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                                        P.O. Box 2600
                                        Valley Forge, PA  19482-2600

                                        610-669-1538
                                        Judy_L_Gaines@vanguard.com

April 3, 2006

Christian Sandoe, Esq.
Division of Investment Management
U.S. Securities and Exchange Commission           via electronic filing
450 Fifth Street,
N.W., Fifth Floor
Washington, D.C. 20549

RE:      Vanguard Institutional Index Fund

Dear Mr. Sandoe:

 The following responds to your comments of March 31, 2006 on the post-effective
amendment of the registration statement of the above-referenced registrant. You
commented on Post-Effective Amendment No. 43 that was filed on February 16,
2006.

Comment 1:        Prospectus - Frequent Trading or Market Timing
- ----------------------------------------------------------------
Comment:          Each Fund's broad policies with respect to frequent trading
                  and market-timing are disclosed under the heading "Frequent
                  Trading or Market-Timing."  However, specific policies
                  applicable to discrete types of investors are disclosed in
                  various places throughout the "Investing with Vanguard"
                  section.  All of each Fund's policies concerning frequent
                  trading and market-timing should be disclosed together under
                  the heading "Frequent Trading and Market-Timing."

Response:         We believe that each Fund's policies against frequent trading
                  and market-timing are properly disclosed in the prospectus
                  pursuant to Item 6(e)(4) of Form N-1A.  Item 6(e)(4) does not
                  require that the specific policies applicable to each type of
                  shareholder be disclosed together in the prospectus.  As such,
                  we believe that it is appropriate to have the general
                  discussion of each Fund's policies against frequent trading
                  and market-timing under the heading "Frequent Trading or
                  Market-Timing" with a reference to the "Investing with
                  Vanguard" section where specific policies applicable to
                  different types of shareholders and transactions are
                  disclosed.

                  We believe that removing the disclosure from the "Investing
                  with Vanguard" section and combining the disclosure into a
                  single "Frequent Trading and Market-Timing" section would make
                  the discussion of transaction policies incomplete in the
                  "Investing with Vanguard" section.  Repeating the specific
                  policies in both the "Investing with Vanguard" section and
                  under the "Frequent Trading and Market-Timing" heading would
                  unnecessarily clutter the prospectus with duplicative
                  disclosure.


April 3, 2006
Page 2

Comment 2:        Prospectus - Back Cover
- -----------------------------------------
Comment:          Clarify that the shareholder reports and the SAI are available
                  at no charge at Vanguard's website.

Response:         We will add the requested clarification.

Comment 3:        Institutional Total Stock Market Index Fund and Total Stock
                  Market Index Fund - Primary Investment Strategy
- -----------------------------------------------------------------
Comment:          Include the market capitalization range of the Fund's target
                  benchmark.

Response:         We have considered the comment but do not plan to add the
                  requested disclosure.  Form N-1A does not specifically
                  require that a market capitalization range be part of a fund's
                  primary investment strategy disclosure.  This particular fund
                  discloses its strategy of tracking its target index that
                  represents the performance of the entire market.  The fund
                  replicates the index by investing most of its assets in the
                  index's largest 1200-1300 stocks, and it samples the remaining
                  stocks.  As a result, like the index, the fund has a market
                  capitalization range that spans the market in its entirety.
                  As such, we do not think the requested disclosure is material
                  in determining whether to invest in the Fund.

Comment 4:        Extended Market Index Fund - Primary Risks
- ------------------------------------------------------------
Comment:          Include disclosure about the risks of small- and mid-cap
                  stocks.

Response:         In the Investment Style Risk section we disclose that the
                  small- and mid-cap stocks held by the Fund could trail the
                  returns of the overall market.  We also includes small- and
                  mid-cap risk disclosure with respect to this Fund in the Item
                  4 disclosure.  We are satisfied that the level of disclosure
                  currently in the prospectus is sufficient.

Comment 5:        Tandy Requirements
- ------------------------------------
Comment:          The SEC is now requiring all registrants to provide at the end
                  of response letters to registration statement comments, the
                  following statements:

                  o The Fund is responsible for the adequacy and accuracy of the
                    disclosure in the filing.
                  o Staff comments or changes in response to staff comments in
                    the filings reviewed by the staff do not foreclose the
                    Commission from taking any action with respect to the
                    filing.
                  o The Fund may not assert staff comments as a defense in any
                    proceeding initiated by the Commission or any person under
                    the federal securities laws of the United States.

Response:         As required by the SEC, we will provide the foregoing
                  acknowledgements.

                                    * * * * *

                  As required by the SEC, the Fund acknowledges that:

                  o The Fund is responsible for the adequacy and accuracy of the
                    disclosure in the filing.
                  o Staff comments or changes in response to staff comments in
                    the filings reviewed by the staff do not foreclose the
                    Commission from taking any action with respect to the
                    filing.
                  o The Fund may not assert staff comments as a defense in any
                    proceeding initiated by the Commission or any person under
                    the federal securities laws of the United States.


April 3, 2006
Page 3

 Please contact me at (610) 669-1538 with any questions or comments regarding
the above responses.  Thank you.

Sincerely,



Judith L. Gaines
Associate Counsel
Securities Regulation, Legal Department