SHIP LOGO VANGUARD(R) P.O. Box 2600 Valley Forge, PA 19482-2600 610-669-1538 Judy_L_Gaines@vanguard.com December 20, 2006 Christian Sandoe, Esq. Division of Investment Management U.S. Securities and Exchange Commission via electronic filing 450 Fifth Street, N.W., Fifth Floor Washington, D.C. 20549 RE: Vanguard Quantitative Funds Dear Mr. Sandoe, The following responds to your comments of December 18, 2006 on the post-effective amendment of the registration statement of the above-referenced registrant. You commented on Post-Effective Amendment No. 31 that was filed on November 1, 2006. Comment 1: Prospectus - Risk/Return Summary - -------------------------------------------------- Comment: Include the Structured Large-Cap Value Fund's policy of investing at least 80% of its assets in large-cap stocks in the risk/return summary. Response: While the Fund does have such a policy, we do not plan to include related disclosure in the risk/return summary. Since that placement is not required by Form N-1A, we prefer to keep the 80% policy in our Item 4 disclosure. Comment 2: Prospectus - Performance/Risk Information - ----------------------------------------------------------- Comment: Clarify that performance information for the Structured Large Cap Value Fund's predecessor trust isn't available for a full calendar year given its January 19, 2006 inception date. Response: As I noted on the phone, the inception date for the predecessor trust is actually December 15, 2005, so we will present a full calendar year of performance in the Fund's Item 2 disclosure. Comment 3: SAI - Investment Limitations - ---------------------------------------------- Comment: In this section of the SAI, please clarify that while the SAI states that compliance with investment limitations is measured at the time securities are purchased, compliance with the borrowing limitation is measured on an ongoing basis. Christian Sandoe, Esq. December 20, 2006 Page 2 Response: We will make the requested modification. Comment 4: Prospectus and SAI - Throughout the N-1A - ---------------------------------------------------------- Comment: Include updated financial information for the registrant's existing series as necessary. Response: We will include updated financial information as necessary. Comment 5: Tandy Requirements - ------------------------------------ As required by the SEC, the Fund acknowledges that: o The Fund is responsible for the adequacy and accuracy of the disclosure in the filing. o Staff comments or changes in response to staff comments in the filings reviewed by the staff do not foreclose the Commission from taking any action with respect to the filing. o The Fund may not assert staff comments as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States. Please contact me at (610) 669-1538 with any questions or comments regarding the above responses. Thank you. Sincerely, Judith L. Gaines Associate Counsel Securities Regulation, Legal Department