[SHIP] [VANGUARD LOGO]


                                 April 22, 2005


Christian Sandoe, Esq.
Division of Investment Management
U.S. Securities and Exchange Commission                         VIA E-MAIL
450 Fifth Street, N.W., Fifth Floor
Washington, D.C. 20549

RE:  VANGUARD INSTITUTIONAL INDEX FUND (THE "TRUST"); FILE NO. 33-34494

Dear Mr. Sandoe:

     Thank you for your  comments of April 14, 2005  regarding  the Trust's 39th
Post-Effective  Amendment  to the  Registration  Statement  that  was  filed  on
February 28, 2005  pursuant to Rule 485(a).  The  following are our responses to
each of your comments.  Each prospectus  page reference is to the  Institutional
Shares and Institutional Plus Shares version of the prospectus.


Comment 1:   ADDITION OF MID-CAP  RISK IN  INSTITUTIONAL  TOTAL  STOCK  MARKET
             INDEX FUND (PAGE 3)

Comment:     If the  Institutional  Total Stock  Market Index Fund (the "Stock
             Fund") invests in mid-cap stocks, move mid-cap risk disclosure to
             the Primary Risks section of the prospectus.

Response:    Item 2 of Form N-1A requires a summary of "the principal risks of
             investing  in the Fund,  including  the risks to which the Fund's
             portfolio as a whole is subject" (emphasis added).  This requires
             disclosure of the risks of a fund's overall portfolio,  not every
             risk  associated with each type of security held by the fund. The
             Commission's approach to risk disclosure is succinctly summarized
             in the 1998  release  adopting  sweeping  revisions  to Form N-1A
             (Investment  Company Act Release No. 23064 (March 13, 1998). Part
             II.A.3.b  of the  release  states  "disclosure  about  the  risks
             associated  with  each  type of  security  in which  the fund may
             invest  does  not  effectively  communicate  to  [investors]  the
             overall risks of investing in the fund. In the Commission's view,
             disclosing  the  risks  of each  possible  portfolio  investment,
             rather than the overall  risks of investing  in a fund,  does not
             help investors evaluate a particular fund or compare the risks of
             the fund with those of other funds."




Mr. Christian Sandoe
April 22, 2005
Page 2 of 3



             Applying the Commission's position to the Stock Fund, we conclude
             that  disclosing  mid-cap  risk in Item 2 would  not  effectively
             communicate the overall risks of investing in the Stock Fund. The
             risk of investing in funds focused on mid- or small-cap stocks is
             that their returns can be more volatile than the returns of funds
             investing  in  large-cap  stocks.  This  risk,  however,  is  not
             significant  for the Stock Fund for two primary  reasons.  First,
             large-capitalization  stocks  constitute the preponderance of the
             Stock Fund's assets. Second, the Stock Fund's limited exposure to
             mid-and  small-cap  stocks is spread across the whole universe of
             domestic stocks.  The result of this  diversification is to limit
             sector-specific and stock-specific risk, including mid-cap risk.

             The  modest,  and broad,  exposure to mid- and  small-cap  stocks
             actually  served to reduce the  volatility  of  returns.  For the
             36-month  period ended March 31, 2005,  the Stock Fund had a beta
             of 1.00 versus the Dow Jones Wilshire 5000 Composite Index (i.e.,
             matched the volatility  exactly).  Relative to the S&P 500 Index,
             the Stock Fund's beta was 0.98%  (i.e.,  slightly  less  volatile
             than the large-cap-only S&P 500 Index).

             Highlighting  the  potential  volatility  of a  relatively  small
             portion of the Stock Fund's holdings in the Primary Risks section
             of the prospectus would be inappropriate, potentially misleading,
             and contrary to the intent of the Commission.

COMMENT 2:   INVESTMENT ADVISOR CLARIFICATION (PAGE 36)

Comment:     In the  Investment  Advisor  section  of the  prospectus,  better
             clarify  that  George  Sauter  oversees,  rather  than  does  the
             day-to-day management, of the Funds within the Trust.

