Exhibit 99.1

      AMENDMENT No. 4 (this "Amendment"), dated as of June 30, 2005, to the
Share Exchange Agreement dated as of March 15, 2005 and as amended by Amendment
No. 1 dated as of March 15, 2005, Amendment No. 2 dated as of April 21, 2005 and
Amendment No. 3 dated as of May 31, 2005 (the "Agreement"), by and among
EPIMMUNE INC., a Delaware corporation (the "Issuer"), and the shareholders of
IDM S.A., a societe anonyme organized under the laws of France (the "Company"),
listed on Exhibit A attached thereto (the "Principal Company Shareholders").
Capitalized terms used but not defined herein shall have the meanings assigned
to such terms in the Agreement.

                                    RECITALS:

      A. The Issuer and the Principal Company Shareholders have entered into the
Agreement;

      B. The Principal Company Shareholders have appointed Helene Ploix, as
Shareholder Representative, and have empowered her to execute amendments to the
Agreement which may be necessary or desirable to complete the Agreement; and

      C. The Issuer and the Shareholder Representative, on behalf of the
Principal Company Shareholders, have agreed to enter into this Amendment No. 4
to the Agreement.

      NOW, THEREFORE, in consideration of the foregoing and the rights and
obligations contained herein, and intending to be legally bound hereby, the
Issuer and the Shareholder Representative hereby agree as follows:

            Section 1. Termination. Section 8.01(b) of the Agreement shall be
deleted and replaced in its entirety by the following paragraph:

            (b) by either the Issuer or the Shareholder Representative on behalf
      of the Principal Company Shareholders if the Closing shall not have
      occurred on or before June 30, 2005 (the "End Date"); provided, however,
      that the End Date shall be August 26, 2005 in the event that the Issuer or
      its counsel shall receive a comment letter on the Proxy Statement from the
      SEC; and provided further that the right to terminate this Agreement under
      this Section 8.01(b) shall not be available to any party whose failure to
      fulfill any obligation under this Agreement has been the cause of, or
      resulted in, the failure of the Closing to occur on or before such date;

            Section 2. Entire Agreement. The Agreement, as amended by this
Amendment constitutes the entire agreement of the parties with respect to the
subject matter hereof and supersedes all prior agreements and undertakings, both
written and oral, between the parties and the Principal Company Shareholders
with respect to the subject matter thereof and hereof. Except as amended by this
Amendment, the Agreement shall continue in full force and effect in accordance
with its terms.

            Section 3. Severability. If any term or other provision of this
Amendment is invalid, illegal or incapable of being enforced by any rule of Law,
or public policy, all other conditions and provisions of this Amendment shall
nevertheless remain in full force and effect so long as the economic or legal
substance of the Transactions contemplated by this Amendment is not affected in
any manner materially adverse to any party. Upon such determination that any
term or other provision is invalid, illegal or incapable of being enforced, the
parties hereto shall negotiate in good faith to modify this Amendment so as to
effect the original intent of the parties as closely as possible in a mutually
acceptable manner in order that the Transactions be consummated as originally
contemplated by the Agreement as amended by this Amendment to the fullest extent
possible.

            Section 4. Counterparts. This Amendment may be executed and
delivered (including by facsimile transmission) in one or more counterparts, and
by the different parties hereto in separate counterparts, each of which when
executed shall be deemed to be an original but all of which taken together shall
constitute one and the same agreement.

            Section 5. Governing Law. (a) This Amendment shall be governed by,
and construed in accordance with, the laws of the State of Delaware applicable
to contracts executed in and to be performed in that jurisdiction, excluding (to
the greatest extent a Delaware court would permit) any rule of law that would
cause the application of the laws of any jurisdiction other than the State of
Delaware.

      (b) The parties irrevocably agree that any dispute, controversy or claim
arising out of or relating to this Amendment or the transactions contemplated
thereby, or the breach, termination or invalidity thereof, shall be settled by
arbitration in accordance with the Rules of Conciliation and Arbitration of the
International Chamber of Commerce as at present in force. The place of
arbitration shall be Orange County, California and the number of arbitrators
shall be three. Each of (i) the Shareholder Representative, on behalf of the
Principal Company Shareholders, on the one hand, and (ii) the Issuer, on the
other hand, shall designate one arbitrator and the two so designated arbitrators
shall jointly designate the third arbitrator. If such designation is not made
within fifteen (15) days of the designation of the second party designated
arbitrator, the Secretary General of the International Court of Arbitration of
the International Chamber of Commerce shall designate the third arbitrator. The
language of the arbitral proceedings shall be English, but all submissions and
written evidence may be in French or English.


                                       2

      IN WITNESS WHEREOF, the Issuer and the Principal Company Shareholders,
represented by the Shareholder Representative have executed, or have caused to
be executed by their respective officers thereunto duly authorized, this
Amendment as of the date first written above.

                                  EPIMMUNE INC.

                                  By: /s/ ROBERT DE VAERE
                                      -----------------------------------------
                                      Name: Robert De Vaere
                                      Title: Vice President, Finance and
                                      Administration, Chief Financial Officer
                                      and Secretary


                                  PRINCIPAL COMPANY SHAREHOLDERS,
                                  Represented by the Shareholder Representative

                                  By: /s/ Helene Ploix
                                      -----------------------------------------
                                      Name: Helene Ploix
                                      Title: Shareholder Representative