AMENDMENT NO. 8 TO EMPLOYMENT AGREEMENT

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     THIS AMENDMENT NO. 8 TO EMPLOYMENT  AGREEMENT (the "Amendment") is made and
entered into at Santa Barbara,  California, on the date hereinafter set forth by
and between Gary S. Kledzik,  Ph.D.  (hereinafter referred to as the "Employee")
and MIRAVANT MEDICAL TECHNOLOGIES,  a Delaware Corporation (hereinafter referred
to as the "Employer").

WHEREAS:

     A. The Employer and the  Employee  are parties to an  Employment  Agreement
effective as of December 31, 1989,  and  Amendments No. 1 through 7 thereto (the
"Employment Agreement").

     B. The parties  hereto wish to amend the  Employment  Agreement  in certain
respects.

     NOW,   THEREFORE,   in   consideration   of  the  premises,   promises  and
representations hereinafter contained, it is agreed as follows:

     1. Effective JANUARY 1, 2000, the section entitled EMPLOYEE COMPENSATION on
Exhibit A to the Employment Agreement is hereby amended to read as follows:

               EMPLOYEE COMPENSATION

               THREE   HUNDRED  FIFTY  SEVEN   THOUSAND  FIVE  HUNDRED   DOLLARS
               ($357,500) per annum.

     2. In all other  respects,  the  Employment  Agreement is hereby  ratified,
confirmed and approved in its entirety.




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         IN WITNESS WHEREOF,  the parties hereto have executed this Amendment on
this 25th day of January, 2000.

                                                EMPLOYER:
                                                MIRAVANT MEDICAL TECHNOLOGIES
                                                a Delaware Corporation

                                                By:   /s/ David E. Mai
                                                ----------------------
                                                          David E. Mai
                                                          President

                                                EMPLOYEE:
                                                /s/ Gary S. Kledzik, Ph.D.
                                                --------------------------
                                                    Gary S. Kledzik, Ph.D.