Response:    We believe that the disclosure is clear as written. The paragraph
             describing  Mr.  Sauter  states  that he is  responsible  for the
             "oversight of  approximately  $530 billion  managed by Vanguard's
             Quantitative  Equity and Fixed Income Groups."  Furthermore,  the
             introduction  to the  "Plain  Talk  About  The  Funds'  Portfolio
             Managers"  clearly  states  that the  individuals  listed  in the
             highlighted  "Plain Talk" box are "primarily  responsible for the
             day-to-day  management of the Funds' portfolios." In light of our
             clear statements  about the roles of each  individual,  we do not
             believe that it is  necessary  to state that Mr.  Sauter does not
             have day-to-day management responsibilities for the Funds.

COMMENT 3:   REVISE  BOARD  REVIEW OF  ADVISORY  CONTRACTS  (PAGE  B-29 IN THE
             STATEMENT OF ADDITIONAL INFORMATION ("SAI"))

Comment:     Add disclosure to the SAI that relates the factors  considered by
             each Fund's board in reviewing  investment advisory agreements to
             the particulars of each Fund,  pursuant to Item 12(b)(10) of Form
             N-1A.



Mr. Christian Sandoe
April 22, 2005
Page 3 of 3


Response:    Item 12(b)(10)  requires  funds to "discuss in reasonable  detail
             the material  factors and the  conclusions  with respect  thereto
             that formed the basis for the board of  directors  approving  the
             existing  investment  advisory  contract."  We have  revised  our
             existing  disclosure   regarding  board  approval  of  investment
             advisory agreements.

             We propose to revise the relevant SAI  disclosure as indicated in
             Appendix  A  to  this  letter.  Please  note  that  the  proposed
             disclosure  in Appendix A is subject to  editorial  revision  and
             completion.

COMMENT 4:    TANDY REQUIREMENTS

Comment:     The SEC is now requiring all  registrants  to provide at the
             end of response letters to registration  statement comments,
             the following statements:


             o    Each Fund is  responsible  for the  adequacy and accuracy of
                  the disclosure in the filing.

             o    Staff  comments or changes in response to staff  comments in
                  the  filings  reviewed  by the  staff do not  foreclose  the
                  Commission  from  taking  any  action  with  respect  to the
                  filing.

             o    Each Fund may not assert staff  comments as a defense in any
                  proceeding  initiated by the  Commission or any person under
                  the federal securities laws of the United States.

Response:    As  required  by  the  SEC,   we  will   provide  the   foregoing
             acknowledgements.

                                    * * * * *

             As required by the SEC, the Funds acknowledge that:

             o    The Funds are  responsible  for the adequacy and accuracy of
                  the disclosure in the filing.

             o    Staff  comments or changes in response to staff  comments in
                  the  filings  reviewed  by the  staff do not  foreclose  the
                  Commission  from  taking  any  action  with  respect  to the
                  filing.

             o    The Funds may not assert staff  comments as a defense in any
                  proceeding  initiated by the  Commission or any person under
                  the federal securities laws of the United States.

             Please  call  me at  (610)  669-5284  if  you  have  any  further
             questions.

                                   Sincerely,


                                Lisa L. B. Matson
                                Associate Counsel
                                The Vanguard Group, Inc.


Enclosure


                                   APPENDIX A


PROHIBITIONS ON RECEIPT OF COMPENSATION OR OTHER CONSIDERATION

The Policies and Procedures  prohibit a Vanguard  fund, its investment  advisor,
and any other person to pay or receive any  compensation or other  consideration
of any type for the purpose of obtaining  disclosure of Vanguard fund  portfolio
holdings or other investment positions.  "Consideration"  includes any agreement
to  maintain  assets in the fund or in other  investment  companies  or accounts
managed by the investment  advisor or by any affiliated person of the investment
advisor.

