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                                                                  EXHIBIT 10.66




Date:            November 4, 1996

To:              David B. Thomas

From:            Ed Erickson

Subject:         Confidential Early Retirement And Separation Agreement

Dear David:

Consistent with our discussions concerning your early retirement and separation
from DepoTech Corporation (the "Company"), this letter will constitute the
Confidential Early Retirement And Separation Agreement (the "Agreement")
setting forth the terms of your employment from and after the date of this
agreement, and separation of employment from the Company.  By signing this
Agreement, you will be agreeing to these terms.  It is important that you
understand clearly both what your benefits and obligations are and what is
expected of you by the Company.

1.  Transition Period:  Commencing on the date of this Agreement, and
    continuing through the date of the first commercial sale of DepoCyt in the
    United States, (hereinafter referred to as the "Transition Period"), you
    and the Company are in agreement on the future discontinuance of your
    employment with the Company.  Subject to the terms and conditions of this
    Agreement, inclusive but not limited to, Section 6, during the Transition
    Period, you shall remain a regular full-time employee and officer of the
    Company.  The parties may mutually agree in writing to extend the
    Transition Period, but neither is under any obligation to do so
    (hereinafter referred to as the "extended Transition Period").

    On the date of  the Company's first commercial sale of DepoCyt in the
    United States, provided you have continued employment with the Company
    through the date of such first commercial sale,  you and the Company will
    execute a Consulting Agreement as specified in Attachment A ("Consulting
    Agreement").

2.  Duties:  During the Transition Period you will be responsible for
    performing those assignments you currently perform and duties substantially
    similar to such assignments,  plus any other project assignments agreed
    with the Chief Executive Officer (CEO) of the Company.  In addition, you
    will make yourself available to the Company for the purpose of
    transitioning your work to other employees and to answer any questions
    regarding matters assigned to you before the effective date of Separation,
    as defined below.  During the Transition Period, you will devote your full
    energies, efforts and abilities to achieving FDA approval of DepoCyt,
    toward  making significant progress on and achieving milestones in other
    key projects and to your employment with the Company.

3.  Position Title and Salary:  Effective as of August 27, 1996, your title
    will be Senior Vice President, Quality Assurance and Regulatory Affairs.
    In addition, the Company agrees to retroactively increase your base salary
    to $14,167.00 per month.  The "new base salary" will be subject to the
    normal review of, and changes to, salaries of all SMC members, effective
    January 1, 1997.  All salary payments will be less customary and applicable
    deductions for taxes and health and other benefits.  All salary payments
    during the Transition Period shall be made on or about the time of the
    Company's normal bi-monthly pay cycle.
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4.  Benefits:  During the Transition Period, the Company will continue your
    current health benefits, Long Term Disability, Life Insurance, and
    participation in the Company's 401(k)  and ESPP plans.

5.  Expiration of Transition Period/Early Retirement And Separation of
    Employment:  Your early retirement and separation of employment with the
    Company will occur on the last day of the Transition Period, unless your
    separation of employment occurs sooner pursuant to Section 6, or is
    extended pursuant to Section 1, (the "Transition Period").  As part of
    this, the Company agrees to provide you with the following additional
    compensation and benefits package:

         a.  Cash Bonus:  Upon issuance by the FDA, of an  "Approvable Letter"
         for DepoCyt, the Company will pay you a cash bonus of forty thousand
         dollars ($40,000), providing such issuance occurs during the
         Transition Period.

         b.  Accelerated  Stock Option Grant Vesting:  If you remain employed
         with the Company until the FDA issues an "Provisional Approval Letter"
         for DepoCyt, the Company agrees to accelerate the vesting of Stock
         Options remaining unvested as of the date of such issuance, and
         awarded in these quantities and on the following dates:

                          ISO GRANT        40,000 SHARES    GRANTED 07-01-93
                          ISO GRANT        10,000 SHARES    GRANTED 03-23-94
                          ISO GRANT           200 SHARES    GRANTED 09-28-95
                          ISO GRANT         6,750 SHARES    GRANTED 01-16-96

         In addition, the Company confirms that the vesting of Stock Options
         remaining will accelerate in their entirety by these terms in the
         event of (1) a change of control of the Company and (2) disability
         longer than three (3) months or death.

         c.  Management Incentive Bonus:  During the Transition Period, you
         will be eligible for 1996 Management Incentive Bonus consideration to
         be paid out in 1997, based on the combination of your performance and
         that of the Company during the 1996 fiscal year.  The Management
         Incentive Bonus target for 1996 is twenty percent (20%) of base
         salary, however it can be as little as 0% or as high as 33% of base
         salary depending on overall company and individual performance.

         d.  Extended Benefits:  You and your eligible dependents will be
         entitled to continue your medical coverage, pursuant to COBRA, for 18
         months following the effective date of Separation at your own expense.
         It is understood that the Company reserves the right to change health
         plans at any time.  All other employee benefits, including Long Term
         Disability, Life Insurance, 401(k) and ESPP plan participation will
         expire on the effective date of the Separation.

         e.  FTO Balance:  The Company further agrees to pay you all earned but
unused FTO pay as of the date of Separation.

