Common Stock (or securities  convertible  into or exercisable for
Common  Stock) or the voting power of the Company on a  post-transaction  basis.
Exceptions:

- --------------------------------------------------------------------------------

        (If no exceptions, write "none." If left blank, response will be
                              deemed to be "none.")

     7. The Investor  represents  that it has received  (or  otherwise  had made
available to it by the filing by the Company of an  electronic  version  thereof
with the Commission)  the Base  Prospectus,  dated November 3, 2006,  which is a
part of the Company's  Registration  Statement,  the documents  incorporated  by
reference therein and any free writing prospectus (collectively, the "DISCLOSURE
PACKAGE"),  prior to or in connection  with the receipt of this  Agreement.  The
Investor  acknowledges  that,  prior to the  delivery of this  Agreement  to the
Company, the Investor will receive certain additional  information regarding the
Offering,  including  pricing  information  (the "OFFERING  INFORMATION").  Such
information  may be provided to the  Investor by any means  permitted  under the
Act,  including the Prospectus  Supplement,  a free writing  prospectus and oral
communications.

     8. No offer by the  Investor to buy Shares will be accepted  and no part of
the  Purchase  Price will be  delivered  to the Company  until the  Investor has
received the  Offering  Information  and the Company has accepted  such offer by
countersigning a copy of this Agreement,  and any such offer may be withdrawn or
revoked,  without obligation or commitment of any kind, at any time prior to the
Company (or a Placement  Agent on behalf of the  Company)  sending  (orally,  in
writing or by  electronic  mail)  notice of its  acceptance  of such  offer.  An
indication  of interest  will involve no  obligation  or


                                     - 2 -


commitment  of any kind  until the  Investor  has been  delivered  the  Offering
Information and this Agreement is accepted and  countersigned by or on behalf of
the Company.

















                                     - 3 -




Number of Shares:
                 ---------------------------------------------------

Purchase Price Per Share: $
                           --------------------------------------------

Aggregate Purchase Price: $
                           --------------------------------------------


     Please confirm that the foregoing correctly sets forth the agreement
between us by signing in the space provided below for that purpose.



                                   Dated as of:  February 2, 2007


                                   ---------------------------------------------
                                   INVESTOR

                                   By:
                                      ------------------------------------------
                                   Print Name:
                                              ----------------------------------
                                   Title:
                                         ---------------------------------------
                                   Address:

                                   ---------------------------------------------



Agreed and Accepted
this 2nd day of February, 2007:


ENZO BIOCHEM, INC.


By:
   --------------------------------------------------
Name:
Title:






                                     - 4 -




                                     ANNEX I

                   TERMS AND CONDITIONS FOR PURCHASE OF SHARES

         1.  AUTHORIZATION  AND SALE OF THE  SHARES.  Subject  to the  terms and
conditions of this Agreement, the Company has authorized the sale of the Shares.

         2.  AGREEMENT TO SELL AND PURCHASE THE SHARES; PLACEMENT AGENT.

             2.1 At the Closing (as defined in SECTION  3.1),  the Company  will
sell to the Investor,  and the Investor will purchase from the Company, upon the
terms and  conditions  set forth  herein,  the number of Shares set forth on the
last page of the Agreement to which these Terms and  Conditions  for Purchase of
Shares are attached as ANNEX I (the "SIGNATURE PAGE") for the aggregate purchase
price therefor set forth on the Signature Page.

             2.2 Investor acknowledges that the Company has agreed to pay Lazard
Capital  Markets  LLC (the  "PLACEMENT  AGENT") a fee (the  "PLACEMENT  FEE") in
respect of the sale of Shares to the Investor.

             2.3 The Company has entered into a Placement Agent Agreement, dated
February 2, 2007 (the  "PLACEMENT  AGREEMENT"),  with the  Placement  Agent that
contains certain  representations,  warranties,  covenants and agreements of the
Company  that may be relied upon by the  Investor,  which shall be a third party
beneficiary thereof.