BOARD REVIEW OF INVESTMENT ADVISORY ARRANGEMENTS

Each Fund's board of trustees  oversees the Fund's management and performance on
a regular basis. In addition, the board considers annually whether each Fund and
its shareholders continue to benefit from the internalized  management structure
whereby  the  Fund  receives  investment  management  services  from  Vanguard's
Quantitative Equity and Fixed Income Groups (the Groups).  Vanguard provides the
board with monthly,  quarterly,  and annual analyses of the Groups' performance.
In addition,  Vanguard  provides the board with quarterly  self-evaluations  and
certain other  information  the board deems important to evaluate the short- and
long-term  performance  of each  Fund's  internalized  management.  Each  Fund's
portfolio  managers meet with the board  periodically  to discuss the management
and performance of the Fund.

     When considering whether to continue the internalized  management structure
of each Fund,  the board  examines  several  factors,  but does not identify any
particular  factor as  controlling  their  decision.  The board also reviews the
investment  performance  of each Fund compared with a peer group of funds and an
appropriate index.

     After  reviewing  and  considering  various  factors as they  relate to the
Funds,  the board  determines  whether it would be in the best  interests of the
respective   fund   shareholders   to  continue  the   internalized   management
arrangement.

     In its most recent review of each Fund's advisory  arrangements,  the board
identified no single factor that controlled their decision.  The primary factors
underlying the board's  determination to renew each Fund's advisory arrangements
were as follows:

VANGUARD INSTITUTIONAL INDEX FUND

The board  considered the following  factors when  determining  whether Vanguard
should continue providing  internalized  investment  management  services to the
Fund:

- -    The nature, extent, and quality of the services provided.

- -    The investment performance of the Fund's assets managed by Vanguard.

- -    The fair market value of the services provided.

- -    A  comparative  analysis of expense  ratios of, and advisory  fees paid by,
     similar funds.

- -    Vanguard's control of the operating expenses of the Fund.

     The specific Fund  performance and advisory fee  information  considered by
the board included the following:




                                                                                                
                                                 AVERAGE ANNUAL RETURN (BEFORE TAXES)
                                                 ------------------------------------

                                                                                                                    ADVISORY FEES
                                                                                                                  EXPRESSED AS AN
                                                                   5 YEARS       10 YEARS                        ANNUAL EFFECTIVE
                                             1 YEAR ENDED            ENDED          ENDED                      RATE OF THE FUNDS'
                                               12/31/2004       12/31/2004     12/31/2004    EXPENSE RATIO      AVERAGE NET ASSET
                                               ----------       ----------     ----------    -------------      -----------------
VANGUARD INSTITUTIONAL INDEX FUND
 INSTITUTIONAL SHARES*                             10.86%           -2.26%         12.13%            0.05%                  0.02%
Average Large-Cap Core Fund**                       7.79            -4.05           9.82             1.45                   0.61
Standard & Poor's 500 Index                        10.88            -2.30          12.07              N/A                    N/A

*    Information  about  the  Fund's  Institutional  Plus  Shares  may be  found
     elsewhere in this Statement of Additional information.
**   Derived from data provided by Lipper Inc.



- -    The  board   considered   the  Fund's  short-  and   long-term   investment
     performance,  which is disclosed in the table  above.  The board  concluded
     that the Fund  outperformed the average large-cap core fund over the short-
     and long-term, and performed at or near its benchmark index.


                                      B-33


- -    The board concluded that, in the aggregate, the nature, extent, and quality
     of services  provided by  Vanguard to the Fund are  appropriate  and should
     continue.

- -    The  board  assessed  the  advisory  expenses  incurred  by  the  Fund  and
     considered  the fair market value of the services  provided in light of the
     expenses  incurred.  The board  concluded  that the expenses  incurred were
     significantly  less  than the  average  advisory  fee paid by others in the
     Fund's Lipper peer group.

- -    Based  upon  its  most  recent  evaluation  of the  investment  staff,  the
     portfolio   management  process,  the  investment   performance,   and  the
     internalized management arrangements, the board of the Fund determined that
     it would be in the best  interests of the Fund's  shareholders  to continue
     its internalized management arrangement.