In consideration for the above package, you will be required to sign a release
agreement with the Company releasing it from any and all litigation or claims
which is set for at Section 11 of this Agreement.

6.  Termination:  Either party may terminate your employment during the
    Transition Period or any extended Transition Period, under the following
    terms and conditions:





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         a.  You may terminate your employment with the Company during the
             Transition Period, for any reason, upon thirty (30) days written
             notice to the Company.  Upon such a termination, your employment
             will be terminated and all compensation and benefits pursuant to
             Sections 3 and 4 will end.  If you resign, you will not be
             entitled to any compensation or benefits described in Section 5
             subsections (a-c).

         b.  The Company reserves the right to terminate your employment during
             the Transition Period or any extended Transition Period "for
             cause".  "For cause" termination includes: (a) a material breach
             of the terms of this Agreement; (b) refusal or failure to perform
             the duties assigned to you pursuant to this Agreement, following
             notice from the company of such refusal or failure and a
             reasonable opportunity to cure; (c ) major infractions of the
             Company's standards of conduct as set forth in Company policies,
             following notice from the Company of such infractions and a
             reasonable opportunity to cure; (d) your acceptance of employment
             or consultancy with another entity or person such that you can no
             longer devote your full energies to employment with the Company;
             or (e) disability longer than three (3) months or death.  Upon
             termination "for cause', all compensation and benefits pursuant to
             Sections 3 and 4 will end.  In addition, you will not be entitled
             to any compensation or benefits described in Section 5 subsections
             (a -c), except in the case of (e) disability longer than three (3)
             months or death, you will be entitled to the benefits described in
             Section 5 subsection (b) Accelerated Stock Option Grant Vesting.

7.  Confidentiality:  You agree that as a specific condition to the performance
    of this Agreement by the Company, you will not disclose for any purpose,
    the fact of this Agreement, the terms of this Agreement or the negotiations
    leading up to this Agreement to any person, except to your immediate family
    or as may be necessary for purposes of securing legal or tax advice or as
    otherwise may be required by law.

8.  Inventions/Confidential Information:  You agree that the Employee
    Proprietary Information and Inventions Agreement signed by you shall remain
    in full force and effect following the effective date of Separation.  In
    addition, we wish to remind you of your obligations regarding the
    confidentiality of the Company's commercial and technical proprietary
    information.  You understand and agree that all confidential and
    proprietary information that you may have received during your employment
    or may receive during the Transition Period with the Company shall remain
    strictly confidential and held by you in confidence.

9.  Goodwill and Compliance with Company Policies:  You agree that you shall
    not make, encourage or otherwise cause to be made any negative or
    disparaging comments or statements (whether verbal or written) about the
    Company or take any action which will place the Company in a bad light or
    false light.  You further agree that during the Transition Period you will
    abide by and comply with the policies and procedures of the Company.

10. No Admission:  This Agreement shall not be construed or used as an
    admission of liability or wrongdoing by either you or the Company.

11. Release:  In return for the above promises and payments to you, you agree
    that you will not file or cause to be filed any charges, lawsuits, or other
    actions of any kind against the Company, its agents, successors, officers,
    directors, or employees, arising out of, or relating in any way to, your
    employment and/or separation of your employment with the Company including,
    but not limited to actions alleging breach of contract, tort, legal actions
    under Title VII of the Civil Rights Act of 1964, as amended, Section 1981
    of the Civil rights Act of 1866, the Veterans Readjustment Assistance Act,





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    the Rehabilitation Act of 1973, the Americans with Disabilities Act, or any
    other State, Federal or local law concerning age, race, religion, national
    origin, handicap, or any other form of discrimination, or any other law or
    regulation.

    You understand and agree that all rights under Section 1542 of the Civil
    Code of the State of California are hereby expressly waived.  It is
    understood that Section 1542 of the California Civil Code provides as
    follows:

             "A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR
             DOES NOT KNOW OR SUSPECT TO EXIST IN HIS FAVOR AT THE TIME OF
             EXECUTING THE RELEASE, WHICH IF KNOWN BY HIM MUST HAVE MATERIALLY
             AFFECTED HIS SETTLEMENT WITH THE DEBTOR."