         3.       CLOSINGS AND DELIVERY OF THE SHARES AND FUNDS.

             3.1 CLOSING.  The completion of the purchase and sale of the Shares
(the  "CLOSING")  shall  occur at a place  and time (the  "CLOSING  DATE") to be
specified by the Company and the Placement Agent, and of which the Investor will
be notified in advance by the Placement  Agent,  in accordance  with Rule 15c6-1
promulgated under the Securities Exchange Act of 1934, as amended (the "EXCHANGE
ACT"). At the Closing, (a) the Company shall cause the Transfer Agent to deliver
to the Investor,  pursuant to section 3.4 herein, the number of Shares set forth
on the Signature Page registered in the name of the Investor or, if so indicated
on the  Investor  Questionnaire  attached  hereto as EXHIBIT A, in the name of a
nominee  designated by the Investor and (b) the aggregate purchase price for the
Shares being  purchased by the Investor will be delivered by or on behalf of the
Investor to the Company.

             3.2  CONDITIONS  TO THE  COMPANY'S  OBLIGATIONS.  (a) The Company's
obligation to issue and sell the Shares to the Investor shall be subject to: (i)
the receipt by the Company of the purchase price for the Shares being  purchased
hereunder  as set  forth on the  Signature  Page and  (ii) the  accuracy  of the
representations and warranties made by the Investor and the fulfillment of those
undertakings of the Investor to be fulfilled prior to the Closing Date.

                  (b) CONDITIONS TO THE INVESTOR'S  OBLIGATIONS.  The Investor's
obligation  to  purchase  the  Shares  will be subject  to the  accuracy  of the
representations  and warranties made by the Company and the fulfillment of those
undertakings of the Company to be fulfilled prior to the Closing Date, including
without  limitation,  those  contained  in  this  Agreement  and  the  Placement
Agreement,  and to the condition  that the Placement  Agent shall not have:  (a)
terminated  the  Placement  Agreement


                                     - 5 -


pursuant  to the terms  thereof or (b)  determined  that the  conditions  to the
closing in the Placement Agreement have not been satisfied.

             3.3  DELIVERY  OF  FUNDS.   DELIVERY  VERSUS  PAYMENT  THROUGH  THE
DEPOSITORY TRUST COMPANY. NO LATER THAN ONE (1) BUSINESS DAY AFTER THE EXECUTION
OF THIS  AGREEMENT BY THE INVESTOR AND THE COMPANY,  the Investor  shall confirm
that the  account  or  accounts  at Lazard  Capital  Markets  LLC  ("LCM") to be
credited with the Shares being  purchased by the Investor have a minimum balance
equal to the  aggregate  purchase  price for the Shares  being  purchased by the
Investor.

             3.4  DELIVERY  OF  SHARES.  DELIVERY  VERSUS  PAYMENT  THROUGH  THE
DEPOSITORY TRUST COMPANY. NO LATER THAN ONE (1) BUSINESS DAY AFTER THE EXECUTION
OF THIS AGREEMENT BY THE INVESTOR AND THE COMPANY, the Investor shall notify LCM
of the account or accounts at LCM to be credited with the Shares being purchased
by such  Investor.  On the Closing Date, the Company shall deliver the Shares to
the  Investor  through  DTC  directly to the  account(s)  at LCM  identified  by
Investor  and  simultaneously  therewith  payment  shall  be made by LCM by wire
transfer to the Company.

         4.   REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE INVESTOR.

         The Investor  represents  and warrants to, and agrees with, the Company
and the Placement Agent that:

             4.1  The  Investor   (a)  is   knowledgeable,   sophisticated   and
experienced  in making,  and is  qualified  to make  decisions  with respect to,
investments  in shares  presenting an investment  decision like that involved in
the purchase of the Shares,  including  investments in securities  issued by the
Company and investments in comparable companies,  (b) has answered all questions
on the Signature Page and the Investor Questionnaire and the answers thereto are
true and  correct as of the date  hereof and will be true and  correct as of the
Closing Date and (c) in  connection  with its decision to purchase the number of
Shares set forth on the  Signature  Page,  has received and is relying only upon
the Disclosure Package, the documents  incorporated by reference therein and the
Offering Information.