- -    Finally,  the board considered  whether the Fund should obtain  alternative
     portfolio   management   services  and  concluded   that,   under  all  the
     circumstances  and  based  on its  informed  business  judgment,  the  most
     appropriate   course  of  action  in  the  best  interests  of  the  Fund's
     shareholders  to was continue the investment  management  arrangement  with
     Vanguard.

VANGUARD INSTITUTIONAL TOTAL STOCK MARKET INDEX FUND

The board  considered the following  factors when  determining  whether Vanguard
should continue providing  internalized  investment  management  services to the
Fund:

- -    The nature, extent, and quality of the services provided.

- -    The investment performance of the Fund's assets managed by Vanguard.

- -    The fair market value of the services provided.

- -    A  comparative  analysis of expense  ratios of, and advisory  fees paid by,
     similar funds.

- -    Vanguard's control of the operating expenses of the Fund.

     The specific Fund  performance and advisory fee  information  considered by
the board included the following:


                                                                                                
                                             AVERAGE ANNUAL RETURN (BEFORE TAXES)
                                             ------------------------------------

                                                           5 YEARS               10 YEARS                           ADVISORY FEES
                                                         (or since              (or since                         EXPRESSED AS AN
                                                        inception)             inception)                        ANNUAL EFFECTIVE
                                1 YEAR ENDED                 ENDED                  ENDED                      RATE OF THE FUNDS'
                                  12/31/2004            12/31/2004             12/31/2004    EXPENSE RATIO      AVERAGE NET ASSET
                                  ----------            ----------             ----------    -------------      -----------------
VANGUARD INSTITUTIONAL TOTAL STOCK MARKET
 INDEX FUND INSTITUTIONAL SHARES*
 (Inception August 31, 2001)          12.65%                 5.70%                    N/A            0.06%                  0.02%
Average Multi-Cap Core Fund**         11.05                  4.31                     N/A            1.36                   0.56
Dow Jones Wilshire 5000 Index         12.62                  5.62                     N/A             N/A                    N/A

*    Information  about  the  Fund's  Institutional  Plus  Shares  may be  found
     elsewhere in this Statement of Additional information.
**   Derived from data provided by Lipper Inc.



- -    The board  considered  the  Fund's  1-year and  since-inception  investment
     performance,  which is disclosed in the table  above.  The board  concluded
     that the Fund outperformed the average multi-cap core fund and performed at
     or near its benchmark index during those time frames.

- -    The board concluded that, in the aggregate, the nature, extent, and quality
     of services  provided by  Vanguard to the Fund are  appropriate  and should
     continue.

- -    The  board  assessed  the  advisory  expenses  incurred  by  the  Fund  and
     considered  the fair market value of the services  provided in light of the
     expenses  incurred.  The board  concluded  that the expenses  incurred were
     significantly  less  than the  average  advisory  fee paid by others in the
     Fund's Lipper peer group.

- -    Based  upon  its  most  recent  evaluation  of the  investment  staff,  the
     portfolio   management  process,  the  investment   performance,   and  the
     internalized management arrangements, the board of the Fund determined that
     it would be in the best  interests of the Fund's  shareholders  to continue
     its internalized management arrangement.

- -    Finally,  the board considered  whether the Fund should obtain  alternative
     portfolio   management   services  and  concluded   that,   under  all  the
     circumstances  and  based  on its  informed  business  judgment,  the  most
     appropriate   course  of  action  in  the  best  interests  of  the  Fund's
     shareholders  to was continue the investment  management  arrangement  with
     Vanguard.

                                      B-34


VANGUARD INSTITUTIONAL TOTAL BOND MARKET INDEX FUND

The board  considered the following  factors when  determining  whether Vanguard
should continue providing  internalized  investment  management  services to the
Fund:

- -    The nature, extent, and quality of the services provided.

- -    The investment performance of the Fund's assets managed by Vanguard.

- -    The fair market value of the services provided.

- -    A  comparative  analysis of expense  ratios of, and advisory  fees paid by,
     similar funds.