12. Entire Understanding:  This Agreement, including the attachments hereto,
    contains the entire understanding between you and the Company relating to
    your continued employment, Early Retirement And Separation package,
    superseding all prior understandings and agreements between the parties, if
    any.

13. Arbitration:  In the event of a dispute over the performance,
    interpretation or validity of this Agreement, the parties agree to submit
    any and all disputes relating to this Agreement to binding arbitration
    before JAMS/Endispute, Southern California.  Any arbitration award shall be
    final and binding on the parties and may be entered in any court having
    jurisdiction.

14. Applicable Law:  This Agreement will be governed by laws of the State of
    California, without regard to the principles of conflicts of laws.

David, you are entitled by law to review this Agreement for a period of 21
days.  The Company encourages you to use this opportunity to review the
Agreement with an attorney.  Should you decide not to use the full 21 days,
then you knowingly and voluntarily waive any claims that you were not in fact
given 21 days to consult an attorney and/or review the Agreement.

In addition, for a period of seven (7) days following your execution of this
Agreement, you may revoke this Agreement, and the Agreement shall not become
effective or enforceable until the revocation period has expired.  Any
revocation within the seven days must be in writing, addressed to Thomas
Swedberg SPHR at DepoTech Corporation's address (10450 Science Center Drive,
San Diego, CA 92121).  If you revoke this Agreement, it shall not be effective
or enforceable and you will not receive the benefits described in Sections 3, 4
and 5 (a-c).

If you agree with the foregoing package and release, please sign below.  You
agree that you have read and understand this Agreement, and that you have
signed it freely and voluntarily.

Sincerely,


/s/ Edward L. Erickson
Edward L. Erickson
President and CEO




Agreed:
                 /s/ David B. Thomas                  November 5, 1996
         ________________________________________  _______________________
                     David B. Thomas                         Date





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                                   EXHIBIT A

                              CONSULTING AGREEMENT



This consulting agreement is made and entered into this (  ) day of (Month),
1997, by and between DepoTech Corporation, a California corporation, having its
principal place of business at 10450 Science Center Drive, San Diego,
California 92121 ("Company") and David B. Thomas, an individual, residing at
325 Punta Baja Drive, Solana Beach, California  92075-1720 (Consultant).

WHEREAS, Company desires to retain Consultant to perform certain services, and
Consultant is agreeable to doing so;

NOW, THEREFORE,  in consideration of the foregoing recitals and of the mutual
covenants and conditions set forth below, the parties agree as follows:

1.  Services Fees.  Consultant hereby is retained as an independent contractor
to provide consulting services described in Exhibit A1 hereto.  Consultant
shall receive consulting fees for such services and reimbursement for
reasonable business travel and expenses as set forth in Exhibit A1 hereto.
Such consulting services shall be performed as requested from time to time by
the Company's executive officers.

2.  Term.  The initial term of this Agreement shall commence on the date hereof
and continue for a period of one (1) year ("Consulting Period").  Consultant's
services shall be rendered as requested by Company and in a manner satisfactory
to Company.  Consultant and Company agree that during the term of this
Agreement, Consultant will provide approximately One Hundred Sixty Two (162)
days of consulting services.  This Agreement shall be cancelable by either
party upon the giving of ninety (90) days prior written notice.

3.  Manner of Performance.  Consultant represents that Consultant has the
requisite expertise, ability and legal right to render the consulting services,
and will perform the consulting services in an efficient manner and in
accordance with the terms of this Agreement.  Consultant will abide by all
laws, rules and regulations that apply to the performance of the consulting
services and when on Company premises, will comply with Company's policies with
respect to conduct of visitors.

4.  Confidentiality.

(a) Consultant recognizes that in performing services under this Agreement he
    will have contact with information of substantial value to Company, which
    is not generally known and which gives Company an advantage over its
    competitors who do not know or use it, including but not limited to
    improvements to the DepoFoam Technology, techniques, drawings, processes,
    inventions, developments, sales and customer information, and business and
    financial information, relating to the business, products, practices or
    techniques of Company and of any other corporation or entity that may be a
    party to a particular transaction with the Company (hereinafter referred to
    as "Confidential Information").  Confidential Information shall also
    include information belonging to a third party which Company is obligated
    to keep confidential from others.  Consultant agrees, at all times, to
    regard and preserve as confidential such Confidential Information, and to
    refrain from publishing or disclosing any part of such Confidential
    Information and from using it except on behalf of Company, without prior
    written consent of Company.  Consultant further agrees, at all times, to
    refrain from any other acts or omissions that would reduce the value of
    such Confidential Information to Company.





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(b) Upon termination of this Agreement, Consultant agrees to promptly surrender
    to Company all documents or items which are the property of Company or
    which contain or comprise such Confidential Information.

