EXHIBIT 10.40

                             LEASE RENEWAL AMENDMENT
                                   1045179-001

         THIS LEASE RENEWAL AMENDMENT dated as of July 1, 2003 ("Amendment")
amends Schedule No. SG02 ("Schedule") to the Master Lease Agreement dated as of
September 13, 1995 ("Agreement"), such Schedule and Agreement, as the same may
have been heretofore amended or otherwise modified, are hereinafter collectively
referred to as the ("Lease") between General Electric Capital Corporation
Successor In Interest to Comdisco, Inc. as of February 25, 2002 ("Lessor") and
La Jolla Pharmaceutical Company ("Lessee"). Capitalized terms not defined herein
shall have the meanings assigned to them in the Lease.

                               W I T N E S S E T H

         WHEREAS, the term of the Lease is scheduled to expire on June 30, 2003
("Primary Term Expiration Date"); and

         WHEREAS, Lessee desires to renew the Lease pursuant to the terms set
forth herein; and

         WHEREAS, Lessor is willing to consent to such renewal pursuant to the
terms set forth herein;

         NOW, THEREFORE, in consideration of the above premises and the mutual
promises contained herein, as well as other good and valuable consideration, the
receipt and sufficiency of which is hereby acknowledged, the parties hereto,
intending to be legally bound, agree as follows:

     1.  Commencing on July 1, 2003, the Lease shall be renewed for an
         additional period of Twenty Four (24) months ("Renewed Term") on and
         subject to the same terms and conditions as set forth in the Lease,
         except as otherwise expressly provided herein:

         (a)      During the Renewed Term, Lessee hereby agrees to pay to Lessor
                  rent in the total principal sum One Hundred Eleven Thousand
                  and 00/100 Dollars ($111,000.00), with interest thereon, from
                  the date upon which the Renewed Term commences through and
                  including the last day of the Renewed Term, at a fixed
                  interest rate of Seven percent (7.0%), to be paid in Eight (8)
                  consecutive Quarterly installments of principal and interest
                  of Fourteen Thousand Seven Hundred Thirty Seven and 00/100
                  Dollars ($14,737.00) (each a "Periodic Installment") and a
                  final installment equal to the GPO Amount (as that term is
                  described below). The Periodic Installments have been
                  calculated on the basis of a 360 day year of twelve thirty-day
                  months. Each Periodic Installment may, at the option of the
                  Lessor, be calculated and applied on the assumption that such
                  installment would be made on its due date. The first Periodic
                  Installment shall be due and payable on July 1, 2003 and the
                  following Periodic Installments shall be payable on the same
                  day of each month thereafter throughout the Renewal Term.

         (b)      During the Renewed Term, the Stipulated Loss Value and
                  Termination Value of the Equipment as of the applicable
                  calculation date shall be equal to (i) the sum of (A) all then
                  remaining Periodic Installment payments (which would have come
                  due over the balance of the Renewed Term without any
                  termination thereof), and (B) the GPO Amount (set forth
                  hereinbelow), (ii) discounted to its then present value using
                  a discount rate equal to the one year U.S. Treasury Constant
                  Maturity rate in effect as of the date on which the Lease
                  either terminates or the Casualty occurs, as published in the
                  Federal Reserve Statistical Release H.15 (519). Furthermore,
                  in connection with any default or other termination of the
                  Lease prior to the scheduled expiration of the Renewed Term,
                  any surplus net proceeds received by Lessor from the sale,
                  re-lease or other disposition of the Equipment after
                  satisfaction of all amounts payable by Lessee under the Lease
                  shall be remitted to Lessee (except to the extent as may be
                  otherwise required by applicable law).

         (c)      Upon expiration of the Renewed Term, Lessee shall purchase for
                  cash consideration all (but not less than all) of the
                  Equipment for an amount equal to One and 00/100 Dollar ($1.00)
                  (the "GPO Amount"), plus all applicable sales, use and other
                  taxes thereon, ON AN "AS IS, WHERE IS" BASIS WITHOUT RECOURSE
                  TO, OR WARRANTY BY, LESSOR OF ANY KIND, NATURE OR DESCRIPTION
                  WHATSOEVER. All other purchase options or renewal options are
                  hereby deleted in their entirety.



         (d)      In order to secure payment and performance of Lessee's
                  obligations hereunder, Lessee hereby grants Lessor a security
                  interest in (i) the Equipment and in all goods that are or may
                  hereafter become accessions thereto, and (ii) all proceeds of
                  such property, including but not limited to insurance
                  proceeds.

         (e)      Any provisions of the Lease relating to Early Termination,
                  Purchase Option or Terminal Rent Adjustment Clause shall be
                  deleted in their entirety.

     2.  Lessee hereby represents and warrants that all of the representations
         and warranties included in the Lease (except as set forth in Article XV
         (b) of the Lease) are true and correct as of the date first above
         written.

     3.  Except as expressly modified herein, all terms and provisions of the
         Lease shall remain in full force and effect.

         IN WITNESS WHEREOF, the parties hereto have caused their duly
         authorized representatives to execute and deliver this Amendment as of
         the date first above written.

LESSOR:                         LESSEE:
GENERAL ELECTRIC CAPITAL        LA JOLLA PHARMACEUTICAL COMPANY
CORPORATION SUCCESSOR IN
INTEREST TO COMDISCO INC.
AS OF FEBRUARY 25, 2002

By: /s/ Michael J. Fernand      By: /s/ Gail A. Sloan
   -------------------------       --------------------------------------------

Title: Collateral Specialist    Title: Senior Director of Finance and Controller