- -    Vanguard's control of the operating expenses of the Fund.

     The specific Fund  performance and advisory fee  information  considered by
the board included the following:


                                                                                                
                                             AVERAGE ANNUAL RETURN (BEFORE TAXES)
                                             ------------------------------------

                                                           5 YEARS               10 YEARS                           ADVISORY FEES
                                                         (or since              (or since                         EXPRESSED AS AN
                                                        inception)             inception)                        ANNUAL EFFECTIVE
                                1 YEAR ENDED                 ENDED                  ENDED                      RATE OF THE FUNDS'
                                  12/31/2004            12/31/2004             12/31/2004    EXPENSE RATIO      AVERAGE NET ASSET
                                  ----------            ----------             ----------    -------------      -----------------
VANGUARD INSTITUTIONAL TOTAL
 BOND MARKET INDEX FUND
(Inception April 26, 2002)             4.36%                 5.88%                    N/A            0.05%                  0.02%
Average Intermediate-Term
 Investment-Grade Fund*                3.85                  5.53                     N/A            1.01                   0.37
Lehman Brothers Aggregate
 Bond Index                            4.34                  6.11                     N/A             N/A                    N/A

*    Derived from data provided by Lipper Inc.



- -    The board  considered  the  Fund's  1-year and  since-inception  investment
     performance,  which is disclosed in the table  above.  The board  concluded
     that the Fund outperformed the average  intermediate-term  investment-grade
     fund and performed at or near its benchmark index during those time frames.

- -    The board concluded that, in the aggregate, the nature, extent, and quality
     of services  provided by  Vanguard to the Fund are  appropriate  and should
     continue.

- -    The  board  assessed  the  advisory  expenses  incurred  by  the  Fund  and
     considered  the fair market value of the services  provided in light of the
     expenses  incurred.  The board  concluded  that the expenses  incurred were
     significantly  less  than the  average  advisory  fee paid by others in the
     Fund's Lipper peer group.

- -    Based  upon  its  most  recent  evaluation  of the  investment  staff,  the
     portfolio   management  process,  the  investment   performance,   and  the
     internalized management arrangements, the board of the Fund determined that
     it would be in the best  interests of the Fund's  shareholders  to continue
     its internalized management arrangement.

- -    Finally,  the board considered  whether the Fund should obtain  alternative
     portfolio   management   services  and  concluded   that,   under  all  the
     circumstances  and  based  on its  informed  business  judgment,  the  most
     appropriate   course  of  action  in  the  best  interests  of  the  Fund's
     shareholders  to was continue the investment  management  arrangement  with
     Vanguard.

     Based upon its most recent  evaluation of each Fund's investment staff, the
portfolio management process, the short- and long-term  performance results, and
the management arrangements for each Fund, the board determined that it would be
in the best  interests of each Fund's  shareholders  to continue the  Management
Agreement.

OTHER ACCOUNTS MANAGED

Donald M. Butler managed the Institutional Index Fund, which, as of December 31,
2004,  held  assets of  $48,483,000,000.  Mr.  Butler  also  managed  four other
registered  investment  companies  with total assets of  $18,324,400,000,  as of
December 31, 2004, and two other pooled investment vehicles with total assets of
$1,357,500,000, as of December 31, 2004.

Michael Perre managed the Institutional Total Stock Market Index Fund, which, as
of December 31, 2004, held assets of $1,240,000,000.  Mr. Perre also managed six
other registered investment companies with total assets of $8,238,000,000, as of
December 31, 2004, and two other pooled investment vehicles with total assets of
$9,277,800,000, as of December 31, 2004.

                                      B-35


Kenneth E.  Volpert  managed the  Institutional  Total Bond  Market  Index Fund,
which, as of December 31, 2004, held assets of $1,170,000,000.  Mr. Volpert also
managed  four  other  registered  investment  companies  with  total  assets  of
$43,080,600,000, as of December 31, 2004.