(c) Consultant's duties of confidence to Company and other duties pursuant to
    this Agreement, shall survive the termination of this Agreement for any
    reason.

5.  Reports.  Any reports, specifications or other materials prepared by
Consultant for the purpose of or pursuant to this Agreement shall be the
property of Company exlclusively and shall be maintained in confidence by
Consultant.

6.  Inventions.

(a) Consultant agrees to promptly and fully disclose in writing to Company any
    invention, discovery, development, improvement, method or product, know-how
    and data, whether or not patentable, which are made, conceived or reduced to
    practice by Consultant during the term of this Agreement that result from
    any work performed by Consultant for Company pursuant to this Agreement.

(b) Consultant agrees that such inventions shall be the sole property of
    Company and agrees to assign and hereby assigns to Company such inventions.

7.  Independent Contractor.  Consultant's relationship with the Company is and
shall be that of an independent contractor, and neither party is authorized to
nor shall act as the agent of the other.  Consultant agrees that he will be
solely responsible for the payment of all taxes relating to the compensation
paid pursuant to this Agreement.

8.  Notices.  Unless otherwise provided, any notice required or permitted under
this agreement shall be given in writing and shall be deemed effectively given
upon personal delivery to the party to be notified or upon deposit with the
United States Post Office, by registered or certified mail, postage prepaid and
addressed to the party to be notified at the address for such party set forth
in the introductory paragraph above, or at such other address as such party may
designate by ten (10) days' advance written notice to the other parties.

9.  Remedies.  Consultant acknowledges that any disclosure or unauthorized use
of Confidential Information will constitute a material breach of this Agreement
and cause substantial harm to Company for which damages would not be a fully
adequate remedy, and, therefore, in the event of any such breach, in addition,
to other available remedies, Company shall have the right to obtain injuctive
relief.

10.  Attorneys' Fees. If any action at law or in equity is necessary to enforce
or interpret the terms of this Agreement, the prevailing party shall be
entitled to reasonable attorneys' fees, costs and necessary disbursements in
addition to other relief to which such party may be entitled.

11.  Successors and Assigns.  This Agreement shall be binding upon Consultant,
and inure to the benefit of, the parties hereto and their respective heirs,
successors, assigns, and personal representatives; provided, however, that it
shall not be assignable by Consultant.

12.  Amendment and Modification.  No amendment, modification or supplement of
this Agreement shall be binding unless executed in writing and signed by all of
the parties hereto.





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13.  Entire Agreement: Governing Law.  This Agreement contains the entire
understanding of the parties with respect to the matters contained herein.
This Agreement shall supersede any and all previous and existing Consulting
Agreements between Company and Consultant.  This Agreement shall be governed by
and construed in accordance with the laws of the State of California, without
regard to principles of conflicts of law.





IN WITNESS WHEREOF,  the parties have executed this Agreement effective as of
the date first above written.



                                  DepoTech Corporation, a California corporation



                                  By: ______________________________________



                                  CONSULTANT



                                  By:_______________________________________
                                                        (Name)





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                                   EXHIBIT A1



Scope of Services of Consutant.

The scope of consulting work contemplated by this Agreement shall be as
follows:

Provide consultation on an as requested basis concerning Quality Assurance,
Quality Control, Regulatory Affairs, Clinical Data Management and Clinical
Studies work, issues, plans and actions.  Provide information and assistance to
the heads of these functions to improve the overall content, quality, cost or
timeliness of the work being done within their organizations.

Provide consultation on an as requested basis to the heads of Quality
Assurance, Quality Control, Regulatory Affairs, Clinical Data Management and
Clinical Studies to increase their knowledge, skills and competencies in their
respective area(s) of responsibility.

Provide consultation to the President and  SMC on an as requested basis for
long and short term strategic and operational planning, marketing and business
development planning and other general planning.

Participate on an as requested basis in meetings with vendors, customers,
regulatory agencies and other organizations to provide historical and practical
knowledge and perspective for information sharing and decision making.

Consulting Fees.

Consultant shall be compensated as follows:

Consultant shall receive a retainer of Thirteen Thousand Five Hundred Dollars
($13,500.00) per month.  Consultant's services are expected to be required for
no less than one hundred sixty two (162) days during the Consulting Period.
Consultant will submit to the Company a record of all days worked during each
month, plus an invoice for all reasonable business related travel and expenses.

Company will accelerate vesting of Stock Options remaining unvested and awarded
in the quantity of 10,000 Shares, Granted 03-23-94, with a vesting start date
of July 1, 1997.  The remaining unvested shares will vest equally on a monthly
basis during the Consulting Period.

Consultant will be reimbursed for all reasonable business related travel and
entertainment expenses according to Company policy.





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