             4.2 If the  Investor is outside the United  States,  it will comply
with all applicable laws and  regulations in each foreign  jurisdiction in which
it  purchases,  offers,  sells or delivers  Shares or has in its  possession  or
distributes any offering material, in all cases at its own expense.

             4.3 (a) The Investor has full right, power,  authority and capacity
to enter into this  Agreement and to consummate  the  transactions  contemplated
hereby and has taken all necessary  action to authorize the execution,  delivery
and  performance of this Agreement,  and (b) this Agreement  constitutes a valid
and binding  obligation  of the  Investor  enforceable  against the  Investor in
accordance with its terms, except as enforceability may be limited by applicable
bankruptcy,  insolvency,  reorganization,  moratorium or similar laws  affecting
creditors'   and   contracting   parties'   rights   generally   and  except  as
enforceability  may be subject to general  principles of equity  (regardless  of
whether such  enforceability  is considered in a proceeding in equity or at law)
and  except  as to  the  enforceability  of any  rights  to  indemnification  or
contribution that may be violative of the public policy underlying any law, rule
or  regulation   (including  any  federal  or  state  securities  law,  rule  or
regulation).

             4.4 The Investor  understands  that nothing in this Agreement,  the
Prospectus or any other  materials  presented to the Investor in connection with
the purchase and sale of the Shares constitutes legal, tax or investment


                                     - 6 -


advice.  The Investor has consulted such legal,  tax and investment  advisors as
it, in its sole  discretion,  has deemed  necessary or appropriate in connection
with its purchase of Shares.

             4.5 Since the date on which the  Placement  Agent  first  contacted
such Investor about the Offering,  it has not engaged in any transactions in the
securities  of the  Company  (including,  without  limitation,  any Short  Sales
involving the Company's  securities).  Each Investor  covenants that it will not
engage in any  transactions  in the securities of the Company  (including  Short
Sales) prior to the time that the  transactions  contemplated  by this Agreement
are publicly  disclosed.  Each  Investor  agrees that it will not use any of the
Shares  acquired  pursuant to this  Agreement to cover any short position in the
Common Stock if doing so would be in violation of  applicable  securities  laws.
For purposes  hereof,  "Short Sales"  include,  without  limitation,  all "short
sales"  as  defined  in Rule 200  promulgated  under  Regulation  SHO  under the
Exchange  Act,  whether  or not  against  the box,  and all types of direct  and
indirect stock pledges,  forward sales contracts,  options,  puts, calls,  short
sales, swaps, "put equivalent  positions" (as defined in Rule 16a-1(h) under the
Exchange Act) and similar arrangements  (including on a total return basis), and
sales and other transactions  through non-US broker dealers or foreign regulated
brokers.

             5. SURVIVAL OF  REPRESENTATIONS,  WARRANTIES AND AGREEMENTS;  THIRD
PARTY BENEFICIARY.  Notwithstanding  any investigation made by any party to this
Agreement or by the Placement Agent, all covenants, agreements,  representations
and  warranties  made by the Company and the  Investor  herein will  survive the
execution  of this  Agreement,  the delivery to the Investor of the Shares being
purchased and the payment therefor.  The Placement Agent and Lazard Freres & Co.
shall  be  third  party  beneficiaries  with  respect  to  the  representations,
warranties and agreements of the Investor in Section 4 hereof.