MATERIAL CONFLICTS OF INTEREST

At Vanguard,  individual  portfolio  managers may manage  multiple  accounts for
multiple clients.  In addition to mutual funds, these other accounts may include
separate  accounts,  collective  trusts,  or offshore  funds.  Vanguard  manages
potential  conflicts  between  funds or with  other  types of  accounts  through
allocation policies and procedures,  internal review processes, and oversight by
directors and independent third parties. Vanguard has developed trade allocation
procedures  and controls to ensure that no one client,  regardless  of type,  is
intentionally  favored  at the  expense  of  another.  Allocation  policies  are
designed to address potential conflicts in situations where two or more funds or
accounts participate in investment decisions involving the same securities.

DESCRIPTION OF COMPENSATION

As of December 31, 2004, a Vanguard portfolio manager's  compensation  generally
consists  of  base  salary,  bonus,  and  payments  under  Vanguard's  long-term
incentive compensation program. In addition, portfolio managers are eligible for
the standard  retirement  benefits and health and welfare benefits  available to
all Vanguard  employees.  Also,  certain portfolio  managers may be eligible for
additional retirement benefits under several supplemental  retirement plans that
Vanguard  adopted in the 1980's to restore  dollar-for-dollar  the  benefits  of
management  employees  that  had been cut  back  solely  as a result  of tax law
changes.  These plans are structured to provide the same retirement  benefits as
the standard retirement benefits.

     In the  case  of  portfolio  managers  responsible  for  managing  multiple
Vanguard funds or accounts,  the method used to determine their  compensation is
the same for all funds and investment accounts.

     A portfolio manager's base salary is determined by the manager's experience
and  performance  in the role,  taking into  account  the  ongoing  compensation
benchmark  analyses  performed by the Vanguard  Human  Resources  Department.  A
portfolio manager's base salary is generally a fixed amount that may change as a
result of an annual  review,  upon  assumption  of new duties,  or when a market
adjustment of the position occurs.

     A portfolio  manager's  bonus is  determined  by a number of  factors.  One
factor is gross,  pre-tax  performance of the fund relative to expectations  for
how the fund should have performed, given its objectives,  policies,  strategies
and limitations,  and the market environment during the measurement period. This
performance  factor  is not  based on the  value of  assets  held in the  fund's
portfolio.  For the Funds,  the  performance  factor  depends on how closely the
portfolio  manager  tracks the fund's  benchmark  index over a one-year  period.
Additional  factors  include  the  portfolio  manager's   contributions  to  the
investment management functions within the sub-asset class, contributions to the
development of other investment  professionals and supporting staff, and overall
contributions to strategic  planning and decisions for the investment group. The
target bonus is expressed as a percentage of base salary.  The actual bonus paid
may be more or less  than the  target  bonus,  based  on how  well  the  manager
satisfies the objectives stated above. The bonus is paid on an annual basis.

     Under the long-term incentive compensation program, all full-time employees
receive a payment from Vanguard's long-term incentive compensation plan based on
their   years  of  service,   job  level,   and,   if   applicable,   management
responsibilities.  Each year,  Vanguard's  independent  directors  determine the
amount of the long-term incentive  compensation award for that year based on the
investment  performance  of the  Vanguard  funds  relative  to  competitors  and
Vanguard's operating efficiencies in providing services to the Vanguard funds.

OWNERSHIP OF SECURITIES

Vanguard employees,  including  portfolio  managers,  allocate their investments
among the various Vanguard funds based on their own individual  investment needs
and goals.  Vanguard  employees  as a group  invest a sizeable  portion of their
personal assets in Vanguard funds. As of December 31, 2004,  Vanguard  employees
collectively invested $1.27 billion in Vanguard funds. John J. Brennan, Chairman
and Chief Executive  Officer of Vanguard and the Vanguard  funds,  and George U.
Sauter, Managing Director and Chief Investment Officer, invest substantially all
of their personal  financial  assets in Vanguard funds. As of December 31, 2004,
the portfolio  managers did not own any shares of the Institutional  Index Funds
they managed.

                                      B-36