             6.   NOTICES.   All   notices,   requests,   consents   and   other
communications  hereunder  will be in writing,  will be mailed (a) if within the
domestic  United  States by  first-class  registered  or certified  airmail,  or
nationally  recognized  overnight  express  courier,   postage  prepaid,  or  by
facsimile or (b) if delivered from outside the United States,  by  International
Federal  Express or  facsimile,  and will be deemed  given (i) if  delivered  by
first-class registered or certified mail domestic,  three business days after so
mailed,  (ii) if delivered  by  nationally  recognized  overnight  carrier,  one
business  day after so  mailed,  (iii) if  delivered  by  International  Federal
Express,  two business  days after so mailed and (iv) if delivered by facsimile,
upon  electric  confirmation  of receipt and will be delivered  and addressed as
follows:

             (A) IF TO THE COMPANY, TO:

                 Enzo Biochem, Inc.
                 527 Madison Ave.
                 New York, NY 10022
                 Attention: Barry Weiner, President and Chief Financial Officer
                 Facsimile:  212-583-0150











                                     - 7 -


                 WITH COPIES TO:

                 Greenberg Traurig, LLP
                 MetLife Building
                 200 Park Avenue
                 New York, NY 10166
                 Attention: Robert H. Cohen
                 Facsimile:  212-801-6400

                  (b) if to the Investor,  at its address on the Signature  Page
             hereto,   or at  such  other  address or addresses as may have been
             furnished to the Company in writing.

         7.  CHANGES.  This  Agreement  may not be  modified  or amended  except
         pursuant  to an  instrument  in writing  signed by the  Company and the
         Investor.

         8.  HEADINGS.  The headings of the various  sections of this  Agreement
         have been inserted for  convenience  of reference  only and will not be
         deemed to be part of this Agreement.

         9.  SEVERABILITY.  In case any  provision  contained in this  Agreement
         should  be  invalid,  illegal  or  unenforceable  in any  respect,  the
         validity,  legality  and  enforceability  of the  remaining  provisions
         contained herein will not in any way be affected or impaired thereby.

         10. GOVERNING LAW. This Agreement will be governed by, and construed in
         accordance  with,  the internal laws of the State of New York,  without
         giving effect to the  principles of conflicts of law that would require
         the application of the laws of any other jurisdiction.

         11.  COUNTERPARTS.  This  Agreement  may be  executed  in  two or  more
         counterparts,  each of which will  constitute  an original,  but all of
         which,  when taken together,  will  constitute but one instrument,  and
         will become effective when one or more counterparts have been signed by
         each party hereto and delivered to the other  parties.  The Company and
         the Investor  acknowledge  and agree that the Company shall deliver its
         counterpart to the Investor  along with the  Prospectus  Supplement (or
         the filing by the Company of an  electronic  version  thereof  with the
         Commission).

         12.  CONFIRMATION  OF SALE. The Investor  acknowledges  and agrees that
         such Investor's receipt of the Company's counterpart to this Agreement,
         together with the  Prospectus  Supplement (or the filing by the Company
         of an electronic version thereof with the Commission), shall constitute
         written confirmation of the Company's sale of Shares to such Investor.

         13. PRESS RELEASE.  The Company and the Investor agree that the Company
         shall  issue a press  release  announcing  the  Offering  prior  to the
         opening of the  financial  markets in New York City on the business day
         immediately after the date hereof.

         14.  TERMINATION.   In  the  event  that  the  Placement  Agreement  is
         terminated by the Placement  Agent pursuant to the terms thereof,  this
         Agreement shall terminate without any further action on the part of the
         parties hereto.




                                     - 8 -





                                    EXHIBIT A

                               ENZO BIOCHEM, INC.

                             INVESTOR QUESTIONNAIRE

         Pursuant to SECTION 3 of ANNEX I to the  Agreement,  please  provide us
with the following information:

1.      The exact name that your Shares are to be
        registered in. You may use a nominee name     __________________________
        if appropriate:

2.      The relationship between the Investor and
        the registered  holder listed in response      _________________________
        to item 1 above:

3.      The  mailing  address  of the  registered
        holder  listed  in  response  to  item  1      _________________________
        above:

4.      The   Social   Security   Number  or  Tax
        Identification  Number of the  registered      _________________________
        holder  listed in the  response to item 1
        above: